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1. Patient and operative factors influence delayed discharge following bariatric surgery in an enhanced recovery setting

Author

Katz-Summercorn, A., primary, Arhi, C., additional, Agyemangyeboah, D., additional, Cirocchi, N., additional, Musendeki, D., additional, McGrandles, I. Fitt.R., additional, Zalin, A., additional, Foldi, I., additional, Rashid, F., additional, Adil, Md T., additional, Jain, V., additional, Mamidanna, R., additional, Jambulingam, P., additional, Munasinghe, A., additional, Whitelaw, D., additional, and Al-Taan, O., additional

Published
2023
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2. 30-day morbidity and mortality of sleeve gastrectomy, Roux-en-Y gastric bypass and one anastomosis gastric bypass: a propensity score-matched analysis of the GENEVA data

Author

Singhal R., Cardoso V. R., Wiggins T., Super J., Ludwig C., Gkoutos G. V., Mahawar K., Pedziwiatr M., Major P., Zarzycki P., Pantelis A., Lapatsanis D. P., Stravodimos G., Matthys C., Focquet M., Vleeschouwers W., Spaventa A. G., Zerrweck C., Vitiello A., Berardi G., Musella M., Sanchez-Meza A., Cantu F. J., Mora F., Cantu M. A., Katakwar A., Reddy D. N., Elmaleh H., Hassan M., Elghandour A., Elbanna M., Osman A., Khan A., layani L., Kiran N., Velikorechin A., Solovyeva M., Melali H., Shahabi S., Agrawal A., Shrivastava A., Sharma A., Narwaria B., Narwaria M., Raziel A., Sakran N., Susmallian S., Karagoz L., Akbaba M., Piskin S. Z., Balta A. Z., Senol Z., Manno E., Iovino M. G., Qassem M., Arana-Garza S., Povoas H. P., Vilas-Boas M. L., Naumann D., Li A., Ammori B. J., Balamoun H., Salman M., Nasta A. M., Goel R., Sanchez-Aguilar H., Herrera M. F., Abou-mrad A., Cloix L., Mazzini G. S., Kristem L., Lazaro A., Campos J., Bernardo J., Gonzalez J., Trindade C., Viveiros O., Ribeiro R., Goitein D., Hazzan D., Segev L., Beck T., Reyes H., Monterrubio J., Garcia P., Benois M., Kassir R., Contine A., Elshafei M., Aktas S., Weiner S., Heidsieck T., Level L., Pinango S., Ortega P. M., Moncada R., Valenti V., Vlahovic I., Boras Z., Liagre A., Martini F., Juglard G., Motwani M., Saggu S. S., Momani H. A., Lopez L. A. A., Cortez M. A. C., Zavala R. A., D'Haese RN C., Kempeneers I., Himpens J., Lazzati A., Paolino L., Bathaei S., Bedirli A., Yavuz A., Buyukkasap C., Ozaydin S., Kwiatkowski A., Bartosiak K., Waledziak M., Santonicola A., Angrisani L., Iovino P., Palma R., Iossa A., Boru C. E., De Angelis F., Silecchia G., Hussain A., Balchandra S., Coltell I. B., Perez J. L., Bohra A., Awan A. K., Madhok B., Leeder P. C., Awad S., Al-Khyatt W., Shoma A., Elghadban H., Ghareeb S., Mathews B., Kurian M., Larentzakis A., Vrakopoulou G. Z., Albanopoulos K., Bozdag A., Lale A., Kirkil C., Dincer M., Bashir A., Haddad A., Hijleh L. A., Zilberstein B., de Marchi D. D., Souza W. P., Broden C. M., Gislason H., Shah K., Ambrosi A., Pavone G., Tartaglia N., Kona S. L. K., Kalyan K., Perez C. E. G., Botero M. A. F., Covic A., Timofte D., Maxim M., Faraj D., Tseng L., Liem R., Oren G., Dilektasli E., Yalcin I., AlMukhtar H., Hadad M. A., Mohan R., Arora N., Bedi D., Rives-Lange C., Chevallier J. -M., Poghosyan T., Sebbag H., Zinai L., Khaldi S., Mauchien C., Mazza D., Dinescu G., Rea B., Perez-Galaz F., Zavala L., Besa A., Curell A., Balibrea J. M., Vaz C., Galindo L., Silva N., Caballero J. L. E., Sebastian S. O., Marchesini J. C. D., da Fonseca Pereira R. A., Sobottka W. H., Fiolo F. E., Turchi M., Coelho A. C. J., Zacaron A. L., Barbosa A., Quinino R., Menaldi G., Paleari N., Martinez-Duartez P., de Esparza G. M. A. R., Esteban V. S., Torres A., Garcia-Galocha J. L., Josa M., Pacheco-Garcia J. M., Mayo-Ossorio M. A., Chowbey P., Soni V., de Vasconcelos Cunha H. A., Castilho M. V., Ferreira R. M. A., Barreiro T. A., Charalabopoulos A., Sdralis E., Davakis S., Bomans B., Dapri G., Van Belle K., Takieddine M., Vaneukem P., Karaca E. S. A., Karaca F. C., Sumer A., Peksen C., Savas O. A., Chousleb E., Elmokayed F., Fakhereldin I., Aboshanab H. M., Swelium T., Gudal A., Gamloo L., Ugale A., Ugale S., Boeker C., Reetz C., Hakami I. A., Mall J., Alexandrou A., Baili E., Bodnar Z., Maleckas A., Gudaityte R., Guldogan C. E., Gundogdu E., Ozmen M. M., Thakkar D., Dukkipati N., Shah P. S., Shah S. S., Adil M. T., Jambulingam P., Mamidanna R., Whitelaw D., Jain V., Veetil D. K., Wadhawan R., Torres M., Tinoco T., Leclercq W., Romeijn M., van de Pas K., Alkhazraji A. K., Taha S. A., Ustun M., Yigit T., Inam A., Burhanulhaq M., Pazouki A., Eghbali F., Kermansaravi M., Jazi A. H. D., Mahmoudieh M., Mogharehabed N., Tsiotos G., Stamou K., Rodriguez F. J. B., Navarro M. A. R., Torres O. M., Martinez S. L., Tamez E. R. M., Cornejo G. A. M., Flores J. E. G., Mohammed D. A., Elfawal M. H., Shabbir A., Guowei K., So J. B., Kaplan E. T., Kaplan M., Kaplan T., Pham D. T., Rana G., Kappus M., Gadani R., Kahitan M., Pokharel K., Osborne A., Pournaras D., Hewes J., Napolitano E., Chiappetta S., Bottino V., Dorado E., Schoettler A., Gaertner D., Fedtke K., Aguilar-Espinosa F., Aceves-Lozano S., Balani A., Nagliati C., Pennisi D., Rizzi A., Frattini F., Foschi D., Benuzzi L., Parikh C., Shah H., Pinotti E., Montuori M., Borrelli V., Dargent J., Copaescu C. A., Hutopila I., Smeu B., Witteman B., Hazebroek E., Deden L., Heusschen L., Okkema S., Aufenacker T., den Hengst W., Vening W., van der Burgh Y., Ghazal A., Ibrahim H., Niazi M., Alkhaffaf B., Altarawni M., Cesana G. C., Anselmino M., Uccelli M., Olmi S., Stier C., Akmanlar T., Sonnenberg T., Schieferbein U., Marcolini A., Awruch D., Vicentin M., de Souza Bastos E. L., Gregorio S. A., Ahuja A., Mittal T., Bolckmans R., Baratte C., Wisnewsky J. A., Genser L., Chong L., Taylor L., Ward S., Hi M. W., Heneghan H., Fearon N., Plamper A., Rheinwalt K., Geoghegan J., Ng K. C., Kaseja K., Kotowski M., Samarkandy T. A., Leyva-Alvizo A., Corzo-Culebro L., Wang C., Yang W., Dong Z., Riera M., Jain R., Hamed H., Said M., Zarzar K., Garcia M., Turkcapar A. G., Sen O., Baldini E., Conti L., Wietzycoski C., Lopes E., Pintar T., Salobir J., Aydin C., Atici S. D., Ergin A., Ciyiltepe H., Bozkurt M. A., Kizilkaya M. C., Onalan N. B. D., Zuber M. N. B. A., Wong W. J., Garcia A., Vidal L., Beisani M., Pasquier J., Vilallonga R., Sharma S., Parmar C., Lee L., Sufi P., Sinan H., Saydam M., Singhal, R., Cardoso, V. R., Wiggins, T., Super, J., Ludwig, C., Gkoutos, G. V., Mahawar, K., Pedziwiatr, M., Major, P., Zarzycki, P., Pantelis, A., Lapatsanis, D. P., Stravodimos, G., Matthys, C., Focquet, M., Vleeschouwers, W., Spaventa, A. G., Zerrweck, C., Vitiello, A., Berardi, G., Musella, M., Sanchez-Meza, A., Cantu, F. J., Mora, F., Cantu, M. A., Katakwar, A., Reddy, D. N., Elmaleh, H., Hassan, M., Elghandour, A., Elbanna, M., Osman, A., Khan, A., Layani, L., Kiran, N., Velikorechin, A., Solovyeva, M., Melali, H., Shahabi, S., Agrawal, A., Shrivastava, A., Sharma, A., Narwaria, B., Narwaria, M., Raziel, A., Sakran, N., Susmallian, S., Karagoz, L., Akbaba, M., Piskin, S. Z., Balta, A. Z., Senol, Z., Manno, E., Iovino, M. G., Qassem, M., Arana-Garza, S., Povoas, H. P., Vilas-Boas, M. L., Naumann, D., Li, A., Ammori, B. J., Balamoun, H., Salman, M., Nasta, A. M., Goel, R., Sanchez-Aguilar, H., Herrera, M. F., Abou-mrad, A., Cloix, L., Mazzini, G. S., Kristem, L., Lazaro, A., Campos, J., Bernardo, J., Gonzalez, J., Trindade, C., Viveiros, O., Ribeiro, R., Goitein, D., Hazzan, D., Segev, L., Beck, T., Reyes, H., Monterrubio, J., Garcia, P., Benois, M., Kassir, R., Contine, A., Elshafei, M., Aktas, S., Weiner, S., Heidsieck, T., Level, L., Pinango, S., Ortega, P. M., Moncada, R., Valenti, V., Vlahovic, I., Boras, Z., Liagre, A., Martini, F., Juglard, G., Motwani, M., Saggu, S. S., Momani, H. A., Lopez, L. A. A., Cortez, M. A. C., Zavala, R. A., D'Haese RN, C., Kempeneers, I., Himpens, J., Lazzati, A., Paolino, L., Bathaei, S., Bedirli, A., Yavuz, A., Buyukkasap, C., Ozaydin, S., Kwiatkowski, A., Bartosiak, K., Waledziak, M., Santonicola, A., Angrisani, L., Iovino, P., Palma, R., Iossa, A., Boru, C. E., De Angelis, F., Silecchia, G., Hussain, A., Balchandra, S., Coltell, I. B., Perez, J. L., Bohra, A., Awan, A. K., Madhok, B., Leeder, P. C., Awad, S., Al-Khyatt, W., Shoma, A., Elghadban, H., Ghareeb, S., Mathews, B., Kurian, M., Larentzakis, A., Vrakopoulou, G. Z., Albanopoulos, K., Bozdag, A., Lale, A., Kirkil, C., Dincer, M., Bashir, A., Haddad, A., Hijleh, L. A., Zilberstein, B., de Marchi, D. D., Souza, W. P., Broden, C. M., Gislason, H., Shah, K., Ambrosi, A., Pavone, G., Tartaglia, N., Kona, S. L. K., Kalyan, K., Perez, C. E. G., Botero, M. A. F., Covic, A., Timofte, D., Maxim, M., Faraj, D., Tseng, L., Liem, R., Oren, G., Dilektasli, E., Yalcin, I., Almukhtar, H., Hadad, M. A., Mohan, R., Arora, N., Bedi, D., Rives-Lange, C., Chevallier, J. -M., Poghosyan, T., Sebbag, H., Zinai, L., Khaldi, S., Mauchien, C., Mazza, D., Dinescu, G., Rea, B., Perez-Galaz, F., Zavala, L., Besa, A., Curell, A., Balibrea, J. M., Vaz, C., Galindo, L., Silva, N., Caballero, J. L. E., Sebastian, S. O., Marchesini, J. C. D., da Fonseca Pereira, R. A., Sobottka, W. H., Fiolo, F. E., Turchi, M., Coelho, A. C. J., Zacaron, A. L., Barbosa, A., Quinino, R., Menaldi, G., Paleari, N., Martinez-Duartez, P., de Esparza, G. M. A. R., Esteban, V. S., Torres, A., Garcia-Galocha, J. L., Josa, M., Pacheco-Garcia, J. M., Mayo-Ossorio, M. A., Chowbey, P., Soni, V., de Vasconcelos Cunha, H. A., Castilho, M. V., Ferreira, R. M. A., Barreiro, T. A., Charalabopoulos, A., Sdralis, E., Davakis, S., Bomans, B., Dapri, G., Van Belle, K., Takieddine, M., Vaneukem, P., Karaca, E. S. A., Karaca, F. C., Sumer, A., Peksen, C., Savas, O. A., Chousleb, E., Elmokayed, F., Fakhereldin, I., Aboshanab, H. M., Swelium, T., Gudal, A., Gamloo, L., Ugale, A., Ugale, S., Boeker, C., Reetz, C., Hakami, I. A., Mall, J., Alexandrou, A., Baili, E., Bodnar, Z., Maleckas, A., Gudaityte, R., Guldogan, C. E., Gundogdu, E., Ozmen, M. M., Thakkar, D., Dukkipati, N., Shah, P. S., Shah, S. S., Adil, M. T., Jambulingam, P., Mamidanna, R., Whitelaw, D., Jain, V., Veetil, D. K., Wadhawan, R., Torres, M., Tinoco, T., Leclercq, W., Romeijn, M., van de Pas, K., Alkhazraji, A. K., Taha, S. A., Ustun, M., Yigit, T., Inam, A., Burhanulhaq, M., Pazouki, A., Eghbali, F., Kermansaravi, M., Jazi, A. H. D., Mahmoudieh, M., Mogharehabed, N., Tsiotos, G., Stamou, K., Rodriguez, F. J. B., Navarro, M. A. R., Torres, O. M., Martinez, S. L., Tamez, E. R. M., Cornejo, G. A. M., Flores, J. E. G., Mohammed, D. A., Elfawal, M. H., Shabbir, A., Guowei, K., So, J. B., Kaplan, E. T., Kaplan, M., Kaplan, T., Pham, D. T., Rana, G., Kappus, M., Gadani, R., Kahitan, M., Pokharel, K., Osborne, A., Pournaras, D., Hewes, J., Napolitano, E., Chiappetta, S., Bottino, V., Dorado, E., Schoettler, A., Gaertner, D., Fedtke, K., Aguilar-Espinosa, F., Aceves-Lozano, S., Balani, A., Nagliati, C., Pennisi, D., Rizzi, A., Frattini, F., Foschi, D., Benuzzi, L., Parikh, C., Shah, H., Pinotti, E., Montuori, M., Borrelli, V., Dargent, J., Copaescu, C. A., Hutopila, I., Smeu, B., Witteman, B., Hazebroek, E., Deden, L., Heusschen, L., Okkema, S., Aufenacker, T., den Hengst, W., Vening, W., van der Burgh, Y., Ghazal, A., Ibrahim, H., Niazi, M., Alkhaffaf, B., Altarawni, M., Cesana, G. C., Anselmino, M., Uccelli, M., Olmi, S., Stier, C., Akmanlar, T., Sonnenberg, T., Schieferbein, U., Marcolini, A., Awruch, D., Vicentin, M., de Souza Bastos, E. L., Gregorio, S. A., Ahuja, A., Mittal, T., Bolckmans, R., Baratte, C., Wisnewsky, J. A., Genser, L., Chong, L., Taylor, L., Ward, S., Hi, M. W., Heneghan, H., Fearon, N., Plamper, A., Rheinwalt, K., Geoghegan, J., Ng, K. C., Kaseja, K., Kotowski, M., Samarkandy, T. A., Leyva-Alvizo, A., Corzo-Culebro, L., Wang, C., Yang, W., Dong, Z., Riera, M., Jain, R., Hamed, H., Said, M., Zarzar, K., Garcia, M., Turkcapar, A. G., Sen, O., Baldini, E., Conti, L., Wietzycoski, C., Lopes, E., Pintar, T., Salobir, J., Aydin, C., Atici, S. D., Ergin, A., Ciyiltepe, H., Bozkurt, M. A., Kizilkaya, M. C., Onalan, N. B. D., Zuber, M. N. B. A., Wong, W. J., Garcia, A., Vidal, L., Beisani, M., Pasquier, J., Vilallonga, R., Sharma, S., Parmar, C., Lee, L., Sufi, P., Sinan, H., Saydam, M., İstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Sumer, Aziz, Peksen, Caghan, and Savas, Osman Anil

Subjects
Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Gastric Bypass, Medicine (miscellaneous), nutritional and metabolic diseases, COVID-19, Gastrectomy, Humans, Morbidity, Propensity Score, Retrospective Studies, Treatment Outcome, Diabetes Mellitus, Type 2, Obesity, Morbid, Article, Diabetes Mellitus, Obesity, Morbid, Type 2
Abstract

Background There is a paucity of data comparing 30-day morbidity and mortality of sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), and one anastomosis gastric bypass (OAGB). This study aimed to compare the 30-day safety of SG, RYGB, and OAGB in propensity score-matched cohorts. Materials and methods This analysis utilised data collected from the GENEVA study which was a multicentre observational cohort study of bariatric and metabolic surgery (BMS) in 185 centres across 42 countries between 01/05/2022 and 31/10/2020 during the Coronavirus Disease-2019 (COVID-19) pandemic. 30-day complications were categorised according to the Clavien–Dindo classification. Patients receiving SG, RYGB, or OAGB were propensity-matched according to baseline characteristics and 30-day complications were compared between groups. Results In total, 6770 patients (SG 3983; OAGB 702; RYGB 2085) were included in this analysis. Prior to matching, RYGB was associated with highest 30-day complication rate (SG 5.8%; OAGB 7.5%; RYGB 8.0% (p = 0.006)). On multivariate regression modelling, Insulin-dependent type 2 diabetes mellitus and hypercholesterolaemia were associated with increased 30-day complications. Being a non-smoker was associated with reduced complication rates. When compared to SG as a reference category, RYGB, but not OAGB, was associated with an increased rate of 30-day complications. A total of 702 pairs of SG and OAGB were propensity score-matched. The complication rate in the SG group was 7.3% (n = 51) as compared to 7.5% (n = 53) in the OAGB group (p = 0.68). Similarly, 2085 pairs of SG and RYGB were propensity score-matched. The complication rate in the SG group was 6.1% (n = 127) as compared to 7.9% (n = 166) in the RYGB group (p = 0.09). And, 702 pairs of OAGB and RYGB were matched. The complication rate in both groups was the same at 7.5 % (n = 53; p = 0.07). Conclusions This global study found no significant difference in the 30-day morbidity and mortality of SG, RYGB, and OAGB in propensity score-matched cohorts.

Published
2021
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4. 30-Day morbidity and mortality of bariatric metabolic surgery in adolescence during the COVID-19 pandemic – The GENEVA study

Author

Singhal R., Wiggins T., Super J., Alqahtani A., Nadler E. P., Ludwig C., Tahrani A., Mahawar K., Pedziwiatr M., Major P., Zarzycki P., Pantelis A., Lapatsanis D. P., Stravodimos G., Matthys C., Focquet M., Vleeschouwers W., Spaventa A. G., Zerrweck C., Vitiello A., Berardi G., Musella M., Sanchez-Meza A., Cantu F. J., Mora F., Cantu M. A., Katakwar A., Reddy D. N., Elmaleh H., Hassan M., Elghandour A., Elbanna M., Osman A., Khan A., Layani L., Kiran N., Velikorechin A., Solovyeva M., Melali H., Shahabi S., Agrawal A., Shrivastava A., Sharma A., Narwaria B., Narwaria M., Raziel A., Sakran N., Susmallian S., Karagoz L., Akbaba M., Piskin S. Z., Ziya A., Senol Z., Manno E., Iovino M. G., Qassem M., Arana-Garza S., Povoas H. P., Vilas-Boas M. L., Naumann D., Li A., Ammori B. J., Balamoun H., Salman M., Nasta A. M., Goel R., Sanchez-Aguilar H., Herrera M. F., Abou-Mrad A., Cloix L., Mazzini G. S., Kristem L., Lazaro A., Campos J., Bernardo J., Gonzalez J., Trindade C., Viveiros O., Ribeiro R., Goitein D., Hazzan D., Segev L., Beck T., Reyes H., Monterrubio J., Garcia P., Benois M., Kassir R., Contine A., Elshafei M., Aktas S., Weiner S., Heidsieck T., Level L., Pinango S., Ortega P. M., Moncada R., Valenti V., Vlahovic I., Boras Z., Liagre A., Martini F., Juglard G., Motwani M., Saggu S. S., Al Momani H., Lopez L. A. A., Cortez M. A. C., Zavala R. A., D'Haese C., Kempeneers I., Himpens J., Lazzati A., Paolino L., Bathaei S., Bedirli A., Yavuz A., Buyukkasap C., Ozaydin S., Kwiatkowski A., Bartosiak K., Waledziak M., Santonicola A., Angrisani L., Iovino P., Palma R., Iossa A., Boru C. E., De Angelis F., Silecchia G., Hussain A., Balchandra S., Coltell I. B., Perez J. L., Bohra A., Awan A. K., Madhok B., Leeder P. C., Awad S., Al-Khyatt W., Shoma A., Elghadban H., Ghareeb S., Mathews B., Kurian M., Larentzakis A., Vrakopoulou G. Z., Albanopoulos K., Bozdag A., Lale A., Kirkil C., Dincer M., Bashir A., Haddad A., Hijleh L. A., Zilberstein B., de Marchi D. D., Souza W. P., Broden C. M., Gislason H., Shah K., Ambrosi A., Pavone G., Tartaglia N., Kona S. L. K., Kalyan K., Perez C. E. G., Botero M. A. F., Covic A., Timofte D., Maxim M., Faraj D., Tseng L., Liem R., Oren G., Dilektasli E., Yalcin I., AlMukhtar H., Al Hadad M., Mohan R., Arora N., Bedi D., Rives-Lange C., Chevallier J. -M., Poghosyan T., Sebbag H., Zinai L., Khaldi S., Mauchien C., Mazza D., Dinescu G., Rea B., Perez-Galaz F., Zavala L., Besa A., Curell A., Balibrea J. M., Vaz C., Galindo L., Silva N., Caballero J. L. E., Sebastian S. O., Marchesini J. C. D., da Fonseca Pereira R. A., Sobottka W. H., Fiolo F. E., Turchi M., Coelho A. C. J., Zacaron A. L., Barbosa A., Quinino R., Menaldi G., Paleari N., Martinez-Duartez P., Aragon Ramirez de Esparza D. G. M., Esteban V. S., Torres A., Garcia-Galocha J. L., Josa M. I., Pacheco-Garcia J. M., Mayo-Ossorio M. A., Chowbey P., Soni V., de Vasconcelos Cunha H. A., Castilho M. V., Ferreira R. M. A., Barreiro T. A., Charalabopoulos A., Sdralis E., Davakis S., Bomans B., Dapri G., Van Belle K., MazenTakieddine, Vaneukem P., Karaca E. S. A., Karaca F. C., Sumer A., Peksen C., Savas O. A., Chousleb E., Elmokayed F., Fakhereldin I., Aboshanab H. M., Swelium T., Gudal A., Gamloo L., Ugale A., Ugale S., Boeker C., Reetz C., Hakami I. A., Mall J., Alexandrou A., Baili E., Bodnar Z., Maleckas A., Gudaityte R., Guldogan C. E., Gundogdu E., Ozmen M. M., Thakkar D., Dukkipati N., Shah P. S., Shah S. S., Adil M. T., Jambulingam P., Mamidanna R., Whitelaw D., Jain V., Veetil D. K., Wadhawan R., Torres M., Tinoco T., Leclercq W., Romeijn M., van de Pas K., Alkhazraji A. K., Taha S. A., Ustun M., Yigit T., Inam A., Burhanulhaq M., Pazouki A., Eghbali F., Kermansaravi M., Jazi A. H. D., Mahmoudieh M., Mogharehabed N., Tsiotos G., Stamou K., Barrera Rodriguez F. J., Rojas Navarro M. A., Torres O. M. O., Martinez S. L., Tamez E. R. M., Millan Cornejo G. A., Flores J. E. G., Mohammed D. A., Elfawal M. H., Shabbir A., Guowei K., So J. B. Y., Kaplan E. T., Kaplan M., Kaplan T., Pham D. T., Rana G., Kappus M., Gadani R., Kahitan M., Pokharel K., Osborne A., Pournaras D., Hewes J., Napolitano E., Chiappetta S., Bottino V., Dorado E., Schoettler A., Gaertner D., Fedtke K., Aguilar-Espinosa F., Aceves-Lozano S., Balani A., Nagliati C., Pennisi D., Rizzi A., Frattini F., Foschi D., Benuzzi L., Parikh C. H. I. R. A. G., Shah H. A. R. S. H. I. L., Pinotti E., Montuori M., Borrelli V., Dargent J., Copaescu C. A., Hutopila I., Smeu B., Witteman B., Hazebroek E., Deden L., Heusschen L., Okkema S., Aufenacker T., den Hengst W., Vening W., van der Burgh Y., Ghazal A., Ibrahim H., Niazi M., Alkhaffaf B., Altarawni M., Cesana G. C., Anselmino M., Uccelli M., Olmi S., Stier C., Akmanlar T., Sonnenberg T., Schieferbein U., Marcolini A., Awruch D., Vicentin M., de Souza Bastos E. L., Gregorio S. A., Ahuja A., Mittal T., Bolckmans R., Baratte C., Wisnewsky J. A., Genser L., Chong L., Taylor L., Ward S., Hi M. W., Heneghan H., Fearon N., Plamper A., Rheinwalt K., Geoghegan J., Ng K. C., Kaseja K., Kotowski M., Samarkandy T. A., Leyva-Alvizo A., Corzo-Culebro L., Wang C., Yang W., Dong Z., Riera M., Jain R., Hamed H., Said M., Zarzar K., Garcia M., Turkcapar A. G., Sen O., Baldini E., Conti L., Wietzycoski C., Lopes E., Pintar T., Salobir J., Aydin C., Atici S. D., Ergin A., Ciyiltepe H., Bozkurt M. A., Kizilkaya M. C., Onalan N. B. D., Zuber M. N. B. A., Wong W. J., Garcia A., Vidal L., Beisani M., Pasquier J., Vilallonga R., Sharma S., Parmar C., Lee L., Sufi P., Sinan H., Saydam M., Singhal, R., Wiggins, T., Super, J., Alqahtani, A., Nadler, E. P., Ludwig, C., Tahrani, A., Mahawar, K., Pedziwiatr, M., Major, P., Zarzycki, P., Pantelis, A., Lapatsanis, D. P., Stravodimos, G., Matthys, C., Focquet, M., Vleeschouwers, W., Spaventa, A. G., Zerrweck, C., Vitiello, A., Berardi, G., Musella, M., Sanchez-Meza, A., Cantu, F. J., Mora, F., Cantu, M. A., Katakwar, A., Reddy, D. N., Elmaleh, H., Hassan, M., Elghandour, A., Elbanna, M., Osman, A., Khan, A., Layani, L., Kiran, N., Velikorechin, A., Solovyeva, M., Melali, H., Shahabi, S., Agrawal, A., Shrivastava, A., Sharma, A., Narwaria, B., Narwaria, M., Raziel, A., Sakran, N., Susmallian, S., Karagoz, L., Akbaba, M., Piskin, S. Z., Ziya, A., Senol, Z., Manno, E., Iovino, M. G., Qassem, M., Arana-Garza, S., Povoas, H. P., Vilas-Boas, M. L., Naumann, D., Li, A., Ammori, B. J., Balamoun, H., Salman, M., Nasta, A. M., Goel, R., Sanchez-Aguilar, H., Herrera, M. F., Abou-Mrad, A., Cloix, L., Mazzini, G. S., Kristem, L., Lazaro, A., Campos, J., Bernardo, J., Gonzalez, J., Trindade, C., Viveiros, O., Ribeiro, R., Goitein, D., Hazzan, D., Segev, L., Beck, T., Reyes, H., Monterrubio, J., Garcia, P., Benois, M., Kassir, R., Contine, A., Elshafei, M., Aktas, S., Weiner, S., Heidsieck, T., Level, L., Pinango, S., Ortega, P. M., Moncada, R., Valenti, V., Vlahovic, I., Boras, Z., Liagre, A., Martini, F., Juglard, G., Motwani, M., Saggu, S. S., Al Momani, H., Lopez, L. A. A., Cortez, M. A. C., Zavala, R. A., D'Haese, C., Kempeneers, I., Himpens, J., Lazzati, A., Paolino, L., Bathaei, S., Bedirli, A., Yavuz, A., Buyukkasap, C., Ozaydin, S., Kwiatkowski, A., Bartosiak, K., Waledziak, M., Santonicola, A., Angrisani, L., Iovino, P., Palma, R., Iossa, A., Boru, C. E., De Angelis, F., Silecchia, G., Hussain, A., Balchandra, S., Coltell, I. B., Perez, J. L., Bohra, A., Awan, A. K., Madhok, B., Leeder, P. C., Awad, S., Al-Khyatt, W., Shoma, A., Elghadban, H., Ghareeb, S., Mathews, B., Kurian, M., Larentzakis, A., Vrakopoulou, G. Z., Albanopoulos, K., Bozdag, A., Lale, A., Kirkil, C., Dincer, M., Bashir, A., Haddad, A., Hijleh, L. A., Zilberstein, B., de Marchi, D. D., Souza, W. P., Broden, C. M., Gislason, H., Shah, K., Ambrosi, A., Pavone, G., Tartaglia, N., Kona, S. L. K., Kalyan, K., Perez, C. E. G., Botero, M. A. F., Covic, A., Timofte, D., Maxim, M., Faraj, D., Tseng, L., Liem, R., Oren, G., Dilektasli, E., Yalcin, I., Almukhtar, H., Al Hadad, M., Mohan, R., Arora, N., Bedi, D., Rives-Lange, C., Chevallier, J. -M., Poghosyan, T., Sebbag, H., Zinai, L., Khaldi, S., Mauchien, C., Mazza, D., Dinescu, G., Rea, B., Perez-Galaz, F., Zavala, L., Besa, A., Curell, A., Balibrea, J. M., Vaz, C., Galindo, L., Silva, N., Caballero, J. L. E., Sebastian, S. O., Marchesini, J. C. D., da Fonseca Pereira, R. A., Sobottka, W. H., Fiolo, F. E., Turchi, M., Coelho, A. C. J., Zacaron, A. L., Barbosa, A., Quinino, R., Menaldi, G., Paleari, N., Martinez-Duartez, P., Aragon Ramirez de Esparza, D. G. M., Esteban, V. S., Torres, A., Garcia-Galocha, J. L., Josa, M. I., Pacheco-Garcia, J. M., Mayo-Ossorio, M. A., Chowbey, P., Soni, V., de Vasconcelos Cunha, H. A., Castilho, M. V., Ferreira, R. M. A., Barreiro, T. A., Charalabopoulos, A., Sdralis, E., Davakis, S., Bomans, B., Dapri, G., Van Belle, K., Mazentakieddine, Vaneukem, P., Karaca, E. S. A., Karaca, F. C., Sumer, A., Peksen, C., Savas, O. A., Chousleb, E., Elmokayed, F., Fakhereldin, I., Aboshanab, H. M., Swelium, T., Gudal, A., Gamloo, L., Ugale, A., Ugale, S., Boeker, C., Reetz, C., Hakami, I. A., Mall, J., Alexandrou, A., Baili, E., Bodnar, Z., Maleckas, A., Gudaityte, R., Guldogan, C. E., Gundogdu, E., Ozmen, M. M., Thakkar, D., Dukkipati, N., Shah, P. S., Shah, S. S., Adil, M. T., Jambulingam, P., Mamidanna, R., Whitelaw, D., Jain, V., Veetil, D. K., Wadhawan, R., Torres, M., Tinoco, T., Leclercq, W., Romeijn, M., van de Pas, K., Alkhazraji, A. K., Taha, S. A., Ustun, M., Yigit, T., Inam, A., Burhanulhaq, M., Pazouki, A., Eghbali, F., Kermansaravi, M., Jazi, A. H. D., Mahmoudieh, M., Mogharehabed, N., Tsiotos, G., Stamou, K., Barrera Rodriguez, F. J., Rojas Navarro, M. A., Torres, O. M. O., Martinez, S. L., Tamez, E. R. M., Millan Cornejo, G. A., Flores, J. E. G., Mohammed, D. A., Elfawal, M. H., Shabbir, A., Guowei, K., So, J. B. Y., Kaplan, E. T., Kaplan, M., Kaplan, T., Pham, D. T., Rana, G., Kappus, M., Gadani, R., Kahitan, M., Pokharel, K., Osborne, A., Pournaras, D., Hewes, J., Napolitano, E., Chiappetta, S., Bottino, V., Dorado, E., Schoettler, A., Gaertner, D., Fedtke, K., Aguilar-Espinosa, F., Aceves-Lozano, S., Balani, A., Nagliati, C., Pennisi, D., Rizzi, A., Frattini, F., Foschi, D., Benuzzi, L., Parikh, C. H. I. R. A. G., Shah, H. A. R. S. H. I. L., Pinotti, E., Montuori, M., Borrelli, V., Dargent, J., Copaescu, C. A., Hutopila, I., Smeu, B., Witteman, B., Hazebroek, E., Deden, L., Heusschen, L., Okkema, S., Aufenacker, T., den Hengst, W., Vening, W., van der Burgh, Y., Ghazal, A., Ibrahim, H., Niazi, M., Alkhaffaf, B., Altarawni, M., Cesana, G. C., Anselmino, M., Uccelli, M., Olmi, S., Stier, C., Akmanlar, T., Sonnenberg, T., Schieferbein, U., Marcolini, A., Awruch, D., Vicentin, M., de Souza Bastos, E. L., Gregorio, S. A., Ahuja, A., Mittal, T., Bolckmans, R., Baratte, C., Wisnewsky, J. A., Genser, L., Chong, L., Taylor, L., Ward, S., Hi, M. W., Heneghan, H., Fearon, N., Plamper, A., Rheinwalt, K., Geoghegan, J., Ng, K. C., Kaseja, K., Kotowski, M., Samarkandy, T. A., Leyva-Alvizo, A., Corzo-Culebro, L., Wang, C., Yang, W., Dong, Z., Riera, M., Jain, R., Hamed, H., Said, M., Zarzar, K., Garcia, M., Turkcapar, A. G., Sen, O., Baldini, E., Conti, L., Wietzycoski, C., Lopes, E., Pintar, T., Salobir, J., Aydin, C., Atici, S. D., Ergin, A., Ciyiltepe, H., Bozkurt, M. A., Kizilkaya, M. C., Onalan, N. B. D., Zuber, M. N. B. A., Wong, W. J., Garcia, A., Vidal, L., Beisani, M., Pasquier, J., Vilallonga, R., Sharma, S., Parmar, C., Lee, L., Sufi, P., Sinan, H., and Saydam, M.

Subjects
Male, Pediatrics, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Adolescent, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), bariatric surgery, Context (language use), Pandemic, Medicine, Humans, Pandemics, COVID-19, pandemic, SARS-CoV-2, Nutrition and Dietetics, Manchester Cancer Research Centre, business.industry, Health Policy, ResearchInstitutes_Networks_Beacons/mcrc, Public Health, Environmental and Occupational Health, medicine.disease, Obesity, Obesity, Morbid, Treatment Outcome, Pediatrics, Perinatology and Child Health, Cohort, Female, Morbidity, business, Body mass index, Cohort study, Human
Abstract

Background: Metabolic and bariatric surgery (MBS) is an effective treatment for adolescents with severe obesity. Objectives: This study examined the safety of MBS in adolescents during the coronavirus disease 2019 (COVID-19) pandemic. Methods: This was a global, multicentre and observational cohort study of MBS performed between May 01, 2020, and October 10,2020, in 68 centres from 24 countries. Data collection included in-hospital and 30-day COVID-19 and surgery-specific morbidity/mortality. Results: One hundred and seventy adolescent patients (mean age: 17.75 ± 1.30 years), mostly females (n=122, 71.8%), underwent MBS during the study period. The mean pre-operative weight and body mass index were 122.16 ± 15.92 kg and 43.7± 7.11 kg/m2, respectively. Although majority of patients had pre-operative testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (n=146; 85.9%), only 42.4% (n=72) of the patients were asked to self-isolate pre-operatively. Two patients developed symptomatic SARS-CoV-2 infection post-operatively (1.2%). The overall complication rate was 5.3% (n=9). There was no mortality in this cohort. Conclusions: MBS in adolescents with obesity is safe during the COVID-19 pandemic when performed within the context of local precautionary procedures (such as pre-operative testing). The 30-day morbidity rates were similar to those reported pre-pandemic. These data will help facilitate the safe re-introduction of MBS services for this group of patients.

Published
2021
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5. Efficacy and safety of atacicept for prevention of flares in patients with moderate-to-severe systemic lupus erythematosus (SLE): 52-week data (APRIL-SLE randomised trial)

Author

Isenberg, David, Gordon, Caroline, Licu, Daiana, Copt, Samuel, Rossi, Claudia Pena, Wofsy, David, Babini, A, Lazaro, M, Lucero, E, Merono, C, Rillo, O, Spindler, A, Tate, G, Velasco Zamora, B, Bossingham, D, Littlejohn, G, Nicholls, D, Reeves, G, Rischmueller, M, Zamani, O, Sato, E, Scheinberg, M, Zerbini, C, Rashkov, R, Glasnovic, M, Martinovic-Kaliterna, D, Morovic-Vergles, J, Novak, S, Tegzova, D, Vavrincova, P, Amoura, Z, Carle, P, Hachulla, E, Jorgensen, C, Sibilia, J, Viallard, J, Braun, J, Hiepe, F, Kuhn, A, Lorenz, H, Schmidt, R, Schulze-Koops, H, Wacker, J, Settas, L, Mouli Veeravalli, S, Balbir-Gurman, A, Langevitz, P, Mevorach, D, Molad, Y, Bae, S, Cho, CS, Kim, HY, Suh, C, Andersone, D, Ziade, N, Baranauskaite, A, Stropuviene, S, Gun, S, Kong, N, Sulaiman, W, Ramos Remus, C, Saldate Alonso, C, Huizinga, T, Tak, P, van Paassen, P, Arroyo, C, Gomez, H, Perez, E, Ramiterre, E, Salido, E, Brzosko, M, Chudzik, D, Dyczek, A, Jeka, S, Sierakowski, S, Zdrojewski, Z, Barbarash, O, Ershova, O, Gordienko, A, Lomareva, N, Shvarts, Y, Sorotskaya, V, Vezikova, N, Yakushin, S, Bogic, M, Dimic, A, Damjanov, N, Petrovic, R, Stojanovic, L, Kalla, A, Louw, I, Nayiager, S, Reuter, H, Spargo, C, Whitelaw, D, Carbonell Abello, J, Fernandez Nebro, A, Gomez Reino, J, Lopez Longo, F, von Kempis, J, Huang, CM, Lan, JL, Lin, HY, Liou, LB, Bruce, I, Tahir, H, Abrahamovych, O, Dyadyk, O, Nikirenkov, Y, Rudyk, Y, Smiyan, S, Stanislavchuk, M, Ter-Vartanyan, S, Aranow, C, Askanase, A, Chakravarty, E, Chatham, W, Clark, M, Dhar, P, Dikranian, A, Fiechtner, J, Ginzler, E, Harmon, C, Knibbe, W, Lee, E, Lockshin, M, Luggen, M, Massarotti, E, Mitri, G, Peng, S, and Singer, N

Published
2015
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7. 30-day morbidity and mortality of sleeve gastrectomy, Roux-en-Y gastric bypass and one anastomosis gastric bypass: a propensity score-matched analysis of the GENEVA data

Author

Singhal, R. Cardoso, V.R. Wiggins, T. Super, J. Ludwig, C. Gkoutos, G.V. Mahawar, K. Pędziwiatr, M. Major, P. Zarzycki, P. Pantelis, A. Lapatsanis, D.P. Stravodimos, G. Matthys, C. Focquet, M. Vleeschouwers, W. Spaventa, A.G. Zerrweck, C. Vitiello, A. Berardi, G. Musella, M. Sanchez-Meza, A. Cantu, F.J., Jr Mora, F. Cantu, M.A. Katakwar, A. Reddy, D.N. Elmaleh, H. Hassan, M. Elghandour, A. Elbanna, M. Osman, A. Khan, A. layani, L. Kiran, N. Velikorechin, A. Solovyeva, M. Melali, H. Shahabi, S. Agrawal, A. Shrivastava, A. Sharma, A. Narwaria, B. Narwaria, M. Raziel, A. Sakran, N. Susmallian, S. Karagöz, L. Akbaba, M. Pişkin, S.Z. Balta, A.Z. Senol, Z. Manno, E. Iovino, M.G. Osman, A. Qassem, M. Arana-Garza, S. Povoas, H.P. Vilas-Boas, M.L. Naumann, D. Li, A. Ammori, B.J. Balamoun, H. Salman, M. Nasta, A.M. Goel, R. Sánchez-Aguilar, H. Herrera, M.F. Abou-mrad, A. Cloix, L. Mazzini, G.S. Kristem, L. Lazaro, A. Campos, J. Bernardo, J. González, J. Trindade, C. Viveiros, O. Ribeiro, R. Goitein, D. Hazzan, D. Segev, L. Beck, T. Reyes, H. Monterrubio, J. García, P. Benois, M. Kassir, R. Contine, A. Elshafei, M. Aktas, S. Weiner, S. Heidsieck, T. Level, L. Pinango, S. Ortega, P.M. Moncada, R. Valenti, V. Vlahović, I. Boras, Z. Liagre, A. Martini, F. Juglard, G. Motwani, M. Saggu, S.S. Momani, H.A. López, L.A.A. Cortez, M.A.C. Zavala, R.A. D’Haese RN, C. Kempeneers, I. Himpens, J. Lazzati, A. Paolino, L. Bathaei, S. Bedirli, A. Yavuz, A. Büyükkasap, Ç. Özaydın, S. Kwiatkowski, A. Bartosiak, K. Walędziak, M. Santonicola, A. Angrisani, L. Iovino, P. Palma, R. Iossa, A. Boru, C.E. De Angelis, F. Silecchia, G. Hussain, A. Balchandra, S. Coltell, I.B. Pérez, J.L. Bohra, A. Awan, A.K. Madhok, B. Leeder, P.C. Awad, S. Al-Khyatt, W. Shoma, A. Elghadban, H. Ghareeb, S. Mathews, B. Kurian, M. Larentzakis, A. Vrakopoulou, G.Z. Albanopoulos, K. Bozdag, A. Lale, A. Kirkil, C. Dincer, M. Bashir, A. Haddad, A. Hijleh, L.A. Zilberstein, B. de Marchi, D.D. Souza, W.P. Brodén, C.M. Gislason, H. Shah, K. Ambrosi, A. Pavone, G. Tartaglia, N. Kona, S.L.K. Kalyan, K. Perez, C.E.G. Botero, M.A.F. Covic, A. Timofte, D. Maxim, M. Faraj, D. Tseng, L. Liem, R. Ören, G. Dilektasli, E. Yalcin, I. AlMukhtar, H. Hadad, M.A. Mohan, R. Arora, N. Bedi, D. Rives-Lange, C. Chevallier, J.-M. Poghosyan, T. Sebbag, H. Zinaï, L. Khaldi, S. Mauchien, C. Mazza, D. Dinescu, G. Rea, B. Pérez-Galaz, F. Zavala, L. Besa, A. Curell, A. Balibrea, J.M. Vaz, C. Galindo, L. Silva, N. Caballero, J.L.E. Sebastian, S.O. Marchesini, J.C.D. da Fonseca Pereira, R.A. Sobottka, W.H. Fiolo, F.E. Turchi, M. Coelho, A.C.J. Zacaron, A.L. Barbosa, A. Quinino, R. Menaldi, G. Paleari, N. Martinez-Duartez, P. de Esparza, G.M.A.R. Esteban, V.S. Torres, A. Garcia-Galocha, J.L. Josa, M. Pacheco-Garcia, J.M. Mayo-Ossorio, M.A. Chowbey, P. Soni, V. de Vasconcelos Cunha, H.A. Castilho, M.V. Ferreira, R.M.A. Barreiro, T.A. Charalabopoulos, A. Sdralis, E. Davakis, S. Bomans, B. Dapri, G. Van Belle, K. Takieddine, M. Vaneukem, P. Karaca, E.S.A. Karaca, F.C. Sumer, A. Peksen, C. Savas, O.A. Chousleb, E. Elmokayed, F. Fakhereldin, I. Aboshanab, H.M. Swelium, T. Gudal, A. Gamloo, L. Ugale, A. Ugale, S. Boeker, C. Reetz, C. Hakami, I.A. Mall, J. Alexandrou, A. Baili, E. Bodnar, Z. Maleckas, A. Gudaityte, R. Guldogan, C.E. Gundogdu, E. Ozmen, M.M. Thakkar, D. Dukkipati, N. Shah, P.S. Shah, S.S. Shah, S.S. Adil, M.T. Jambulingam, P. Mamidanna, R. Whitelaw, D. Adil, M.T. Jain, V. Veetil, D.K. Wadhawan, R. Torres, A. Torres, M. Tinoco, T. Leclercq, W. Romeijn, M. van de Pas, K. Alkhazraji, A.K. Taha, S.A. Ustun, M. Yigit, T. Inam, A. Burhanulhaq, M. Pazouki, A. Eghbali, F. Kermansaravi, M. Jazi, A.H.D. Mahmoudieh, M. Mogharehabed, N. Tsiotos, G. Stamou, K. Rodriguez, F.J.B. Navarro, M.A.R. Torres, O.M. Martinez, S.L. Tamez, E.R.M. Cornejo, G.A.M. Flores, J.E.G. Mohammed, D.A. Elfawal, M.H. Shabbir, A. Guowei, K. So, J.B. Kaplan, E.T. Kaplan, M. Kaplan, T. Pham, D.T. Rana, G. Kappus, M. Gadani, R. Kahitan, M. Pokharel, K. Osborne, A. Pournaras, D. Hewes, J. Napolitano, E. Chiappetta, S. Bottino, V. Dorado, E. Schoettler, A. Gaertner, D. Fedtke, K. Aguilar-Espinosa, F. Aceves-Lozano, S. Balani, A. Nagliati, C. Pennisi, D. Rizzi, A. Frattini, F. Foschi, D. Benuzzi, L. Parikh, C. Shah, H. Pinotti, E. Montuori, M. Borrelli, V. Dargent, J. Copaescu, C.A. Hutopila, I. Smeu, B. Witteman, B. Hazebroek, E. Deden, L. Heusschen, L. Okkema, S. Aufenacker, T. den Hengst, W. Vening, W. van der Burgh, Y. Ghazal, A. Ibrahim, H. Niazi, M. Alkhaffaf, B. Altarawni, M. Cesana, G.C. Anselmino, M. Uccelli, M. Olmi, S. Stier, C. Akmanlar, T. Sonnenberg, T. Schieferbein, U. Marcolini, A. Awruch, D. Vicentin, M. de Souza Bastos, E.L. Gregorio, S.A. Ahuja, A. Mittal, T. Bolckmans, R. Wiggins, T. Baratte, C. Wisnewsky, J.A. Genser, L. Chong, L. Taylor, L. Ward, S. Hi, M.W. Heneghan, H. Fearon, N. Plamper, A. Rheinwalt, K. Heneghan, H. Geoghegan, J. Ng, K.C. Fearon, N. Kaseja, K. Kotowski, M. Samarkandy, T.A. Leyva-Alvizo, A. Corzo-Culebro, L. Wang, C. Yang, W. Dong, Z. Riera, M. Jain, R. Hamed, H. Said, M. Zarzar, K. Garcia, M. Türkçapar, A.G. Şen, O. Baldini, E. Conti, L. Wietzycoski, C. Lopes, E. Pintar, T. Salobir, J. Aydin, C. Atici, S.D. Ergin, A. Ciyiltepe, H. Bozkurt, M.A. Kizilkaya, M.C. Onalan, N.B.D. Zuber, M.N.B.A. Wong, W.J. Garcia, A. Vidal, L. Beisani, M. Pasquier, J. Vilallonga, R. Sharma, S. Parmar, C. Lee, L. Sufi, P. Sinan, H. Saydam, M. GENEVA Collaborators

Subjects
nutritional and metabolic diseases
Abstract

Background: There is a paucity of data comparing 30-day morbidity and mortality of sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), and one anastomosis gastric bypass (OAGB). This study aimed to compare the 30-day safety of SG, RYGB, and OAGB in propensity score-matched cohorts. Materials and methods: This analysis utilised data collected from the GENEVA study which was a multicentre observational cohort study of bariatric and metabolic surgery (BMS) in 185 centres across 42 countries between 01/05/2022 and 31/10/2020 during the Coronavirus Disease-2019 (COVID-19) pandemic. 30-day complications were categorised according to the Clavien–Dindo classification. Patients receiving SG, RYGB, or OAGB were propensity-matched according to baseline characteristics and 30-day complications were compared between groups. Results: In total, 6770 patients (SG 3983; OAGB 702; RYGB 2085) were included in this analysis. Prior to matching, RYGB was associated with highest 30-day complication rate (SG 5.8%; OAGB 7.5%; RYGB 8.0% (p = 0.006)). On multivariate regression modelling, Insulin-dependent type 2 diabetes mellitus and hypercholesterolaemia were associated with increased 30-day complications. Being a non-smoker was associated with reduced complication rates. When compared to SG as a reference category, RYGB, but not OAGB, was associated with an increased rate of 30-day complications. A total of 702 pairs of SG and OAGB were propensity score-matched. The complication rate in the SG group was 7.3% (n = 51) as compared to 7.5% (n = 53) in the OAGB group (p = 0.68). Similarly, 2085 pairs of SG and RYGB were propensity score-matched. The complication rate in the SG group was 6.1% (n = 127) as compared to 7.9% (n = 166) in the RYGB group (p = 0.09). And, 702 pairs of OAGB and RYGB were matched. The complication rate in both groups was the same at 7.5 % (n = 53; p = 0.07). Conclusions: This global study found no significant difference in the 30-day morbidity and mortality of SG, RYGB, and OAGB in propensity score-matched cohorts. © 2021, The Author(s).

Published
2021

26. Sphingolipids and deoxysphingolipids in diabetes

Author

Schofield, J.D., primary, Steiner, R., additional, Liu, Y., additional, Hobkirk, J., additional, Siahmansur, T., additional, Pemberton, P., additional, Azmi, S., additional, Alecu, I., additional, Whitelaw, D., additional, Carroll, S., additional, von Eckardstein, A., additional, Hornemann, T., additional, and Soran, H., additional

Published
2016
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29. Rationale, design, and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome, a long-term cardiovascular end point trial of lixisenatide versus placebo

Author

UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, Bentley-Lewis, R., Aguilar, D., Riddle, M.C., Claggett, B., Diaz, R., Dickstein, K., Gerstein, H.C., Johnston, P., Køber, L.V., Lawson, F., Lewis, E.F., Maggioni, A.P., McMurray, J.J.V., Ping, L., Probstfield, J.L., Solomon, S.D., Tardif, J.-C., Wu, Y., Pfeffer, M.A., Barkoudah, E., Brahimi, A., Charytan, D., Finn, P., Flynn, A., Hartley, L.H., Henderson, G., Joseph, J., Odutayo, K., Rajesh, V., Vazir, A., Weinrauch, L., Del Prato, S., Petrie, J., Kaplan, A., Lieberman, P., Zuraw, B.L., O'Reilly, E., Patel, K., Allen, P., Scarpa, A., Schattner, M., Granger, C., Rouleau, J., DeMets, D., Chaturvedi, N., Raccah, D., Aizenberg, D., Alvarez, C., Alvarisqueta, A., Baccaro, C., Bartolacci, I., Bordonava, A., Bustamante Labarta, M., Caccavo, A., Calella, P., Cantero, M., Codutti, R., Commendatore, V., Costamagna, O., Cuello, J., Fernandez, A., Garcia Duran, R., Gomez Vilamajo, O., Gorban De Lapertosa, S., Grinfeld, D., Hermida, S., Lagrutta, M., Leon De La Fuente, R., Licheri, A., Luciardi, H., Mackinnon, I., Maffei, L., Marino, J., Montaña, O., Novaretto, L., Orio, S., Orlandini, A., Oviedo, A., Pérez Manghi, F., Patocchi, C., Ramos, H., Rolandi, F., Saa Zarandon, R., Saavedra, S.S., Schiavi, L., Schygiel, P., Trivi, M., Ulla, M., Urdiales, P., Vallejos, J., Vico, M., Waisman, F., Amerena, J., Paul, V., Sangla, K., Van Gaal, W., Yeap, B., Fasching, P., Pieber, T., Danilova, L., Mitkovskaya, N., Sudzhaeva, S., Mathieu, C., Pouleur, Anne-Catherine, Botelho, R.V., Cerqueira, M.J., Chacra, A., Dos Santos, F., Feitosa, G., Forti, A., Golbert, M., Halpern, A., Hissa, M., Lisboa, H., Moraes, J., Nery, M., Quadros, A., Raduan, R., Reis, G., Ribeiro Filho, F., Rollin, G., Rossi, P., Santos, E., Sgarbi, J., Souza, J., Souza, M.R., Delchev, A., Ivanov, V., Klyuchkova, N., Kyoleyan, M., Levterov, G., Lucheva, M., Raev, D., Shumkova, R., Tokmakova, M., Tzekova, M., Yordanov, V., Bailey, G., Bertrand, O., Bhargava, R., Burton, J., Campeau, J., Dumas, R., Filteau, P., Syan, G., Syan, R., Tsoukas, G., Warnica, J.W., Acuña, S., Araneda, G., Bunster, L., Cobos, L., Corbalán, R., Dussaillant, G., Eggers, G., Florenzano, F., Godoy, G., Huidobro, L.A., Lahsen, R., Lanas, F., Larenas, G., Manriquez, L., Medina, M., Palma, J.C., Perez, L., Potthoff, S., Raffo, C., Reyes, E., Saavedra, V., Sanhueza, P., Sepulveda, P., Solis, C.L., Soto, N., Torres, C., Westerberg, B., Yañez, M., Chen, L., Dong, Y., Du, J., Guo, X., Han, P., Hu, T., Jiang, B., Ke, Y., Li, Z., Lu, J., Ma, C., Peng, Y., Shi, Y., Su, G., Tang, B., Xu, B., Yang, J., Yang, Y., Accini, J.L., Arteaga, J.M., Botero, R., Castillo, G., Coronel, J., Cure, C., Garcia, H., Garcia, L., Gomez, C., Hernandez Triana, E., Hernandez, H., Lopez, M., Lopez, P., Manzur, F., Molina, D., Rodriguez, J., Sanchez Vallejo, G., Yupanqui, H., Bronnum-Schou, J., Kaiser Nielsen, P., Nielsen, H., Rønne, H., Rasmussen, S., Rungby, J., Skagen, K., Thomsen, K.K., Torp-Pedersen, C., Duarte-Vera, Y., Marmol Alvear, R., Peñaherrera-Patiño, C., Assaad, S., Shelbaya, S., Ambos, A., Jakovlev, U., Lubi, M., Märtsin, K., Rosenthal, S., Vides, H., Alanko, J., Korsoff, P., Koski, A.-M., Lahtela, J., Nelimarkka, L., Tuomilehto, J., Cariou, B., Catargi, B., Ducloux, R., Hadjadj, S., Kerlan, V., Malecot, J.-M., Petit, C., Rodier, M., Chumburidze, V., Glonti, S., Lominadze, Z., Todua, F., Contzen, C., Marck, C., Fischer, H., Hagenow, A., Himpel-Bönninghoff, A., Kihm, L., Killat, H., Kleinertz, K., Kosch, C., Kreutzmann, K., Lappo, M., Mertes, B., Piechatzek, R., Prohaska, M., Rinke, A., Schellenberg, D., Toursarkissian, N., Arango, J., Gonzalez, R., Granados, A., Herrera, M., Montenegro, P., Munoz, R., Rodriguez, E., Turcios, E., Villalobos, R., Wyss, F., Hatterjee, S., Chopda, M., Chopra, V., Deshpande, N., Dutta, R., Dwivedi, S., Gandhi, P., Gupta, S.K., Gupta, J.B., Gupta, S., Hiregouder, N., Jha, S., Joshi, A., Khan, N., Kumbla, M., Magdum, M., Murthy, K., Prabhu, M., Sahay, R., Sethuraman, S., Shah, N., Shamanna, P., Singh, K.S., Singh, P., Somasekharan, A., Sreenivasamurthy, L., Supe, P., Adawi, F., Atar, S., Cohen, O., Efrati, S., Karnieli, E., Klainman, E., Minuchin, O., Mosenzon, O., Stern, N., Turgeman, Y., Wainstein, J., Aimaretti, G., Berra, C., Ciardullo, A.V., Consoli, A., Cucinotta, D., Di Marco, S., Giorda, C., Giordano, C., Mannucci, E., Orsi, E., Piatti, P., Pontiroli, A., Ponzani, P., Pozzilli, P., Rivellese, A., Akahori, H., Eki, Y., Fujii, K., Hata, Y., Himeno, H., Hirayama, A., Kishimoto, I., Kobayashi, Y., Miyaoka, H., Niiya, T., Nishi, Y., Nozaki, A., Nunohiro, T., Saito, T., Satoh, Y., Takahashi, A., Takahashi, J., Takase, H., Takase, S., Tsuboko, Y., Tsujimoto, M., Tsujino, M., Tsuzuki, M., Watanabe, S., Yamada, T., Chung, W.J., Rim, S., Jang, H., Kim, U., Chung, C.H., Shin, S.-H., Kim, K., Kim, J., Rha, S., Lee, N.H., Kim, C.-J., Park, K.S., Amolina, I., Ducena, K., Helda, R., Konrade, I., Pirags, V., Sime, I., Sokolova, J., Kakariekiene, V., Kavaliauskiene, R., Petrulioniene, Z., Sakalyte, G., Urboniene, A., Zarankiene, R., Uribe, M., Garcia-Hernandez, P., Garza, J., Vazquez-Garcia, A., Gonzalez, J.G., Escalante, M., Zavala, A., Bayram, E., Hernandez-Muñuzuri, J., Ramos, Lopez, G.A., Lujan, J., Garcia-Soria, M., Velasco-Sanchez, R., Rodriguez, I., Jimenez, S., Galeana, C., Lara, S., Garcia-Castillo, A., Castro, M.G., Aguilar-Orozco, R., Lopez Rosas, E., Vidrio, M., Llamas, G., Stobschinski De Alba, C.A., Carranza-Madrigal, J., Cardosa-Torres, F., Cornel, J.H., Dekkers, P., Frederiks, J., Hermans, W., Lok, D., Meeder, J., Nierop, P., Cooper, J., Lappegård, K.T., Nedrebø, B.G., Castro, E., Gonzalez Castillo, B., Gonzalez, E., Nieto Ortega, R., Andrade, M., Calderon, J., Chavez, C., Correa Flores, R.M., Farfan, J., Lu, L., Luque, E., Manrique, H., Mogrovejo, W., Pariona-Javier, M., Pinto, M., Roldan, Y., Zubiate, C., Dans, A., Gomez, M.H., Panelo, A., Rey, N., Sulit, D.J., Sy, R.A., Timonera, M., Bednarski, J., Bijata-Bronisz, R., Bryniarski, L., Busz-Papiez, B., Czajkowska-Kaczmarek, E., Drzewiecka, A., Dulak, E., Gorska, M., Hamankiewicz, M., Janik, K., Kincel, K., Konieczny, M., Lubinski, A., Olszanecka-Glinianowicz, M., Ponikowski, P., Pulka, G., Rekosz, J., Skudlarski, D., Szymkowiak, K., Wilczewski, P., Bragança, N., Duarte, J., Monteiro, P., Rodrigues, E., Vinhas, M., Adina, P.-M., Avram, R.I., Cif, A., Creteanu, G., Dragomir, D., Ferariu, I.E., Iancu, A.-C., Istratoaie, O., Ivanica, G., Lichiardopol, R., Militaru, C., Minescu, B., Onaca, A., Pintilei, E., Podoleanu, C., Pop, L., Popa, B., Ranetti, A.E., Rosu, D., Tase, A., Tesloianu, D.N., Vinereanu, D., Ageev, F., Akhmedzhanov, N., Barbarash, O., Barbarich, V., Belousov, Y., Berns, S., Bokarev, I., Bolshakova, O., Boyarkin, M., Chumakova, G., Dmitry, P., Fitilev, S., Galyavich, A., Glezer, M., Ivanova, L., Kalashnikov, V., Kalashnikova, M., Karpov, Y., Khaisheva, L., Khalimov, Y., Kobalava, Z., Kosmachova, E., Kostenko, V., Koziolova, N., Kulibaba, E., Lesnov, V., Libov, I., Lyamina, N., Markov, V., Moiseev, V., Molchanova, O., Oleynikov, V., Orlikova, O., Panov, A., Rafalskiy, V., Rodionova, T., Samitin, V., Schokotov, V., Shilkina, N., Shogenov, Z., Shustov, S., Shvarts, Y., Sobolev, K., Stryuk, R., Suplotova, L., Viktorova, I., Vishnevsky, A., Vorokhobina, N., Yakusevich, V., Yakushin, S., Zadionchenko, V., Zalevskaya, A., Zalevsky, G., Zateyshchikova, A., Andjelic Jelic, M., Kocic, R., Komnenovic, S., Lalic, K., Lalic, N., Micic, D., Otasevic, P., Pesic, M., Seferovic, P., Stankovic, G., Arnold, S., Burgess, L., Coetzee, K., Dawood, S., Delport, E., Ebrahim, I., Ellis, G., Ismail, S., Kelbe, D., Naidoo, V., Ntsekhe, M., Sebastian, P.J., Siebert, M., Van Zyl, L., Venter, T., Lonso, E., Antorrena, I., Bodi, V., Botella, M., De La Fuente, J., Delgado, E., Duran Garcia, S., Elorza, J., Enciso, F., Gaztambide, S., Marin, F., Martin, V., Mauricio, D., Soto, A., Vida, M., Boberg, G., Jörneskog, G., Jendle, J., Mathiesen, U., Svensson, K.-A., Torstensson, I., Vasko, P., Moccetti, T., Chiang, C.-E., Chiu, Y.-W., Huang, T.-Y., Lu, C.-H., Pei, D., Shyu, K.-G., Ueng, K.-C., Wang, T.-D., Abid, M., Ben Abdallah, N., Haouala, H., Slimane, H., Zidi, B., Bascil Tutuncu, N., Camsari, A., Delibasi, T., Dinccag, N., Kultursay, H., Oto, A., Sahin, M., Saygili, F., Yigit, Z., Zorkun, C., Karpenko, O., Korpachev, V., Koval, O., Maslyanko, V., Perepelytsya, M., Pertseva, T., Petrosyan, O., Rudenko, L., Sychov, O., Synenko, V., Tseluyko, V., Zhuravleva, L., Al Mahmeed, W., Kaddaha, G.M., Andrews, R., Bain, S., Basu, A., Bhatnagar, D., Bickerton, A., Browne, D., Gibson, M., Hammond, P., Hanna, F., Issa, B., Jaap, A., Joseph, F., Jude, E., Kelly, C., Khan, A., Malik, R., Mukhopadhyay, B., O'Kane, M., Rayman, G., Robinson, A., Rooney, D., Sainsbury, C., Saravanan, P., Shakher, J., Singh, B., Turner, J., Whitelaw, D., Wilding, J., Wiles, P., Adenuga, B., Ahmad, Z., Akinboboye, O., Akright, L., Alappat, P., Alawad, M., Alfonso, T., Alimard, R., Alzohaili, O., Ariani, M., Arora, C., Azad, N., Azzam, S., Benjamin, S., Block, B., Borzadek, E., Breisblatt, W., Bright, T., Byrd, L., Chiou, C., Chochinov, R., Christensen, T., Christofides, E., Cohen, R., Dawood, G., De Souza, J., Dempsey, M., Eagerton, D., East, C., Elder, C., Fernando, R., Fogelfeld, L., Foucauld, J., French, W., Frohnauer, M., Gaffney, M., Gangopadhyay, S., Gogia, H., Gosmanov, A., Greenberg, C., Greenway, F., Hanna, E., Hargrove, J., Harris, A., Harris, B., Hart, T., Herrington, D., Hewitt, M., Howard, D., Izuora, K., Jetty, P., Kapoor, A., Kasper, J.F., Kelehan, S., Kelly, R., Kereiakes, D., Khaira, A., Khan, M., Khan, S., Korban, E., Kosiborod, M., Laguerre, J., Larocque, J., Latif, K., Lester, F., Levin, P., Levine, S., Li, C., Lovell, C., Lupovitch, S., Madu, I.-J., Mahabadi, V., Mahmood, A., Maragos, S., Mariash, C., Martin, P., Mathew, J., May, M., Mayfield, R., McCall, A., Mcdaniel, C., Mcgrew, F., Mckenzie, M., Mefford, I., Mehta, A., Mikdadi, G., Mikhail, M., Monchamp, T., Moore, C., Moran, M., Morrar, N., Mosley, J., Mulford, M., Murray, J., Nakhle, S., Nallasivan, M., Odio, A., Oh, C., Olelewe, S., Palchick, B., Paliwal, Y., Papademetriou, V., Parikh, N., Patel, S., Phillips, L., Pitts, T., Prieto, F., Puttnam, R., Quyyumi, A., Randhawa, P., Rendell, M., Rhie, F., Roberts, J., Robinson, J., Robinson, M., Rubino, J., Ryan, E., Saathoff, S., Sachmechi, I., Saifi, A., Salacata, A., Sanders, R., Sanson, J., Savin, V., Schabauer, A., Schmedtje, J., Schwartz, A., Scott, C., Selagamsetty, M., Shannon, M., Shaw, S., Singal, D., Sjoberg, R., Smith, K., Sofley, C., Sonn, A., Sorof, S., Soroka, E., Spellman, C.W., Steinhoff, J., Suresh, D., Tahir, M., Tanenberg, R., Thawani, H., Thomson, S., Thrasher, J., Trachtenbarg, D., Trotta, M., Tuan, W., Twahirwa, M., Umpierrez, G., Vaid, B., Vance, C., Wang, T., Warner, A., Watson, H., Weber, S., Webster, B., Weindorff, K., Welch, M., Welker, J., White, A., White, L., Williams, M., Wu, W.-C., Wynne, A., Yocono, M., Yuen, K., UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, Bentley-Lewis, R., Aguilar, D., Riddle, M.C., Claggett, B., Diaz, R., Dickstein, K., Gerstein, H.C., Johnston, P., Køber, L.V., Lawson, F., Lewis, E.F., Maggioni, A.P., McMurray, J.J.V., Ping, L., Probstfield, J.L., Solomon, S.D., Tardif, J.-C., Wu, Y., Pfeffer, M.A., Barkoudah, E., Brahimi, A., Charytan, D., Finn, P., Flynn, A., Hartley, L.H., Henderson, G., Joseph, J., Odutayo, K., Rajesh, V., Vazir, A., Weinrauch, L., Del Prato, S., Petrie, J., Kaplan, A., Lieberman, P., Zuraw, B.L., O'Reilly, E., Patel, K., Allen, P., Scarpa, A., Schattner, M., Granger, C., Rouleau, J., DeMets, D., Chaturvedi, N., Raccah, D., Aizenberg, D., Alvarez, C., Alvarisqueta, A., Baccaro, C., Bartolacci, I., Bordonava, A., Bustamante Labarta, M., Caccavo, A., Calella, P., Cantero, M., Codutti, R., Commendatore, V., Costamagna, O., Cuello, J., Fernandez, A., Garcia Duran, R., Gomez Vilamajo, O., Gorban De Lapertosa, S., Grinfeld, D., Hermida, S., Lagrutta, M., Leon De La Fuente, R., Licheri, A., Luciardi, H., Mackinnon, I., Maffei, L., Marino, J., Montaña, O., Novaretto, L., Orio, S., Orlandini, A., Oviedo, A., Pérez Manghi, F., Patocchi, C., Ramos, H., Rolandi, F., Saa Zarandon, R., Saavedra, S.S., Schiavi, L., Schygiel, P., Trivi, M., Ulla, M., Urdiales, P., Vallejos, J., Vico, M., Waisman, F., Amerena, J., Paul, V., Sangla, K., Van Gaal, W., Yeap, B., Fasching, P., Pieber, T., Danilova, L., Mitkovskaya, N., Sudzhaeva, S., Mathieu, C., Pouleur, Anne-Catherine, Botelho, R.V., Cerqueira, M.J., Chacra, A., Dos Santos, F., Feitosa, G., Forti, A., Golbert, M., Halpern, A., Hissa, M., Lisboa, H., Moraes, J., Nery, M., Quadros, A., Raduan, R., Reis, G., Ribeiro Filho, F., Rollin, G., Rossi, P., Santos, E., Sgarbi, J., Souza, J., Souza, M.R., Delchev, A., Ivanov, V., Klyuchkova, N., Kyoleyan, M., Levterov, G., Lucheva, M., Raev, D., Shumkova, R., Tokmakova, M., Tzekova, M., Yordanov, V., Bailey, G., Bertrand, O., Bhargava, R., Burton, J., Campeau, J., Dumas, R., Filteau, P., Syan, G., Syan, R., Tsoukas, G., Warnica, J.W., Acuña, S., Araneda, G., Bunster, L., Cobos, L., Corbalán, R., Dussaillant, G., Eggers, G., Florenzano, F., Godoy, G., Huidobro, L.A., Lahsen, R., Lanas, F., Larenas, G., Manriquez, L., Medina, M., Palma, J.C., Perez, L., Potthoff, S., Raffo, C., Reyes, E., Saavedra, V., Sanhueza, P., Sepulveda, P., Solis, C.L., Soto, N., Torres, C., Westerberg, B., Yañez, M., Chen, L., Dong, Y., Du, J., Guo, X., Han, P., Hu, T., Jiang, B., Ke, Y., Li, Z., Lu, J., Ma, C., Peng, Y., Shi, Y., Su, G., Tang, B., Xu, B., Yang, J., Yang, Y., Accini, J.L., Arteaga, J.M., Botero, R., Castillo, G., Coronel, J., Cure, C., Garcia, H., Garcia, L., Gomez, C., Hernandez Triana, E., Hernandez, H., Lopez, M., Lopez, P., Manzur, F., Molina, D., Rodriguez, J., Sanchez Vallejo, G., Yupanqui, H., Bronnum-Schou, J., Kaiser Nielsen, P., Nielsen, H., Rønne, H., Rasmussen, S., Rungby, J., Skagen, K., Thomsen, K.K., Torp-Pedersen, C., Duarte-Vera, Y., Marmol Alvear, R., Peñaherrera-Patiño, C., Assaad, S., Shelbaya, S., Ambos, A., Jakovlev, U., Lubi, M., Märtsin, K., Rosenthal, S., Vides, H., Alanko, J., Korsoff, P., Koski, A.-M., Lahtela, J., Nelimarkka, L., Tuomilehto, J., Cariou, B., Catargi, B., Ducloux, R., Hadjadj, S., Kerlan, V., Malecot, J.-M., Petit, C., Rodier, M., Chumburidze, V., Glonti, S., Lominadze, Z., Todua, F., Contzen, C., Marck, C., Fischer, H., Hagenow, A., Himpel-Bönninghoff, A., Kihm, L., Killat, H., Kleinertz, K., Kosch, C., Kreutzmann, K., Lappo, M., Mertes, B., Piechatzek, R., Prohaska, M., Rinke, A., Schellenberg, D., Toursarkissian, N., Arango, J., Gonzalez, R., Granados, A., Herrera, M., Montenegro, P., Munoz, R., Rodriguez, E., Turcios, E., Villalobos, R., Wyss, F., Hatterjee, S., Chopda, M., Chopra, V., Deshpande, N., Dutta, R., Dwivedi, S., Gandhi, P., Gupta, S.K., Gupta, J.B., Gupta, S., Hiregouder, N., Jha, S., Joshi, A., Khan, N., Kumbla, M., Magdum, M., Murthy, K., Prabhu, M., Sahay, R., Sethuraman, S., Shah, N., Shamanna, P., Singh, K.S., Singh, P., Somasekharan, A., Sreenivasamurthy, L., Supe, P., Adawi, F., Atar, S., Cohen, O., Efrati, S., Karnieli, E., Klainman, E., Minuchin, O., Mosenzon, O., Stern, N., Turgeman, Y., Wainstein, J., Aimaretti, G., Berra, C., Ciardullo, A.V., Consoli, A., Cucinotta, D., Di Marco, S., Giorda, C., Giordano, C., Mannucci, E., Orsi, E., Piatti, P., Pontiroli, A., Ponzani, P., Pozzilli, P., Rivellese, A., Akahori, H., Eki, Y., Fujii, K., Hata, Y., Himeno, H., Hirayama, A., Kishimoto, I., Kobayashi, Y., Miyaoka, H., Niiya, T., Nishi, Y., Nozaki, A., Nunohiro, T., Saito, T., Satoh, Y., Takahashi, A., Takahashi, J., Takase, H., Takase, S., Tsuboko, Y., Tsujimoto, M., Tsujino, M., Tsuzuki, M., Watanabe, S., Yamada, T., Chung, W.J., Rim, S., Jang, H., Kim, U., Chung, C.H., Shin, S.-H., Kim, K., Kim, J., Rha, S., Lee, N.H., Kim, C.-J., Park, K.S., Amolina, I., Ducena, K., Helda, R., Konrade, I., Pirags, V., Sime, I., Sokolova, J., Kakariekiene, V., Kavaliauskiene, R., Petrulioniene, Z., Sakalyte, G., Urboniene, A., Zarankiene, R., Uribe, M., Garcia-Hernandez, P., Garza, J., Vazquez-Garcia, A., Gonzalez, J.G., Escalante, M., Zavala, A., Bayram, E., Hernandez-Muñuzuri, J., Ramos, Lopez, G.A., Lujan, J., Garcia-Soria, M., Velasco-Sanchez, R., Rodriguez, I., Jimenez, S., Galeana, C., Lara, S., Garcia-Castillo, A., Castro, M.G., Aguilar-Orozco, R., Lopez Rosas, E., Vidrio, M., Llamas, G., Stobschinski De Alba, C.A., Carranza-Madrigal, J., Cardosa-Torres, F., Cornel, J.H., Dekkers, P., Frederiks, J., Hermans, W., Lok, D., Meeder, J., Nierop, P., Cooper, J., Lappegård, K.T., Nedrebø, B.G., Castro, E., Gonzalez Castillo, B., Gonzalez, E., Nieto Ortega, R., Andrade, M., Calderon, J., Chavez, C., Correa Flores, R.M., Farfan, J., Lu, L., Luque, E., Manrique, H., Mogrovejo, W., Pariona-Javier, M., Pinto, M., Roldan, Y., Zubiate, C., Dans, A., Gomez, 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S., Webster, B., Weindorff, K., Welch, M., Welker, J., White, A., White, L., Williams, M., Wu, W.-C., Wynne, A., Yocono, M., and Yuen, K.

Abstract

Background: Cardiovascular (CV) disease is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Furthermore, patients with T2DM and acute coronary syndrome (ACS) have a particularly high risk of CV events. The glucagonlike peptide 1 receptor agonist, lixisenatide, improves glycemia, but its effects on CV events have not been thoroughly evaluated. Methods: ELIXA (www.clinicaltrials.gov no. NCT01147250) is a randomized, double-blind, placebo-controlled, parallelgroup, multicenter study of lixisenatide in patients with T2DM and a recent ACS event. The primary aim is to evaluate the effects of lixisenatide on CV morbidity and mortality in a population at high CV risk. The primary efficacy end point is a composite of time to CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. Data are systematically collected for safety outcomes, including hypoglycemia, pancreatitis, and malignancy. Results: Enrollment began in July 2010 and ended in August 2013; 6,068 patients from 49 countries were randomized. Of these, 69% are men and 75% are white; at baseline, the mean ± SD age was 60.3 ± 9.7 years, body mass index was 30.2 ± 5.7 kg/m2, and duration of T2DM was 9.3±8.2 years. The qualifying ACS wasamyocardial infarctionin83% and unstableangina in 17%. The study will continue until the positive adjudication of the protocol-specified number of primary CV events. Conclusion: ELIXA will be the first trial to report the safety and efficacy of a glucagon-like peptide 1 receptor agonist in people with T2DM and high CV event risk. © 2015 Elsevier Inc. All rights reserved.

Published
2015

30. Community acquired bacteraemia in the elderly

Author

Whitelaw, D A, Willcox, Paul, Whitelaw, D A, Whitelaw, D A, Willcox, Paul, and Whitelaw, D A

Abstract

Age affects the human frame at all levels - from the skin which is ravaged by exposure to ultraviolet light and toxic irritants to the immune system which becomes progressively less responsive to antigenic stimuli. Bacteraemia follows a focal infection and thus any change which results in increased infection will result in an increased chance of bacteraemia. Therefore any factors bearing on focal infection will, of necessity influence not only the possibility but also the severity of a bacteraemia.

Published
1990

32. In vitro susceptibilities in lymphocytes from mothers and cord blood to the monofunctional alkylating agent EMS

Author

Wyatt, N P, Falque-Gonzalez, C, Farrar, D, Tuffnell, D, Whitelaw, D, Knudsen, Lisbeth E., Anderson, D, Wyatt, N P, Falque-Gonzalez, C, Farrar, D, Tuffnell, D, Whitelaw, D, Knudsen, Lisbeth E., and Anderson, D

Abstract

Udgivelsesdato: 2007-Mar, It has been reported that children may experience different levels of chemical exposures than adults and that their sensitivities to chemical toxins may be increased or decreased when compared to adults. The perinatal period is one period in which these susceptibilities may be examined. Midwives at the Bradford Royal Infirmary collected venous blood samples from mothers at the time of birth and venous cord blood post-delivery. Lymphocytes were isolated from both blood types and examined in the alkaline comet assay using the monofunctional alkylating agent ethyl methanesulphonate (EMS). There were no biologically significant differences when subjects were categorized into subgroups based on lifestyle habits and physical characteristics, and overall there were no statistically significant differences in levels of DNA damage in mothers (n=22) and babies (n=22), except at the basal level (P<0.05), but mean values in babies were always lower over the EMS dose range. Whole blood was used in the micronucleus (MN) assay, and there was a significantly (P<0.05) higher rate of MN in mothers (n=17), per 1000 binucleates, as compared with lymphocytes from their offspring (n=17) at the basal level. This may be accounted for by age and endogenous factors. Overall, this current study cannot provide statistically significant evidence that children have either increased or decreased levels of susceptibility to a chemical toxin in comparison to adults when EMS is examined in vitro.

Published
2007

45. SHORT NOTES

Author

Ryan, Peter G., primary, Hockey, Philip A.R., additional, Berruti, A., additional, McIntosh, B., additional, Walter, R., additional, Whitelaw, D. A., additional, and Thompson, H. S.S., additional

Published
1995
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47. An investigation in the possible effect of chronic headache on neuropsychological function in aCL-negative patients with SLE.

Author

Whitelaw, D. A. and Spangenberg, J. J.

Subjects
*MIGRAINE, *SYSTEMIC lupus erythematosus, *AUTOIMMUNE diseases, *MAGNETIC resonance imaging, *HEADACHE, *PATIENTS
Abstract

Controversy exists as to whether patients with migraine may suffer cortical damage. We investigate the possible association between impaired cognitive function and chronic headache in lupus patients. Sixty one patients with systemic lupus erythematosus but without the antiphospholipid (Hughes) syndrome were questioned about headaches and formally assessed for cognitive function. They were also subjected to magnetic resonance imaging (MRI). Twenty one patients denied any significant headaches, 19 reported migrainous headaches and 11 experienced an aura. Eleven patients experienced headaches with features of migraine but did not fulfill the criteria, and seven patients had tension headaches. All patients had stable lupus; there was no difference in the incidence of hypertension, age or previous episodes of neuropsychiatric lupus. Patients with migrainous headaches without aura had marginally shorter duration of disease. There was no difference between the groups with respect to eight different cognitive tests or the ventriculo brain index on MRI. We failed to detect cognitive impairment in lupus patients with chronic headaches including migrainous headaches. [ABSTRACT FROM AUTHOR]

Published
2009
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49. Risk factors for coronary heart disease in obese non-diabetic subjects.

Author

Whitelaw, D C, O'Kane, M, Wales, J K, and Barth, J H

Subjects
*BODY weight, *CORONARY disease, *OBESITY
Abstract

OBJECTIVE: To examine relationships between body mass index (BMI) and coronary risk factors in obese subjects presenting to a dedicated obesity clinic. STUDY DESIGN: Cross-sectional population survey from a single centre. SUBJECTS: Three hundred and eighty-six consecutive non-diabetic obese subjects (301 women, 85 men) attending an obesity clinic for the first time (mean BMI 43.3 kg/m²; range 30.6-71.5), aged 17-69 y (mean 40.1). MEASUREMENTS: Height, weight, resting blood pressure, fasting plasma cholesterol, triglyceride, glucose and uric acid concentrations. RESULTS: All variables measured showed an increase with higher BMI (triglycerides, P=0.04; glucose, P=0.007; urate, P<0.001; systolic BP, P<0.001; diastolic BP, P<0.001) as measured by one-way ANOVA, except cholesterol concentration which showed no relationship with BMI. In comparison with the group of subjects with BMI 30-35 kg/m² mean values for all variables were higher in the more obese subjects. CONCLUSIONS: Non-diabetic subjects with BMI>35 kg/m² carry a burden of common coronary risk factors which appears to increase with greater obesity. The risk factor pattern observed echoes that described in insulin resistance syndromes. Plasma cholesterol concentration appears not to be related to BMI. [ABSTRACT FROM AUTHOR]

Published
2001
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