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1. Corrigendum to ‘SJS/TEN 2019: From science to translation’ [J. Dermatol. Sci. 98/1 (2020) 2–12]

Author

Chang, W-C, Abe, R., Anderson, P., Anderson, W., Ardern-Jones, M.R., Beachkofsky, T.M., Bellón, T., Biala, A.K., Bouchard, C., Cavalleri, G.L., Chapman, N., Chodosh, J., Choi, H.K., Cibotti, R.R., Divito, S.J., Dewar, K., Dehaeck, U., Etminan, M., Forbes, D., Fuchs, E., Goldman, J.L., Holmes, J.H., Hope, E.A., Hung, S-L, Hsieh, C-L, Iovieno, A., Jagdeo, J., Kim, M.K., Koelle, D.M., Lacouture, M.E., Le Pallec, S., Lehloenya, R.J., Lim, R., Lowe, A., McCawley, J., Micheletti, R.G., Mockenhaupt, M., Niemeyer, K., Norcross, M.A., Oboh, D., Olteanu, C., Pasieka, H.B., Peters, J., Pirmohamed, M., Rieder, M., Saeed, H.N., Shear, N.H., Shieh, C., Straus, S., Sukasem, C., Sung, C., Trubiano, J.A., Tsou, S-Y, Ueta, M., Volpi, S., Wan, C., Wang, H., Wang, Z-Q, Weintraub, J., Whale, C., Wheatley, L.M., Whyte-Croasdaile, S., Williams, K.B., Wright, G., Yeung, S.N., Zhou, L., Chung, W-H, Phillips, E.J., Carleton, B.C., Chang, W-C, Abe, R., Anderson, P., Anderson, W., Ardern-Jones, M.R., Beachkofsky, T.M., Bellón, T., Biala, A.K., Bouchard, C., Cavalleri, G.L., Chapman, N., Chodosh, J., Choi, H.K., Cibotti, R.R., Divito, S.J., Dewar, K., Dehaeck, U., Etminan, M., Forbes, D., Fuchs, E., Goldman, J.L., Holmes, J.H., Hope, E.A., Hung, S-L, Hsieh, C-L, Iovieno, A., Jagdeo, J., Kim, M.K., Koelle, D.M., Lacouture, M.E., Le Pallec, S., Lehloenya, R.J., Lim, R., Lowe, A., McCawley, J., Micheletti, R.G., Mockenhaupt, M., Niemeyer, K., Norcross, M.A., Oboh, D., Olteanu, C., Pasieka, H.B., Peters, J., Pirmohamed, M., Rieder, M., Saeed, H.N., Shear, N.H., Shieh, C., Straus, S., Sukasem, C., Sung, C., Trubiano, J.A., Tsou, S-Y, Ueta, M., Volpi, S., Wan, C., Wang, H., Wang, Z-Q, Weintraub, J., Whale, C., Wheatley, L.M., Whyte-Croasdaile, S., Williams, K.B., Wright, G., Yeung, S.N., Zhou, L., Chung, W-H, Phillips, E.J., and Carleton, B.C.

Abstract

The authors regret not all contributing authors correctly acknowledged funding. Jonathan Peter’s IMARI-Africa project (AFRISCAR) is part of the EDCTP2 programme supported by the European Union (grant number TMA2017SF-1981 ). The authors would like to apologise for any inconvenience caused.

Published
2021

2. SJS/TEN 2019: From Science to Translation

Author

Chang, W-C, Abe, R., Anderson, P., Anderson, W., Ardern-Jones, M.R., Beachkofsky, T.M., Bellón, T., Biala, A.K., Bouchard, C., Cavalleri, G.L., Chapman, N., Chodosh, J., Choi, H.K., Cibotti, R.R., Divito, S.J., Dewar, K., Dehaeck, U., Etminan, M., Forbes, D., Fuchs, E., Goldman, J.L., Holmes, J.H., Hope, E.A., Hung, S-I, Hsieh, C-L, Iovieno, A., Jagdeo, J., Kim, M.K., Koelle, D.M., Lacouture, M.E., Le Pallec, S., Lehloenya, R.J., Lim, R., Lowe, A., McCawley, J., Micheletti, R.G., Mockenhaupt, M., Niemeyer, K., Norcross, M.A., Oboh, D., Olteanu, C., Pasieka, H.B., Peter, J., Pirmohamed, M., Rieder, M., Saeed, H.N., Shear, N.H., Shieh, C., Straus, S., Sukasem, C., Sung, C., Trubiano, J.A., Tsou, S-Y, Ueta, M., Volpi, S., Wan, C., Wang, H., Wang, Z-Q, Weintraub, J., Whale, C., Wheatley, L.M., Whyte-Croasdaile, S., Williams, K.B., Wright, G., Yeung, S.N., Zhou, L., Chung, W-H, Phillips, E.J., Carleton, B.C., Chang, W-C, Abe, R., Anderson, P., Anderson, W., Ardern-Jones, M.R., Beachkofsky, T.M., Bellón, T., Biala, A.K., Bouchard, C., Cavalleri, G.L., Chapman, N., Chodosh, J., Choi, H.K., Cibotti, R.R., Divito, S.J., Dewar, K., Dehaeck, U., Etminan, M., Forbes, D., Fuchs, E., Goldman, J.L., Holmes, J.H., Hope, E.A., Hung, S-I, Hsieh, C-L, Iovieno, A., Jagdeo, J., Kim, M.K., Koelle, D.M., Lacouture, M.E., Le Pallec, S., Lehloenya, R.J., Lim, R., Lowe, A., McCawley, J., Micheletti, R.G., Mockenhaupt, M., Niemeyer, K., Norcross, M.A., Oboh, D., Olteanu, C., Pasieka, H.B., Peter, J., Pirmohamed, M., Rieder, M., Saeed, H.N., Shear, N.H., Shieh, C., Straus, S., Sukasem, C., Sung, C., Trubiano, J.A., Tsou, S-Y, Ueta, M., Volpi, S., Wan, C., Wang, H., Wang, Z-Q, Weintraub, J., Whale, C., Wheatley, L.M., Whyte-Croasdaile, S., Williams, K.B., Wright, G., Yeung, S.N., Zhou, L., Chung, W-H, Phillips, E.J., and Carleton, B.C.

Abstract

Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are potentially life-threatening, immune-mediated adverse reactions characterized by widespread erythema, epidermal necrosis, and detachment of skin and mucosa. Efforts to grow and develop functional international collaborations and a multidisciplinary interactive network focusing on SJS/TEN as an uncommon but high burden disease will be necessary to improve efforts in prevention, early diagnosis and improved acute and long-term management. SJS/TEN 2019: From Science to Translation was a 1.5-day scientific program held April 26-27, 2019, in Vancouver, Canada. The meeting successfully engaged clinicians, researchers, and patients and conducted many productive discussions on research and patient care needs.

Published
2020

3. Major psychological complications and decreased health-related quality of life among survivors of Stevens-Johnson syndrome and toxic epidermal necrolysis

Author

Dodiuk-Gad, R.P., primary, Olteanu, C., additional, Feinstein, A., additional, Hashimoto, R., additional, Alhusayen, R., additional, Whyte-Croasdaile, S., additional, Finkelstein, Y., additional, Burnett, M., additional, Sade, S., additional, Cartotto, R., additional, Jeschke, M., additional, and Shear, N.H., additional

Published
2016
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4. Corrigendum to 'SJS/TEN 2019: From science to translation' [J. Dermatol. Sci. 98/1 (2020) 2-12].

Author

Chang WC, Abe R, Anderson P, Anderson W, Ardern-Jones MR, Beachkofsky TM, Bellón T, Biala AK, Bouchard C, Cavalleri GL, Chapman N, Chodosh J, Choi HK, Cibotti RR, Divito SJ, Dewar K, Dehaeck U, Etminan M, Forbes D, Fuchs E, Goldman JL, Holmes JH 4th, Hope EA, Hung SI, Hsieh CL, Iovieno A, Jagdeo J, Kim MK, Koelle DM, Lacouture ME, Le Pallec S, Lehloenya RJ, Lim R, Lowe A, McCawley J, McCawley J, Micheletti RG, Mockenhaupt M, Niemeyer K, Norcross MA, Oboh D, Olteanu C, Pasieka HB, Peter J, Pirmohamed M, Rieder M, Saeed HN, Shear NH, Shieh C, Straus S, Sukasem C, Sung C, Trubiano JA, Tsou SY, Ueta M, Volpi S, Wan C, Wang H, Wang ZQ, Weintraub J, Whale C, Wheatley LM, Whyte-Croasdaile S, Williams KB, Wright G, Yeung SN, Zhou L, Chung WH, Phillips EJ, and Carleton BC

Published
2021
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5. SJS/TEN 2019: From science to translation.

Author

Chang WC, Abe R, Anderson P, Anderson W, Ardern-Jones MR, Beachkofsky TM, Bellón T, Biala AK, Bouchard C, Cavalleri GL, Chapman N, Chodosh J, Choi HK, Cibotti RR, Divito SJ, Dewar K, Dehaeck U, Etminan M, Forbes D, Fuchs E, Goldman JL, Holmes JH 4th, Hope EA, Hung SI, Hsieh CL, Iovieno A, Jagdeo J, Kim MK, Koelle DM, Lacouture ME, Le Pallec S, Lehloenya RJ, Lim R, Lowe A, McCawley J, McCawley J, Micheletti RG, Mockenhaupt M, Niemeyer K, Norcross MA, Oboh D, Olteanu C, Pasieka HB, Peter J, Pirmohamed M, Rieder M, Saeed HN, Shear NH, Shieh C, Straus S, Sukasem C, Sung C, Trubiano JA, Tsou SY, Ueta M, Volpi S, Wan C, Wang H, Wang ZQ, Weintraub J, Whale C, Wheatley LM, Whyte-Croasdaile S, Williams KB, Wright G, Yeung SN, Zhou L, Chung WH, Phillips EJ, and Carleton BC

Subjects
Congresses as Topic, Global Burden of Disease, Global Health, Humans, International Cooperation, Pharmacogenetics organization & administration, Registries statistics & numerical data, Stevens-Johnson Syndrome epidemiology, Stevens-Johnson Syndrome etiology, Translational Research, Biomedical organization & administration, Health Services Needs and Demand organization & administration, Patient Care Team organization & administration, Stevens-Johnson Syndrome therapy
Abstract

Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are potentially life-threatening, immune-mediated adverse reactions characterized by widespread erythema, epidermal necrosis, and detachment of skin and mucosa. Efforts to grow and develop functional international collaborations and a multidisciplinary interactive network focusing on SJS/TEN as an uncommon but high burden disease will be necessary to improve efforts in prevention, early diagnosis and improved acute and long-term management. SJS/TEN 2019: From Science to Translation was a 1.5-day scientific program held April 26-27, 2019, in Vancouver, Canada. The meeting successfully engaged clinicians, researchers, and patients and conducted many productive discussions on research and patient care needs., (Crown Copyright © 2020. Published by Elsevier B.V. All rights reserved.)

Published
2020
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6. Severe Physical Complications among Survivors of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

Author

Olteanu C, Shear NH, Chew HF, Hashimoto R, Alhusayen R, Whyte-Croasdaile S, Finkelstein Y, Burnett M, Ziv M, Sade S, Jeschke MG, and Dodiuk-Gad RP

Subjects
Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Mouth Mucosa physiopathology, Physical Examination methods, Retrospective Studies, Skin physiopathology, Survivors, Stevens-Johnson Syndrome complications
Abstract

Introduction: Few studies have reported the physical complications among Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) survivors., Objective: The aim of this study was to comprehensively characterize the physical complications among SJS/TEN survivors and to learn about patients' perspectives of surviving SJS/TEN., Methods: SJS/TEN survivors older than 18 years of age were assessed by different methods: a medical interview; a questionnaire assessing patients' perspectives; thorough skin, oral mucous membrane, and ophthalmic examinations; and a retrospective assessment of medical records., Results: Our cohort consisted of 17 patients with a mean time of 51.6 ± 74.7 months (median 9, range 1-228) following SJS/TEN. The most common physical complications identified in the medical examination were post-inflammatory skin changes (77%), cutaneous scars (46%), dry eyes (44%), symblepharon, and chronic ocular surface inflammation (33% each). Novel physical sequelae included chronic fatigue (76%) and pruritus (53%). We also found a novel association between the number of mucous membranes affected in the acute phase of SJS/TEN and hair loss during the 6 months following hospital discharge; hair loss was reported in 88% of the group of patients who had three or more mucous membranes affected versus 29% of patients who had less than three mucous membranes involved (p = 0.0406). Following hospital discharge due to SJS/TEN, 59% of patients were followed by a dermatologist, although 88% had dermatological complications; 6% were followed by an ophthalmologist, even though 67% had ophthalmological complications; and 6% of female survivors were followed by a gynecologist, even though 27% had gynecological complications., Conclusion: Survivors of SJS/TEN suffer from severe physical complications impacting their health and lives that are mostly under recognized and not sufficiently treated by medical professionals.

Published
2018
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