134 results on '"Westrich G"'
Search Results
2. Recommendations from the ICM-VTE: General
- Author
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Parvizi, J., Abbas, A. A., Abcha, O., Abdelaal, M. S., Ackermann, P. W., Acuna, A. J., Ageno, W., Aguilar Ramirez, J. J., Akkaya, M., Alameddine, D., Alfaro, D. O., Alvand, A., Alzeedi, M., Andrade, A. J., Arnold, W. V., Arish, A., Austin, M. S., Ay, C., Azboy, I., Babis, G. C., Baker, C. M., Barrack, R. L., Barragan, E., Beaton-Comulada, D., Bedair, H. S., Bell, J. A., Beverland, D. E., Bhatia, N., Bialecki, J., Bondarenko, S., Bonilla, G., River Boschert, S. O., Bracho, C., Brooks, D., Buttaro, M., Cacan Daniel Caldeira, M. A., Callaghan, J., Campbell, D. G., Cancienne, J. M., Cannegieter, S. C., Canseco, J. A., Caprini, J. A., Carrier, M., Castro Bejarano, J. C., Catani, F., Ceylan, H. H., Cha, Y. -H., Chan, C. K., Chan, N., Cheung, M. H., Chisari, E., Cimminiello, C., Citak, M., Colon-Miranda, R. G., Colwell, C., Combs, K., Cordeiro, M., Corvi, J. J., Courtney Crispiana Cozowicz, P. M., Crawford, R. W., Cruz, E., D'Amore, T., Dantas, P., Della Valle, A. G., Deltour, C., Demanes, A. C., Djaja, Y. P., Dunbar, M. J., Egoavil, M. S., Egol, K. A., Eichinger, S., Elias, L. F., Emmerson, B. R., Ettema, H. B., Al Farii, H., Fernandez-Rodriguez, D., Fillingham, Y. A., Fu, H., Gallagher, N., Gary, J. L., Geerts, W. H., Ghazavi, M. T., Gleason, B., Goh, G. S., Goncalves, S., Goriainov, V., Goswami, K., Goyal, L., Granqvist, M., Grenho, A., Griffin, X., Hafez, M. A., Hakyemez, O. S., Hamdi, S., Hansen, E. N., Hansen, H., Hasegawa, M., Higuera, C. A., Hobohm, L. M. A., Holc, F., Hollingsworth, N., Hozack, W. J., Hughes, A. J., Humphrey, T. J., Huo, M. H., Inaba, Y., Jenny, J. -Y., Jiranek, W., Kaila, R., Kallel, S., Kamath, A. F., Karachalios, T., Karas, V., Kelkar, A. H., Keller, K., Kenanidis, E., Khan, I. A., Khan, Y., Kim, J. -H., Kim, K. -I., Klein, G. R., Kleiner, J. E., Komnos, G., Konstantinides, S. V., Koo, K. -H., Kopenitz, J., Krasinski, Z., Krueger, C. A., Kuo, A., Kvederas, G., Kwong, L. M., Lachiewicz, P. F., De Ladoucette, A., Larco, E., Larkin, J. A., Levine, B. R., W. T., Li, Lieberman, J. R., Lip, G. Y. H., Lizarraga, M. M., Llinas, A., Lobastov, K., Lobo, C. A., Ludwick, L., Julian, F., Maempel, Magnuson, J., Maini, L., Maltseva, V., Mamczak, C. N., Garcia-Mansilla, A., Manzaneda, M. E., Martino, V., Al Maskari, S., Matharu, G. S., Mead, M., Meghpara, M. M., Mehta, S., Memtsoudis, S. G., Menon, D., Merli Nikolaos Milonakis, G. J., Mirkazemi, C., Mojica, J. J., Moka, E., Moncman, T. G., Monsalvo, D., Mortazavi, S. M. J., Morton, J., Mulcahey, M. K., Najafi, F., Nam, D., Namdari, S., Navarro, R., Nazarian, D. G., Niikura, T., Noyez, J. F., Ochoa Chaar, C. I., Ong, C. B., Otero-Lopez, A., Ozaki, T., Pandit, H., Pannu, T. S., Parvizi, N., Poeran, J., Poolman, R. W., Purtill, J. J., Radoicic, D. K., Rajasekaran, R. B., Rajasekhar, A., Randelli, F., Reed, M., Restrepo, C., Riva, N., Romanini, E., Sadek, M., Saglam, Y., Salazar, G., Salazar, M., Salvati, E. A., Samama, C. M., Sanchez-Osorio, J. S., Santoso, A., Sattarzadeh, R., Saxena, A., Schemitsch, E., Schulman, S., Schwenk, E. S., Shahi, A., Sharkey, P. F., Sharrock, N., Shivakumar, S., Shohat, N., Siegel, N. M., Sievers, D. A., Smailys, A., Smith, E. B., Somers, J. F. A., Souissi, M., Sousa, P., Sousa, R., Spyropoulos, A. C., Squizzato, A., Srivastava, A., Suarez, C., Suresh, S., Tannoury, T., Tarabichi, M., Tarabichi, S., Taylor, J., Terhune, E. B., Thienpont, E., Thomas, T. L., Top, A. C., Tornetta, P., Torres, A., Torres-Lugo, N. J., Tort-Saade, P., Tresgallo-Pares, R., Tsiridis, E., Tuncay, I., Urbanek, T., Urish, K. L., Vendittoli, P. -A., Victor, K., Vilchez, F., Villa, J. M., Viscusi, E. R., Volk, T., Vosooghi, F., Vysotskyi, O., Walsh, M., Warren, J., Werner, B. C., Westrich, G., Whitehouse, M. R., Whitehouse, S. L., Winters, B. S., Wouthuyzen-Bakker, M., Yamada, K., Yates, A. J., Yoo, J. -I., Yoon, U., Zambianchi, F., UCL - SSS/IREC/NMSK - Neuro-musculo-skeletal Lab, UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, and Delegates, ICM-VTE General
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Risk Factors ,Anticoagulants ,Humans ,Orthopedics and Sports Medicine ,Surgery ,General Medicine ,Venous Thromboembolism - Published
- 2022
3. Pregabalin and pain after total knee arthroplasty: a double-blind, randomized, placebo-controlled, multidose trial†
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YaDeau, J. T., Lin, Y., Mayman, D. J., Goytizolo, E. A., Alexiades, M. M., Padgett, D. E., Kahn, R. L., Jules-Elysee, K. M., Ranawat, A. S., Bhagat, D. D., Fields, K. G., Goon, A. K., Curren, J., and Westrich, G. H.
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- 2015
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4. Analgesia after total knee replacement: local infiltration versus epidural combined with a femoral nerve blockade A PROSPECTIVE, RANDOMISED PRAGMATIC TRIAL
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YaDeau, J. T., Goytizolo, E. A., Padgett, D. E., Liu, S. S., Mayman, D. J., Ranawat, A. S., Rade, M. C., and Westrich, G. H.
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- 2013
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5. Thromboseprophylaxe in der Hüftendoprothetik
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Böttner, F., Sculco, T. P., Sharrock, N. E., Westrich, G. H., and Steinbeck, J.
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- 2001
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6. Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage
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Sivakumar, P V, Westrich, G M, Kanaly, S, Garka, K, Born, T L, Derry, J M J, and Viney, J L
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- 2002
7. The effect of preoperative donation of autologous blood on deep-vein thrombosis after total hip arthroplasty
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Bae, H., Westrich, G. H., Sculco, T. P., Salvati, E. A., and Reich, L. M.
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- 2001
8. Meta-analysis of thromboembolic prophylaxis after total knee arthroplasty
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WESTRICH, G. H.
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- 2001
9. Meta-analysis of thromboembolic prophylaxis after total knee arthroplasty
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Westrich, G. H., Haas, S. B., Mosca, P., and Peterson, M.
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- 2000
10. Venous haemodynamics after total knee arthroplasty: EVALUATION OF ACTIVE DORSAL TO PLANTAR FLEXION AND SEVERAL MECHANICAL COMPRESSION DEVICES
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Westrich, G. H., Specht, L. M., Sharrock, N. E., Windsor, R. E., Sculco, T. P., Haas, S. B., Trombley, J. F., and Peterson, M.
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- 1998
11. Tiefe Beinvenenthrombosen nach Implantation von unikondylären Knieprothesen - Wie hoch ist die Inzidenz wirklich?
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Schmidt-Bräkling, T, Pearle, A, Mayman, DJ, Westrich, G, Waldstein, W, Böttner, F, Schmidt-Bräkling, T, Pearle, A, Mayman, DJ, Westrich, G, Waldstein, W, and Böttner, F
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- 2018
12. 3:18 PM Abstract No. 203 Selective geniculate artery embolization for management of recurrent hemarthrosis after total-knee arthroplasty
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Cornman-Homonoff, J., primary, Kishore, S., additional, Waddell, B., additional, Westrich, G., additional, Potter, H., additional, and Trost, D., additional
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- 2018
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13. Tibiofemorale Kontaktmechanik nach Unikompartmentellem Kniegelenkersatz
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Heyse, TJ, Tucker, S, Rajak, Y, Lipman, J, Imhauser, C, and Westrich, G
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ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Fragestellung: Die Hauptursachen, die zur Revision von unikopartimentellem Gelenkersatz am Kniegelenk (UKA) führen, sind Lockerung der Komponenten und Fortschreiten der Arthrose im erhaltenen Gelenkanteil. Die Veränderungen der tibiofemoralen Kontaktmechanik nach UKA spielt bei diesen Prozessen[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2014)
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- 2014
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14. Pregabalin and Pain After Total Knee Arthroplasty
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YaDeau, J. T., primary, Lin, Y., additional, Mayman, D. J., additional, Goytizolo, E. A., additional, Alexiades, M. M., additional, Padgett, D. E., additional, Kahn, R. L., additional, Jules-Elysee, K. M., additional, Ranawat, A. S., additional, Bhagat, D. D., additional, Fields, K. G., additional, Goon, A. K., additional, Curren, J., additional, and Westrich, G. H., additional
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- 2016
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15. 95 HERITABLE THROMBOPHILIA AND DEVELOPMENT OF THROMBOEMBOLIC DISEASE FOLLOWING TOTAL HIP ARTHROPLASTY
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Salvati, E. A., primary, Della Valle, Gonzalez A., additional, Westrich, G., additional, Rang, A. J., additional, Specht, L., additional, Weksler, B. B., additional, Wang, P., additional, and Glueck, C. J., additional
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- 2005
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16. 60 COST-BENEFIT ANALYSIS OF 3 STRATEGIES TO DEAL WITH POST TOTAL HIP REPLACEMENT (THR) PULMONARY EMBOLI-DEEP VENOUS THROMBOSIS IN 1769 POST THR CASES
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Glueck, C. J., primary, Salvati, E. A., additional, Della Valle, A. G., additional, Westrich, G., additional, Rana, A. J., additional, Specht, L., additional, Weksler, B. B., additional, and Wang, P., additional
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- 2005
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17. Prophylaxis of deep venous thrombosis in total hip arthroplasty
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Böttner, F., primary, Sculco, T. P., additional, Sharrock, N. E., additional, Westrich, G. H., additional, and Steinbeck, J., additional
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- 2001
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18. Author’s reply
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WESTRICH, G. H., primary
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- 2001
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19. IL-18 is a primary mediator of inflammation associated with DSS-induced colitis: Blocking IL-18 prevents intestinal damage
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SIVAKUMAR, P, primary, WESTRICH, G, additional, KANALY, S, additional, SIMS, J, additional, DERRY, J, additional, and VINEY, J, additional
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- 2001
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20. Resection specimen analysis of proximal tibial anatomy based on 100 total knee arthroplasty specimens
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WESTRICH, G, primary, HAAS, S, additional, INSALL, J, additional, and FRACHIE, A, additional
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- 1995
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21. Anterior iliac crest bone graft harvesting using the corticocancellous reamer system.
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Westrich, Geoffrey H., Geller, David S., O'malley, Martin J., Deland, Jonathan T., Helfet, David L., Westrich, G H, Geller, D S, O'Malley, M J, Deland, J T, and Helfet, D L
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- 2001
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22. Analgesia after total knee replacement: local infiltration versusepidural combined with a femoral nerve blockade
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YaDeau, J. T., Goytizolo, E. A., Padgett, D. E., Liu, S. S., Mayman, D. J., Ranawat, A. S., Rade, M. C., and Westrich, G. H.
- Abstract
In a randomised controlled pragmatic trial we investigated whether local infiltration analgesia would result in earlier readiness for discharge from hospital after total knee replacement (TKR) than patient-controlled epidural analgesia (PCEA) plus femoral nerve block. A total of 45 patients with a mean age of 65 years (49 to 81) received a local infiltration with a peri-articular injection of bupivacaine, morphine and methylprednisolone, as well as adjuvant analgesics. In 45 PCEA+femoral nerve blockade patients with a mean age of 67 years (50 to 84), analgesia included a bupivacaine nerve block, bupivacaine/hydromorphone PCEA, and adjuvant analgesics. The mean time until ready for discharge was 3.2 days (1 to 14) in the local infiltration group and 3.2 days (1.8 to 7.0) in the PCEA+femoral nerve blockade group. The mean pain scores for patients receiving local infiltration were higher when walking (p = 0.0084), but there were no statistically significant differences at rest. The mean opioid consumption was higher in those receiving local infiltration.The choice between these two analgesic pathways should not be made on the basis of time to discharge after surgery. Most secondary outcomes were similar, but PCEA+femoral nerve blockade patients had lower pain scores when walking and during continuous passive movement. If PCEA+femoral nerve blockade is not readily available, local infiltration provides similar length of stay and similar pain scores at rest following TKR. Cite this article: Bone Joint J2013;95-B:629–35.
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- 2013
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23. Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage.
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V, Sivakumar P, M, Westrich G, S, Kanaly, K, Garka, L, Born T, J, Derry J M, and L, Viney J
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BACKGROUND AND AIMS: Persistent inflammation observed in inflammatory bowel disease may be the consequence of an increased or aberrant immune response to normal gut constituents or an overall immune dysregulation and imbalance. Cytokines play an important role in immune regulation and interleukin 18 (IL-18) is one such cytokine that has emerged as being instrumental in driving CD4+ T cell responses towards a Th1-type. IL-18 can also directly mediate inflammation, moderate interleukin 1 activity, and can act on cell types other than T cells. It has been reported recently that IL-18 mRNA and protein are upregulated in gut tissue from IBD patients. The aim of this study was to understand more about the role of IL-18 in contributing to the pathology of IBD and to assess whether blocking IL-18 activity may be of therapeutic benefit as a treatment regimen for IBD. METHODS: Mice with dextran sulphate sodium (DSS) induced colitis were treated with recombinant IL-18 binding protein (IL-18bp.Fc), a soluble protein that blocks IL-18 bioactivity. Histopathological analysis was performed and RNA from the large intestine was analysed using the RNase protection assay and gene arrays. RESULTS: IL-18 RNA levels increased very early in the colon during DSS colitis. Treatment of mice with IL-18bp.Fc inhibited IBD associated weight loss and significantly inhibited the intestinal inflammation induced by DSS. IL-18bp.Fc treatment also attenuated mRNA upregulation of multiple proinflammatory cytokine genes, chemokine genes, and matrix metalloprotease genes in the large intestine that are commonly elevated during IBD. CONCLUSIONS: IL-18bp treatment attenuated inflammation during DSS induced colitis in mice. Neutralising IL-18 activity may therefore be of benefit for ameliorating the inflammation associated with human intestinal diseases.
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- 2002
24. Symptomatic labral tear post femoral shaft fracture: case report.
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Watson D, Walcott-Sapp S, and Westrich G
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- 2007
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25. Current analysis of tibial coverage provided by total knee arthroplasty systems
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Westrich, G. H., Agulnick, M. A., Laskin, R. S., Haas, S. B., and Sculco, T. P.
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- 1997
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26. Current analysis of tibial coverage in total knee arthroplasty
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Westrich, G. H., Agulnick, M. A., Laskin, R. S., Haas, S. B., and Sculco, T. P.
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- 1997
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27. Primary total hip arthroplasty for displaced femoral neck fracture.
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Watson D, Bostrom M, Salvati E, Walcott-Sapp S, and Westrich G
- Abstract
Fracture of the femoral neck is a common injury, especially in the elderly. Currently, approximately $8.7 billion is spent treating 250,000 femoral neck fractures per year, which indicates that the 500,000 projected to occur annually by 2040 will have a staggering economic impact. The optimal treatment for displaced femoral neck fractures in healthy elderly patients has been controversial. Recent literature supports total hip arthroplasty (THA) as the preferred method, citing equivalent mortality, reduced complication rate, and better functional scores than both fracture reduction and fixation and hemiarthroplasty. The fixation group, which was initially less expensive, had a reoperation rate of 39%, while the arthroplasty group's rate was only 9%.Total hip arthroplasty for displaced femoral neck fracture has potential advantages over open reduction and internal fixation and hemiarthroplasty. Thirty-seven patients who underwent THA for displaced femoral neck fractures between June 1993 and June 2005 were evaluated. The exact head/neck ratios were calculated by the prosthesis manufacturers. The major complication rate was 16.1% (6 of 37) with 5 dislocations (all with surgery prior to 2002) and one nonfatal myocardial infarction. One- and 2-year mortality was 2.7% (1 of 37) and 8.1% (3 of 37), respectively. A smaller head/neck ratio (P=.002) in patients who dislocated was observed. The optimal head/neck ratio was >/= 2.13. Total hip arthroplasty for displaced femoral neck fracture allows patients to return to most preinjury activities. In order to avoid dislocation, constructs with a larger head/neck ratio should be used. [ABSTRACT FROM AUTHOR]
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- 2008
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28. HERITABLE THROMBOPHILIA AND DEVELOPMENT OF THROMBOEMBOLIC DISEASE FOLLOWING TOTAL HIP ARTHROPLASTY.
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Salvati, E. A., Della Valle, Gonzalez A., Westrich, G., Rang, A. J., Specht, L., Weksler, B. B., Wang, P., and Glueck, C. J.
- Published
- 2005
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29. COST-BENEFIT ANALYSIS OF 3 STRATEGIES TO DEAL WITH POST TOTAL HIP REPLACEMENT (THR) PULMONARY EMBOLI-DEEP VENOUS THROMBOSIS IN 1769 POST THR CASES.
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Glueck, C. J., Salvati, E. A., Della Valle, A. G., Westrich, G., Rana, A. J., Specht, L., Weksler, B. B., and Wang, P.
- Published
- 2005
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30. More OR time needed for knee surgery in obese patients.
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Gadinsky, Westrich G. M.
- Published
- 2011
31. Evaluating and Treating Patients With a Recalled Exactech Knee Replacement: A Consensus Approach.
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Boettner F, Westrich G, Sculco PK, Sculco TP, Gausden EB, Chalmers BP, Wright T, and Haralambiev L
- Abstract
Competing Interests: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: FB reports relationships with Smith & Nephew, OrthoDevelopment, and AccuPredict Inc. GW reports relationships with Stryker, Ethicon, and Exactech. PKS declares relationships with Lima Corporate and Zimmer Biomet. TPS declares a relationship with Exactech. EBG reports relationships with BICMD and Zimmer. BPC reports relationships with Smith & Nephew and Ortho Development. TW reports relationships with Lima Corporate, Zimmer Biomet, and Exactech; he holds a patent (US Patent 8870964) that forms the basis of part of the Exactech knee system. LH declares no potential conflicts of interest.
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- 2024
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32. Redo Ileocolic Resection for Crohn's Disease, Does It Palliate the Patients as Good as the Primary Resection?
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Hazzan D, Westrich G, and Segev L
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- Humans, Female, Retrospective Studies, Male, Adult, Middle Aged, Postoperative Complications epidemiology, Length of Stay statistics & numerical data, Colon surgery, Treatment Outcome, Young Adult, Operative Time, Crohn Disease surgery, Reoperation statistics & numerical data, Ileum surgery, Colectomy methods
- Abstract
Objective: We questioned how redo ileocolic resection (R-ICR) in Crohn's disease (CD) alleviates patients in the long-term compared with primary resection. Methods: A single-center retrospective analysis of patients who underwent an elective ICR without diversion between the years 2010-2022. The cohort was divided into two groups, namely, R-ICR and primary ileocolic resection (P-ICR). Results: The study included 181 patients, of which 30 patients are in the R-ICR group (mean age 42.3 years) and 151 patients in the P-ICR group (mean age 32.6 years). The R-ICR patients underwent an open approach (76.7% versus 25.2% among the P-ICR, p < .001), had significantly longer operations (mean 200.9 minutes versus 157.2 minutes, respectively, P = .002), and had higher estimated blood loss (mean 350 mL versus 267.4 mL, P = .043). The groups were similar in overall postoperative morbidity, severe postoperative complications (10% versus 13.2%, P = .762), and median length of hospital stay (12.1 days versus 7.4 days, P = .214). After a median follow-up of 64.2 months, there were no significant differences between the groups in terms of endoscopic recurrence (43.3% versus 60.9% in the P-ICR group, P = .104) or in clinical recurrence (43.3% versus 55.6%, respectively, P = .216), but the R-ICR had a significant higher rate of surgical recurrences (23.3% versus 5.3%, respectively, P = .004). Conclusion: R-ICR for CD is a significantly more challenging operation than the primary resection, and patients undergoing a R-ICR are more susceptible to a future surgical intervention than those having P-ICR.
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- 2024
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33. What Is the Role of a Periarticular Injection for Knee Arthroplasty Patients Receiving a Multimodal Analgesia Regimen Incorporating Adductor Canal and Infiltration Between the Popliteal Artery and Capsule of the Knee Blocks? A Randomized Blinded Placebo-Controlled Noninferiority Trial.
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YaDeau JT, Cushner FD, Westrich G, Lauzadis J, Kahn RL, Lin Y, Goytizolo EA, Mayman DJ, Jules-Elysee KM, Gbaje E, and Padgett DE
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- Humans, Male, Female, Aged, Middle Aged, Injections, Intra-Articular, Pain Measurement, Treatment Outcome, Double-Blind Method, Knee Joint surgery, Knee Joint physiopathology, Analgesia methods, Arthroplasty, Replacement, Knee adverse effects, Pain, Postoperative drug therapy, Pain, Postoperative prevention & control, Pain, Postoperative diagnosis, Pain, Postoperative etiology, Nerve Block methods, Popliteal Artery surgery, Anesthetics, Local administration & dosage
- Abstract
Background: Optimal analgesic protocols for total knee arthroplasty (TKA) patients remain controversial. Multimodal analgesia is advocated, often including peripheral nerve blocks and/or periarticular injections (PAIs). If 2 blocks (adductor canal block [ACB] plus infiltration between the popliteal artery and capsule of the knee [IPACK]) are used, also performing PAI may not be necessary. This noninferiority trial hypothesized that TKA patients with ACB + IPACK + saline PAI (sham infiltration) would have pain scores that were no worse than those of patients with ACB + IPACK + active PAI with local anesthetic., Methods: A multimodal analgesic protocol of spinal anesthesia, ACB and IPACK blocks, intraoperative ketamine and ketorolac, postoperative ketorolac followed by meloxicam, acetaminophen, duloxetine, and oral opioids was used. Patients undergoing primary unilateral TKA were randomized to receive either active PAI or control PAI. The active PAI included a deep injection, performed before cementation, of bupivacaine 0.25% with epinephrine, 30 mL; morphine; methylprednisolone; cefazolin; with normal saline to bring total volume to 64 mL. A superficial injection of 20 mL bupivacaine, 0.25%, was administered before closure. Control injections were normal saline injected with the same injection technique and volumes. The primary outcome was numeric rating scale pain with ambulation on postoperative day 1. A noninferiority margin of 1.0 was used., Results: Ninety-four patients were randomized. NRS pain with ambulation at POD1 in the ACB + IPACK + saline PAI group was not found to be noninferior to that of the ACB + IPACK + active PAI group (difference = 0.3, 95% confidence interval [CI], [-0.9 to 1.5], P = .120). Pain scores at rest did not differ significantly among groups. No significant difference was observed in opioid consumption between groups. Cumulative oral morphine equivalents through postoperative day 2 were 89 ± 40 mg (mean ± standard deviation), saline PAI, vs 73 ± 52, active PAI, P = .1. No significant differences were observed for worst pain, fraction of time in severe pain, pain interference, side-effects (nausea, drowsiness, itching, dizziness), quality of recovery, satisfaction, length of stay, chronic pain, and orthopedic outcomes., Conclusions: For TKA patients given a comprehensive analgesic protocol, use of saline PAI did not demonstrate noninferiority compared to active PAI. Neither the primary nor any secondary outcomes demonstrated superiority for active PAI, however. As we cannot claim either technique to be better or worse, there remains flexibility for use of either technique., Competing Interests: Conflicts of Interest: See Disclosures at the end of the article., (Copyright © 2024 International Anesthesia Research Society.)
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- 2024
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34. Cementless Versus Cemented Total Knee Arthroplasty of the Same Design: Shorter Operative Times and Minimal Differences in Early Outcomes.
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Puri S, Alpaugh K, Chiu YF, Ast MP, Jerabek S, Westrich G, and Chalmers B
- Abstract
Introduction: Modern primary cementless total knee arthroplasty (TKA) is increasingly popular, but there is limited evidence on its benefits, early complications, and failures. Purpose : We sought to evaluate operative time, early survivorship, and outcomes of cementless versus cemented TKA of the same design. Methods : As part of this single-center, multisurgeon, retrospective cohort study, we reviewed 598 primary, unilateral TKAs (170 cementless, 428 cemented) of the same design from 2016 to 2018. The cementless cohort was younger (63 vs 67 years) and had more cruciate-retaining implants (17% vs 12%) compared with the cemented cohort. We compared operative time, length of stay, and complications. Survivorship curves were generated via the Kaplan-Meier method. Results : Patients with cementless TKA (using the Triathlon implant, Stryker) had a 24% reduction in operative time (83 vs 109 minutes) but similar length of stay compared with those with cemented TKA (57 vs 61 hours). Cementless TKA had a higher rate of postoperative manipulation for stiffness compared with cemented TKA (8% vs 3%), but there were notable demographic differences between the cohorts. Despite 2 cases (1%) of early cementless tibial aseptic loosening requiring component revision compared with none in the cemented cohort, there was no difference in revision-free survivorship at 2 years (96% and 98%, respectively). Conclusion : This retrospective cohort study found that cementless TKA had a 24% reduction in operative time compared with cemented TKA and similar short-term survivorship. There was a slightly higher rate of aseptic revision and manipulation in the cementless cohort. Further study is warranted on the long-term durability of cemented and cementless TKAs to determine if cementless fixation proves more durable in the midterm to long term., Competing Interests: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Michael P. Ast, MD, declares relationships with American Academy of Orthopedic Surgeons, American Association of Hip and Knee Surgeons, Becton Dickson, Bioventus, Conformis, Convatec, ConveyMED, Eastern Orthopaedic Association, Foundation for Physician Advancement, HS2, Journal of Arthroplasty, Journal of Orthopaedic Innovation and Experience, OrthAlign, Ospitek, Osso VR, Parvizi Surgical Innovations, Smith & Nephew, Stryker, and Surgical Care Affiliates. Seth Jerabek, MD, declares relationships with Imagen Technologies, Stryker, and Wolters Kluwer Health. Geoffrey Westrich, MD, declares relationships with Eastern Orthopedic Association, Ethicon, Exactech, Knee Society, and Stryker. The other authors declare no potential conflicts of interest., (© The Author(s) 2023.)
- Published
- 2024
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35. Increased risk for incisional hernia following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy.
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Ben-Yaacov A, Laks S, Zoabi G, Kirshenboim Z, Goldenshlger A, Hazzan D, Westrich G, Owda Y, Segev L, Nissan A, and Goldenshluger M
- Subjects
- Humans, Hyperthermic Intraperitoneal Chemotherapy, Cytoreduction Surgical Procedures adverse effects, Cytoreduction Surgical Procedures methods, Retrospective Studies, Combined Modality Therapy, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Survival Rate, Incisional Hernia epidemiology, Incisional Hernia etiology, Peritoneal Neoplasms therapy, Hyperthermia, Induced adverse effects, Hyperthermia, Induced methods
- Abstract
Introduction: The incidence of incisional hernias (IH) after midline laparotomy varies from 11% to 20%. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is potentially prone to hernias because a Xiphoid to pubis laparotomy incision performed on patients who have undergone previous abdominal surgeries with the addition of chemotherapy and its related adverse effects., Methods: We performed a retrospective analysis on a prospectively maintained single institution database from March 2015 to July 2020. The inclusion criteria were patients who underwent CRS-HIPEC and had at least 6 months postoperative follow-up with post-operative cross-sectional imaging study., Results: Two hundred and one patients were included in the study. All patients underwent CRS-HIPEC with resection of previous scar and umbilectomy. Fifty-four patients were diagnosed with IH (26.9%). The major risk factors for IH in multivariate analysis were higher American society of Anesthesiologists score (ASA) (OR 3.9, P = 0.012), increasing age (OR 1.06, P = 0.004) and increasing BMI (OR 1.1, P = 0.006). Most of the hernia sites were median (n = 43, 79.6%). Eleven (20.4%) patients had lateral hernias due to stoma incisions or drain sites. Most of the median hernias were at the level of the resected umbilicus 58.9% (n = 23). Five (9.3%) of the patients with IH necessitated an urgent surgical repair., Conclusion: We have demonstrated that more than a quarter of the patients after CRS-HIPEC suffer from IH and up to 10% of them may require surgical intervention. More research is needed to find the appropriate intraoperative interventions to minimize this sequela., (© 2023 The Authors. ANZ Journal of Surgery published by John Wiley & Sons Australia, Ltd on behalf of Royal Australasian College of Surgeons.)
- Published
- 2023
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36. Mid-term survivorship of primary total knee arthroplasty with a specific implant.
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Gausden EB, Puri S, Chiu YF, Figgie MP, Sculco TP, Westrich G, Sculco PK, and Chalmers BP
- Subjects
- Humans, Retrospective Studies, Survivorship, Polyethylene, Arthroplasty, Replacement, Knee, Osteolysis
- Abstract
The purpose of this study was to assess mid-term survivorship following primary total knee arthroplasty (TKA) with Optetrak Logic components and identify the most common revision indications at a single institution. We identified a retrospective cohort of 7,941 Optetrak primary TKAs performed from January 2010 to December 2018. We reviewed the intraoperative findings of 369 TKAs that required revision TKA from January 2010 to December 2021 and the details of the revision implants used. Kaplan-Meier analysis was used to determine survivorship. Cox regression analysis was used to examine the impact of patient variables and year of implantation on survival time. The estimated survivorship free of all-cause revision was 98% (95% confidence interval (CI) 97% to 98%), 95% (95% CI 95% to 96%), and 86% (95% CI 83% to 88%) at two, five, and ten years, respectively. In 209/369 revisions there was a consistent constellation of findings with varying severity that included polyethylene wear and associated synovitis, osteolysis, and component loosening. This failure mode, which we refer to as aseptic mechanical failure, was the most common revision indication. The mean time from primary TKA to revision for aseptic mechanical failure was five years (5 months to 11 years). In this series of nearly 8,000 primary TKAs performed with a specific implant, we identified a lower-than-expected mid-term survivorship and a high number of revisions with a unique presentation. This study, along with the recent recall of the implant, confirms the need for frequent monitoring of patients with Optetrak TKAs given the incidence of polyethylene failure, osteolysis, and component loosening., Competing Interests: M. P. Figgie reports royalties and consulting fees from Lima and Wishbone, and patents and leadership or fiduciary roles for Wishbone, and stock or stock options in Wishbone and HS2, all unrelated to this study. E. Gausden reports consulting fees from Zimmer Biomet and Depuy, unrelated to this study. P. K. Sculco reports royalties from Lima, consulting fees from Zimmer Biomet, DePuy, and Lima, and stock or stock options in Intellijoint Surgical, all unrelated to this study. T. P. Sculco reports royalties from Exatech, support for attending meetings and/or travel from HSS, all unrelated to this study. T. P. Sculco is also President of OREF. G. Weststrich reports royalties from Stryker, consulting fees and speaker payments from Stryker and Ethicon, and a leadership or fiduciary role for the Eastern Orthopedic Association, all of which are unrelated to this study., (© 2023 The British Editorial Society of Bone & Joint Surgery.)
- Published
- 2023
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37. No Change in Serum Metal Ions Levels After Primary Total Hip Replacement With an Additively Manufactured Dual Mobility Acetabular Construct.
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Alpaugh K, Mishu M, and Westrich G
- Abstract
Background: Modular junctions of mixed metals have been associated with fretting and corrosion, and in extreme circumstances, adverse local tissue reactions. Since modular dual mobility (MDM) hip constructs involve a titanium shell with a modular cobalt-chromium liner, the aim of this study was to evaluate serum metal ions at minimum 1 year following total hip arthroplasty (THA) in a cohort of patients with these types of implants., Methods: A single surgeon enrolled 30 patients in a prospective study in which all patients were evaluated preoperatively with serum cobalt, chromium, and titanium metal ion levels. Patients underwent primary THA with an additively manufactured titanium acetabular shell, MDM cobalt-chromium liner, titanium cementless stem, and ceramic head. A "Four Quadrant Test" was used to ensure proper liner seating intraoperatively. At minimum 1 year following surgery, clinical and radiographic evaluation was conducted, and repeat metal ion levels were collected. Patient-reported outcome measures were collected preoperatively and postoperatively., Results: Twenty-five patients completed 1-year follow-up. All patients had normal metal ion levels for cobalt (<1 μg/L), chromium (<5 μg/L), and titanium (sensitivity test) preoperatively and postoperatively. Patient-reported outcome measures improved significantly after primary THA: Veterans RAND-12 Physical Component Score (31.05 to 45.02, P < .001), Visual Analogue Scale Pain score (70.68 to 7.77, P < .001), Hip Disability and Osteoarthritis Outcomes Score, Joint Replacement (51.99 to 86.97, P < .001)., Conclusions: No significant elevation was detected in serum metal ion levels 16 months following THA using an additively manufactured titanium acetabular shell, a cobalt-chromium MDM liner, and titanium stem with a ceramic head., (© 2022 The Authors.)
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- 2022
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38. Differences in Patient-Reported Outcome Measures Between Primary and Revision Total Hip Arthroplasty: Realistic Patient Expectations for Patients With Low Baseline Activity.
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Dubin J and Westrich G
- Subjects
- Cohort Studies, Humans, Motivation, Pain, Patient Reported Outcome Measures, Reoperation, Treatment Outcome, Arthroplasty, Replacement, Hip
- Abstract
Primary total hip arthroplasty (pTHA) and revision total hip arthroplasty (rTHA) are not often compared in terms of patient-reported outcome measures (PROMs). However, surgeons and patients need to better understand the differences in PROMs between primary and revision surgery to set realistic patient expectations and recovery milestones. A matched cohort study of pTHA to rTHA was performed with our arthroplasty database of a single surgeon's experience from 2012 to 2018. There was a significant difference in both pre-operative assessment and change from preoperative to postoperative assessment of the PROMs. Patients undergoing pTHA had higher visual analog scale (VAS) pain scores (67.9 vs 57.9, P =.004). Those undergoing rTHA had higher Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) (57.1 vs 50.1, P =.008) and Veterans RAND 12 Item Health Survey (VR-12) (33.5 vs 33.1, P =.01) scores. However, a significant change was noted in the difference from preoperative to postoperative scores between the pTHA and rTHA groups: Harris Hip Score (HHS) total score (pTHA 30.7 vs rTHA 4.4, P <.001), WOMAC score (pTHA 29.3 vs rTHA 12.2, P <.001), and VAS pain score (pTHA -48.3 vs rTHA -26.5, P <.001) as well as groin pain (pTHA 1.4% vs rTHA 7.1%, P =.02). Further, PROMs after rTHA were inferior to those after pTHA with several outcome instruments, including HHS, WOMAC score, and VAS pain score. In addition, groin pain was significantly greater in the rTHA cohort compared with the pTHA cohort at the latest follow-up. This study allows surgeons and patients to better understand the differences in PROMs to set realistic patient expectations and recovery milestones. [ Orthopedics . 2022;45(4):251-255.].
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- 2022
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39. Effect of Duloxetine on Opioid Use and Pain After Total Knee Arthroplasty: A Triple-Blinded Randomized Controlled Trial.
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YaDeau JT, Mayman DJ, Jules-Elysee KM, Lin Y, Padgett DE, DeMeo DA, Gbaje EC, Goytizolo EA, Kim DH, Sculco TP, Kahn RL, Haskins SC, Brummett CM, Zhong H, and Westrich G
- Subjects
- Analgesia, Patient-Controlled, Analgesics, Opioid, Double-Blind Method, Duloxetine Hydrochloride therapeutic use, Humans, Pain, Postoperative drug therapy, Pain, Postoperative etiology, Arthroplasty, Replacement, Knee adverse effects, Opioid-Related Disorders etiology
- Abstract
Background: Duloxetine, a serotonin-norepinephrine dual reuptake inhibitor, may improve analgesia after total knee arthroplasty (TKA). Previous studies had one primary outcome, did not consistently use multimodal analgesia, and used patient-controlled analgesia devices, potentially delaying discharge. We investigated whether duloxetine would reduce opioid consumption or pain with ambulation., Methods: A total of 160 patients received 60 mg duloxetine or placebo daily, starting from the day of surgery and continuing 14 days postoperatively. Patients received neuraxial anesthesia, peripheral nerve blocks, acetaminophen, nonsteroidal anti-inflammatory drugs, and oral opioids as needed. The dual primary outcomes were Numeric Rating Scale (NRS) scores with movement on postoperative days 1, 2, and 14, and cumulative opioid consumption surgery through postoperative day 14., Results: Duloxetine was noninferior to placebo for both primary outcomes and was superior to placebo for opioid consumption. Opioid consumption (mean ± SD) was 288 ± 226 mg OME [94, 385] vs 432 ± 374 [210, 540] (duloxetine vs placebo) P = .0039. Pain scores on POD14 were 4.2 ± 2.0 vs 4.8 ± 2.2 (duloxetine vs placebo) P = .018. Median satisfaction with pain management was 10 (8, 10) and 8 (7, 10) (duloxetine vs placebo) P = .046. Duloxetine reduced interference by pain with walking, normal work, and sleep., Conclusion: The 29% reduction in opioid use corresponds to 17 fewer pills of oxycodone, 5 mg, and was achieved without increasing pain scores. Considering the ongoing opioid epidemic, duloxetine can be used to reduce opioid usage after knee arthroplasty in selected patients that can be appropriately monitored for potential side effects of the medication., (Copyright © 2022 Elsevier Inc. All rights reserved.)
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- 2022
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40. Temporary new implant spacers increase post-reimplantation total knee prosthesis survival after periprosthetic joint infection.
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Woon CYL, Nguyen J, Kapadia M, Russell CA, Henry M, Miller A, and Westrich G
- Subjects
- Anti-Bacterial Agents therapeutic use, Humans, Knee Joint surgery, Prosthesis Failure, Reoperation, Replantation, Retrospective Studies, Treatment Outcome, Arthroplasty, Replacement, Knee adverse effects, Knee Prosthesis adverse effects, Prosthesis-Related Infections drug therapy, Prosthesis-Related Infections surgery
- Abstract
Purpose: Two-stage exchange arthroplasty is considered the gold standard for treatment of periprosthetic joint infection (PJI) following total knee arthroplasty (TKA). Antibiotic cement spacers can include cement-based spacers (CBS), new components (NEW), and autoclaved components (ACL). The factors that most influence post-reimplantation prosthesis (PRP) survival were determined., Methods: A retrospective database review of patients undergoing two-stage exchange arthroplasty from 2008 to 2014 was performed. There were 85 patients, 25 patients and 30 patients in CBS, NEW and ACL groups, respectively. Patient, disease and surgical characteristics were collected and analyzed. Post-reimplantation prosthesis (PRP) survival was modeled using the Kaplan-Meier method. Cox proportional hazard modeling was then performed to identify risk factors associated with implant failure., Results: Overall PRP survival was 82% in 140 unilateral TKAs. PRP survival between groups was 81%, 96% and 73% within the minimum 2-year follow-up period, respectively. There was a difference in median interval-to-reimplantation between groups (CBS, 72.0 days; NEW, 111.0 days; ACL, 84.0 days, p = 0.003). Adjusting for time-to-reimplantation, NEW spacers demonstrated greater PRP survival compared with ACL spacers (p = 0.044), and a trend towards greater survival compared with CBS spacers (p = 0.086). Excluding early failures (< 90 days), NEW spacers still demonstrated greater survival than ACL spacers (p = 0.046). Lower volume (≤ 10 within this series) surgeons tended to use more CBS spacers, while higher volume surgeons were comfortable with ACL spacers., Conclusions: There was greater PRP survival with NEW spacers. NEW spacers also demonstrated an increased inter-stage interval, likely because of increased comfort and motion. There were spacer choice differences between low- and high-volume surgeons., Level of Evidence: III., (© 2020. European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA).)
- Published
- 2021
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41. The Accuracy and Clinical Success of Robotic-Assisted Total Knee Arthroplasty.
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Nickel BT, Carroll KM, Pearle AD, Kleeblad LJ, Burger J, Mayman DJ, Westrich G, and Jerabek SA
- Abstract
Background : Robotic-assisted total knee arthroplasty (rTKA) has emerged as a patient-specific customizable tool that enables 3-dimensional preoperative planning, intraoperative adjustment, robotic-assisted bone preparation, and soft-tissue protection. Haptic rTKA may enhance component positioning, but only a few small studies have examined patient satisfaction and clinical outcomes after haptic rTKA. Purpose : In patients who underwent haptic rTKA, we sought to evaluate (1) the discrepancy in alignment between the executed surgical plan and implanted alignment in the coronal and sagittal planes 1 year postoperatively and (2) patient-reported outcomes 2 years postoperatively. Methods : From a prospectively collected database, we reviewed 105 patients who underwent haptic rTKA from August 2016 to May 2017. Two fellowship-trained arthroplasty surgeons independently reviewed hip-to-ankle standing biplanar radiographs to measure overall limb alignment and individual tibial and femoral component alignment relative to the mechanical axis and compared this to the executed surgical plan. Patient-reported outcomes were collected preoperatively and at 2 years postoperatively using the Lower Activity Extremity Score (LEAS), Knee Injury and Osteoarthritis Outcome Score Junior (KOOS Jr.), and Numeric Pain Rating Scale (NPRS). Results : Mean patient age was 62.4 years, and mean body mass index was 30.6 kg/m
2 . Interobserver reliability was significant with a κ of 0.89. Absolute mean deviations in postoperative coronal alignment compared to intraoperative alignment were 0.625° ± 0.70° and 0.45° ± 0.50° for the tibia and femur, respectively. Absolute mean deviations in postoperative tibial sagittal alignment were 0.47° ± 0.76°. Overall mechanical alignment was 0.97° ± 1.79°. Outcomes in LEAS, KOOS Jr., and NPRS changed from 8 to 10, 78 to 88.3, and 8 to 1, respectively. Conclusions : Haptic rTKA demonstrated high reliability and accuracy (less than 1°) of tibial coronal, femoral coronal, and tibial sagittal component alignment postoperatively compared to the surgical plan. Patient-reported outcomes improved, as well. A more rigorous study on long-term outcomes is warranted., Competing Interests: Declaration of Conflicting Interests: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Kaitlin M. Carroll, BS, reports relationships with Canary Medical and Orthalign. Andrew D. Pearle, MD, reports relationships with Stryker, Exactech, Engage, Smith and Nephew, and Zimmer. David J. Mayman, MD, reports relationships with Stryker, Imagen, Insight, Smith and Nephew, and Wishbone. Geoffrey Westrich, MD, reports relationships with Stryker, Exactech, and Mallinckrodt Pharmaceuticals. Seth Jerabek, MD, reports relationships with Stryker and Imagen. Brian Nickel, MD, Laura J. Kleeblad, MD, and Joost Burger, DMed, declare no potential conflicts of interests., (© The Author(s) 2021.)- Published
- 2021
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42. Trends of Utilization and 90-Day Complication Rates for Computer-Assisted Navigation and Robotic Assistance for Total Knee Arthroplasty in the United States From 2010 to 2018.
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Bendich I, Kapadia M, Alpaugh K, Diane A, Vigdorchik J, and Westrich G
- Abstract
Background: Computer-assisted navigation (CAN) and robotic assistance (RA) for total knee arthroplasty (TKA) are gaining in popularity. The purpose of this study is to update the literature on United States technology-assisted TKA trends of national utilization, regional utilization, and 90-day complication rates requiring readmission., Methods: Patients who underwent primary, elective TKA between 2010 and 2018 were retrospectively identified in the PearlDiver All Payer Claims Database (PearlDiver Technologies Inc.). TKAs were classified as conventional, CAN, or RA based on International Classification of Diseases nineth or tenth revision and Current Procedural Technology codes. Annual rates and regional trends of each type of TKA were reported. Ninety-day complications requiring readmission for each group were captured. Multivariable logistic regression was used to identify odds ratios (OR) for all-cause readmission based on TKA modality., Results: Of the 1,307,411 elective TKAs performed from 2010 to 2018, 92.8% were conventional, and 7.7% were technology-assisted (95.2% CAN and 4.9% RA). RA-TKA had the greatest increase in utilization (+2204%). The Western region had the highest utilization of technologies for TKA, while the Midwestern region had the lowest. Ninety-day postoperative complications requiring readmission were highest for conventional TKA and lowest for RA-TKA. RA-TKA (OR 0.68; 97.5% confidence interval 0.56-0.83, P < .001) and CAN-TKA (OR 0.93; 97.5% confidence interval 0.88-0.97, P < .05) had significantly lower odds of all-cause 90-day complications requiring readmission than conventional TKA., Conclusion: Utilization of RA-TKA and CAN-TKA continues to rise across the United States. The use of these technologies is associated with a lower OR of readmission within 90 days postoperatively., (© 2021 The Authors.)
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- 2021
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43. Comparison of Iatrogenic Soft Tissue Trauma in Robotic-Assisted versus Manual Partial Knee Arthroplasty.
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Hampp EL, Scholl L, Faizan A, Sodhi N, Mont MA, and Westrich G
- Subjects
- Biomechanical Phenomena, Humans, Iatrogenic Disease, Knee Joint surgery, Range of Motion, Articular, Anterior Cruciate Ligament Injuries surgery, Arthroplasty, Replacement, Knee adverse effects, Robotic Surgical Procedures adverse effects
- Abstract
Partial knee arthroplasty (PKA) is performed to treat end-stage osteoarthritis in a single compartment. There are minimal data characterizing soft-tissue injuries for PKA with robotic and manual techniques. This cadaver study compared the extent of soft-tissue trauma sustained through robotic-arm assisted PKA (RPKA) and manual PKA (MPKA). Five surgeons prepared 24 cadaveric knees for medial PKA, including six MPKA controls and 18 RPKA assigned into three different workflows: RPKA-LB (six knees) - RPKA with legacy burr; RPKA-NB (six knees) - RPKA with new burr design; and RPKA-NBS (six knees) - RPKA with new burr design and oscillating saw. Two surgeons estimated trauma to the patellar tendon, quadriceps tendon, anterior cruciate ligament (ACL), medial collateral ligament (MCL), medial capsule, posterior capsule, and posterior cruciate ligament (PCLs) using a five-grade system: Grade 1 - complete soft tissue preservation; Grade 2 - ≤25%; Grade 3 - 26 to 50%; Grade 4 - 51 to 75%; and Grade 5 - ≥76% trauma. A total trauma grade was assigned by summing the grades. Kruskal-Wallis statistical tests were used to assess outcomes. When compared to the MPKA group, all RPKA subgroups had lower total trauma grading (p<0.01), lower posterior capsular damage (p<0.01), and less severe ACL damage (p<0.01). The analysis demonstrated no significant difference between the three RPKA workflows. As this study was performed using cadaveric specimens, additional investigations are necessary to determine associations between robotic or manual-assisted technique, observed soft tissue damage, and postoperative clinical outcomes following PKA.
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- 2021
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44. Robotic surgery for colorectal cancer in the Octogenarians.
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Westrich G, Mykoniatis I, Stefan S, Siddiqi N, Ahmed Y, Cross M, Nissan A, and Khan JS
- Subjects
- Aged, 80 and over, Female, Humans, Male, Operative Time, Postoperative Complications, Prospective Studies, Treatment Outcome, Colorectal Neoplasms surgery, Laparoscopy, Robotic Surgical Procedures
- Abstract
Background: We evaluated the short-term outcomes of robotic colorectal cancer surgery in octogenarian patients, focussing on postoperative morbidity and survival., Methods: All patients ≥80 years in a prospective colorectal cancer database undergoing robotic curative colorectal cancer resection were included. Patient demographics, intraoperative findings, postoperative and oncological outcomes were recorded. Patients were further subdivided into two groups named: old (OG 80-85 years) and very old (VOG ≥ 86 years)., Results: Fifty-eight consecutive patients were included (median age, 83 years; male, 53.4%; median BMI, 26.5). Median total operative time was 230 min, median blood loss 20 ml, median length of stay 7 days. Major complications were seen in 12% of patients; and the 90-day mortality rate was 1.7%. Complete R0 resection achieved in 93% of cases, average lymph node harvest was 22. Overall and disease-free survival was 81% and 87.3%, respectively (median follow-up 24.5 months). We noticed a trend towards more advanced lesion staging in the VOG, but only N2 stage was significant (p = 0.03). There was a statistically significant difference in overall survival in favour of the OG (p = 0.024)., Conclusions: Robotic surgery is feasible in octogenarian patients undergoing curative colorectal cancer resection and is associated with good post-operative outcomes and overall survival., (© 2021 John Wiley & Sons Ltd.)
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- 2021
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45. Outcomes of diverting loop ileostomy reversal in the elderly: a case-control study.
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Segev L, Assaf D, Elbaz N, Schtrechman G, Westrich G, Adileh M, Nissan A, and Goitein D
- Subjects
- Aged, Anastomosis, Surgical, Case-Control Studies, Humans, Middle Aged, Postoperative Complications epidemiology, Retrospective Studies, Ileostomy, Surgical Stomas
- Abstract
Background: Although diverting loop ileostomy (DLI) reversal is considered to be a relatively simple procedure, it is not immune from major morbidity. We aimed to compare outcomes of DLI reversal between elderly and non-elderly patients., Methods: Retrospective review of all patients who underwent DLI reversal at a single tertiary medical centre between 2010 and 2020. The elderly group consisted of patients 70 or older compared to a control group of those younger than 70 years., Results: During the study period, 307 patients underwent DLI reversal. Of these, 76 patients were in the elderly group (mean age 75.6) and 231 in the control group (mean age 55.3). The groups were comparable in terms of mean time interval between the creation of the ileostomy and reversal (242 versus 255 days, respectively, P = 0.5), choice between stapled and hand-sewn anastomoses (97.4% stapled anastomosis versus 93.1%, P = 0.086), median post-operative length of stay (5 days in both, P = 0.086), rates of post-operative complications (26.3% versus 26.8%, P = 0.99), severe complications (5.3% versus 6.9%, P = 0.81) and 30-day readmission rates (13.2% versus 10.8%, P = 0.58). Multivariate analysis found the time interval between the creation of the stoma and its reversal to be the only significant risk factor for major post-operative morbidity. Age was not found to be correlated with post-operative morbidity., Conclusion: The outcomes of loop ileostomy reversal in elderly patients are similar to non-elderly patients. Efforts should be made to decrease the time interval between the creation of the stoma and its reversal as this is a significant risk factor for major post-operative morbidity., (© 2021 Royal Australasian College of Surgeons.)
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- 2021
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46. Colorectal Surgery Surveillance: A Novel Method for Composing an Automated Real-time Prospective Registry.
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Rayman S, Benvenisti H, Westrich G, Schtrechman G, Nissan A, and Segev L
- Subjects
- Cost-Benefit Analysis, Female, Humans, Israel, Male, Medical Records, Middle Aged, Quality Improvement, Registries, Colonic Diseases epidemiology, Colonic Diseases surgery, Colorectal Surgery organization & administration, Colorectal Surgery standards, Digestive System Surgical Procedures adverse effects, Digestive System Surgical Procedures methods, Digestive System Surgical Procedures statistics & numerical data, Medical Records Systems, Computerized organization & administration, Postoperative Complications epidemiology
- Abstract
Background: Medical registries have been shown to be an effective way to improve patient care and reduce costs. Constructing such registries entails extraneous effort of either reviewing medical charts or creating tailored case report forms (CRF). While documentation has shifted from handwritten notes into electronic medical records (EMRs), the majority of information is logged as free text, which is difficult to extract., Objectives: To construct a tool within the EMR to document patient-related data as codified variables to automatically create a prospective database for all patients undergoing colorectal surgery., Methods: The hospital's EMR was re-designed to include codified variables within the operative report and patient notes that documented pre-operative history, operative details, postoperative complications, and pathology reports. The EMR was programmed to capture all existing data of interest with manual completion of un-coded variables., Results: During a 6-month pilot study, 130 patients underwent colorectal surgery. Of these, 104 (80%) were logged into the registry on the same day of surgery. The median time to log the rest of the 26 cases was 1 day. Forty-two patients had a postoperative complication. The most common cause for severe complications was an anastomotic leak with a cumulative rate of 12.3., Conclusions: Re-designing the EMR to enable prospective documentation of surgical related data is a valid method to create an on-going, real-time database that is recorded instantaneously with minimal additional effort and minimal cost.
- Published
- 2021
47. Transanal total mesorectal excision for rectal cancer: Surgical outcomes and short-term oncological outcomes in a single-institution consecutive series.
- Author
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Shimoni I, Venturero M, Shapiro R, Westrich G, Schtrechman G, Hazzan D, Nissan A, Zippel D, and Segev L
- Abstract
Introduction: Rectal cancer surgery is continuously evolving. Transanal total mesorectal excision (TaTME) is a relatively new surgical approach with possible advantages in comparison to current standard surgical techniques. Several studies in recent years have validated this approach regarding safety and effectiveness. We describe our initial experience with TaTME evaluating surgical parameters, post-operative outcomes and short-term oncological outcomes., Methods: This is a retrospective study reviewing all patients who underwent TaTME in a single institution from May 2015 to April 2018., Results: The cohort included 25 patients with an average age of 60.4 (range: 40-86), of which 13 (52%) patients were male. The average body mass index was 26.1. The overall 30-day morbidity rate was 40%, with 20% (five cases) being severe complications, defined by Clavien-Dindo Grade of 3b or above. There were three major interoperative complications. Four cases (16%) required reoperation during the first 30 post-operative days. The median length of stay was 8 days. The surgery duration was on average 296 min (range: 205-510). Negative resection margins were achieved in all patients. At a median follow-up period of 14 months, there were no local recurrences, and 4 cases (16%) had a distant recurrence., Conclusion: This study describes our initial experience with TaTME, which requires a substantial learning curve to minimise complications and morbidity. Oncological outcomes as expressed by the resection margins, number of lymph nodes harvested and local recurrence rates were all comparable to previously published data., Competing Interests: None
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- 2021
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48. Ileal Perforation in Granulomatosis with Polyangiitis: A Rare Complication.
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Levartovsky A, Gilead R, Sharon A, Pomeranz A, Druyan A, Westrich G, Huber RK, Mayan H, and Shilo N
- Subjects
- Aged, Granulomatosis with Polyangiitis complications, Humans, Intestinal Perforation etiology, Male, Granulomatosis with Polyangiitis diagnosis, Ileum pathology, Intestinal Perforation diagnosis
- Published
- 2021
49. Modern trunnion designs do not affect clinically significant patient-reported outcomes.
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Ihekweazu UN, Lyman S, Chiu YF, Vaynberg I, and Westrich G
- Subjects
- Adult, Cohort Studies, Female, Humans, Male, Middle Aged, Prosthesis Design, Arthroplasty, Replacement, Hip methods, Hip Prosthesis, Patient Reported Outcome Measures, Quality of Life
- Abstract
Introduction: Trunnion geometry is known to vary between hip systems. Trunnionosis and the impact of trunnion design on total hip arthroplasty (THA) survival, has gained attention as a failure mechanism. We sought to report the differences in patient-reported outcome measures (PROMs) between the most commonly utilised modern THA trunnions., Methods: We reviewed primary unilateral THA patients from May 2007 to October 2011. The most frequently used stems were included. LEAS, HOOS subdomains, and SF-12 were obtained pre and post operatively while satisfaction was measured at 2 years after THA. Trunnions were grouped by taper geometry and manufacturer. The 2-year change in PROMs for each trunnion was compared to the pooled 2-year change in HOOS for all other trunnions., Results: 3950 THA patients were studied. 6 trunnion designs were evaluated from 5 manufacturers. The range in differences between the 2-year change in individual PROMs were as follows: HOOS pain (0.6-2.4), HOOS symptoms (0-3.8), HOOS ADL (0.4-4), and HOOS QOL (0.5-3.6). None of the differences in the 2-year change in PROMs reached a minimal clinically important change (MCIC), which we previously determined to be a minimum of 9 points for all HOOS domains., Conclusion: All of the trunnions designs utilised in our study cohort demonstrated excellent clinical results. Small differences were well below the known MCIC; and were not clinically relevant. The findings of this study should prompt further investigations into the long-term impact of trunnion design on clinical patient-reported outcomes.
- Published
- 2020
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50. A matched cohort study between cementless TKA and cemented TKA shows a reduction in tourniquet time and manipulation rate.
- Author
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Dubin JA and Westrich GH
- Abstract
Introduction: Cementless total knee arthroplasty (TKA) is now becoming more acceptable with the advent of newer ongrowth constructs and better initial fixation. It has been proposed that cementless TKA may save OR time and result in a lower incidence of manipulation. This study was designed to assess the difference between cemented and cementless TKA., Methods: Our hospital statistician performed a matched cohort analysis between 127 cementless TKAs and 127 cemented TKRs performed by a single surgeon. Patients were matched on age and BMI. Mean tourniquet time between the cemented and cementless TKAs was assessed as well as the rate of manipulation between these groups. Of note, a tourniquet was routinely used in both the cementless and cemented cohorts to reduce confounding bias., Results: A total of 127 cementless TKAs with a mean age of 60.8 years and mean BMI 32.2 were compared to 127 cemented TKAs with a mean age of 61.5 years and mean BMI of 32.2 at an average follow-up of 2.0 years. There was a statistically significant reduction in tourniquet time in the cementless TKA cohort at 45.7 min compared to the cemented TKA cohort at 54.8 min (p = 0.001). Estimated blood loss was similar in both the cementless (179.5 ml) and cemented (196 ml) cohorts (p = 0.3) and postoperative outcomes, including UCLA score.In addition, the cementless TKA cohort had a manipulation rate of 0% compared to 3.1% for the cemented TKA group (p = 0.044)., Discussion and Conclusion: While cementless and cemented TKA have shown similar PROMs and survivorship, we demonstrated a significant reduction in tourniquet time with cementless TKRs, with similar estimated blood loss, and a lower incidence of manipulation with cementless TKRs in this matched cohort study. The increased cost of a cementless implant may be negated if one considers the cost savings of not using cement, the cost savings of not performing manipulations, and the shorter operative time., Competing Interests: The following 10.13039/501100009033COI are reported: Exactech (royalties, paid consultant, research support), Styker (paid consultant, research support), DJO (paid consultant, research support), Eastern Orthopedic Association (board member)., (© 2020 Professor P K Surendran Memorial Education Foundation. Published by Elsevier B.V. All rights reserved.)
- Published
- 2020
- Full Text
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