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1. Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study

Author

Dixon-Suen, Suzanne C, Nagle, Christina M, Thrift, Aaron P, Pharoah, Paul DP, Ewing, Ailith, Pearce, Celeste Leigh, Zheng, Wei, Australian Ovarian Cancer Study Group, Chenevix-Trench, Georgia, Fasching, Peter A, Beckmann, Matthias W, Lambrechts, Diether, Vergote, Ignace, Lambrechts, Sandrina, Van Nieuwenhuysen, Els, Rossing, Mary Anne, Doherty, Jennifer A, Wicklund, Kristine G, Chang-Claude, Jenny, Jung, Audrey Y, Moysich, Kirsten B, Odunsi, Kunle, Goodman, Marc T, Wilkens, Lynne R, Thompson, Pamela J, Shvetsov, Yurii B, Dörk, Thilo, Park-Simon, Tjoung-Won, Hillemanns, Peter, Bogdanova, Natalia, Butzow, Ralf, Nevanlinna, Heli, Pelttari, Liisa M, Leminen, Arto, Modugno, Francesmary, Ness, Roberta B, Edwards, Robert P, Kelley, Joseph L, Heitz, Florian, du Bois, Andreas, Harter, Philipp, Schwaab, Ira, Karlan, Beth Y, Lester, Jenny, Orsulic, Sandra, Rimel, Bobbie J, Kjær, Susanne K, Høgdall, Estrid, Jensen, Allan, Goode, Ellen L, Fridley, Brooke L, Cunningham, Julie M, Winham, Stacey J, Giles, Graham G, Bruinsma, Fiona, Milne, Roger L, Southey, Melissa C, Hildebrandt, Michelle AT, Wu, Xifeng, Lu, Karen H, Liang, Dong, Levine, Douglas A, Bisogna, Maria, Schildkraut, Joellen M, Berchuck, Andrew, Cramer, Daniel W, Terry, Kathryn L, Bandera, Elisa V, Olson, Sara H, Salvesen, Helga B, Thomsen, Liv Cecilie Vestrheim, Kopperud, Reidun K, Bjorge, Line, Kiemeney, Lambertus A, Massuger, Leon FAG, Pejovic, Tanja, Bruegl, Amanda, Cook, Linda S, Le, Nhu D, Swenerton, Kenneth D, Brooks-Wilson, Angela, Kelemen, Linda E, Lubiński, Jan, Huzarski, Tomasz, Gronwald, Jacek, Menkiszak, Janusz, Wentzensen, Nicolas, Brinton, Louise, Yang, Hannah, Lissowska, Jolanta, Høgdall, Claus K, Lundvall, Lene, Song, Honglin, Tyrer, Jonathan P, Campbell, Ian, Eccles, Diana, Paul, James, Glasspool, Rosalind, Siddiqui, Nadeem, and Whittemore, Alice S

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Genetics, Women's Health, Cancer, Ovarian Cancer, Prevention, Rare Diseases, 2.1 Biological and endogenous factors, Adolescent, Adult, Aged, Aged, 80 and over, Body Height, Carcinoma, Ovarian Epithelial, Case-Control Studies, Female, Genetic Predisposition to Disease, Geography, Humans, Mendelian Randomization Analysis, Middle Aged, Ovarian Neoplasms, Risk Factors, Young Adult, Australian Ovarian Cancer Study Group, Ovarian Cancer Association Consortium, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundObservational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias.MethodsWe pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis.ResultsGreater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours.ConclusionsWomen with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.

Published
2018

2. Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies

Author

Præstegaard, Camilla, Jensen, Allan, Jensen, Signe M, Nielsen, Thor SS, Webb, Penelope M, Nagle, Christina M, DeFazio, Anna, Group, on behalf of the Australian Ovarian Cancer Study, Høgdall, Estrid, Rossing, Mary Anne, Doherty, Jennifer A, Wicklund, Kristine G, Goodman, Marc T, Modugno, Francesmary, Moysich, Kirsten, Ness, Roberta B, Edwards, Robert, Matsuo, Keitaro, Hosono, Satoyo, Goode, Ellen L, Winham, Stacey J, Fridley, Brooke L, Cramer, Daniel W, Terry, Kathryn L, Schildkraut, Joellen M, Berchuck, Andrew, Bandera, Elisa V, Paddock, Lisa E, Massuger, Leon F, Wentzensen, Nicolas, Pharoah, Paul, Song, Honglin, Whittemore, Alice, McGuire, Valerie, Sieh, Weiva, Rothstein, Joseph, Anton‐Culver, Hoda, Ziogas, Argyrios, Menon, Usha, Gayther, Simon A, Ramus, Susan J, Gentry‐Maharaj, Alexandra, Wu, Anna H, Pearce, Celeste L, Pike, Malcolm, Lee, Alice W, Sutphen, Rebecca, Chang‐Claude, Jenny, Risch, Harvey A, Kjaer, Susanne K, and Consortium, on behalf of the Ovarian Cancer Association

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Ovarian Cancer, Tobacco Smoke and Health, Tobacco, Cancer, Rare Diseases, Prevention, Adult, Aged, Aged, 80 and over, Carcinoma, Ovarian Epithelial, Case-Control Studies, Female, Humans, Middle Aged, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Proportional Hazards Models, Risk Factors, Smoking, Young Adult, cigarette smoking, ovarian cancer, survival, pooled analysis, Australian Ovarian Cancer Study Group, Ovarian Cancer Association Consortium, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Cigarette smoking is associated with an increased risk of developing mucinous ovarian tumors but whether it is associated with ovarian cancer survival overall or for the different histotypes is unestablished. Furthermore, it is unknown whether the association between cigarette smoking and survival differs according to strata of ovarian cancer stage at diagnosis. In a large pooled analysis, we evaluated the association between various measures of cigarette smoking and survival among women with epithelial ovarian cancer. We obtained data from 19 case-control studies in the Ovarian Cancer Association Consortium (OCAC), including 9,114 women diagnosed with ovarian cancer. Cox regression models were used to estimate adjusted study-specific hazard ratios (HRs), which were combined into pooled hazard ratios (pHR) with corresponding 95% confidence intervals (CIs) under random effects models. Overall, 5,149 (57%) women died during a median follow-up period of 7.0 years. Among women diagnosed with ovarian cancer, both current (pHR = 1.17, 95% CI: 1.08-1.28) and former smokers (pHR = 1.10, 95% CI: 1.02-1.18) had worse survival compared with never smoking women. In histotype-stratified analyses, associations were observed for mucinous (current smoking: pHR = 1.91, 95% CI: 1.01-3.65) and serous histotypes (current smoking: pHR = 1.11, 95% CI: 1.00-1.23; former smoking: pHR = 1.12, 95% CI: 1.04-1.20). Further, our results suggested that current smoking has a greater impact on survival among women with localized than disseminated disease. The identification of cigarette smoking as a modifiable factor associated with survival has potential clinical importance as a focus area to improve ovarian cancer prognosis.

Published
2017

3. Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium

Author

Dixon, Suzanne C, Nagle, Christina M, Wentzensen, Nicolas, Trabert, Britton, Beeghly-Fadiel, Alicia, Schildkraut, Joellen M, Moysich, Kirsten B, deFazio, Anna, Risch, Harvey A, Rossing, Mary Anne, Doherty, Jennifer A, Wicklund, Kristine G, Goodman, Marc T, Modugno, Francesmary, Ness, Roberta B, Edwards, Robert P, Jensen, Allan, Kjær, Susanne K, Høgdall, Estrid, Berchuck, Andrew, Cramer, Daniel W, Terry, Kathryn L, Poole, Elizabeth M, Bandera, Elisa V, Paddock, Lisa E, Anton-Culver, Hoda, Ziogas, Argyrios, Menon, Usha, Gayther, Simon A, Ramus, Susan J, Gentry-Maharaj, Aleksandra, Pearce, Celeste Leigh, Wu, Anna H, Pike, Malcolm C, and Webb, Penelope M

Subjects
Clinical Research, Cancer, Ovarian Cancer, Rare Diseases, Acetaminophen, Adult, Aged, Analgesics, Anti-Inflammatory Agents, Non-Steroidal, Anticarcinogenic Agents, Aspirin, Disease-Free Survival, Female, Humans, Middle Aged, Ovarian Neoplasms, Proportional Hazards Models, Risk Factors, ovarian cancer, aspirin, nonsteroidal anti-inflammatory drugs, NSAID, paracetamol, acetaminophen, pooled analysis, survival, Australian Ovarian Cancer Study Group, Oncology and Carcinogenesis, Public Health and Health Services, Oncology & Carcinogenesis
Abstract

BackgroundNonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with improved survival in some cancers, but evidence for ovarian cancer is limited.MethodsPooling individual-level data from 12 Ovarian Cancer Association Consortium studies, we evaluated the association between self-reported, pre-diagnosis use of common analgesics and overall/progression-free/disease-specific survival among 7694 women with invasive epithelial ovarian cancer (4273 deaths).ResultsRegular analgesic use (at least once per week) was not associated with overall survival (pooled hazard ratios, pHRs (95% confidence intervals): aspirin 0.96 (0.88-1.04); non-aspirin NSAIDs 0.97 (0.89-1.05); acetaminophen 1.01 (0.93-1.10)), nor with progression-free/disease-specific survival. There was however a survival advantage for users of any NSAIDs in studies clearly defining non-use as less than once per week (pHR=0.89 (0.82-0.98)).ConclusionsAlthough this study did not show a clear association between analgesic use and ovarian cancer survival, further investigation with clearer definitions of use and information about post-diagnosis use is warranted.

Published
2017

4. Pelvic Inflammatory Disease and the Risk of Ovarian Cancer and Borderline Ovarian Tumors: A Pooled Analysis of 13 Case-Control Studies

Author

Rasmussen, Christina B, Kjaer, Susanne K, Albieri, Vanna, Bandera, Elisa V, Doherty, Jennifer A, Høgdall, Estrid, Webb, Penelope M, Jordan, Susan J, Rossing, Mary Anne, Wicklund, Kristine G, Goodman, Marc T, Modugno, Francesmary, Moysich, Kirsten B, Ness, Roberta B, Edwards, Robert P, Schildkraut, Joellen M, Berchuck, Andrew, Olson, Sara H, Kiemeney, Lambertus A, Massuger, Leon FAG, Narod, Steven A, Phelan, Catherine M, Anton-Culver, Hoda, Ziogas, Argyrios, Wu, Anna H, Pearce, Celeste L, Risch, Harvey A, Jensen, Allan, and Consortium, on behalf of the Ovarian Cancer Association

Subjects
Epidemiology, Health Sciences, Rare Diseases, Clinical Research, Human Genome, Prevention, Ovarian Cancer, Genetics, Cancer, Carcinoma, Ovarian Epithelial, Case-Control Studies, Comorbidity, Contraceptives, Oral, Hormonal, Family Health, Female, Genetic Predisposition to Disease, Hormone Replacement Therapy, Humans, Hysterectomy, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Pelvic Inflammatory Disease, Protective Factors, Reproductive History, Risk Factors, Sterilization, Tubal, Talc, inflammation, neoplasms, histological type, ovarian neoplasms, pelvic inflammatory disease, risk factors, on behalf of the Ovarian Cancer Association Consortium, neoplasms, histological type, Mathematical Sciences, Medical and Health Sciences
Abstract

Inflammation has been implicated in ovarian carcinogenesis. However, studies investigating the association between pelvic inflammatory disease (PID) and ovarian cancer risk are few and inconsistent. We investigated the association between PID and the risk of epithelial ovarian cancer according to tumor behavior and histotype. We pooled data from 13 case-control studies, conducted between 1989 and 2009, from the Ovarian Cancer Association Consortium (OCAC), including 9,162 women with ovarian cancers, 2,354 women with borderline tumors, and 14,736 control participants. Study-specific odds ratios were estimated and subsequently combined into a pooled odds ratio using a random-effects model. A history of PID was associated with an increased risk of borderline tumors (pooled odds ratio (pOR) = 1.32, 95% confidence interval (CI): 1.10, 1.58). Women with at least 2 episodes of PID had a 2-fold increased risk of borderline tumors (pOR = 2.14, 95% CI: 1.08, 4.24). No association was observed between PID and ovarian cancer risk overall (pOR = 0.99, 95% CI: 0.83, 1.19); however, a statistically nonsignificantly increased risk of low-grade serous tumors (pOR = 1.48, 95% CI: 0.92, 2.38) was noted. In conclusion, PID was associated with an increased risk of borderline ovarian tumors, particularly among women who had had multiple episodes of PID. Although our results indicated a histotype-specific association with PID, the association of PID with ovarian cancer risk is still somewhat uncertain and requires further investigation.

Published
2017

5. Risk Prediction for Epithelial Ovarian Cancer in 11 United States–Based Case-Control Studies: Incorporation of Epidemiologic Risk Factors and 17 Confirmed Genetic Loci

Author

Clyde, Merlise A, Weber, Rachel Palmieri, Iversen, Edwin S, Poole, Elizabeth M, Doherty, Jennifer A, Goodman, Marc T, Ness, Roberta B, Risch, Harvey A, Rossing, Mary Anne, Terry, Kathryn L, Wentzensen, Nicolas, Whittemore, Alice S, Anton-Culver, Hoda, Bandera, Elisa V, Berchuck, Andrew, Carney, Michael E, Cramer, Daniel W, Cunningham, Julie M, Cushing-Haugen, Kara L, Edwards, Robert P, Fridley, Brooke L, Goode, Ellen L, Lurie, Galina, McGuire, Valerie, Modugno, Francesmary, Moysich, Kirsten B, Olson, Sara H, Pearce, Celeste Leigh, Pike, Malcolm C, Rothstein, Joseph H, Sellers, Thomas A, Sieh, Weiva, Stram, Daniel, Thompson, Pamela J, Vierkant, Robert A, Wicklund, Kristine G, Wu, Anna H, Ziogas, Argyrios, Tworoger, Shelley S, and Schildkraut, Joellen M

Subjects
Epidemiology, Health Sciences, Ovarian Cancer, Rare Diseases, Prevention, Cancer, Adult, Aged, Area Under Curve, Carcinoma, Ovarian Epithelial, Case-Control Studies, Female, Genetic Loci, Genetic Predisposition to Disease, Humans, Logistic Models, Middle Aged, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Polymorphism, Single Nucleotide, Risk Assessment, Risk Factors, United States, genetic risk polymorphisms, model evaluation, ovarian cancer, risk model, on behalf of the Ovarian Cancer Association Consortium, Mathematical Sciences, Medical and Health Sciences
Abstract

Previously developed models for predicting absolute risk of invasive epithelial ovarian cancer have included a limited number of risk factors and have had low discriminatory power (area under the receiver operating characteristic curve (AUC) < 0.60). Because of this, we developed and internally validated a relative risk prediction model that incorporates 17 established epidemiologic risk factors and 17 genome-wide significant single nucleotide polymorphisms (SNPs) using data from 11 case-control studies in the United States (5,793 cases; 9,512 controls) from the Ovarian Cancer Association Consortium (data accrued from 1992 to 2010). We developed a hierarchical logistic regression model for predicting case-control status that included imputation of missing data. We randomly divided the data into an 80% training sample and used the remaining 20% for model evaluation. The AUC for the full model was 0.664. A reduced model without SNPs performed similarly (AUC = 0.649). Both models performed better than a baseline model that included age and study site only (AUC = 0.563). The best predictive power was obtained in the full model among women younger than 50 years of age (AUC = 0.714); however, the addition of SNPs increased the AUC the most for women older than 50 years of age (AUC = 0.638 vs. 0.616). Adapting this improved model to estimate absolute risk and evaluating it in prospective data sets is warranted.

Published
2016

6. The association between socioeconomic status and tumour stage at diagnosis of ovarian cancer: A pooled analysis of 18 case-control studies

Author

Præstegaard, Camilla, Kjaer, Susanne K, Nielsen, Thor SS, Jensen, Signe M, Webb, Penelope M, Nagle, Christina M, Høgdall, Estrid, Risch, Harvey A, Rossing, Mary Anne, Doherty, Jennifer A, Wicklund, Kristine G, Goodman, Marc T, Modugno, Francesmary, Moysich, Kirsten, Ness, Roberta B, Edwards, Robert P, Goode, Ellen L, Winham, Stacey J, Fridley, Brooke L, Cramer, Daniel W, Terry, Kathryn L, Schildkraut, Joellen M, Berchuck, Andrew, Bandera, Elisa V, Paddock, Lisa, Kiemeney, Lambertus A, Massuger, Leon F, Wentzensen, Nicolas, Pharoah, Paul, Song, Honglin, Whittemore, Alice S, McGuire, Valerie, Sieh, Weiva, Rothstein, Joseph, Anton-Culver, Hoda, Ziogas, Argyrios, Menon, Usha, Gayther, Simon A, Ramus, Susan J, Gentry-Maharaj, Aleksandra, Wu, Anna H, Pearce, Celeste L, Pike, Malcolm C, Lee, Alice W, Chang-Claude, Jenny, Jensen, Allan, and Consortium, Ovarian Cancer Association

Subjects
Biomedical and Clinical Sciences, Epidemiology, Health Services and Systems, Health Sciences, Oncology and Carcinogenesis, Cancer, Ovarian Cancer, Tobacco Smoke and Health, Rare Diseases, Tobacco, Prevention, Aged, Carcinoma, Ovarian Epithelial, Case-Control Studies, Delayed Diagnosis, Female, Humans, Logistic Models, Middle Aged, Neoplasms, Glandular and Epithelial, Odds Ratio, Ovarian Neoplasms, Social Class, Ovarian cancer, Pooled analysis, Socioeconomic status, Tumour stage, Ovarian Cancer Association Consortium, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

PurposeSocioeconomic status (SES) is a known predictor of survival for several cancers and it has been suggested that SES differences affecting tumour stage at diagnosis may be the most important explanatory factor for this. However, only a limited number of studies have investigated SES differences in tumour stage at diagnosis of ovarian cancer. In a pooled analysis, we investigated whether SES as represented by level of education is predictive for advanced tumour stage at diagnosis of ovarian cancer, overall and by histotype. The effect of cigarette smoking and body mass index (BMI) on the association was also evaluated.MethodsFrom 18 case-control studies, we obtained information on 10,601 women diagnosed with epithelial ovarian cancer. Study specific odds ratios (ORs) with corresponding 95% confidence intervals (CI) were obtained from logistic regression models and combined into a pooled odds ratio (pOR) using a random effects model.ResultsOverall, women who completed ≤high school had an increased risk of advanced tumour stage at diagnosis compared with women who completed >high school (pOR 1.15; 95% CI 1.03-1.28). The risk estimates for the different histotypes of ovarian cancer resembled that observed for ovarian cancers combined but did not reach statistical significance. Our results were unchanged when we included BMI and cigarette smoking.ConclusionLower level of education was associated with an increased risk of advanced tumour stage at diagnosis of ovarian cancer. The observed socioeconomic difference in stage at diagnosis of ovarian cancer calls for further studies on how to reduce this diagnostic delay.

Published
2016

7. Evidence of a genetic link between endometriosis and ovarian cancer

Author

Lee, Alice W, Templeman, Claire, Stram, Douglas A, Beesley, Jonathan, Tyrer, Jonathan, Berchuck, Andrew, Pharoah, Paul P, Chenevix-Trench, Georgia, Pearce, Celeste Leigh, Consortium, Ovarian Cancer Association, Ness, Roberta B, Dansonka-Mieszkowska, Agnieszka, Gentry-Maharaj, Aleksandra, Hein, Alexander, Whittemore, Alice S, Jensen, Allan, du Bois, Andreas, Brooks-Wilson, Angela, Rudolph, Anja, Jakubowska, Anna, Wu, Anna H, Ziogas, Argyrios, Ekici, Arif B, Leminen, Arto, Study, Australian Cancer, Group, Australian Ovarian Cancer Study, Rosen, Barry, Spiewankiewicz, Beata, Karlan, Beth Y, Trabert, Britton, Fridley, Brooke L, Gilks, C Blake, Krakstad, Camilla, Phelan, Catherine M, Cybulski, Cezary, Walsh, Christine, Hogdall, Claus, Cramer, Daniel W, Huntsman, David G, Eccles, Diana, Lambrechts, Diether, Liang, Dong, Levine, Douglas A, Iversen, Edwin S, Bandera, Elisa V, Poole, Elizabeth M, Goode, Ellen L, Van Nieuwenhuysen, Els, Hogdall, Estrid, Bruinsma, Fiona, Heitz, Florian, Modugno, Francesmary, Giles, Graham G, Risch, Harvey A, Baker, Helen, Salvesen, Helga B, Nevanlinna, Heli, Anton-Culver, Hoda, Song, Honglin, McNeish, Iain, Campbell, Ian G, Vergote, Ignace, Runnebaum, Ingo B, Tangen, Ingvild L, Schwaab, Ira, Gronwald, Jacek, Paul, James, Lubinski, Jan, Doherty, Jennifer A, Chang-Claude, Jenny, Lester, Jenny, Schildkraut, Joellen M, McLaughlin, John R, Lissowska, Jolanta, Kupryjanczyk, Jolanta, Kelley, Joseph L, Rothstein, Joseph H, Cunningham, Julie M, Lu, Karen, Carty, Karen, Terry, Kathryn L, Aben, Katja KH, Moysich, Kirsten B, Wicklund, Kristine G, Odunsi, Kunle, Kiemeney, Lambertus A, Sucheston-Campbell, Lara, Lundvall, Lene, Massuger, Leon FAG, Pelttari, Liisa M, Kelemen, Linda E, Cook, Linda S, Bjorge, Line, Nedergaard, Lotte, Brinton, Louise A, Wilkens, Lynne R, Pike, Malcolm C, Goodman, Marc T, and Bisogna, Maria

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Prevention, Cancer, Rare Diseases, Ovarian Cancer, Genetics, Genetic Testing, Clinical Research, Endometriosis, 2.1 Biological and endogenous factors, Aetiology, Case-Control Studies, Computational Biology, Databases, Genetic, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Neoplasm Grading, Ovarian Neoplasms, Phenotype, Polymorphism, Single Nucleotide, Risk Assessment, Risk Factors, Ovarian Cancer Association Consortium, SNPs, genetic variation, ovarian cancer, Clinical Sciences, Paediatrics and Reproductive Medicine, Public Health and Health Services, Obstetrics & Reproductive Medicine, Reproductive medicine
Abstract

ObjectiveTo evaluate whether endometriosis-associated genetic variation affects risk of ovarian cancer.DesignPooled genetic analysis.SettingUniversity hospital.Patient(s)Genetic data from 46,176 participants (15,361 ovarian cancer cases and 30,815 controls) from 41 ovarian cancer studies.Intervention(s)None.Main outcome measure(s)Endometriosis-associated genetic variation and ovarian cancer.Result(s)There was significant evidence of an association between endometriosis-related genetic variation and ovarian cancer risk, especially for the high-grade serous and clear cell histotypes. Overall we observed 15 significant burden statistics, which was three times more than expected.Conclusion(s)By focusing on candidate regions from a phenotype associated with ovarian cancer, we have shown a clear genetic link between endometriosis and ovarian cancer that warrants further follow-up. The functional significance of the identified regions and SNPs is presently uncertain, though future fine mapping and histotype-specific functional analyses may shed light on the etiologies of both gynecologic conditions.

Published
2016

8. Evaluating the ovarian cancer gonadotropin hypothesis: a candidate gene study.

Author

Lee, Alice W, Tyrer, Jonathan P, Doherty, Jennifer A, Stram, Douglas A, Kupryjanczyk, Jolanta, Dansonka-Mieszkowska, Agnieszka, Plisiecka-Halasa, Joanna, Spiewankiewicz, Beata, Myers, Emily J, Australian Cancer Study (Ovarian Cancer), Australian Ovarian Cancer Study Group, Chenevix-Trench, Georgia, Fasching, Peter A, Beckmann, Matthias W, Ekici, Arif B, Hein, Alexander, Vergote, Ignace, Van Nieuwenhuysen, Els, Lambrechts, Diether, Wicklund, Kristine G, Eilber, Ursula, Wang-Gohrke, Shan, Chang-Claude, Jenny, Rudolph, Anja, Sucheston-Campbell, Lara, Odunsi, Kunle, Moysich, Kirsten B, Shvetsov, Yurii B, Thompson, Pamela J, Goodman, Marc T, Wilkens, Lynne R, Dörk, Thilo, Hillemanns, Peter, Dürst, Matthias, Runnebaum, Ingo B, Bogdanova, Natalia, Pelttari, Liisa M, Nevanlinna, Heli, Leminen, Arto, Edwards, Robert P, Kelley, Joseph L, Harter, Philipp, Schwaab, Ira, Heitz, Florian, du Bois, Andreas, Orsulic, Sandra, Lester, Jenny, Walsh, Christine, Karlan, Beth Y, Hogdall, Estrid, Kjaer, Susanne K, Jensen, Allan, Vierkant, Robert A, Cunningham, Julie M, Goode, Ellen L, Fridley, Brooke L, Southey, Melissa C, Giles, Graham G, Bruinsma, Fiona, Wu, Xifeng, Hildebrandt, Michelle AT, Lu, Karen, Liang, Dong, Bisogna, Maria, Levine, Douglas A, Weber, Rachel Palmieri, Schildkraut, Joellen M, Iversen, Edwin S, Berchuck, Andrew, Terry, Kathryn L, Cramer, Daniel W, Tworoger, Shelley S, Poole, Elizabeth M, Olson, Sara H, Orlow, Irene, Bandera, Elisa V, Bjorge, Line, Tangen, Ingvild L, Salvesen, Helga B, Krakstad, Camilla, Massuger, Leon FAG, Kiemeney, Lambertus A, Aben, Katja KH, van Altena, Anne M, Bean, Yukie, Pejovic, Tanja, Kellar, Melissa, Le, Nhu D, Cook, Linda S, Kelemen, Linda E, Brooks-Wilson, Angela, Lubinski, Jan, Gronwald, Jacek, Cybulski, Cezary, Jakubowska, Anna, Wentzensen, Nicolas, Brinton, Louise A, Lissowska, Jolanta, Yang, Hannah, and Nedergaard, Lotte

Subjects
Australian Cancer Study, Australian Ovarian Cancer Study Group, Humans, Ovarian Neoplasms, Genetic Predisposition to Disease, Gonadotropins, Genetic Markers, Logistic Models, Risk Factors, Case-Control Studies, Signal Transduction, Genotype, Polymorphism, Single Nucleotide, Female, Genome-Wide Association Study, Biomarkers, Tumor, Gene, Genetic variation, Genetics, Ovarian cancer, Polymorphisms, Polymorphism, Single Nucleotide, Biomarkers, Tumor, Ovarian Cancer, Aging, Prevention, Human Genome, Cancer, Biotechnology, Rare Diseases, 2.1 Biological and endogenous factors, Oncology & Carcinogenesis, Oncology and Carcinogenesis, Paediatrics and Reproductive Medicine
Abstract

ObjectiveOvarian cancer is a hormone-related disease with a strong genetic basis. However, none of its high-penetrance susceptibility genes and GWAS-identified variants to date are known to be involved in hormonal pathways. Given the hypothesized etiologic role of gonadotropins, an assessment of how variability in genes involved in the gonadotropin signaling pathway impacts disease risk is warranted.MethodsGenetic data from 41 ovarian cancer study sites were pooled and unconditional logistic regression was used to evaluate whether any of the 2185 SNPs from 11 gonadotropin signaling pathway genes was associated with ovarian cancer risk. A burden test using the admixture likelihood (AML) method was also used to evaluate gene-level associations.ResultsWe did not find any genome-wide significant associations between individual SNPs and ovarian cancer risk. However, there was some suggestion of gene-level associations for four gonadotropin signaling pathway genes: INHBB (p=0.045, mucinous), LHCGR (p=0.046, high-grade serous), GNRH (p=0.041, high-grade serous), and FSHB (p=0.036, overall invasive). There was also suggestive evidence for INHA (p=0.060, overall invasive).ConclusionsOvarian cancer studies have limited sample numbers, thus fewer genome-wide susceptibility alleles, with only modest associations, have been identified relative to breast and prostate cancers. We have evaluated the majority of ovarian cancer studies with biological samples, to our knowledge, leaving no opportunity for replication. Using both our understanding of biology and powerful gene-level tests, we have identified four putative ovarian cancer loci near INHBB, LHCGR, GNRH, and FSHB that warrant a second look if larger sample sizes and denser genotype chips become available.

Published
2015

9. Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies.

Author

Pearce, Celeste Leigh, Templeman, Claire, Rossing, Mary Anne, Lee, Alice, Near, Aimee M, Webb, Penelope M, Nagle, Christina M, Doherty, Jennifer A, Cushing-Haugen, Kara L, Wicklund, Kristine G, Chang-Claude, Jenny, Hein, Rebecca, Lurie, Galina, Wilkens, Lynne R, Carney, Michael E, Goodman, Marc T, Moysich, Kirsten, Kjaer, Susanne K, Hogdall, Estrid, Jensen, Allan, Goode, Ellen L, Fridley, Brooke L, Larson, Melissa C, Schildkraut, Joellen M, Palmieri, Rachel T, Cramer, Daniel W, Terry, Kathryn L, Vitonis, Allison F, Titus, Linda J, Ziogas, Argyrios, Brewster, Wendy, Anton-Culver, Hoda, Gentry-Maharaj, Alexandra, Ramus, Susan J, Anderson, A Rebecca, Brueggmann, Doerthe, Fasching, Peter A, Gayther, Simon A, Huntsman, David G, Menon, Usha, Ness, Roberta B, Pike, Malcolm C, Risch, Harvey, Wu, Anna H, Berchuck, Andrew, and Ovarian Cancer Association Consortium

Subjects
Ovarian Cancer Association Consortium, Humans, Ovarian Neoplasms, Neoplasm Invasiveness, Endometriosis, Neoplasm Staging, Risk Factors, Case-Control Studies, Aged, Aged, 80 and over, Middle Aged, Ethnic Groups, Female, Cancer, Ovarian Cancer, Rare Diseases, Oncology & Carcinogenesis, Oncology and Carcinogenesis
Abstract

BackgroundEndometriosis is a risk factor for epithelial ovarian cancer; however, whether this risk extends to all invasive histological subtypes or borderline tumours is not clear. We undertook an international collaborative study to assess the association between endometriosis and histological subtypes of ovarian cancer.MethodsData from 13 ovarian cancer case-control studies, which were part of the Ovarian Cancer Association Consortium, were pooled and logistic regression analyses were undertaken to assess the association between self-reported endometriosis and risk of ovarian cancer. Analyses of invasive cases were done with respect to histological subtypes, grade, and stage, and analyses of borderline tumours by histological subtype. Age, ethnic origin, study site, parity, and duration of oral contraceptive use were included in all analytical models.Findings13 226 controls and 7911 women with invasive ovarian cancer were included in this analysis. 818 and 738, respectively, reported a history of endometriosis. 1907 women with borderline ovarian cancer were also included in the analysis, and 168 of these reported a history of endometriosis. Self-reported endometriosis was associated with a significantly increased risk of clear-cell (136 [20·2%] of 674 cases vs 818 [6·2%] of 13 226 controls, odds ratio 3·05, 95% CI 2·43-3·84, p

Published
2012

13. Supplemental Tables S1-S4 from Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium

Author

Cannioto, Rikki, primary, LaMonte, Michael J., primary, Risch, Harvey A., primary, Hong, Chi-Chen, primary, Sucheston-Campbell, Lara E., primary, Eng, Kevin H., primary, Brian Szender, J., primary, Chang-Claude, Jenny, primary, Schmalfeldt, Barbara, primary, Klapdor, Ruediger, primary, Gower, Emily, primary, Minlikeeva, Albina N., primary, Zirpoli, Gary R., primary, Bandera, Elisa V., primary, Berchuck, Andrew, primary, Cramer, Daniel, primary, Doherty, Jennifer A., primary, Edwards, Robert P., primary, Fridley, Brooke L., primary, Goode, Ellen L., primary, Goodman, Marc T., primary, Hogdall, Estrid, primary, Hosono, Satoyo, primary, Jensen, Allan, primary, Jordan, Susan, primary, Kjaer, Susanne K., primary, Matsuo, Keitaro, primary, Ness, Roberta B., primary, Olsen, Catherine M., primary, Olson, Sara H., primary, Leigh Pearce, Celeste, primary, Pike, Malcolm C., primary, Anne Rossing, Mary, primary, Szamreta, Elizabeth A., primary, Thompson, Pamela J., primary, Tseng, Chiu-Chen, primary, Vierkant, Robert A., primary, Webb, Penelope M., primary, Wentzensen, Nicolas, primary, Wicklund, Kristine G., primary, Winham, Stacey J., primary, Wu, Anna H., primary, Modugno, Francesmary, primary, Schildkraut, Joellen M., primary, Terry, Kathryn L., primary, Kelemen, Linda E., primary, and Moysich, Kirsten B., primary

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2023
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14. Data from Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium

Author

Cannioto, Rikki, primary, LaMonte, Michael J., primary, Risch, Harvey A., primary, Hong, Chi-Chen, primary, Sucheston-Campbell, Lara E., primary, Eng, Kevin H., primary, Brian Szender, J., primary, Chang-Claude, Jenny, primary, Schmalfeldt, Barbara, primary, Klapdor, Ruediger, primary, Gower, Emily, primary, Minlikeeva, Albina N., primary, Zirpoli, Gary R., primary, Bandera, Elisa V., primary, Berchuck, Andrew, primary, Cramer, Daniel, primary, Doherty, Jennifer A., primary, Edwards, Robert P., primary, Fridley, Brooke L., primary, Goode, Ellen L., primary, Goodman, Marc T., primary, Hogdall, Estrid, primary, Hosono, Satoyo, primary, Jensen, Allan, primary, Jordan, Susan, primary, Kjaer, Susanne K., primary, Matsuo, Keitaro, primary, Ness, Roberta B., primary, Olsen, Catherine M., primary, Olson, Sara H., primary, Leigh Pearce, Celeste, primary, Pike, Malcolm C., primary, Anne Rossing, Mary, primary, Szamreta, Elizabeth A., primary, Thompson, Pamela J., primary, Tseng, Chiu-Chen, primary, Vierkant, Robert A., primary, Webb, Penelope M., primary, Wentzensen, Nicolas, primary, Wicklund, Kristine G., primary, Winham, Stacey J., primary, Wu, Anna H., primary, Modugno, Francesmary, primary, Schildkraut, Joellen M., primary, Terry, Kathryn L., primary, Kelemen, Linda E., primary, and Moysich, Kirsten B., primary

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2023
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15. Data from Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk

Author

Kar, Siddhartha P., primary, Tyrer, Jonathan P., primary, Li, Qiyuan, primary, Lawrenson, Kate, primary, Aben, Katja K.H., primary, Anton-Culver, Hoda, primary, Antonenkova, Natalia, primary, Chenevix-Trench, Georgia, primary, Baker, Helen, primary, Bandera, Elisa V., primary, Bean, Yukie T., primary, Beckmann, Matthias W., primary, Berchuck, Andrew, primary, Bisogna, Maria, primary, Bjørge, Line, primary, Bogdanova, Natalia, primary, Brinton, Louise, primary, Brooks-Wilson, Angela, primary, Butzow, Ralf, primary, Campbell, Ian, primary, Carty, Karen, primary, Chang-Claude, Jenny, primary, Chen, Yian Ann, primary, Chen, Zhihua, primary, Cook, Linda S., primary, Cramer, Daniel, primary, Cunningham, Julie M., primary, Cybulski, Cezary, primary, Dansonka-Mieszkowska, Agnieszka, primary, Dennis, Joe, primary, Dicks, Ed, primary, Doherty, Jennifer A., primary, Dörk, Thilo, primary, du Bois, Andreas, primary, Dürst, Matthias, primary, Eccles, Diana, primary, Easton, Douglas F., primary, Edwards, Robert P., primary, Ekici, Arif B., primary, Fasching, Peter A., primary, Fridley, Brooke L., primary, Gao, Yu-Tang, primary, Gentry-Maharaj, Aleksandra, primary, Giles, Graham G., primary, Glasspool, Rosalind, primary, Goode, Ellen L., primary, Goodman, Marc T., primary, Grownwald, Jacek, primary, Harrington, Patricia, primary, Harter, Philipp, primary, Hein, Alexander, primary, Heitz, Florian, primary, Hildebrandt, Michelle A.T., primary, Hillemanns, Peter, primary, Hogdall, Estrid, primary, Hogdall, Claus K., primary, Hosono, Satoyo, primary, Iversen, Edwin S., primary, Jakubowska, Anna, primary, Paul, James, primary, Jensen, Allan, primary, Ji, Bu-Tian, primary, Karlan, Beth Y., primary, Kjaer, Susanne K., primary, Kelemen, Linda E., primary, Kellar, Melissa, primary, Kelley, Joseph, primary, Kiemeney, Lambertus A., primary, Krakstad, Camilla, primary, Kupryjanczyk, Jolanta, primary, Lambrechts, Diether, primary, Lambrechts, Sandrina, primary, Le, Nhu D., primary, Lee, Alice W., primary, Lele, Shashi, primary, Leminen, Arto, primary, Lester, Jenny, primary, Levine, Douglas A., primary, Liang, Dong, primary, Lissowska, Jolanta, primary, Lu, Karen, primary, Lubinski, Jan, primary, Lundvall, Lene, primary, Massuger, Leon, primary, Matsuo, Keitaro, primary, McGuire, Valerie, primary, McLaughlin, John R., primary, McNeish, Iain A., primary, Menon, Usha, primary, Modugno, Francesmary, primary, Moysich, Kirsten B., primary, Narod, Steven A., primary, Nedergaard, Lotte, primary, Ness, Roberta B., primary, Nevanlinna, Heli, primary, Odunsi, Kunle, primary, Olson, Sara H., primary, Orlow, Irene, primary, Orsulic, Sandra, primary, Weber, Rachel Palmieri, primary, Pearce, Celeste Leigh, primary, Pejovic, Tanja, primary, Pelttari, Liisa M., primary, Permuth-Wey, Jennifer, primary, Phelan, Catherine M., primary, Pike, Malcolm C., primary, Poole, Elizabeth M., primary, Ramus, Susan J., primary, Risch, Harvey A., primary, Rosen, Barry, primary, Rossing, Mary Anne, primary, Rothstein, Joseph H., primary, Rudolph, Anja, primary, Runnebaum, Ingo B., primary, Rzepecka, Iwona K., primary, Salvesen, Helga B., primary, Schildkraut, Joellen M., primary, Schwaab, Ira, primary, Shu, Xiao-Ou, primary, Shvetsov, Yurii B., primary, Siddiqui, Nadeem, primary, Sieh, Weiva, primary, Song, Honglin, primary, Southey, Melissa C., primary, Sucheston-Campbell, Lara E., primary, Tangen, Ingvild L., primary, Teo, Soo-Hwang, primary, Terry, Kathryn L., primary, Thompson, Pamela J., primary, Timorek, Agnieszka, primary, Tsai, Ya-Yu, primary, Tworoger, Shelley S., primary, van Altena, Anne M., primary, Van Nieuwenhuysen, Els, primary, Vergote, Ignace, primary, Vierkant, Robert A., primary, Wang-Gohrke, Shan, primary, Walsh, Christine, primary, Wentzensen, Nicolas, primary, Whittemore, Alice S., primary, Wicklund, Kristine G., primary, Wilkens, Lynne R., primary, Woo, Yin-Ling, primary, Wu, Xifeng, primary, Wu, Anna, primary, Yang, Hannah, primary, Zheng, Wei, primary, Ziogas, Argyrios, primary, Sellers, Thomas A., primary, Monteiro, Alvaro N.A., primary, Freedman, Matthew L., primary, Gayther, Simon A., primary, and Pharoah, Paul D.P., primary

Published
2023
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16. Supplementary Tables S1-6, Figures S1-2 from Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk

Author

Kar, Siddhartha P., primary, Tyrer, Jonathan P., primary, Li, Qiyuan, primary, Lawrenson, Kate, primary, Aben, Katja K.H., primary, Anton-Culver, Hoda, primary, Antonenkova, Natalia, primary, Chenevix-Trench, Georgia, primary, Baker, Helen, primary, Bandera, Elisa V., primary, Bean, Yukie T., primary, Beckmann, Matthias W., primary, Berchuck, Andrew, primary, Bisogna, Maria, primary, Bjørge, Line, primary, Bogdanova, Natalia, primary, Brinton, Louise, primary, Brooks-Wilson, Angela, primary, Butzow, Ralf, primary, Campbell, Ian, primary, Carty, Karen, primary, Chang-Claude, Jenny, primary, Chen, Yian Ann, primary, Chen, Zhihua, primary, Cook, Linda S., primary, Cramer, Daniel, primary, Cunningham, Julie M., primary, Cybulski, Cezary, primary, Dansonka-Mieszkowska, Agnieszka, primary, Dennis, Joe, primary, Dicks, Ed, primary, Doherty, Jennifer A., primary, Dörk, Thilo, primary, du Bois, Andreas, primary, Dürst, Matthias, primary, Eccles, Diana, primary, Easton, Douglas F., primary, Edwards, Robert P., primary, Ekici, Arif B., primary, Fasching, Peter A., primary, Fridley, Brooke L., primary, Gao, Yu-Tang, primary, Gentry-Maharaj, Aleksandra, primary, Giles, Graham G., primary, Glasspool, Rosalind, primary, Goode, Ellen L., primary, Goodman, Marc T., primary, Grownwald, Jacek, primary, Harrington, Patricia, primary, Harter, Philipp, primary, Hein, Alexander, primary, Heitz, Florian, primary, Hildebrandt, Michelle A.T., primary, Hillemanns, Peter, primary, Hogdall, Estrid, primary, Hogdall, Claus K., primary, Hosono, Satoyo, primary, Iversen, Edwin S., primary, Jakubowska, Anna, primary, Paul, James, primary, Jensen, Allan, primary, Ji, Bu-Tian, primary, Karlan, Beth Y., primary, Kjaer, Susanne K., primary, Kelemen, Linda E., primary, Kellar, Melissa, primary, Kelley, Joseph, primary, Kiemeney, Lambertus A., primary, Krakstad, Camilla, primary, Kupryjanczyk, Jolanta, primary, Lambrechts, Diether, primary, Lambrechts, Sandrina, primary, Le, Nhu D., primary, Lee, Alice W., primary, Lele, Shashi, primary, Leminen, Arto, primary, Lester, Jenny, primary, Levine, Douglas A., primary, Liang, Dong, primary, Lissowska, Jolanta, primary, Lu, Karen, primary, Lubinski, Jan, primary, Lundvall, Lene, primary, Massuger, Leon, primary, Matsuo, Keitaro, primary, McGuire, Valerie, primary, McLaughlin, John R., primary, McNeish, Iain A., primary, Menon, Usha, primary, Modugno, Francesmary, primary, Moysich, Kirsten B., primary, Narod, Steven A., primary, Nedergaard, Lotte, primary, Ness, Roberta B., primary, Nevanlinna, Heli, primary, Odunsi, Kunle, primary, Olson, Sara H., primary, Orlow, Irene, primary, Orsulic, Sandra, primary, Weber, Rachel Palmieri, primary, Pearce, Celeste Leigh, primary, Pejovic, Tanja, primary, Pelttari, Liisa M., primary, Permuth-Wey, Jennifer, primary, Phelan, Catherine M., primary, Pike, Malcolm C., primary, Poole, Elizabeth M., primary, Ramus, Susan J., primary, Risch, Harvey A., primary, Rosen, Barry, primary, Rossing, Mary Anne, primary, Rothstein, Joseph H., primary, Rudolph, Anja, primary, Runnebaum, Ingo B., primary, Rzepecka, Iwona K., primary, Salvesen, Helga B., primary, Schildkraut, Joellen M., primary, Schwaab, Ira, primary, Shu, Xiao-Ou, primary, Shvetsov, Yurii B., primary, Siddiqui, Nadeem, primary, Sieh, Weiva, primary, Song, Honglin, primary, Southey, Melissa C., primary, Sucheston-Campbell, Lara E., primary, Tangen, Ingvild L., primary, Teo, Soo-Hwang, primary, Terry, Kathryn L., primary, Thompson, Pamela J., primary, Timorek, Agnieszka, primary, Tsai, Ya-Yu, primary, Tworoger, Shelley S., primary, van Altena, Anne M., primary, Van Nieuwenhuysen, Els, primary, Vergote, Ignace, primary, Vierkant, Robert A., primary, Wang-Gohrke, Shan, primary, Walsh, Christine, primary, Wentzensen, Nicolas, primary, Whittemore, Alice S., primary, Wicklund, Kristine G., primary, Wilkens, Lynne R., primary, Woo, Yin-Ling, primary, Wu, Xifeng, primary, Wu, Anna, primary, Yang, Hannah, primary, Zheng, Wei, primary, Ziogas, Argyrios, primary, Sellers, Thomas A., primary, Monteiro, Alvaro N.A., primary, Freedman, Matthew L., primary, Gayther, Simon A., primary, and Pharoah, Paul D.P., primary

Published
2023
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24. Association Between Menopausal Estrogen-Only Therapy and Ovarian Carcinoma Risk

Author

Lee, Alice W., Ness, Roberta B., Roman, Lynda D., Terry, Kathryn L., Schildkraut, Joellen M., Chang-Claude, Jenny, Doherty, Jennifer A., Menon, Usha, Cramer, Daniel W., Gayther, Simon A., Risch, Harvey, Gentry-Maharaj, Aleksandra, Goodman, Marc T., Modugno, Francesmary, Eilber, Ursula, Moysich, Kirsten B., Berchuck, Andrew, Rossing, Mary Anne, Jensen, Allan, Wicklund, Kristine G., Cushing-Haugen, Kara L., Hogdall, Estrid, Rudolph, Anja, Thompson, Pamela J., Wilkens, Lynne R., Kjaer, Susanne K., Carney, Michael E., Stram, Daniel O., Ramus, Susan J., Wu, Anna H., Pike, Malcolm C., and Pearce, Celeste Leigh

Published
2016
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25. Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer

Author

Lawrenson, Kate, Iversen, Edwin S., Tyrer, Jonathan, Weber, Rachel Palmieri, Concannon, Patrick, Hazelett, Dennis J., Li, Qiyuan, Marks, Jeffrey R., Berchuck, Andrew, Lee, Janet M., Aben, Katja K.H., Anton-Culver, Hoda, Antonenkova, Natalia, Bandera, Elisa V., Bean, Yukie, Beckmann, Matthias W., Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A., Brooks-Wilson, Angela, Bruinsma, Fiona, Butzow, Ralf, Campbell, Ian G., Carty, Karen, Chang-Claude, Jenny, Chenevix-Trench, Georgia, Chen, Ann, Chen, Zhihua, Cook, Linda S., Cramer, Daniel W., Cunningham, Julie M., Cybulski, Cezary, Plisiecka-Halasa, Joanna, Dennis, Joe, Dicks, Ed, Doherty, Jennifer A., Dörk, Thilo, du Bois, Andreas, Eccles, Diana, Easton, Douglas T., Edwards, Robert P., Eilber, Ursula, Ekici, Arif B., Fasching, Peter A., Fridley, Brooke L., Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G., Glasspool, Rosalind, Goode, Ellen L., Goodman, Marc T., Gronwald, Jacek, Harter, Philipp, Hasmad, Hanis Nazihah, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle A.T., Hillemanns, Peter, Hogdall, Estrid, Hogdall, Claus, Hosono, Satoyo, Jakubowska, Anna, Paul, James, Jensen, Allan, Karlan, Beth Y., Kjaer, Susanne Kruger, Kelemen, Linda E., Kellar, Melissa, Kelley, Joseph L., Kiemeney, Lambertus A., Krakstad, Camilla, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D., Lee, Alice W., Cannioto, Rikki, Leminen, Arto, Lester, Jenny, Levine, Douglas A., Liang, Dong, Lissowska, Jolanta, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon F.A.G., Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John R., Nevanlinna, Heli, McNeish, Iain, Menon, Usha, Modugno, Francesmary, Moysich, Kirsten B., Narod, Steven A., Nedergaard, Lotte, Ness, Roberta B., Noor Azmi, Mat Adenan, Odunsi, Kunle, Olson, Sara H., Orlow, Irene, Orsulic, Sandra, Pearce, Celeste L., Pejovic, Tanja, Pelttari, Liisa M., Permuth-Wey, Jennifer, Phelan, Catherine M., Pike, Malcolm C., Poole, Elizabeth M., Ramus, Susan J., Risch, Harvey A., Rosen, Barry, Rossing, Mary Anne, Rothstein, Joseph H., Rudolph, Anja, Runnebaum, Ingo B., Rzepecka, Iwona K., Salvesen, Helga B., Budzilowska, Agnieszka, Sellers, Thomas A., Shu, Xiao-Ou, Shvetsov, Yurii B., Siddiqui, Nadeem, Sieh, Weiva, Song, Honglin, Southey, Melissa C., Sucheston, Lara, Tangen, Ingvild L., Teo, Soo-Hwang, Terry, Kathryn L., Thompson, Pamela J., Timorek, Agnieszka, Tworoger, Shelley S., Nieuwenhuysen, Els Van, Vergote, Ignace, Vierkant, Robert A., Wang-Gohrke, Shan, Walsh, Christine, Wentzensen, Nicolas, Whittemore, Alice S., Wicklund, Kristine G., Wilkens, Lynne R., Woo, Yin-Ling, Wu, Xifeng, Wu, Anna H., Yang, Hannah, Zheng, Wei, Ziogas, Argyrios, Coetzee, Gerhard A., Freedman, Matthew L., Monteiro, Alvaro N.A., Moes-Sosnowska, Joanna, Kupryjanczyk, Jolanta, Pharoah, Paul D., Gayther, Simon A., and Schildkraut, Joellen M.

Published
2015
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26. Shared genetics underlying epidemiological association between endometriosis and ovarian cancer

Author

Lu, Yi, Cuellar-Partida, Gabriel, Painter, Jodie N., Nyholt, Dale R., Morris, Andrew P., Fasching, Peter A., Hein, Alexander, Burghaus, Stefanie, Beckmann, Matthias W., Lambrechts, Diether, Van Nieuwenhuysen, Els, Vergote, Ignace, Vanderstichele, Adriaan, Doherty, Jennifer Anne, Rossing, Mary Anne, Wicklund, Kristine G., Chang-Claude, Jenny, Eilber, Ursula, Rudolph, Anja, Wang-Gohrke, Shan, Goodman, Marc T., Bogdanova, Natalia, Dörk, Thilo, Dürst, Matthias, Hillemanns, Peter, Runnebaum, Ingo B., Antonenkova, Natalia, Butzow, Ralf, Leminen, Arto, Nevanlinna, Heli, Pelttari, Liisa M., Edwards, Robert P., Kelley, Joseph L., Modugno, Francesmary, Moysich, Kirsten B., Ness, Roberta B., Cannioto, Rikki, Høgdall, Estrid, Jensen, Allan, Giles, Graham G., Bruinsma, Fiona, Kjaer, Susanne K., Hildebrandt, Michelle A.T., Liang, Dong, Lu, Karen H., Wu, Xifeng, Bisogna, Maria, Dao, Fanny, Levine, Douglas A., Cramer, Daniel W., Terry, Kathryn L., Tworoger, Shelley S., Missmer, Stacey, Bjorge, Line, Salvesen, Helga B., Kopperud, Reidun K., Bischof, Katharina, Aben, Katja K.H., Kiemeney, Lambertus A., Massuger, Leon F.A.G., Brooks-Wilson, Angela, Olson, Sara H., McGuire, Valerie, Rothstein, Joseph H., Sieh, Weiva, Whittemore, Alice S., Cook, Linda S., Le, Nhu D., Gilks, C. Blake, Gronwald, Jacek, Jakubowska, Anna, Lubiński, Jan, Gawełko, Jan, Song, Honglin, Tyrer, Jonathan P., Wentzensen, Nicolas, Brinton, Louise, Trabert, Britton, Lissowska, Jolanta, Mclaughlin, John R., Narod, Steven A., Phelan, Catherine, Anton-Culver, Hoda, Ziogas, Argyrios, Eccles, Diana, Gayther, Simon A., Gentry-Maharaj, Aleksandra, Menon, Usha, Ramus, Susan J., Wu, Anna H., Dansonka-Mieszkowska, Agnieszka, Kupryjanczyk, Jolanta, Timorek, Agnieszka, Szafron, Lukasz, Cunningham, Julie M., Fridley, Brooke L., Winham, Stacey J., Bandera, Elisa V., Poole, Elizabeth M., Morgan, Terry K., Risch, Harvey A., Goode, Ellen L., Schildkraut, Joellen M., Webb, Penelope M., Pearce, Celeste L., Berchuck, Andrew, Pharoah, Paul D.P., Montgomery, Grant W., Zondervan, Krina T., Chenevix-Trench, Georgia, MacGregor, Stuart, Anderson, Carl A., Gordon, Scott D., Guo, Qun, Henders, Anjali K., Lambert, Ann, Lee, Sang Hong, Kraft, Peter, Kennedy, Stephen H., Macgregor, Stuart, Martin, Nicholas G., Missmer, Stacey A., Montgomery, Grant W., Morris, Andrew P., Nyholt, Dale R., Painter, Jodie N., Roseman, Fenella, Treloar, Susan A., Visscher, Peter M., Wallace, Leanne, and Zondervan, Krina T.

Published
2015
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27. Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci

Author

Coetzee, Simon G., Shen, Howard C., Hazelett, Dennis J., Lawrenson, Kate, Kuchenbaecker, Karoline, Tyrer, Jonathan, Rhie, Suhn K., Levanon, Keren, Karst, Alison, Drapkin, Ronny, Ramus, Susan J., Couch, Fergus J., Offit, Kenneth, Chenevix-Trench, Georgia, Monteiro, Alvaro N.A., Antoniou, Antonis, Freedman, Matthew, Coetzee, Gerhard A., Pharoah, Paul D.P., Noushmehr, Houtan, Gayther, Simon A., Tyrer, Jonathan, Anton-Culver, Hoda, Antonenkova, Natalia, Baker, Helen, Bandera, Elisa V., Bean, Yukie, Beckmann, Matthias W., Berchuck, Andrew, Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A., Brooks-Wilson, Angela, Bruinsma, Fiona, Butzow, Ralf, Campbell, Ian G., Carty, Karen, Chang-Claude, Jenny, Chen, Ann, Chen, Zhihua, Cook, Linda S., Cramer, Daniel W., Cunningham, Julie M., Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, Dennis, Joe, Dicks, Ed, Doherty, Jennifer A., Dörk, Thilo, Bois, Andreas du, Dürst, Matthias, Eccles, Diana, Easton, Douglas F., Edwards, Robert P., Eilber, Ursula, Ekici, Arif B., Fasching, Peter A., Fridley, Brooke L., Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G., Glasspool, Rosalind, Goode, Ellen L., Goodman, Marc T., Grownwald, Jacek, Harrington, Patricia, Harter, Philipp, Hasmad, Hanis Nazihah, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle A.T., Hillemanns, Peter, Hogdall, Estrid, Hogdall, Claus, Hosono, Satoyo, Iversen, Edwin S., Jakubowska, Anna, James, Paul, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y, Kjaer, Susanne Kruger, Kelemen, Linda E., Kellar, Melissa, Kelley, Joseph L., Kiemeney, Lambertus A., Krakstad, Camilla, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D., Lele, Shashi, Leminen, Arto, Lester, Jenny, Levine, Douglas A., Liang, Dong, Lissowska, Jolanta, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon F.A.G., Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John R., McNeish, Ian, Menon, Usha, Modugno, Francesmary, Moysich, Kirsten B., Narod, Steven A., Nedergaard, Lotte, Ness, Roberta B., Azmi, Mat Adenan Noor, Odunsi, Kunle, Olson, Sara H., Orlow, Irene, Orsulic, Sandra, Weber, Rachel Palmieri, Pearce, Celeste L., Pejovic, Tanja, Pelttari, Liisa M., Permuth-Wey, Jennifer, Phelan, Catherine M., Pike, Malcolm C., Poole, Elizabeth M., Risch, Harvey A., Rosen, Barry, Rossing, Mary Anne, Rothstein, Joseph H., Rudolph, Anja, Runnebaum, Ingo B., Rzepecka, Iwona K., Salvesen, Helga B., Schildkraut, Joellen M., Schwaab, Ira, Sellers, Thomas A., Shu, Xiao-Ou, Shvetsov, Yurii B, Siddiqui, Nadeem, Sieh, Weiva, Song, Honglin, Southey, Melissa C., Sucheston, Lara, Tangen, Ingvild L., Teo, Soo-Hwang, Terry, Kathryn L., Thompson, Pamela J., Timorek, Agnieszka, Tsai, Ya-Yu, Tworoger, Shelley S., Tyrer, Jonathan, van Altena, Anne M., Van Nieuwenhuysen, Els, Vergote, Ignace, Vierkant, Robert A., Wang-Gohrke, Shan, Walsh, Christine, Wentzensen, Nicolas, Whittemore, Alice S., Wicklund, Kristine G., Wilkens, Lynne R., Woo, Yin-Ling, Wu, Xifeng, Wu, Anna H., Yang, Hannah, Zheng, Wei, and Ziogas, Argyrios

Published
2015
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31. Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest

Author

Siscovick, David S., Raghunathan, T.E., King, Irena, Weinmann, Sheila, Wicklund, Kristine G., Albright, Jennifer, Bovbjerg, Viktor, Arbogast, Patrick, Smith, Heidi, Kushi, Lawrence H., Cobb, Leonard A., Copass, Michael K., Psaty, Bruce M., Lemaitre, Rozenn, Retzlaff, Barbara, Childs, Marian, and Knopp, Robert H.

Subjects
Cardiac arrest -- Health aspects, Fish oils in human nutrition -- Health aspects
Abstract

Eating more fish may lower the risk of cardiac arrest. Fish contain long-chain n-3 polyunsaturated fatty acids, which can be incorporated into blood cell membranes and change their physiological properties. Researchers identified 334 people who had experienced a cardiac arrest between 1988 and 1994 in King County, Washington. They chose 493 healthy volunteers from the community as the control group. In both groups, people with heart disease were excluded. Spouses were asked to estimate fish intake and membrane fatty acid composition was measured in samples of the participants' blood. Eating the equivalent of two fish meals a month reduced the risk of cardiac arrest by 30% and the equivalent of one fish meal a week reduced the risk by 50% compared to those who ate no fish. Increased amounts of n-3 fatty acids in red blood cell membranes was also associated with a lower risk of cardiac arrest., Objective. - To assess whether the dietary intake of long-chain n-3 polyunsaturated fatty acids from seafood, assessed both directly and indirectly through a biomarker, is associated with a reduced risk of primary cardiac arrest. Design. - Population-based case-control study. Setting. - Seattle and suburban King County, Washington. Participants. - A total of 334 case patients with primary cardiac arrest, aged 25 to 74 years, attended by paramedics during 1988 to 1994 and 493 population-based control cases and controls, matched for age and sex, randomly identified from the community. All cases and controls were free of prior clinical heart disease, major comorbidity, and use of fish oil supplements. Measures of Exposure. - Spouses of case patients and control subjects were interviewed to quantity dietary n-3 polyunsaturated fatty acid intake from seafood during the prior month and other clinical characteristics. Blood specimens from 82 cases (collected in the field) and 108 controls were analyzed to determine red blood cell membrane fatty acid composition, a biomarker of dietary n-3 polyunsaturated fatty acid intake. Results. - Compared with no dietary intake of eicosapentaenoic acid ([C.sub.20]:5n-3) and docosahexaenoic acid ([C.sub.22]:6n-3), an intake of 5.5 g of n-3 fatty acids per month (the mean of the third quartile and the equivalent of one fatty fish meal per week) was associated with a 50% reduction in the risk of primary cardiac arrest (odds ratio [OR], 0.5; 95% confidence interval [Cl], 0.4 to 0.8), after adjustment for potential confounding factors. Compared with a red blood cell membrane n-3 polyunsaturated fatty acid level of 3.3% of total fatty acids (the mean of the lowest quartile), a red blood cell n-3 polyunsaturated fatty acid level of 5.0% of total fatty acids (the mean of the third quartile) was associated with a 70% reduction in the risk of primary cardiac arrest (OR, 0.3; 95% Cl, 0.2 to 0.6). Conclusion. - Dietary intake of n-3 polyunsaturated fatty acids from seafood is associated with a reduced risk of primary cardiac arrest. (JAMA. 1995;274:1363-1367)

Published
1995

32. Diuretic therapy for hypertension and the risk of primary cardiac arrest

Author

Siscovick, David S., Raghunathan, T.E., Psaty, Bruce M., Koepsell, Thomas D., Wicklund, Kristine G., Lin, Xihong, Cobb, Leonard, Rautaharju, Pentii M., Copass, Michael K., and Wagner, Edward H.

Subjects
Diuretics -- Evaluation, Hypertension -- Drug therapy, Thiazides -- Evaluation, Sudden death -- Risk factors
Abstract

The addition of potassium-sparing diuretics to thiazide diuretic therapy for the treatment of high blood pressure (hypertension) may lower the risk of sudden death from cardiac arrest. The records of 114 patients with hypertension who had cardiac arrest were compared with the records of 535 patients with hypertension. Patients receiving combined potassium-sparing and thiazide diuretic treatment had a lower risk of sudden death than those treated with just thiazide. However, potassium supplements combined with thiazide did not lower the risk of cardiac arrest. Low-dose thiazide therapy was associated with a lower risk of death than moderate-dose regimens.

Published
1994

35. Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies

Author

Praestegaard, Camilla, Jensen, Allan, Jensen, Signe M, Nielsen, Thor SS, Webb, Penelope M, Nagle, Christina M, DeFazio, Anna, Australian Ovarian Cancer Study Group, Høgdall, Estrid, Rossing, Mary Anne, Doherty, Jennifer A, Wicklund, Kristine G, Goodman, Marc T, Modugno, Francesmary, Moysich, Kirsten, Ness, Roberta B, Edwards, Robert, Matsuo, Keitaro, Hosono, Satoyo, Goode, Ellen L, Winham, Stacey J, Fridley, Brooke L, Cramer, Daniel W, Terry, Kathryn L, Schildkraut, Joellen M, Berchuck, Andrew, Bandera, Elisa V, Paddock, Lisa E, Massuger, Leon F, Wentzensen, Nicolas, Pharoah, Paul, Song, Honglin, Whittemore, Alice, McGuire, Valerie, Sieh, Weiva, Rothstein, Joseph, Anton-Culver, Hoda, Ziogas, Argyrios, Menon, Usha, Gayther, Simon A, Ramus, Susan J, Gentry-Maharaj, Alexandra, Wu, Anna H, Pearce, Celeste L, Pike, Malcolm, Lee, Alice W, Sutphen, Rebecca, Chang-Claude, Jenny, Risch, Harvey A, Kjaer, Susanne K, and Ovarian Cancer Association Consortium

Subjects
Australian Ovarian Cancer Study Group, Adult, Ovarian Cancer Association Consortium, Oncology and Carcinogenesis, cigarette smoking, survival, Young Adult, Rare Diseases, Risk Factors, Neoplasms, Ovarian Epithelial, Tobacco, 80 and over, Humans, Oncology & Carcinogenesis, Proportional Hazards Models, Aged, Cancer, Ovarian Neoplasms, Tobacco Smoke and Health, Prevention, Smoking, Carcinoma, Glandular and Epithelial, Middle Aged, Ovarian Cancer, Case-Control Studies, Female, pooled analysis
Abstract

Cigarette smoking is associated with an increased risk of developing mucinous ovarian tumors but whether it is associated with ovarian cancer survival overall or for the different histotypes is unestablished. Furthermore, it is unknown whether the association between cigarette smoking and survival differs according to strata of ovarian cancer stage at diagnosis. In a large pooled analysis, we evaluated the association between various measures of cigarette smoking and survival among women with epithelial ovarian cancer. We obtained data from 19 case-control studies in the Ovarian Cancer Association Consortium (OCAC), including 9,114 women diagnosed with ovarian cancer. Cox regression models were used to estimate adjusted study-specific hazard ratios (HRs), which were combined into pooled hazard ratios (pHR) with corresponding 95% confidence intervals (CIs) under random effects models. Overall, 5,149 (57%) women died during a median follow-up period of 7.0 years. Among women diagnosed with ovarian cancer, both current (pHR = 1.17, 95% CI: 1.08-1.28) and former smokers (pHR = 1.10, 95% CI: 1.02-1.18) had worse survival compared with never smoking women. In histotype-stratified analyses, associations were observed for mucinous (current smoking: pHR = 1.91, 95% CI: 1.01-3.65) and serous histotypes (current smoking: pHR = 1.11, 95% CI: 1.00-1.23; former smoking: pHR = 1.12, 95% CI: 1.04-1.20). Further, our results suggested that current smoking has a greater impact on survival among women with localized than disseminated disease. The identification of cigarette smoking as a modifiable factor associated with survival has potential clinical importance as a focus area to improve ovarian cancer prognosis.

Published
2017

36. Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility

Author

Earp, Madalene, primary, Tyrer, Jonathan P., additional, Winham, Stacey J., additional, Lin, Hui-Yi, additional, Chornokur, Ganna, additional, Dennis, Joe, additional, Aben, Katja K. H., additional, Anton‐Culver, Hoda, additional, Antonenkova, Natalia, additional, Bandera, Elisa V., additional, Bean, Yukie T., additional, Beckmann, Matthias W., additional, Bjorge, Line, additional, Bogdanova, Natalia, additional, Brinton, Louise A., additional, Brooks-Wilson, Angela, additional, Bruinsma, Fiona, additional, Bunker, Clareann H., additional, Butzow, Ralf, additional, Campbell, Ian G., additional, Carty, Karen, additional, Chang-Claude, Jenny, additional, Cook, Linda S., additional, Cramer, Daniel W, additional, Cunningham, Julie M., additional, Cybulski, Cezary, additional, Dansonka-Mieszkowska, Agnieszka, additional, Despierre, Evelyn, additional, Doherty, Jennifer A., additional, Dörk, Thilo, additional, du Bois, Andreas, additional, Dürst, Matthias, additional, Easton, Douglas F., additional, Eccles, Diana M., additional, Edwards, Robert P., additional, Ekici, Arif B., additional, Fasching, Peter A., additional, Fridley, Brooke L., additional, Gentry-Maharaj, Aleksandra, additional, Giles, Graham G., additional, Glasspool, Rosalind, additional, Goodman, Marc T., additional, Gronwald, Jacek, additional, Harter, Philipp, additional, Hein, Alexander, additional, Heitz, Florian, additional, Hildebrandt, Michelle A. T., additional, Hillemanns, Peter, additional, Hogdall, Claus K., additional, Høgdall, Estrid, additional, Hosono, Satoyo, additional, Iversen, Edwin S., additional, Jakubowska, Anna, additional, Jensen, Allan, additional, Ji, Bu-Tian, additional, Jung, Audrey Y., additional, Karlan, Beth Y., additional, Kellar, Melissa, additional, Kiemeney, Lambertus A., additional, Kiong Lim, Boon, additional, Kjaer, Susanne K., additional, Krakstad, Camilla, additional, Kupryjanczyk, Jolanta, additional, Lambrechts, Diether, additional, Lambrechts, Sandrina, additional, Le, Nhu D., additional, Lele, Shashi, additional, Lester, Jenny, additional, Levine, Douglas A., additional, Li, Zheng, additional, Liang, Dong, additional, Lissowska, Jolanta, additional, Lu, Karen, additional, Lubinski, Jan, additional, Lundvall, Lene, additional, Massuger, Leon F. A. G., additional, Matsuo, Keitaro, additional, McGuire, Valerie, additional, McLaughlin, John R., additional, McNeish, Iain, additional, Menon, Usha, additional, Milne, Roger L., additional, Modugno, Francesmary, additional, Moysich, Kirsten B., additional, Ness, Roberta B., additional, Nevanlinna, Heli, additional, Odunsi, Kunle, additional, Olson, Sara H., additional, Orlow, Irene, additional, Orsulic, Sandra, additional, Paul, James, additional, Pejovic, Tanja, additional, Pelttari, Liisa M., additional, Permuth, Jenny B., additional, Pike, Malcolm C., additional, Poole, Elizabeth M., additional, Rosen, Barry, additional, Rossing, Mary Anne, additional, Rothstein, Joseph H., additional, Runnebaum, Ingo B., additional, Rzepecka, Iwona K., additional, Schernhammer, Eva, additional, Schwaab, Ira, additional, Shu, Xiao-Ou, additional, Shvetsov, Yurii B., additional, Siddiqui, Nadeem, additional, Sieh, Weiva, additional, Song, Honglin, additional, Southey, Melissa C., additional, Spiewankiewicz, Beata, additional, Sucheston-Campbell, Lara, additional, Tangen, Ingvild L., additional, Teo, Soo-Hwang, additional, Terry, Kathryn L., additional, Thompson, Pamela J., additional, Thomsen, Lotte, additional, Tworoger, Shelley S., additional, van Altena, Anne M., additional, Vergote, Ignace, additional, Vestrheim Thomsen, Liv Cecilie, additional, Vierkant, Robert A., additional, Walsh, Christine S., additional, Wang-Gohrke, Shan, additional, Wentzensen, Nicolas, additional, Whittemore, Alice S., additional, Wicklund, Kristine G., additional, Wilkens, Lynne R., additional, Woo, Yin-Ling, additional, Wu, Anna H., additional, Wu, Xifeng, additional, Xiang, Yong-Bing, additional, Yang, Hannah, additional, Zheng, Wei, additional, Ziogas, Argyrios, additional, Lee, Alice W, additional, Pearce, Celeste L., additional, Berchuck, Andrew, additional, Schildkraut, Joellen M., additional, Ramus, Susan J., additional, Monteiro, Alvaro N. A., additional, Narod, Steven A., additional, Sellers, Thomas A., additional, Gayther, Simon A., additional, Kelemen, Linda E., additional, Chenevix-Trench, Georgia, additional, Risch, Harvey A., additional, Pharoah, Paul D. P., additional, Goode, Ellen L., additional, and Phelan, Catherine M., additional

Published
2018
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38. Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer

Author

Hampras, Shalaka S., Sucheston-Campbell, Lara E., Cannioto, Rikki, Chang-Claude, Jenny, Modugno, Francesmary, Dörk, Thilo, Hillemanns, Peter, Preus, Leah, Knutson, Keith L., Wallace, Paul K., Hong, Chi-Chen, Friel, Grace, Davis, Warren, Nesline, Mary, Pearce, Celeste L., Kelemen, Linda E., Goodman, Marc T., Bandera, Elisa V., Terry, Kathryn L., Schoof, Nils, Eng, Kevin H., Clay, Alyssa, Singh, Prashant K., Joseph, Janine M., Aben, Katja K.H., Anton-Culver, Hoda, Antonenkova, Natalia, Baker, Helen, Bean, Yukie, Beckmann, Matthias W., Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A., Brooks-Wilson, Angela, Bruinsma, Fiona, Butzow, Ralf, Campbell, Ian G., Carty, Karen, Cook, Linda S., Cramer, Daniel W., Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, Dennis, Joe, Despierre, Evelyn, Dicks, Ed, Doherty, Jennifer A., du Bois, Andreas, Dürst, Matthias, Easton, Doug, Eccles, Diana, Edwards, Robert P., Ekici, Arif B., Fasching, Peter A., Fridley, Brooke L., Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G., Glasspool, Rosalind, Gronwald, Jacek, Harrington, Patricia, Harter, Philipp, Hasmad, Hanis Nazihah, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle A.T., Hogdall, Claus, Hogdall, Estrid, Hosono, Satoyo, Iversen, Edwin S., Jakubowska, Anna, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y., Kellar, Melissa, Kelley, Joseph L., Kiemeney, Lambertus A., Klapdor, Rüdiger, Kolomeyevskaya, Nonna, Krakstad, Camilla, Kjaer, Susanne K., Kruszka, Bridget, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D., Lee, Alice W., Lele, Shashikant, Leminen, Arto, Lester, Jenny, Levine, Douglas A., Liang, Dong, Lissowska, Jolanta, Liu, Song, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon F.A.G., Matsuo, Keitaro, McGuire, Valeria, McLaughlin, John R., Mcneish, Iain, Menon, Usha, Moes-Sosnowska, Joanna, Narod, Steven A., Nedergaard, Lotte, Nevalinna, Heli, Nickels, Stefan, Nevanlinna, Heli, Olson, Sara H., Orlow, Irene, Weber, Rachel Palmieri, Paul, James, Pejovic, Tanja, Pelttari, Liisa M., Perkins, Barbara, Permuth-Wey, Jenny, Pike, Malcolm C., Plisiecka-Halasa, Joanna, Poole, Elizabeth M., Risch, Harvey A., Rossing, Mary Anne, Rothstein, Joseph H., Rudolph, Anja, Runnebaum, Ingo B., Rzepecka, Iwona K., Salvesen, Helga B., Schernhammer, Eva, Schmitt, Kristina, Schwaab, Ira, Shu, Xiao-Ou, Shvetsov, Yurii B., Siddiqui, Nadeem, Sieh, Weiva, Song, Honglin, Southey, Melissa C., Tangen, Ingvild L., Teo, Soo-Hwang, Thompson, Pamela J., Timorek, Agnieszka, Tsai, Ya-Yu, Tworoger, Shelley S., Tyrer, Jonathan, van Altena, Anna M., Vergote, Ignace, Vierkant, Robert A., Walsh, Christine, Wang-Gohrke, Shan, Wentzensen, Nicolas, Whittemore, Alice S., Wicklund, Kristine G., Wilkens, Lynne R., Wu, Anna H., Wu, Xifeng, Woo, Yin-Ling, Yang, Hannah, Zheng, Wei, Ziogas, Argyrios, Gayther, Simon A., Ramus, Susan J., Sellers, Thomas A., Schildkraut, Joellen M., Phelan, Catherine M., Berchuck, Andrew, Chenevix-Trench, Georgia, Cunningham, Julie M., Pharoah, Paul P., Ness, Roberta B., Odunsi, Kunle, Goode, Ellen L., and Moysich, Kirsten B.

Subjects
endocrine system diseases, female genital diseases and pregnancy complications
Abstract

Background: Regulatory T (Treg) cells, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and, thus, variants in genes encoding Treg cell immune molecules could be associated with ovarian cancer.\ud Methods: In a population of 15,596 epithelial ovarian cancer (EOC) cases and 23,236 controls, we measured genetic associations of 1,351 SNPs in Treg cell pathway genes with odds of ovarian cancer and tested pathway and gene-level associations, overall and by histotype, for the 25 genes, using the admixture likelihood (AML) method. The most significant single SNP associations were tested for correlation with expression levels in 44 ovarian cancer patients.\ud Results: The most significant global associations for all genes in the pathway were seen in endometrioid (p = 0.082) and clear cell (p = 0.083), with the most significant gene level association seen with TGFBR2 (p = 0.001) and clear cell EOC. Gene associations with histotypes at p < 0.05 included: IL12 (p = 0.005 and p = 0.008, serous and high-grade serous, respectively), IL8RA (p = 0.035, endometrioid and mucinous), LGALS1 (p = 0.03, mucinous), STAT5B (p = 0.022, clear cell), TGFBR1 (p = 0.021 endometrioid) and TGFBR2 (p = 0.017 and p = 0.025, endometrioid and mucinous, respectively).\ud Conclusions: Common inherited gene variation in Treg cell pathways shows some evidence of germline genetic contribution to odds of EOC that varies by histologic subtype and may be associated with mRNA expression of immune-complex receptor in EOC patients.

Published
2016

39. Pelvic Inflammatory Disease and the Risk of Ovarian Cancer and Borderline Ovarian Tumors: A Pooled Analysis of 13 Case-Control Studies

Author

Rasmussen, Christina B., primary, Kjaer, Susanne K., additional, Albieri, Vanna, additional, Bandera, Elisa V., additional, Doherty, Jennifer A., additional, Høgdall, Estrid, additional, Webb, Penelope M., additional, Jordan, Susan J., additional, Rossing, Mary Anne, additional, Wicklund, Kristine G., additional, Goodman, Marc T., additional, Modugno, Francesmary, additional, Moysich, Kirsten B., additional, Ness, Roberta B., additional, Edwards, Robert P., additional, Schildkraut, Joellen M., additional, Berchuck, Andrew, additional, Olson, Sara H., additional, Kiemeney, Lambertus A., additional, Massuger, Leon F. A. G., additional, Narod, Steven A., additional, Phelan, Catherine M., additional, Anton-Culver, Hoda, additional, Ziogas, Argyrios, additional, Wu, Anna H., additional, Pearce, Celeste L., additional, Risch, Harvey A., additional, and Jensen, Allan, additional

Published
2016
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40. Genome-wide significant risk associations for mucinous ovarian carcinoma (vol 47, pg 888, 2015)

Author

Kelemen, Linda E., Lawrenson, Kate, Tyrer, Jonathan, Li, Qiyuan, Lee, Janet M., Seo, Ji-Heui, Phelan, Catherine M., Beesley, Jonathan, Chen, Xiaoqing, Spindler, Tassja J., Aben, Katja K. H., Anton-Culver, Hoda, Antonenkova, Natalia, Baker, Helen, Bandera, Elisa V., Bean, Yukie, Beckmann, Matthias W., Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A., Brooks-Wilson, Angela, Bruinsma, Fiona, Butzow, Ralf, Campbell, Ian G., Carty, Karen, Chang-Claude, Jenny, Chen, Y. Ann, Chen, Zhihua, Cook, Linda S., Cramer, Daniel W., Cunningham, Julie M., Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, Dennis, Joe, Dicks, Ed, Doherty, Jennifer A., Doerk, Thilo, Du Bois, Andreas, Duerst, Matthias, Eccles, Diana, Easton, Douglas T., Edwards, Robert P., Eilber, Ursula, Ekici, Arif B., Engelholm, Svend Aage, Fasching, Peter A., Fridley, Brooke L., Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G., Glasspool, Rosalind, Goode, Ellen L., Goodman, Marc T., Grownwald, Jacek, Harrington, Patricia, Harter, Philipp, Hasmad, Hanis Nazihah, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle A. T., Hillemanns, Peter, Hogdall, Estrid, Hogdall, Claus, Hosono, Satoyo, Iversen, Edwin S., Jakubowska, Anna, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y., Kellar, Melissa, Kelley, Joseph L., Lambertus Kiemeney, Krakstad, Camilla, Kjaer, Susanne K., Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D., Lee, Alice W., Lele, Shashi, Leminen, Arto, Lester, Jenny, Levine, Douglas A., Liang, Dong, Lissowska, Jolanta, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon F. A. G., Matsuo, Keitaro, Mcguire, Valerie, Mclaughlin, John R., Mcneish, Iain, Menon, Usha, Modugno, Francesmary, Moes-Sosnowska, Joanna, Moysich, Kirsten B., Narod, Steven A., Nedergaard, Lotte, Ness, Roberta B., Nevanlinna, Heli, Adenan, Noor Azmi Mat, Odunsi, Kunle, Olson, Sara H., Orlow, Irene, Orsulic, Sandra, Weber, Rachel Palmieri, Paul, James, Pearce, Celeste Leigh, Pejovic, Tanja, Pelttari, Liisa M., Permuth-Wey, Jennifer, Pike, Malcolm C., Poole, Elizabeth M., Ramus, Susan J., Risch, Harvey A., Rosen, Barry, Rossing, Mary Anne, Rothstein, Joseph H., Rudolph, Anja, Runnebaum, Ingo B., Rzepecka, Iwona K., Salvesen, Helga B., Schildkraut, Joellen M., Schwaab, Ira, Shu, Xiao-Ou, Shvetsov, Yurii B., Siddiqui, Nadeem, Sieh, Weiva, Song, Honglin, Southey, Melissa C., Sucheston, Lara, Tangen, Ingvild L., Teo, Soo-Hwang, Terry, Kathryn L., Thompson, Pamela J., Tworoger, Shelley S., Altena, Anne M., Nieuwenhuysen, Els, Vergote, Ignace, Vierkant, Robert A., Wang-Gohrke, Shan, Walsh, Christine, Wentzensen, Nicolas, Whittemore, Alice S., Wicklund, Kristine G., Wilkens, Lynne R., Sawicki, Wlodzimierz, Woo, Yin-Ling, Wu, Xifeng, Wu, Anna H., Yang, Hannah, Zheng, Wei, Ziogas, Argyrios, Sellers, Thomas A., Freedman, Matthew L., Chenevix-Trench, Georgia, Pharoah, Paul D. P., Gayther, Simon A., Berchuck, Andrew, Australian Canc Study, Australian Ovarian Canc Study Grp, and Ovarian Canc Assoc Consortium

Published
2015

41. Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk

Author

Cannioto, Rikki, primary, LaMonte, Michael J., additional, Risch, Harvey A., additional, Hong, Chi-Chen, additional, Sucheston-Campbell, Lara E., additional, Eng, Kevin H., additional, Szender, J. Brian, additional, Chang-Claude, Jenny, additional, Schmalfeldt, Barbara, additional, Klapdor, Ruediger, additional, Gower, Emily, additional, Minlikeeva, Albina N., additional, Zirpoli, Gary, additional, Bandera, Elisa V., additional, Berchuck, Andrew, additional, Cramer, Daniel, additional, Doherty, Jennifer A., additional, Edwards, Robert P., additional, Fridley, Brooke L., additional, Goode, Ellen L., additional, Goodman, Marc T., additional, Hogdall, Estrid, additional, Hosono, Satoyo, additional, Jensen, Allan, additional, Jordan, Susan, additional, Kjaer, Susanne K., additional, Matsuo, Keitaro, additional, Ness, Roberta B., additional, Olsen, Catherine M., additional, Olson, Sara H., additional, Pearce, Celeste Leigh, additional, Pike, Malcolm C., additional, Rossing, Mary Anne, additional, Szamreta, Elizabeth A., additional, Thompson, Pamela J., additional, Tseng, Chiu-Chen, additional, Vierkant, Robert A., additional, Webb, Penelope M., additional, Wentzensen, Nicolas, additional, Wicklund, Kristine G., additional, Winham, Stacey J., additional, Wu, Anna H., additional, Modugno, Francesmary, additional, Schildkraut, Joellen M., additional, Terry, Kathryn L., additional, Kelemen, Linda E., additional, and Moysich, Kirsten B., additional

Published
2016
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42. The association between socioeconomic status and tumour stage at diagnosis of ovarian cancer: A pooled analysis of 18 case-control studies

Author

Præstegaard, Camilla, primary, Kjaer, Susanne K., additional, Nielsen, Thor S.S., additional, Jensen, Signe M., additional, Webb, Penelope M., additional, Nagle, Christina M., additional, Høgdall, Estrid, additional, Risch, Harvey A., additional, Rossing, Mary Anne, additional, Doherty, Jennifer A., additional, Wicklund, Kristine G., additional, Goodman, Marc T., additional, Modugno, Francesmary, additional, Moysich, Kirsten, additional, Ness, Roberta B., additional, Edwards, Robert P., additional, Goode, Ellen L., additional, Winham, Stacey J., additional, Fridley, Brooke L., additional, Cramer, Daniel W., additional, Terry, Kathryn L., additional, Schildkraut, Joellen M., additional, Berchuck, Andrew, additional, Bandera, Elisa V., additional, Paddock, Lisa, additional, Kiemeney, Lambertus A., additional, Massuger, Leon F., additional, Wentzensen, Nicolas, additional, Pharoah, Paul, additional, Song, Honglin, additional, Whittemore, Alice S., additional, McGuire, Valerie, additional, Sieh, Weiva, additional, Rothstein, Joseph, additional, Anton-Culver, Hoda, additional, Ziogas, Argyrios, additional, Menon, Usha, additional, Gayther, Simon A., additional, Ramus, Susan J., additional, Gentry-Maharaj, Aleksandra, additional, Wu, Anna H., additional, Pearce, Celeste L., additional, Pike, Malcolm C., additional, Lee, Alice W., additional, Chang-Claude, Jenny, additional, and Jensen, Allan, additional

Published
2016
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43. Ovarian cancer risk, ALDH2 polymorphism and alcohol drinking: Asian data from the Ovarian Cancer Association Consortium.

Author

Ugai, Tomotaka, Kelemen, Linda E., Mizuno, Mika, Ong, Jue‐Sheng, Webb, Penelope M., Chenevix‐Trench, Georgia, on behalf of the Australian Ovarian Cancer Study Group, Wicklund, Kristine G., Doherty, Jennifer Anne, Rossing, Mary Anne, Thompson, Pamela J., Wilkens, Lynne R., Carney, Michael E., Goodman, Marc T., Schildkraut, Joellen M., Berchuck, Andrew, Cramer, Daniel W., Terry, Kathryn L., Cai, Hui, and Shu, Xiao‐Ou

Abstract

The aldehyde dehydrogenase 2 (ALDH2) polymorphism rs671 (Glu504Lys) causes ALDH2 inactivation and adverse acetaldehyde exposure among Asians, but little is known of the association between alcohol consumption and rs671 and ovarian cancer (OvCa) in Asians. We conducted a pooled analysis of Asian ancestry participants in the Ovarian Cancer Association Consortium. We included seven case‐control studies and one cohort study comprising 460 invasive OvCa cases, 37 borderline mucinous OvCa and 1274 controls of Asian descent with information on recent alcohol consumption. Pooled odds ratios (OR) with 95% confidence intervals (CI) for OvCa risk associated with alcohol consumption, rs671 and their interaction were estimated using logistic regression models adjusted for potential confounders. No significant association was observed for daily alcohol intake with invasive OvCa (OR comparing any consumption to none = 0.83; 95% CI = 0.58‐1.18) or with individual histotypes. A significant decreased risk was seen for carriers of one or both Lys alleles of rs671 for invasive mucinous OvCa (OR = 0.44; 95% CI = 0.20‐0.97) and for invasive and borderline mucinous tumors combined (OR = 0.48; 95% CI = 0.26‐0.89). No significant interaction was observed between alcohol consumption and rs671 genotypes. In conclusion, self‐reported alcohol consumption at the quantities estimated was not associated with OvCa risk among Asians. Because the rs671 Lys allele causes ALDH2 inactivation leading to increased acetaldehyde exposure, the observed inverse genetic association with mucinous ovarian cancer is inferred to mean that alcohol intake may be a risk factor for this histotype. This association will require replication in a larger sample. [ABSTRACT FROM AUTHOR]

Published
2018
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44. Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case–control studies

Author

Cushing-Haugen, Kara L, Pearce, Celeste Leigh, Doherty, Jennifer A, Anton-Culver, Hoda, Webb, Penelope M, Titus, Linda J, Brewster, Wendy, Fridley, Brooke L, Vitonis, Allison F, Larson, Melissa C, Kjaer, Susanne K, Chang-Claude, Jenny, Ziogas, Argyrios, Wicklund, Kristine G, Rossing, Mary Anne, Goodman, Marc T, Lurie, Galina, Moysich, Kirsten, Nagle, Christina M, Goode, Ellen L, Templeman, Claire, Hein, Rebecca, Wilkens, Lynne R, Lee, Alice, Schildkraut, Joellen M, Near, Aimee M, Cramer, Daniel W, Terry, Kathryn L, Palmieri, Rachel T, Jensen, Allan, Hogdall, Estrid, and Carney, Michael E

Subjects
endocrine system diseases
Abstract

Endometriosis is a risk factor for epithelial ovarian cancer; however, whether this risk extends to all invasive histological subtypes or borderline tumours is not clear. We undertook an international collaborative study to assess the association between endometriosis and histological subtypes of ovarian cancer.

Published
2012
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45. Adult body mass index and risk of ovarian cancer by subtype: a Mendelian randomization study.

Author

Dixon, Suzanne C., Nagle, Christina M., Thrift, Aaron P., Pharoah, Paul D. P., Leigh Pearce, Celeste, Wei Zheng, Painter, Jodie N., Chenevix-Trench, Georgia, Fasching, Peter A., Beckmann, Matthias W., Lambrechts, Diether, Vergote, Ignace, Lambrechts, Sandrina, Van Nieuwenhuysen, Els, Rossing, Mary Anne, Doherty, Jennifer A., Wicklund, Kristine G., Chang-Claude, Jenny, Rudolph, Anja, and Moysich, Kirsten B.

Subjects
OVARIAN cancer, BODY mass index, WEIGHT loss, SINGLE nucleotide polymorphisms, OBESITY, CANCER risk factors, OBESITY complications, ALLELES, GENETIC polymorphisms, MULTIVARIATE analysis, OVARIAN tumors, RESEARCH funding, GENETIC markers, LOGISTIC regression analysis, SEQUENCE analysis, GENOTYPES
Abstract

Background: Observational studies have reported a positive association between body mass index (BMI) and ovarian cancer risk. However, questions remain as to whether this represents a causal effect, or holds for all histological subtypes. The lack of association observed for serous cancers may, for instance, be due to disease-associated weight loss. Mendelian randomization (MR) uses genetic markers as proxies for risk factors to overcome limitations of observational studies. We used MR to elucidate the relationship between BMI and ovarian cancer, hypothesizing that genetically predicted BMI would be associated with increased risk of non-high grade serous ovarian cancers (non-HGSC) but not HGSC.Methods: We pooled data from 39 studies (14 047 cases, 23 003 controls) in the Ovarian Cancer Association Consortium. We constructed a weighted genetic risk score (GRS, partial F-statistic = 172), summing alleles at 87 single nucleotide polymorphisms previously associated with BMI, weighting by their published strength of association with BMI. Applying two-stage predictor-substitution MR, we used logistic regression to estimate study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted BMI and risk, and pooled these using random-effects meta-analysis.Results: Higher genetically predicted BMI was associated with increased risk of non-HGSC (pooled OR = 1.29, 95% CI 1.03-1.61 per 5 units BMI) but not HGSC (pooled OR = 1.06, 95% CI 0.88-1.27). Secondary analyses stratified by behaviour/subtype suggested that, consistent with observational data, the association was strongest for low-grade/borderline serous cancers (OR = 1.93, 95% CI 1.33-2.81).Conclusions: Our data suggest that higher BMI increases risk of non-HGSC, but not the more common and aggressive HGSC subtype, confirming the observational evidence. [ABSTRACT FROM AUTHOR]

Published
2016
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46. Shared genetics underlying epidemiological association between endometriosis and ovarian cancer.

Author

Yi Lu, Cuellar-Partida, Gabriel, Painter, Jodie N., Nyholt, Dale R., Morris, Andrew P., Fasching, Peter A., Hein, Alexander, Burghaus, Stefanie, Beckmann, Matthias W., Lambrechts, Diether, Van Nieuwenhuysen, Els, Vergote, Ignace, Vanderstichele, Adriaan, Doherty, Jennifer Anne, Rossing, Mary Anne, Wicklund, Kristine G., Chang-Claude, Jenny, Eilber, Ursula, Rudolph, Anja, and Shan Wang-Gohrke

Published
2015
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