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Subretinale Blutungen können in Abhängigkeit von ihrer Lage und Ausmaß zu einer erheblichen Beeinträchtigung der Sehfunktion führen. Ursachen sind neben der altersbedingten Makuladegeneration die diabetische Retinopathie, Gefäßanomalien und -verschlüsse, Trauma,[zum vollständigen Text gelangen Sie über die oben angegebene URL], 68. Tagung der Vereinigung Norddeutscher Augenärzte (VNDA)

BACKGROUND: Combination therapy of photodynamic therapy (PDT) with intravitreal triamcinolone (IVTA) for choroidal neovascularisation (CNV) in age-related macular degeneration is thought to improve the prognosis. It is therefore widely used, although results are mostly based upon non-randomised and retrospective studies. Here we present the 6-month results of our prospective, randomised, multicentre ITAP trial (Intravitreal Triamcinolone and PDT) for the evaluation of the combination therapy as compared to PDT alone. PATIENTS: This prospective, randomised, multicentre phase III trial was performed for the evaluation of the efficacy and safety of combination therapy (PDT and IVTA) as compared to PDT alone. Three randomised therapy groups (A: PDT alone, B: IVTA on the same day 1 hour after PDT C: IVTA 1 week before PDT) were monitored over 1 year. The patients included had wet AMD with predominantly classic CNV, minimal classic CNV smaller than 4 papillary diameters or occult CNV with recent disease progression. Re-treatment was performed when persistent leakage of the CNV was visible at follow-up. Primary outcome criteria were the comparison between combination therapy and PDT monotherapy concerning visual acuity, and, second, the comparison between the two groups of combination therapy. RESULTS: 92 patients were included in the study. Before treatment, mean best corrected ETDRS letter score was 52, 53 and 51 in groups A, B and C, respectively. At the 6 months follow-up, mean best corrected letter score was 40, 47 and 47, respectively, with only group A loosing more than 10 letters. This change, however, was not statistically significant between the groups. Mean retinal thickness as measured with optical coherence tomography decreased in all groups, and reached statistical significance in both combination groups. Re-treatment rates did not differ significantly between the three groups at 6 months follow-up, nor was there a significant cataract progression requiring operation. CONCLUSION: At 6 months there was no significant difference between mono- and combination therapy groups concerning visual acuity.

Ocriplasmin ist ein seit März 2013 zugelassenes Medikament zur Behandlung des vitreomakulären Traktionssyndroms (VMTS) auch im Zusammenhang mit einem Makulaloch (MF), 28. Jahrestagung der Retinologischen Gesellschaft

Hintergrund: Die Verflüssigung durch ein fibrinolytisches Medikament und die Verlagerung in die Peripherie durch eine Gas-Endotamponade mit nachfolgender Lagerung ist die bevorzugte Therapie für mittelgroße akute zentrale subretinale Blutungen im Rahmen einer neovaskulären AMD. Die[for full text, please go to the a.m. URL], 65. Tagung der Vereinigung Norddeutscher Augenärzte

Ocriplasmin ist ein seit 2013 zugelassenes Medikament zur minimalinvasiven Behandlung des vitreomakulären Traktionssyndroms (VMTS) mit oder ohne kleiner Makulaforamina. Diese Studie untersucht die anatomischen und funktionellen Ergebnisse nach einer einmaligen intravitrealen Applikation von Jetrea®.[for full text, please go to the a.m. URL], 65. Tagung der Vereinigung Norddeutscher Augenärzte

Background: Spontaneous enophthalmos without recent trauma is a rare condition. Its origin is difficult to evaluate. Method: Specific properties of this symptom complex are presented based on a literature review and on case reports. Possible connections between enophthalmos and paranasal sinus diseases as well as differential diagnoses are analysed. Patients: 1. 31 year old female patient with right spontaneous enophthalmos and no history of trauma. CT-imaging disclosed tissue formation in the maxillary sinus, partially destroyed medial orbital wall and floor, descended orbital contents following Caldwell-Luc procedure several years previously. After endonasal surgery of ethmoidal and maxillary sinus with removal of a large cyst good functional and cosmetical result. 2.25 year old male patient complaining of pain in the periorbital region, presenting with left enophthalmos and superonasal deviation of the eyeball. MRI and CT revealed a tumor in the orbital floor region with total destruction of the roof of the maxillary sinus. Removal of the tumor by a combined lateral rhinotomy and subciliary approach. Diagnosis: Leiomyoma. Orbital reconstruction with PDS-sheet. Postoperatively, improved globe position and motility. No recurrence during three year follow-up. Conclusion: When evaluating the causes of enophthalmos, chronic diseases of the paranasal sinuses or their walls must be considered. Surgical therapy is promising.

Hintergrund: Nach Exzision maligner Unterlidtumoren resultieren häufig ausgedehnte Defekte. Für größere Defekte (>1/3 der Unterlid-Breite) stehen mehrere Techniken zur Auswahl. Ziel der Studie: Retrospektive interventionelle Fallserie zur Untersuchung der Komplikationsrate[for full text, please go to the a.m. URL], 173. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte

Einleitung: Frakturen oder Kontusionen im Canalis opticus können zu mannigfaltigen Schäden führen. Neben einer Abscherung des Nerven sind dies Oedeme oder Hämatome. Folge ist ein Visusverlust und/oder eine Gesichtsfeldeinschränkung. Methoden: 30 Patienten, bei denen[for full text, please go to the a.m. URL], 80. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie