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2. Human scattered tubular cells represent a heterogeneous population of glycolytic dedifferentiated proximal tubule cells

Author

Eymael, Jennifer, van den Broek, Martijn, Miesen, Laura, Monge, Valerie Villacorta, van den Berge, Bartholomeus T., Mooren, Fieke, Velez, Vicky Luna, Dijkstra, Jelmer, Hermsen, Meyke, Bándi, Péter, Vermeulen, Michiel, de Wildt, Saskia, Willemsen, Brigith, Florquin, Sandrine, Wetzels, Roy, Steenbergen, Eric, Kramann, Rafael, Moeller, Marcus, Schreuder, Michiel F., Wetzels, Jack F.M., van der Vlag, Johan, Jansen, Jitske, Smeets, Bart, Eymael, Jennifer, van den Broek, Martijn, Miesen, Laura, Monge, Valerie Villacorta, van den Berge, Bartholomeus T., Mooren, Fieke, Velez, Vicky Luna, Dijkstra, Jelmer, Hermsen, Meyke, Bándi, Péter, Vermeulen, Michiel, de Wildt, Saskia, Willemsen, Brigith, Florquin, Sandrine, Wetzels, Roy, Steenbergen, Eric, Kramann, Rafael, Moeller, Marcus, Schreuder, Michiel F., Wetzels, Jack F.M., van der Vlag, Johan, Jansen, Jitske, and Smeets, Bart

Published
2023

3. Human scattered tubular cells represent a heterogeneous population of glycolytic dedifferentiated proximal tubule cells

Author

Eymael, Jennifer, primary, van den Broek, Martijn, additional, Miesen, Laura, additional, Monge, Valerie Villacorta, additional, van den Berge, Bartholomeus T, additional, Mooren, Fieke, additional, Velez, Vicky Luna, additional, Dijkstra, Jelmer, additional, Hermsen, Meyke, additional, Bándi, Péter, additional, Vermeulen, Michiel, additional, de Wildt, Saskia, additional, Willemsen, Brigith, additional, Florquin, Sandrine, additional, Wetzels, Roy, additional, Steenbergen, Eric, additional, Kramann, Rafael, additional, Moeller, Marcus, additional, Schreuder, Michiel F, additional, Wetzels, Jack FM, additional, van der Vlag, Johan, additional, Jansen, Jitske, additional, and Smeets, Bart, additional

Published
2022
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4. Parietal epithelial cells maintain the epithelial cell continuum forming Bowman's space in focal segmental glomerulosclerosis

Author

Miesen, L., Bándi, P., Schreven-Willemsen, B.K.T., Mooren, F., Strieder, Thiago, Boldrini, Eva, Eymael, J., Wetzels, Roy, Steenbergen, E., Kuppevelt, T.H. van, Erp, M. van, Laak, J.A.W.M. van der, Wetzels, J.F.M., Jansen, J., Smeets, B., Miesen, L., Bándi, P., Schreven-Willemsen, B.K.T., Mooren, F., Strieder, Thiago, Boldrini, Eva, Eymael, J., Wetzels, Roy, Steenbergen, E., Kuppevelt, T.H. van, Erp, M. van, Laak, J.A.W.M. van der, Wetzels, J.F.M., Jansen, J., and Smeets, B.

Abstract

Contains fulltext : 249325.pdf (Publisher’s version ) (Open Access)

Published
2022

5. Human pluripotent stem cell-derived kidney organoids for personalized congenital and idiopathic nephrotic syndrome modeling

Author

Jansen, J., Berge, B.T. van den, Broek, M.L. van den, Maas, R.J.H., Daviran, D., Willemsen, B.K., Roverts, R.C., Giovanni, G.L.V. Di, Mooren, F., Wetzels, Roy, Parr, N.M.J., Steenbergen, E., Nijenhuis, T., Dijkman, H.B., Kar, N.C.A.J. van de, Wetzels, J.F.M., Akiva, A., Vlag, J. van der, Schreuder, M.F., Smeets, B., Jansen, J., Berge, B.T. van den, Broek, M.L. van den, Maas, R.J.H., Daviran, D., Willemsen, B.K., Roverts, R.C., Giovanni, G.L.V. Di, Mooren, F., Wetzels, Roy, Parr, N.M.J., Steenbergen, E., Nijenhuis, T., Dijkman, H.B., Kar, N.C.A.J. van de, Wetzels, J.F.M., Akiva, A., Vlag, J. van der, Schreuder, M.F., and Smeets, B.

Abstract

Item does not contain fulltext

Published
2022

6. Human pluripotent stem cell-derived kidney organoids for personalized congenital and idiopathic nephrotic syndrome modeling

Author

Jansen, Jitske, primary, van den Berge, Bartholomeus T., additional, van den Broek, Martijn, additional, Maas, Rutger J., additional, Daviran, Deniz, additional, Willemsen, Brigith, additional, Roverts, Rona, additional, van der Kruit, Marit, additional, Kuppe, Christoph, additional, Reimer, Katharina C., additional, Di Giovanni, Gianluca, additional, Mooren, Fieke, additional, Nlandu, Quincy, additional, Mudde, Helmer, additional, Wetzels, Roy, additional, den Braanker, Dirk, additional, Parr, Naomi, additional, Nagai, James S., additional, Drenic, Vedran, additional, Costa, Ivan G., additional, Steenbergen, Eric, additional, Nijenhuis, Tom, additional, Dijkman, Henry, additional, Endlich, Nicole, additional, van de Kar, Nicole C. A. J., additional, Schneider, Rebekka K., additional, Wetzels, Jack F. M., additional, Akiva, Anat, additional, van der Vlag, Johan, additional, Kramann, Rafael, additional, Schreuder, Michiel F., additional, and Smeets, Bart, additional

Published
2022
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7. Parietal epithelial cells maintain the epithelial cell continuum forming Bowman's space in focal segmental glomerulosclerosis

Author

Miesen, Laura, primary, Bándi, Péter, additional, Willemsen, Brigith, additional, Mooren, Fieke, additional, Strieder, Thiago, additional, Boldrini, Eva, additional, Drenic, Vedran, additional, Eymael, Jennifer, additional, Wetzels, Roy, additional, Lotz, Johannes, additional, Weiss, Nick, additional, Steenbergen, Eric, additional, van Kuppevelt, Toin H., additional, van Erp, Merijn, additional, van der Laak, Jeroen, additional, Endlich, Nicole, additional, Moeller, Marcus J., additional, Wetzels, Jack F.M., additional, Jansen, Jitske, additional, and Smeets, Bart, additional

Published
2021
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8. Human pluripotent stem cell-derived kidney organoids for personalized congenital and idiopathic nephrotic syndrome modeling

Author

Jansen, Jitske, primary, van den Berge, Bartholomeus T, additional, van den Broek, Martijn, additional, Maas, Rutger J, additional, Willemsen, Brigith, additional, Kuppe, Christoph, additional, Reimer, Katharina C, additional, Giovanni, Gianluca Di, additional, Mooren, Fieke, additional, Nlandu, Quincy, additional, Mudde, Helmer, additional, Wetzels, Roy, additional, den Braanker, Dirk, additional, Parr, Naomi, additional, Nagai, James S, additional, Drenic, Vedran, additional, Costa, Ivan G, additional, Steenbergen, Eric, additional, Nijenhuis, Tom, additional, Endlich, Nicole, additional, van de Kar, Nicole CAJ, additional, Schneider, Rebekka K, additional, Wetzels, Jack FM, additional, van der Vlag, Johan, additional, Kramann, Rafael, additional, Schreuder, Michiel F, additional, and Smeets, Bart, additional

Published
2021
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9. Establishment and characterization of a novel conditionally immortalized human parietal epithelial cell line

Author

Miesen, L., Wetzels, Roy, Eymael, J., Mooren, F., Monge, Valerie Villacorta, Berge, B.T. van den, Broek, M.L. van den, Velden, T.J.A.M. van der, Heuvel, L.P.W.J. van den, Wetzels, J.F.M., Schreuder, M.F., Vlag, J. van der, Jansen, J., Smeets, B., Miesen, L., Wetzels, Roy, Eymael, J., Mooren, F., Monge, Valerie Villacorta, Berge, B.T. van den, Broek, M.L. van den, Velden, T.J.A.M. van der, Heuvel, L.P.W.J. van den, Wetzels, J.F.M., Schreuder, M.F., Vlag, J. van der, Jansen, J., and Smeets, B.

Abstract

Contains fulltext : 236828.pdf (Publisher’s version ) (Open Access)

Published
2021

11. Parietal epithelial cells maintain the epithelial cell continuum forming Bowman's space in focal segmental glomerulosclerosis

Author

Miesen, Laura, Bándi, Péter, Willemsen, Brigith, Mooren, Fieke, Strieder, Thiago, Boldrini, Eva, Drenic, Vedran, Eymael, Jennifer, Wetzels, Roy, Lotz, Johannes, Weiss, Nick, Steenbergen, Eric, van Kuppevelt, Toin H., van Erp, Merijn, van der Laak, Jeroen, Endlich, Nicole, Moeller, Marcus J., Wetzels, Jack F. M., Jansen, Jitske, and Smeets, Bart

Abstract

In the glomerulus, Bowman's space is formed by a continuum of glomerular epithelial cells. In focal segmental glomerulosclerosis (FSGS), glomeruli show segmental scarring, a result of activated parietal epithelial cells (PECs) invading the glomerular tuft. The segmental scars interrupt the epithelial continuum. However, non-sclerotic segments seem to be preserved even in glomeruli with advanced lesions. We studied the histology of the segmental pattern in Munich Wistar Frömter rats, a model for secondary FSGS. Our results showed that matrix layers lined with PECs cover the sclerotic lesions. These PECs formed contacts with podocytes of the uninvolved tuft segments, restoring the epithelial continuum. Formed Bowman's spaces were still connected to the tubular system. In biopsies of patients with secondary FSGS, we also detected matrix layers formed by PECs, separating the uninvolved from the sclerotic glomerular segments. PECs have a major role in the formation of glomerulosclerosis; we show here that in FSGS they also restore the glomerular epithelial cell continuum that surrounds Bowman's space. This process may be beneficial and indispensable for glomerular filtration in the uninvolved segments of sclerotic glomeruli.

Published
2022
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12. Human scattered tubular cells represent a heterogeneous population of glycolytic dedifferentiated proximal tubule cells.

Author

Eymael J, van den Broek M, Miesen L, Monge VV, van den Berge BT, Mooren F, Velez VL, Dijkstra J, Hermsen M, Bándi P, Vermeulen M, de Wildt S, Willemsen B, Florquin S, Wetzels R, Steenbergen E, Kramann R, Moeller M, Schreuder MF, Wetzels JF, van der Vlag J, Jansen J, and Smeets B

Subjects
Humans, Kidney metabolism, Epithelial Cells, Glycolysis, Kidney Tubules, Proximal pathology, Acute Kidney Injury metabolism
Abstract

Scattered tubular cells (STCs) are a phenotypically distinct cell population in the proximal tubule that increase in number after acute kidney injury. We aimed to characterize the human STC population. Three-dimensional human tissue analysis revealed that STCs are preferentially located within inner bends of the tubule and are barely present in young kidney tissue (<2 years), and their number increases with age. Increased STC numbers were associated with acute tubular injury (kidney injury molecule 1) and interstitial fibrosis (alpha smooth muscle actin). Isolated CD13 + CD24 - CD133 - proximal tubule epithelial cells (PTECs) and CD13 + CD24+ and CD13 + CD133 + STCs were analyzed using RNA sequencing. Transcriptome analysis revealed an upregulation of nuclear factor κB, tumor necrosis factor alpha, and inflammatory pathways in STCs, whereas metabolism, especially the tricarboxylic acid cycle and oxidative phosphorylation, was downregulated, without showing signs of cellular senescence. Using immunostaining and a publicly available single-cell sequencing database of human kidneys, we demonstrate that STCs represent a heterogeneous population in a transient state. In conclusion, STCs are dedifferentiated PTECs showing a metabolic shift toward glycolysis, which could facilitate cellular survival after kidney injury. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland., (© 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.)

Published
2023
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