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1. The Clinical Utility of a 7-Gene Biosignature on Radiation Therapy Decision Making in Patients with Ductal Carcinoma In Situ Following Breast-Conserving Surgery: An Updated Analysis of the DCISionRT® PREDICT Study

Author

Shah, Chirag, Whitworth, Pat, Vicini, Frank A., Narod, Steven, Gerber, Naamit, Jhawar, Sachin R., King, Tari A., Mittendorf, Elizabeth A., Willey, Shawna C., Rabinovich, Rachel, Gold, Linsey, Brown, Eric, Patel, Anushka, Vargo, John, Barry, Parul N., Rock, David, Friedman, Neil, Bedi, Gauri, Templeton, Sandra, Brown, Sheree, Gabordi, Robert, Riley, Lee, Lee, Lucy, Baron, Paul, Majithia, Lonika, Mirabeau-Beale, Kristina L., Reid, Vincent J., Hirsch, Arica, Hwang, Catherine, Pellicane, James, Maganini, Robert, Khan, Sadia, MacDermed, Dhara M., Small, William, Mittal, Karuna, Borgen, Patrick, Cox, Charles, Shivers, Steven C., and Bremer, Troy

Published
2024
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3. ASO Visual Abstract: The Clinical Utility of a 7-Gene Biosignature on Radiation Therapy Decision Making in Patients with Ductal Carcinoma In Situ Following Breast-Conserving Surgery: An Updated Analysis of the DCISionRT® PREDICT Study

Author

Shah, Chirag, Whitworth, Pat, Vicini, Frank A., Narod, Steven, Gerber, Naamit, Jhawar, Sachin R., King, Tari A., Mittendorf, Elizabeth A., Willey, Shawna C., Rabinovich, Rachel, Gold, Linsey, Brown, Eric, Patel, Anushka, Vargo, John, Barry, Parul N., Rock, David, Friedman, Neil, Bedi, Gauri, Templeton, Sandra, Brown, Sheree, Gabordi, Robert, Riley, Lee, Lee, Lucy, Baron, Paul, Majithia, Lonika, Mirabeau-Beale, Kristina L., Reid, Vincent J., Hirsch, Arica, Hwang, Catherine, Pellicane, James, Maganini, Robert, Khan, Sadia, MacDermed, Dhara M., Small, William, Mittal, Karuna, Borgen, Patrick, Cox, Charles, Shivers, Steven C., and Bremer, Troy

Published
2024
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4. Validation of a clinical breast cancer risk assessment tool combining a polygenic score for all ancestries with traditional risk factors

Author

Mabey, Brent, Hughes, Elisha, Kucera, Matthew, Simmons, Timothy, Hullinger, Brooke, Pederson, Holly J., Yehia, Lamis, Eng, Charis, Garber, Judy, Gary, Monique, Gordon, Ora, Klemp, Jennifer R., Mukherjee, Semanti, Vijai, Joseph, Offit, Kenneth, Olopade, Olufunmilayo I., Pruthi, Sandhya, Kurian, Allison, Robson, Mark E., Whitworth, Pat W., Pal, Tuya, Ratzel, Sarah, Wagner, Susanne, Lanchbury, Jerry S., Taber, Katherine Johansen, Slavin, Thomas P., and Gutin, Alexander

Published
2024
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5. Ask2Me VarHarmonizer: A Python-Based Tool to Harmonize Variants from Cancer Genetic Testing Reports and Map them to the ClinVar Database

Author

Liu, Yuxi, Yin, Kanhua, Lamichhane, Basanta, Sandbach, John F., Patel, Gayle, Compagnoni, Gia, Kanak, Richard H., Rosen, Barry, Ondrula, David P., Smith, Linda, Brown, Eric, Gold, Linsey, Whitworth, Pat, App, Colleen, Euhus, David, Semine, Alan, Lyons, S. Dwight, Lazarte, Melford Allan C., Parmigiani, Giovanni, Braun, Danielle, and Hughes, Kevin S.

Subjects
Quantitative Biology - Quantitative Methods, Quantitative Biology - Genomics
Abstract

PURPOSE: The popularity of germline genetic panel testing has led to a vast accumulation of variant-level data. Variant names are not always consistent across laboratories and not easily mappable to public variant databases such as ClinVar. A tool that can automate the process of variants harmonization and mapping is needed to help clinicians ensure their variant interpretations are accurate. METHODS: We present a Python-based tool, Ask2Me VarHarmonizer, that incorporates data cleaning, name harmonization, and a four-attempt mapping to ClinVar procedure. We applied this tool to map variants from a pilot dataset collected from 11 clinical practices. Mapping results were evaluated with and without the transcript information. RESULTS: Using Ask2Me VarHarmonizer, 4728 out of 6027 variant entries (78%) were successfully mapped to ClinVar, corresponding to 3699 mappable unique variants. With the addition of 1099 unique unmappable variants, a total of 4798 unique variants were eventually identified. 427 (9%) of these had multiple names, of which 343 (7%) had multiple names within-practice. 99% mapping consistency was observed with and without transcript information. CONCLUSION: Ask2Me VarHarmonizer aggregates and structures variant data, harmonizes names, and maps variants to ClinVar. Performing harmonization removes the ambiguity and redundancy of variants from different sources.

Published
2019

9. Combined 70- and 80-gene signatures identify tumors with genomically luminal biology responsive to neoadjuvant endocrine therapy and are prognostic of 5-year outcome in early-stage breast cancer

Author

Pellicane, James V., Beitsch, Peter D., Rock, David T., Budway, Raye J., Dul, Carrie L., Kelemen, Pond R., Ashikari, Andrew Y., Baron, Paul L., Weinstein, Paul D., Mislowsky, Angela, Lee, Laura A., Beatty, Jennifer, Murray, Mary K., Dupree, Beth B., Finn, Christine, Corcoran, Kate, Wang, Shiyu, Menicucci, Andrea R., Yoder, Erin B., Blumencranz, Lisa E., Dauer, Patricia, Audeh, William, and Whitworth, Pat W.

Published
2022
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11. Age-Independent Preoperative Chemosensitivity and 5-Year Outcome Determined by Combined 70- and 80-Gene Signature in a Prospective Trial in Early-Stage Breast Cancer

Author

Whitworth, Pat, Beitsch, Peter D., Pellicane, James V., Baron, Paul L., Lee, Laura A., Dul, Carrie L., Nash, III, Charles H., Murray, Mary K., Richards, Paul D., Gittleman, Mark, Budway, Raye, Rahman, Rakhshanda Layeequr, Kelemen, Pond, Dooley, William C., Rock, David T., Cowan, Ken, Lesnikoski, Beth-Ann, Barone, Julie L., Ashikari, Andrew Y., Dupree, Beth, Wang, Shiyu, Menicucci, Andrea R., Yoder, Erin B., Finn, Christine, Corcoran, Kate, Blumencranz, Lisa E., and Audeh, William

Published
2022
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12. Neoadjuvant Chemotherapy for T3 Tumors in the Era of Precision Medicine—Biology Is Still King.

Author

Rahman, Rakhshanda Layeequr, Santillan, Alfredo, Habibi, Mehran, Beitsch, Peter, Whitworth, Pat, Ramaswamy, Harshini, Chmielewski-Stivers, Nicole, Menicucci, Andrea, Audeh, William, and O'Shaughnessy, Joyce

Subjects
NEOADJUVANT chemotherapy, ODDS ratio, BREAST cancer, ONCOLOGY, CANCER chemotherapy, BREAST
Abstract

Clinical T3 (cT3) breast cancer (BC) presents a challenge for achieving cosmetically acceptable breast conservation, and neoadjuvant chemotherapy (NAC) is commonly used for cytoreduction in these high-risk cancers. MammaPrint® risk-of-recurrence and BluePrint® molecular subtyping genomic signatures have demonstrated high accuracy in predicting chemotherapy benefits. Here, we examined the utility of MammaPrint/BluePrint for predicting pathological Complete Response (pCR) rates to NAC among 404 patients diagnosed with cT3 early-stage BC. The association of genomic subtype and clinical features with the likelihood of pCR was evaluated by multivariate logistic regression. Differences in pCR rates between genomic risk categories were evaluated by a two-sided proportional z-test and stratified by nodal status. MammaPrint/BluePrint subtyping was associated with significantly higher odds ratios (ORs) for pCR in MammaPrint High-Risk/BluePrint Basal-Type (OR = 3.06, 95% CI: 1.15–8.19, p = 0.025) and HER2-Type (OR = 6.27, 95% CI: 2.19–19.38, p = 0.001) compared to BluePrint Luminal-Type. Of the 209 patients with hormone receptor-positive, HER2-negative disease, 6.7% achieved pCR, and MammaPrint High-Risk was associated with a significantly higher pCR rate (9.3%) compared to MammaPrint Low-Risk cancers (0%), regardless of nodal involvement (p = 0.036). These data show that for patients with MammaPrint Low-Risk, cT3 tumors are less likely to have clinically impactful cytoreduction from NAC, regardless of nodal involvement. [ABSTRACT FROM AUTHOR]

Published
2025
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13. Identification of patients with DCIS with low-risk clinicopathology who benefit from radiation therapy with and without endocrine therapy after breast-conserving surgery assessed with the 7-gene biosignature.

Author

Whitworth, Pat W., primary, Shah, Chirag, additional, Vicini, Frank, additional, Rabinovitch, Rachel, additional, Margenthaler, Julie A., additional, Warnberg, Fredrik, additional, Leo, Michael C., additional, Weinmann, Sheila, additional, Mann, Bruce, additional, Dabbs, David J., additional, Savala, Jess, additional, Shivers, Steven C., additional, Mittal, Karuna, additional, and Bremer, Troy, additional

Published
2024
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14. Ki67 Proliferation Index as a Tool for Chemotherapy Decisions During and After Neoadjuvant Aromatase Inhibitor Treatment of Breast Cancer: Results From the American College of Surgeons Oncology Group Z1031 Trial (Alliance)

Author

Ellis, Matthew J, Suman, Vera J, Hoog, Jeremy, Goncalves, Rodrigo, Sanati, Souzan, Creighton, Chad J, DeSchryver, Katherine, Crouch, Erika, Brink, Amy, Watson, Mark, Luo, Jingqin, Tao, Yu, Barnes, Michael, Dowsett, Mitchell, Budd, G Thomas, Winer, Eric, Silverman, Paula, Esserman, Laura, Carey, Lisa, X., Cynthia, Unzeitig, Gary, Pluard, Timothy, Whitworth, Pat, Babiera, Gildy, Guenther, J Michael, Dayao, Zoneddy, Ota, David, Leitch, Marilyn, Olson, John A, Allred, D Craig, and Hunt, Kelly

Subjects
Cancer, Aging, Estrogen, Clinical Trials and Supportive Activities, Clinical Research, Breast Cancer, Development of treatments and therapeutic interventions, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, 5.1 Pharmaceuticals, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Aged, Anastrozole, Androstadienes, Antineoplastic Combined Chemotherapy Protocols, Aromatase Inhibitors, Breast Neoplasms, Clinical Decision-Making, Female, Follow-Up Studies, Humans, Ki-67 Antigen, Letrozole, Middle Aged, Mitotic Index, Neoadjuvant Therapy, Neoplasm Metastasis, Neoplasm Recurrence, Local, Neoplasm Staging, Nitriles, Predictive Value of Tests, Prognosis, Proportional Hazards Models, Receptors, Estrogen, Receptors, Progesterone, Survival Rate, Transcriptome, Triazoles, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Purpose To determine the pathologic complete response (pCR) rate in estrogen receptor (ER) -positive primary breast cancer triaged to chemotherapy when the protein encoded by the MKI67 gene (Ki67) level was > 10% after 2 to 4 weeks of neoadjuvant aromatase inhibitor (AI) therapy. A second objective was to examine risk of relapse using the Ki67-based Preoperative Endocrine Prognostic Index (PEPI). Methods The American College of Surgeons Oncology Group (ACOSOG) Z1031A trial enrolled postmenopausal women with stage II or III ER-positive (Allred score, 6 to 8) breast cancer whose treatment was randomly assigned to neoadjuvant AI therapy with anastrozole, exemestane, or letrozole. For the trial ACOSOG Z1031B, the protocol was amended to include a tumor Ki67 determination after 2 to 4 weeks of AI. If the Ki67 was > 10%, patients were switched to neoadjuvant chemotherapy. A pCR rate of > 20% was the predefined efficacy threshold. In patients who completed neoadjuvant AI, stratified Cox modeling was used to assess whether time to recurrence differed by PEPI = 0 score (T1 or T2, N0, Ki67 < 2.7%, ER Allred > 2) versus PEPI > 0 disease. Results Only two of the 35 patients in ACOSOG Z1031B who were switched to neoadjuvant chemotherapy experienced a pCR (5.7%; 95% CI, 0.7% to 19.1%). After 5.5 years of median follow-up, four (3.7%) of the 109 patients with a PEPI = 0 score relapsed versus 49 (14.4%) of 341 of patients with PEPI > 0 (recurrence hazard ratio [PEPI = 0 v PEPI > 0], 0.27; P = .014; 95% CI, 0.092 to 0.764). Conclusion Chemotherapy efficacy was lower than expected in ER-positive tumors exhibiting AI-resistant proliferation. The optimal therapy for these patients should be further investigated. For patients with PEPI = 0 disease, the relapse risk over 5 years was only 3.6% without chemotherapy, supporting the study of adjuvant endocrine monotherapy in this group. These Ki67 and PEPI triage approaches are being definitively studied in the ALTERNATE trial (Alternate Approaches for Clinical Stage II or III Estrogen Receptor Positive Breast Cancer Neoadjuvant Treatment in Postmenopausal Women: A Phase III Study; clinical trial information: NCT01953588).

Published
2017

15. The Clinical Utility of DCISionRT® on Radiation Therapy Decision Making in Patients with Ductal Carcinoma In Situ Following Breast-Conserving Surgery

Author

Shah, Chirag, Bremer, Troy, Cox, Charles, Whitworth, Pat, Patel, Rakesh, Patel, Anushka, Brown, Eric, Gold, Linsey, Rock, David, Riley, Lee, Kesslering, Christy, Brown, Sheree, Gabordi, Robert, Pellicane, James, Rabinovich, Rachel, Khan, Sadia, Templeton, Sandra, Majithia, Lonika, Willey, Shawna C., Wärnberg, Fredrik, Gerber, Naamit K., Shivers, Steve, and Vicini, Frank A.

Published
2021
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16. The Clinical Utility of a 7-Gene Biosignature on Radiation Therapy Decision Making in Patients with Ductal Carcinoma In Situ Following Breast-Conserving Surgery: An Updated Analysis of the DCISionRT® PREDICT Study.

Author

Shah, Chirag, Whitworth, Pat, Vicini, Frank A., Narod, Steven, Gerber, Naamit, Jhawar, Sachin R., King, Tari A., Mittendorf, Elizabeth A., Willey, Shawna C., Rabinovich, Rachel, Gold, Linsey, Brown, Eric, Patel, Anushka, Vargo, John, Barry, Parul N., Rock, David, Friedman, Neil, Bedi, Gauri, Templeton, Sandra, and Brown, Sheree

Abstract

Background: Breast-conserving surgery (BCS) followed by adjuvant radiotherapy (RT) is a standard treatment for ductal carcinoma in situ (DCIS). A low-risk patient subset that does not benefit from RT has not yet been clearly identified. The DCISionRT test provides a clinically validated decision score (DS), which is prognostic of 10-year in-breast recurrence rates (invasive and non-invasive) and is also predictive of RT benefit. This analysis presents final outcomes from the PREDICT prospective registry trial aiming to determine how often the DCISionRT test changes radiation treatment recommendations. Methods: Overall, 2496 patients were enrolled from February 2018 to January 2022 at 63 academic and community practice sites and received DCISionRT as part of their care plan. Treating physicians reported their treatment recommendations pre- and post-test as well as the patient's preference. The primary endpoint was to identify the percentage of patients where testing led to a change in RT recommendation. The impact of the test on RT treatment recommendation was physician specialty, treatment settings, individual clinical/pathological features and RTOG 9804 like criteria. Multivariate logisitc regression analysis was used to estimate the odds ratio (ORs) for factors associated with the post-test RT recommendations. Results: RT recommendation changed 38% of women, resulting in a 20% decrease in the overall recommendation of RT (p < 0.001). Of those women initially recommended no RT (n = 583), 31% were recommended RT post-test. The recommendation for RT post-test increased with increasing DS, from 29% to 66% to 91% for DS <2, DS 2–4, and DS >4, respectively. On multivariable analysis, DS had the strongest influence on final RT recommendation (odds ratio 22.2, 95% confidence interval 16.3–30.7), which was eightfold greater than clinicopathologic features. Furthermore, there was an overall change in the recommendation to receive RT in 42% of those patients meeting RTOG 9804-like low-risk criteria. Conclusions: The test results provided information that changes treatment recommendations both for and against RT use in large population of women with DCIS treated in a variety of clinical settings. Overall, clinicians changed their recommendations to include or omit RT for 38% of women based on the test results. Based on published clinical validations and the results from current study, DCISionRT may aid in preventing the over- and undertreatment of clinicopathological 'low-risk' and 'high-risk' DCIS patients. Trial Registration: ClinicalTrials.gov identifier: NCT03448926 (https://clinicaltrials.gov/study/NCT03448926). [ABSTRACT FROM AUTHOR]

Published
2024
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18. Legacy Genetic Testing Results for Cancer Susceptibility: How Common are Conflicting Classifications in a Large Variant Dataset from Multiple Practices?

Author

Yin, Kanhua, Liu, Yuxi, Lamichhane, Basanta, Sandbach, John F., Patel, Gayle, Compagnoni, Gia, Kanak, Richard H., Rosen, Barry, Ondrula, David P., Smith, Linda, Brown, Eric, Gold, Linsey, Whitworth, Pat, App, Colleen, Euhus, David, Semine, Alan, Dwight Lyons, S., Lazarte, Melford Allan C., Parmigiani, Giovanni, Braun, Danielle, and Hughes, Kevin S.

Published
2020
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19. ASO Visual Abstract: Age-Independent Preoperative Chemosensitivity and 5-Year Outcome Determined by Combined 70- and 80-Gene Signature in a Prospective Trial in Early-Stage Breast Cancer

Author

Whitworth, Pat, Beitsch, Peter D., Pellicane, James V., Baron, Paul L., Lee, Laura A., Dul, Carrie L., Nash, III, Charles H., Murray, Mary K., Richards, Paul D., Gittleman, Mark, Budway, Raye, Layeequr Rahman, Rakhshanda, Kelemen, Pond, Dooley, William C., Rock, David T., Cowan, Ken H., Lesnikoski, Beth-Ann, Barone, Julie L., Ashikari, Andrew Y., Dupree, Beth, Wang, Shiyu, Menicucci, Andrea R., Yoder, Erin B., Finn, Christine, Corcoran, Kate, Blumencranz, Lisa E., and Audeh, William

Published
2022
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20. Distinct Neoadjuvant Chemotherapy Response and 5-Year Outcome in Patients With Estrogen Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Breast Tumors That Reclassify as Basal-Type by the 80-Gene Signature

Author

Whitworth, Pat W., Beitsch, Peter D., Pellicane, James V., Baron, Paul L., Lee, Laura A., Dul, Carrie L., Murray, Mary K., Gittleman, Mark A., Budway, Raye J., Rahman, Rakhshanda Layeequr, Kelemen, Pond R., Dooley, William C., Rock, David T., Cowan, Kenneth H., Lesnikoski, Beth-Ann, Barone, Julie L., Ashikari, Andrew Y., Dupree, Beth B., Wang, Shiyu, Menicucci, Andrea R., Yoder, Erin B., Finn, Christine, Corcoran, Kate, Blumencranz, Lisa E., and Audeh, William

Published
2022
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21. Development and Validation of a Breast Cancer Polygenic Risk Score on the Basis of Genetic Ancestry Composition

Author

Hughes, Elisha, Wagner, Susanne, Pruss, Dmitry, Bernhisel, Ryan, Probst, Braden, Abkevich, Victor, Simmons, Timothy, Hullinger, Brooke, Judkins, Thaddeus, Rosenthal, Eric, Roa, Benjamin, Domchek, Susan M., Eng, Charis, Garber, Judy, Gary, Monique, Klemp, Jennifer, Mukherjee, Semanti, Offit, Kenneth, Olopade, Olufunmilayo I., Vijai, Joseph, Weitzel, Jeffrey N., Whitworth, Pat, Yehia, Lamis, Gordon, Ora, Pederson, Holly, Kurian, Allison, Slavin, Thomas P., Gutin, Alexander, and Lanchbury, Jerry S.

Published
2022
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22. Genomic Classification of HER2-Positive Patients With 80-Gene and 70-Gene Signatures Identifies Diversity in Clinical Outcomes With HER2-Targeted Neoadjuvant Therapy

Author

Whitworth, Pat W., Beitsch, Peter D., Murray, Mary K., Richards, Paul D., Mislowsky, Angela, Dul, Carrie L., Pellicane, James V., Baron, Paul L., Rahman, Rakhshanda Layeequr, Lee, Laura A., Dupree, Beth B., Kelemen, Pond R., Ashikari, Andrew Y., Budway, Raye J., Lopez-Penalver, Cristina, Dooley, William, Wang, Shiyu, Dauer, Patricia, Menicucci, Andrea R., Yoder, Erin B., Finn, Christine, Blumencranz, Lisa E., and Audeh, William

Published
2022
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24. The integrals in Gradshteyn and Ryzhik. Part9: Combinations of logarithms, rational and trigonometric functions

Author

Amdeberhan, Tewodros, Moll, Victor H., Rosenberg, Jason, Straub, Armin, and Whitworth, Pat

Subjects
Mathematics - Classical Analysis and ODEs, 33B10
Abstract

The classical table of integrals by I. S. Gradshteyn and I. M. Ryzhik contains many definite integrals where the integrand is the product of a rational function times the logarithm of another rational function. We begin the systematic evaluation of these integrals., Comment: 16 pages

Published
2007

27. Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Harvey, Vernon, Tomek, Rudolf, Robert, Nicholas J., Gore, Ira, Jr., Smith, John W., II, Masuda, Norikazu, Di Sean Kendall, S., Harker, William Graydon, Petrakova, Katarina, Guerrero Zotano, Angel, Simon, Amparo Ruiz, Konstantinovic, Zora Neskovic, Iannotti, Nicholas O., Tassone, Pierfrancesco, Rodriguez, Gladys I., Jáñez Martinez, Noelia, Crespo Massieu, Carmen, Smickoska, Snezana, Somali, Isil, Yilmaz, Ugur, Alonso, Mirta Garcia, Rosales, Adolfo Murias, Cold, Soeren, Knoop, Ann Soegaard, Patt, Debra, Hellerstedt, Beth A., Morales Murillo, Serafin, Mayer, Ingrid A., Means-Powell, Julie Ann, Hui, Rina, Senecal, Francis M., De Boer, Richard Hendry, Shen, Zhenzhou, Luczak, Adam Andrzej, Chui, Joanna W.Y., Tsang, Janice Wing-hang, Lang, Istvan, Rai, Yoshiaki, Hozumi, Yasuo, Ten Tije, Albert J., Bhandari, Manish, Osborne, Cynthia R.C., Ohtani, Shoichiro, Higaki, Kenji, Watanabe, Kenichi, Taguchi, Kazunori, Takahashi, Masato, Filipovic, Sladjana, Hansen, Vincent L., Rao, Vijayarama Phooshkooru, Gupta, Manish, Petrov, Petar, Coudert, Bruno, Vojnovic, Zeljko, Polya, Zsofia, Miyaki, Toshiko, Yamamoto, Naohito, Brincat, Stephen, Lesniewski-Kmak, Krzysztof, Chmielowska, Ewa, Birhiray, Ruemu E., Citron, Marc L., Papish, Steven William, Berry, William R., Langkjer, Sven Tyge, Garcia Sáenz, José Angel, Arance, Ana Maria, Efrat, Noa, Sarosiek, Tomasz, Grzeda, Lukasz, Manalo, Yvonne, Smith, Julie C., Vaziri, Irfan, Healey, Tabitha, Rahim, Yasmin, Luk, Cynthia, Dingle, Brian, Franco, Sandra, Sorensen, Peter Grundtvig, Anand, Anjana, Khan, Sarah, Fountzilas, George, Aogi, Kenjiro, Shimizu, Satoru, Mikulova, Milada, Spanik, Stanislav, Somer, Robert A., Flynn, Patrick J., Coward, Jermaine, Mainwaring, Paul, Jerusalem, Guy, Segura-Ojezzar, Carine, Levy, Christelle, Delozier, Thierry, Khayat, David, Coleman, Robert E., Rolles, Martin J., Maisano, Robert, Nardi, Mario, Ito, Yoshinori, Yumuk, Perran Fulden, Basaran, Gul, Serdar Turhal, Nazim, Wilkinson, Mary J., Green, Nathan B., Sidrys, Algis P., Hallmeyer, Sigrun, Testori, Douglas J., Sridhar, Srikala, Chang, Jose, Sun, Qiang, Jara-Sanchez, Carlos, Rubio, Xabier, Garrido, Maria Lomas, De La Haba Rodriguez, Juan Rafael, Perello Martorell, Antonia, Avelia Mestre, Antoni, Rifa Ferrer, Julio, del Barco Berron, Sonia, Nagy, Zsuzsanna, Tanaka, Maki, Im, Young-Hyuck, Carroll, Robert R., Dickerson, Laura C., Mace, Joseph R., Rivera, Ragene, Klein, Leonard M., Ruxer, Robert, Wilks, Sharon T., Kotasek, Dusan, Popov, Vasil, Taskova, Violina, Marinova-Venkova, Violetka, Timcheva, Constanta, Desbiens, Christine, Ayoub, Jean-Pierre, Grenier, Debjani, Marschner, Norbert, Tesch, Hans, Lueck, Hans-Joachim, Janssen, Jan, Schwaner, Ingo, Wahlstrom, Stine, Brix, Eva Harder, Vallentin, Susanne, Kristensen, Dan, Andreeva, Anna, Glavicic, Vesna, Calvo Plaza, Isabel, Anton Torres, Antonio, Veyret, Corinne, Bergerat, Jean-Pierre, Bourbouloux, Emmanuelle, Ella, Wendy Ann, Algurafi, Hafiz, Robinson, Anne, Kim, Seung Jin, Taguchi, Tetsuya, Juozaityte, Elona, Madretsma, Stanley, Radema, Sandra, Czerniawska-Meier, Malgorzata, Rogowski, Wojciech, Wagnerova, Maria, Richards, Donald A., Tan-Chiu, Elizabeth, Vasileios, Asskikis, Henderson, Charles Arthur, Holden, Viran Roger, Wang, Xiaojia, Tong, Zhongsheng, Yang, Junlan, Gonzalez, Manuel Enrique, Rezai, Mahdi, Hackmann, John, de Dueñas, Eduardo Martinez, de las Heras, Begoña Bermejo, Dourthe, Louis Marie, Chocteau-Bouju, Dorothee, Bougnoux, Philippe, Kakolyris, Stylianos, Kalofonos, Haralabos, Pectasidis, Dimitrios, Ng, Ting Ying, Pajkos, Gabor, Somogyine, Eva Ezer, Tonini, Giuseppe, Giuffrida, Dario, Takao, Shintaro, Ishitobi, Makoto, Inaji, Hideo, Tokuda, Yutaka, Wozniak, Katarzyna, Lungulescu, Dan, Lu, Yen-Shen, Chang, King-Jen, Hill, Julian, Croot, Christopher Charles, Dekker, Albert, Belman, Neil D., Conde, Miguel, Michaelson, Richard A., Kemmer, Kathleen, Chui, Stephen, Luoh, Shiuh-Wen, Nahum, Kenneth, Greenspan, Andrew R., Nichols, Joni C., Encarnacion, Carlos A., Niederman, Thomas M.J., Lee, Theresa, Alexander, Roland, Gordon, Robert, Tomova, Antoanet, Rauch, Daniel, Popescu, Razvan Andrei, Rojas, Gustavo Adolfo, Vanasek, Jaroslav, Neunhoeffer, Tanja, Barinoff, Jana, Graffunder, Gerd, Wolfgang, Abenhardt, Bojko, Peter, Heinrich, Bernhard, von der Assen, Albert, Antonovic, Bogovic Jurij, Adrian, Lene, Ramos Vazquez, Manuel, Gonzalez Santiago, Santiago, Dieras, Veronique, Bishop, Jill Mercia, Perren, Timothy John, Varthalitis, Ioannis, Mavroudis, Dimitris, Georgoulias, Vassilis, Chow, Louis W.C., Yau, Chung Cheung Thomas, Liang, Raymond Hin-Suen, Pikó, Béla, Wéber, Agnes, Kaufman, Bella, Drumea, Karen, Nuzzo, Francesco, De Matteis, Andrea, Carteni, Giacomo, Tokunaga, Eriko, Ishida, Mayumi, Ohno, Shinji, Sato, Nobuaki, Kuroi, Katsumasa, Nishimura, Reiki, Watanabe, Junichiro, Choi, Yoon Ji, Park, Kyong Hwa, Wojtukiewicz, Marek, Jassem, Jacek, Loman, Niklas, Askoy, Sercan, Altundag, Mustafa Kadri, Saip, Pinar, Ali, Muhammad Amjad, Wade, James Lloyd, III, Chien, Amy Jo, Brandt, Debra, Novik, Yelena, Jani, Chirag, Rice, Robert L., Gaffar, Yousuf A. R, Keaton, Mark R., Bajaj, Rajesh, Kimmick, Gretchen, Campbell, David, Turnquest, Theodore, Lucas, Sideras, Dube, Pierre, Xu, Binghe, Schilling, Joerg, Apel, Klaus, Vestlev, Peter Michael, Jensen, Brita Bjerregaard, Haahr, Vera, Lescure, Alvaro Rodriguez, Grana Suarez, Begona, Saura Manich, Cristina, Jacquin, Jean-Philippe, Samreen, Ahmed, Boiangiu, Ion, Dank, Magdolna, Falci, Cristina, Jirillo, Antonio, Cinieri, Saverio, Ueno, Takayuki, Sato, Fumiaki, Yamashiro, Hiroyasu, Sugie, Tomoharu, Lee, Keun Seok, Ro, Jung Sil, Park, In Hae, Bustam, Anita Zarina, Suszko-Kazarnowicz, Malgorzata, Piktel, Artur, Krzemieniecki, Krzysztof, Iorga, Polizenia Georgeta, Yap, Yoon Sim, Kakalejcik, Marian, Sevinc, Alper, Ozguroglu, Mustafa, Chen, Shin-Cheh, Greenberg, Richard H., Eisemann, Allan Daniel, Droder, Robert, Abbasi, M. Rashid, Vaysburd, Marina, Caldera, Humberto Jose, Haley, Barbara Bacsik, Robin, Erwin, Inhorn, Roger C., Hufnagel, David, Kenyon, Peter D., Spremulli, Ellen, Silverman, Paula, Jain, Sharad, Weigand, Robert, Mebis, Jeroen, Koynova, Tatyana, Lesperance, Bernard, Prausova, Jana, Kohne, Claus-Henning, Schneeweiss, Andreas, Jackisch, Christian, Fuxius, Stefan, Cubedo Cervera, Ricardo, Urruticoechea Ribate, Ander, Pernas Simon, Sonia, Valero Gallego, Jose, Arcusa Lanza, Angels, del Pilar Alvarez, Maria, Florian Gerico, Jesus, Cany, Laurent, Stebbing, Justin, Labudovic, Dejan, Gugic, Damir, Vrbanec, Damir, Roila, Fausto, Barni, Sandro, Bidoli, Paolo, Mukai, Hirofumi, Bermudez, Vanessa, Eniu, Alexandru, Mirtsching, Barry C., Ibrahim, Emad, Trey, Joan, Hergenroeder, Paul Francis, Mahmood, Aftab, Gonzalez, Anneliese, Kaplan, Edward H., Ban, Stacy, Patel, Dhimant, Clowney, Billy, Hoelzer, Karen, Schwartz, Garry H., Salkeni, Mohamed, Abraham, Jame, Narula, Sunil, Jabboury, Khaled, Mocharnuk, Robert Scott, McDonough, Richard H., Sikes, David H., Kawanchi, Ronald H., Schlabach, Larry, McCachren, Samuel Spence, Jr., Cosgriff, Thomas M., Dreisbach, Luke, DeMichele, Angela, Pawl, Lawrence, Lucas, Jennifer, Shinn, Lowell C., Alkhouri, Nabiel, Monga, Manish, Lindquist, Deborah L., Anderson, Thomas C., Khurshid, Humera, Witherby, Sabrina, Erickson, Nicholette, Traynor, Ann, Bose, Ron, Pluard, Timothy J., Jones, Michael C., Prakash, Sucharu, Volterra, Fabio, Capo, Gerardo, Flaherty, Lawrence E., Gartner, Elaina, Baidas, Said, Okazaki, Ian, Nguyen, Bichlien, Rakowski, Thomas, Oliff, Ira, Leach, Joseph W., Anderson, Daniel, Kubiak, Kendra, Tsai, Michaela, Vroman, Philippe, Deleu, Ines, Lybaert, Willem, Borms, Marleen, Couture, Felix, Wilson, Jonathan J., Hunt, Gordon, Holland, David R., Mingrone, Walter, Wang, Shusen, Liu, Donggeng, Jiang, Zefei, Benesova, Vera, Smakal, Martin, Garnolova, Petra, Vesper, Anne-Sophie, Neumann, Monika, Janni, Wolfgang, Liedtke, Cornelia, Fischer, Dorothea, Grischke, Eva-Maria, Seeger, Dietmar, Moebus, Volker, Prechtl, Anita, Carlos Camara Toral, Juan, Sanchez Munoz, Alfonso, Gonzalez Jimenez, Sonia, Cassinello Espinosa, Javier, Cirauqui, Beatriz, Margeli Vila, Mireia, Batista Lopez, Norberto, Chacon Lopez-Muniz, Jose Ignacio, de la Cruz Mora, Miguel Angel, Mailliez, Audrey, Vanlemmens, Laurence, Pouessel, Damien, Espie, Marc, Conibear, John, Roylance, Rebecca, Harnett, Adrian, Geffen, David, Ruggeri, Enzo Maria, Gamucci, Teresa, Van Groeningen, Cees J., Banas, Renata, Alkis, Necati, Hou, Ming-Feng, Krie, Amy K., Vrindavanam, Nandagopal S., Howard, Orion M., Citrin, Dennis, Morginstin, Mark S., Desai, Ajit, Sanchez, Ines J., Nixon, David Allen, Jr., Beatty, Patrick G., Edmiston, Kathryn, McLaughlin, Marilyn, Eneman, Jonathan D., Lynch, Cynthia A., O'Brien, Edward, Call, Justin A., Lanier, Keith S., Conlin, Alison, Brooks, Donald J., McIntyre, Kristi, Saltzman, Marc A., Castine, Michael J., III, Ortega, Gregory L., Choi, Young M., Reynolds, Craig H., Brescia, Frankie Ann, Kramer, Rita, Kohn, Aimee D., Micha, John P., Rhee, Jessica M., Shah, Satish, Riseberg, David A., Patterson, William Kevin, Salmon, Jean-Paul, Andre, Chantal, Bols, Alain, D'hondt, Randal, Luce, Sylvie, Nouwynck, Claire, Pelgrims, Gino, Richard, Vincent, Verschuere, Johan, Geldhof, Kurt, Caspar, Clemens, Luo, Rongcheng, Bednarik, Otakar, Schwedler, Kathrin, Schmidt, Marcus, Neumeister, Romy, Bischoff, Joachim, Rack, Brigitte, Repp, Roland, Fries, Stefan, Adrion, Ralf, Schulz, Volker, Klare, Peter, Danei, Mahmoud, Ossenbuhl, Dirk, Kusche, Jakob Manfred, Griesinger, Frank, Baena Canada, Jose Manuel, Martinez del Prado, Purificacion, Machover, David, Mayeur, Didier, Trufflandier, Nathalie, Delecroix, Valerie, Mousseau, Mireille, Mouret-Reynier, Marie-Ange, Nabholtz, Jean-Marc, Chetiyawardana, Anula D., Papandreou, Christos, Hornyak, Lajos, Faluhelyi, Zsolt, Simo, Erzsebet, Di Palma, Mario, Cognetti, Francesco, Gorzegno, Gabriella, Dogliotti, Luigi, Gridelli, Cesare, Falcone, Alfredo, Soto Parra, Hector, Buscarino, Calogero, Im, Seock-Ah, Sanchez Llamas, Benito, Dercksen, Wouter, Erdkamp, Franciscus, Ruit, Jan B., Braun, Hans, Portielje, Joanneke E.A., Ciltas, Aydin, Buyukberber, Suleyman, Benekli, Mustafa, Zahalsky, Andrew J., Jaslow, Rebecca, Thomas, Gary W., Maini, Archana, Wiznitzer, Israel, Khojasteh, Ali, Francisco Gonzalez, Manuel, Kong, Lynn R., Padmanabhan, Aruna, Conkright, William A., Swain, Sandra M., Faig, Douglas E., Jain, Kirti, Yanagihara, Ronald H., Ottaviano, Yvonne, Delmas, Andrew, Steele, Heather A., Rainey, Gordon K., Harris, Penelope J., Burris, Jason K., Rupard, Erik J., Tan, Esther, Whitworth, Pat W., Bova, Abby R., Anderson, Ian C., Shirinian, Mihran, Tin-u, Caesar, O'Rourke, Timothy J., Roberts, Michael S., Francisco, Michael, Pierson, A. Scott, Byeff, Peter D., Kovach, Peter A., Caton, John R., Jr., Rarick, Mark Urban, Schimidt, William G., Jr., Stopeck, Alison T., Swart, Rachel, Carrillo Flores, Maria Regina, Alemany, Carlos A., Lozada, Brennely, Weinstein, Paul L., Wang, Wei, Porubcin, Michael, Ellison, David M., Geils, George F., Rivera, Edgardo, Charif, Mahmoud, Martin, Miguel, Holmes, Frankie A, Ejlertsen, Bent, Delaloge, Suzette, Moy, Beverly, Iwata, Hiroji, von Minckwitz, Gunter, Chia, Stephen K L, Mansi, Janine, Barrios, Carlos H, Gnant, Michael, Tomašević, Zorica, Denduluri, Neelima, Šeparović, Robert, Gokmen, Erhan, Bashford, Anna, Ruiz Borrego, Manuel, Kim, Sung-Bae, Jakobsen, Erik Hugger, Ciceniene, Audrone, Inoue, Kenichi, Overkamp, Friedrich, Heijns, Joan B, Armstrong, Anne C, Link, John S, Joy, Anil Abraham, Bryce, Richard, Wong, Alvin, Moran, Susan, Yao, Bin, Xu, Feng, Auerbach, Alan, Buyse, Marc, and Chan, Arlene

Published
2017
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28. Correction to: The Clinical Utility of DCISionRT® on Radiation Therapy Decision Making in Patients with Ductal Carcinoma In Situ Following Breast-Conserving Surgery

Author

Shah, Chirag, Bremer, Troy, Cox, Charles, Whitworth, Pat, Patel, Rakesh, Patel, Anushka, Brown, Eric, Gold, Linsey, Rock, David, Riley, Lee, Kesslering, Christy, Brown, Sheree, Gabordi, Robert, Pellicane, James, Rabinovich, Rachel, Khan, Sadia, Templeton, Sandra, Majithia, Lonika, Willey, Shawna C., Wärnberg, Fredrik, Gerber, Naamit K., Shivers, Steve, and Vicini, Frank A.

Published
2021
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32. Table S1 from Validation of a Ductal Carcinoma In Situ Biomarker Profile for Risk of Recurrence after Breast-Conserving Surgery with and without Radiotherapy

Author

Weinmann, Sheila, primary, Leo, Michael C., primary, Francisco, Melanie, primary, Jenkins, Charisma L., primary, Barry, Todd, primary, Leesman, Glen, primary, Linke, Steven P., primary, Whitworth, Pat W., primary, Patel, Rakesh, primary, Pellicane, James, primary, Wärnberg, Fredrik, primary, and Bremer, Troy, primary

Published
2023
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34. Supplemental Material from A Biological Signature for Breast Ductal Carcinoma In Situ to Predict Radiotherapy Benefit and Assess Recurrence Risk

Author

Bremer, Troy, primary, Whitworth, Pat W., primary, Patel, Rakesh, primary, Savala, Jess, primary, Barry, Todd, primary, Lyle, Stephen, primary, Leesman, Glen, primary, Linke, Steven P., primary, Jirström, Karin, primary, Zhou, Wenjing, primary, Amini, Rose-Marie, primary, and Wärnberg, Fredrik, primary

Published
2023
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35. Abstract P3-05-43: Germline Testing Results in Patients with Genomic Tumor Profiling

Author

Beitsch, Peter, primary, Wernecke, Chloe, additional, Patel, Rakesh, additional, Rosen, Barry, additional, Brown, Eric, additional, Compagnoni, Gia, additional, Grady, Ian, additional, Gold, Lindsay, additional, Whitworth, Pat, additional, Smith, Linda Ann, additional, Wirga, Mariusz, additional, Reitherman, Richard, additional, Cai, Steven, additional, Nguyen, Toan, additional, Traina, Valerie, additional, Holmes, Dennis, additional, Baron, Paul, additional, Krautheim, Brittany, additional, Peled, Anne, additional, Taylor, Walt, additional, Bontempo, Kelly, additional, Bentley, Brenna, additional, Ortega, Krista, additional, and Ahmadi, Pouyan, additional

Published
2023
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37. Abstract P6-02-09: Racial/Ethnic Groups Have Different Rates of Pathogenic Variants in Common Cancer Genes

Author

Beitsch, Peter, primary, Wernecke, Chloe, additional, Patel, Rakesh, additional, Rosen, Barry, additional, Compagnoni, Gia, additional, Grady, Ian, additional, Brown, Eric, additional, Gold, Lindsay, additional, Whitworth, Pat, additional, Smith, Linda Ann, additional, Wirga, Mariusz, additional, Reitherman, Richard, additional, Cai, Steven, additional, Nguyen, Toan, additional, Traina, Valerie, additional, Holmes, Dennis, additional, Baron, Paul, additional, Krautheim, Brittany, additional, Peled, Anne, additional, Taylor, Walt, additional, Bontempo, Kelly, additional, Bentley, Brenna, additional, Ortega, Krista, additional, and Ahmadi, Pouyan, additional

Published
2023
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38. Abstract PD9-08: ImPrint immune signature in 10,000 early-stage breast cancer patients from the real-world FLEX database

Author

Brufsky, Adam M., primary, Kuilman, Midas, additional, Mukhtar, Rita, additional, Wolf, Denise M., additional, Yau, Christina, additional, O’Shaughnessy, Joyce, additional, Graham, Cathy, additional, Gadi, Vijayakrishna K., additional, Whitworth, Pat, additional, Hindenburg, Alexander, additional, Grady, Ian, additional, Srkalovic, Gordon, additional, Hoskins, Kent, additional, Dhakal, Ajay, additional, Ma, Cynthia, additional, Hunter, Natasha, additional, Crozier, Jennifer, additional, Mavromatis, Blanche, additional, Mittempergher, Lorenza, additional, Finn, Christine, additional, Modh, Shraddha, additional, Yoder, Erin B., additional, Dauer, Patricia, additional, Menicucci, Andrea, additional, van der Baan, Bas, additional, Audeh, William, additional, and Esserman, Laura J., additional

Published
2023
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39. Abstract P1-04-06: Characterization of recurrence risk after lumpectomy and radiotherapy in HER2-positive ductal carcinoma in situ of the breast, using 7-gene predictive biosignature: Implications for the NSABP-B43 trial results

Author

Vicini, Frank, primary, Shah, Chirag, additional, Rabinovitch, Rachel, additional, Whitworth, Pat, additional, Margenthaler, Julie A., additional, Czerniecki, Brian J., additional, DABBS, DAVID J., additional, Weinmann, Sheila, additional, Leo, Michael, additional, Mann, G Bruce, additional, Wärnberg, Fredrik, additional, Savala, jess, additional, Shivers, Steven C., additional, Mittal, Karuna, additional, and Bremer, Troy, additional

Published
2023
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41. Abstract PD14-05: PD14-05 Prospective longitudinal validation of a breast cancer risk prediction model in a cohort of 130,058 women

Author

Mabey, Brent, primary, Hughes, Elisha, additional, Probst, Braden, additional, Pederson, Holly J., additional, Simmons, Timothy, additional, Morris, Brian, additional, Hullinger, Brooke, additional, Domchek, Susan, additional, Eng, Charis, additional, Gary, Monique, additional, Klemp, Jennifer, additional, Mukherjee, Semanti, additional, Joseph, Vijai, additional, Offit, Kenneth, additional, Olopade, Olufunmilayo I., additional, Pruthi, Sandhya, additional, Kurian, Allison W., additional, Robson, Mark E., additional, Whitworth, Pat, additional, Wagner, Susanne, additional, Lanchbury, Jerry, additional, Slavin, Thomas, additional, and Gutin, Alexander, additional

Published
2023
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42. Abstract P3-05-44: Genomic testing and Ki-67 Percentage: Two puzzle pieces being undervalued in breast cancer treatment

Author

Wernecke, Chloe, primary, Ortega, Krista, additional, Bontempo, Kelly, additional, Bentley, Brenna, additional, Hoyer-Kimura, Christina, additional, Beitsch, Peter, additional, Patel, Rakesh, additional, Rosen, Barry, additional, Compagnoni, Gia, additional, Grady, Ian, additional, Brown, Eric, additional, Gold, Lindsay, additional, Whitworth, Pat, additional, Smith, Linda Ann, additional, Reitherman, Richard, additional, Wirga, Mariusz, additional, Cai, Steven, additional, Nguyen, Toan, additional, Traina, Valerie, additional, Holmes, Dennis, additional, Baron, Paul, additional, Krautheim, Brittany, additional, Peled, Anne, additional, and Taylor, Walt, additional

Published
2023
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43. Abstract PD15-07: PD15-07 7-gene predictive biosignature improves risk stratification for breast ductal carcinoma in situ patients compared to clinicopathologic criteria, identifying a low risk group not clinically benefiting from adjuvant radiotherapy

Author

Rabinovitch, Rachel, primary, Vicini, Frank, additional, Shah, Chirag, additional, Margenthaler, Julie A., additional, Czerniecki, Brian J., additional, Whitworth, Pat, additional, DABBS, DAVID J., additional, Mann, G Bruce, additional, Wärnberg, Fredrik, additional, Weinmann, Sheila, additional, Leo, Michael, additional, Savala, Jess, additional, Shivers, Steven C., additional, Mittal, Karuna, additional, and Bremer, Troy, additional

Published
2023
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45. A Novel Biosignature Identifies Patients With DCIS With High Risk of Local Recurrence After Breast Conserving Surgery and Radiation Therapy

Author

Vicini, Frank A., primary, Mann, G. Bruce, additional, Shah, Chirag, additional, Weinmann, Sheila, additional, Leo, Michael C., additional, Whitworth, Pat, additional, Rabinovitch, Rachel, additional, Torres, Mylin A., additional, Margenthaler, Julie A., additional, Dabbs, David, additional, Savala, Jess, additional, Shivers, Steven C., additional, Mittal, Karuna, additional, Wärnberg, Fredrik, additional, and Bremer, Troy, additional

Published
2023
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46. P063: Prospective longitudinal validation of a breast cancer risk prediction model in a cohort of 130,058 individuals*

Author

Mabey, Brent, primary, Hughes, Elisha, additional, Probst, Braden, additional, Pederson, Holly, additional, Simmons, Timothy, additional, Morris, Brian, additional, Hullinger, Brooke, additional, Domchek, Susan, additional, Eng, Charis, additional, Gary, Monique, additional, Klemp, Jennifer, additional, Mukherjee, Semanti, additional, Vijai, Joseph, additional, Offit, Kenneth, additional, Olopade, Olufunmilayo, additional, Pruthi, Sandhya, additional, Kurian, Allison, additional, Robson, Mark, additional, Whitworth, Pat, additional, Wagner, Susanne, additional, Lanchbury, Jerry, additional, Slavin, Thomas, additional, and Gutin, Alexander, additional

Published
2023
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48. Abstract B016: Guiding de-escalation of treatment for patients with DCIS using a predictive 7-gene biosignature: Identification of a clinically low-risk patient group

Author

Rabinovitch, Rachel, primary, Vicini, Frank A., additional, Shah, Chirag, additional, Margenthaler, Julie, additional, Czerniecki, Brian, additional, Whitworth, Pat, additional, Weinmann, Sheila, additional, Leo, Michael C., additional, Wärnberg, Fredrik, additional, Mann, G. Bruce, additional, Shivers, Steven C., additional, Dabbs, David, additional, Mittal, Karuna, additional, and Bremer, Troy, additional

Published
2022
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