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1. Machine learning-enabled maternal risk assessment for women with pre-eclampsia (the PIERS-ML model): a modelling study

Author

Brown, Mark A., Davis, Gregory K., Parker, Claire, Walters, Barry N., Sass, Nelson, Ansermino, J. Mark, Cao, Vivien, Cundiff, Geoffrey W., von Dadelszen, Emma C.M., Douglas, M. Joanne, Dumont, Guy A., Dunsmuir, Dustin T., Hutcheon, Jennifer A., Joseph, K.S., Lalji, Sayrin, Lee, Tang, Li, Jing, Lim, Kenneth I., Lisonkova, Sarka, Lott, Paula, Menzies, Jennifer M., Millman, Alexandra L., Palmer, Lynne, Payne, Beth A., Qu, Ziguang, Russell, James A., Sawchuck, Diane, Shaw, Dorothy, Still, D. Keith, Ukah, U. Vivian, Wagner, Brenda, Walley, Keith R., Hugo, Dany, Gruslin, The late Andrée, Tawagi, George, Smith, Graeme N., Côté, Anne-Marie, Moutquin, Jean-Marie, Ouellet, Annie B., Lee, Shoo K., Duan, Tao, Zhou, Jian, Haniff, The late Farizah, Mahajan, Swati, Noovao, Amanda, Karjalainend, Hanna, Kortelainen, Alja, Laivuori, Hannele, Ganzevoort, J. Wessel, Groen, Henk, Kyle, Phillipa M., Moore, M. Peter, Pullar, Barbra, Bhutta, Zulfiqar A., Qureshi, Rahat N., Sikandar, Rozina, Bhutta, The late Shereen Z., Cloete, Garth, Hall, David R., van Papendorp, The late Erika, Steyn, D. Wilhelm, Biryabarema, Christine, Mirembe, Florence, Nakimuli, Annettee, Allotey, John, Thangaratinam, Shakila, Nicolaides, Kypros H., Ionescu, Olivia, Syngelaki, Argyro, de Swiet, Michael, Magee, Laura A., von Dadelszen, Peter, Akolekar, Ranjit, Walker, James J., Robson, Stephen C., Broughton-Pipkin, Fiona, Loughna, Pamela, Vatish, Manu, Redman, Christopher W.G., Barry, Sarah J.E., Kavanagh, Kimberley, Montgomery-Csobán, Tunde, Murray, Paul, Robertson, Chris, Tsigas, Eleni Z., Woelkers, Douglas A., Lindheimer, Marshall D., Grobman, William A., Sibai, Baha M., Merialdi, Mario, Widmer, Mariana, Montgomery-Csobán, Tünde, Barry, Sarah J E, Vivian Ukah, U, Payne, Beth A, Nicolaides, Kypros H, Hutcheon, Jennifer A, and Magee, Laura A

Published
2024
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3. Strategies for optimising early detection and obstetric first response management of postpartum haemorrhage at caesarean birth: a modified Delphi-based international expert consensus

Author

Pingray, Verónica, primary, Williams, Caitlin R, additional, Al-beity, Fadhlun M Alwy, additional, Abalos, Edgardo, additional, Arulkumaran, Sabaratnam, additional, Blumenfeld, Alejandro, additional, Carvalho, Brendan, additional, Deneux-Tharaux, Catherine, additional, Downe, Soo, additional, Dumont, Alexandre, additional, Escobar, Maria Fernanda, additional, Evans, Cherrie, additional, Fawcus, Sue, additional, Galadanci, Hadiza S, additional, Hoang, Diem-Tuyet Thi, additional, Hofmeyr, G Justus, additional, Homer, Caroline, additional, Lewis, Ayodele G, additional, Liabsuetrakul, Tippawan, additional, Lumbiganon, Pisake, additional, Main, Elliott K, additional, Maua, Judith, additional, Muriithi, Francis G, additional, Nabhan, Ashraf Fawzy, additional, Nunes, Inês, additional, Ortega, Vanesa, additional, Phan, Thuan N Q, additional, Qureshi, Zahida P, additional, Sosa, Claudio, additional, Varallo, John, additional, Weeks, Andrew D, additional, Widmer, Mariana, additional, Oladapo, Olufemi T, additional, Gallos, Ioannis, additional, Coomarasamy, Arri, additional, Miller, Suellen, additional, and Althabe, Fernando, additional

Published
2024
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4. Effects of race and ethnicity on perinatal outcomes in high-income and upper-middle-income countries: an individual participant data meta-analysis of 2 198 655 pregnancies

Author

Abdollahain, Mali, Savitri, Ary I., Salvesen, Kjell Åsmund, Bhattacharya, Sohinee, Uiterwaal, Cuno S.P.M., Staff, Annetine C., Andersen, Louise Bjoerkholt, Olive, Elisa Llurba, Daskalakis, George, Macleod, Maureen, Thilaganathan, Baskaran, Ramírez, Javier Arenas, Massé, Jacques, Audibert, Francois, Magnus, Per Minor, Sletner, Line, Baschat, Ahmet, Ohkuchi, Akihide, McAuliffe, Fionnuala M., West, Jane, Askie, Lisa M., Mone, Fionnuala, Farrar, Diane, Zimmerman, Peter A., Smits, Luc J.M., Riddell, Catherine, Kingdom, John C., van de Post, Joris, Illanes, Sebastián E., Holzman, Claudia, van Kuijk, Sander M.J., Carbillon, Lionel, Villa, Pia M., Eskild, Anne, Chappell, Lucy, Prefumo, Federico, Velauthar, Luxmi, Seed, Paul, van Oostwaard, Miriam, Verlohren, Stefan, Poston, Lucilla, Ferrazzi, Enrico, Vinter, Christina A., Nagata, Chie, Brown, Mark, Vollebregt, Karlijn C., Takeda, Satoru, Langenveld, Josje, Widmer, Mariana, Saito, Shigeru, Haavaldsen, Camilla, Carroli, Guillermo, Olsen, Jørn, Wolf, Hans, Zavaleta, Nelly, Eisensee, Inge, Vergani, Patrizia, Lumbiganon, Pisake, Makrides, Maria, Facchinetti, Fabio, Sequeira, Evan, Gibson, Robert, Ferrazzani, Sergio, Frusca, Tiziana, Figueiró-Filho, Ernesto A., Lapaire, Olav, Laivuori, Hannele, Lykke, Jacob A., Conde-Agudelo, Agustin, Galindo, Alberto, Mbah, Alfred, Betran, Ana Pilar, Herraiz, Ignacio, Trogstad, Lill, Smith, Gordon G.S., Steegers, Eric A.P., Salim, Read, Huang, Tianhua, Adank, Annemarijne, Zhang, Jun, Meschino, Wendy S., Browne, Joyce L., Allen, Rebecca E., Da Silva Costa, Fabricio, Klipstein-Grobusch, Kerstin, Jørgensen, Jan Stener, Forest, Jean-Claude, Rumbold, Alice R., Mol, Ben W., Giguère, Yves, Ganzevoort, Wessel, Odibo, Anthony O., Myers, Jenny, Yeo, SeonAe, Teede, Helena J., Goffinet, Francois, McCowan, Lesley, Pajkrt, Eva, Haddad, Bassam G., Dekker, Gustaaf, Kleinrouweler, Emily C., LeCarpentier, Édouard, Roberts, Claire T., Groen, Henk, Skråstad, Ragnhild Bergene, Heinonen, Seppo, Eero, Kajantie, Kenny, Louise C., Anggraini, Dewi, Souka, Athena, Cecatti, Jose, Monterio, Ilza, Coomarasamy, Arri, Smuk, Melanie, Pillalis, Athanasios, Crovetto, Francesca, Souza, Renato, Ann Hawkins, Lee, Gabbay- Benziv, Rinat, Riley, Richard, Snell, Kym, Archer, Lucinda, Figuera, Francesc, van Gelder, Marleen, Sheikh, Jameela, Allotey, John, Kew, Tania, Fernández-Félix, Borja M, Zamora, Javier, Khalil, Asma, and Thangaratinam, Shakila

Published
2022
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6. Machine learning-enabled maternal risk assessment for women with pre-eclampsia (the PIERS-ML model): a modelling study

Author

Montgomery-Csobán, Tünde, primary, Kavanagh, Kimberley, additional, Murray, Paul, additional, Robertson, Chris, additional, Barry, Sarah J E, additional, Vivian Ukah, U, additional, Payne, Beth A, additional, Nicolaides, Kypros H, additional, Syngelaki, Argyro, additional, Ionescu, Olivia, additional, Akolekar, Ranjit, additional, Hutcheon, Jennifer A, additional, Magee, Laura A, additional, von Dadelszen, Peter, additional, Brown, Mark A., additional, Davis, Gregory K., additional, Parker, Claire, additional, Walters, Barry N., additional, Sass, Nelson, additional, Ansermino, J. Mark, additional, Cao, Vivien, additional, Cundiff, Geoffrey W., additional, von Dadelszen, Emma C.M., additional, Douglas, M. Joanne, additional, Dumont, Guy A., additional, Dunsmuir, Dustin T., additional, Hutcheon, Jennifer A., additional, Joseph, K.S., additional, Lalji, Sayrin, additional, Lee, Tang, additional, Li, Jing, additional, Lim, Kenneth I., additional, Lisonkova, Sarka, additional, Lott, Paula, additional, Menzies, Jennifer M., additional, Millman, Alexandra L., additional, Palmer, Lynne, additional, Payne, Beth A., additional, Qu, Ziguang, additional, Russell, James A., additional, Sawchuck, Diane, additional, Shaw, Dorothy, additional, Still, D. Keith, additional, Ukah, U. Vivian, additional, Wagner, Brenda, additional, Walley, Keith R., additional, Hugo, Dany, additional, Gruslin, The late Andrée, additional, Tawagi, George, additional, Smith, Graeme N., additional, Côté, Anne-Marie, additional, Moutquin, Jean-Marie, additional, Ouellet, Annie B., additional, Lee, Shoo K., additional, Duan, Tao, additional, Zhou, Jian, additional, Haniff, The late Farizah, additional, Mahajan, Swati, additional, Noovao, Amanda, additional, Karjalainend, Hanna, additional, Kortelainen, Alja, additional, Laivuori, Hannele, additional, Ganzevoort, J. Wessel, additional, Groen, Henk, additional, Kyle, Phillipa M., additional, Moore, M. Peter, additional, Pullar, Barbra, additional, Bhutta, Zulfiqar A., additional, Qureshi, Rahat N., additional, Sikandar, Rozina, additional, Bhutta, The late Shereen Z., additional, Cloete, Garth, additional, Hall, David R., additional, van Papendorp, The late Erika, additional, Steyn, D. Wilhelm, additional, Biryabarema, Christine, additional, Mirembe, Florence, additional, Nakimuli, Annettee, additional, Allotey, John, additional, Thangaratinam, Shakila, additional, Nicolaides, Kypros H., additional, de Swiet, Michael, additional, Magee, Laura A., additional, Walker, James J., additional, Robson, Stephen C., additional, Broughton-Pipkin, Fiona, additional, Loughna, Pamela, additional, Vatish, Manu, additional, Redman, Christopher W.G., additional, Barry, Sarah J.E., additional, Montgomery-Csobán, Tunde, additional, Tsigas, Eleni Z., additional, Woelkers, Douglas A., additional, Lindheimer, Marshall D., additional, Grobman, William A., additional, Sibai, Baha M., additional, Merialdi, Mario, additional, and Widmer, Mariana, additional

Published
2024
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10. Randomized Trial of Early Detection and Treatment of Postpartum Hemorrhage

Author

Gallos, Ioannis, primary, Devall, Adam, additional, Martin, James, additional, Middleton, Lee, additional, Beeson, Leanne, additional, Galadanci, Hadiza, additional, Alwy Al-beity, Fadhlun, additional, Qureshi, Zahida, additional, Hofmeyr, G. Justus, additional, Moran, Neil, additional, Fawcus, Sue, additional, Sheikh, Lumaan, additional, Gwako, George, additional, Osoti, Alfred, additional, Aswat, Ashraf, additional, Mammoliti, Kristie-Marie, additional, Sindhu, Kulandaipalayam N., additional, Podesek, Marcelina, additional, Horne, Isobelle, additional, Timms, Rebecca, additional, Yunas, Idnan, additional, Okore, Jenipher, additional, Singata-Madliki, Mandisa, additional, Arends, Edna, additional, Wakili, Aminu A., additional, Mwampashi, Ard, additional, Nausheen, Sidrah, additional, Muhammad, Shah, additional, Latthe, Pallavi, additional, Evans, Cherrie, additional, Akter, Shahinoor, additional, Forbes, Gillian, additional, Lissauer, David, additional, Meher, Shireen, additional, Weeks, Andrew, additional, Shennan, Andrew, additional, Ammerdorffer, Anne, additional, Williams, Eleanor, additional, Roberts, Tracy, additional, Widmer, Mariana, additional, Oladapo, Olufemi T., additional, Lorencatto, Fabiana, additional, Bohren, Meghan A., additional, Miller, Suellen, additional, Althabe, Fernando, additional, Gülmezoglu, Metin, additional, Smith, Jeffrey M., additional, Hemming, Karla, additional, and Coomarasamy, Arri, additional

Published
2023
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13. Correction: The World Health Organization Fetal Growth Charts: A Multinational Longitudinal Study of Ultrasound Biometric Measurements and Estimated Fetal Weight

Author

Kiserud, Torvid, Piaggio, Gilda, Carroli, Guillermo, Widmer, Mariana, Carvalho, José, Jensen, Lisa Neerup, Giordano, Daniel, Cecatti, José Guilherme, Aleem, Hany Abdel, Talegawkar, Sameera A., Benachi, Alexandra, Diemert, Anke, Kitoto, Antoinette Tshefu, Thinkhamrop, Jadsada, Lumbiganon, Pisake, Tabor, Ann, Kriplani, Alka, Perez, Rogelio Gonzalez, Hecher, Kurt, Hanson, Mark A., Gülmezoglu, A. Metin, and Platt, Lawrence D.

Subjects
Biological sciences
Abstract

Author(s): Torvid Kiserud, Gilda Piaggio, Guillermo Carroli, Mariana Widmer, José Carvalho, Lisa Neerup Jensen, Daniel Giordano, José Guilherme Cecatti, Hany Abdel Aleem, Sameera A. Talegawkar, Alexandra Benachi, Anke Diemert, Antoinette [...]

Published
2021
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16. Heat-Stable Carbetocin Versus Oxytocin to Prevent Hemorrhage After Vaginal Birth

Author

Widmer, Mariana, Piaggio, Gilda, Nguyen, Thi M. H., Osoti, Alfred, Owa, Olorunfemi O., Misra, Sujata, Coomarasamy, Arri, Abdel-Aleem, Hany, Mallapur, Ashalata A., Qureshi, Zahida, Lumbiganon, Pisake, Patel, Archana B., Carroli, Guillermo, Fawole, Bukola, Goudar, Shivaprasad S., Pujar, Yeshita V., Neilson, James, Hofmeyr, G. Justus, Su, Lin L., Ferreira de Carvalho, Jose, Pandey, Uma, Mugerwa, Kidza, Shiragur, Shobha S., Byamugisha, Josaphat, Giordano, Daniel, and Gülmezoglu, A. Metin

Published
2018
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18. Breakdown of simple female genital fistula repair after 7 day versus 14 day postoperative bladder catheterisation: a randomised, controlled, open-label, non-inferiority trial

Author

Barone, Mark A, Widmer, Mariana, Arrowsmith, Steven, Ruminjo, Joseph, Seuc, Armando, Landry, Evelyn, Barry, Thierno Hamidou, Danladi, Dantani, Djangnikpo, Lucien, Gbawuru-Mansaray, Tagie, Harou, Issoufa, Lewis, Alyona, Muleta, Mulu, Nembunzu, Dolorès, Olupot, Robert, Sunday-Adeoye, Ileogben, Wakasiaka, Weston Khisa, Landoulsi, Sihem, Delamou, Alexandre, Were, Lilian, Frajzyngier, Vera, Beattie, Karen, and Gülmezoglu, A Metin

Published
2015
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19. Effects of race and ethnicity on perinatal outcomes in high-income and upper-middle-income countries: an individual participant data meta-analysis of 2 198 655 pregnancies

Author

Sheikh, Jameela, primary, Allotey, John, additional, Kew, Tania, additional, Fernández-Félix, Borja M, additional, Zamora, Javier, additional, Khalil, Asma, additional, Thangaratinam, Shakila, additional, Abdollahain, Mali, additional, Savitri, Ary I., additional, Salvesen, Kjell Åsmund, additional, Bhattacharya, Sohinee, additional, Uiterwaal, Cuno S.P.M., additional, Staff, Annetine C., additional, Andersen, Louise Bjoerkholt, additional, Olive, Elisa Llurba, additional, Daskalakis, George, additional, Macleod, Maureen, additional, Thilaganathan, Baskaran, additional, Ramírez, Javier Arenas, additional, Massé, Jacques, additional, Audibert, Francois, additional, Magnus, Per Minor, additional, Sletner, Line, additional, Baschat, Ahmet, additional, Ohkuchi, Akihide, additional, McAuliffe, Fionnuala M., additional, West, Jane, additional, Askie, Lisa M., additional, Mone, Fionnuala, additional, Farrar, Diane, additional, Zimmerman, Peter A., additional, Smits, Luc J.M., additional, Riddell, Catherine, additional, Kingdom, John C., additional, van de Post, Joris, additional, Illanes, Sebastián E., additional, Holzman, Claudia, additional, van Kuijk, Sander M.J., additional, Carbillon, Lionel, additional, Villa, Pia M., additional, Eskild, Anne, additional, Chappell, Lucy, additional, Prefumo, Federico, additional, Velauthar, Luxmi, additional, Seed, Paul, additional, van Oostwaard, Miriam, additional, Verlohren, Stefan, additional, Poston, Lucilla, additional, Ferrazzi, Enrico, additional, Vinter, Christina A., additional, Nagata, Chie, additional, Brown, Mark;, additional, Vollebregt, Karlijn C., additional, Takeda, Satoru, additional, Langenveld, Josje, additional, Widmer, Mariana, additional, Saito, Shigeru, additional, Haavaldsen, Camilla, additional, Carroli, Guillermo, additional, Olsen, Jørn, additional, Wolf, Hans, additional, Zavaleta, Nelly, additional, Eisensee, Inge, additional, Vergani, Patrizia, additional, Lumbiganon, Pisake, additional, Makrides, Maria, additional, Facchinetti, Fabio, additional, Sequeira, Evan, additional, Gibson, Robert, additional, Ferrazzani, Sergio, additional, Frusca, Tiziana, additional, Figueiró-Filho, Ernesto A., additional, Lapaire, Olav, additional, Laivuori, Hannele, additional, Lykke, Jacob A., additional, Conde-Agudelo, Agustin, additional, Galindo, Alberto, additional, Mbah, Alfred, additional, Betran, Ana Pilar, additional, Herraiz, Ignacio, additional, Trogstad, Lill, additional, Smith, Gordon G.S., additional, Steegers, Eric A.P., additional, Salim, Read, additional, Huang, Tianhua, additional, Adank, Annemarijne, additional, Zhang, Jun, additional, Meschino, Wendy S., additional, Browne, Joyce L., additional, Allen, Rebecca E., additional, Da Silva Costa, Fabricio, additional, Klipstein-Grobusch, Kerstin, additional, Jørgensen, Jan Stener, additional, Forest, Jean-Claude, additional, Rumbold, Alice R., additional, Mol, Ben W., additional, Giguère, Yves, additional, Ganzevoort, Wessel, additional, Odibo, Anthony O., additional, Myers, Jenny, additional, Yeo, SeonAe, additional, Teede, Helena J., additional, Goffinet, Francois, additional, McCowan, Lesley, additional, Pajkrt, Eva, additional, Haddad, Bassam G., additional, Dekker, Gustaaf, additional, Kleinrouweler, Emily C., additional, LeCarpentier, Édouard, additional, Roberts, Claire T., additional, Groen, Henk, additional, Skråstad, Ragnhild Bergene, additional, Heinonen, Seppo, additional, Eero, Kajantie, additional, Kenny, Louise C., additional, Anggraini, Dewi, additional, Souka, Athena, additional, Cecatti, Jose, additional, Monterio, Ilza, additional, Coomarasamy, Arri, additional, Smuk, Melanie, additional, Pillalis, Athanasios, additional, Crovetto, Francesca, additional, Souza, Renato, additional, Ann Hawkins, Lee, additional, Gabbay- Benziv, Rinat, additional, Riley, Richard, additional, Snell, Kym, additional, Archer, Lucinda, additional, Figuera, Francesc, additional, and van Gelder, Marleen, additional

Published
2022
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20. sj-pdf-1-ctj-10.1177_17407745221136527 – Supplemental material for Treatment selection in multi-arm multi-stage designs: With application to a postpartum haemorrhage trial

Author

Choodari-Oskooei, Babak, Thwin, Soe Soe, Blenkinsop, Alexandra, Widmer, Mariana, Althabe, Fernando, and Parmar, Mahesh KB

Subjects
FOS: Clinical medicine, 160807 Sociological Methodology and Research Methods, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, FOS: Sociology
Abstract

Supplemental material, sj-pdf-1-ctj-10.1177_17407745221136527 for Treatment selection in multi-arm multi-stage designs: With application to a postpartum haemorrhage trial by Babak Choodari-Oskooei, Soe Soe Thwin, Alexandra Blenkinsop, Mariana Widmer, Fernando Althabe and Mahesh KB Parmar in Clinical Trials

Published
2023
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21. Tranexamic acid at cesarean delivery: Drug‐error deaths

Author

Moran, Neil F., primary, Bishop, David G., additional, Fawcus, Susan, additional, Morris, Edward, additional, Shakur‐Still, Haleema, additional, Devall, Adam J., additional, Gallos, Ioannis D., additional, Widmer, Mariana, additional, Oladapo, Olufemi T., additional, Coomarasamy, Arri, additional, and Hofmeyr, G. Justus, additional

Published
2022
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22. Active management of the third stage of labour with and without controlled cord traction: a randomised, controlled, non-inferiority trial

Author

Gülmezoglu, A Metin, Lumbiganon, Pisake, Landoulsi, Sihem, Widmer, Mariana, Abdel-Aleem, Hany, Festin, Mario, Carroli, Guillermo, Qureshi, Zahida, Souza, João Paulo, Bergel, Eduardo, Piaggio, Gilda, Goudar, Shivaprasad S, Yeh, John, Armbruster, Deborah, Singata, Mandisa, Pelaez-Crisologo, Cristina, Althabe, Fernando, Sekweyama, Peter, Hofmeyr, Justus, Stanton, Mary-Ellen, Derman, Richard, and Elbourne, Diana

Published
2012
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24. Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS model

Author

von Dadelszen, Peter, Payne, Beth, Li, Jing, Ansermino, J Mark, Pipkin, Fiona Broughton, Côté, Anne-Marie, Douglas, M Joanne, Gruslin, Andrée, Hutcheon, Jennifer A, Joseph, KS, Kyle, Phillipa M, Lee, Tang, Loughna, Pamela, Menzies, Jennifer M, Merialdi, Mario, Millman, Alexandra L, Moore, M Peter, Moutquin, Jean-Marie, Ouellet, Annie B, Smith, Graeme N, Walker, James J, Walley, Keith R, Walters, Barry N, Widmer, Mariana, Lee, Shoo K, Russell, James A, and Magee, Laura A

Published
2011
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26. Duration of third stage labour and postpartum blood loss: a secondary analysis of the WHO CHAMPION trial data

Author

Chikkamath, Sumangala B., primary, Katageri, Geetanjali M., additional, Mallapur, Ashalata A., additional, Vernekar, Sunil S., additional, Somannavar, Manjunath S., additional, Piaggio, Gilda, additional, Carroli, Guillermo, additional, de Carvalho, José Ferreira, additional, Althabe, Fernando, additional, Hofmeyr, G. Justus, additional, Widmer, Mariana, additional, Gulmezoglu, Ahmet Metin, additional, and Goudar, Shivaprasad S., additional

Published
2021
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27. Effect of heat stable carbetocin vs oxytocin for preventing postpartum haemorrhage on post delivery hemoglobin–a randomized controlled trial.

Author

Vernekar, Sunil S., primary, Goudar, Swati S., additional, Metgud, Mrityunjay, additional, Pujar, Yeshita V., additional, Somannavar, Manjunath S., additional, Piaggio, Gilda, additional, Carvalho, José Ferreira D. E., additional, Revankar, Amit, additional, Althabe, Fernando, additional, Widmer, Mariana, additional, Gulmezoglu, Ahmet Metin, additional, and Goudar, Shivaprasad S., additional

Published
2021
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28. Effect of heat stable carbetocin vs oxytocin for preventing postpartum haemorrhage on post delivery hemoglobin–a randomized controlled trial.

Author

Vernekar, Sunil S., Goudar, Swati S., Metgud, Mrityunjay, Pujar, Yeshita V., Somannavar, Manjunath S., Piaggio, Gilda, Carvalho, José Ferreira D. E., Revankar, Amit, Althabe, Fernando, Widmer, Mariana, Gulmezoglu, Ahmet Metin, and Goudar, Shivaprasad S.

Subjects
POSTPARTUM hemorrhage, OXYTOCIN, INDUCED labor (Obstetrics), DELIVERY (Obstetrics), INTRAMUSCULAR injections, RANDOMIZED controlled trials
Abstract

Objective To compare the effect of heat-stable carbetocin 100 μg IM versus oxytocin 10 IU IM on post-delivery hemoglobin level. Setting Hospital based study in Southern India. Population Women delivering vaginally who were enrolled in the WHO CHAMPION trial in a single facility in India. WHO CHAMPION Trial was a randomized, double-blind, noninferiority trial comparing intramuscular injections of heat-stable carbetocin with oxytocin administered immediately after vaginal birth in women across 23 sites in 10 countries. Methods This was a nested randomized controlled trial designed to compare the effect of heat-stable carbetocin 100 μg IM versus oxytocin 10 IU IM, administered within one minute of vaginal delivery of the baby for prevention of postpartum hemorrhage, on post-delivery 48–72 h hemoglobin level, adjusted for pre-delivery hemoglobin level. 1,799 women from one hospital in India participated in this study. Results Pre-delivery hemoglobin and postpartum blood loss were not significantly different between carbetocin and oxytocin. Post-delivery hemoglobin, unadjusted or adjusted for pre-delivery hemoglobin, was slightly lower for carbetocin (10.09 g/dL) compared to oxytocin (10.21) (p value of 0.0432). The drop in hemoglobin was slightly higher for carbetocin, although the difference was very small (1.2 g/dL for carbetocin, 1.1 g/dL for oxytocin) (p value of .0786). The proportion of participants with a drop in hemoglobin of 2 g/dL or more, adjusted for pre-delivery hemoglobin, was higher for carbetocin (RR = 1.29, 95% CI 1.02–1.63). From the regression coefficients it can be derived that post-delivery hemoglobin, adjusted for pre-delivery hemoglobin, decreases on average 0.12 g/dL for each dL of blood lost, for the two treatments combined. Conclusion The present ancillary study showed that intramuscular administration of 100 µg of heat stable carbetocin can result in a slightly lower post-delivery hemoglobin, slightly higher drop and higher percentage of women having a drop of 2 g/dL or larger, compared to 10 IU of oxytocin. [ABSTRACT FROM AUTHOR]

Published
2022
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32. Duration of Third Stage Labour and Postpartum Blood Loss: a Secondary Analysis of the WHO CHAMPION Trial Data

Author

Chikkamath, Sumangala B, primary, Katageri, Geetanjali M, additional, Mallapur, Ashalata A, additional, Vernekar, Sunil S, additional, Somannavar, Manjunath S, additional, Piaggio, Gilda, additional, Carroli, Guillermo, additional, de Carvalho, José Ferreira, additional, Althabe, Fernando, additional, Hofmeyr, G Justus, additional, Widmer, Mariana, additional, Gulmezoglu, Ahmet Metin, additional, and Goudar, Shivaprasad S, additional

Published
2021
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33. Effect of Heat stable Carbetocin vs Oxytocin for Preventing Postpartum Haemorrhage on Post Delivery Hemoglobin- A Randomized Controlled Trial

Author

Vernekar, Sunil S, primary, Goudar, Swati S, additional, Metgud, Mrityunjay C, additional, Pujar, Yeshita V, additional, Somannavar, Manjunath S, additional, Piaggio, Gilda, additional, de Carvalho, José Ferreira, additional, Revankar, Amit, additional, Althabe, Fernando, additional, Widmer, Mariana, additional, Gulmezoglu, Ahmet Metin, additional, and Goudar, Shivaprasad S, additional

Published
2021
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35. Healthcare providers experiences of using uterine balloon tamponade (UBT) devices for the treatment of post-partum haemorrhage: A meta-synthesis of qualitative studies

Author

Finlayson, Kenneth William, Vogel, Joshua P., Althabe, Fernando, Widmer, Mariana, Oladapo, Olufemi T., Finlayson, Kenneth William, Vogel, Joshua P., Althabe, Fernando, Widmer, Mariana, and Oladapo, Olufemi T.

Abstract

Background: Postpartum haemorrhage (PPH) is a leading cause of maternal mortality and severe morbidity globally. When PPH cannot be controlled using standard medical treatments, uterine balloon tamponade (UBT) may be used to arrest bleeding. While UBT is used by healthcare providers in hospital settings internationally, their views and experiences have not been systematically explored. The aim of this review is to identify, appraise and synthesize available evidence about the views and experiences of healthcare providers using UBT to treat PPH. Methods: Using a pre-determined search strategy, we searched MEDLINE, CINAHL, PsycINFO, EMBASE, LILACS, AJOL, and reference lists of eligible studies published 1996–2019, reporting qualitative data on the views and experiences of health professionals using UBT to treat PPH. Author findings were extracted and synthesised using techniques derived from thematic synthesis and confidence in the findings was assessed using GRADE-CERQual. Results: Out of 89 studies we identified 5 that met our inclusion criteria. The studies were conducted in five low- and middle-income countries (LMICs) in Africa and reported on the use of simple UBT devices for the treatment of PPH. A variety of cadres (including midwives, medical officers and clinical officers) had experience with using UBTs and found them to be effective, convenient, easy to assemble and relatively inexpensive. Providers also suggested regular, hands-on training was necessary to maintain skills and highlighted the importance of community engagement in successful implementation. Conclusions: Providers felt that administration of a simple UBT device offered a practical and cost-effective approach to the treatment of uncontrolled PPH, especially in contexts where uterotonics were ineffective or unavailable or where access to surgery was not possible. The findings are limited by the relatively small number of studies contributing to the review and further research in other contexts

Published
2021

38. The World Health Organization Fetal Growth Charts: A Multinational Longitudinal Study of Ultrasound Biometric Measurements and Estimated Fetal Weight

Author

Kiserud, Torvid, Piaggio, Gilda, Carroli, Guillermo, Widmer, Mariana, Carvalho, José, Neerup Jensen, Lisa, Giordano, Daniel, Cecatti, José Guilherme, Abdel Aleem, Hany, Talegawkar, Sameera A., Benachi, Alexandra, Diemert, Anke, Tshefu Kitoto, Antoinette, Thinkhamrop, Jadsada, Lumbiganon, Pisake, Tabor, Ann, Kriplani, Alka, Gonzalez Perez, Rogelio, Hecher, Kurt, Hanson, Mark A., Gülmezoglu, A. Metin, and Platt, Lawrence D.

Subjects
Diagnostic ultrasonography -- Usage, Biometry -- Usage, Fetal development -- Statistics, Biometric technology, Biological sciences
Abstract

Background Perinatal mortality and morbidity continue to be major global health challenges strongly associated with prematurity and reduced fetal growth, an issue of further interest given the mounting evidence that fetal growth in general is linked to degrees of risk of common noncommunicable diseases in adulthood. Against this background, WHO made it a high priority to provide the present fetal growth charts for estimated fetal weight (EFW) and common ultrasound biometric measurements intended for worldwide use. Methods and Findings We conducted a multinational prospective observational longitudinal study of fetal growth in low-risk singleton pregnancies of women of high or middle socioeconomic status and without known environmental constraints on fetal growth. Centers in ten countries (Argentina, Brazil, Democratic Republic of the Congo, Denmark, Egypt, France, Germany, India, Norway, and Thailand) recruited participants who had reliable information on last menstrual period and gestational age confirmed by crown-rump length measured at 8-13 wk of gestation. Participants had anthropometric and nutritional assessments and seven scheduled ultrasound examinations during pregnancy. Fifty-two participants withdrew consent, and 1,387 participated in the study. At study entry, median maternal age was 28 y (interquartile range [IQR] 25-31), median height was 162 cm (IQR 157-168), median weight was 61 kg (IQR 55-68), 58% of the women were nulliparous, and median daily caloric intake was 1,840 cal (IQR 1,487-2,222). The median pregnancy duration was 39 wk (IQR 38-40) although there were significant differences between countries, the largest difference being 12 d (95% CI 8-16). The median birthweight was 3,300 g (IQR 2,980-3,615). There were differences in birthweight between countries, e.g., India had significantly smaller neonates than the other countries, even after adjusting for gestational age. Thirty-one women had a miscarriage, and three fetuses had intrauterine death. The 8,203 sets of ultrasound measurements were scrutinized for outliers and leverage points, and those measurements taken at 14 to 40 wk were selected for analysis. A total of 7,924 sets of ultrasound measurements were analyzed by quantile regression to establish longitudinal reference intervals for fetal head circumference, biparietal diameter, humerus length, abdominal circumference, femur length and its ratio with head circumference and with biparietal diameter, and EFW. There was asymmetric distribution of growth of EFW: a slightly wider distribution among the lower percentiles during early weeks shifted to a notably expanded distribution of the higher percentiles in late pregnancy. Male fetuses were larger than female fetuses as measured by EFW, but the disparity was smaller in the lower quantiles of the distribution (3.5%) and larger in the upper quantiles (4.5%). Maternal age and maternal height were associated with a positive effect on EFW, particularly in the lower tail of the distribution, of the order of 2% to 3% for each additional 10 y of age of the mother and 1% to 2% for each additional 10 cm of height. Maternal weight was associated with a small positive effect on EFW, especially in the higher tail of the distribution, of the order of 1.0% to 1.5% for each additional 10 kg of bodyweight of the mother. Parous women had heavier fetuses than nulliparous women, with the disparity being greater in the lower quantiles of the distribution, of the order of 1% to 1.5%, and diminishing in the upper quantiles. There were also significant differences in growth of EFW between countries. In spite of the multinational nature of the study, sample size is a limiting factor for generalization of the charts. Conclusions This study provides WHO fetal growth charts for EFW and common ultrasound biometric measurements, and shows variation between different parts of the world., Author(s): Torvid Kiserud 1,2,*, Gilda Piaggio 3,4,*, Guillermo Carroli 5, Mariana Widmer 6,*, José Carvalho 4, Lisa Neerup Jensen 7, Daniel Giordano 5, José Guilherme Cecatti 8, Hany Abdel Aleem [...]

Published
2017
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39. EFFECTIVENESS OF UTERINE TAMPONADE DEVICES FOR REFRACTORY POSTPARTUM HAEMORRHAGE AFTER VAGINAL BIRTH: A SYSTEMATIC REVIEW

Author

Pingray, Veronica, primary, Widmer, Mariana, additional, Ciapponi, Agustín, additional, Hofmeyr, GJ, additional, Deneux-Tharaux, Catherine, additional, Gulmezoglu, Ahmet, additional, Bloemenkamp, Kitty, additional, Oladapo, Olufemi, additional, Comande, Daniel, additional, Bardach, Ariel, additional, Vazquez, Paula, additional, Cormick, Gabriela, additional, and Althabe, Fernando, additional

Published
2020
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40. Uterotonic agents for first-line treatment of postpartum haemorrhage: a network meta-analysis

Author

Parry Smith, William R, additional, Papadopoulou, Argyro, additional, Thomas, Eleanor, additional, Tobias, Aurelio, additional, Price, Malcolm J, additional, Meher, Shireen, additional, Alfirevic, Zarko, additional, Weeks, Andrew D, additional, Hofmeyr, G Justus, additional, Gülmezoglu, Ahmet Metin, additional, Widmer, Mariana, additional, Oladapo, Olufemi T, additional, Vogel, Joshua P, additional, Althabe, Fernando, additional, Coomarasamy, Arri, additional, and Gallos, Ioannis D, additional

Published
2020
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43. EFFECTIVENESS OF UTERINE TAMPONADE DEVICES FOR REFRACTORY POSTPARTUM HAEMORRHAGE AFTER VAGINAL BIRTH: A SYSTEMATIC REVIEW AND META-ANALYSIS

Author

Pingray, Veronica, primary, Widmer, Mariana, additional, Ciapponi, Agust n, additional, Cormick, Gabriela, additional, Bloemenkamp, Kitty, additional, Tharaux, Catherine Deneux, additional, Gulmezoglu, Ahmet, additional, Hofmeyr, GJ, additional, Oladapo, Olufemi, additional, and Althabe, Fernando, additional

Published
2020
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47. Non-inferiority of short-term urethral catheterization following fistula repair surgery: study protocol for a randomized controlled trial

Author

Barone Mark A, Frajzyngier Vera, Arrowsmith Steven, Ruminjo Joseph, Seuc Armando, Landry Evelyn, Beattie Karen, Barry Thierno, Lewis Alyona, Muleta Mulu, Nembunzu Dolorès, Olupot Robert, Sunday-Adeoye Ileogben, Wakasiaka Weston, Widmer Mariana, and Gülmezoglu A Metin

Subjects
Vaginal fistula, Catheter, Non-inferiority randomized controlled trial, Surgery, Gynecology and obstetrics, RG1-991, Public aspects of medicine, RA1-1270
Abstract

Abstract Background A vaginal fistula is a devastating condition, affecting an estimated 2 million girls and women across Africa and Asia. There are numerous challenges associated with providing fistula repair services in developing countries, including limited availability of operating rooms, equipment, surgeons with specialized skills, and funding from local or international donors to support surgeries and subsequent post-operative care. Finding ways of providing services in a more efficient and cost-effective manner, without compromising surgical outcomes and the overall health of the patient, is paramount. Shortening the duration of urethral catheterization following fistula repair surgery would increase treatment capacity, lower costs of services, and potentially lower risk of healthcare-associated infections among fistula patients. There is a lack of empirical evidence supporting any particular length of time for urethral catheterization following fistula repair surgery. This study will examine whether short-term (7 day) urethral catheterization is not worse by more than a minimal relevant difference to longer-term (14 day) urethral catheterization in terms of incidence of fistula repair breakdown among women with simple fistula presenting at study sites for fistula repair service. Methods/Design This study is a facility-based, multicenter, non-inferiority randomized controlled trial (RCT) comparing the new proposed short-term (7 day) urethral catheterization to longer-term (14 day) urethral catheterization in terms of predicting fistula repair breakdown. The primary outcome is fistula repair breakdown up to three months following fistula repair surgery as assessed by a urinary dye test. Secondary outcomes will include repair breakdown one week following catheter removal, intermittent catheterization due to urinary retention and the occurrence of septic or febrile episodes, prolonged hospitalization for medical reasons, catheter blockage, and self-reported residual incontinence. This trial will be conducted among 512 women with simple fistula presenting at 8 study sites for fistula repair surgery over the course of 24 months at each site. Discussion If no major safety issues are identified, the data from this trial may facilitate adoption of short-term urethral catheterization following repair of simple fistula in sub-Saharan Africa and Asia. Trial registration ClinicalTrials.gov Identifier NCT01428830.

Published
2012
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48. Additional file 3: of Distribution of postpartum blood loss: modeling, estimation and application to clinical trials

Author

Carvalho, José, Piaggio, Gilda, Wojdyla, Daniel, Widmer, Mariana, and A. Gülmezoglu

Abstract

Table A3. Quantiles for the fitted three-parameter lognormal and empirical distributions, with 95% CI, by treatment (a: Misoprostol trial; b: Active Management trial; d: Althabe et al. trial), or aggregated treatments (c: CHAMPION trial). (PDF 145 kb)

Published
2018
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50. Additional file 2: of Distribution of postpartum blood loss: modeling, estimation and application to clinical trials

Author

Carvalho, José, Piaggio, Gilda, Wojdyla, Daniel, Widmer, Mariana, and A. Gülmezoglu

Abstract

Table A2. Goodness of fit statistics for the three-parameter lognormal and other distributions, by treatment (a: Misoprostol trial; b: Active Management trial; d: Althabe et al. trial), or aggregated treatments (c: CHAMPION trial). (PDF 134 kb)

Published
2018
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