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Your search keyword '"Weston, P. S. J."' showing total 14 results
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14 results on '"Weston, P. S. J."'

2. Plasma phospho-tau181 in presymptomatic and symptomatic familial Alzheimer’s disease: a longitudinal cohort study

Author

O’Connor, Antoinette, Karikari, Thomas K., Poole, Teresa, Ashton, Nicholas J., Lantero Rodriguez, Juan, Khatun, Ayesha, Swift, Imogen, Heslegrave, Amanda J., Abel, Emily, Chung, Elisha, Weston, Philip S. J., Pavisic, Ivanna M., Ryan, Natalie S., Barker, Suzie, Rossor, Martin N., Polke, James M., Frost, Chris, Mead, Simon, Blennow, Kaj, Zetterberg, Henrik, and Fox, Nick C.

Published
2021
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6. Cortical tau is associated with microstructural imaging biomarkers of neurite density and dendritic complexity in Alzheimer's disease.

Author

Weston, Philip S. J., Coath, William, Harris, Matthew J., Malone, Ian B., Dickson, John, Aigbirhio, Franklin I., Cash, David M., Zhang, Hui, and Schott, Jonathan M.

Abstract

Introduction: In Alzheimer's disease (AD), hyperphosphorylated tau is closely associated with focal neurodegeneration, but the mechanism remains uncertain. Methods: We quantified cortical microstructure using neurite orientation dispersion and density imaging in 14 individuals with young onset AD. Diffusion tensor imaging measured mean diffusivity (MD). Amyloid beta and tau positron emission tomography were acquired and associations with microstructural measures were assessed. Results: When regional volume was adjusted for, in the medial temporal lobe there was a significant negative association between neurite density and tau (partial R2 = 0.56, p = 0.008) and between orientation dispersion and tau (partial R2 = 0.66, p = 0.002), but not between MD and tau. In a wider cortical composite, there was an association between orientation dispersion and tau (partial R2 = 0.43, p = 0.030), but not between other measures and tau. Discussion: Our findings are consistent with tau causing first dendritic pruning (reducing dispersion/complexity) followed by neuronal loss. Advanced magnetic resonance imaging (MRI) microstructural measures have the potential to provide information relating to underlying tau deposition. [ABSTRACT FROM AUTHOR]

Published
2023
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7. Cerebrospinal fluid in the differential diagnosis of Alzheimer’s disease: clinical utility of an extended panel of biomarkers in a specialist cognitive clinic

Author

Paterson, Ross W., Slattery, Catherine F., Poole, Teresa, Nicholas, Jennifer M., Magdalinou, Nadia K., Toombs, Jamie, Chapman, Miles D., Lunn, Michael P., Heslegrave, Amanda J., Foiani, Martha S, Weston, Philip S. J., Keshavan, Ashvini, Rohrer, Jonathan D., Rossor, Martin N., Warren, Jason D., Mummery, Catherine J., Blennow, Kaj, Fox, Nick C., Zetterberg, Henrik, and Schott, Jonathan M.

Published
2018
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8. Transitioning from cerebrospinal fluid to blood tests to facilitate diagnosis and disease monitoring in Alzheimer's disease

Author

Alawode, D. O. T., primary, Heslegrave, A. J., additional, Ashton, N. J., additional, Karikari, T. K., additional, Simrén, J., additional, Montoliu‐Gaya, L., additional, Pannee, J., additional, O´Connor, A., additional, Weston, P. S. J., additional, Lantero‐Rodriguez, J., additional, Keshavan, A., additional, Snellman, A., additional, Gobom, J., additional, Paterson, R. W., additional, Schott, J. M., additional, Blennow, K., additional, Fox, N. C., additional, and Zetterberg, H., additional

Published
2021
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10. Direct Parametric Reconstruction with Joint Motion Estimation/Correction for Dynamic Brain PET Data

Author

Jiao, J., Bousse, A., Thielemans, K., Burgos, Ninon, Weston, P. S. J., Schott, J. M., Atkinson, D., Arridge, S. R., Hutton, B. F., Markiewicz, P., Ourselin, S., Centre for Medical Image Computing (CMIC), and University College of London [London] (UCL)

Subjects
positron emission tomography, Physics::Medical Physics, phantoms, maximum likelihood estimation, Dynamic PET, medical image processing, biomechanics, diseases, simulated [11C]raclopride data, raw PET photon count data, Biomedical imaging, joint motion estimation-correction, spatially aligned temporal PET data, subject head motion, real clinical [18F]florbetapir data, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, dynamic brain PET data, acquisition time, Kinetic theory, motion correction, parametric images, photon counting, motion-corrected parametric images, time 1 h to 2 h, motion-compensated attenuation correction, quantitative analysis, kinetic parameters, Attenuation, subject motion, Alzheimer's disease, image reconstruction, Dynamics, PET reconstruction, raw photon counts, motion compensation, Zubal brain phantom, Photonics, direct parametric reconstruction, joint direct parametric reconstruction motion correction, kinetic analysis, biological tissues, dynamic positron emission tomography data, distorted tissue-to-voxel mapping, maximum likelihood framework
Abstract

00001; International audience; Direct reconstruction of parametric images from raw photon counts has been shown to improve the quantitative analysis of dynamic positron emission tomography (PET) data. However it suffers from subject motion which is inevitable during the typical acquisition time of 1-2 hours. In this work we propose a framework to jointly estimate subject head motion and reconstruct the motion-corrected parametric images directly from raw PET data, so that the effects of distorted tissue-to-voxel mapping due to subject motion can be reduced in reconstructing the parametric images with motion-compensated attenuation correction and spatially aligned temporal PET data. The proposed approach is formulated within the maximum likelihood framework, and efficient solutions are derived for estimating subject motion and kinetic parameters from raw PET photon count data. Results from evaluations on simulated [11C]raclopride data using the Zubal brain phantom and real clinical [18F]florbetapir data of a patient with Alzheimer's disease show that the proposed joint direct parametric reconstruction motion correction approach can improve the accuracy of quantifying dynamic PET data with large subject motion.

Published
2017

14. Factors Associated With the Onset and Persistence of Post–Lumbar Puncture Headache

Author

Monserrate, Andrés E., Ryman, Davis C., Ma, Shengmei, Xiong, Chengjie, Noble, James M., Ringman, John M., Morris, John C., Danek, Adrian, Müller-Sarnowski, Felix, Clifford, David B., McDade, Eric M., Brooks, William S., Darby, David G., Masters, Colin L., Weston, Philip S. J., Farlow, Martin R., Graff-Radford, Neill R., Salloway, Stephen P., Fagan, Anne M., Oliver, Angela, and Bateman, Randall J.

Abstract

IMPORTANCE: This study assesses factors associated with the most common adverse event following lumbar puncture. OBJECTIVE: To identify factors associated with the risk, onset, and persistence of post–dural puncture headache (PDPH). DESIGN, SETTING, AND PARTICIPANTS: We performed univariate and multivariable analyses of 338 lumbar punctures in the Dominantly Inherited Alzheimer Network observational study using linear mixed models, adjusting for participant-level and family-level random effects. MAIN OUTCOMES AND MEASURES: We directly evaluated associations of 3 post–lumbar puncture outcomes (immediate postprocedural headache, PDPH at 24-hour follow-up, and PDPH receiving a therapeutic blood patch) with participant age and sex, positioning, collection method, needle size, needle insertion site, and cerebrospinal fluid (CSF) volume collected. RESULTS: The incidence of adverse events included 73 immediate postprocedural headaches (21.6%), 59 PDPHs at 24-hour follow-up (17.5%), and 15 PDPHs receiving a therapeutic blood patch (4.4%). Greater volume of CSF collected was associated with increased risk of immediate postprocedural headache, largely owing to a nonlinear increase in risk on collection of volumes above 30 mL (odds ratio, 3.73 for >30 mL and 0.98 for <17 mL). In contrast, collection of higher volumes showed a protective effect in decreasing rates of PDPH at 24-hour follow-up and rates of PDPH receiving a therapeutic blood patch (odds ratio, 0.35 per 10 mL). Although differences in needle size did not reach statistical significance, no participant in the 24G needle group received a therapeutic blood patch compared to 8 of 253 for the larger 22G needles. CONCLUSIONS AND RELEVANCE: Factors that acutely lower CSF pressure (eg, seated positioning or extracting very high volumes of CSF) may be associated with transient post−lumbar puncture headache, without increasing rates of persistent PDPH or therapeutic blood patch. Collection of up to 30 mL of CSF appears to be well tolerated and safe.

Published
2015
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