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Multi-year vision about solutions to provide user-oriented, i.e. non-physics, storage for the CERN community, in particular for use-cases on Linux PCs, lxplus, and lxbatch.

In the framework of ERASMUS+ program Key Action “Cooperation for innovation and the exchange of good practices” with an Action Type “Strategic Partnerships for vocational education and training”, our project TRack Your ATmosphere (TRYAT) was approved in august 2017 and is co-funded by the European Union. The projects total duration is 35 months and the participants are teachers, researchers and students from three vocational schools and Research/University Institutes in France, Germany and Italy.The project is going to end next August 2020. Here we present the final report on the achieved objectives.The main research goal of TRYAT is a combination of processing and analysis of Global Navigation Satellite Systems (GNSS) data and monitoring of environmental parameters for vocational education and training (VET). Permanent high-precision GNSS stations currently operate for geodetic purposes, e.g. geodynamics, earthquake and volcano monitoring, etc. We want to capitalize and highly disseminate the fact that they also offer a reliable tool for remote sensing the atmospheric water vapour. Three professional GNSS stations and low-cost weather stations have been installed on the roof of the buildings of Lycée Saint Cricq (Pau, France), Lise-Meitner-Schule (Berlin, Germany) and Istituto Leonardo da Vinci (Naples, Italy).We show the achievements so far for each expected intellectual Output (O).O1- Learning Plattform.The Learning Web Platform is an interactive and versatile tool. It helps learners, teachers, researchers and other involved personnel to crosslink, enhance intercultural teambuilding and work on the related technological and environmental issues. The platform gives even access to online real-time and archived data, maps, evaluation and graphical visualization.O2- Starter Kit.We have been realizing a starter kit of a system to acquire and manage data from both GNSS and weather stations. The kit enables us testing not only the technology, but even the concept itself.O3- OER Learning Material ‘Physical and Technical Foundations’.It is an interactive physics course where students learn the foundations of three relevant main topics of the project: satellite technology, propagation of waves and physics of the atmosphere. The corresponding competences are elaborated for the use in different VET curricula.O4- OER Learning Material 'Informatics and Electrical Engineering'.We have developed an interactive learning unit (“learning environment”) with focus on informatics and electronics. The students are given just a problem, namely the collecting of environmental data. This problem is proposed to them in the form of an order from industry “Monitoring of renewable energy plant – measuring wind and sun strength as well as the electrical power”.O5- Educational videos.A series of 5-minute long videos have been realizing in all the official languages of the participating countries. The videos deal with the scientific subjects pertaining the project and report on the results themselves, and the way the student worked as teams to achieve them. Different subtopics will be presented in short videos, as a desirable way of dissemination.

Extracellular matrix (ECM) biomarkers such as matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) are pathophysiological key, prognostic marker and therapeutic target in chronic heart failure (HF). Serial measurements of MMPs and TIMPs may be useful for guidance of these applications. However, interpretation of time-dependent changes requires knowledge about the biological variation of ECM biomarkers. We performed measurements of MMP-2, MMP-9, TIMP-1, and TIMP-4 in 50 patients with chronic HF who met rigid criteria for clinical stability at 3-h, 6-h, 1-week and 2-week time intervals. In addition, clinical and haemodynamic assessment was performed at baseline, at 1- and 2-week intervals. Haemodynamic variables were measured using inert gas rebreathing and impedance cardiography. Heart rhythm was monitored with external ECG event recorders throughout the complete study. Reference change values (RCVs) and minimal important differences (MIDs) were determined for MMP-2, MMP-9, TIMP-1, and TIMP-4. Clinical and haemodynamic variables were stable over time. Depending on the time-interval, RCVs ranged between 4.9 and 11.7% for MMP-2, 26.4 and 56.7% for MMP-9, 10.8 and 30.7% for TIMP-1, and 16.0 and 47.4% for TIMP-4, respectively. The MIDs varied between 43.38 and 65.22 ng/ml for MMP-2, 28.71 and 40.96 ng/ml for MMP-9, 52.32 and 156.07 ng/ml for TIMP-1, and 293.92 and 798.04 pg/ml for TIMP-4, respectively. The biological variation of ECM biomarkers differs with respect to individual biomarkers and time intervals. MMP-2 may be most suitable for serial biomarker measurements, as the biological variation is low irrespective of the time interval between measurements.