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665 results on '"Whang-Peng J"'

1. Molecular Pathogenesis of Lung Cancer : Mutations in Dominant and Recessive Oncogenes, and the Expression of Opioid and Nicotine Receptors in the Pathogenesis of Lung Cancer

Author

Carbone, D., Maneckjee, R., D’Amico, D., Bader, S., Bodner, S., Chiba, I., Fedorko, J., Linnoila, I., Mitsudomi, T., Nau, M., Pass, H., Oie, H., Russell, E., Takahashi, T., Unger, T., Whang-Peng, J., Gazdar, A., Minna, J., Rhim, Johng S., editor, and Dritschilo, Anatoly, editor

Published
1991
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23. Chromosome studies in HTLV-I, -II, and HIV-1, -2 cell lines infected with in vivo and in vitro

Author

Whang-Peng, J., Chen, Y.M.A., Knutsen, T., Zhao, W.-P., and Tsai, S.

Subjects
HTLV-I (Virus) -- Genetic aspects, HTLV-II (Virus) -- Genetic aspects, HIV (Viruses) -- Genetic aspects, Health
Abstract

Different types of chromosomal changes may occur in cells infected with human T cell lymphotrophic virus (HTLV) or HIV. HTLV and HIV are both retroviruses, and they both infect T cells. A chromosomal study was done of cells infected with HTLV-I, HTLV-II, HIV-1 and HIV-2. Cells infected with HTLV had multiple types of chromosomal changes. A high incidence of abnormalities occurred in a specific region of chromosome 6. Cells infected with HTLV-2 had abnormalities that affected chromosomes 20 and 21. In the cells infected with HIV-1, chromosomal abnormalities occurred most often in chromosome 17. A high incidence of chromosomal changes also occurred in chromosomes 3 and 21 in the cells infected with HIV-1. Cells infected with HIV-2 did not have any unique chromosomal changes.

Published
1993

25. Cytogenetics of Human Small Cell Lung Cancer

Author

Whang-Peng, J., Lee, E. C., Herfarth, Ch., editor, Senn, H. J., editor, Baum, M., editor, von Essen, C., editor, Diehl, V., editor, Hitzig, W., editor, Rajewsky, M. F., editor, Thomas, C., editor, and Seeber, Siegfried, editor

Published
1985
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28. A randomised phase II study of weekly paclitaxel or vinorelbine in combination with cisplatin against inoperable non-small-cell lung cancer previously untreated

Author

Yu-Chin Lee, C.-S. Lee, Reury-Perng Perng, Yuh Min Chen, Jen-Fu Shih, Whang-Peng J, and Chun Ming Tsai

Subjects
Adult, Male, myalgia, Cancer Research, medicine.medical_specialty, Lung Neoplasms, Randomization, Paclitaxel, Urology, cisplatin, Phases of clinical research, Vinblastine, Vinorelbine, Disease-Free Survival, Drug Administration Schedule, Clinical, chemistry.chemical_compound, Carcinoma, Non-Small-Cell Lung, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Infusions, Intravenous, Lung cancer, Aged, Cisplatin, Dose-Response Relationship, Drug, business.industry, Middle Aged, medicine.disease, Surgery, non-small-cell lung cancer, Oncology, chemistry, Female, medicine.symptom, business, medicine.drug
Abstract

Phase II studies have suggested that weekly paclitaxel has a higher response rate and better toxicity profile than the conventional schedule of once every 3 or 4 weeks. Our aim was to evaluate the efficacy of weekly paclitaxel plus cisplatin (PC) vs vinorelbine plus cisplatin (VC) in chemonaïve non-small-cell lung cancer (NSCLC) patients. From October 2000 to May 2002, 140 patients were enrolled. The treatment dose was P 66 mg m(-2) intravenous infusion (i.v.) on days 1, 8, and 15, and C 60 mg m(-2) i.v. on day 15, or V 23 mg m(-2) i.v. on days 1, 8, and 15, and C 60 mg m(-2) i.v. on day 15, every 4 weeks. In all, 281 cycles of PC and 307 cycles of VC were given to the patients in the PC and VC arms, respectively. There were 26 partial responses and one complete response (overall 38.6%) in the PC arm, and no complete responses, but 27 partial responses (overall 38.6%) in the VC arm. Myelosuppression was more common in the VC arm (P0.001). Peripheral neuropathy and myalgia were significantly more common in the PC arm (P0.001). The median time to disease progression was 6 months in the PC arm and 8.4 months in the VC arm (P=0.0344). The median survival time was 11.7 months in the PC arm and 15.4 months in the VC arm (P=0.297). We concluded that weekly PC is not suggested for NSCLC patients due to the relatively shorter progression-free survival and more common nonhaematological toxicities. British Journal of Cancer (2004) 90, 359-365. doi:10.1038/sj.bjc.6601526 www.bjcancer.com

Published
2004

35. Molecular genetic characterization of neuroendocrine lung cancer cell lines

Author

Sl, Lai, Hiltrud Brauch, Knutsen T, Be, Johnson, Mm, Nau, Mitsudomi T, Cm, Tsai, Whang-Peng J, Zbar B, and Fj, Kaye

Subjects
Chromosome Aberrations, Lung Neoplasms, Bronchial Neoplasms, Antineoplastic Agents, Carcinoid Tumor, Aneuploidy, Genes, p53, Drug Resistance, Multiple, Genes, ras, Carcinoma, Non-Small-Cell Lung, Tumor Cells, Cultured, Chromosomes, Human, Humans, Carcinoma, Small Cell, Genes, Retinoblastoma, DNA Probes, Polymorphism, Restriction Fragment Length, Sequence Deletion
Abstract

Small cell lung cancers express neuroendocrine (NE) cell features, while most non-SCLC tumors lack these features. We studied the cytogenetic and genetic alterations in cell lines derived from three unusual subtypes of lung cancer: including carcinoids, non-small cell lung cancers expressing NE properties (NSCLC-NE) and extrapulmonary small cell cancers (ExPuSC) and compared them with those of SCLC and NSCLC lines. Our studies included: cytogenetic studies, restriction fragment length polymorphism (RFLP) analyses with 8 probes spanning commonly deleted loci on chromosomes 3p, 13q and 17p, retinoblastoma gene product (RB) expression, and mutations in the ras and p53 genes. We also summarize previously published data on in vitro chemosensitivity patterns and MDRl gene expression. Our studies demonstrate that all three of the NE cell subtypes have their own distinctive genotypes and phenotypes, each having some similarities and dissimilarities with SCLC and NSCLC.

Published
1995

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