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359 results on '"Wibbelt, Gudrun"'

19. Hantavirus Brno loanvirus is highly specific to the common noctule bat (Nyctalus noctula) and widespread in Central Europe

Author

Dafalla, Maysaa, primary, Orłowska, Anna, additional, Keleş, Sinan Julian, additional, Straková, Petra, additional, Schlottau, Kore, additional, Jeske, Kathrin, additional, Hoffmann, Bernd, additional, Wibbelt, Gudrun, additional, Smreczak, Marcin, additional, Müller, Thomas, additional, Freuling, Conrad Martin, additional, Wang, Xuejing, additional, Rola, Jerzy, additional, Drewes, Stephan, additional, Fereidouni, Sasan, additional, Heckel, Gerald, additional, and Ulrich, Rainer G., additional

Published
2022
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32. Staphylococcus Aureus Isolates From Eurasian Beavers (Castor Fiber) Carry a Novel Phage-borne Bicomponent Leukocidin Related to the Panton-valentine Leukocidin

Author

Monecke, Stefan, primary, Feßler, Andrea T., additional, Burgold-Voigt, Sindy, additional, Krüger, Henrike, additional, Mühldorfer, Kristin, additional, Wibbelt, Gudrun, additional, Liebler-Tenorio, Elisabeth M., additional, Reinicke, Martin, additional, Braun, Sascha D., additional, Hanke, Dennis, additional, Diezel, Celia, additional, Müller, Elke, additional, Loncaric, Igor, additional, Schwarz, Stefan, additional, and Ehricht, Ralf, additional

Published
2021
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33. Animal Species Identification of Meat Using MALDI-TOF Mass Spectrometry

Author

Rau, J��rg, Hiller, Ekkehard, M��nnig, Annegret, Dyk, Martin, Wenniger, Olivera, Stoll, Philipp, Wibbelt, Gudrun, and Schreiter, Pat

Subjects
FOS: Chemical sciences
Abstract

We describe the animal species identification of meat using MALDI-TOF mass spectroscopy including the development and validation of a reliable method, qualified for use in the accredited official food-control laboratory. Previous publications had shown the potential of MALDI-TOF MS for animal species differentiation of several kind of food, including meat. Our aim was to establish a rapid and reliable method by means of a simplified sample preparation without prior tryptic digest, an existing popular MALDI system, an independent extensive reference database, and an adequate validation concept. In contrast to the previous works, we consequently use the MALDI user platform “MALDI-UP” to give other food control laboratories the possibility of exchanging reference and validation spectra.

Published
2021

35. How to Start Up a National Wildlife Health Surveillance Programme

Author

Lawson, Becki, primary, Neimanis, Aleksija, additional, Lavazza, Antonio, additional, López-Olvera, Jorge Ramón, additional, Tavernier, Paul, additional, Billinis, Charalambos, additional, Duff, James Paul, additional, Mladenov, Daniel T., additional, Rijks, Jolianne M., additional, Savić, Sara, additional, Wibbelt, Gudrun, additional, Ryser-Degiorgis, Marie-Pierre, additional, and Kuiken, Thijs, additional

Published
2021
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36. How to Start Up a National Wildlife Health Surveillance Programme

Author

Lawson, Becki, Neimanis, Aleksija, Lavazza, Antonio, López-Olvera, Jorge Ramón, Tavernier, Paul, Billinis, Charalambos, Duff, James Paul, Mladenov, Daniel T, Rijks, Jolianne M, Savić, Sara, Wibbelt, Gudrun, Ryser-Degiorgis, Marie-Pierre, Kuiken, Thijs, Lawson, Becki, Neimanis, Aleksija, Lavazza, Antonio, López-Olvera, Jorge Ramón, Tavernier, Paul, Billinis, Charalambos, Duff, James Paul, Mladenov, Daniel T, Rijks, Jolianne M, Savić, Sara, Wibbelt, Gudrun, Ryser-Degiorgis, Marie-Pierre, and Kuiken, Thijs

Abstract

Whilst multiple countries in Europe have wildlife health surveillance (WHS) programmes, they vary in scope. In many countries, coordinated general surveillance at a national scale is not conducted and the knowledge of wildlife health status in Europe remains limited. Learning lessons from countries with established systems may help others to effectively implement WHS schemes. In order to facilitate information exchange, the WHS Network of the European Wildlife Disease Association organised a workshop to both collate knowledge and experience from countries that had started or expanded WHS programmes and to translate this information into practical recommendations. Presentations were given by invited representatives of European countries with different WHS levels. Events that led to the start-up and fostered growth spurts of WHS were highlighted, including action plan creation, partnership formation, organisation restructuring and appraisal by external audit. Challenges to programme development, such as a lack of funding, data sharing, infrastructural provision and method harmonisation, were explored. Recommendations to help overcome key challenges were summarised as: understanding and awareness; cross-sectoral scope; national-scale collaboration; harmonisation of methods; government support; academic support; other funding support; staff expertise and capacity; leadership, feedback and engagement; and threat mitigation and wildlife disease management. This resource may enable the development of WHS programmes in Europe and beyond.

Published
2021

37. How to Start Up a National Wildlife Health Surveillance Programme

Author

VPDC pathologie, dPB I&I, Lawson, Becki, Neimanis, Aleksija, Lavazza, Antonio, López-Olvera, Jorge Ramón, Tavernier, Paul, Billinis, Charalambos, Duff, James Paul, Mladenov, Daniel T, Rijks, Jolianne M, Savić, Sara, Wibbelt, Gudrun, Ryser-Degiorgis, Marie-Pierre, Kuiken, Thijs, VPDC pathologie, dPB I&I, Lawson, Becki, Neimanis, Aleksija, Lavazza, Antonio, López-Olvera, Jorge Ramón, Tavernier, Paul, Billinis, Charalambos, Duff, James Paul, Mladenov, Daniel T, Rijks, Jolianne M, Savić, Sara, Wibbelt, Gudrun, Ryser-Degiorgis, Marie-Pierre, and Kuiken, Thijs

Published
2021

38. Intravital Dynamic and Correlative Imaging of Mouse Livers Reveals Diffusion-Dominated Canalicular and Flow-Augmented Ductular Bile Flux

Author

Vartak, Nachiket, Guenther, Georgia, Joly, Florian, Damle-Vartak, Amruta, Wibbelt, Gudrun, Fickel, Joerns, Joers, Simone, Begher-Tibbe, Brigitte, Friebel, Adrian, Wansing, Kasimir, Ghallab, Ahmed, Rosselin, Marie, Boissier, Noemie, Vignon-Clementel, Irene, Hedberg, Christian, Geisler, Fabian, Hofer, Heribert, Jansen, Peter, Hoehme, Stefan, Drasdo, Dirk, Hengstler, Jan G., Vartak, Nachiket, Guenther, Georgia, Joly, Florian, Damle-Vartak, Amruta, Wibbelt, Gudrun, Fickel, Joerns, Joers, Simone, Begher-Tibbe, Brigitte, Friebel, Adrian, Wansing, Kasimir, Ghallab, Ahmed, Rosselin, Marie, Boissier, Noemie, Vignon-Clementel, Irene, Hedberg, Christian, Geisler, Fabian, Hofer, Heribert, Jansen, Peter, Hoehme, Stefan, Drasdo, Dirk, and Hengstler, Jan G.

Abstract

Background and Aims: Small-molecule flux in tissue microdomains is essential for organ function, but knowledge of this process is scant due to the lack of suitable methods. We developed two independent techniques that allow the quantification of advection (flow) and diffusion in individual bile canaliculi and in interlobular bile ducts of intact livers in living mice, namely fluorescence loss after photoactivation and intravital arbitrary region image correlation spectroscopy. Approach and Results: The results challenge the prevailing "mechano-osmotic" theory of canalicular bile flow. After active transport across hepatocyte membranes, bile acids are transported in the canaliculi primarily by diffusion. Only in the interlobular ducts is diffusion augmented by regulatable advection. Photoactivation of fluorescein bis-(5-carboxymethoxy-2-nitrobenzyl)-ether in entire lobules demonstrated the establishment of diffusive gradients in the bile canalicular network and the sink function of interlobular ducts. In contrast to the bile canalicular network, vectorial transport was detected and quantified in the mesh of interlobular bile ducts. Conclusions: The liver consists of a diffusion-dominated canalicular domain, where hepatocytes secrete small molecules and generate a concentration gradient and a flow-augmented ductular domain, where regulated water influx creates unidirectional advection that augments the diffusive flux.

Published
2021
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39. The macroscopic intestinal anatomy of a lowland tapir ( Tapirus terrestris )

Author

Hagen, Katharina, Müller, Dennis, Wibbelt, Gudrun, Ochs, Andreas, Hatt, Jean-Michel, Clauss, Marcus, Hagen, Katharina, Müller, Dennis, Wibbelt, Gudrun, Ochs, Andreas, Hatt, Jean-Michel, and Clauss, Marcus

Abstract

Tapirs are the only group among the perissodactyls for which no recent description of the gastrointestinal tract (GIT) exists. Historical depictions of the GIT of tapirs suggest a similarity to the GIT of equids, but do not resolve the question whether the isthmus at the caeco-colical junction, and at the transition from the proximal colon to the colon transversum—both evident in horses—occur in tapirs as well. Here, we describe the macroscopic anatomy of the GIT of a captive, adult lowland tapir (Tapirus terrestris). While similar to equids in terms of the overall design and, in particular, the two mentioned isthmuses, the proximal colon of the tapir appeared less pronounced than in other perissodactyls, resulting in a GIT in which the caecum appeared as the most voluminous fermentation chamber. This finding is supported by the particular location of the ileo-caecal junction, which does not visibly separate the caecum from the colon, or the caecum head from the caecum body, but enters the caecum body in its upper third.

Published
2021

41. White-nose syndrome fungus (Geomyces destructans) in bats, Europe

Author

Wibbelt, Gudrun, Kurth, Andreas, Hellmann, David, Weishaar, Manfred, Barlow, Alex, Veith, Michael, Pruger, Julia, Gorfol, Tamas, Grosche, Lena, Bontadina, Fabio, Zophel, Ulrich, Seidl, Hans-Peter, Cryan, Paul M., and Blehert, David S.

Subjects
Communicable diseases in animals -- Causes of -- Diagnosis -- Demographic aspects -- Research, Bats -- Diseases -- Research, White-nose syndrome -- Diagnosis -- Research, Health
Abstract

White-nose syndrome (WNS) is a recently emerged wildlife disease in North America, which in 4 years has resulted in unprecedented deaths of hibernating bats in the northeastern United States (1-3), [...]

Published
2010
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43. New adenovirus in bats, Germany

Author

Sonntag, Michael, Muhldorfer, Kristin, Speck, Stephanie, Wibbelt, Gudrun, and Kurth, Andreas

Subjects
Adenoviruses -- Identification and classification, Adenoviruses -- Health aspects, Adenoviruses -- Genetic aspects, Adenoviruses -- Research, Bats -- Health aspects, Bats -- Research, Polymerase chain reaction -- Usage
Abstract

Since the recent discoveries of Ebola virus, Henipavirus, and severe acute respiratory syndrome-associated coronavirus infections, interest in the role of bats as hosts for pathogens has markedly increased (1). With [...]

Published
2009
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47. Intravital Dynamic and Correlative Imaging of Mouse Livers Reveals Diffusion‐Dominated Canalicular and Flow‐Augmented Ductular Bile Flux

Author

Vartak, Nachiket, primary, Guenther, Georgia, additional, Joly, Florian, additional, Damle‐Vartak, Amruta, additional, Wibbelt, Gudrun, additional, Fickel, Jörns, additional, Jörs, Simone, additional, Begher‐Tibbe, Brigitte, additional, Friebel, Adrian, additional, Wansing, Kasimir, additional, Ghallab, Ahmed, additional, Rosselin, Marie, additional, Boissier, Noemie, additional, Vignon‐Clementel, Irene, additional, Hedberg, Christian, additional, Geisler, Fabian, additional, Hofer, Heribert, additional, Jansen, Peter, additional, Hoehme, Stefan, additional, Drasdo, Dirk, additional, and Hengstler, Jan G., additional

Published
2021
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49. Intravital dynamic and correlative imaging reveals diffusion‐dominated canalicular and flow‐augmented ductular bile flux

Author

Vartak, Nachiket, Guenther, Georgia, Joly, Florian, Damle-Vartak, Amruta, Wibbelt, Gudrun, Fickel, Jörns, Jörs, Simone, Begher-Tibbe, Brigitte, Friebel, Adrian, Wansing, Kasimir, Ghallab, Ahmed, Rosselin, Marie, Boissier, Noemie, Vignon-Clementel, Irene, Hedberg, Christian, Geisler, Fabian, Hofer, Heribert, Jansen, Peter, Hoehme, Stefan, Drasdo, Dirk, Hengstler, Jan, Leibniz Research Centre for Working Environment and Human Factors [Dortmund] (IFADO), Technische Universität Dortmund [Dortmund] (TU), Modelling and Analysis for Medical and Biological Applications (MAMBA), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Jacques-Louis Lions (LJLL (UMR_7598)), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Leibniz Institute for Zoo and Wildlife Research (IZW), Leibniz Association, University of Potsdam, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Institut für Informatik [Leipzig], Universität Leipzig [Leipzig], South Valley University [Qena], Umeå University, Numerical simulation of biological flows (REO), Sorbonne Université (SU)-Inria de Paris, Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Freie Universität Berlin, University of Amsterdam [Amsterdam] (UvA), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), University of Potsdam = Universität Potsdam, Universität Leipzig, SImulations en Médecine, BIOtechnologie et ToXicologie de systèmes multicellulaires (SIMBIOTX ), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), and ANR-16-RHUS-0005,iLite,iLite(2016)

Subjects
[SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, [SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Bile flux proceeds by diffusion in canaliculi, Augmented by advection in ducts, digestive system
Abstract

International audience; Small-molecule flux in tissue-microdomains is essential for organ function, but knowledge of this process is scant due to the lack of suitable methods. We developed two independent techniques that allow the quantification of advection (flow) and diffusion in individual bile canaliculi and in interlobular bile ducts of intact livers in living mice, namely Fluorescence Loss After Photoactivation (FLAP) and Intravital Arbitrary Region Image Correlation Spectroscopy (IVARICS). The results challenge the prevailing 'mechano-osmotic' theory of canalicular bile flow. After active transport across hepatocyte membranes bile acids are transported in the canaliculi primarily by diffusion. Only in the interlobular ducts, diffusion is augmented by regulatable advection. Photoactivation of fluorescein bis-(5-carboxymethoxy-2-nitrobenzyl)-ether (CMNB-caged fluorescein) in entire lobules demonstrated the establishment of diffusive gradients in the bile canalicular network and the sink function of interlobular ducts. In contrast to the bile canalicular network, vectorial transport was detected and quantified in the mesh of interlobular bile ducts. In conclusion, the liver consists of a diffusion dominated canalicular domain, where hepatocytes secrete small molecules and generate a concentration gradient and a flow-augmented ductular domain, where regulated water influx creates unidirectional advection that augments the diffusive flux.

Published
2020

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