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17 results on '"White, Sharon J."'

4. Localised oral amyloidosis in the context of oral epithelial dysplasia: Literature review and report of two cases.

Author

Dobson, Marianne L., Wright, Alison L., White, Sharon J., and Macluskey, Michaelina

Subjects
CARDIAC amyloidosis, AMYLOIDOSIS, IMMUNOGLOBULIN light chains, DYSPLASIA, LITERATURE reviews, AMYLOID plaque
Abstract

Amyloidosis is a group of rare progressive diseases that occur as a result of abnormal protein folding and aggregation. Systemic amyloidosis is a serious disease with high mortality, and prompt diagnosis is key to improving prognosis. Conversely, localised amyloidosis does not reduce life expectancy and can often be treated with simple surgical excision. Amyloid deposits can be found in the oral cavity, usually in the context of systemic amyloidosis. We present two cases of localised oral acquired immunoglobulin light chain (AL) amyloidosis that were detected in oral biopsies taken for the management of oral epithelial dysplasia (OED). Both patients underwent thorough multisystem investigations by haematology in conjunction with the NHS National Amyloidosis Centre (NAC) in order to exclude systemic amyloidosis and confirm the diagnosis. Localised oral amyloidosis is rare, and to our knowledge, localised oral AL amyloidosis has not been reported in the context of OED before. We discuss important learning points from these cases as well as hypothesising on the pathophysiology involved. [ABSTRACT FROM AUTHOR]

Published
2022
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7. Late Simultaneous Metastasis of Renal Cell Carcinoma to the Submandibular and Thyroid Glands Seven Years after Radical Nephrectomy

Author

Miah, Mohammed S., White, Sharon J., Oommen, George, Birney, Esther, and Majumdar, Samit

Subjects
stomatognathic system, Article Subject, urologic and male genital diseases
Abstract

Background. Renal cell carcinoma (RCC) metastasis to the salivary glands is extremely rare. Most cases reported previously have involved the parotid gland and only six cases involving the submandibular gland exist in the current literature. Metastasis of RCC to thyroid gland is also rare but appears to be more common than to salivary glands. Methods and Results. We present the first case of simultaneous metastasis to the submandibular and thyroid glands from clear cell RCC in a 61-year-old woman who presented seven years after the primary treatment. The submandibular and thyroid glands were excised completely with preservation of the marginal mandibular and recurrent laryngeal nerves, respectively. Conclusion. Metastatic disease should always be considered in the differential diagnosis for patients who present with painless salivary or thyroid gland swelling with a previous history of RCC. If metastatic disease is confined only to these glands, prompt surgical excision can be curative.

Published
2010
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12. Primary Cutaneous CD8-Positive T-Cell Lymphoma: A Case Report of a Rare and Aggressive Disease with Oral Presentation.

Author

Geddes, Alan, Savin, Julie, White, Sharon J., and Gibson, John

Subjects
T-cell lymphoma, ORAL medicine, MOUTH ulcers, PRACTICE of dentistry
Abstract

A case of a 66-year-old man, who was referred to the Oral Medicine service with persistent oral ulceration and widespread cutaneous rash is presented. Laboratory investigations confirmed a diagnosis of epitheliotropic, CD8-positive, cytotoxic, 1-cell lymphoma. Clinical Relevance: Oral ulceration represents a heterogeneous group of aetiologies: the patient with this more concerning pathology presented both to his general medical and dental practitioners. [ABSTRACT FROM AUTHOR]

Published
2011
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13. Calibre-Persistent Artery of the Nose.

Author

Miah, Mohammed S., White, Sharon J., and Mahendran, Suresh

Subjects
*NOSEBLEED, *BLOOD-vessel abnormalities, *NOSE, *HISTOPATHOLOGY, *HEMORRHAGE treatment, *CAUTERY, *LOCAL anesthesia
Abstract

A case study is presented of a 55-year-old patient who presented with a nasal calibre-persistent artery. It states she had a history of progressive recurrent epistaxis from a nonpulsatile lesion on the left nasal vestibule which would bleed profusely on occasion, usually after she removed a scab from the lesion. It mentions the lesion was removed under local anesthesia with a histopathological examination determining its nature while bipolar cautery was used to control interoperative bleeding.

Published
2010
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14. POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in head and neck cancer

Author

Sharpe, Daniel J., Orr, Katy S., Moran, Michael, White, Sharon J., McQuaid, Stephen, Lappin, Terence R., Thompson, Alexander, James, Jacqueline A., Sharpe, Daniel J., Orr, Katy S., Moran, Michael, White, Sharon J., McQuaid, Stephen, Lappin, Terence R., Thompson, Alexander, and James, Jacqueline A.

Abstract

HOX genes are master regulators of organ morphogenesis and cell differentiation during embryonic development, and continue to be expressed throughout post-natal life. To test the hypothesis that HOX genes are dysregulated in head and neck squamous cell carcinoma (HNSCC) we defined their expression profile, and investigated the function, transcriptional regulation and clinical relevance of a subset of highly expressed HOXD genes. Two HOXD genes, D10 and D11, showed strikingly high levels in HNSCC cell lines, patient tumor samples and publicly available datasets. Knockdown of HOXD10 in HNSCC cells caused decreased proliferation and invasion, whereas knockdown of HOXD11 reduced only invasion. POU2F1 consensus sequences were identified in the 5’ DNA of HOXD10 and D11. Knockdown of POU2F1 significantly reduced expression of HOXD10 and D11 and inhibited HNSCC proliferation. Luciferase reporter constructs of the HOXD10 and D11 promoters confirmed that POU2F1 consensus binding sites are required for optimal promoter activity. Utilizing patient tumor samples a significant association was found between immunohistochemical staining of HOXD10 and both the overall and the disease-specific survival, adding further support that HOXD10 is dysregulated in head and neck cancer. Additional studies are now warranted to fully evaluate HOXD10 as a prognostic tool in head and neck cancers.

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15. POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in head and neck cancer

Author

Sharpe, Daniel J., Orr, Katy S., Moran, Michael, White, Sharon J., McQuaid, Stephen, Lappin, Terence R., Thompson, Alexander, James, Jacqueline A., Sharpe, Daniel J., Orr, Katy S., Moran, Michael, White, Sharon J., McQuaid, Stephen, Lappin, Terence R., Thompson, Alexander, and James, Jacqueline A.

Abstract

HOX genes are master regulators of organ morphogenesis and cell differentiation during embryonic development, and continue to be expressed throughout post-natal life. To test the hypothesis that HOX genes are dysregulated in head and neck squamous cell carcinoma (HNSCC) we defined their expression profile, and investigated the function, transcriptional regulation and clinical relevance of a subset of highly expressed HOXD genes. Two HOXD genes, D10 and D11, showed strikingly high levels in HNSCC cell lines, patient tumor samples and publicly available datasets. Knockdown of HOXD10 in HNSCC cells caused decreased proliferation and invasion, whereas knockdown of HOXD11 reduced only invasion. POU2F1 consensus sequences were identified in the 5’ DNA of HOXD10 and D11. Knockdown of POU2F1 significantly reduced expression of HOXD10 and D11 and inhibited HNSCC proliferation. Luciferase reporter constructs of the HOXD10 and D11 promoters confirmed that POU2F1 consensus binding sites are required for optimal promoter activity. Utilizing patient tumor samples a significant association was found between immunohistochemical staining of HOXD10 and both the overall and the disease-specific survival, adding further support that HOXD10 is dysregulated in head and neck cancer. Additional studies are now warranted to fully evaluate HOXD10 as a prognostic tool in head and neck cancers.

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16. POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in head and neck cancer

Author

Sharpe, Daniel J., Orr, Katy S., Moran, Michael, White, Sharon J., McQuaid, Stephen, Lappin, Terence R., Thompson, Alexander, James, Jacqueline A., Sharpe, Daniel J., Orr, Katy S., Moran, Michael, White, Sharon J., McQuaid, Stephen, Lappin, Terence R., Thompson, Alexander, and James, Jacqueline A.

Abstract

HOX genes are master regulators of organ morphogenesis and cell differentiation during embryonic development, and continue to be expressed throughout post-natal life. To test the hypothesis that HOX genes are dysregulated in head and neck squamous cell carcinoma (HNSCC) we defined their expression profile, and investigated the function, transcriptional regulation and clinical relevance of a subset of highly expressed HOXD genes. Two HOXD genes, D10 and D11, showed strikingly high levels in HNSCC cell lines, patient tumor samples and publicly available datasets. Knockdown of HOXD10 in HNSCC cells caused decreased proliferation and invasion, whereas knockdown of HOXD11 reduced only invasion. POU2F1 consensus sequences were identified in the 5’ DNA of HOXD10 and D11. Knockdown of POU2F1 significantly reduced expression of HOXD10 and D11 and inhibited HNSCC proliferation. Luciferase reporter constructs of the HOXD10 and D11 promoters confirmed that POU2F1 consensus binding sites are required for optimal promoter activity. Utilizing patient tumor samples a significant association was found between immunohistochemical staining of HOXD10 and both the overall and the disease-specific survival, adding further support that HOXD10 is dysregulated in head and neck cancer. Additional studies are now warranted to fully evaluate HOXD10 as a prognostic tool in head and neck cancers.

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17. POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in head and neck cancer

Author

Sharpe, Daniel J., Orr, Katy S., Moran, Michael, White, Sharon J., McQuaid, Stephen, Lappin, Terence R., Thompson, Alexander, James, Jacqueline A., Sharpe, Daniel J., Orr, Katy S., Moran, Michael, White, Sharon J., McQuaid, Stephen, Lappin, Terence R., Thompson, Alexander, and James, Jacqueline A.

Abstract

HOX genes are master regulators of organ morphogenesis and cell differentiation during embryonic development, and continue to be expressed throughout post-natal life. To test the hypothesis that HOX genes are dysregulated in head and neck squamous cell carcinoma (HNSCC) we defined their expression profile, and investigated the function, transcriptional regulation and clinical relevance of a subset of highly expressed HOXD genes. Two HOXD genes, D10 and D11, showed strikingly high levels in HNSCC cell lines, patient tumor samples and publicly available datasets. Knockdown of HOXD10 in HNSCC cells caused decreased proliferation and invasion, whereas knockdown of HOXD11 reduced only invasion. POU2F1 consensus sequences were identified in the 5’ DNA of HOXD10 and D11. Knockdown of POU2F1 significantly reduced expression of HOXD10 and D11 and inhibited HNSCC proliferation. Luciferase reporter constructs of the HOXD10 and D11 promoters confirmed that POU2F1 consensus binding sites are required for optimal promoter activity. Utilizing patient tumor samples a significant association was found between immunohistochemical staining of HOXD10 and both the overall and the disease-specific survival, adding further support that HOXD10 is dysregulated in head and neck cancer. Additional studies are now warranted to fully evaluate HOXD10 as a prognostic tool in head and neck cancers.

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