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2. Automatic rating of incomplete hippocampal inversions evaluated across multiple cohorts

Author

Hemforth, Lisa, Couvy-Duchesne, Baptiste, De Matos, Kevin, Brianceau, Camille, Joulot, Matthieu, Banaschewski, Tobias, Bokde, Arun L. W., Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Brühl, Rüdiger, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Artiges, Eric, Papadopoulos, Dimitri, Lemaitre, Herve, Paus, Tomas, Poustka, Luise, Hohmann, Sarah, Holz, Nathalie, Fröhner, Juliane H., Smolka, Michael N., Vaidya, Nilakshi, Walter, Henrik, Whelan, Robert, Schumann, Gunter, Büchel, Christian, Poline, JB, Itterman, Bernd, Frouin, Vincent, Martin, Alexandre, group, IMAGEN study, Cury, Claire, and Colliot, Olivier

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning, Quantitative Biology - Neurons and Cognition
Abstract

Incomplete Hippocampal Inversion (IHI), sometimes called hippocampal malrotation, is an atypical anatomical pattern of the hippocampus found in about 20% of the general population. IHI can be visually assessed on coronal slices of T1 weighted MR images, using a composite score that combines four anatomical criteria. IHI has been associated with several brain disorders (epilepsy, schizophrenia). However, these studies were based on small samples. Furthermore, the factors (genetic or environmental) that contribute to the genesis of IHI are largely unknown. Large-scale studies are thus needed to further understand IHI and their potential relationships to neurological and psychiatric disorders. However, visual evaluation is long and tedious, justifying the need for an automatic method. In this paper, we propose, for the first time, to automatically rate IHI. We proceed by predicting four anatomical criteria, which are then summed up to form the IHI score, providing the advantage of an interpretable score. We provided an extensive experimental investigation of different machine learning methods and training strategies. We performed automatic rating using a variety of deep learning models (conv5-FC3, ResNet and SECNN) as well as a ridge regression. We studied the generalization of our models using different cohorts and performed multi-cohort learning. We relied on a large population of 2,008 participants from the IMAGEN study, 993 and 403 participants from the QTIM/QTAB studies as well as 985 subjects from the UKBiobank. We showed that deep learning models outperformed a ridge regression. We demonstrated that the performances of the conv5-FC3 network were at least as good as more complex networks while maintaining a low complexity and computation time. We showed that training on a single cohort may lack in variability while training on several cohorts improves generalization., Comment: Accepted for publication at the Journal of Machine Learning for Biomedical Imaging (MELBA) https://melba-journal.org/2024:016

Published
2024
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5. Light Cannabis Use and the Adolescent Brain: An 8-years Longitudinal Assessment of Mental Health, Cognition, and Reward Processing

Author

Macedo, Inês, Paiva, Tiago O., Pasion, Rita, Daedelow, Laura, Heinz, Andreas, Magalhães, Ana, Banaschewski, Tobias, Bokde, Arun L. W., Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Brühl, Rüdiger, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Artiges, Eric, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Holz, Nathalie, Fröhner, Juliane H., Smolka, Michael N., Vaidya, Nilakshi, Walter, Henrik, Whelan, Robert, Schumann, Gunter, and Barbosa, Fernando

Published
2024
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7. Regional patterns of human cortex development correlate with underlying neurobiology

Author

Lotter, Leon D., Saberi, Amin, Hansen, Justine Y., Misic, Bratislav, Paquola, Casey, Barker, Gareth J., Bokde, Arun L. W., Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Brühl, Rüdiger, Martinot, Jean-Luc, Paillère, Marie-Laure, Artiges, Eric, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Fröhner, Juliane H., Smolka, Michael N., Vaidya, Nilakshi, Walter, Henrik, Whelan, Robert, Schumann, Gunter, Nees, Frauke, Banaschewski, Tobias, Eickhoff, Simon B., and Dukart, Juergen

Published
2024
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8. Investigating grey matter volumetric trajectories through the lifespan at the individual level

Author

Shi, Runye, Xiang, Shitong, Jia, Tianye, Robbins, Trevor W., Kang, Jujiao, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Brühl, Rüdiger, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Artiges, Eric, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Millenet, Sabina, Fröhner, Juliane H., Smolka, Michael N., Vaidya, Nilakshi, Walter, Henrik, Whelan, Robert, Schumann, Gunter, Lin, Xiaolei, Sahakian, Barbara J., and Feng, Jianfeng

Published
2024
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9. The genetic architecture of the human hypothalamus and its involvement in neuropsychiatric behaviours and disorders

Author

Chen, Shi-Dong, You, Jia, Zhang, Wei, Wu, Bang-Sheng, Ge, Yi-Jun, Xiang, Shi-Tong, Du, Jing, Kuo, Kevin, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Brühl, Rüdiger, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Artiges, Eric, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Lemaitre, Herve, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Millenet, Sabina, Baeuchl, Christian, Smolka, Michael N., Vaidya, Nilakshi, Walter, Henrik, Whelan, Robert, Schumann, Gunter, Feng, Jian-Feng, Dong, Qiang, Cheng, Wei, and Yu, Jin-Tai

Published
2024
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10. Whole-brain gray matter maturation trajectories associated with autistic traits from adolescence to early adulthood

Author

Gros, Guillaume, Miranda Marcos, Ruben, Latrille, Anthony, Saitovitch, Ana, Gollier-Briant, Fanny, Fossati, Philippe, Schmidt, Liane, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Desrivières, Sylvane, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Brühl, Rüdiger, Martinot, Jean-Luc, Paillère Martinot, Marie-Laure, Artiges, Eric, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Poustka, Luise, Hohmann, Sarah, Holz, Nathalie, Fröhner, Juliane H., Smolka, Michael N., Vaidya, Nilakshi, Walter, Henrik, Whelan, Robert, Schumann, Gunter, Lemaitre, Hervé, and Vulser, Hélène

Published
2024
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11. Differential associations of adolescent versus young adult cannabis initiation with longitudinal brain change and behavior

Author

Albaugh, Matthew D., Owens, Max M., Juliano, Anthony, Ottino-Gonzalez, Jonatan, Cupertino, Renata, Cao, Zhipeng, Mackey, Scott, Lepage, Claude, Rioux, Pierre, Evans, Alan, Banaschewski, Tobias, Bokde, Arun L. W., Conrod, Patricia, Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Artiges, Eric, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Millenet, Sabina, Fröhner, Juliane H., Smolka, Michael N., Walter, Henrik, Whelan, Robert, Schumann, Gunter, Potter, Alexandra, and Garavan, Hugh

Published
2023
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13. Assessing general versus specific liability for externalizing problems in adolescence: Concurrent and prospective prediction of symptoms of conduct disorder, ADHD, and substance use.

Author

Perkins, Emily, Foell, Jens, Drislane, Laura, Brislin, Sarah, Frick, Paul, Yancey, James, Soto, Elia, Ganley, Colleen, Keel, Pamela, Sica, Claudio, Flor, Herta, Nees, Frauke, Banaschewski, Tobias, Bokde, Arun, Desrivières, Sylvane, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Paillère Martinot, Marie-Laure, Artiges, Eric, Papadopoulos Orfanos, Dimitri, Poustka, Luise, Hohmann, Sarah, Fröhner, Juliane, Smolka, Michael, Walter, Henrik, Whelan, Robert, Schumann, Gunter, Patrick, Christopher, and Joyner, Keanan

Subjects
Adolescent, Alcoholism, Attention Deficit Disorder with Hyperactivity, Conduct Disorder, Female, Humans, Male, Prospective Studies, Substance-Related Disorders
Abstract

This study explored the generality versus specificity of two trait-liability factors for externalizing problems-disinhibition and callousness-in the concurrent and prospective prediction of symptoms of conduct disorder, attention-deficit/hyperactivity disorder (ADHD), and substance use (i.e., alcohol use disorder and history of illicit substance use). Disinhibition involves an impulsive, unrestrained cognitive-behavioral style; callousness entails a dispositional lack of social-emotional sensitivity. Participants were European adolescents from the multisite IMAGEN project who completed questionnaires and clinical interviews at ages 14 (N = 1,504, Mage = 14.41, 51.13% female) and 16 (N = 1,407, Mage = 16.46, 51.88% female). Disinhibition was related concurrently and prospectively to greater symptoms of conduct disorder, ADHD, and alcohol use disorder; higher scores on a general externalizing factor; and greater likelihood of having tried an illicit substance. Callousness was selectively related to greater conduct disorder symptoms. These findings indicate disinhibition confers broad liability for externalizing spectrum disorders, perhaps due to its affiliated deficits in executive function. In contrast, callousness appears to represent more specific liability for antagonistic (aggressive/exploitative) forms of externalizing, as exemplified by antisocial behavior. Results support the utility of developmental-ontogenetic and hierarchical-dimensional models of psychopathology and have important implications for early assessment of risk for externalizing problems. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Published
2022

14. Distinct personality profiles associated with disease risk and diagnostic status in eating disorders

Author

Zhang, Zuo, Robinson, Lauren, Campbell, Iain, Irish, Madeleine, Bobou, Marina, Winterer, Jeanne, Zhang, Yuning, King, Sinead, Vaidya, Nilakshi, Broulidakis, M. John, van Noort, Betteke Maria, Stringaris, Argyris, Banaschewski, Tobias, Bokde, Arun L.W., Brühl, Rüdiger, Fröhner, Juliane H., Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Hohmann, Sarah, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Sinclair, Julia, Smolka, Michael N., Walter, Henrik, Whelan, Robert, Schumann, Gunter, Schmidt, Ulrike, and Desrivières, Sylvane

Published
2024
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15. Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits

Author

Xue, Kaizhong, Gao, Bo, Chen, Feng, Wang, Meiyun, Cheng, Jingliang, Zhang, Bing, Zhu, Wenzhen, Qiu, Shijun, Geng, Zuojun, Zhang, Xiaochu, Cui, Guangbin, Yu, Yongqiang, Zhang, Quan, Liao, Weihua, Zhang, Hui, Xu, Xiaojun, Han, Tong, Qin, Wen, Liu, Feng, Liang, Meng, Guo, Lining, Xu, Qiang, Xu, Jiayuan, Fu, Jilian, Zhang, Peng, Li, Wei, Shi, Dapeng, Wang, Caihong, Lui, Su, Yan, Zhihan, Zhang, Jing, Li, Jiance, Wang, Dawei, Xian, Junfang, Xu, Kai, Zuo, Xi-Nian, Zhang, Longjiang, Ye, Zhaoxiang, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Brühl, Rüdiger, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Artiges, Eric, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Lemaitre, Herve, Poustka, Luise, Hohmann, Sarah, Holz, Nathalie, Fröhner, Juliane H., Smolka, Michael N., Vaidya, Nilakshi, Walter, Henrik, Whelan, Robert, Shen, Wen, Miao, Yanwei, and Yu, Chunshui

Published
2023
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16. A stable and replicable neural signature of lifespan adversity in the adult brain

Author

Holz, Nathalie E., Zabihi, Mariam, Kia, Seyed Mostafa, Monninger, Maximillian, Aggensteiner, Pascal-M., Siehl, Sebastian, Floris, Dorothea L., Bokde, Arun L. W., Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Brühl, Rüdiger, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Fröhner, Juliane H., Smolka, Michael N., Vaidya, Nilakshi, Walter, Henrik, Whelan, Robert, Schumann, Gunter, Meyer-Lindenberg, Andreas, Brandeis, Daniel, Buitelaar, Jan K., Nees, Frauke, Beckmann, Christian, Banaschewski, Tobias, and Marquand, Andre F.

Published
2023
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17. Autistic traits and alcohol use in adolescents within the general population

Author

Pijnenburg, Lisa J., Kaplun, Anais, de Haan, Lieuwe, Janecka, Magdalena, Smith, Lauren, Reichenberg, Abraham, Banaschewski, Tobias, Bokde, Arun L. W., Quinlan, Erin Burke, Desrivières, Sylvane, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Millenet, Sabina, Fröhner, Juliane H., Smolka, Michael N., Walter, Henrik, Whelan, Robert, Schumann, Gunter, and Velthorst, Eva

Published
2023
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18. Multi-feature computational framework for combined signatures of dementia in underrepresented settings.

Author

Moguilner, Sebastian, Birba, Agustina, Fittipaldi, Sol, Gonzalez-Campo, Cecilia, Tagliazucchi, Enzo, Reyes, Pablo, Matallana, Diana, Parra, Mario, Slachevsky, Andrea, Farías, Gonzalo, Cruzat, Josefina, García, Adolfo, Eyre, Harris, La Joie, Renaud, Rabinovici, Gil, Whelan, Robert, and Ibáñez, Agustín

Subjects
feature selection, harmonization, machine learning, multimodal neuroimaging, neurodegeneration, Alzheimer Disease, Bayes Theorem, Biomarkers, Brain, Frontotemporal Dementia, Humans, Magnetic Resonance Imaging, Neuropsychological Tests
Abstract

Objective.The differential diagnosis of behavioral variant frontotemporal dementia (bvFTD) and Alzheimers disease (AD) remains challenging in underrepresented, underdiagnosed groups, including Latinos, as advanced biomarkers are rarely available. Recent guidelines for the study of dementia highlight the critical role of biomarkers. Thus, novel cost-effective complementary approaches are required in clinical settings.Approach. We developed a novel framework based on a gradient boosting machine learning classifier, tuned by Bayesian optimization, on a multi-feature multimodal approach (combining demographic, neuropsychological, magnetic resonance imaging (MRI), and electroencephalography/functional MRI connectivity data) to characterize neurodegeneration using site harmonization and sequential feature selection. We assessed 54 bvFTD and 76 AD patients and 152 healthy controls (HCs) from a Latin American consortium (ReDLat).Main results. The multimodal model yielded high area under the curve classification values (bvFTD patients vs HCs: 0.93 (±0.01); AD patients vs HCs: 0.95 (±0.01); bvFTD vs AD patients: 0.92 (±0.01)). The feature selection approach successfully filtered non-informative multimodal markers (from thousands to dozens).Results. Proved robust against multimodal heterogeneity, sociodemographic variability, and missing data.Significance. The model accurately identified dementia subtypes using measures readily available in underrepresented settings, with a similar performance than advanced biomarkers. This approach, if confirmed and replicated, may potentially complement clinical assessments in developing countries.

Published
2022

19. Brain health in diverse settings: How age, demographics and cognition shape brain function

Author

Hernandez, Hernan, Baez, Sandra, Medel, Vicente, Moguilner, Sebastian, Cuadros, Jhosmary, Santamaria-Garcia, Hernando, Tagliazucchi, Enzo, Valdes-Sosa, Pedro A., Lopera, Francisco, OchoaGómez, John Fredy, González-Hernández, Alfredis, Bonilla-Santos, Jasmin, Gonzalez-Montealegre, Rodrigo A., Aktürk, Tuba, Yıldırım, Ebru, Anghinah, Renato, Legaz, Agustina, Fittipaldi, Sol, Yener, Görsev G., Escudero, Javier, Babiloni, Claudio, Lopez, Susanna, Whelan, Robert, Lucas, Alberto A Fernández, García, Adolfo M., Huepe, David, Caterina, Gaetano Di, Soto-Añari, Marcio, Birba, Agustina, Sainz-Ballesteros, Agustin, Coronel, Carlos, Herrera, Eduar, Abasolo, Daniel, Kilborn, Kerry, Rubido, Nicolás, Clark, Ruaridh, Herzog, Ruben, Yerlikaya, Deniz, Güntekin, Bahar, Parra, Mario A., Prado, Pavel, and Ibanez, Agustin

Published
2024
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20. The relationship between negative life events and cortical structural connectivity in adolescents

Author

Sibilia, Francesca, Jost-Mousseau, Coline, Banaschewski, Tobias, Barker, Gareth J., Büchel, Christian, Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Artiges, Eric, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Poustka, Luise, Millenet, Sabina, Fröhner, Juliane H., Smolka, Michael N., Walter, Henrik, Whelan, Robert, Schumann, Gunter, and Bokde, Arun L.W.

Published
2024
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21. Association between vmPFC gray matter volume and smoking initiation in adolescents

Author

Xiang, Shitong, Jia, Tianye, Xie, Chao, Cheng, Wei, Chaarani, Bader, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Büchel, Christian, Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Gowland, Penny A., Brühl, Rüdiger, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Poustka, Luise, Hohmann, Sarah, Fröhner, Juliane H., Smolka, Michael N., Vaidya, Nilakshi, Walter, Henrik, Whelan, Robert, Garavan, Hugh, Schumann, Gunter, Sahakian, Barbara J., Robbins, Trevor W., and Feng, Jianfeng

Published
2023
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22. Temporo-basal sulcal connections: a manual annotation protocol and an investigation of sexual dimorphism and heritability

Author

de Matos, Kevin, Cury, Claire, Chougar, Lydia, Strike, Lachlan T., Rolland, Thibault, Riche, Maximilien, Hemforth, Lisa, Martin, Alexandre, Banaschewski, Tobias, Bokde, Arun L. W., Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Brühl, Rüdiger, Martinot, Jean-Luc, Paillère Martinot, Marie-Laure, Artiges, Eric, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Lemaitre, Herve, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Millenet, Sabina, Fröhner, Juliane H., Smolka, Michael N., Vaidya, Nilakshi, Walter, Henrik, Whelan, Robert, Schumann, Gunter, Frouin, Vincent, Bach Cuadra, Meritxell, Colliot, Olivier, and Couvy-Duchesne, Baptiste

Published
2023
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25. Reward Processing in Novelty Seekers: A Transdiagnostic Psychiatric Imaging Biomarker.

Author

Qi, Shile, Schumann, Gunter, Bustillo, Juan, Turner, Jessica A, Jiang, Rongtao, Zhi, Dongmei, Fu, Zening, Mayer, Andrew R, Vergara, Victor M, Silva, Rogers F, Iraji, Armin, Chen, Jiayu, Damaraju, Eswar, Ma, Xiaohong, Yang, Xiao, Stevens, Michael, Mathalon, Daniel H, Ford, Judith M, Voyvodic, James, Mueller, Bryon A, Belger, Aysenil, Potkin, Steven G, Preda, Adrian, Zhuo, Chuanjun, Xu, Yong, Chu, Congying, Banaschewski, Tobias, Barker, Gareth J, Bokde, Arun LW, Quinlan, Erin Burke, Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Martinot, Jean-Luc, Paillère Martinot, Marie-Laure, Artiges, Eric, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Fröhner, Juliane H, Smolka, Michael N, Walter, Henrik, Whelan, Robert, Calhoun, Vince D, Sui, Jing, and IMAGEN Consortium

Subjects
IMAGEN Consortium, Humans, Magnetic Resonance Imaging, Reward, Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Major, Adolescent, Adult, Young Adult, Biomarkers, ADHD, Attention-deficit/hyperactivity disorder, MDD, Major depressive disorders, Novelty seeking, Reward processing, Schizophrenia, Substance use, Prevention, Serious Mental Illness, Pediatric, Mental Health, Neurosciences, Brain Disorders, Substance Misuse, Behavioral and Social Science, Depression, Alcoholism, Alcohol Use and Health, Clinical Research, 2.1 Biological and endogenous factors, Aetiology, Mental health, Good Health and Well Being, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

BackgroundDysfunctional reward processing is implicated in multiple mental disorders. Novelty seeking (NS) assesses preference for seeking novel experiences, which is linked to sensitivity to reward environmental cues.MethodsA subset of 14-year-old adolescents (IMAGEN) with the top 20% ranked high-NS scores was used to identify high-NS-associated multimodal components by supervised fusion. These features were then used to longitudinally predict five different risk scales for the same and unseen subjects (an independent dataset of subjects at 19 years of age that was not used in predictive modeling training at 14 years of age) (within IMAGEN, n ≈1100) and even for the corresponding symptom scores of five types of patient cohorts (non-IMAGEN), including drinking (n = 313), smoking (n = 104), attention-deficit/hyperactivity disorder (n = 320), major depressive disorder (n = 81), and schizophrenia (n = 147), as well as to classify different patient groups with diagnostic labels.ResultsMultimodal biomarkers, including the prefrontal cortex, striatum, amygdala, and hippocampus, associated with high NS in 14-year-old adolescents were identified. The prediction models built on these features are able to longitudinally predict five different risk scales, including alcohol drinking, smoking, hyperactivity, depression, and psychosis for the same and unseen 19-year-old adolescents and even predict the corresponding symptom scores of five types of patient cohorts. Furthermore, the identified reward-related multimodal features can classify among attention-deficit/hyperactivity disorder, major depressive disorder, and schizophrenia with an accuracy of 87.2%.ConclusionsAdolescents with higher NS scores can be used to reveal brain alterations in the reward-related system, implicating potential higher risk for subsequent development of multiple disorders. The identified high-NS-associated multimodal reward-related signatures may serve as a transdiagnostic neuroimaging biomarker to predict disease risks or severity.

Published
2021

26. Adolescents’ pain-related ontogeny shares a neural basis with adults’ chronic pain in basothalamo-cortical organization

Author

Heukamp, Nils Jannik, Banaschewski, Tobias, Bokde, Arun L.W., Desrivières, Sylvane, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Kandić, Mina, Brühl, Rüdiger, Martinot, Jean-Luc, Paillère Martinot, Marie-Laure, Artiges, Eric, Papadopoulos Orfanos, Dimitri, Lemaitre, Herve, Löffler, Martin, Poustka, Luise, Hohmann, Sarah, Millenet, Sabina, Fröhner, Juliane H., Smolka, Michael N., Usai, Katrin, Vaidya, Nilakshi, Walter, Henrik, Whelan, Robert, Schumann, Gunter, Flor, Herta, and Nees, Frauke

Published
2024
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29. A shared neural basis underlying psychiatric comorbidity

Author

Xie, Chao, Xiang, Shitong, Shen, Chun, Peng, Xuerui, Kang, Jujiao, Li, Yuzhu, Cheng, Wei, He, Shiqi, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Bromberg, Uli, Büchel, Christian, Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Fröhner, Juliane H., Smolka, Michael N., Walter, Henrik, Whelan, Robert, Sahakian, Barbara J., Robbins, Trevor W., Schumann, Gunter, Jia, Tianye, and Feng, Jianfeng

Published
2023
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30. Federated Analysis in COINSTAC Reveals Functional Network Connectivity and Spectral Links to Smoking and Alcohol Consumption in Nearly 2,000 Adolescent Brains

Author

Gazula, Harshvardhan, Rootes-Murdy, Kelly, Holla, Bharath, Basodi, Sunitha, Zhang, Zuo, Verner, Eric, Kelly, Ross, Murthy, Pratima, Chakrabarti, Amit, Basu, Debasish, Bhagyalakshmi Nanjayya, Subodh, Lenin Singh, Rajkumar, Lourembam Singh, Roshan, Kalyanram, Kartik, Kartik, Kamakshi, Kalyanaraman, Kumaran, Ghattu, Krishnaveni, Kuriyan, Rebecca, Kurpad, Sunita Simon, Barker, Gareth J, Bharath, Rose Dawn, Desrivieres, Sylvane, Purushottam, Meera, Orfanos, Dimitri Papadopoulos, Sharma, Eesha, Hickman, Matthew, Toledano, Mireille, Vaidya, Nilakshi, Banaschewski, Tobias, Bokde, Arun L. W., Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Brühl, Rüdiger, Martinot, Jean-Luc, Paillére Martinot, Marie-Laure, Artiges, Eric, Nees, Frauke, Paus, Tomás, Poustka, Luise, Fröhner, Juliane H., Robinson, Lauren, Smolka, Michael N., Walter, Henrik, Winterer, Jeanne, Whelan, Robert, Turner, Jessica A., Sarwate, Anand D., Plis, Sergey M., Benegal, Vivek, Schumann, Gunter, and Calhoun, Vince D.

Published
2023
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31. Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

Author

Jia, Tianye, Chu, Congying, Liu, Yun, van Dongen, Jenny, Papastergios, Evangelos, Armstrong, Nicola J, Bastin, Mark E, Carrillo-Roa, Tania, den Braber, Anouk, Harris, Mathew, Jansen, Rick, Liu, Jingyu, Luciano, Michelle, Ori, Anil PS, Roiz Santiañez, Roberto, Ruggeri, Barbara, Sarkisyan, Daniil, Shin, Jean, Sungeun, Kim, Tordesillas Gutiérrez, Diana, van’t Ent, Dennis, Ames, David, Artiges, Eric, Bakalkin, Georgy, Banaschewski, Tobias, Bokde, Arun LW, Brodaty, Henry, Bromberg, Uli, Brouwer, Rachel, Büchel, Christian, Burke Quinlan, Erin, Cahn, Wiepke, de Zubicaray, Greig I, Ehrlich, Stefan, Ekström, Tomas J, Flor, Herta, Fröhner, Juliane H, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Hoare, Jacqueline, Ittermann, Bernd, Jahanshad, Neda, Jiang, Jiyang, Kwok, John B, Martin, Nicholas G, Martinot, Jean-Luc, Mather, Karen A, McMahon, Katie L, McRae, Allan F, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Sämann, Philipp G, Schofield, Peter R, Smolka, Michael N, Stein, Dan J, Strike, Lachlan T, Teeuw, Jalmar, Thalamuthu, Anbupalam, Trollor, Julian, Walter, Henrik, Wardlaw, Joanna M, Wen, Wei, Whelan, Robert, Apostolova, Liana G, Binder, Elisabeth B, Boomsma, Dorret I, Calhoun, Vince, Crespo-Facorro, Benedicto, Deary, Ian J, Hulshoff Pol, Hilleke, Ophoff, Roel A, Pausova, Zdenka, Sachdev, Perminder S, Saykin, Andrew, Wright, Margaret J, Thompson, Paul M, Schumann, Gunter, and Desrivières, Sylvane

Subjects
Biological Psychology, Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Psychology, Mental Health, Neurosciences, Genetics, Human Genome, Diabetes, Neurodegenerative, 2.1 Biological and endogenous factors, Aetiology, Neurological, Mental health, CpG Islands, DNA Methylation, Epigenesis, Genetic, Epigenome, Genome-Wide Association Study, Humans, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues than brain, such as blood. A few studies of small sample sizes have revealed associations between blood DNA methylation and neuropsychopathology, however, large-scale epigenome-wide association studies (EWAS) are needed to investigate the utility of DNA methylation profiling as a peripheral marker for the brain. Here, in an analysis of eleven international cohorts, totalling 3337 individuals, we report epigenome-wide meta-analyses of blood DNA methylation with volumes of the hippocampus, thalamus and nucleus accumbens (NAcc)-three subcortical regions selected for their associations with disease and heritability and volumetric variability. Analyses of individual CpGs revealed genome-wide significant associations with hippocampal volume at two loci. No significant associations were found for analyses of thalamus and nucleus accumbens volumes. Cluster-based analyses revealed additional differentially methylated regions (DMRs) associated with hippocampal volume. DNA methylation at these loci affected expression of proximal genes involved in learning and memory, stem cell maintenance and differentiation, fatty acid metabolism and type-2 diabetes. These DNA methylation marks, their interaction with genetic variants and their impact on gene expression offer new insights into the relationship between epigenetic variation and brain structure and may provide the basis for biomarker discovery in neurodegeneration and neuropsychiatric conditions.

Published
2021

32. Correction: Arc controls alcohol cue relapse by a central amygdala mechanism

Author

Pagano, Roberto, Salamian, Ahmad, Zielinski, Janusz, Beroun, Anna, Nalberczak-Skóra, Maria, Skonieczna, Edyta, Cały, Anna, Tay, Nicole, Banaschewski, Tobias, Desrivières, Sylvane, Grigis, Antoine, Garavan, Hugh, Heinz, Andreas, Brühl, Rüdiger, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Artiges, Eric, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Poustka, Luise, Hohmann, Sarah, Fröhner, Juliane H., Smolka, Michael N., Vaidya, Nilakshi, Walter, Henrik, Whelan, Robert, Kalita, Katarzyna, Bito, Haruhiko, Müller, Christian P., Schumann, Gunter, Okuno, Hiroyuki, and Radwanska, Kasia

Published
2024
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33. Cortical profiles of numerous psychiatric disorders and normal development share a common pattern

Author

Cao, Zhipeng, Cupertino, Renata B., Ottino-Gonzalez, Jonatan, Murphy, Alistair, Pancholi, Devarshi, Juliano, Anthony, Chaarani, Bader, Albaugh, Matthew, Yuan, Dekang, Schwab, Nathan, Stafford, James, Goudriaan, Anna E., Hutchison, Kent, Li, Chiang-Shan R., Luijten, Maartje, Groefsema, Martine, Momenan, Reza, Schmaal, Lianne, Sinha, Rajita, van Holst, Ruth J., Veltman, Dick J., Wiers, Reinout W., Porjesz, Bernice, Lett, Tristram, Banaschewski, Tobias, Bokde, Arun L. W., Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Gowland, Penny, Heinz, Andreas, Brühl, Rüdiger, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Artiges, Eric, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Millenet, Sabina, Fröhner, Juliane H., Robinson, Lauren, Smolka, Michael N., Walter, Henrik, Winterer, Jeanne, Schumann, Gunter, Whelan, Robert, Bhatt, Ravi R., Zhu, Alyssa, Conrod, Patricia, Jahanshad, Neda, Thompson, Paul M., Mackey, Scott, and Garavan, Hugh

Published
2023
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34. Arc controls alcohol cue relapse by a central amygdala mechanism

Author

Pagano, Roberto, Salamian, Ahmad, Zielinski, Janusz, Beroun, Anna, Nalberczak-Skóra, Maria, Skonieczna, Edyta, Cały, Anna, Tay, Nicole, Banaschewski, Tobias, Desrivières, Sylvane, Grigis, Antoine, Garavan, Hugh, Heinz, Andreas, Brühl, Rüdiger, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Artiges, Eric, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Poustka, Luise, Hohmann, Sarah, Fröhner, Juliane H., Smolka, Michael N., Vaidya, Nilakshi, Walter, Henrik, Whelan, Robert, Kalita, Katarzyna, Bito, Haruhiko, Müller, Christian P., Schumann, Gunter, Okuno, Hiroyuki, and Radwanska, Kasia

Published
2023
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35. Anxiety onset in adolescents: a machine-learning prediction

Author

Chavanne, Alice V., Paillère Martinot, Marie Laure, Penttilä, Jani, Grimmer, Yvonne, Conrod, Patricia, Stringaris, Argyris, van Noort, Betteke, Isensee, Corinna, Becker, Andreas, Banaschewski, Tobias, Bokde, Arun L. W., Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Brühl, Rüdiger, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Millenet, Sabina, Fröhner, Juliane H., Smolka, Michael N., Walter, Henrik, Whelan, Robert, Schumann, Gunter, Martinot, Jean-Luc, and Artiges, Eric

Published
2023
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36. Trees for brains: Current residential tree cover density and its association with brain structure in young adults

Author

Kühn, Simone, Banaschewski, Tobias, Bokde, Arun L.W., Büchel, Christian, Burke Quinlan, Erin, Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Paillère Martinot, Marie Laure, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Millenet, Sabina, Fröhner, Juliane H., Smolka, Michael N., Walter, Henrik, Whelan, Robert, Schumann, Gunter, Vaidya, Nilakshi, Meyer-Lindenberg, Andreas, and Gallinat, Jürgen

Published
2023
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39. Associations of DNA Methylation With Behavioral Problems, Gray Matter Volumes, and Negative Life Events Across Adolescence: Evidence From the Longitudinal IMAGEN Study

Author

Sun, Yan, Jia, Tianye, Barker, Edward D., Chen, Di, Zhang, Zuo, Xu, Jiayuan, Chang, Suhua, Zhou, Guangdong, Liu, Yun, Tay, Nicole, Luo, Qiang, Chang, Xiao, Banaschewski, Tobias, Bokde, Arun L.W., Flor, Herta, Grigis, Antoine, Garavan, Hugh, Heinz, Andreas, Martinot, Jean-Luc, Paillère Martinot, Marie-Laure, Artiges, Eric, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Millenet, Sabina, Fröhner, Juliane H., Smolka, Michael N., Walter, Henrik, Whelan, Robert, Lu, Lin, Shi, Jie, Schumann, Gunter, and Desrivières, Sylvane

Published
2023
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41. Chronotype, Longitudinal Volumetric Brain Variations Throughout Adolescence, and Depressive Symptom Development

Author

Vulser, Hélène, Lemaître, Hervé S., Guldner, Stella, Bezivin-Frère, Pauline, Löffler, Martin, Sarvasmaa, Anna S., Massicotte-Marquez, Jessica, Artiges, Eric, Paillère Martinot, Marie-Laure, Filippi, Irina, Miranda, Ruben, Stringaris, Argyris, van Noort, Betteke Maria, Penttilä, Jani, Grimmer, Yvonne, Becker, Andreas, Banaschewski, Tobias, Bokde, Arun L.W., Desrivières, Sylvane, Fröhner, Juliane H., Garavan, Hugh, Grigis, Antoine, Gowland, Penny A., Heinz, Andreas, Papadopoulos Orfanos, Dimitri, Poustka, Luise, Smolka, Michael N., Spechler, Philip A., Walter, Henrik, Whelan, Robert, Schumann, Gunter, Flor, Herta, Martinot, Jean-Luc, and Nees, Frauke

Published
2023
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42. Author Correction: A shared neural basis underlying psychiatric comorbidity

Author

Xie, Chao, Xiang, Shitong, Shen, Chun, Peng, Xuerui, Kang, Jujiao, Li, Yuzhu, Cheng, Wei, He, Shiqi, Bobou, Marina, Broulidakis, M. John, van Noort, Betteke Maria, Zhang, Zuo, Robinson, Lauren, Vaidya, Nilakshi, Winterer, Jeanne, Zhang, Yuning, King, Sinead, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Bromberg, Uli, Büchel, Christian, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Lemaître, Hervé, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Fröhner, Juliane H., Schmidt, Ulrike, Sinclair, Julia, Smolka, Michael N., Stringaris, Argyris, Walter, Henrik, Whelan, Robert, Desrivières, Sylvane, Sahakian, Barbara J., Robbins, Trevor W., Schumann, Gunter, Jia, Tianye, and Feng, Jianfeng

Published
2023
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43. Orbitofrontal control of conduct problems? Evidence from healthy adolescents processing negative facial affect

Author

Böttinger, Boris William, Baumeister, Sarah, Millenet, Sabina, Barker, Gareth J., Bokde, Arun L. W., Büchel, Christian, Quinlan, Erin Burke, Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Artiges, Eric, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Fröhner, Juliane H., Smolka, Michael N., Walter, Henrik, Whelan, Robert, Schumann, Gunter, Banaschewski, Tobias, Brandeis, Daniel, and Nees, Frauke

Published
2022
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44. A Developmental Perspective on Facets of Impulsivity and Brain Activity Correlates From Adolescence to Adulthood

Author

Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L.W., Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Brühl, Rüdiger, Martinot, Jean-Luc, Paillère Martinot, Marie-Laure, Artiges, Eric, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Lemaitre, Herve, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Millenet, Sabina, Fröhner, Juliane H., Robinson, Lauren, Smolka, Michael N., Walter, Henrik, Winterer, Jeanne M., Whelan, Robert, Schumann, Gunter, Kaiser, Anna, Holz, Nathalie E., Baumeister, Sarah, Ittermann, Bernd, Schwarz, Emanuel, and Brandeis, Daniel

Published
2022
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45. Brain Signatures During Reward Anticipation Predict Persistent Attention-Deficit/Hyperactivity Disorder Symptoms

Author

Jia, Tianye, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L.W., Bromberg, Uli, Büchel, Christian, Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Paillère Martinot, Marie-Laure, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Fröhner, Juliane H., Smolka, Michael N., Walter, Henrik, Whelan, Robert, Schumann, Gunter, Chen, Di, Cheng, Wei, Cao, Miao, Gowland, Penny A., Robbins, T.W., Sahakian, Barbara J., and Feng, Jianfeng

Published
2022
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47. Genetic variants associated with longitudinal changes in brain structure across the lifespan

Author

Brouwer, Rachel M., Klein, Marieke, Grasby, Katrina L., Schnack, Hugo G., Jahanshad, Neda, Teeuw, Jalmar, Thomopoulos, Sophia I., Sprooten, Emma, Franz, Carol E., Gogtay, Nitin, Kremen, William S., Panizzon, Matthew S., Olde Loohuis, Loes M., Whelan, Christopher D., Aghajani, Moji, Alloza, Clara, Alnæs, Dag, Artiges, Eric, Ayesa-Arriola, Rosa, Barker, Gareth J., Bastin, Mark E., Blok, Elisabet, Bøen, Erlend, Breukelaar, Isabella A., Bright, Joanna K., Buimer, Elizabeth E. L., Bülow, Robin, Cannon, Dara M., Ciufolini, Simone, Crossley, Nicolas A., Damatac, Christienne G., Dazzan, Paola, de Mol, Casper L., de Zwarte, Sonja M. C., Desrivières, Sylvane, Díaz-Caneja, Covadonga M., Doan, Nhat Trung, Dohm, Katharina, Fröhner, Juliane H., Goltermann, Janik, Grigis, Antoine, Grotegerd, Dominik, Han, Laura K. M., Harris, Mathew A., Hartman, Catharina A., Heany, Sarah J., Heindel, Walter, Heslenfeld, Dirk J., Hohmann, Sarah, Ittermann, Bernd, Jansen, Philip R., Janssen, Joost, Jia, Tianye, Jiang, Jiyang, Jockwitz, Christiane, Karali, Temmuz, Keeser, Daniel, Koevoets, Martijn G. J. C., Lenroot, Rhoshel K., Malchow, Berend, Mandl, René C. W., Medel, Vicente, Meinert, Susanne, Morgan, Catherine A., Mühleisen, Thomas W., Nabulsi, Leila, Opel, Nils, de la Foz, Víctor Ortiz-García, Overs, Bronwyn J., Paillère Martinot, Marie-Laure, Redlich, Ronny, Marques, Tiago Reis, Repple, Jonathan, Roberts, Gloria, Roshchupkin, Gennady V., Setiaman, Nikita, Shumskaya, Elena, Stein, Frederike, Sudre, Gustavo, Takahashi, Shun, Thalamuthu, Anbupalam, Tordesillas-Gutiérrez, Diana, van der Lugt, Aad, van Haren, Neeltje E. M., Wardlaw, Joanna M., Wen, Wei, Westeneng, Henk-Jan, Wittfeld, Katharina, Zhu, Alyssa H., Zugman, Andre, Armstrong, Nicola J., Bonfiglio, Gaia, Bralten, Janita, Dalvie, Shareefa, Davies, Gail, Di Forti, Marta, Ding, Linda, Donohoe, Gary, Forstner, Andreas J., Gonzalez-Peñas, Javier, Guimaraes, Joao P. O. F. T., Homuth, Georg, Hottenga, Jouke-Jan, Knol, Maria J., Kwok, John B. J., Le Hellard, Stephanie, Mather, Karen A., Milaneschi, Yuri, Morris, Derek W., Nöthen, Markus M., Papiol, Sergi, Rietschel, Marcella, Santoro, Marcos L., Steen, Vidar M., Stein, Jason L., Streit, Fabian, Tankard, Rick M., Teumer, Alexander, van ‘t Ent, Dennis, van der Meer, Dennis, van Eijk, Kristel R., Vassos, Evangelos, Vázquez-Bourgon, Javier, Witt, Stephanie H., Adams, Hieab H. H., Agartz, Ingrid, Ames, David, Amunts, Katrin, Andreassen, Ole A., Arango, Celso, Banaschewski, Tobias, Baune, Bernhard T., Belangero, Sintia I., Bokde, Arun L. W., Boomsma, Dorret I., Bressan, Rodrigo A., Brodaty, Henry, Buitelaar, Jan K., Cahn, Wiepke, Caspers, Svenja, Cichon, Sven, Crespo-Facorro, Benedicto, Cox, Simon R., Dannlowski, Udo, Elvsåshagen, Torbjørn, Espeseth, Thomas, Falkai, Peter G., Fisher, Simon E., Flor, Herta, Fullerton, Janice M., Garavan, Hugh, Gowland, Penny A., Grabe, Hans J., Hahn, Tim, Heinz, Andreas, Hillegers, Manon, Hoare, Jacqueline, Hoekstra, Pieter J., Ikram, Mohammad A., Jackowski, Andrea P., Jansen, Andreas, Jönsson, Erik G., Kahn, Rene S., Kircher, Tilo, Korgaonkar, Mayuresh S., Krug, Axel, Lemaitre, Herve, Malt, Ulrik F., Martinot, Jean-Luc, McDonald, Colm, Mitchell, Philip B., Muetzel, Ryan L., Murray, Robin M., Nees, Frauke, Nenadić, Igor, Oosterlaan, Jaap, Ophoff, Roel A., Pan, Pedro M., Penninx, Brenda W. J. H., Poustka, Luise, Sachdev, Perminder S., Salum, Giovanni A., Schofield, Peter R., Schumann, Gunter, Shaw, Philip, Sim, Kang, Smolka, Michael N., Stein, Dan J., Trollor, Julian N., van den Berg, Leonard H., Veldink, Jan H., Walter, Henrik, Westlye, Lars T., Whelan, Robert, White, Tonya, Wright, Margaret J., Medland, Sarah E., Franke, Barbara, Thompson, Paul M., and Hulshoff Pol, Hilleke E.

Published
2022
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49. Bayesian causal network modeling suggests adolescent cannabis use accelerates prefrontal cortical thinning

Author

Owens, Max M., Albaugh, Matthew D., Allgaier, Nicholas, Yuan, Dekang, Robert, Gabriel, Cupertino, Renata B., Spechler, Philip A., Juliano, Anthony, Hahn, Sage, Banaschewski, Tobias, Bokde, Arun L. W., Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Gowland, Penny, Heinz, Andreas, Brühl, Rüdiger, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Artiges, Eric, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Lemaitre, Herve, Paus, Tomáš, Poustka, Luise, Millenet, Sabina, Fröhner, Juliane H., Smolka, Michael N., Walter, Henrik, Whelan, Robert, Mackey, Scott, Schumann, Gunter, and Garavan, Hugh

Published
2022
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