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1. The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations

Author

Villani, Anita, Davidson, Scott, Kanwar, Nisha, Lo, Winnie W., Li, Yisu, Cohen-Gogo, Sarah, Fuligni, Fabio, Edward, Lisa-Monique, Light, Nicholas, Layeghifard, Mehdi, Harripaul, Ricardo, Waldman, Larissa, Gallinger, Bailey, Comitani, Federico, Brunga, Ledia, Hayes, Reid, Anderson, Nathaniel D., Ramani, Arun K., Yuki, Kyoko E., Blay, Sasha, Johnstone, Brittney, Inglese, Cara, Hammad, Rawan, Goudie, Catherine, Shuen, Andrew, Wasserman, Jonathan D., Venier, Rosemarie E., Eliou, Marianne, Lorenti, Miranda, Ryan, Carol Ann, Braga, Michael, Gloven-Brown, Meagan, Han, Jianan, Montero, Maria, Spatare, Famida, Whitlock, James A., Scherer, Stephen W., Chun, Kathy, Somerville, Martin J., Hawkins, Cynthia, Abdelhaleem, Mohamed, Ramaswamy, Vijay, Somers, Gino R., Kyriakopoulou, Lianna, Hitzler, Johann, Shago, Mary, Morgenstern, Daniel A., Tabori, Uri, Meyn, Stephen, Irwin, Meredith S., Malkin, David, and Shlien, Adam

Published
2023
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2. Outcomes after late bone marrow and very early central nervous system relapse of childhood B-acute lymphoblastic leukemia: a report from the Children's Oncology Group phase III study AALL0433

Author

Lew, Glen, Chen, Yichen, Lu, Xiaomin, Rheingold, Susan R, Whitlock, James A, Devidas, Meenakshi, Hastings, Caroline A, Winick, Naomi J, Carroll, William L, Wood, Brent L, Borowitz, Michael J, Pulsipher, Michael A, and Hunger, Stephen P

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Oncology and Carcinogenesis, Clinical Trials and Supportive Activities, Clinical Research, Hematology, Transplantation, Pediatric Cancer, Childhood Leukemia, Pediatric Research Initiative, Rare Diseases, Orphan Drug, Cancer, Pediatric, 6.1 Pharmaceuticals, 4.2 Evaluation of markers and technologies, Evaluation of treatments and therapeutic interventions, Detection, screening and diagnosis, Good Health and Well Being, Bone Marrow, Central Nervous System, Child, Disease-Free Survival, Humans, Neoplasm, Residual, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Prognosis, Recurrence, Treatment Outcome, Cardiorespiratory Medicine and Haematology, Immunology, Cardiovascular medicine and haematology
Abstract

Outcomes after relapse of childhood B-acute lymphoblastic leukemia (B-ALL) are poor, and optimal therapy is unclear. Children's Oncology Group study AALL0433 evaluated a new platform for relapsed ALL. Between March 2007 and October 2013 AALL0433 enrolled 275 participants with late bone marrow or very early isolated central nervous system (iCNS) relapse of childhood B-ALL. Patients were randomized to receive standard versus intensive vincristine dosing; this randomization closed due to excess peripheral neuropathy in 2010. Patients with matched sibling donors received allogeneic hematopoietic cell transplantation (HCT) after the first three blocks of therapy. The prognostic value of minimal residual disease (MRD) was also evaluated in this study. The 3-year event free and overall survival (EFS/OS) for the 271 eligible patients were 63.6% +/- 3.0% and 72.3% +/- 2.8% respectively. MRD at the end of Induction-1 was highly predictive of outcome, with 3-year EFS/OS of 84.9 +/- 4.0% and 93.8 +/- 2.7% for patients with MRD

Published
2021

4. Outcome of children with multiply relapsed B-cell acute lymphoblastic leukemia: a therapeutic advances in childhood leukemia & lymphoma study

Author

Sun, Weili, Malvar, Jemily, Sposto, Richard, Verma, Anupam, Wilkes, Jennifer J, Dennis, Robyn, Heym, Kenneth, Laetsch, Theodore W, Widener, Melissa, Rheingold, Susan R, Oesterheld, Javier, Hijiya, Nobuko, Sulis, Maria Luisa, Huynh, Van, Place, Andrew E, Bittencourt, Henrique, Hutchinson, Raymond, Messinger, Yoav, Chang, Bill, Matloub, Yousif, Ziegler, David S, Gardner, Rebecca, Cooper, Todd, Ceppi, Francesco, Hermiston, Michelle, Dalla-Pozza, Luciano, Schultz, Kirk R, Gaynon, Paul, Wayne, Alan S, and Whitlock, James A

Subjects
Childhood Leukemia, Pediatric Research Initiative, Hematology, Orphan Drug, Pediatric, Clinical Research, Rare Diseases, Cancer, Pediatric Cancer, Antineoplastic Agents, B-Lymphocytes, Bone Marrow, Child, Child, Preschool, Disease-Free Survival, Female, Humans, Infant, Male, Neoplasm Recurrence, Local, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Remission Induction, Retrospective Studies, Salvage Therapy, Clinical Sciences, Oncology and Carcinogenesis, Immunology
Abstract

The survival of pediatric patients with multiply relapsed and/or refractory (R/R) B-cell acute lymphoblastic leukemia has historically been very poor; however, data are limited in the current era. We conducted a retrospective study to determine the outcome of multiply R/R childhood B-ALL treated at 24 TACL institutions between 2005 and 2013. Patient information, treatment, and response were collected. Prognostic factors influencing the complete remission (CR) rate and event-free survival (EFS) were analyzed. The analytic set included 578 salvage treatment attempts among 325 patients. CR rates (mean ± SE) were 51 ± 4% for patients with bone marrow R/R B-ALL who underwent a second salvage attempt, 37 ± 6% for a third attempt, and 31 ± 6% for the fourth through eighth attempts combined. For patients achieving a CR after their second, third, and fourth through eighth attempts, the 2 year EFS was 41 ± 6%, 13 ± 7%, and 27 ± 13% respectively. Our results showed slight improvement when compared to previous studies. This is the largest and most recent study to date that evaluates the outcome of this patient population. Our data will provide detailed reference for the evaluation of new agents being developed for childhood B-ALL.

Published
2018

5. ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition

Author

Kemps, Paul G., Picarsic, Jennifer, Durham, Benjamin H., Hélias-Rodzewicz, Zofia, Hiemcke-Jiwa, Laura, van den Bos, Cor, van de Wetering, Marianne D., van Noesel, Carel J.M., van Laar, Jan A.M., Verdijk, Robert M., Flucke, Uta E., Hogendoorn, Pancras C.W., Woei-A-Jin, F. J. Sherida H., Sciot, Raf, Beilken, Andreas, Feuerhake, Friedrich, Ebinger, Martin, Möhle, Robert, Fend, Falko, Bornemann, Antje, Wiegering, Verena, Ernestus, Karen, Méry, Tina, Gryniewicz-Kwiatkowska, Olga, Dembowska-Baginska, Bozenna, Evseev, Dmitry A., Potapenko, Vsevolod, Baykov, Vadim V., Gaspari, Stefania, Rossi, Sabrina, Gessi, Marco, Tamburrini, Gianpiero, Héritier, Sébastien, Donadieu, Jean, Bonneau-Lagacherie, Jacinthe, Lamaison, Claire, Farnault, Laure, Fraitag, Sylvie, Jullié, Marie-Laure, Haroche, Julien, Collin, Matthew, Allotey, Jackie, Madni, Majid, Turner, Kerry, Picton, Susan, Barbaro, Pasquale M., Poulin, Alysa, Tam, Ingrid S., El Demellawy, Dina, Empringham, Brianna, Whitlock, James A., Raghunathan, Aditya, Swanson, Amy A., Suchi, Mariko, Brandt, Jon M., Yaseen, Nabeel R., Weinstein, Joanna L., Eldem, Irem, Sisk, Bryan A., Sridhar, Vaishnavi, Atkinson, Mandy, Massoth, Lucas R., Hornick, Jason L., Alexandrescu, Sanda, Yeo, Kee Kiat, Petrova-Drus, Kseniya, Peeke, Stephen Z., Muñoz-Arcos, Laura S., Leino, Daniel G., Grier, David D., Lorsbach, Robert, Roy, Somak, Kumar, Ashish R., Garg, Shipra, Tiwari, Nishant, Schafernak, Kristian T., Henry, Michael M., van Halteren, Astrid G.S., Abla, Oussama, Diamond, Eli L., and Emile, Jean-François

Published
2022
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6. Access to innovative therapies in pediatric oncology: Report of the nationwide experience in Canada

Author

Judd, Sandra, primary, Revon‐Riviere, Gabriel, additional, Grover, Stephanie A., additional, Deyell, Rebecca J., additional, Vanan, Magimairajan Issai, additional, Lewis, Victor A., additional, Pecheux, Lucie, additional, Zorzi, Alexandra P., additional, Goudie, Catherine, additional, Santiago, Raoul, additional, Tran, Thai Hoa, additional, Abbott, Lesleigh S., additional, Brossard, Josee, additional, Moorehead, Paul, additional, Alvi, Saima, additional, Portwine, Carol, additional, Denburg, Avram, additional, Whitlock, James A., additional, Cohen‐Gogo, Sarah, additional, and Morgenstern, Daniel A., additional

Published
2024
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7. Developing a partnership to improve health care delivery to children <18 years with cancer and blood disorders in the English-speaking Caribbean: lessons from the SickKids-Caribbean Initiative (SCI)

Author

Reece-Mills, Michelle, primary, Bodkyn, Curt, additional, Baxter, Jo-Anna B., additional, Allen, Upton, additional, Alexis, Cheryl, additional, Browne-Farmer, Chantelle, additional, Craig, Jenna, additional, de Young, Stephanie, additional, Denburg, Avram, additional, Dindial, Kevon, additional, Fleming-Carroll, Bonnie, additional, Gibson, Tracey, additional, Gupta, Sumit, additional, Knight-Madden, Jennifer, additional, Manley-Kucey, Margaret, additional, Mclean-Salmon, Sharon, additional, Ocho, Oscar Noel, additional, Orrigio, Kadine, additional, Read, Stanley, additional, Sin Quee, Corrine, additional, Smith, Brian, additional, Thame, Minerva, additional, Wharfe, Gilian, additional, Whitlock, James A., additional, Zlotkin, Stanley, additional, and Blanchette, Victor, additional

Published
2023
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8. Blinatumomab versus historical standard therapy in pediatric patients with relapsed/refractory Ph-negative B-cell precursor acute lymphoblastic leukemia

Author

Locatelli, Franco, Whitlock, James A., Peters, Christina, Chen-Santel, Christiane, Chia, Victoria, Dennis, Robyn M., Heym, Kenneth M., Katz, Aaron J., Kelsh, Michael A., Sposto, Richard, Tu, Huakang, Tuglus, Catherine A., Verma, Anupam, Vinti, Luciana, Wilkes, Jennifer J., Zubarovskaja, Nathalya, Zugmaier, Gerhard, von Stackelberg, Arend, and Sun, Weili

Published
2020
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11. Children's Oncology Group AALL1331: Phase III Trial of Blinatumomab in Children, Adolescents, and Young Adults With Low-Risk B-Cell ALL in First Relapse

Author

Hogan, Laura E., primary, Brown, Patrick A., additional, Ji, Lingyun, additional, Xu, Xinxin, additional, Devidas, Meenakshi, additional, Bhatla, Teena, additional, Borowitz, Michael J., additional, Raetz, Elizabeth A., additional, Carroll, Andrew, additional, Heerema, Nyla A., additional, Zugmaier, Gerhard, additional, Sharon, Elad, additional, Bernhardt, Melanie B., additional, Terezakis, Stephanie A., additional, Gore, Lia, additional, Whitlock, James A., additional, Hunger, Stephen P., additional, and Loh, Mignon L., additional

Published
2023
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14. Instrument-Assisted Soft Tissue Mobilization Forces Applied by Trained Clinicians During a Simulated Treatment.

Author

Martonick, Nickolai J.P., Reeves, Ashley J., Whitlock, James A., Stevenson, Taylor C., Cheatham, Scott W., McGowan, Craig P., and Baker, Russell T.

Subjects
WEIGHTS & measures, MUSCLE diseases, MANIPULATION therapy, DESCRIPTIVE statistics, SIMULATION methods in education, THERAPEUTIC immobilization, DATA analysis software, EQUIPMENT & supplies
Abstract

Context: Instrument-assisted Soft Tissue Mobilization (IASTM) is a therapeutic intervention used by clinicians to identify and treat myofascial dysfunction or pathology. However, little is known about the amount of force used by clinicians during an IASTM treatment and how it compares to reports of force in the current literature. Objective: To quantify the range of force applied by trained clinicians during a simulated IASTM treatment scenario. Design: Experimental. Setting: University research laboratory. Participants: Eleven licensed clinicians (physical therapist = 2, chiropractor = 2, and athletic trainer = 7) with professional IASTM training participated in the study. The participants reported a range of credentialed experience from 1 to 15 years (mean = 7 [4.7] y; median = 6 y). Intervention: Participants performed 15 one-handed unidirectional sweeping strokes with each of the 5 instruments for a total of 75 data points each. Force data were collected from a force plate with an attached skin simulant during a hypothetical treatment scenario. Main Outcome Measures: Peak force and average forces for individual strokes across all instruments were identified. Averages for these forces were calculated for all participants combined, as well as for individual participants. Results: The average of peak forces produced by our sample of trained clinicians was 6.7 N and the average mean forces was 4.5 N. Across individual clinicians, average peak forces ranged from 2.6 to 14.0 N, and average mean forces ranged from 1.6 to 10.0 N. Conclusions: The clinicians in our study produced a broad range of IASTM forces. The observed forces in our study were similar to those reported in prior research examining an IASTM treatment to the gastrocnemius of healthy individuals and greater than what has been reported as effective in treating delayed onset muscle soreness. Our data can be used by researchers examining clinically relevant IASTM treatment force on patient outcomes. [ABSTRACT FROM AUTHOR]

Published
2022
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16. Ensuring access to innovative therapies for children, adolescents, and young adults across Canada: The single patient study experience

Author

Revon-Riviere, Gabriel, primary, Young, Leah C, additional, Stephenson, Elizabeth A, additional, Brodeur-Robb, Kathy, additional, Cohen-Gogo, Sarah, additional, Deyell, Rebecca, additional, Lacaze-Masmonteil, Thierry, additional, Palmer, Antonia, additional, Parekh, Rulan S, additional, Whitlock, James A, additional, and Morgenstern, Daniel A, additional

Published
2023
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18. Figure S2 from Efficacy and Safety of Dabrafenib in Pediatric Patients with BRAF V600 Mutation–Positive Relapsed or Refractory Low-Grade Glioma: Results from a Phase I/IIa Study

Author

Hargrave, Darren R., primary, Bouffet, Eric, primary, Tabori, Uri, primary, Broniscer, Alberto, primary, Cohen, Kenneth J., primary, Hansford, Jordan R., primary, Geoerger, Birgit, primary, Hingorani, Pooja, primary, Dunkel, Ira J., primary, Russo, Mark W., primary, Tseng, Lillian, primary, Dasgupta, Kohinoor, primary, Gasal, Eduard, primary, Whitlock, James A., primary, and Kieran, Mark W., primary

Published
2023
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19. Table S3 from A Phase I and Pharmacokinetic Study of Oral Dabrafenib in Children and Adolescent Patients with Recurrent or Refractory BRAF V600 Mutation–Positive Solid Tumors

Author

Kieran, Mark W., primary, Geoerger, Birgit, primary, Dunkel, Ira J., primary, Broniscer, Alberto, primary, Hargrave, Darren, primary, Hingorani, Pooja, primary, Aerts, Isabelle, primary, Bertozzi, Anne-Isabelle, primary, Cohen, Kenneth J., primary, Hummel, Trent R., primary, Shen, Violet, primary, Bouffet, Eric, primary, Pratilas, Christine A., primary, Pearson, Andrew D.J., primary, Tseng, Lillian, primary, Nebot, Noelia, primary, Green, Steven, primary, Russo, Mark W., primary, and Whitlock, James A., primary

Published
2023
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22. The expanding role of primary care in cancer control

Author

Rubin, Greg, Berendsen, Annette, Crawford, S Michael, Dommett, Rachel, Earle, Craig, Emery, Jon, Fahey, Tom, Grassi, Luigi, Grunfeld, Eva, Gupta, Sumit, Hamilton, Willie, Hiom, Sara, Hunter, David, Lyratzopoulos, Georgios, Macleod, Una, Mason, Robert, Mitchell, Geoffrey, Neal, Richard D, Peake, Michael, Roland, Martin, Seifert, Bohumil, Sisler, Jeff, Sussman, Jonathan, Taplin, Stephen, Vedsted, Peter, Voruganti, Teja, Walter, Fiona, Wardle, Jane, Watson, Eila, Weller, David, Wender, Richard, Whelan, Jeremy, Whitlock, James, Wilkinson, Clare, de Wit, Niek, and Zimmermann, Camilla

Published
2015
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23. The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations

Author

Villani, Anita, primary, Davidson, Scott, additional, Kanwar, Nisha, additional, Lo, Winnie W., additional, Li, Yisu, additional, Cohen-Gogo, Sarah, additional, Fuligni, Fabio, additional, Edward, Lisa-Monique, additional, Light, Nicholas, additional, Layeghifard, Mehdi, additional, Harripaul, Ricardo, additional, Waldman, Larissa, additional, Gallinger, Bailey, additional, Comitani, Federico, additional, Brunga, Ledia, additional, Hayes, Reid, additional, Anderson, Nathaniel D., additional, Ramani, Arun K., additional, Yuki, Kyoko E., additional, Blay, Sasha, additional, Johnstone, Brittney, additional, Inglese, Cara, additional, Hammad, Rawan, additional, Goudie, Catherine, additional, Shuen, Andrew, additional, Wasserman, Jonathan D., additional, Venier, Rosemarie E., additional, Eliou, Marianne, additional, Lorenti, Miranda, additional, Ryan, Carol Ann, additional, Braga, Michael, additional, Gloven-Brown, Meagan, additional, Han, Jianan, additional, Montero, Maria, additional, Spatare, Famida, additional, Whitlock, James A., additional, Scherer, Stephen W., additional, Chun, Kathy, additional, Somerville, Martin J., additional, Hawkins, Cynthia, additional, Abdelhaleem, Mohamed, additional, Ramaswamy, Vijay, additional, Somers, Gino R., additional, Kyriakopoulou, Lianna, additional, Hitzler, Johann, additional, Shago, Mary, additional, Morgenstern, Daniel A., additional, Tabori, Uri, additional, Meyn, Stephen, additional, Irwin, Meredith S., additional, Malkin, David, additional, and Shlien, Adam, additional

Published
2022
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24. Prognostic Importance of Cytogenetic Subgroups in Relapse Risk Stratification in Children and Young Adults with First Relapsed B-ALL: A Children's Oncology Group Study AALL1331

Author

Bhatla, Teena, primary, Hogan, Laura, additional, Xu, Xinxin, additional, Ji, Lingyun, additional, Carroll, Andrew J., additional, Heerema, Nyla A., additional, Shago, Mary, additional, Gore, Lia, additional, Whitlock, James A., additional, Hunger, Stephen P., additional, Loh, Mignon L., additional, and Brown, Patrick A., additional

Published
2022
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26. New Zealand is actively improving school acoustics with governmentled initiatives.

Author

Whitlock, James

Subjects
ACOUSTICAL engineering, NOISE control, SOUND measurement, SOUNDPROOFING
Abstract

New Zealand's Ministry of Education is taking active steps to ensure that the country's 35,000+ classrooms are fit for purpose. Acoustics is a primary factor in central government's School Property Strategy 2030, which has informed three major initiatives to establish and implement sensible acoustic regulations. All three initiatives are underway. First is the Designing Quality Learning Spaces (DQLS) - Acoustics v3.0 document, launched in December 2020. It sets out mandatory requirements for reverberation time (RT), background noise and sound insulation in new and refurbished learning spaces. Second is the Ngā Iti Kahurangi 'small and remote schools' programme. We are measuring RTs in 630 schools, assessing compliance with DQLS and adding absorption where necessary. The plan is to scale this programme up to include many more schools across the country. Third is the Internal Environmental Monitoring (IEM) programme. Sound levels (and other environmental factors like temperature, humidity and CO2) are continuously measured in a range of schools, and reviewed to inform improvements. These initiatives aim to provide quality learning environments for New Zealand children, and this paper sets out how they have been designed and implemented. Similar initiatives could be adopted by other countries to improve acoustic quality in their classrooms. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Nelarabine, etoposide, and cyclophosphamide in relapsed pediatric T‐acute lymphoblastic leukemia and T‐lymphoblastic lymphoma (study T2008‐002 NECTAR)

Author

Whitlock, James A., primary, Malvar, Jemily, additional, Dalla‐Pozza, Luciano, additional, Goldberg, John M., additional, Silverman, Lewis B., additional, Ziegler, David S., additional, Attarbaschi, Andishe, additional, Brown, Patrick A., additional, Gardner, Rebecca A., additional, Gaynon, Paul S., additional, Hutchinson, Raymond, additional, Huynh, Van T., additional, Jeha, Sima, additional, Marcus, Leigh, additional, Messinger, Yoav, additional, Schultz, Kirk R., additional, Cassar, Jeannette, additional, Locatelli, Franco, additional, Zwaan, C. Michel, additional, Wood, Brent L., additional, Sposto, Richard, additional, and Gore, Lia, additional

Published
2022
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29. Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group

Author

Buitenkamp, Trudy D., Izraeli, Shai, Zimmermann, Martin, Forestier, Erik, Heerema, Nyla A., van den Heuvel-Eibrink, Marry M., Pieters, Rob, Korbijn, Carin M., Silverman, Lewis B., Schmiegelow, Kjeld, Liang, Der-Cheng, Horibe, Keizo, Arico, Maurizio, Biondi, Andrea, Basso, Giuseppe, Rabin, Karin R., Schrappe, Martin, Cario, Gunnar, Mann, Georg, Morak, Maria, Panzer-Grümayer, Renate, Mondelaers, Veerle, Lammens, Tim, Cavé, Hélène, Stark, Batia, Ganmore, Ithamar, Moorman, Anthony V., Vora, Ajay, Hunger, Stephen P., Pui, Ching-Hon, Mullighan, Charles G., Manabe, Atsushi, Escherich, Gabriele, Kowalczyk, Jerzy R., Whitlock, James A., and Zwaan, C. Michel

Published
2014
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30. Low-Dose Metronomic Topotecan and Pazopanib (TOPAZ) in Children with Relapsed or Refractory Solid Tumors: A C17 Canadian Phase I Clinical Trial

Author

Manji, Arif, primary, Samson, Yvan, additional, Deyell, Rebecca J., additional, Johnston, Donna L., additional, Lewis, Victor A., additional, Zorzi, Alexandra P., additional, Berman, Jason N., additional, Brodeur-Robb, Kathy, additional, Morrison, Ellen, additional, Kee, Lynn, additional, Kumar, Sushil, additional, Baruchel, Sylvain, additional, Whitlock, James A., additional, and Morgenstern, Daniel A., additional

Published
2022
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32. Descriptive Analysis of Forces Applied by Trained Clinicians During 2-Handed Instrument-Assisted Soft Tissue Mobilization.

Author

Stevenson, Taylor C., Whitlock, James A., Martonick, Nickolai, Cheatham, Scott W., Reeves, Ashley, McGowan, Craig, and Baker, Russell T.

Subjects
*INSTRUMENT-assisted soft tissue mobilization, *STATISTICAL sampling, *RANDOMIZED controlled trials, *DESCRIPTIVE statistics, *CROSSOVER trials, *RESEARCH methodology, *DATA analysis software
Abstract

Instrument-assisted soft tissue mobilization (IASTM) is a common intervention among clinicians. Despite its popularity, little is known about the forces applied by the clinician using the instruments during treatment. The purpose of this investigation was to examine the forces applied by trained clinicians using IASTM instruments during a simulated treatment. Eleven IASTM–trained (Graston Technique, Técnica Gavilán, or RockBlades) clinicians (physical therapists = 2, chiropractors = 2, athletic trainers = 7) participated in the study. Each clinician performed 75 two-handed strokes distributed evenly across 5 IASTM instruments on a skin simulant attached to a force plate. Instrument-assisted soft tissue mobilization stroke application was analyzed for peak normal forces and mean normal forces by stroke. We observed an average peak normal force of 8.9 N and mean normal force of 6.0 N across all clinicians and instruments. Clinicians and researchers may use the descriptive values as reference for the application of IASTM in practice and research. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Temsirolimus combined with cyclophosphamide and etoposide for pediatric patients with relapsed/refractory acute lymphoblastic leukemia: a Therapeutic Advances in Childhood Leukemia Consortium trial (TACL 2014-001)

Author

Tasian, Sarah K., primary, Silverman, Lewis B., additional, Whitlock, James A., additional, Sposto, Richard, additional, Loftus, Joseph P., additional, Schafer, Eric S., additional, Schultz, Kirk R., additional, Hutchinson, Raymond J., additional, Gaynon, Paul S., additional, Orgel, Etan, additional, Bateman, Caroline M., additional, Cooper, Todd M., additional, Laetsch, Theodore W., additional, Sulis, Maria Luisa, additional, Chi, Yueh-Yun, additional, Malvar, Jemily, additional, Wayne, Alan S., additional, and Rheingold, Susan R., additional

Published
2022
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39. Performance of the McGill Interactive Pediatric OncoGenetic Guidelines for Identifying Cancer Predisposition Syndromes

Author

Goudie, Catherine, primary, Witkowski, Leora, additional, Cullinan, Noelle, additional, Reichman, Lara, additional, Schiller, Ian, additional, Tachdjian, Melissa, additional, Armstrong, Linlea, additional, Blood, Katherine A., additional, Brossard, Josée, additional, Brunga, Ledia, additional, Cacciotti, Chantel, additional, Caswell, Kimberly, additional, Cellot, Sonia, additional, Clark, Mary Egan, additional, Clinton, Catherine, additional, Coltin, Hallie, additional, Felton, Kathleen, additional, Fernandez, Conrad V., additional, Fleming, Adam J., additional, Fuentes-Bolanos, Noemi, additional, Gibson, Paul, additional, Grant, Ronald, additional, Hammad, Rawan, additional, Harrison, Lynn W., additional, Irwin, Meredith S., additional, Johnston, Donna L., additional, Kane, Sarah, additional, Lafay-Cousin, Lucie, additional, Lara-Corrales, Irene, additional, Larouche, Valerie, additional, Mathews, Natalie, additional, Meyn, M. Stephen, additional, Michaeli, Orli, additional, Perrier, Renée, additional, Pike, Meghan, additional, Punnett, Angela, additional, Ramaswamy, Vijay, additional, Say, Jemma, additional, Somers, Gino, additional, Tabori, Uri, additional, Thibodeau, My Linh, additional, Toupin, Annie-Kim, additional, Tucker, Katherine M., additional, van Engelen, Kalene, additional, Vairy, Stephanie, additional, Waespe, Nicolas, additional, Warby, Meera, additional, Wasserman, Jonathan D., additional, Whitlock, James A., additional, Sinnett, Daniel, additional, Jabado, Nada, additional, Nathan, Paul C., additional, Shlien, Adam, additional, Kamihara, Junne, additional, Deyell, Rebecca J., additional, Ziegler, David S., additional, Nichols, Kim E., additional, Dendukuri, Nandini, additional, Malkin, David, additional, Villani, Anita, additional, and Foulkes, William D., additional

Published
2021
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41. Tisagenlecleucel Therapy Is Safe and Effective for Children with Down Syndrome with ALL in First Relapse

Author

Krueger, Joerg, primary, Hitzler, Johann K, additional, Mourad, Stephanie Audrey, additional, Bassal, Mylene, additional, Cairney, Elizabeth, additional, Crooks, Bruce N., additional, Punnett, Angela, additional, Alexander, Sarah, additional, Ali, Muhammad, additional, Bittencourt, Henrique, additional, Whitlock, James A., additional, and Gupta, Sumit, additional

Published
2021
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42. Vincristine Sulfate Liposome Injection (VSLI, Marqibo®) in Combination with UK ALL-R3 Induction Chemotherapy for Children, Adolescents and Young Adults with Relapsed Acute Lymphoblastic Leukemia (ALL): A Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) Consortium Trial

Author

Shah, Nirali N., primary, Schafer, Eric S, additional, Heym, Kenneth Matthew, additional, Place, Andrew E., additional, Burns, Melissa A., additional, Gossai, Nathan, additional, Shaw, Peter, additional, Burke, Michael J., additional, Chang, Bill H., additional, Hermiston, Michelle L., additional, Schore, Reuven J, additional, Rushing, Teresa, additional, Jarosinski, Paul F, additional, Sposto, Richard, additional, Florendo, Ellynore, additional, Malvar, Jemily, additional, Chi, Yueh-Yun, additional, Whitlock, James A., additional, Silverman, Lewis B., additional, Bhojwani, Deepa, additional, and Wayne, Alan S., additional

Published
2021
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44. A Randomized Phase 3 Trial of Blinatumomab Vs. Chemotherapy As Post-Reinduction Therapy in Low Risk (LR) First Relapse of B-Acute Lymphoblastic Leukemia (B-ALL) in Children and Adolescents/Young Adults (AYAs): A Report from Children's Oncology Group Study AALL1331

Author

Brown, Patrick A., primary, Ji, Lingyun, additional, Xu, Xinxin, additional, Devidas, Meenakshi, additional, Hogan, Laura, additional, Bhatla, Teena, additional, Borowitz, Michael, additional, Raetz, Elizabeth A., additional, Gore, Lia, additional, Whitlock, James A., additional, Hunger, Stephen P., additional, and Loh, Mignon L., additional

Published
2021
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45. Intercontinental collaboration in clinical trials for children and adolescents with cancer—A systematic review by ACCELERATE

Author

Rojas, Teresa, primary, Pearson, Andrew J., additional, Scobie, Nicole, additional, Knox, Leona, additional, Wariabharaj, Darshan, additional, Kearns, Pamela, additional, Vassal, Gilles, additional, Reaman, Gregory, additional, Alonzo, Todd, additional, Biondi, Andrea, additional, Brodeur‐Robb, Kathy, additional, Rojas, Teresa, additional, Fouladi, Maryam, additional, Gross, Thomas, additional, Hunger, Stephen, additional, McCowage, Geoff, additional, Pappo, Alberto, additional, Schrappe, Martin, additional, Grazia Valsecchi, Maria, additional, Weigel, Brenda, additional, Wejbora, Peter, additional, Whitlock, James, additional, Zwaan, Michel, additional, Buenger, Vickie, additional, Ludwinski, Donna, additional, Barry, Elly, additional, Neville, Kathleen, additional, Sharma, Anjali, additional, and Karres, Dominik, additional

Published
2021
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46. Management and Outcome of Patients With Langerhans Cell Histiocytosis and Single-Bone CNS-Risk Lesions: A Multi-Institutional Retrospective Study

Author

Chellapandian, Deepak, Shaikh, Furqan, van den Bos, Cor, Somers, Gino R., Astigarraga, Itziar, Jubran, Rima, Degar, Barbara, Carret, Anne-Sophie, Mandel, Karen, Belletrutti, Mark, Dix, David, Visser, Johannes, Abuhadra, Nour, Chang, Tiffany, Rollins, Barret, Whitlock, James, Weitzman, Sheila, and Abla, Oussama

Published
2015
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