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4 results on '"Whitney Beck"'

1. Increased Chemokine Production is a Hallmark of Rhesus Macaque Natural Killer Cells Mediating Robust Anti-HIV Envelope-Specific Antibody-Dependent Cell-Mediated Cytotoxicity

Author

Junsuke Nohara, Tyler Evangelous, Madison Berry, Whitney Beck, Sarah Mudrak, Shalini Jha, R. Keith Reeves, Kevin J. Wiehe, Justin Pollara, Georgia Tomaras, Todd Bradley, and Guido Ferrari

Subjects
Rhesus Macaque, NK cells, Antibody-Dependent Cell Cytotoxicity, Single-Cell Gene Expression Analysis, Chemokine, Pathology, RB1-214, Immunologic diseases. Allergy, RC581-607
Abstract

Background: Antibody-dependent cell-mediated cytotoxic (ADCC) response mediated by natural killer (NK) cells correlates with decreased infection risk in studies involving simian immunodeficiency virus (SIV)/simian-human immunodeficiency virus (SHIV), and human immunodeficiency virus (HIV) vaccine candidates. Currently, the heterogeneities of the functional subset of rhesus macaque natural killer (RMNK) cells are under-characterized. Method: We engaged the RMNK cells with ADCC-mediating anti-HIV-1 monoclonal antibodies (ADCCAbs) or anti-CD16 antibodies and used CD107a expression as the surrogate marker for RMNK cells actively involved in ADCC. CD107a+ and CD107a– populations were analyzed individually using single-cell RNA sequencing. Results: Subsets of CD107a+ RMNK cells produced more chemokines than the others, suggesting that these cells not only eliminate infected cells but also provide immunoregulatory signals and potentially curb HIV-1 replication. Crosslinking of Fc gamma receptor IIIa via anti-CD16 antibodies resulted in a significantly higher percentage of degranulating cells than via ADCCAbs. However, the magnitude of degranulation and chemokine production was reduced by 6- to 30-fold. Conclusion: The quality and quantity of receptor engagement are important determinants of achieving an optimal level of the RMNK response.

Published
2025
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2. Do you see what I see? Infants’ reasoning about others’ incomplete perceptions

Author

Whitney Beck and Yuyan Luo

Subjects
Visual perception, genetic structures, Point (typography), Cognitive Neuroscience, media_common.quotation_subject, Psychology of reasoning, Object (philosophy), Preference, Abstract reasoning, Perception, Developmental and Educational Psychology, Psychology, Social psychology, media_common
Abstract

Twelve-month-olds realize that when an agent cannot see an object, her incomplete perceptions still guide her goal-directed actions. What would happen if the agent had incomplete perceptions because she could see only one part of the object, for example one side of a screen? In the present research, 16-month-olds were first shown an agent who always pointed to a red object, as opposed to a black or a yellow object, suggesting that she preferred red over the other colours. Next, two screens were introduced while the agent was absent. The screens were (1) red or green on both sides; (2) red on the front (infants' side) but green on the back (the agent's side) or vice versa; or (3) only coloured red or green on the front. During test, the agent, who could see only the back of the screens, pointed to one of the two screens. The results revealed that while infants expected the agent to continue acting on her colour preference and point to the red rather than the green screen during test, they did so in accord with the agent's perception of the screens, rather than their own perceptions: they expected the agent to point to the red screen in (1), but to the green-front screen in (2), and they had no prediction of which screen the agent should point to in (3). The implications of the present findings for early psychological reasoning research are discussed.

Published
2010
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3. Bulldogs start season strong with 3-1 weekend

Author

Lafakis, Whitney Beck (15) Celebrates With The Team. Photo By Jimmy

Subjects
News, opinion and commentary, Sports and fitness, Butler University
Abstract

Byline: Whitney Beck (15) celebrates with the team. Photo by Jimmy Lafakis The Butler University volleyball team finished 3-1 at this weekend's Bulldog Brawl. The matches were held at Hinkle [...]

Published
2017

4. Do you see what I see? Infants' reasoning about others' incomplete perceptions

Author

Yuyan, Luo and Whitney, Beck

Subjects
Discrimination Learning, Male, Concept Formation, Orientation, Infant Behavior, Visual Perception, Humans, Infant, Attention, Female, Neuropsychological Tests, Photic Stimulation
Abstract

Twelve-month-olds realize that when an agent cannot see an object, her incomplete perceptions still guide her goal-directed actions. What would happen if the agent had incomplete perceptions because she could see only one part of the object, for example one side of a screen? In the present research, 16-month-olds were first shown an agent who always pointed to a red object, as opposed to a black or a yellow object, suggesting that she preferred red over the other colours. Next, two screens were introduced while the agent was absent. The screens were (1) red or green on both sides; (2) red on the front (infants' side) but green on the back (the agent's side) or vice versa; or (3) only coloured red or green on the front. During test, the agent, who could see only the back of the screens, pointed to one of the two screens. The results revealed that while infants expected the agent to continue acting on her colour preference and point to the red rather than the green screen during test, they did so in accord with the agent's perception of the screens, rather than their own perceptions: they expected the agent to point to the red screen in (1), but to the green-front screen in (2), and they had no prediction of which screen the agent should point to in (3). The implications of the present findings for early psychological reasoning research are discussed.

Published
2010

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