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1. De mundo et corporibus celestibus : Edition critique et commentaire du livre VIII du De proprietatibus rerum de Barthélemy l’Anglais

Author

Draelants, Isabelle, Frunzeanu, Eduard, Iolanda, Ventura, Institut de recherche et d'histoire des textes (IRHT), Centre National de la Recherche Scientifique (CNRS), Atelier Vincent de Beauvais, Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire d'Histoire des Sciences et de Philosophie - Archives Henri Poincaré (LHSP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Centre de Médiévistique Jean-Schneider, Université Nancy 2-Centre National de la Recherche Scientifique (CNRS)-Université Nancy 2-Centre National de la Recherche Scientifique (CNRS), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL), Westfälische Wilhelms-Universität Münster (WWU), Christel Meier, Baudouin Van den Abeele, Michael Twomey, Iolanda Ventura, Robert Halleux, Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Centre de Médiévistique Jean-Schneider, Université Nancy 2-Centre National de la Recherche Scientifique ( CNRS ), and Westfälische Wilhelms-Universität Münster ( WWU )

Subjects
Medieval astrology, [ SHS.HIST ] Humanities and Social Sciences/History, Barthélemy l'Anglais, Astronomie médiévale, Cosmologie médiévale, Medieval cosmology, [ SHS.HISPHILSO ] Humanities and Social Sciences/History, Philosophy and Sociology of Sciences, De proprietatibus rerum, [SHS]Humanities and Social Sciences, [SHS.HISPHILSO]Humanities and Social Sciences/History, Philosophy and Sociology of Sciences, Bartholomaeus Anglicus, [ SHS.CLASS ] Humanities and Social Sciences/Classical studies, Encyclopédies médiévales, [ SHS ] Humanities and Social Sciences, Medieval astronomy, Astrologie médiévale, [SHS.HIST]Humanities and Social Sciences/History, [SHS.CLASS]Humanities and Social Sciences/Classical studies, Medieval encyclopaedias
Abstract

International audience; Critical edition, historical commentary and thorough identification of the sources (auctoritates) of the Book VIII of Bartholomeus Anglicus’ natural encyclopedia : ‘De mundo et corporibus celestibus’ (cosmology, astrology and astronomy).; Edition critique, commentaire historique et identification approfondie des sources (auctoritates) du livre VIII de l’encyclopédie naturelle de Barthélemy l’Anglais, intitulé De mundo et corporibus celestibus (cosmologie, astrologie, astronomie.

Published
2022

2. A Novel Mechanism of Immune Memory Unveiled at the Invertebrate–Parasite Interface

Author

Joachim Kurtz, Christine Coustau, Yannick Moret, Institut Sophia Agrobiotech (ISA), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Recherche Agronomique (INRA), Institute for Evolution and Biodiversity (IEB), Westfälische Wilhelms-Universität Münster (WWU), Biogéosciences [UMR 6282] [Dijon] (BGS), Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Institut Sophia Agrobiotech [Sophia Antipolis] (ISA), Institut National de la Recherche Agronomique (INRA)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut Sophia Agrobiotech [Sophia Antipolis] ( ISA ), Centre National de la Recherche Scientifique ( CNRS ) -Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Institut National de la Recherche Agronomique ( INRA ), Institute for Evolution and Biodiversity ( IEB ), Westfälische Wilhelms-Universität Münster ( WWU ), Biogéosciences [Dijon] ( BGS ), and Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS )

Subjects
0301 basic medicine, [ SDV.MP.PAR ] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Snail, Immunological memory, 03 medical and health sciences, biology.animal, parasitic diseases, [ SDV.EE.IEO ] Life Sciences [q-bio]/Ecology, environment/Symbiosis, innate, [ SDV.IMM ] Life Sciences [q-bio]/Immunology, Biomphalaria glabrata, Parasite hosting, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Invertebrate, Innate immune system, biology, Mechanism (biology), fungi, biology.organism_classification, Cell biology, defense, 030104 developmental biology, Infectious Diseases, Immunology, [SDV.IMM]Life Sciences [q-bio]/Immunology, Parasitology, Schistosoma mansoni, [SDV.EE.IEO]Life Sciences [q-bio]/Ecology, environment/Symbiosis
Abstract

3 pages; International audience; Pinaud et al. recently provided the first global investigation of the molecular processes underlying innate immune memory in an invertebrate species. They showed that the memory response of the snail Biomphalaria glabrata to Schistosoma mansoni infection is associated with a shift from cellular to humoral mechanisms.

Published
2016

3. Expanding the clinical spectrum of recessive truncating mutations of KLHL7 to a Bohring-Opitz-like phenotype

Author

Axel Bohring, Jean-Baptiste Rivière, Joanna Kennedy, Giampaolo Garani, Margo Whiteford, Stefania Bigoni, Bregje W.M. van Bon, Elisa Ballardini, Laurence Faivre, Emmanuelle Ginglinger, Han G. Brunner, Matt Wherlock, Alexander Hoischen, Ruth Newbury-Ecob, Vincent Meyer, Robert Olaso, Geoff Woodward, Rocio Acuna-Hidalgo, Ange-Line Bruel, Judith St-Onge, Maggie Williams, Julien Thevenon, Christel Thauvin-Robinet, Giulia Parmeggiani, Jean-François Deleuze, Ddd Study, Chris C. Buxton, Alessandra Ferlini, Mark Greenslade, Anne Boland, Equipe GAD (LNC - U1231), Lipides - Nutrition - Cancer [Dijon - U1231] ( LNC ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale ( INSERM ), FHU TRANSLAD, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Department of Reproduction and Growth, UOL of Medical Genetics (University Hospital St Anna, Ferrara), University of Ferrara at St. Anna Hospital, Department of Medical Science, UOL of Medical Genetics (University Hospital St Anna, Ferrara), clinical Genetics Department (University Hospitals Bristol), University Hospitals Bristol, Department of Clinical Genetics (Queen Elizabeth University Hospital, Glasgow), Queen Elizabeth University Hospital (Glasgow), Bristol Genetics Laboratory (Southmead Hospital), Southmead Hospital, Department of Human Genetics (McGill University, Montréal), McGill University, Department of Reproduction and Growth, Neonatal Intensive Care Unit (University Hospital St Anna, Ferrara, Italy), Department of Human Genetics, Radboud university medical center, Nijmegen 6500 HB, The Netherlands, Westfälische Wilhelms-Universität Münster ( WWU ), Centre National de Génotypage ( CNG ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Service de Génétique (CH Mulhouse), Centre Hospitalier Emile Muller [Mulhouse] ( CH E.Muller Mulhouse ), Groupe Hospitalier de Territoire Haute Alsace ( GHTHA ) -Groupe Hospitalier de Territoire Haute Alsace ( GHTHA ), The Wellcome Trust Sanger Institute [Cambridge], Department of Human Genetics (McGill University Health Centre, Montréal), McGill University Health Centre [Montréal], Department of Genetics, 849 Department of Human Genetics, Radboud University Medical Center [Nijmegen], Centre de Génétique, Hôpital Couple Enfant (CHU de Grenoble Alpes), CHU Grenoble, Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, FHU TRANSLAD (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Department of Human Genetics [Montréal], McGill University = Université McGill [Montréal, Canada], Westfälische Wilhelms-Universität Münster (WWU), Centre National de Génotypage (CNG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre Hospitalier Emile Muller [Mulhouse] (CH E.Muller Mulhouse), Groupe Hospitalier de Territoire Haute Alsace (GHTHA)-Groupe Hospitalier de Territoire Haute Alsace (GHTHA), McGill University Health Center [Montreal] (MUHC), Università degli Studi di Ferrara = University of Ferrara (UniFE), Westfälische Wilhelms-Universität Münster = University of Münster (WWU), MUMC+: DA Klinische Genetica (5), Klinische Genetica, and RS: FHML non-thematic output

Subjects
0301 basic medicine, Microcephaly, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], PROTEIN, Socio-culturale, 030105 genetics & heredity, Protein degradation, Biology, Crisponi syndrome, medicine.disease_cause, klhl7, whole exome sequencing, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, medicine, Genetics, Bohring-Opitz like syndrome, Genetics (clinical), Gene, Exome sequencing, LIGASE, Mutation, [SDV.GEN]Life Sciences [q-bio]/Genetics, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], Genetic heterogeneity, Genetic disorder, DOMINANT RETINITIS-PIGMENTOSA, medicine.disease, CANCER, humanities, 3. Good health, BAINBRIDGE-ROPERS SYNDROME, 030104 developmental biology, ONSET, [ SDV.GEN ] Life Sciences [q-bio]/Genetics, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9]
Abstract

Background Bohring-Opitz syndrome (BOS) is a rare genetic disorder characterised by a recognisable craniofacial appearance and a typical 'BOS' posture. BOS is caused by sporadic mutations of ASXL1. However, several typical patients with BOS have no molecular diagnosis, suggesting clinical and genetic heterogeneity.Objectives To expand the phenotypical spectrum of autosomal recessive variants of KLHL7, reported as causing Crisponi syndrome/cold-induced sweating syndrome type 1 (CS/CISS1)-like syndrome.Methods We performed whole-exome sequencing in two families with a suspected recessive mode of inheritance. We used the Matchmaker Exchange initiative to identify additional patients.Results Here, we report six patients with microcephaly, facial dysmorphism, including exophthalmos, nevus flammeus of the glabella and joint contractures with a suspected BOS posture in five out of six patients. We identified autosomal recessive truncating mutations in the KLHL7 gene. KLHL7 encodes a BTB-kelch protein implicated in the cell cycle and in protein degradation by the ubiquitin-proteasome pathway. Recently, biallelic mutations in the KLHL7 gene were reported in four families and associated with CS/CISS1, characterised by clinical features overlapping with our patients.Conclusion We have expanded the clinical spectrum of KLHL7 autosomal recessive variants by describing a syndrome with features overlapping CS/CISS1 and BOS.

Published
2017

4. The diversity of coordination chemistry – A special issue in honor of Prof. Pierre Braunstein

Author

Gerhard Erker, Qiang Xu, Paul R. Raithby, Roger Guilard, Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] ( ICMUB ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Westfälische Wilhelms-Universität Münster ( WWU ), University of Bath [Bath], National Institute of Advanced Industrial Science and Technology ( AIST ), Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] (ICMUB), Université de Bourgogne (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Westfälische Wilhelms-Universität Münster (WWU), and National Institute of Advanced Industrial Science and Technology (AIST)

Subjects
chemistry.chemical_classification, 010405 organic chemistry, Chemistry, media_common.quotation_subject, Library science, 010402 general chemistry, 01 natural sciences, Engineering physics, [ CHIM ] Chemical Sciences, 0104 chemical sciences, Coordination complex, Inorganic Chemistry, Honor, Materials Chemistry, [CHIM]Chemical Sciences, Physical and Theoretical Chemistry, ComputingMilieux_MISCELLANEOUS, Diversity (politics), media_common
Abstract

International audience

Published
2017

5. Standardized Nanomechanical Atomic Force Microscopy Procedure (SNAP) for Measuring Soft and Biological Samples

Author

Schillers, Hermann, Rianna, Carmela, Schäpe, Jens, Luque, Tomas, Doschke, Holger, Wälte, Mike, Uriarte, Juan José, Campillo, Noelia, Michanetzis, Georgios P. A., Bobrowska, Justyna, Dumitru, Andra, Herruzo, Elena T., Bovio, Simone, Parot, Pierre, Galluzzi, Massimiliano, Podestà, Alessandro, Puricelli, Luca, Scheuring, Simon, Missirlis, Yannis, Garcia, Ricardo, Odorico, Michael, Teulon, Jean-Marie, Lafont, Frank, Lekka, Malgorzata, Rico, Felix, Rigato, Annafrancesca, Pellequer, Jean-Luc, Oberleithner, Hans, Navajas, Daniel, Radmacher, Manfred, Westfälische Wilhelms-Universität Münster ( WWU ), University of Bremen, University of Barcelona, University of Patras [Patras], Polish Academy of Sciences, Instituto de Ciencia de Materiales de Madrid [Madrid] ( ICMM ), Institut Pasteur de Lille, Réseau International des Instituts Pasteur ( RIIP ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Università degli studi di Milano [Milano], Department Radiation Oncology (Weill Cornell Medicine), Weill Medical College of Cornell University [New York], Institut de Chimie Séparative de Marcoule ( ICSM - UMR 5257 ), Université Montpellier 2 - Sciences et Techniques ( UM2 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Ecole Nationale Supérieure de Chimie de Montpellier ( ENSCM ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de biologie structurale ( IBS - UMR 5075 ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), BIO-AFM-LAB Bio Atomic Force Microscopy Laboratory ( Bio-AFM-Lab ), Aix Marseille Université ( AMU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), ANR-10-EQPX-0004/10-EQPX-0004,Imaginex BioMed,Plateau de microscopie de criblage à haut débit et d'analyse à très haute résolution ( 2010 ), European Project : 340177,EC:FP7:ERC,ERC-2013-ADG,3DNANOMECH ( 2014 ), Westfälische Wilhelms-Universität Münster (WWU), Instituto de Ciencia de Materiales de Madrid (ICMM), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Réseau International des Instituts Pasteur (RIIP), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Università degli Studi di Milano [Milano] (UNIMI), Etude de la Matière en Mode Environnemental (L2ME), Institut de Chimie Séparative de Marcoule (ICSM - UMR 5257), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut de biologie structurale (IBS - UMR 5075 ), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), BIO-AFM-LAB Bio Atomic Force Microscopy Laboratory (Bio-AFM-Lab), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), ANR-10-EQPX-0004,Imaginex BioMed,Plateau de microscopie de criblage à haut débit et d'analyse à très haute résolution(2010), European Project: 340177,EC:FP7:ERC,ERC-2013-ADG,3DNANOMECH(2014), Universitat de Barcelona, Ministerio de Ciencia e Innovación (España), International AFMBioMed Conferences Association, Università degli Studi di Milano, Ministerio de Economía y Competitividad (España), German Research Foundation, European Research Council, Agence Nationale de la Recherche (France), National Science Centre (Poland), Westfälische Wilhelms-Universität Münster = University of Münster (WWU), University of Patras, Polska Akademia Nauk = Polish Academy of Sciences (PAN), Università degli Studi di Milano = University of Milan (UNIMI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)

Subjects
[SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Nanotecnologia, Science, technology, industry, and agriculture, Reproducibility of Results, Biomecànica, Hydrogels, Microscòpia de força atòmica, Microscopy, Atomic Force, Article, Madin Darby Canine Kidney Cells, Atomic force microscopy, Dogs, Elastic Modulus, Medicine, Animals, Nanotechnology, Biomechanics, Stress, Mechanical, [ SDV.BBM.BS ] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM]
Abstract

We present a procedure that allows a reliable determination of the elastic (Young's) modulus of soft samples, including living cells, by atomic force microscopy (AFM). The standardized nanomechanical AFM procedure (SNAP) ensures the precise adjustment of the AFM optical lever system, a prerequisite for all kinds of force spectroscopy methods, to obtain reliable values independent of the instrument, laboratory and operator. Measurements of soft hydrogel samples with a well-defined elastic modulus using different AFMs revealed that the uncertainties in the determination of the deflection sensitivity and subsequently cantilever's spring constant were the main sources of error. SNAP eliminates those errors by calculating the correct deflection sensitivity based on spring constants determined with a vibrometer. The procedure was validated within a large network of European laboratories by measuring the elastic properties of gels and living cells, showing that its application reduces the variability in elastic moduli of hydrogels down to 1%, and increased the consistency of living cells elasticity measurements by a factor of two. The high reproducibility of elasticity measurements provided by SNAP could improve significantly the applicability of cell mechanics as a quantitative marker to discriminate between cell types and conditions., This work was supported by grants to D.N., T.L., N.C., and J.J.U. (Spanish Ministry of Economy and Competitiveness FIS-PI14/00280), M.L. and J.B. (National Science Center NCN DEC-2011/01/M/ST3/00711), H.O. (Deutsche Forschungsgemeinschaft, Koselleck 68/1 and Centre of Excellence, Cells in Motion (CIM), University of Münster, Germany), S.B. and F.L. (ANR-10-EQPX-04-01) and A.D., E.T.H., R.G. (CSD2010-00024, ERC-AdG-340177). A.P. thanks the Dept. of Physics of the University of Milano for financial support under the project “Piano di Sviluppo dell’Ateneo per la Ricerca 2014”, actions: “A. Upgrade of instrumentation”, and “B. Support to young researchers”. We acknowledge the support of the International AFMBioMed Conference Association.

Published
2017

6. Leveraging the EHR4CR platform to support patient inclusion in academic studies: challenges and lessons learned

Author

Justin Doods, Eric Zapletal, Yannick Girardeau, Gilles Chatellier, Bastien Rance, Martin Dugas, Anita Burgun, Christel Daniel, Biomedical informatics and public health department, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherche des Cordeliers (CRC), Université Pierre et Marie Curie - Paris 6 (UPMC)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Westfälische Wilhelms-Universität Münster (WWU), Université Paris Descartes - Paris 5 (UPD5), Unité d’épidémiologie et de recherche clinique [Hôpital européen Georges Pompidou], Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé (LIMICS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris 13 (UP13), HAL-UPMC, Gestionnaire, Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Service d'informatique médicale, Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Sorbonne Paris Nord, APHP, Centre de Recherche des Cordeliers ( CRC ), Université Paris Diderot - Paris 7 ( UPD7 ) -École pratique des hautes études ( EPHE ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Westfälische Wilhelms-Universität Münster ( WWU ), Université Paris Descartes - Paris 5 ( UPD5 ), Hôpital Européen Georges Pompidou [APHP] ( HEGP ), Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé ( LIMICS ), and Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris 13 ( UP13 )

Subjects
Normalization (statistics), Research Report, 020205 medical informatics, Computer science, Epidemiology, Information Storage and Retrieval, Health Informatics, 02 engineering and technology, Reuse, Hospitals, University, 03 medical and health sciences, 0302 clinical medicine, Patient recruitment, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, 0202 electrical engineering, electronic engineering, information engineering, Humans, Electronic health records, 030212 general & internal medicine, lcsh:R5-920, Clinical trial recruitment system, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Patient Selection, Reproducibility of Results, Data science, Data warehouse, 3. Good health, Clinical trial, Research Design, General partnership, Inclusion and exclusion criteria, Feasibility Studies, Completeness (statistics), lcsh:Medicine (General), [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Research Article
Abstract

Background The development of Electronic Health Records (EHRs) in hospitals offers the ability to reuse data from patient care activities for clinical research. EHR4CR is a European public-private partnership aiming to develop a computerized platform that enables the re-use of data collected from EHRs over its network. However, the reproducibility of queries may depend on attributes of the local data. Our objective was 1/ to describe the different steps that were achieved in order to use the EHR4CR platform and 2/ to identify the specific issues that could impact the final performance of the platform. Methods We selected three institutional studies covering various medical domains. The studies included a total of 67 inclusion and exclusion criteria and ran in two University Hospitals. We described the steps required to use the EHR4CR platform for a feasibility study. We also defined metrics to assess each of the steps (including criteria complexity, normalization quality, and data completeness of EHRs). Results We identified 114 distinct medical concepts from a total of 67 eligibility criteria Among the 114 concepts: 23 (20.2%) corresponded to non-structured data (i.e. for which transformation is needed before analysis), 92 (81%) could be mapped to terminologies used in EHR4CR, and 86 (75%) could be mapped to local terminologies. We identified 51 computable criteria following the normalization process. The normalization was considered by experts to be satisfactory or higher for 64.2% (43/67) of the computable criteria. All of the computable criteria could be expressed using the EHR4CR platform. Conclusions We identified a set of issues that could affect the future results of the platform: (a) the normalization of free-text criteria, (b) the translation into computer-friendly criteria and (c) issues related to the execution of the query to clinical data warehouses. We developed and evaluated metrics to better describe the platforms and their result. These metrics could be used for future reports of Clinical Trial Recruitment Support Systems assessment studies, and provide experts and readers with tools to insure the quality of constructed dataset. Electronic supplementary material The online version of this article (doi:10.1186/s12874-017-0299-3) contains supplementary material, which is available to authorized users.

Published
2016

7. Direct P-functionalization of azobenzene by a cationic phosphidozirconocene complex

Author

Gerald Kehr, Pierre Le Gendre, Constantin G. Daniliuc, Adrien T. Normand, Gerhard Erker, Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] ( ICMUB ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Organisch-Chemisches Institut Munster, Westfälische Wilhelms-Universität Münster ( WWU ), Agence Nationale de la Recherche, Deutsche Forschungsgemeinschaft, Conseil Régional de Bourgogne, Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] (ICMUB), Université de Bourgogne (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Westfälische Wilhelms-Universität Münster (WWU)

Subjects
ortho-acylation, Hydrogen, aromatic azo-compounds, chemistry.chemical_element, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, 010402 general chemistry, Bioinformatics, 01 natural sciences, [ CHIM ] Chemical Sciences, Adduct, alcohols, Inorganic Chemistry, chemistry.chemical_compound, c-h functionalization, Polymer chemistry, Nucleophilic substitution, [CHIM]Chemical Sciences, 010405 organic chemistry, Chemistry, Ligand, Cationic polymerization, cinnolinium salts, [ CHIM.INOR ] Chemical Sciences/Inorganic chemistry, Nuclear magnetic resonance spectroscopy, 0104 chemical sciences, 3. Good health, Azobenzene, azoxybenzenes, alpha-oxocarboxylic acids, azoarenes, hydrogen, nucleophilic-substitution, Surface modification
Abstract

International audience; We report that the cationic phosphidozirconocene complex [(eta(5)-C5H5)(2)Zr(PCy2)][CH3B(C6F5)(3)] (II) reacts with azobenzene, resulting in the expedient formation of Zr complex (2) bound to a tridentate PNN ligand. This reaction proceeds by a mechanism of cooperative nucleophilic substitution of hydrogen. The intermediate sigma(H) adduct (1) has been characterized by NMR spectroscopy.

Published
2016

8. Insertion Reactions of Neutral Phosphidozirconocene Complexes as a Convenient Entry into Frustrated Lewis Pair Territory

Author

Birgit Wibbeling, Gerald Kehr, Adrien T. Normand, Constantin G. Daniliuc, Gerhard Erker, Pierre Le Gendre, Organisch-Chemisches Institut Munster, Westfälische Wilhelms-Universität Münster ( WWU ), Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] ( ICMUB ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Agence Nationale de la Recherche, Deutsche Forschungsgemeinschaft (MENOLEP project), Conseil Régional de Bourgogne (PARI CDEA program), Westfälische Wilhelms-Universität Münster (WWU), Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] (ICMUB), and Université de Bourgogne (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Steric effects, Chalcone, Stereochemistry, zirconium, c-h activation, 010402 general chemistry, 01 natural sciences, Medicinal chemistry, [ CHIM ] Chemical Sciences, Catalysis, Frustrated Lewis pair, insertion, chemistry.chemical_compound, Cyclopentadienyl complex, x-ray structures, phosphinidene complexes, Benzophenone, [CHIM]Chemical Sciences, Paraformaldehyde, zr-p bond, zirconocene-phosphido complexes, molecular-structure, 010405 organic chemistry, Ligand, phosphides, Organic Chemistry, Cationic polymerization, crystal-structure, General Chemistry, 0104 chemical sciences, functionalized ligands, bis(trimethylsilyl)phosphido complexes, chemistry, frustrated Lewis pairs, phosphinoaryloxide complexes, ambiphilic ligands
Abstract

International audience; Neutral phosphidozirconocene complexes [Cp2Zr(PR2)Me] (Cp=cyclopentadienyl; 1a: R=cyclohexyl (Cy); 1b: R=mesityl (Mes); 1c: R=tBu) undergo insertion into the Zr-P bond by non-enolisable carbonyl building blocks (O=CRR), such as benzophenone, aldehydes, paraformaldehyde or CO2, to give [Cp2Zr(OCRRPR2)Me] (3-7). Depending on the steric bulk around P, complexes 3-7 react with B(C6F5)(3) to give O-bridged cationic zirconocene dimers that display typical frustrated Lewis pair (FLP)/ambiphilic ligand behaviour. Thus, the reaction of {[Cp2Zr(-OCHPhPCy2)][MeB(C6F5)(3)]}(2) (10a) with chalcone results in 1,4 addition of the Zr+/P FLP, whereas the reaction of {[Cp2Zr(-OCHFcPCy(2))][MeB(C6F5)(3)]}(2) (11a; Fc=(C5H4)CpFe) with [Pd((3)-C3H5)Cl](2) yields the unique Zr-Fe-Pd trimetallic complex 13a, which has been characterised by XRD analysis.

Published
2016

9. Enterocyte Purge and Rapid Recovery Is a Resilience Reaction of the Gut Epithelium to Pore-Forming Toxin Attack

Author

Céline Keime, Kwang-Zin Lee, Stefanie Schirmeier, Dominique Ferrandon, Wennida Miriam Yamba, Caroline Spenlé, Yannick Schwab, Samuel Liégeois, Frédéric Dalle, Matthieu Lestradet, Catherine Socha, Olivier Lefebvre, Richard Bou Aoun, Patricia Simon-Assmann, Antonin Schmitz, Réponse immunitaire et developpement chez les insectes (RIDI - UPR 9002), Université de Strasbourg (UNISTRA)-Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut für Insektenbiotechnologie [Justus-Liebig-Universität Gießen], Justus-Liebig-Universität Gießen (JLU), Institut NeuroMyoGène (INMG), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut für Neuro- und Verhaltensbiologie [Münster], Westfälische Wilhelms-Universität Münster (WWU), Agroécologie [Dijon], Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Immuno-Rhumatologie Moléculaire, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Strasbourg (UNISTRA), Fédération de Médecine Translationnelle de Strasbourg (FMTS), Centre de recherche du médicament Medalis - Drug Discovery Center [LabEx], Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Defymed : Centre Européen Étude du Diabète (CEED), Procédés Alimentaires et Microbiologiques (PAM), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, CNRS, University of Strasbourg, Fondation pour la Recherche Medicale (Equipe FRM), Institut d'Etude Avancee de l'Universite de Strasbourg, Fondation Simone et Cino Del Duca, ANR-11-EQPX-0022/11-EQPX-0022,I2MC,Insectarium pour l'Infectiologie Moléculaire et Cellulaire(2011), Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Louis Pasteur - Strasbourg I, ANR-11-EQPX-0022,I2MC,Insectarium pour l'Infectiologie Moléculaire et Cellulaire(2011), Réponse immunitaire et developpement chez les insectes ( RIDI - UPR 9002 ), Institut de biologie moléculaire et cellulaire ( IBMC ), Université de Strasbourg ( UNISTRA ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Strasbourg ( UNISTRA ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Justus-Liebig-Universität Gießen ( JLU ), Institut NeuroMyoGène ( INMG ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Westfälische Wilhelms-Universität Münster ( WWU ), Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Université de Strasbourg ( UNISTRA ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université de Strasbourg ( UNISTRA ), Fédération de Médecine Translationnelle de Strasbourg ( FMTS ), Institut de génétique et biologie moléculaire et cellulaire ( IGBMC ), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Defymed : Centre Européen Étude du Diabète ( CEED ), Procédés Alimentaires et Microbiologiques ( PAM ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, and ANR-11-EQPX-0022/11-EQPX-0022,I2MC,Insectarium pour l'Infectiologie Moléculaire et Cellulaire ( 2011 )

Subjects
0301 basic medicine, Cytoplasm, Disease tolerance, Survival, Apoptosis, medicine.disease_cause, Oral infection, Hemolysin Proteins, Lipid droplet, [SDV.IDA]Life Sciences [q-bio]/Food engineering, Mitochondrial extrusion, Intestinal Mucosa, Serratia marcescens, Bacterial-infection, Pore-forming toxin, biology, Cell Death, Microvilli, Plasma-membrane, [ SDV.IDA ] Life Sciences [q-bio]/Food engineering, Gut Epithelium, Mitochondria, medicine.anatomical_structure, Drosophila melanogaster, Enterocyte, Virulence Factors, Varroidae, Serratia-marcescens, Bacterial Toxins, Virulence, Microbiology, Serratia Infections, 03 medical and health sciences, Virology, medicine, Animals, Apical cytoplasm, Defense strategy, Drosophila cyclin j, Toxin, biology.organism_classification, Lipid droplets, Disease Models, Animal, Intestinal Diseases, 030104 developmental biology, Enterocytes, Parasitology, Digestive System
Abstract

International audience; Besides digesting nutrients, the gut protects the host against invasion by pathogens. Enterocytes may be subjected to damage by both microbial and host defensive responses, causing their death. Here, we report a rapid epithelial response that alleviates infection stress and protects the enterocytes from the action of microbial virulence factors. Intestinal epithelia exposed to hemolysin, a pore-forming toxin secreted by Serratia marcescens, undergo an evolutionarily conserved process of thinning followed by the recovery of their initial thickness within a few hours. In response to hemolysin attack, Drosophila melanogaster enterocytes extrude most of their apical cytoplasm, including damaged organelles such as mitochondria, yet do not lyse. We identify two secreted peptides, the expression of which requires CyclinJ, that mediate the recovery phase in which enterocytes regain their original shape and volume. Epithelial thinning and recovery constitute a fast and efficient response to intestinal infections, with pore-forming toxins acting as alarm signals.

Published
2016

10. Microbes as engines of ecosystem function: When does community structure enhance predictions of ecosystem processes?: Linking microbes to ecosystem processes

Author

Martin Hartmann, Arnaud Foulquier, Ute Hamer, James I. Prosser, Kazuo Isobe, Jordi Garcia-Pausas, Roberta Pastorelli, Yiping Cao, Nathan Basiliko, Emily B. Graham, Eva S. Lindström, Andreas Richter, Geraldine Nogaro, Ri Qing Yu, Anthony C. Yannarell, Steven D. Siciliano, Marta Goberna, Aurore Kaisermann, Sarah C. Castle, Lachlan J. Ingram, Guy C. J. Abell, Marc Breulmann, Laurent Philippot, Roey Angel, Janne Salminen, Karin Potthast, Bongkeun Song, Joseph E. Knelman, Diana R. Nemergut, Amitava Chatterjee, Ana R. Lopes, Krista Peltoniemi, Sara Hallin, Henri M.P. Siljanen, Marianne Koranda, Helmut Bürgmann, Sokratis Papaspyrou, J. M. Beman, Samiran Banerjee, Ryan J. Newton, Davey L. Jones, Hojeong Kang, Alessandra Lagomarsino, Josep Barba, Lluís Bañeras, Michael S. Strickland, Helen C. Glanville, Andreas Schindlbacher, Olga C. Nunes, Jorge Curiel Yuste, Institute of Arctic and Alpine Research (INSTAAR), University of Colorado [Boulder], Bundesforschungs- und Ausbildungszentrum für Wald, Department of Soil Science, University of Saskatchewan, Helmholtz-Zentrum Geesthacht (GKSS), University of Illinois at Urbana-Champaign [Urbana], University of Illinois System, Sierra Nevada Research Institute, University of California, Flinders University [Adelaide, Australia], Agroécologie [Dijon], Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université Bourgogne Franche-Comté [COMUE] (UBFC), University of Aberdeen, Milieux aquatiques, écologie et pollutions (UR MALY), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Museo Nacional de Ciencias Naturales, Consejo Superior de Investigaciones Cientificas, Bangor University, University of Vienna [Vienna], Häme University of Applied Sciences, University of Wisconsin - Milwaukee, Swiss Federal Institute for Environmental Science and Technology [Dübendorf] (EAWAG), Centre for Carbon, Water and Food, University of Sydney, Westfälische Wilhelms-Universität Münster (WWU), Natural Resources Institute, Technische Universität Dresden (TUD), Universitat de Girona [Girona], Universitat de Girona (UdG), Agroscope, Institute for Sustainability Sciences, CSIRO Agriculture Flagship, Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), University of Texas at Tyler [Tyler], University of Texas at Tyler, Simulation et Traitement de l'information pour l'Exploitation des systèmes de Production (EDF R&D STEP), EDF R&D (EDF R&D), EDF (EDF)-EDF (EDF), Department of Microbiology and Ecosystem Science [Vienna], Montana State University (MSU), Fundació per a la Investigació i la Docència Maria Angustias Giménez [Barcelone] (FIDMAG), FIDMAG Germanes Hospitalaries, Department of Biological Science, Virginia Institute of Marine Science (VIMS), North Dakota State University (NDSU), Faculdade de Engenharia da Universidade do Porto, University of Porto, Center for Coastal and Watershed Studies, United States Geological Survey [Reston] (USGS), Interactions Sol Plante Atmosphère (ISPA), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure des Sciences Agronomiques de Bordeaux-Aquitaine (Bordeaux Sciences Agro), Swedish University of Agricultural Sciences (SLU), Virginia Polytechnic Institute and State University [Blacksburg], Centre Tecnològico Forestal de Catalunya (CTFC), Centre de Recerca Ecològica i Aplicacions Forestals, Universitat Autònoma de Barcelona [Barcelona] (UAB), Yonsei University, The University of Tokyo, Universidad de Cádiz (UCA), Centro di Ricerca per l'Agrobiologia e la Pedologia, Uppsala University, Department of Biology, Laurentian University, Institute of Arctic and Alpine Research ( INSTAAR ), University of Colorado Boulder [Boulder], Helmholtz-Zentrum Geesthacht ( GKSS ), Flinders University, Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université Bourgogne Franche-Comté ( UBFC ), Milieux aquatiques, écologie et pollutions ( UR MALY ), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture ( IRSTEA ), Swiss Federal Institute for Environmental Science and Technology [Dübendorf] ( EAWAG ), Westfälische Wilhelms-Universität Münster ( WWU ), Technische Universität Dresden ( TUD ), Universitat de Girona ( UdG ), Commonwealth Scientific and Industrial Research Organisation [Canberra] ( CSIRO ), Simulation et Traitement de l'information pour l'Exploitation des systèmes de Production ( EDF R&D STEP ), EDF R&D ( EDF R&D ), EDF ( EDF ) -EDF ( EDF ), University of Vienna, Department of Microbiology and Ecosystem Science, Montana State University ( MSU ), Fundació per a la Investigació i la Docència Maria Angustias Giménez [Barcelone] ( FIDMAG ), Virginia Institute of Marine Science, North Dakota State University ( NDSU ), United States Geological Survey [Reston] ( USGS ), Interactions Sol Plante Atmosphère ( ISPA ), Institut National de la Recherche Agronomique ( INRA ) -Ecole Nationale Supérieure des Sciences Agronomiques de Bordeaux-Aquitaine ( Bordeaux Sciences Agro ), Swedish University of Agricultural Sciences ( SLU ), Centre Tecnològico Forestal de Catalunya ( CTFC ), Universitat Autònoma de Barcelona [Barcelona] ( UAB ), Universidad de Cádiz ( UCA ), Faculdade de Engenharia, Biological Sciences, Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Swiss Federal Insitute of Aquatic Science and Technology [Dübendorf] (EAWAG), Technische Universität Dresden = Dresden University of Technology (TU Dresden), Faculdade de Engenharia da Universidade do Porto (FEUP), Universidade do Porto, Interactions Sol Plante Atmosphère (UMR ISPA), Centre de Ciència i Tecnologia Forestal de Catalunya (CTFC), Universitat Autònoma de Barcelona (UAB), and The University of Tokyo (UTokyo)

Subjects
0301 basic medicine, Microbial diversity, lcsh:QR1-502, Ecosystem processes, microbial ecology, lcsh:Microbiology, Environmental data, Microbial ecology, [ SDE ] Environmental Sciences, [ SDV.MP ] Life Sciences [q-bio]/Microbiology and Parasitology, Original Research, ECOLOGIE MICROBIENNE, [SDV.EE]Life Sciences [q-bio]/Ecology, environment, Biomass (ecology), denitrification, Ecology, Respiration, Community structure, 04 agricultural and veterinary sciences, Nitrogen Cycle, Nitrification, Microbial Physiology, nitrification, Statistical modeling, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, [SDE]Environmental Sciences, Denitrification, Functional gene, Microbiology (medical), statistical modeling, Biology, functional gene, Microbiology, Carbon Cycle, [ SDV.EE ] Life Sciences [q-bio]/Ecology, environment, modelling, 03 medical and health sciences, Ecosystem, ecosystem processes, Biogeochemistry, 15. Life on land, MODELISATION, Ecologia microbiana, Mikrobiologi, 030104 developmental biology, Microbial population biology, 13. Climate action, microbial diversity, 040103 agronomy & agriculture, 0401 agriculture, forestry, and fisheries, respiration
Abstract

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms., Microorganisms are vital in mediating the earth's biogeochemical cycles; yet, despite our rapidly increasing ability to explore complex environmental microbial communities, the relationship between microbial community structure and ecosystem processes remains poorly understood. Here, we address a fundamental and unanswered question in microbial ecology: 'When do we need to understand microbial community structure to accurately predict function?' We present a statistical analysis investigating the value of environmental data and microbial community structure independently and in combination for explaining rates of carbon and nitrogen cycling processes within 82 global datasets. Environmental variables were the strongest predictors of process rates but left 44% of variation unexplained on average, suggesting the potential for microbial data to increase model accuracy. Although only 29% of our datasets were significantly improved by adding information on microbial community structure, we observed improvement in models of processes mediated by narrow phylogenetic guilds via functional gene data, and conversely, improvement in models of facultative microbial processes via community diversity metrics. Our results also suggest that microbial diversity can strengthen predictions of respiration rates beyond microbial biomass parameters, as 53% of models were improved by incorporating both sets of predictors compared to 35% by microbial biomass alone. Our analysis represents the first comprehensive analysis of research examining links between microbial community structure and ecosystem function. Taken together, our results indicate that a greater understanding of microbial communities informed by ecological principles may enhance our ability to predict ecosystem process rates relative to assessments based on environmental variables and microbial physiology.

Published
2016

11. Hydrothermalism in the Tyrrhenian Sea: Inorganic and microbial sulfur cycling as revealed by geochemical and multiple sulfur isotope data

Author

Marc Peters, Sven Petersen, Christophe Thomazo, Nicolai-Alexeji Kummer, Harald Strauss, Institut für Geologie und Paläontologie, Westfälische Wilhelms-Universität Münster ( WWU ), Gebäude Ostufer, Leibniz-Institut für Meereswissenschaften ( IFM-GEOMAR ), Lehrstuhl für Hydrogeologie, TU Bergakademie Freiberg, Institut de Physique du Globe de Paris ( IPGP ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -IPG PARIS-Université Paris Diderot - Paris 7 ( UPD7 ) -Université de la Réunion ( UR ) -Centre National de la Recherche Scientifique ( CNRS ), Biogéosciences [Dijon] ( BGS ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), Financial support from the Deutsche Forschungsgemeinschaft (STR 281/26)., Westfälische Wilhelms-Universität Münster (WWU), Leibniz-Institut für Meereswissenschaften (IFM-GEOMAR), Lehrstuhl für Hydrogeologie und Hydrochemie [Freiberg], Technishe Universität Bergakademie Freiberg (TU Bergakademie Freiberg), Institut de Physique du Globe de Paris (IPGP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-IPG PARIS-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS), Biogéosciences [UMR 6282] [Dijon] (BGS), and Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement

Subjects
010506 paleontology, Sulfide, [SDE.MCG]Environmental Sciences/Global Changes, Geochemistry, chemistry.chemical_element, Disproportionation, engineering.material, 010502 geochemistry & geophysics, 01 natural sciences, Hydrothermal circulation, chemistry.chemical_compound, δ34S, [SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistry, Massive sulfide complex, Geochemistry and Petrology, Hydrothermalism, 14. Life underwater, Multiple sulfur isotopes, Sulfate, 0105 earth and related environmental sciences, chemistry.chemical_classification, geography, geography.geographical_feature_category, Sulfur cycling, Geology, [ SDU.STU.GC ] Sciences of the Universe [physics]/Earth Sciences/Geochemistry, Sulfur, [ SDE.MCG ] Environmental Sciences/Global Changes, chemistry, Volcano, 13. Climate action, engineering, Pyrite
Abstract

15 pages; International audience; The Palinuro volcanic complex and the Panarea hydrothermal field, both located in the Tyrrhenian Sea (Italy), are associated with island arc magmatism and characterized by polymetallic sulfide mineralization. Dissolved sulfide concentrations, pH, and Eh measured in porewaters at both sites reveal a variable hydrothermal influence on porewater chemistry. Multiple sulfur isotopic measurements for disseminated sulfides (CRS: chromium reducible sulfur) extracted from sediments at Palinuro yielded a broad range in δ34S range between −29.8 and +10.2‰ and Δ33S values between+0.015 and+0.134‰. In contrast, sediments at Panarea exhibit a much smaller range in δ34SCRS with less negative values between −11.3 and −1.8‰. The sulfur isotope signatures are interpreted to reflect a mixture between hydrothermal and biogenic sulfide, with a more substantial biogenic contribution at Panarea. Multiple sulfur isotope measurements were performed on sulfides and elemental sulfur from drill core material from the Palinuro massive sulfide complex. δ34S andΔ33S values for pyrite between−32.8 and−1.1‰ and between −0.012 to +0.042‰, respectively, as well as for elemental sulfur with δ34S and Δ33S values between −26.7 and −2.1‰ and between +0.035 and +0.109‰, respectively, point to a microbial origin for much of the sulfide and elemental sulfur studied. Moreover, data suggest a coupling of bacterial sulfate reduction, sulfide oxidation and sulfur disproportionation. In addition, δ34S values for barite between +25.0 and +63.6‰ are also in agreement with high microbial turnover of sulfate at Palinuro. Although a magmatic SO2 contribution towards the formation of the Palinuro massive sulfide complex is very likely, the activity of different sulfur utilizing microorganisms played a fundamental role during its formation. Thus, porewater and multiple sulfur isotope data reveal differences in the hydrothermal activity at Palinuro and Panarea drill sites and underline the importance of microbial communities for the origin of massive sulfide mineralizations in the hydrothermal subsurface.

Published
2011

12. 4,5,7-Trisubstituted indeno[1,2-b]indole inhibits CK2 activity in tumor cells equivalent to CX-4945 and shows strong anti-migratory effects

Author

Birus, Robin, El-Awaad, Ehab, Ballentin, Laurens, Alchab, Faten, Aichele, Dagmar, Ettouati, Laurent, Götz, Claudia, Le Borgne, Marc, Jose, Joachim, Universitäts- und Landesbibliothek Münster, Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Assiut University, Molécules bioactives et chimie médicinale (B2MC), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Santé Lyon Est - Louis Léopold Ollier, Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Université de Lyon-Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Saarland University [Saarbrücken], Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Centre Léon Bérard [Lyon], Le Borgne, Marc, Westfälische Wilhelms-Universität Münster (WWU), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)

Subjects
540 Chemistry and allied sciences, Indoles, HPLC‐MS/MS, [SDV.SP.MED] Life Sciences [q-bio]/Pharmaceutical sciences/Medication, QH301-705.5, CK2, [CHIM.THER] Chemical Sciences/Medicinal Chemistry, indeno[1, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, [SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication, Naphthyridines, Biology (General), Casein Kinase II, Research Articles, live‐cell imaging, HPLC-MS/MS, indeno[1,2‐b]indole, Chemistry and allied sciences, live cell imaging, 2-b]indole, [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, ddc:540, indeno[1,2-b]indole, live-cell imaging, pharmacokinetics, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, Phenazines, Research Article
Abstract

Highly pleiotropic and constitutively active protein kinase CK2 is a key target in cancer therapy, but only one small-molecule inhibitor has reached clinical trials—CX-4945. In this study, we present the indeno[1,2-b]indole derivative 5-isopropyl-4-methoxy-7-methyl-5,6,7,8-tetrahydroindeno[1,2-b]indole-9,10-dione (5a-2) that decreased the intracellular CK2 activity in A431, A549, and LNCaP tumor cell lines analogous to CX-4945 (> 75% inhibition at 20 µm) and similarly blocked CK2-specific Akt phosphorylation in LNCaP cells. Cellular uptake analysis demonstrated higher intracellular concentrations of 5a-2 (408.3 nm) compared with CX-4945 (119.3 nm). This finding clarifies the comparable effects of both compounds on the intracellular CK2 activity despite their different inhibitory potency in vitro [IC50 = 25 nm (5a-2) and 3.7 nm (CX-4945)]. Examination of the effects of both CK2 inhibitors on cancer cells using live-cell imaging revealed notable differences. Whereas CX-4945 showed a stronger pro-apoptotic effect on tumor cells, 5a-2 was more effective in inhibiting tumor cell migration. Our results showed that 49% of intracellular CX-4945 was localized in the nuclear fraction, whereas 71% of 5a-2 was detectable in the cytoplasm. The different subcellular distribution, and thus the site of CK2 inhibition, provides a possible explanation for the different cellular effects. Our study indicates that investigating CK2 inhibition-mediated cellular effects in relation to the subcellular sites of CK2 inhibition may help to improve our understanding of the preferential roles of CK2 within different cancer cell compartments., Finanziert über die DEAL-Vereinbarung mit Wiley 2019-2022.

Published
2023

13. The Clouds of Venus – an overview of Venus Express results

Author

Wilson, C. F., Marcq, Emmanuel, Markiewicz, W.J., Montmessin, Franck, Fedorova, A., Wilquet, V., Petrova, E.V., Ignatiev, N.I., Shalygina, O.S., Määttänen, Anni, McGouldrick, K.M., Hashimoto, G.L., Imamura, T., Rossi, Loïc, Luginin, M., Oschlisniok, J., Haus, R., Parkinson, C.D., Titov, D.V., Esposito, L. W., Limaye, Sanjay S., Vandaele, A.-C., Zasova, Liudmila V., Department of Atmospheric, Oceanic and Planetary Physics [Oxford] ( AOPP ), University of Oxford [Oxford], IMPEC - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales ( LATMOS ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Max-Planck-Institut für Sonnensystemforschung ( MPS ), Space Research Institute of the Russian Academy of Sciences ( IKI ), Russian Academy of Sciences [Moscow] ( RAS ), Belgian Institute for Space Aeronomy / Institut d'Aéronomie Spatiale de Belgique ( BIRA-IASB ), Institut für Geophysik und Extraterrestrische Physik [Braunschweig] ( IGEP ), Technische Universität Braunschweig [Braunschweig], Laboratory for Atmospheric and Space Physics [Boulder] ( LASP ), University of Colorado Boulder [Boulder], Okoyama University, Institute of Space and Astronautical Science ( ISAS ), Rhenish Institute for Environmental Research ( RIU ), University of Cologne, Westfälische Wilhelms-Universität Münster ( WWU ), Department of Atmospheric, Oceanic, and Space Sciences [Ann Arbor] ( AOSS ), University of Michigan [Ann Arbor], European Space Research and Technology Centre ( ESTEC ), European Space Agency ( ESA ), Space Science and Engineering Center [Madison] ( SSEC ), University of Wisconsin-Madison [Madison], Department of Atmospheric, Oceanic and Planetary Physics [Oxford] (AOPP), University of Oxford, PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research (MPS), Max-Planck-Gesellschaft, Space Research Institute of the Russian Academy of Sciences (IKI), Russian Academy of Sciences [Moscow] (RAS), Belgian Institute for Space Aeronomy / Institut d'Aéronomie Spatiale de Belgique (BIRA-IASB), Institut für Geophysik und Extraterrestrische Physik [Braunschweig] (IGEP), Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], Laboratory for Atmospheric and Space Physics [Boulder] (LASP), University of Colorado [Boulder], Okayama University, Institute of Space and Astronautical Science (ISAS), Japan Aerospace Exploration Agency [Sagamihara] (JAXA), Rhenish Institute for Environmental Research (RIU), Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Department of Atmospheric, Oceanic, and Space Sciences [Ann Arbor] (AOSS), University of Michigan System-University of Michigan System, European Space Research and Technology Centre (ESTEC), Agence Spatiale Européenne = European Space Agency (ESA), Space Science and Engineering Center [Madison] (SSEC), University of Wisconsin-Madison, Max-Planck-Institut für Sonnensystemforschung (MPS), Westfälische Wilhelms-Universität Münster (WWU), and European Space Agency (ESA)

Subjects
[SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], [ SDU.ASTR.EP ] Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP]
Abstract

International audience; Venus is completely enveloped by clouds. The main cloud layers stretch from altitudes of 48 – 75 km, with additional tenuous hazes found at altitudes 30 – 100 km. Clouds play a crucial role in governing atmospheric circulation, chemistry and climate on all planets, but particularly so on Venus due to the optical thickness of the atmosphere. The European Space Agency’s Venus Express (VEx) satellite has carried out a wealth of observations of Venus clouds since its arrival at Venus in April 2006. Many VEx observations are relevant to cloud science – from imagers and spectrometers to solar, stellar and radio occultation – each covering different altitude ranges, spectral ranges and atmospheric constituents.We have formed an International Team at the International Space Science Institute to bring together scientists from each of the relevant Venus Express investigation teams as well as from previous missions, as well as those developing computational and analytical models of clouds and hazes. The aims of the project are (1) to perform intercomparisons of cloud parameters measured using different techniques, (1) to create self-consistent reference cloud/haze models which capture not only a mean cloud structure but also its main modes of variability; and (2) to bring together modelers and observers, to reach an understanding of clouds and hazes on Venus which matches all observables and is physically consistent.This talk will present an overview of Venus Express cloud observations of all different types, and discuss progress towards a new reference cloud model to be submitted to an update of the Venus International Reference Atmosphere.

Published
2015

14. Efficiency and effectiveness evaluation of an automated multi-country patient count cohort system

Author

Soto Rey, I. (Iñaki), Trinczek, B. (Benjamin), Girardeau, Y. (Yannick), Zapletal, E. (Eric), Ammour, N. (Nadir), Doods, J. (Justin), Dugas, M. (Martin), Fritz, F. (Fleur), Institute of medical informatics, Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Centre de Recherche des Cordeliers (CRC), Université Pierre et Marie Curie - Paris 6 (UPMC)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département d'informatique hospitalière, Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Sanofi-Aventis R&D, SANOFI Recherche, Westfälische Wilhelms-Universität Münster (WWU), Université Paris Diderot - Paris 7 (UPD7)-École pratique des hautes études (EPHE)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Université Pierre et Marie Curie - Paris 6 (UPMC)-École pratique des hautes études (EPHE), Westfälische Wilhelms-Universität Münster ( WWU ), Centre de Recherche des Cordeliers ( CRC ), Université Paris Diderot - Paris 7 ( UPD7 ) -École pratique des hautes études ( EPHE ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Hôpital Européen Georges Pompidou [APHP] ( HEGP ), and Universitäts- und Landesbibliothek Münster

Subjects
Biomedical Research, Internationality, Patient Dropouts, Epidemiology, Patient Selection, Evaluation studies, Cohort Studies, Feasibility studies, Clinical trials as topic, Clinical Protocols, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, Medicine and health, Electronic health records, Multicenter Studies as Topic, ddc:610, Algorithms, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Research Article
Abstract

Background With the increase of clinical trial costs during the last decades, the design of feasibility studies has become an essential process to reduce avoidable and costly protocol amendments. This design includes timelines, targeted sites and budget, together with a list of eligibility criteria that potential participants need to match. The present work was designed to assess the value of obtaining potential study participant counts using an automated patient count cohort system for large multi-country and multi-site trials: the Electronic Health Records for Clinical Research (EHR4CR) system. Methods The evaluation focuses on the accuracy of the patient counts and the time invested to obtain these using the EHR4CR platform compared to the current questionnaire based process. This evaluation will assess the patient counts from ten clinical trials at two different sites. In order to assess the accuracy of the results, the numbers obtained following the two processes need to be compared to a baseline number, the “alloyed” gold standard, which was produced by a manual check of patient records. Results The patient counts obtained using the EHR4CR system were in three evaluated trials more accurate than the ones obtained following the current process whereas in six other trials the current process counts were more accurate. In two of the trials both of the processes had counts within the gold standard’s confidence interval. In terms of efficiency the EHR4CR protocol feasibility system proved to save approximately seven calendar days in the process of obtaining patient counts compared to the current manual process. Conclusions At the current stage, electronic health record data sources need to be enhanced with better structured data so that these can be re-used for research purposes. With this kind of data, systems such as the EHR4CR are able to provide accurate objective patient counts in a more efficient way than the current methods. Additional research using both structured and unstructured data search technology is needed to assess the value of unstructured data and to compare the amount of efforts needed for data preparation. Electronic supplementary material The online version of this article (doi:10.1186/s12874-015-0035-9) contains supplementary material, which is available to authorized users.

Published
2015

15. Joint analysis of BICEP2/Keck array and planck data

Author

K. Ganga, N. Krachmalnicoff, Olivier Doré, W. A. Holmes, M. Lueker, Jose M. Diego, A. Mennella, Nabila Aghanim, Ben Rusholme, F. Elsner, Reijo Keskitalo, C. L. Wong, L. Toffolatti, H. T. Nguyen, J. Jewell, Federico Nati, Valeria Pettorino, Davide Maino, S. J. Benton, Anthony Lasenby, Jacques Delabrouille, Luca Terenzi, C. Combet, F. Piacentini, Simon D. M. White, J. A. Murphy, J. E. Tolan, W. Hovest, Cora Dvorkin, Fabio Finelli, R. Schwarz, M. Frailis, P. B. Lilje, Carlo Baccigalupi, James G. Bartlett, A. Mangilli, Jussi-Pekka Väliviita, F. Pasian, Alessandro Gruppuso, Sunil Golwala, E. Bullock, Guilaine Lagache, François Levrier, E. Hivon, E. Keihänen, M. Rowan-Robinson, G. Patanchon, F. Couchot, L. P. L. Colombo, Dmitry Novikov, Jake Connors, Antony Lewis, M. Tomasi, M. López-Caniego, George Helou, François R. Bouchet, L. A. Wade, Daniela Paoletti, Dipak Munshi, George Efstathiou, Jean-François Cardoso, Ingunn Kathrine Wehus, Marco Bersanelli, J.-F. Sygnet, E. Martínez-González, Etienne Pointecouteau, Charles R. Lawrence, A. D. Turner, J. Aumont, D. Herranz, R. W. Ogburn, J.-M. Lamarre, M. Tucci, Rafael Rebolo, A. C. Weber, Kevin M. Huffenberger, D. Yvon, Roger O'Brient, M. Piat, O. Perdereau, Alain Benoit, Planck Collaborations, Luca Valenziano, Massimiliano Lattanzi, Mark Halpern, Zeeshan Ahmed, S. R. Hildebrandt, E. M. Leitch, A. de Rosa, R. Sudiwala, Mika Juvela, C. Renault, Kate D. Alexander, N. Ponthieu, Alessandro Melchiorri, D. Santos, Hannu Kurki-Suonio, A. Ducout, Stéphane Plaszczynski, Marian Douspis, Daniel J. Mortlock, Fabrizio Villa, Luigi Danese, C. D. Sheehy, Carlo Burigana, G. Hurier, C. Pryke, M. Rossetti, Olivier Forni, L. Montier, M. Tristram, K. L. Thompson, Davide Pietrobon, Lloyd Knox, M.-A. Miville-Deschênes, R. Kneissl, Jörg P. Rachen, Pavel Naselsky, Colin A. Bischoff, R. J. Davis, Locke D. Spencer, Silvia Masi, Andrea Zacchei, W. C. Jones, Bicep, Michael Seiffert, G. Polenta, M. Linden-Vørnle, Duncan Hanson, R. C. Butler, Theodore Kisner, L. Perotto, F. K. Hansen, Bruce Partridge, F. Boulanger, J.-P. Bernard, William T. Reach, F. Noviello, D. L. Harrison, S. Donzelli, A. Renzi, J.-M. Delouis, J.-L. Puget, G. Roudier, Michele Liguori, A. Curto, S. Fliescher, J. F. Macías-Pérez, M. Maris, V. Stolyarov, H. K. Eriksen, Bruno Maffei, E. Franceschi, Benjamin D. Wandelt, Julian Borrill, Jeffrey P. Filippini, R. B. Barreiro, Calvin B. Netterfield, Graca Rocha, Roberta Paladini, T. J. Pearson, P. Vielva, S. Richter, Viktor Hristov, Grant Teply, L. Duband, Giorgio Savini, Michael P. Hobson, F. Pajot, Martin Kunz, A. Catalano, Laura Bonavera, R. A. Sunyaev, A. A. Fraisse, Justus A. Brevik, Mathieu Remazeilles, D. Sutton, Erminia Calabrese, Howard Hui, C. D. Dowell, Anne Lähteenmäki, Ranga-Ram Chary, J. Willmert, Anthony Challinor, M. Sandri, Jon E. Gudmundsson, L. Pagano, Robert A. Watson, L. Mendes, Sabino Matarrese, Victor Buza, A. Karakci, N. Mandolesi, K. G. Megerian, S. Galeotta, J. Knoche, Andrew H. Jaffe, A. Moneti, Simon Prunet, Gene C. Hilton, I. D. Novikov, I. Buder, Philip Lubin, S. A. Kernasovskiy, Peter G. Martin, P. Bielewicz, Jo Dunkley, H. Dole, Subhabrata Mitra, J. A. Tauber, M. Savelainen, L. Vibert, X. Dupac, Brian Keating, Adam Moss, P. de Bernardis, R. D. Davies, Denis Barkats, M. Reinecke, Peter Mason, K. Benabed, Nicola Bartolo, A.-S. Suur-Uski, Martin White, M. Bucher, Douglas Scott, Z. K. Staniszewski, J. R. Bond, E. Gjerløw, Andrea Zonca, Clive Dickinson, Krzysztof M. Gorski, A. Gregorio, H. C. Chiang, P. R. Christensen, E. Battaner, Chao-Lin Kuo, F. Cuttaia, Torsten A. Enßlin, James J. Bock, I. Ristorcelli, Anna Bonaldi, E. Falgarone, Monique Arnaud, Peter Meinhold, Serge Gratton, S. Kefeli, F.-X. Désert, J. González-Nuevo, J. P. Kaufman, Tuhin Ghosh, B. Van Tent, Hans Ulrik Nørgaard-Nielsen, A. J. Banday, Sophie Henrot-Versille, Paolo Natoli, John M Kovac, Kirit Karkare, A. Coulais, Kent D. Irwin, Jose Alberto Rubino-Martin, G. de Zotti, Ki Won Yoon, A. Benoit-Lévy, M. Giard, B. P. Crill, A. Frejsel, Matthew Hasselfield, T. R. Jaffe, M. Migliaccio, Peter A. R. Ade, Abigail G. Vieregg, Randol W. Aikin, R. Leonardi, A. Orlando, S. Galli, G. W. Pratt, Gianluca Morgante, Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Département d'Astrophysique (ex SAP) (DAP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Scuola Internazionale Superiore di Studi Avanzati / International School for Advanced Studies (SISSA / ISAS), Joint ALMA Observatory (JAO), National Radio Astronomy Observatory (NRAO)-European Southern Observatory (ESO), Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), INO-CNR BEC Center and Dipartimento di Fisica, Università degli Studi di Trento (UNITN), Institut d'Astrophysique de Paris (IAP), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Hélium : du fondamental aux applications (HELFA), Institut Néel (NEEL), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Institut für Planetologie [Münster], Westfälische Wilhelms-Universität Münster (WWU), ONERA - The French Aerospace Lab [Châtillon], ONERA-Université Paris Saclay (COmUE), SCANCO Medical AG, Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique (LERMA), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Institute for Climate and Atmospheric Science [Leeds] (ICAS), School of Earth and Environment [Leeds] (SEE), University of Leeds-University of Leeds, Dipartimento di Ingegneria Meccanica-Settore Materiali, Universita degli Studi di Padova, Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Dipartimento di Fisica, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], AUTRES, Laboratoire des Cryoréfrigérateurs et Cryogénie Spatiale (LCCS), Service des Basses Températures (SBT ), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre d'étude spatiale des rayonnements (CESR), Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Laboratoire de Génie Electrique de Grenoble (G2ELab), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Istituto di Astrofisica Spaziale e Fisica cosmica - Bologna (IASF-Bo), Istituto Nazionale di Astrofisica (INAF), Department of Physics and Astronomy [Vancouver], University of British Columbia (UBC), National Center for Atmospheric Research [Boulder] (NCAR), Queens Med Res Inst, Div Pathol, Univ Edinburgh, Infrared Processing and Analysis Center (IPAC), California Institute of Technology (CALTECH), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Max-Planck-Institut für Astronomie (MPIA), Max-Planck-Gesellschaft, International Center for Relativistic Astrophysics (ICRA), Università degli Studi di Roma, School of Physics and Astronomy, University of Manchester [Manchester], Laboratory for Experimental Medicine and Endocrinology, Catholic University of Leuven (LEGENDO), Université Catholique de Louvain = Catholic University of Louvain (UCL), Dipartimento di Fisica, Universita` di Roma Tor Vergata, Università degli Studi di Roma Tor Vergata [Roma], Istituto Nazionale di Fisica Nucleare, Sezione di Padova (INFN, Sezione di Padova), Istituto Nazionale di Fisica Nucleare (INFN), Astrophysics Group, Blackett Laboratory, Imperial College London-Imperial College London, School of Social and Community Medicine [Bristol], University of Bristol [Bristol], Antarctic Research a European Network for Astrophysics (ARENA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire de Physique Théorique d'Orsay [Orsay] (LPT), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), National High Magnetic Field Laboratory (NHMFL), Florida State University [Tallahassee] (FSU), Département de Physique des Particules (ex SPP) (DPP), BICEPS2/Keck Array, Planck, Anne Lähteenmäki Group, Department of Radio Science and Engineering, Aalto-yliopisto, Aalto University, R, P, Aghanim, N, Ahmed, Z, Aikin, R, Alexander, K, Arnaud, M, Aumont, J, Baccigalupi, C, Banday, A, Barkats, D, Barreiro, R, Bartlett, J, Bartolo, N, Battaner, E, Benabed, K, Benoit, A, Benoit Levy, A, Benton, S, Bernard, J, Bersanelli, M, Bielewicz, P, Bischoff, C, Bock, J, Bonaldi, A, Bonavera, L, Bond, J, Borrill, J, Bouchet, F, Boulanger, F, Brevik, J, Bucher, M, Buder, I, Bullock, E, Burigana, C, Butler, R, Buza, V, Calabrese, E, Cardoso, J, Catalano, A, Challinor, A, Chary, R, Chiang, H, Christensen, P, L, ., Combet, C, Connors, J, Couchot, F, Coulais, A, Crill, B, Curto, A, Cuttaia, F, Danese, L, Davies, R, Davis, R, DE BERNARDIS, P, Rosa, A, Zotti, G, Delabrouille, J, Delouis, J, Desert, F, Dickinson, C, Diego, J, Dole, H, Donzelli, S, Dore, O, Douspis, M, Dowell, C, Duband, L, Ducout, A, Dunkley, J, Dupac, X, Dvorkin, C, Efstathiou, G, Elsner, F, Ensslin, T, Eriksen, H, Falgarone, E, Filippini, J, Finelli, F, Fliescher, S, Forni, O, Frailis, M, Fraisse, A, Franceschi, E, Frejsel, A, Galeotta, S, Galli, S, Ganga, K, Ghosh, T, Giard, M, Gjerlow, E, Golwala, S, Gonzalez Nuevo, J, Gorski, K, Gratton, S, Gregorio, A, Gruppuso, A, Gudmundsson, J, Halpern, M, Hansen, F, Hanson, D, Harrison, D, Hasselfield, M, Helou, G, Henrot Versillee, S, Herranz, D, Hildebrandt, S, Hilton, G, Hivon, E, Hobson, M, Holmes, W, Hovest, W, Hristov, V, Huffenberger, K, Hui, H, Hurier, G, Irwin, K, Jaffe, A, Jaffe, T, Jewell, J, Jones, W, Juvela, M, Karakci, A, Karkare, K, Kaufman, J, Keating, B, Kefeli, S, Keihanen, E, Kernasovskiy, S, Keskitalo, R, Kisner, T, Kneissl, R, Knoche, J, Knox, L, Kovac, J, Krachmalnicoff, N, Kunz, M, Kuo, C, Kurki Suonio, H, Lagache, G, Lahteenmaki, A, Lamarre, J, Lasenby, A, Lattanzi, M, Lawrence, C, Leitch, E, Leonardi, R, Levrier, F, Lewis, A, Liguori, M, Lilje, P, Linden Vornle, M, Lopez Caniego, M, Lubin, P, Lueker, M, Macias Perez, J, Maffei, B, Maino, D, Mandolesi, N, Mangilli, A, Maris, M, Martin, P, Martinez Gonzalez, E, Masi, S, Mason, P, Matarrese, S, Megerian, K, Meinhold, P, Melchiorri, A, Mendes, L, Mennella, A, Migliaccio, M, Mitra, S, Miville Deschenes, M, Moneti, A, Montier, L, Morgante, G, Mortlock, D, Moss, A, Munshi, D, Murphy, J, Naselsky, P, Nati, F, Natoli, P, Netterfield, C, Nguyen, H, Norgaard Nielsen, H, Noviello, F, Novikov, D, Novikov, I, O'Brient, R, Ogburn, R, Orlando, A, Pagano, L, Pajot, F, Paladini, R, Paoletti, D, Partridge, B, Pasian, F, Patanchon, G, Pearson, T, Perdereau, O, Perotto, L, Pettorino, V, Piacentini, F, Piat, M, Pietrobon, D, Plaszczynski, S, Pointecouteau, E, Polenta, G, Ponthieu, N, Pratt, G, Prunet, S, Pryke, C, Puget, J, Rachen, J, Reach, W, Rebolo, R, Reinecke, M, Remazeilles, M, Renault, C, Renzi, A, Richter, S, Ristorcelli, I, Rocha, G, Rossetti, M, Roudier, G, Rowan Robinson, M, Rubino Martin, J, Rusholme, B, Sandri, M, Santos, D, Savelainen, M, Savini, G, Schwarz, R, Scott, D, Seiffert, M, Sheehy, C, Spencer, L, Staniszewski, Z, Stolyarov, V, Sudiwala, R, Sunyaev, R, Sutton, D, Suur Uski, A, Sygnet, J, Tauber, J, Teply, G, Terenzi, L, Thompson, K, Toffolatti, L, Tolan, J, Tomasi, M, Tristram, M, Tucci, M, Turner, A, Valenziano, L, Valiviita, J, Tent, B, Vibert, L, Vielva, P, Vieregg, A, Villa, F, Wade, L, Wandelt, B, Watson, R, Weber, A, Wehus, I, White, M, M, S, Willmert, J, Wong, C, Yoon, K, Yvon, D, Zacchei, A, Zonca, A, Bicep, K, Planck, C, Institut d'astrophysique spatiale ( IAS ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Département d'Astrophysique (ex SAP) ( DAP ), Institut de Recherches sur les lois Fondamentales de l'Univers ( IRFU ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Scuola Internazionale Superiore di Studi Avanzati / International School for Advanced Studies ( SISSA / ISAS ), Joint ALMA Observatory, Physique Corpusculaire et Cosmologie - Collège de France ( PCC ), Collège de France ( CdF ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Università di Trento, Institut d'Astrophysique de Paris ( IAP ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), HELFA - Hélium : du fondamental aux applications, Institut Néel ( NEEL ), Université Grenoble Alpes [Saint Martin d'Hères]-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes [Saint Martin d'Hères]-Centre National de la Recherche Scientifique ( CNRS ), Institut de recherche en astrophysique et planétologie ( IRAP ), Université Paul Sabatier - Toulouse 3 ( UPS ) -Observatoire Midi-Pyrénées ( OMP ) -Centre National de la Recherche Scientifique ( CNRS ), Westfälische Wilhelms-Universität Münster ( WWU ), AstroParticule et Cosmologie ( APC - UMR 7164 ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), ONERA - The French Aerospace Lab ( Chatillon ), ONERA, Laboratoire de Physique Subatomique et de Cosmologie ( LPSC ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Institute for Climate and Atmospheric Science [Leeds] ( ICAS ), University of Leeds, Universita degli Studi di Padova = University of Padua = Université de Padoue, Laboratoire de l'Accélérateur Linéaire ( LAL ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique ( LERMA ), École normale supérieure - Paris ( ENS Paris ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de Paris-Université de Cergy Pontoise ( UCP ), Université Paris-Seine-Université Paris-Seine-Centre National de la Recherche Scientifique ( CNRS ), Università degli Studi di Roma 'La Sapienza' [Rome], APC - Gravitation ( APC-Gravitation ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Max-Planck-Institut für Gravitationsphysik (Albert-Einstein-Institut), Max-Planck-Institut-Max-Planck-Institut, Laboratoire des Cryoréfrigérateurs et Cryogénie Spatiale ( LCCS ), Service des Basses Températures ( SBT - UMR 9004 ), Institut Nanosciences et Cryogénie ( INAC ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Grenoble Alpes ( UGA ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Grenoble Alpes ( UGA ) -Institut Nanosciences et Cryogénie ( INAC ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Grenoble Alpes ( UGA ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Grenoble Alpes ( UGA ), Centre d'étude spatiale des rayonnements ( CESR ), Université Paul Sabatier - Toulouse 3 ( UPS ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire Midi-Pyrénées ( OMP ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Génie Electrique de Grenoble ( G2ELab ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail ( ANSES Maisons-Alfort ), APC - Cosmologie, Collège de France ( CdF ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ) -Collège de France ( CdF ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ) -AstroParticule et Cosmologie ( APC - UMR 7164 ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Centre National de la Recherche Scientifique ( CNRS ) -Observatoire de Paris-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Istituto di Astrofisica Spaziale e Fisica cosmica - Bologna ( IASF-Bo ), Istituto Nazionale di Astrofisica ( INAF ), Department of Physics and Astronomy, University of British Columbia ( UBC ), National Center for Atmospheric Research [Boulder] ( NCAR ), Infrared Processing and Analysis Center ( IPAC ), California Institute of Technology ( CALTECH ), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies ( FEMTO-ST ), Université de Technologie de Belfort-Montbeliard ( UTBM ) -Ecole Nationale Supérieure de Mécanique et des Microtechniques ( ENSMM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Max-Planck-Institut für Astronomie ( MPIA ), International Center for Relativistic Astrophysics ( ICRA ), Laboratory for Experimental Medicine and Endocrinology, Catholic University of Leuven ( LEGENDO ), Université Catholique de Louvain ( UCL ), Università degli studi di Roma II, Istituto Nazionale di Fisica Nucleare, Sezione di Padova ( INFN, Sezione di Padova ), National Institute for Nuclear Physics ( INFN ), Antarctic Research a European Network for Astrophysics ( ARENA ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Laboratoire de Physique Théorique d'Orsay [Orsay] ( LPT ), Université Paris-Sud - Paris 11 ( UP11 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physique Nucléaire et de Hautes Énergies ( LPNHE ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), National High Magnetic Field Laboratory ( NHMFL ), Florida State University, Département de Physique des Particules (ex SPP) ( DPP ), National Science Foundation (US), European Research Council, Ministerio de Economía y Competitividad (España), Junta de Andalucía, Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), European Southern Observatory (ESO)-National Radio Astronomy Observatory (NRAO), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Hélium : du fondamental aux applications (NEEL - HELFA), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Westfälische Wilhelms-Universität Münster = University of Münster (WWU), DAAA, ONERA, Université Paris-Saclay [Châtillon], ONERA-Université Paris-Saclay, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), LERMA Cergy (LERMA), Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique et Atmosphères = Laboratory for Studies of Radiation and Matter in Astrophysics and Atmospheres (LERMA), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), European Space Astronomy Centre (ESAC), Agence Spatiale Européenne = European Space Agency (ESA), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), School of Physics and Astronomy [Manchester], Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Département de Physique des Particules (ex SPP) (DPhP), Collège de France (CdF)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Paris (ENS Paris)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université de Cergy Pontoise (UCP), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Université Grenoble Alpes (UGA)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Université de Franche-Comté (UFC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Technologie de Belfort-Montbeliard (UTBM), Université Catholique de Louvain (UCL), National Institute for Nuclear Physics (INFN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Ade, P. A. R., Aghanim, N., Ahmed, Z., Aikin, R. W., Alexander, K. D., Arnaud, M., Aumont, J., Baccigalupi, C., Banday, A. J., Barkats, D., Barreiro, R. B., Bartlett, J. G., Bartolo, N., Battaner, E., Benabed, K., Benoît, A., Benoit Lévy, A., Benton, S. J., Bernard, J. P., Bersanelli, M., Bielewicz, P., Bischoff, C. A., Bock, J. J., Bonaldi, A., Bonavera, L., Bond, J. R., Borrill, J., Bouchet, F. R., Boulanger, F., Brevik, J. A., Bucher, M., Buder, I., Bullock, E., Burigana, C., Butler, R. C., Buza, V., Calabrese, E., Cardoso, J. F., Catalano, A., Challinor, A., Chary, R. R., Chiang, H. C., Christensen, P. R., Colombo, L. P. L., Combet, C., Connors, J., Couchot, F., Coulais, A., Crill, B. P., Curto, A., Cuttaia, F., Danese, L., Davies, R. D., Davis, R. J., De Bernardis, P., De Rosa, A., De Zotti, G., Delabrouille, J., Delouis, J. M., Désert, F. X., Dickinson, C., Diego, J. M., Dole, H., Donzelli, S., Doré, O., Douspis, M., Dowell, C. D., Duband, L., Ducout, A., Dunkley, J., Dupac, X., Dvorkin, C., Efstathiou, G., Elsner, F., Enßlin, T. A., Eriksen, H. K., Falgarone, E., Filippini, J. P., Finelli, F., Fliescher, S., Forni, O., Frailis, M., Fraisse, A. A., Franceschi, E., Frejsel, A., Galeotta, S., Galli, S., Ganga, K., Ghosh, T., Giard, M., Gjerløw, E., Golwala, S. R., González Nuevo, J., Górski, K. M., Gratton, S., Gregorio, Anna, Gruppuso, A., Gudmundsson, J. E., Halpern, M., Hansen, F. K., Hanson, D., Harrison, D. L., Hasselfield, M., Helou, G., Henrot Versillé, S., Herranz, D., Hildebrandt, S. R., Hilton, G. C., Hivon, E., Hobson, M., Holmes, W. A., Hovest, W., Hristov, V. V., Huffenberger, K. M., Hui, H., Hurier, G., Irwin, K. D., Jaffe, A. H., Jaffe, T. R., Jewell, J., Jones, W. C., Juvela, M., Karakci, A., Karkare, K. S., Kaufman, J. P., Keating, B. G., Kefeli, S., Keihänen, E., Kernasovskiy, S. A., Keskitalo, R., Kisner, T. S., Kneissl, R., Knoche, J., Knox, L., Kovac, J. M., Krachmalnicoff, N., Kunz, M., Kuo, C. L., Kurki Suonio, H., Lagache, G., Lähteenmäki, A., Lamarre, J. M., Lasenby, A., Lattanzi, M., Lawrence, C. R., Leitch, E. M., Leonardi, R., Levrier, F., Lewis, A., Liguori, M., Lilje, P. B., Linden Vørnle, M., López Caniego, M., Lubin, P. M., Lueker, M., Macías Pérez, J. F., Maffei, B., Maino, D., Mandolesi, N., Mangilli, A., Maris, M., Martin, P. G., Martínez González, E., Masi, S., Mason, P., Matarrese, S., Megerian, K. G., Meinhold, P. R., Melchiorri, A., Mendes, L., Mennella, A., Migliaccio, M., Mitra, S., Miville Deschênes, M. A., Moneti, A., Montier, L., Morgante, G., Mortlock, D., Moss, A., Munshi, D., Murphy, J. A., Naselsky, P., Nati, F., Natoli, P., Netterfield, C. B., Nguyen, H. T., Nørgaard Nielsen, H. U., Noviello, F., Novikov, D., Novikov, I., O'Brient, R., Ogburn, R. W., Orlando, A., Pagano, L., Pajot, F., Paladini, R., Paoletti, D., Partridge, B., Pasian, F., Patanchon, G., Pearson, T. J., Perdereau, O., Perotto, L., Pettorino, V., Piacentini, F., Piat, M., Pietrobon, D., Plaszczynski, S., Pointecouteau, E., Polenta, G., Ponthieu, N., Pratt, G. W., Prunet, S., Pryke, C., Puget, J. L., Rachen, J. P., Reach, W. T., Rebolo, R., Reinecke, M., Remazeilles, M., Renault, C., Renzi, A., Richter, S., Ristorcelli, I., Rocha, G., Rossetti, M., Roudier, G., Rowan Robinson, M., Rubiño Martín, J. A., Rusholme, B., Sandri, M., Santos, D., Savelainen, M., Savini, G., Schwarz, R., Scott, D., Seiffert, M. D., Sheehy, C. D., Spencer, L. D., Staniszewski, Z. K., Stolyarov, V., Sudiwala, R., Sunyaev, R., Sutton, D., Suur Uski, A. S., Sygnet, J. F., Tauber, J. A., Teply, G. P., Terenzi, L., Thompson, K. L., Toffolatti, L., Tolan, J. E., Tomasi, M., Tristram, M., Tucci, M., Turner, A. D., Valenziano, L., Valiviita, J., Van Tent, B., Vibert, L., Vielva, P., Vieregg, A. G., Villa, F., Wade, L. A., Wandelt, B. D., Watson, R., Weber, A. C., Wehus, I. K., White, M., White, S. D. M., Willmert, J., Wong, C. L., Yoon, K. W., Yvon, D., Zacchei, A., and Zonca, A.

Subjects
Observational cosmology, High Energy Physics - Theory, Background radiations, Gravitational wave detectors and experiments, Astronomy, General Physics and Astronomy, ComputingMilieux_LEGALASPECTSOFCOMPUTING, Astrophysics, 01 natural sciences, Spectral line, General Relativity and Quantum Cosmology, law.invention, High Energy Physics - Phenomenology (hep-ph), law, Spectral behaviors, probe wmap observations gravity-waves polarization anisotropy emission submillimeter spectrum scaledust Physics, 010303 astronomy & astrophysics, QC, ComputingMilieux_MISCELLANEOUS, media_common, QB, Physics, Power-spectra, Lower frequencies, ta213, CDM modeling, Cross correlations, Dust emission, Joint analysis, Model variation, Polarization (waves), Synchrotron, High Energy Physics - Phenomenology, symbols, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Astrophysics - Cosmology and Nongalactic Astrophysics, Cosmology and Nongalactic Astrophysics (astro-ph.CO), media_common.quotation_subject, ta221, Cosmic background radiation, ta1171, Radio microwave, FOS: Physical sciences, General Relativity and Quantum Cosmology (gr-qc), Astrophysics::Cosmology and Extragalactic Astrophysics, [ PHYS.ASTR.CO ] Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], NO, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], symbols.namesake, Physics and Astronomy (all), Settore FIS/05 - Astronomia e Astrofisica, 0103 physical sciences, Planck, ta216, Astrophysics::Galaxy Astrophysics, ta115, ta114, 010308 nuclear & particles physics, Gravitational wave, High Energy Physics - Theory (hep-th), Sky, [SDU]Sciences of the Universe [physics], Data_GENERAL
Abstract

We report the results of a joint analysis of data from BICEP2/Keck Array and Planck. BICEP2 and Keck Array have observed the same approximately 400 deg2 patch of sky centered on RA 0 h, Dec. −57.5°. The combined maps reach a depth of 57 nK deg in Stokes Q and U in a band centered at 150 GHz. Planck has observed the full sky in polarization at seven frequencies from 30 to 353 GHz, but much less deeply in any given region (1.2 μK deg in Q and U at 143 GHz). We detect 150×353 cross-correlation in B modes at high significance. We fit the single- and cross-frequency power spectra at frequencies ≥150 GHz to a lensed-ΛCDM model that includes dust and a possible contribution from inflationary gravitational waves (as parametrized by the tensor-to-scalar ratio r), using a prior on the frequency spectral behavior of polarized dust emission from previous Planck analysis of other regions of the sky. We find strong evidence for dust and no statistically significant evidence for tensor modes. We probe various model variations and extensions, including adding a synchrotron component in combination with lower frequency data, and find that these make little difference to the r constraint. Finally, we present an alternative analysis which is similar to a map-based cleaning of the dust contribution, and show that this gives similar constraints. The final result is expressed as a likelihood curve for r, and yields an upper limit r0.05, National Science Foundation (NSF) ANT-0742818 ANT-1044978 ANT-0742592 ANT-1110087, JPL Research and Technology Development Fund from the NASA 06-ARPA206-0040 10-SAT10-0017, National Science Foundation (NSF) ANT-1145172 ANT-1145143 ANT-1145248, Keck Foundation (Caltech), European Space Agency, Centre National D'etudes Spatiales, CNRS/INSU-IN2P3-INP (France), Italian Space Agency (ASI), Italian National Research Council, Istituto Nazionale Astrofisica (INAF), National Aeronautics & Space Administration (NASA), United States Department of Energy (DOE), Science & Technology Facilities Council (STFC), UKSA (UK), Consejo Superior de Investigaciones Cientificas (CSIC), MINECO (Spain), JA (Spain), RES (Spain), Finnish Funding Agency for Technology & Innovation (TEKES), AoF (Finland), CSC (Finland), Helmholtz Association, German Aerospace Centre (DLR), Max Planck Society, CSA (Canada), DTU Space (Denmark), SER/SSO (Switzerland), RCN (Norway), Science Foundation Ireland, Portuguese Foundation for Science and Technology, ERC (EU), European Union (EU), Science & Technology Facilities Council (STFC) ST/K00106X/1 ST/K001051/1 ST/K002805/1 ST/L000768/1 ST/K004131/1 ST/N001206/1 ST/K000985/1 ST/L000636/1 ST/K003674/1 ST/M007685/1 ST/L000393/1 ST/L000652/1, Villum Fonden 10056

Published
2015

16. 10 years later : revisiting priorities for science and society a decade after the millennium ecosystem assessment

Author

MULDER, Christian, BENNETT, Elena M, BOHAN, David A., BONKOWSKI, Michael, CARPENTER, Stephen R, CHALMERS, Rachel M, CRAMER, Wolfgang, DURANCE, Isabelle, EISENHAUER, Nico, FONTAINE, Colin, HAUGHTON, Alison J, HETTELINGH, Jean-Paul, HINES, Jes, IBANEZ, Sébastien, JEPPESEN, Erik, KRUMINS, Jennifer Adams, MA, Athen, MANCINELLI, Giorgio, MASSOL, François, MCLAUGHLIN, Orla, NAEEM, Shahid, PASCUAL, Unai, PEÑUELAS, Josep, PETTORELLI, Nathalie, POCOCK, Michael J O, RAFFAELLI, Dave, RASMUSSEN, Jes J, RUSCH, Graciela, SCHERBER, Christoph, SETÄLÄ, H., SUTHERLAND, William J, VACHER, Corinne, VOIGT, Winfried, VONK, J Arie, WOOD, Stephen A, WOODWARD, Guy, National Institute for Public Health and the Environment [Bilthoven] (RIVM), Université McGill, Agroécologie [Dijon], Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Department of Terrestrial Ecology, Institut of Zoology, University of Cologne, University of Wisconsin-Madison, Singleton Hospital, Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UMR237-Aix Marseille Université (AMU)-Avignon Université (AU), School of Biosciences [Cardiff], Cardiff University, Université de Leipzig, German Centre for Integrative Biodiversity Research (iDiv), Centre d'Ecologie et des Sciences de la COnservation (CESCO), Muséum national d'Histoire naturelle (MNHN)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Rothamsted Research, Laboratoire d'Ecologie Alpine (LECA), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Joseph Fourier - Grenoble 1 (UJF)-Université Grenoble Alpes (UGA), Natl Environm Res Inst, Dept Freshwater Ecol, Silkeborg, Aarhus University [Aarhus], Montclair State University, Department of Computer Science (Queen Mary University of London), Queen Mary University of London (QMUL), University of Salento [Lecce], Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 (Evo-Eco-Paléo), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Columbia University [New York], University of Cambridge [UK] (CAM), Basque Center for Climate Change, CSIC, Global Ecology Unit, CREAF-CEAB-UAB, Cerdanyola del Vallès, 08193 Catalonia, Spain, Institute of Zoology, Zoological Society of London, Centre for Ecology and Hydrology [Wallingford] (CEH), Natural Environment Research Council (NERC), Environment Department [York], University of York [York, UK], Norwegian Institute for Nature Research (NINA), Agroecology, DNPW, Georg-August-University [Göttingen], Institute of Landscape Ecology, Westfälische Wilhelms-Universität Münster (WWU), Department of Ecological and Environmental Sciences, Conservation Science Group, Biodiversité, Gènes et Communautés, Institut National de la Recherche Agronomique (INRA), Friedrich-Schiller-Universität Jena, Institute for Biodiversity and Ecosystem Dynamics (IBED), University of Amsterdam [Amsterdam] (UvA), National Centre for Adult Stem Cell Research, Griffith University [Brisbane], School of Biological and Chemical Sciences, Mulder, Christian, Bennett, Elena M., Bohan, David A., Bonkowski, Michael, Carpenter, Stephen R., Chalmers, Rachel, Cramer, Wolfgang, Durance, Isabelle, Eisenhauer, Nico, Fontaine, Colin, Haughton, Alison J., Hettelingh, Jean Paul, Hines, Je, Ibanez, Sébastien, Jeppesen, Erik, Krumins, Jennifer Adam, Ma, Athen, Mancinelli, Giorgio, Massol, Françoi, Mclaughlin, Órla, Naeem, Shahid, Pascual, Unai, Peñuelas, Josep, Pettorelli, Nathalie, Pocock, Michael J. O., Raffaelli, Dave, Rasmussen, Jes J., Rusch, Graciela M., Scherber, Christoph, Setälä, Heikki, Sutherland, William J., Vacher, Corinne, Voigt, Winfried, Vonk, J. Arie, Wood, Stephen A., Woodward, Guy, McGill University = Université McGill [Montréal, Canada], Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Leipzig University, Biotechnology and Biological Sciences Research Council (BBSRC), Université Joseph Fourier - Grenoble 1 (UJF)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Montclair State University [USA] (MSU), Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 (Evo-Eco-Paléo (EEP)), Basque Center for Climate Change (BC3), Georg-August-University = Georg-August-Universität Göttingen, Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Department of Ecological and Environmental Sciences [Lahti], Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Biodiversité, Gènes & Communautés (BioGeCo), Institut National de la Recherche Agronomique (INRA)-Université de Bordeaux (UB), Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], Center for Limnology, Aix Marseille Université (AMU), Sorbonne Universités (COMUE), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Department of Bioscience [Roskilde], School of Electronic Engineering and Computer Science (EECS), Università del Salento, Université de Lille, Ikerbasque - Basque Foundation for Science, Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Environment Department, Sino-Danish Center for Education and Research, Partenaires INRAE, Agroecology, Yale School of Forestry and Environmental Studies, Imperial College London, Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), University of Helsinki, Aquatic Environmental Ecology (IBED, FNWI), National Institute for Public Health and the Environment [Bilthoven] ( RIVM ), Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, University of Wisconsin-Madison [Madison], Institut méditerranéen de biodiversité et d'écologie marine et continentale ( IMBE ), Université d'Avignon et des Pays de Vaucluse ( UAPV ) -Aix Marseille Université ( AMU ) -Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique ( CNRS ), German Centre for Integrative Biodiversity Research ( iDiv ), Centre d'Ecologie et des Sciences de la COnservation ( CESCO ), Centre National de la Recherche Scientifique ( CNRS ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Muséum National d'Histoire Naturelle ( MNHN ), Laboratoire d'Ecologie Alpine ( LECA ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Centre National de la Recherche Scientifique ( CNRS ), Department of Computer Science ( Queen Mary University of London ), Queen Mary University of London ( QMUL ), Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 ( Evo-Eco-Paléo ), Université de Lille-Centre National de la Recherche Scientifique ( CNRS ), University of Cambridge [UK] ( CAM ), Centre for Ecology and Hydrology [Wallingford] ( CEH ), Natural Environment Research Council ( NERC ), Norwegian Institute for Nature Research, 7485 Trondheim, Norway, Westfälische Wilhelms-Universität Münster ( WWU ), Institut National de Recherche Agronomique, Institute for Biodiversity and Ecosystem Dynamics ( IBED ), University of Amsterdam [Amsterdam] ( UvA ), and Griffith University

Subjects
services, Evolution, science and policy, assessment, [SDV]Life Sciences [q-bio], Services, Behavior and Systematics, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, ecological networks, human well-being, ComputingMilieux_MISCELLANEOUS, biodiversity, ecosystem, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], Ecology, Science and policy, Ecology, Evolution, Behavior and Systematics, Biodiversity, millennium, sustainability, Millennium Ecosystem Assessment, research questions, [ SDV.GEN.GPO ] Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], Research questions, Sustainability, ecosystem functioning, [SDE]Environmental Sciences, Ecological networks, Ecosystem functioning, Human well-being
Abstract

International audience; The study of ecological services (ESs) is fast becoming a cornerstone of mainstream ecology, largely because they provide a useful means of linking functioning to societal benefits in complex systems by connecting different organizational levels. In order to identify the main challenges facing current and future ES research, we analyzed the effects of the publication of the Millennium Ecosystem Assessment (MEA, 2005) on different disciplines. Within a set of topics framed around concepts embedded within the MEA, each co-author identified five key research challenges and, where feasible, suggested possible solutions. Concepts included those related to specific service types (i.e. provisioning, supporting, regulating, cultural, aesthetic services) as well as more synthetic issues spanning the natural and social sciences, which often linked a wide range of disciplines, as was the case for the application of network theory. By merging similar responses, and removing some of the narrower suggestions from our sample pool, we distilled the key challenges into a smaller subset. We review some of the historical context to the MEA and identify some of the broader scientific and philosophical issues that still permeate discourse in this field. Finally, we consider where the greatest advances are most likely to be made in the next decade and beyond.

Published
2015

17. Treatment efficacy of adipose-derived stem cells in experimental osteoarthritis is driven by high synovial activation and reflected by S100A8/A9 serum levels

Author

M.C. ter Huurne, Christian Jorgensen, Johannes Roth, P.L.E.M. van Lent, Thomas Vogl, W.B. van den Berg, R. Schelbergen, Danièle Noël, S. van Dalen, Arjen B. Blom, F.A.J. van de Loo, Radboud University Medical Center [Nijmegen], Radboud university [Nijmegen], University of Münster, Interdisciplinary Centre for Clinical Research (IZKF), Westfälische Wilhelms-Universität Münster (WWU)-Institute of Immunology, Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Cellules souches mésenchymateuses, environnement articulaire et immunothérapies de la polyarthrite rhumatoide, Université Montpellier 1 (UM1)-IFR3, Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM), 1. The authors would like to thank Birgitte Walgreen, Monique Helsen and Elly Vitters (Dept. Experimental Rheumatology, Radboud umc Nijmegen) and Niels Cremers (Dept. of orthodontics and craniofacial biology, Radboud umc, Nijmegen) for their excellent technical assistance.2. This study was financially supported by EU Framework Programme 7 ADIPOA ( Health-2009-1.4-3-241719 ) and by the Dutch Arthritis foundation (Reumafonds) no. 12-2-405.3. The funding source indicated above had no role in study design, in collection, analysis or interpretation of data, nor in writing the manuscript or decision to submit the manuscript., European Project: 241719,EC:FP7:HEALTH,FP7-HEALTH-2009-single-stage,ADIPOA(2010), Hennaut, Odile, ADIPOSE DERIVED STROMAL CELLS FOR OSTEOARTHRITIS - ADIPOA - - EC:FP7:HEALTH2010-01-01 - 2014-06-30 - 241719 - VALID, Radboud University [Nijmegen], Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Institute of Immunology-Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), and Institute of Immunology-Westfälische Wilhelms-Universität Münster (WWU)

Subjects
Cartilage, Articular, Pathology, Synovitis, [SDV]Life Sciences [q-bio], Interleukin-1beta, Adipose tissue, Osteoarthritis, Menisci, Tibial, Mice, 0302 clinical medicine, Orthopedics and Sports Medicine, 0303 health sciences, Reverse Transcriptase Polymerase Chain Reaction, Stem Cells, Synovial Membrane, Osteoarthritis, Knee, Pathophysiology, Animal models, [SDV] Life Sciences [q-bio], medicine.anatomical_structure, Adipose Tissue, medicine.symptom, Stem cell, Medial meniscus, Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5], S100, medicine.medical_specialty, Biomedical Engineering, Inflammation, Experimental OA, S100A8, 03 medical and health sciences, Rheumatology, medicine, Animals, Calgranulin B, Calgranulin A, Collagenases, RNA, Messenger, Molecular Biology, 030304 developmental biology, 030203 arthritis & rheumatology, business.industry, medicine.disease, Arthritis, Experimental, Adipose stem cells, Disease Models, Animal, business, Stem Cell Transplantation
Abstract

Contains fulltext : 137118.pdf (Publisher’s version ) (Closed access) OBJECTIVE: Synovitis is evident in a substantial subpopulation of patients with osteoarthritis (OA) and is associated with development of pathophysiology. Recently we have shown that adipose-derived stem cells (ASC) inhibit joint destruction in collagenase-induced experimental OA (CIOA). In the current study we explored the role of synovitis and alarmins S100A8/A9 in the immunomodulatory capacity of ASCs in experimental OA. METHOD: CIOA, characterized by synovitis, and surgical DMM (destabilization of medial meniscus) OA were treated locally with ASCs. Synovial activation, cartilage damage and osteophyte size were measured on histological sections. Cytokines in synovial washouts and serum were determined using Luminex or enzyme-linked immunosorbent assay (S100A8/A9), mRNA levels with reverse-transcriptase (RT)-qPCR. RESULTS: Local administration of ASCs at various time-points (days 7 or 14) after DMM induction had no effect on OA pathology. At day 7 of CIOA, already 6 h after ASC injection mRNA expression of pro-inflammatory mediators S100A8/A9, interleukin-1beta (IL-1beta) and KC was down-regulated in the synovium. IL-1beta protein, although low, was down-regulated by ASC-treatment of CIOA. S100A8/A9 protein levels were very high at 6 and 48 h and were decreased by ASC-treatment. The protective action of ASC treatment in CIOA was only found when high synovial inflammation was present at the time of deposition which was reflected by high serum S100A8/A9 levels. Finally, successful treatment resulted in significantly lower levels of serum S100A8/A9. CONCLUSION: Our study indicates that synovial activation rapidly drives anti-inflammatory and protective effects of intra-articularly deposited ASCs in experimental OA which is reflected by decreased S100A8/A9 levels. 9 p.

Published
2014

18. Atmospheric sulfur rearrangement 2.7 billion years ago: evidence for oxygenic photosynthesis

Author

Marc Peters, Christophe Thomazo, Mark D. Hannington, Mark Claire, Harald Strauss, Florian Kurzweil, Institut für Geologie und Paläontologie, Westfälische Wilhelms-Universität Münster ( WWU ), Institute of Geochemistry, Eberhard Karls Universität Tübingen, School of Environmental and Life Sciences, University of East Anglia [Norwich] ( UEA ), Biogéosciences [Dijon] ( BGS ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), Laboratory of Resource Engineering and Remediation, Chinese Academy of Sciences [Beijing] ( CAS ), Department of Earth Sciences, University of Ottawa, Funding from the Deutsche Forschungsgemeinschaft (Str 281/30-1)., Westfälische Wilhelms-Universität Münster (WWU), Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, University of East Anglia [Norwich] (UEA), Biogéosciences [UMR 6282] [Dijon] (BGS), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Chinese Academy of Sciences [Beijing] (CAS), Department of Earth Sciences [Ottawa], and University of Ottawa [Ottawa]

Subjects
010504 meteorology & atmospheric sciences, Archean, [SDE.MCG]Environmental Sciences/Global Changes, Geochemistry, chemistry.chemical_element, multiple sulfur isotopes, MIF-S, 010502 geochemistry & geophysics, Photosynthesis, 01 natural sciences, Atmosphere, late Archean, Geochemistry and Petrology, [SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistry, Earth and Planetary Sciences (miscellaneous), Great Oxidation Event, 0105 earth and related environmental sciences, atmospheric oxygenation, Great Oxygenation Event, Early Earth, Mass-independent fractionation, [ SDU.STU.GC ] Sciences of the Universe [physics]/Earth Sciences/Geochemistry, Anoxic waters, Sulfur, [ SDE.MCG ] Environmental Sciences/Global Changes, Geophysics, chemistry, 13. Climate action, Space and Planetary Science, Geology
Abstract

10 pages; International audience; Mass-independently fractionated sulfur isotopes (MIF-S) provide strong evidence for an anoxic atmosphere during the Archean. Moreover, the temporal evolution of MIF-S shows increasing magnitudes between 2.7 and 2.5 Ga until the start of the Great Oxidation Event (G.O.E.) at around 2.4 Ga. The conclusion of a completely anoxic atmosphere up to the G.O.E. is in contrast to recent studies on redox-sensitive elements, which suggest slightly oxidizing conditions during continental weathering already several hundred million years prior to the G.O.E. In order to investigate this apparent inconsistency, we present multiple sulfur isotopes for 2.71 Ga pyritic black shales derived from the Kidd Creek area, Ontario, Canada. These samples display high positive Δ33S values up to 3.8‰ and the typical late Archean slope in Δ36S/Δ33S of −0.9. In contrast, the time period before (3.2-2.73 Ga) is characterized by greatly attenuated MIF-S magnitudes and a slope in Δ36S/Δ33S of −1.5. We attribute the increase in Δ33S magnitude as well as the contemporaneous change in the slope of Δ36S/Δ33S to changes in the relative reaction rate of different MIF-S source reactions and changes in atmospheric sulfur exit channels. Both of these are dependent on atmospheric CH4:CO2 and O2 mixing ratios. We propose a distinct change in atmospheric composition at 2.7 Ga resulting from increased fluxes of oxygen and methane as the best explanation for the observed Neoarchean MIF-S record. Our data and modeling results suggest that oxygenic photosynthesis was a major contributor to primary productivity 2.7 billion years ago.

Published
2013

19. Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2

Author

Mulligan, Anna Marie, Couch, Fergus J, Barrowdale, Daniel, Domchek, Susan M, Eccles, Diana, Nevanlinna, Heli, Ramus, Susan J, Robson, Mark, Sherman, Mark, Spurdle, Amanda B, Wappenschmidt, Barbara, Lee, Andrew, McGuffog, Lesley, Healey, Sue, Sinilnikova, Olga M, Janavicius, Ramunas, Hansen, Thomas vO, Nielsen, Finn C, Ejlertsen, Bent, Osorio, Ana, Muñoz-Repeto, Iván, Durán, Mercedes, Godino, Javier, Pertesi, Maroulio, Benítez, Javier, Peterlongo, Paolo, Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Cattaneo, Elisa, Bonanni, Bernardo, Viel, Alessandra, Pasini, Barbara, Papi, Laura, Ottini, Laura, Savarese, Antonella, Bernard, Loris, Radice, Paolo, Hamann, Ute, Verheus, Martijn, Meijers-Heijboer, Hanne EJ, Wijnen, Juul, Gómez García, Encarna B, Nelen, Marcel R, Kets, C Marleen, Seynaeve, Caroline, Tilanus-Linthorst, Madeleine MA, van der Luijt, Rob B, van Os, Theo, Rookus, Matti, Frost, Debra, Jones, J Louise, Evans, D Gareth, Lalloo, Fiona, Eeles, Ros, Izatt, Louise, Adlard, Julian, Davidson, Rosemarie, Cook, Jackie, Donaldson, Alan, Dorkins, Huw, Gregory, Helen, Eason, Jacqueline, Houghton, Catherine, Barwell, Julian, Side, Lucy E, McCann, Emma, Murray, Alex, Peock, Susan, Godwin, Andrew K, Schmutzler, Rita K, Rhiem, Kerstin, Engel, Christoph, Meindl, Alfons, Ruehl, Ina, Arnold, Norbert, Niederacher, Dieter, Sutter, Christian, Deissler, Helmut, Gadzicki, Dorothea, Kast, Karin, Preisler-Adams, Sabine, Varon-Mateeva, Raymonda, Schoenbuchner, Ines, Fiebig, Britta, Heinritz, Wolfram, Schäfer, Dieter, Gevensleben, Heidrun, Caux-Moncoutier, Virginie, Fassy-Colcombet, Marion, Cornelis, François, Mazoyer, Sylvie, Léoné, Mélanie, Boutry-Kryza, Nadia, Hardouin, Agnès, Berthet, Pascaline, Muller, Danièle, Fricker, Jean-Pierre, Mortemousque, Isabelle, Pujol, Pascal, Coupier, Isabelle, Lebrun, Marine, Kientz, Caroline, Longy, Michel, Sevenet, Nicolas, Stoppa-Lyonnet, Dominique, Isaacs, Claudine, Caldes, Trinidad, de la Hoya, Miguel, Heikkinen, Tuomas, Aittomäki, Kristiina, Blanco, Ignacio, Lazaro, Conxi, Barkardottir, Rosa B, Soucy, Penny, Dumont, Martine, Simard, Jacques, Montagna, Marco, Tognazzo, Silvia, D'Andrea, Emma, Fox, Stephen, Yan, Max, Rebbeck, Tim, Olopade, Olufunmilayo, Weitzel, Jeffrey N, Lynch, Henry T, Ganz, Patricia A, Tomlinson, Gail E, Wang, Xianshu, Fredericksen, Zachary, Pankratz, Vernon S, Lindor, Noralane M, Szabo, Csilla, Offit, Kenneth, Sakr, Rita, Gaudet, Mia, Bhatia, Jasmine, Kauff, Noah, Singer, Christian F, Tea, Muy-Kheng, Gschwantler-Kaulich, Daphne, Fink-Retter, Anneliese, Mai, Phuong L, Greene, Mark H, Imyanitov, Evgeny, O'Malley, Frances P, Ozcelik, Hilmi, Glendon, Gordon, Toland, Amanda E, Gerdes, Anne-Marie, Thomassen, Mads, Kruse, Torben A, Jensen, Uffe Birk, Skytte, Anne-Bine, Caligo, Maria A, Soller, Maria, Henriksson, Karin, Wachenfeldt, von Anna, Arver, Brita, Stenmark-Askmalm, Marie, Karlsson, Per, Ding, Yuan Chun, Neuhausen, Susan L, Beattie, Mary, Pharoah, Paul DP, Moysich, Kirsten B, Nathanson, Katherine L, Karlan, Beth Y, Gross, Jenny, John, Esther M, Daly, Mary B, Buys, Saundra M, Southey, Melissa C, Hopper, John L, Terry, Mary Beth, Chung, Wendy, Miron, Alexander F, Goldgar, David, Chenevix-Trench, Georgia, Easton, Douglas F, Andrulis, Irene L, Antoniou, Antonis C, Breast Cancer Family Registry, EMBRACE, GEMO Study Collaborators, HEBON, kConFab Investigators, Ontario Cancer Genetics Network, SWE-BRCA, CIMBA, Pediatric Surgery, Neurology, Medical Oncology, Surgery, Clinical Genetics, Department of Laboratory Medicine, St Michael's Hospital-Keenan Research Centre of the Li Ka Shing Knowledge Institute [Toronto], Department of Laboratory Medicine and Pathobiology, University of Toronto, Department of Laboratory Medicine and Pathology, Mayo Clinic, Centre for Cancer Genetic Epidemiology, University of Cambridge [UK] (CAM), Department of Medicine, University of Pennsylvania [Philadelphia]-Abramson Cancer Center, Faculty of Medicine, University of Southampton-University Hospital Southampton, Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Department of Preventive Medicine, University of Southern California (USC)-Keck School of Medicine [Los Angeles], University of Southern California (USC), Memorial Sloane Kettering Cancer Center [New York]-Weill Medical College of Cornell University [New York], Division of Cancer Epidemiology and Genetics, National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH)-National Institutes of Health [Bethesda] (NIH), Queensland Institute of Medical Research, Department of Gynaecology and Obstetrics, University Hospital of Cologne [Cologne]-Centre of Familial Breast and Ovarian Cancer-Centre for Integrated Oncology (CIO), Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Léon Bérard [Lyon]-Hospices Civils de Lyon (HCL), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Molecular and Regenerative Medicine, Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Clinics, State Research Institute Innovative Medicine Center, Center for Genomic Medicine, Copenhagen University Hospital-Rigshospitalet [Copenhagen], Copenhagen University Hospital, Department of Oncology, Human Genetics Group, Spanish National Cancer Research Centre-Spain and the Spanish Network on Rare Diseases, Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM-UVA), Instituto de investigación sanitaria de Aragón (IIS), Hospital clinico Universitario 'Lozano Blesa', Molecular Diagnostics Laboratory, National Center for Scientific Research 'Demokritos' (NCSR)-IRRP, Unit of Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS Istituto Nazionale Tumouri (INT), Fondazione Istituto FIRC di Oncologia Molecolare, IFOM, Istituto FIRC di Oncologia Molecolare (IFOM), Unit of Medical Genetics, Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Unit of Experimental Oncology 1, Centro di Riferimento Oncologico, Department of Genetics, Biology and Biochemistry, University of Turin, Medical Genetics Unit, Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Department of Molecular Medicine, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Division of Medical Oncology, Regina Elena Cancer Institute, Department of Experimental Oncology, Consortium for Genomics Technology (Cogentech)-Istituto Europeo di Oncologia. Milan, Molecular Genetics of Breast Cancer, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Department of Epidemiology, Netherlands Cancer Institute, Department of Clinical Genetics, VU Medical Center, Department of Human Genetics and Department of Clinical Genetics, Leiden University Medical Center (LUMC), Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Department of Human Genetics, Radboud University Medical Center [Nijmegen], Department of Medical Oncology, Erasmus University Medical Center [Rotterdam] (Erasmus MC)-Family Cancer Clinic, Department of Surgical Oncology, Department of Clinical Molecular Genetics, University Medical Center [Utrecht], Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA)-University of Amsterdam [Amsterdam] (UvA), Barts Cancer Institute, Queen Mary University of London (QMUL), Genetic Medicine, Manchester Academic Health Sciences Centre-Central Manchester University Hospitals, Oncogenetics Team, The Institute of Cancer Research and Royal Marsden, Guy's and St. Thomas' NHS Foundation Trust, Yorkshire Regional Genetics Service, Ferguson-Smith Centre for Clinical Genetics, Yorkhill Hospitals, Sheffield Clinical Genetics Service, Sheffield Children's NHS Foundation Trust, Clinical Genetics Department, St Michael's Hospital, North West Thames Regional Genetics Service, Kennedy-Galton Centre, North of Scotland Regional Genetics Service, University of Aberdeen-NHS Grampian, Nottingham Clinical Genetics Service, Nottingham University Hospitals NHS Trust, Cheshire and Merseyside Clinical Genetics Service, Liverpool Women's NHS Foundation Trust, Leicestershire Clinical Genetics Service, University Hospitals Leicester, North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children [London] (GOSH), All Wales Medical Genetics Services, Singleton Hospital, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center [Lawrence], Institute for Medical Informatics, Statistics and Epidemiology [Leipzig] (IMISE), Universität Leipzig [Leipzig], Klinikum Rechts der Isar, Ludwig-Maximillians University, University Hospital of Schleswig-Holstein (UKSH), University Hospital Düsseldorf, Institute of Human Genetics, Heidelberg University Hospital [Heidelberg], Universitätsklinikum Ulm - University Hospital of Ulm, Institute of Cell and Molecular Pathology, Hannover Medical School [Hannover] (MHH), University Hospital Carl Gustav Carus, Westfälische Wilhelms-Universität Münster (WWU), Campus Virchov Klinikum, Department of Medical Genetic, Julius-Maximilians-Universität Würzburg [Wurtzbourg, Allemagne] (JMU)-Institute of Human Genetics-Centre of Familial Breast and Ovarian Cancer, Universität Regensburg (UR), University Hospital, Frankfurt, Breakthrough Breast Cancer Research Centre, Institute of cancer research, Service de Génétique Oncologique, Institut Curie [Paris], Service de génétique [Avicenne], Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Sud Francilien, CH Evry-Corbeil, CHU Clermont-Ferrand, Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU), Unité d'oncogénétique, CRLCC Paul Strauss, Service de génétique [Tours], Hôpital Bretonneau-Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Service de génétique médicale [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, Service de Génétique Clinique Chromosomique et Moléculaire, CHU Saint-Etienne, Validation et identification de nouvelles cibles en oncologie (VINCO), Institut Bergonié [Bordeaux], UNICANCER-UNICANCER-Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de génétique et biologie des cancers (U830), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Lombardi Comprehensive Cancer Center, Georgetown University, Molecular Oncology Laboratory, Hospital Clínico San Carlos, Hereditary Cancer Program, Institut Català d'Oncologia-Hospital Duran i Reynals, Department of Pathology, Landspitali University Hospital, University of Iceland [Reykjavik], Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec, Research Chair in Oncogenetics, Université Laval [Québec] (ULaval), Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS, Department of Oncology and Surgical Sciences, Universita degli Studi di Padova, Peter MacCallum Cancer Centre, Peter MacCallum Cancer Center, Department of Anatomical Pathology, Prince of Wales Hospital, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania [Philadelphia]-University of Pennsylvania [Philadelphia], University of Chicago, City of Hope Comprehensive Cancer Center and Department of Population Sciences, Beckman Research Institute, Departments of Medicine, and Preventive Medicine and Public Health, Creighton University, Jonsson Comprehensive Cancer Center, University of California [Los Angeles] (UCLA), University of California-University of California, Department of Internal Medicine, The University of Texas Health Science Center at Houston (UTHealth)-Harold C. Simmons Comprehensive Cancer Center, Department of Pediatrics, The University of Texas Health Science Center at Houston (UTHealth), Department of Medical Genetics, University of Delaware [Newark], Epidemiology Research Program, American Cancer Society, Department of Obstetrics/Gynaecology and Comprehensive Cancer Center, Medizinische Universität Wien = Medical University of Vienna, Laboratory of Molecular Oncology, N.N. Petrov Institute of Oncology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital [Toronto, Canada] (MSH), Prevention & Cancer Control, Cancer Care Ontario, Departments of Molecular VirologyImmunology and Medical Genetics and Internal Medicine, Ohio State University [Columbus] (OSU), University of Copenhagen = Københavns Universitet (KU)-Rigshospital, Odense University Hospital, Aarhus University Hospital, Vejle Hospital, Section of Genetic Oncology, University of Pisa - Università di Pisa, Lund University Hospital, Oncological Centre, Karolinska University Hospital [Stockholm], Department of Clinical and Experimental Medicine, Linköping University (LIU), Sahlgrenska University Hospital [Gothenburg], Department of Population Sciences, Beckman Research Institute of the City of Hope, UCSF Cancer Risk Program and Departments of Medicine and Epidemiology and Biostatistics, University of California [San Francisco] (UCSF), Department of Cancer Prevention and Control, Roswell Park Cancer Institute [Buffalo], Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cancer Prevention Institute of California, Fox Chase Cancer Center, Department of Oncological Sciences, University of Utah-Huntsman Cancer Institute, Genetic Epidemiology Laboratory, University of Melbourne, Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Columbia University [New York], Department of Cancer Biology, Dana-Farber Cancer Institute [Boston], Department of Dermatology, University of Utah School of Medicine [Salt Lake City], This work was supported by Cancer Research UK grants C12292/A11174 and C1287/A10118. The research leading to these results has received funding from the European Community's Seventh Framework Programme under grant agreement n° 223175 (HEALTH-F2-2009-223175). ACA is a CR-UK Senior Cancer Research Fellow, DFE is CR-UK Principal Research Fellow., for Breast Cancer Family Registry, for EMBRACE, for Ontario Cancer Genetics Network, for SWE-BRCA, for CIMBA, European Project: 223175,EC:FP7:HEALTH,FP7-HEALTH-2007-B,COGS(2009), BMC, Ed., Collaborative Oncological Gene-environment Study - COGS - - EC:FP7:HEALTH2009-05-01 - 2014-01-31 - 223175 - VALID, University of Pennsylvania-Abramson Cancer Center, Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Università degli studi di Torino = University of Turin (UNITO), Università degli Studi di Firenze = University of Florence (UniFI), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Consortium for Genomics Technology (Cogentech)-Istituto Europeo di Oncologia [Milano] (IEO), University of Kansas Medical Center [Kansas City, KS, USA], Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Julius-Maximilians-Universität Würzburg (JMU)-Institute of Human Genetics-Centre of Familial Breast and Ovarian Cancer, Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau, Georgetown University [Washington] (GU), Università degli Studi di Padova = University of Padua (Unipd), University of Pennsylvania-University of Pennsylvania, University of California (UC)-University of California (UC), Rigshospital-University of Copenhagen = Københavns Universitet (UCPH), Vejle Hospital [Danemark], University of California [San Francisco] (UC San Francisco), Lee, Andrew [0000-0003-0677-0252], Pharoah, Paul [0000-0001-8494-732X], Easton, Douglas [0000-0003-2444-3247], Antoniou, Antonis [0000-0001-9223-3116], Apollo - University of Cambridge Repository, University of Cambridge [UK] ( CAM ), University of Southampton [Southampton]-University Hospital Southampton, University of Southern California ( USC ) -Keck School of Medicine [Los Angeles], Memorial Sloan-Kettering Cancer Center-Weill Medical College of Cornell University [New York], National Cancer Institute ( NIH ), Centre Léon Bérard [Lyon]-Hospices Civils de Lyon ( HCL ), Centre de Recherche en Cancérologie de Lyon ( CRCL ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Instituto de investigación sanitaria de Aragón ( IIS ), National Center for Scientific Research 'Demokritos' ( NCSR ) -IRRP, IFOM, University of Florence, Università degli Studi di Roma 'La Sapienza' [Rome], Deutsches Krebsforschungszentrum ( DKFZ ), Erasmus University Medical Center-Family Cancer Clinic, University Medical Center Utrecht, Academic Medical Center [Amsterdam] ( AMC ), University of Amsterdam [Amsterdam] ( UvA ) -University of Amsterdam [Amsterdam] ( UvA ), Queen Mary University of London ( QMUL ), Sheffield Children's Hospital, University Hospitals of Leicester, Great Ormond Street Hospital for Children [London] ( GOSH ), University of Kansas Medical Center, Institute for Medical Informatics, Statistics and Epidemiology [Leipzig] ( IMISE ), University of Leipzig, University Hospital Ulm, Hannover Medical School [Hannover] ( MHH ), Westfälische Wilhelms-Universität Münster ( WWU ), University Wurzburg-Institute of Human Genetics-Centre of Familial Breast and Ovarian Cancer, University Regensburg, INSTITUT CURIE, Université Paris 13 ( UP13 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Avicenne, Centre Hospitalier Universitaire Clermont-Ferrand, Centre François Baclesse, Hôpital Bretonneau-CHRU Tours, Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Hôpital Arnaud de Villeneuve, Validation et identification de nouvelles cibles en oncologie ( VINCO ), Université Bordeaux Segalen - Bordeaux 2-Institut Bergonié - CRLCC Bordeaux-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Unité de génétique et biologie des cancers ( U830 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut Curie-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Laval University [Québec], University of Padua and Istituto Oncologico Veneto IOV - IRCCS, University of Pennsylvania Perelman School of Medicine, University of California at Los Angeles [Los Angeles] ( UCLA ), University of Texas at Houston [Houston] ( UTHealth ) -Harold C. Simmons Comprehensive Cancer Center, University of Texas Health Science, Medical University of Vienna, Mount Sinai Hospital, The Ohio State University Comprehensive Cancer Center, University of Copenhagen ( KU ) -Rigshospital, University of Pisa [Pisa], Linköping University ( LIU ), Sahlgrenska University Hospital, the Beckman Research Institute of the City of Hope, University of California [San Francisco] ( UCSF ), European Project : 223175,EC:FP7:HEALTH,FP7-HEALTH-2007-B,COGS ( 2009 ), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris 13 (UP13), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Bergonié [Bordeaux], UNICANCER-UNICANCER-Université Bordeaux Segalen - Bordeaux 2, Human Genetics, Universiteit Leiden-Universiteit Leiden, Nottingham University Hospitals NHS Trust (NUH), Universität Leipzig, Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), and Roswell Park Cancer Institute [Buffalo] (RPCI)

Subjects
Risk, Heterozygote, endocrine system diseases, Population, Genes, BRCA2, Genes, BRCA1, Social Sciences, Estrogen receptor, Single-nucleotide polymorphism, [SDV.CAN]Life Sciences [q-bio]/Cancer, Breast Neoplasms, Biology, Polymorphism, Single Nucleotide, [ SDV.CAN ] Life Sciences [q-bio]/Cancer, 03 medical and health sciences, 610 Medical sciences Medicine, 0302 clinical medicine, Breast cancer, [SDV.CAN] Life Sciences [q-bio]/Cancer, SDG 3 - Good Health and Well-being, Genotype, medicine, Humans, Genetic Predisposition to Disease, education, skin and connective tissue diseases, Estrogen Receptor Status, Alleles, 030304 developmental biology, Medicine(all), 0303 health sciences, education.field_of_study, Samhällsvetenskap, medicine.disease, 3. Good health, TOX3, Receptors, Estrogen, Cancer and Oncology, 030220 oncology & carcinogenesis, Mutation, Cancer research, Female, Ovarian cancer, Receptors, Progesterone, Research Article
Abstract

[Introduction]: Previous studies have demonstrated that common breast cancer susceptibility alleles are differentially associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumour. [Methods]: We used genotype data on up to 11,421 BRCA1 and 7,080 BRCA2 carriers, of whom 4,310 had been affected with breast cancer and had information on either ER or PR status of the tumour, to assess the associations of 12 loci with breast cancer tumour characteristics. Associations were evaluated using a retrospective cohort approach. [Results]: The results suggested stronger associations with ER-positive breast cancer than ER-negative for 11 loci in both BRCA1 and BRCA2 carriers. Among BRCA1 carriers, single nucleotide polymorphism (SNP) rs2981582 (FGFR2) exhibited the biggest difference based on ER status (per-allele hazard ratio (HR) for ER-positive = 1.35, 95% CI: 1.17 to 1.56 vs HR = 0.91, 95% CI: 0.85 to 0.98 for ER-negative, P-heterogeneity = 6.5 × 10-6). In contrast, SNP rs2046210 at 6q25.1 near ESR1 was primarily associated with ER-negative breast cancer risk for both BRCA1 and BRCA2 carriers. In BRCA2 carriers, SNPs in FGFR2, TOX3, LSP1, SLC4A7/NEK10, 5p12, 2q35, and 1p11.2 were significantly associated with ER-positive but not ER-negative disease. Similar results were observed when differentiating breast cancer cases by PR status. [Conclusions]: The associations of the 12 SNPs with risk for BRCA1 and BRCA2 carriers differ by ER-positive or ER-negative breast cancer status. The apparent differences in SNP associations between BRCA1 and BRCA2 carriers, and non-carriers, may be explicable by differences in the prevalence of tumour subtypes. As more risk modifying variants are identified, incorporating these associations into breast cancer subtype-specific risk models may improve clinical management for mutation carriers.

Published
2011

20. Haplotype structure in Ashkenazi Jewish BRCA1 and BRCA2 mutation carriers

Author

Im, Kate M., Kirchhoff, Tomas, Wang, Xianshu, Green, Todd, Chow, Clement Y., Vijai, Joseph, Korn, Joshua, Gaudet, Mia M., Fredericksen, Zachary, Pankratz, V. Shane, Guiducci, Candace, Crenshaw, Andrew, McGuffog, Lesley, Kartsonaki, Christiana, Morrison, Jonathan, Healey, Sue, Sinilnikova, Olga M., Mai, Phuong L., Greene, Mark H., Piedmonte, Marion, Rubinstein, Wendy S., Hogervorst, Frans B. L., Rookus, Matti A., Collee, Margriet J., Hoogerbrugge, Nicoline, van Asperen, Christi J., Meijers-Heijboer, Hanne E. J., van Roozendaal, Cees E., Caldes, Trinidad, Perez Segura, Pedro, Jakubowska, Anna, Lubinski, Jan, Huzarski, Tomasz, Blecharz, Pawel, Nevanlinna, Heli, Aittomaki, Kristiina, Lazaro, Conxi, Blanco, Ignacio, Barkardottir, Rosa B., Montagna, Marco, D'Andrea, Emma, Devilee, Peter, Olopade, Olufunmilayo I., Neuhausen, Susan L., Peissel, Bernard, Bonanni, Bernardo, Peterlongo, Paolo, Singer, Christian F., Rennert, Gad, Lejbkowicz, Flavio, Andrulis, Irene L., Glendon, Gord, Ozcelik, Hilmi, Toland, Amanda Ewart, Caligo, Maria Adelaide, Beattie, Mary S., Chan, Salina B., Domchek, Susan M., Nathanson, Katherine L., Rebbeck, Timothy R., Phelan, Catherine M., Narod, Steven A., John, Esther M., Hopper, John L., Buys, Saundra, Daly, Mary B., Southey, Melissa C., Terry, Mary Beth, Tung, Nadine, Hansen, Thomas V. O., Osorio, Ana, Benitez, Javier, Duran, Mercedes, Weitzel, Jeffrey N., Garber, Judy, Hamann, Ute, Peock, Susan, Cook, Margaret, Oliver, Clare T., Frost, Debra, Platte, Radka, Evans, D. Gareth, Eeles, Ros, Izatt, Louise, Paterson, Joan, Brewer, Carole, Hodgson, Shirley V., Morrison, Patrick J., Porteous, Mary E., Walker, Lisa, Rogers, Mark T., Side, Lucy E., Godwin, Andrew K., Schmutzler, Rita K., Wappenschmidt, Barbara, Laitman, Yael, Meindl, Alfons, Deissler, Helmut, Varon-Mateeva, Raymonda, Preisler-Adams, Sabine, Kast, Karin, Venat-Bouvet, Laurence, Stoppa-Lyonnet, Dominique, Chenevix-Trench, Georgia, Easton, Douglas F., Klein, Robert J., Daly, Mark J., Friedman, Eitan, Dean, Michael, Clark, Andrew G., Altshuler, David M., Antoniou, Antonis C., Couch, Fergus J., Offit, Kenneth, Gomez Garcia, Encarna, Blok, Marinus, Gold, Bert, center for cancer research, Cancer inflammation, Department of Environmental Medicine, New York University School of Medicine-NYU Cancer Institute, Department of Laboratory Medicine and Pathology, Mayo Clinic, Department of Genetics [Boston], Harvard Medical School [Boston] ( HMS ), Cornell University, Department of Medical Genetics, Centre for Cancer Genetic Epidemiology, University of Cambridge [UK] ( CAM ), Queensland Institute of Medical Research, Centre de Recherche en Cancérologie de Lyon ( CRCL ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Centre Léon Bérard [Lyon], Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Institutes of Health ( NIH ) -National Cancer Institute ( NIH ), Statistical and Data Center, Roswell Park Cancer Institute [Buffalo], Department of Clinical Genetics, Erasmus University Medical Center-Family Cancer Clinic, Human Genetics, Molecular Oncology Laboratory, Hospital Clínico San Carlos, Department of Genetics and Pathology, Pomeranian Medical University-International Hereditary Cancer Centre, International Hereditary Cancer Center, Pomeranian Medical University, Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Molecular Diagnostic Unit, IDIBELL-Catalan Institute of Oncology, Genetic Counselling Unit, Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS, Department of Oncology and Surgical Sciences, University of Padua and Istituto Oncologico Veneto IOV - IRCCS, Department of Genetic Epidemiology, Leiden University Medical Center (LUMC), Unit of Medical Genetics, Fondazione IRCCS Istituto Nazionale Tumouri (INT), Division of Cancer Prevention and Genetics, Unit of Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS Istituto Nazionale Tumouri (INT)-Fondazione Istituto FIRC di Oncologia Molecolare, Department of Community Medicine and Epidemiology, CHS National Cancer Control Center, Ontario Cancer Genetics Network, Cancer Care Ontario, Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto-Cancer Care Ontario, Samuel Lunenfeld Research Institute, Mount Sinai Hospital ( MSH ), Section of Genetic Oncology, University Hospital and University of Pisa, Depts of Medicine and Biostatistics and Epidemology, Abramson Family Cancer Research Institute-University of Pennsylvania School of Medicine, Women's College Research Institute, University of Toronto, Human Genetics Group, Spanish National Cancer Research Centre, Biomedical Research Centre Network for Rare Diseases, CIBER de Enfermedades Raras (CIBERER), Institute of Biology and Molecular Genetics, Universidad de Valladolid [Valladolid] ( UVa ), Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum ( DKFZ ), Genetic Medicine, Manchester Academic Health Sciences Centre-Central Manchester University Hospitals, Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, Addenbrookes Hospital, Royal Devon & Exeter Hospital, Medical Genetics Unit, University College of London [London] ( UCL ), South East of Scotland Regional Genetics Service, Western General Hospital, Oxford Regional Genetics Service, Churchill Hospital Oxford Centre for Haematology, Department of Gynaecology and Obstetrics, University Hospital of Cologne [Cologne]-Centre of Familial Breast and Ovarian Cancer-Centre for Integrated Oncology (CIO), The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Technical University of Munich ( TUM ), University Hospital Ulm, Charite berlin, Westfälische Wilhelms-Universität Münster ( WWU ), University Hospital Carl Gustav Carus, Service d'Oncologie médicale [CHU Limoges], CHU Limoges, Service de Génétique Oncologique, INSTITUT CURIE, Unité de génétique et biologie des cancers ( U830 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut Curie-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Cancer Research U.K. Genetic Epidemiology Unit, Strangeways Research Laboratory, Genetic Epidemiology Unit, Department of Public Health and Primary Care, Sackler Faculty of Medicine, Tel Aviv University [Tel Aviv], Department of Molecular Biology and Genetics, Cornell University, Clinical Genetics Service, Memorial Sloane Kettering Cancer Center [New York], New York University School of Medicine, NYU System (NYU)-NYU System (NYU)-NYU Cancer Institute, Harvard Medical School [Boston] (HMS), Cornell University [New York], University of Cambridge [UK] (CAM), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), National Institutes of Health [Bethesda] (NIH)-National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Erasmus University Medical Center [Rotterdam] (Erasmus MC)-Family Cancer Clinic, Universita degli Studi di Padova, Mount Sinai Hospital [Toronto, Canada] (MSH), Abramson Family Cancer Research Institute-Perelman School of Medicine, University of Pennsylvania [Philadelphia]-University of Pennsylvania [Philadelphia], Universidad de Valladolid [Valladolid] (UVa), German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), University College of London [London] (UCL), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Universitätsklinikum Ulm - University Hospital of Ulm, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Westfälische Wilhelms-Universität Münster (WWU), Institut Curie [Paris], Unité de génétique et biologie des cancers (U830), Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5), Genetica & Celbiologie, RS: GROW - School for Oncology and Reproduction, Klinische Genetica, Universitat de Barcelona, Internal Medicine, Pediatric Surgery, Centre de Recherche en Cancérologie de Lyon (CRCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Mount Sinai Hospital (MSH), Technical University of Munich (TUM), Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin, Institut Curie, Université Paris Descartes - Paris 5 (UPD5)-Institut Curie-Institut National de la Santé et de la Recherche Médicale (INSERM), Human genetics, and CCA - Oncogenesis

Subjects
Linkage disequilibrium, endocrine system diseases, MESH : BRCA2 Protein, MESH : Genotype, Deafness, MESH: Base Sequence, MESH: Founder Effect, [ SDV.CAN ] Life Sciences [q-bio]/Cancer, MESH: Genotype, 0302 clinical medicine, MESH: BRCA2 Protein, MESH : Polychondritis, Relapsing, MESH : Female, Polychondritis, Relapsing, skin and connective tissue diseases, Genetics (clinical), Sequence Deletion, MESH: Heterozygote, Genetics, 0303 health sciences, education.field_of_study, BRCA1 Protein, Tay-Sachs disease, MESH: Sequence Deletion, Founder Effect, Ashkenazi jews, 3. Good health, MESH : Jews, MESH : Computer Simulation, 030220 oncology & carcinogenesis, MESH: Jews, Female, MESH: Polychondritis, Relapsing, Heterozygote, MESH : Heterozygote, MESH : Deafness, Genotype, Hereditary cancer and cancer-related syndromes Genetics and epigenetic pathways of disease [ONCOL 1], Population, MESH : Founder Effect, MESH: Deafness, MESH: Arthritis, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, Article, Chromosomes, 03 medical and health sciences, SDG 3 - Good Health and Well-being, MESH: Computer Simulation, medicine, Humans, Computer Simulation, MESH : BRCA1 Protein, education, Allele frequency, MESH : Haplotypes, 030304 developmental biology, MESH: BRCA1 Protein, BRCA2 Protein, MESH: Humans, Hereditary cancer and cancer-related syndromes [ONCOL 1], Base Sequence, Arthritis, MESH : Sequence Deletion, Haplotype, MESH : Humans, MESH: Haplotypes, MESH : Arthritis, medicine.disease, Cromosomes, Haplotypes, Jews, MESH : Base Sequence, Selective sweep, MESH: Female, Founder effect
Abstract

Three founder mutations in BRCA1 and BRCA2 contribute to the risk of hereditary breast and ovarian cancer in Ashkenazi Jews (AJ). They are observed at increased frequency in the AJ compared to other BRCA mutations in Caucasian non-Jews (CNJ). Several authors have proposed that elevated allele frequencies in the surrounding genomic regions reflect adaptive or balancing selection. Such proposals predict long-range linkage disequilibrium (LD) resulting from a selective sweep, although genetic drift in a founder population may also act to create long-distance LD. To date, few studies have used the tools of statistical genomics to examine the likelihood of long-range LD at a deleterious locus in a population that faced a genetic bottleneck. We studied the genotypes of hundreds of women from a large international consortium of BRCA1 and BRCA2 mutation carriers and found that AJ women exhibited long-range haplotypes compared to CNJ women. More than 50% of the AJ chromosomes with the BRCA1 185delAG mutation share an identical 2.1 Mb haplotype and nearly 16% of AJ chromosomes carrying the BRCA2 6174delT mutation share a 1.4 Mb haplotype. Simulations based on the best inference of Ashkenazi population demography indicate that long-range haplotypes are expected in the context of a genome-wide survey. Our results are consistent with the hypothesis that a local bottleneck effect from population size constriction events could by chance have resulted in the large haplotype blocks observed at high frequency in the BRCA1 and BRCA2 regions of Ashkenazi Jews.

Published
2011

21. Response-Cretaceous Extinctions

Author

Richard A. F. Grieve, Penny Barton, Arthur R. Sweet, Robert P. Speijer, Peter Schulte, Vivi Vajda, Michael T. Whalen, David A. Kring, Timothy J. Bralower, Alessandro Montanari, Wolfgang Kiessling, Charles S. Cockell, Eric Robin, Joanna Morgan, Clive R. Neal, Elisabetta Pierazzo, Gail L. Christeson, Ignacio Arenillas, Kenneth G. MacLeod, Kirk R. Johnson, Sean P. S. Gulick, Jay Melosh, J.M. Grajales-Nishimura, Tobias Salge, Gareth S. Collins, Greg Ravizza, Jaime Urrutia-Fucugauchi, Takafumi Matsui, Kazuhisa Goto, Richard D Norris, Tamara J. Goldin, Pi Suhr Willumsen, José A. Arz, Wolf Uwe Reimold, Laia Alegret, Philippe Claeys, Christian Koeberl, Paul R. Bown, Alexander Deutsch, Mario Rebolledo-Vieyra, GeoZentrum Nordbayem, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Departamento de Ciencias de la Tierra, University of Zaragoza - Universidad de Zaragoza [Zaragoza], Department of Earth Sciences [Cambridge, UK], University of Cambridge [UK] (CAM), Department of Earth Sciences [UCL london], University College of London [London] (UCL), Department of Geosciences, Pennsylvania State University (Penn State), Penn State System-Penn State System, Institute of Geophysics [Austin] (IG), University of Texas at Austin [Austin], Earth System Science Group [Brussels] (ESSc), Vrije Universiteit Brussel (VUB), Planetary and Space Sciences Research Institute [Milton Keynes] (PSSRI), Centre for Earth, Planetary, Space and Astronomical Research [Milton Keynes] (CEPSAR), The Open University [Milton Keynes] (OU)-The Open University [Milton Keynes] (OU), Department of Earth Science and Engineering [Imperial College London], Imperial College London, Institut für Planetologie [Münster], Westfälische Wilhelms-Universität Münster (WWU), Department of Lithospheric Research [Wien], Universität Wien, Planetary Exploration Research Center [Chiba] (PERC), Chiba Institute of Technology (CIT), Instituto Mexicano del Petróleo (IMP), Earth Sciences Sector, Natural Resources Canada (NRCan), Research and Collections Division, Denver, Denver Museum of Nature and Science, Museum für Naturkunde [Berlin], Center for Lunar Science and Exploration [Houston], Lunar and Planetary Institute [Houston] (LPI), Department of Geological Sciences, University of Missouri [Columbia] (Mizzou), University of Missouri System-University of Missouri System, Earth and Atmospheric, Purdue University [West Lafayette], Osservatorio Geologico di Coldigioco (OGC), Department of Civil and Environmental Engineering and Earth Science [Notre Dame] (CEEES), University of Notre Dame [Indiana] (UND), SIO Geological, Scripps Institution of Oceanography, Planetary Science Institute [Tucson] (PSI), Department of Geology and Geophysics, University of Hawai‘i [Mānoa] (UHM), Unidad de Ciencias del Agua, Centro de Investigación Científica de Yucatán, Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Bruker Nano GmbH, Bruker Nano, Department of Earth and Environmental Sciences [Leuven] (EES), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Geological Survey of Canada [Calgary] (GSC Calgary), Geological Survey of Canada - Office (GSC), Natural Resources Canada (NRCan)-Natural Resources Canada (NRCan), Laboratorio de Paleomagnetismo de Paleomagnetismo y Paleoambientes, Universidad Nacional Autónoma de México (UNAM), Department of Earth and Ecosystem Sciences [Lund], Lund University [Lund], University of Alaska [Anchorage], Universität Erlangen, Université de Zaragoza, University of Cambridge [UK] ( CAM ), Department of Earth Sciences, University College of London [London] ( UCL ), PennState University [Pennsylvania] ( PSU ), Institute for Geophysics, Earth System Science, Vrije Universiteit [Brussel] ( VUB ), Planetary and Space Sciences Research Institute [Milton Keynes] ( PSSRI ), Centre for Earth, Planetary, Space and Astronomical Research [Milton Keynes] ( CEPSAR ), The Open University [Milton Keynes] ( OU ) -The Open University [Milton Keynes] ( OU ), Department of Earth Science and Engineering [London], Westfälische Wilhelms-Universität Münster ( WWU ), Planetary Exploration Research Center, Chiba Institute of Technology ( CIT ), Programa de Geología de Exploracíon y Explotacíon, Instituto Mexicano del Petroleo, Natural Resources Canada, Museum für Naturkunde, Humboldt Universität zu Berlin, Center for Lunar Science and Exploration, Lunar and Planetary Institute [Houston] ( LPI ), UNIVERSITY OF MISSOURI, Osservatorio Geologico di Coldigioco, Department of Civil Engineering and Geological Sciences, University of Notre Dame, Planetary Science Institute [Tucson] ( PSI ), University of Hawaii at Manoa ( UHM ), LAboratoire de Recherche en Mécanique Appliquée ( LARMAUR ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ( LSCE ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Centre National de la Recherche Scientifique ( CNRS ), Department of Earth and Environmental Sciences, Katholieke Universiteit Leuven ( KU Leuven ), Ressources Naturelles Canada, Universidad Nacional Autónoma de México ( UNAM ), Department of Earth and Ecosystem Sciences, University of Alaska, Penn State Department of Geosciences, Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Scripps Institution of Oceanography (SIO - UC San Diego), University of California [San Diego] (UC San Diego), University of California (UC)-University of California (UC)-University of California [San Diego] (UC San Diego), University of California (UC)-University of California (UC), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), and Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM)

Subjects
Extinction event, Sea level change, Multidisciplinary, Extinction, 010504 meteorology & atmospheric sciences, [SDE.MCG]Environmental Sciences/Global Changes, 010502 geochemistry & geophysics, 01 natural sciences, Cretaceous, Paleontology, [ SDE.MCG ] Environmental Sciences/Global Changes, Impact crater, Asteroid, [SDU.STU.CL]Sciences of the Universe [physics]/Earth Sciences/Climatology, Flood basalt, [ SDU.STU.CL ] Sciences of the Universe [physics]/Earth Sciences/Climatology, Geology, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences
Abstract

The Letters by Archibald et al. , Keller et al. , and Courtillot and Fluteau question our conclusion that the Cretaceous-Paleogene mass extinction was caused by the asteroid impact at Chicxulub. All three Letters stress that Deccan flood basalt volcanism played a major role in the extinction. Keller

Published
2010

22. An arsenic-driven pump for invisible gold in hydrothermal systems

Author

F. de Parseval, R. Pöttgen, Denis Testemale, Kalin Kouzmanov, D. Béziat, Marie-Christine Boiron, Maria A. Kokh, P. de Parseval, Gleb S. Pokrovski, M. Rovezzi, Olivier Proux, Thierry Aigouy, Marc Blanchard, Sophie Gouy, Stefano Salvi, Jean-Louis Hazemann, T. Doert, C. Escoda, T. Bartsch, L. Menjot, Géosciences Environnement Toulouse (GET), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Matériaux, Rayonnements, Structure (NEEL - MRS), Institut Néel (NEEL), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), University of Potsdam = Universität Potsdam, Centre de recherches sur la géologie des matières premières minérales et énergétiques (CREGU), Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France, Université de Genève = University of Geneva (UNIGE), Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Technische Universität Dresden = Dresden University of Technology (TU Dresden), Institut des Sciences de l'Univers of the Centre National de la Recherche ScientifiqueINSU-CNRS (CESSUR-OrPy-AsOrPy)Institut Carnot ISIFoR (OrPet)West African Exploration InitiativeWAXI-P934AFrench Grand Emprunt EquipExEcoX ANR-10-EQPX-27-01HPC resources from CALMIP2020-P1037French National Research Agency (ANR)ANR-2011-BlancSIMI-5-6-009CEA-CNRS CRG consortiumCentre National de la Recherche Scientifique (CNRS), ANR-16-CE31-0017,RADICALS,Les radicaux de soufre et leurs applications pour les ressources minérales, l'évolution des magmas et la géochimie isotopique(2016), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), Matériaux, Rayonnements, Structure (MRS), Universität Potsdam, Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Université de Genève (UNIGE), and Westfälische Wilhelms-Universität Münster (WWU)

Subjects
010504 meteorology & atmospheric sciences, chemistry.chemical_element, Geology, 010502 geochemistry & geophysics, 01 natural sciences, Hydrothermal circulation, chemistry, [SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistry, Geochemistry and Petrology, Environmental chemistry, Environmental Chemistry, Arsenic, [SDU.STU.MI]Sciences of the Universe [physics]/Earth Sciences/Mineralogy, 0105 earth and related environmental sciences
Abstract

International audience; Pyrite (FeS 2), arsenopyrite (FeAsS) and löllingite (FeAs 2) are exceptional gold concentrators on Earth; yet the exact redox and structural state of this "invisible" gold and the forces driving its intake and release by these minerals remain highly controversial. Here we applied high resolution X-ray absorption spectroscopy to Au-bearing pyrite and iron sulfarsenides from hydrothermal deposits and their synthetic analogues. We show that Au preferentially enters octahedral Fe structural sites [Au(As,S) 6 ] enriched in As, by forming respectively [AuAs 1-3 S 5-3 ], [AuAs 3 S 3 ⋯AuAs 6 ] and [AuAs 6 ] atomic units in arsenian pyrite (>0.1-1.0 wt. % As), arsenopyrite and löllingite, implying a formal oxidation state of Au II in the minerals. In contrast, in As-poor pyrite, Au is dominantly chemisorbed as [Au I S 2 ] moieties in much lower concentrations. Combined with experimental data on Au mineral-fluid partitioning, our findings imply a universal control exerted by arsenic on gold incorporation in iron sulfides and sulfarsenides via coupled Au-As redox reactions. These reactions account for the observed variations in invisible gold contents in the minerals from different hydrothermal deposit types and enable quantitative prediction of iron sulfarsenide ability in controlling gold concentration and distribution in hydrothermal systems.

Published
2021

23. Optimized one-step compression of femtosecond fibre laser soliton pulses around 1550nm to below 30 fs in highly nonlinear fibre

Author

Robert Fischer, Dragomir N. Neshev, John M. Dudley, François Courvoisier, Bertrand Kibler, R. Ferriere, Laurent Larger, Pierre-Ambroise Lacourt, Laboratoire Interdisciplinaire Carnot de Bourgogne ( LICB ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Physikalisches Institut [Münster], Westfälische Wilhelms-Universität Münster ( WWU ), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies ( FEMTO-ST ), Université de Technologie de Belfort-Montbeliard ( UTBM ) -Ecole Nationale Supérieure de Mécanique et des Microtechniques ( ENSMM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Nonlinear Physics Centre, Australian National University ( ANU ), Laboratoire Interdisciplinaire Carnot de Bourgogne (LICB), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Westfälische Wilhelms-Universität Münster (WWU), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), and Australian National University (ANU)

Subjects
Optical fiber, Materials science, genetic structures, Physics::Optics, 02 engineering and technology, 01 natural sciences, law.invention, 010309 optics, 020210 optoelectronics & photonics, Optics, law, Fiber laser, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, Electrical and Electronic Engineering, Frequency-resolved optical gating, business.industry, Nonlinear optics, equipment and supplies, eye diseases, Pulse (physics), Pulse compression, Femtosecond, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, Soliton, sense organs, [ SPI.OPTI ] Engineering Sciences [physics]/Optics / Photonic, business
Abstract

International audience; Optimised compression of femtosecond fibre laser pulses in highly nonlinear fibre is demonstrated. Specifically reported are compressed pulse durations below 30 fs using a simple setup where a single sub-10 cm segment of highly nonlinear fibre is directly spliced to the output pigtail of a commercial femtosecond fibre laser. The compressed pulse quality is confirmed through frequency resolved optical gating measurements.

Published
2007

24. Mass-independent and mass-dependent Cr isotopic composition of the Rumuruti (R) chondrites: Implications for their origin and planet formation

Author

Martin Schiller, Jean-Alix Barrat, Frédéric Moynier, Conel M. O'd. Alexander, Martin Bizzarro, Addi Bischoff, Ke Zhu, Institut de Physique du Globe de Paris (IPGP (UMR_7154)), Institut national des sciences de l'Univers (INSU - CNRS)-Université de La Réunion (UR)-Institut de Physique du Globe de Paris (IPG Paris)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre for Star and Planet Formation (STARPLAN), Globe Institute, Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH)-Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), Carnegie Institution for Science, Laboratoire des Sciences de l'Environnement Marin (LEMAR) (LEMAR), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Brest (UBO)-Institut Universitaire Européen de la Mer (IUEM), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut für Planetologie [Münster], Westfälische Wilhelms-Universität Münster = University of Münster (WWU), F. M. acknowledges funding from the European Research Council under the H2020 framework program/ERC grant agreement (ERC starting grant, #637503-PRISTINE) and financial support of the UnivEarthS Labex program at Université de Paris (#ANR-10-LABX-0023 and #ANR-11-IDEX-0005-02), and the IPGP platform PARI, and the Region Île-de-France Sesame grant no. 12015908. M. S. acknowledges funding from the Villum Fonden (#00025333). M. B. acknowledges funding from the Carlsberg Foundation (#CF18-1105), the Danish National Research Foundation (#DNRF97) and the European Research Council (ERC Advanced Grant Agreement, #833275-DEEPTIME). A. B. thanks the support by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation, #263649064) – TRR 170 (subproject B05). This is TRR170 Publication No. 116. K. Z. thanks the China Scholarship Council (CSC) for the PhD fellowship (#201706340161) and IPGP for the funding support of traveling, 'Aide à la MOBILITE INTERNATIONALE des doctorants de l’IPGP' (2019), to visit Earth and Planetary Laboratory, Carnegie Institution for Science., ANR-10-LABX-0023,UnivEarthS,Earth - Planets - Universe: observation, modeling, transfer(2010), ANR-11-IDEX-0005,USPC,Université Sorbonne Paris Cité(2011), European Project: 637503,H2020,ERC-2014-STG,PRISTINE(2015), Institut de Physique du Globe de Paris (IPGP), Institut national des sciences de l'Univers (INSU - CNRS)-IPG PARIS-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU)-Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Carnegie Institution for Science [Washington], Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), and Westfälische Wilhelms-Universität Münster (WWU)

Subjects
chondrules, cr-54, 010504 meteorology & atmospheric sciences, oxygen-isotope, Geochemistry, EARLY SOLAR-SYSTEM, earth, Ureilite, engineering.material, CHEMICAL-COMPOSITION, 010502 geochemistry & geophysics, 01 natural sciences, Cosmochemistry, CR-54, Geochemistry and Petrology, Chondrite, Cr stable isotopes, QUANTITATIVE MODELS, EARTH, fractionation, UBO, 0105 earth and related environmental sciences, Isotope, Chemistry, FRACTIONATION, ACL, METEORITE, Chondrule, Cr-54 nucleosynthetic anomalies, CHONDRULES, Rumuruti Chondrites, meteorite, OXYGEN-ISOTOPE, Mn-53-Cr-53 chronometry, Planetary science, 13. Climate action, DISCOVERY, Enstatite, engineering, Chondritic clast, quantitative models, chemical-composition, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, early solar-system, Planetary differentiation
Abstract

WOS:000600550100030; International audience; Chromium (Cr) isotopes play an important role in cosmochemistry and planetary science because they are powerful tools for dating (Mn-53-Cr-53 short-lived chronometry), tracing (Cr-54 nucleosynthetic anomalies) the origins of the materials, and studying the processes involved in volatile element fractionation and planetary differentiation (Cr stable isotopic fractionation). To use Cr isotopes for these purposes, it is essential to precisely know the compositions of the various chondritic reservoirs. However, the Cr isotope composition of Rumuruti (R) chondrites remains unknown. Here, we report high-precision mass-independent (average 2SE uncertainty of similar to 0.02 and similar to 0.06 for epsilon Cr-53 and epsilon Cr-54, respectively; epsilon indicates 10,000 deviation) and mass-dependent (uncertainty of average 0.03 parts per thousand for delta Cr-53; .delta indicates 1000 deviation) Cr isotope data for 12 bulk R chondrites of petrologic types 3-6 (including R chondrite breccias), and one R chondrite-like clast (MS-CH) in the Almahata Sitta polymict ureilite. All the R chondrites show homogeneous bulk epsilon Cr-54 values, -0.06 +/- 0.08 (2SD), similar only to those of the Earth-Moon system and enstatite chondrites. This first epsilon Cr-54 dataset for R chondrites provides significant addition to the epsilon Cr-54-A, Delta O-17 diagram, and positions them as a potential endmember for planetary precursors. The R chondrites possess a higher Mn-55/Cr-52 of 0.68 +/- 0.04 relative to most of carbonaceous chondrites and higher epsilon Cr-53 values 0.23 +/- 0.05 (2SD) relative to most of chondrite groups. This likely results from the lower chondrule abundance in R chondrites compared to that of ordinary and enstatite chondrites. The stable Cr isotope composition of R chondrites is homogeneous with a delta Cr-53 = -0.12 +/- 0.03%e (2SD). Combined with previous data of other groups of chondrites, we show that the stable Cr isotopic composition of all the chondrites is homogeneous with delta Cr-53 of -0.12 +/- 0.04%e (2SD, N = 42) and is independent of the petrologic type and redox conditions. The lack of mass-dependent fractionation between all groups of chondrites suggests that the average chondrite delta Cr-53 value is also representative for the initial composition of all differentiated planets in the Solar System. Finally, the MS-CH clast in Almahata Sitta has a Cr isotopic composition (epsilon Cr-53 = 0.18 +/- 0.04, epsilon Cr-54 = 0.16 +/- 0.07, and delta Cr-53 = -0.11 +/- 0.05%e) that is consistent (within error) with it being an R chondrite-like clast. (C) 2020 Elsevier Ltd. All rights reserved.

Published
2021

25. Names for trace fossils: a uniform approach

Author

George R. Demathieu, Michael Schlirf, Jan Kresten Nielsen, Simon J. Braddy, Alfred Uchman, Jorge F. Genise, Andrew K. Rindsberg, Kurt S. S. Nielsen, Richard G. Bromley, Markus Bertling, Radek Mikuláš, Geological and Palaeontological Institute, Westfälische Wilhelms-Universität Münster ( WWU ), School of Earth Sciences [Bristol], University of Bristol [Bristol], Geological Institute, Biogéosciences [Dijon] ( BGS ), AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), CONICET Museo Paleontolögico Egidio Feruglio, Consejo Nacional de Investigaciones Científicas y Técnicas ( CONICET ), Institute of Geology, Czech Academy of Sciences [Prague] ( ASCR ), Exploration and Production, Statoil A.S.A. [Norway], Geological Survey of Alabama, Institute for Palaeontology, Institute of Geological Sciences, Jagiellonian University [Krakow] ( UJ ), Grant (Be 1880/7-1) by the Deutsche Forschungsgemeinschaft, funding from Leverhulme Trust Grant F/82/AZ, from Grant Agency of the Czech Republic for financial support (Grant No. 205/04/0151), from the German Alexander-von-Humboldt-Stiftung, and from Julie von Rüllen Foundation (The Royal Danish Academy of Sciences and Letters)., Westfälische Wilhelms-Universität Münster (WWU), Geological Institute [Copenhagen], University of Copenhagen = Københavns Universitet (KU), Biogéosciences [UMR 6282] [Dijon] (BGS), Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Museo Paleontológico Egidio Feruglio [Chubut] (MEF), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET), Czech Academy of Sciences [Prague] (CAS), University of Alabama [Tuscaloosa] (UA), and Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ)

Subjects
Systematics, 010506 paleontology, ichnotaxobases, Ichnotaxa, Biology, Trace fossil, 010502 geochemistry & geophysics, 01 natural sciences, Paleontología, Ciencias de la Tierra y relacionadas con el Medio Ambiente, Sedimentary structures, Paleontology, Ichnology, ichnotaxa, Ichnotaxon, Rusophycus, ichnotaxonomy, Nomenclature, Ecology, Evolution, Behavior and Systematics, 0105 earth and related environmental sciences, [ SDU.STU.PG ] Sciences of the Universe [physics]/Earth Sciences/Paleontology, International Code of Zoological Nomenclature, 15. Life on land, nomenclature, [SDU.STU.PG]Sciences of the Universe [physics]/Earth Sciences/Paleontology, CIENCIAS NATURALES Y EXACTAS, trace fossils
Abstract

The taxonomic treatment of trace fossils needs a uniform approach, independent of the ethologic groups concerned. To this aim, trace fossils are rigorously defined with regard to biological taxa and physical sedimentary structures. Potential ichnotaxobases are evaluated, with morphology resulting as the most important criterion. For trace fossils related to bioerosion and herbivory, substrate plays a key role, as well as composition for coprolites. Size, producer, age, facies and preservation are rejected as ichnotaxobases. Separate names for undertracks and other poorly preserved material should gradually be replaced by ichnotaxa based on well-preserved specimens. Recent traces may be identified using established trace fossil taxa but new names can only be based on fossil material, even if the distinction between recent and fossil may frequently remain arbitrary. It is stressed that ichnotaxa must not be incorporated into biological taxa in systematics. Composite trace fossil structures (complex structures made by the combined activity of two or more species) have no ichnotaxonomic standing but compound traces (complex structures made by one individual tracemaker) may be named separately under certain provisions. The following emendations are proposed to the International Code of Zoological Nomenclature: The term ‘work of an animal’ should be deleted from the code, and ichnotaxa should be based solely on trace fossils as defined herein. Fil: Bertling, Markus. University of Münster. Geological and Palaeontological Institute; Alemania Fil: Braddy, Simon J.. University of Bristol. Department of Earth Sciences; Reino Unido Fil: Bromley, Richard G.. Geological Institute Copenhagen; Dinamarca Fil: Demathieu, George R.. University of Burgundy. Earth Sciences Centre; Francia Fil: Genise, Jorge Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "bernardino Rivadavia"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; Argentina Fil: Mikulás, Radek. Biology Centre of the Academy of Sciences of the Czech Republic; República Checa Fil: Nielsen, Jan K.. Statoil ASA. Exploration and Production; Noruega Fil: Nielsen, Kurt S. S.. Geological Institute Copenhagen; Dinamarca Fil: Rindsberg, Andrew K.. Geological Survey of Alabama; Estados Unidos Fil: Schlirf, Michael. Institute for Palaeontology; Alemania Fil: Uchman, Alfred. Jagiellonian University. Institute of Geological Sciences; Polonia

Published
2006

26. E-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow

Author

Cecilia Grimaldi, Jean-Christophe Olivo-Marin, Jan Schick, Jan Bandemer, Erez Raz, Aleix Boquet-Pujadas, Isabel Schumacher, Timo Betz, Anne Aalto, Bart Vos, Katsiaryna Tarbashevich, Zentrum für Molekularbiologie der Entzündung - Center for Molecular Biology of Inflammation [Münster, Germany] (ZMBE), Westfälische Wilhelms-Universität Münster (WWU), Analyse d'images biologiques - Biological Image Analysis (BIA), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU), This work was supported by the European Research Council (ERC, CellMig), the German Research Foundation (DFG, CRC 1348 and RA 863/11-1), The Medical Faculty of the University of Muenster and the Cells in Motion cluster. C.G. is a member of the CiM-IMPRS Graduate School. A.B.-P. is part of the Pasteur-Paris University (PPU) International PhD Programme, which received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 665807, and from the Institut Carnot Pasteur Microbes & Santé (ANR-16 CARN 0023-01). The BIA unit is partially supported by grants from the Labex IBEID (ANR-10-LABX-62-IBEID), France-BioImaging infrastructure (ANR-10-INBS-04), and the programme PIA INCEPTION (ANR-16-CONV-0005). T.B. and B.E.V. were supported by the European Research Council (Consolidator Grant 771201). Open Access funding enabled and organized by Projekt DEAL, ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-10-INBS-0004,France-BioImaging,Développment d'une infrastructure française distribuée coordonnée(2010), ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016), European Project: 268806,EC:FP7:ERC,ERC-2010-AdG_20100317,CELLMIG(2011), European Project: 665807,H2020,H2020-MSCA-COFUND-2014,PASTEURDOC(2015), Westfälische Wilhelms-Universität Münster = University of Münster (WWU), and Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, 0301 basic medicine, Embryology, [SDV]Life Sciences [q-bio], Cell, General Physics and Astronomy, MESH: Actomyosin, MESH: Cadherins, 0302 clinical medicine, Cell Movement, Adherens junctions, MESH: Animals, Pseudopodia, lcsh:Science, MESH: Cell Movement, Zebrafish, Multidisciplinary, biology, Chemistry, Actomyosin, Adhesion, Cadherins, Cell biology, medicine.anatomical_structure, Female, Leading edge, Cell type, Science, MESH: Zebrafish Proteins, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, MESH: Actins, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, medicine, Animals, Cell migration, MESH: Zebrafish, Actin, Cadherin, Front (oceanography), General Chemistry, Zebrafish Proteins, biology.organism_classification, Actins, MESH: Male, MESH: Germ Cells, Germ Cells, 030104 developmental biology, MESH: Pseudopodia, lcsh:Q, MESH: Female, 030217 neurology & neurosurgery
Abstract

The migration of many cell types relies on the formation of actomyosin-dependent protrusions called blebs, but the mechanisms responsible for focusing this kind of protrusive activity to the cell front are largely unknown. Here, we employ zebrafish primordial germ cells (PGCs) as a model to study the role of cell-cell adhesion in bleb-driven single-cell migration in vivo. Utilizing a range of genetic, reverse genetic and mathematical tools, we define a previously unknown role for E-cadherin in confining bleb-type protrusions to the leading edge of the cell. We show that E-cadherin-mediated frictional forces impede the backwards flow of actomyosin-rich structures that define the domain where protrusions are preferentially generated. In this way, E-cadherin confines the bleb-forming region to a restricted area at the cell front and reinforces the front-rear axis of migrating cells. Accordingly, when E-cadherin activity is reduced, the bleb-forming area expands, thus compromising the directional persistence of the cells., The arrival of migratory cells at their targets relies on following precise routes within tissues. Here the authors demonstrate that the cell adhesion molecule E-cadherin can control the path of cell migration by confining the site where bleb-type protrusions form within the cell front.

Published
2020

27. Enzymatic Construction of Artificial Base Pairs: The Effect of Metal Shielding

Author

Susanne Hensel, Fabienne Levi-Acobas, Marie Flamme, Jens Müller, Pascal Röthlisberger, Gilles Gasser, Shuvankar Naskar, Ivo Sarac, Marcel Hollenstein, Chimie bioorganique des acides nucléiques - Bioorganic chemistry of nucleic acids, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5), Westfälische Wilhelms-Universität Münster (WWU), Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL), Deutsche Forschungsgemeinschaft. Grant Number: SFB 858, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), and Westfälische Wilhelms-Universität Münster = University of Münster (WWU)

Subjects
Steric effects, synthesis, Base pair, DNA-Directed DNA Polymerase, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, Nucleobase, Metal, chemistry.chemical_compound, Coordination Complexes, [CHIM]Chemical Sciences, Nucleotide, Molecular Biology, chemistry.chemical_classification, Molecular Structure, [CHIM.ORGA]Chemical Sciences/Organic chemistry, 010405 organic chemistry, Chemistry, metal base pairs, Organic Chemistry, Imidazoles, DNA, Combinatorial chemistry, nucleotides, 0104 chemical sciences, visual_art, Nucleic acid, visual_art.visual_art_medium, Molecular Medicine, polymerases, expanded genetic alphabet, Copper, Systematic evolution of ligands by exponential enrichment
Abstract

International audience; Formation of metal base pairs is a versatile method for the introduction of metal cations into nucleic acids that has been applied in numerous applications including the construction of metal nanowires, development of energy, charge transfer devices and expansion of the genetic alphabet. As an alternative, enzymatic construction of metal base pairs represents an alluring strategy that grants access to longer sequences and offers the possibility of using such unnatural base pairs (UBPs) in SELEX experiments for the identification of functional nucleic acids. This method remains rather underexplored and a better understanding of the key parameters in the design of efficient nucleotides is required. Herein, we have investigated the effect of methylation of the imidazole nucleoside (dIm nMe TP) on the efficiency of the enzymatic construction of metal base pairs. The presence of methyl substituents on dImTP facilitates the polymerase-driven formation of dIm 4Me-Ag I-dIm and dIm 2Me TP-Cr III-dIm base pairs. Steric factors rather than basicity of the imidazole nucleobase appear to govern the enzymatic formation of such metal base pairs. We also demonstrate the compatibility of other metal cations rarely considered in the construction of artificial metal base with enzymatic DNA synthesis under both primer extension reaction and PCR conditions. These findings open up new directions for the design of nucleotide analogs for the development of metal base pairs. 2

Published
2020

28. A window in the course of alkaline magma differentiation conducive to immiscible REE-rich carbonatites

Author

Giada Iacono-Marziano, Malcolm Massuyeau, Emmanuel Le Trong, Ida Di Carlo, Johann Tuduri, Fabrice Gaillard, Laurent Bailly, Jérémie Melleton, Grégory Rogerie, Zineb Nabyl, Institut des Sciences de la Terre d'Orléans - UMR7327 (ISTO), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Observatoire des Sciences de l'Univers en région Centre (OSUC), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Magma - UMR7327, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Observatoire des Sciences de l'Univers en région Centre (OSUC), University of Johannesburg [South Africa] (UJ), Institut für Mineralogie, Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM), ANR-10-LABX-0100,VOLTAIRE,Geofluids and Volatil elements – Earth, Atmosphere, Interfaces – Resources and Environment(2010), European Project: 279790,EC:FP7:ERC,ERC-2011-StG_20101014,ELECTROLITH(2011), University of Johannesburg (UJ), and Westfälische Wilhelms-Universität Münster (WWU)

Subjects
Nephelinite, 010504 meteorology & atmospheric sciences, Geochemistry, 010502 geochemistry & geophysics, 01 natural sciences, Silicate, Cape verde, chemistry.chemical_compound, Igneous rock, chemistry, [SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistry, Geochemistry and Petrology, Magma, Carbonatite, Carbonate, Igneous differentiation, 0105 earth and related environmental sciences
Abstract

International audience; Rare earth element (REE) enrichments in carbonatites are often described as resulting from late magmatic-hydrothermal or supergene processes. However, magmatic pre-enrichment linked to the igneous processes at the origin of carbonatites are likely to contribute to the REE fertilisation. Experimental constraints reveals that immiscibility processes between carbonate and silicate melts can lead to both REE enrichments and depletions in carbonatites making the magmatic processes controlling REE enrichments unclear.We link REE contents of carbonatites to the magmatic stage at which carbonatites are separated from silicate magma in their course of differentiation. We present results of experiments made at pressure and temperature conditions of alkaline magmas and associated carbonatites differentiation (0.2 to 1.5 GPa; 725 to 975 °C; FMQ to FMQ +2.5), simultaneously addressing crystal fractionation of alkaline magmas and immiscibility between carbonate (calcio-carbonate type) and silicate melts (nephelinite to phonolite type). The experimental data shows that the degree of differentiation, controlling the chemical composition of alkaline melts, is a key factor ruling the REE concentration of the coexisting immiscible carbonate melts. In order to predict carbonate melt REE enrichments during alkaline magma differentiation, we performed a parameterisation of experimental data on immiscible silicate and carbonate melts, based exclusively on the silica content, the alumina saturation index and the alkali/alkaline-earth elements ratio of silicate melts. This parameterisation is applied to more than 1600 geochemical data of silicate magmas from various alkaline provinces (East African Rift, Canary and Cape Verde Islands) and show that REE concentrations of their potential coeval carbonatite melts can reach concentration ranges similar to those of highly REE enriched carbonatites (∑REE > 30 000 ppm) by immiscibility with phonolitic/phono-trachytic melt compositions, while more primitive alkaline magmas can only be immiscible with carbonatites that are not significantly enriched in REE.

Published
2020

29. Correlating sulfur solubility with short-to-intermediate-range ordering in the structure of borosilicate glasses

Author

Rajan Saini, Saurabh Kapoor, Daniel R. Neuville, Randall E. Youngman, Bianca M. Cerrutti, John S. McCloy, Hellmut Eckert, Ashutosh Goel, Rutgers, The State University of New Jersey [New Brunswick] (RU), Rutgers University System (Rutgers), Institut de Physique du Globe de Paris (IPGP), Institut national des sciences de l'Univers (INSU - CNRS)-IPG PARIS-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Westfälische Wilhelms-Universität Münster (WWU), Washington State University (WSU), and Universidade de São Paulo (USP)

Subjects
nuclear waste, VIDRO, 02 engineering and technology, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, Borosilicate glass, MAS NMR spectroscopy, General Energy, ICP– OES, 0103 physical sciences, Raman spectroscopy, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], Physical and Theoretical Chemistry, 010306 general physics, 0210 nano-technology
Abstract

International audience; The present study focuses on understanding the structural dependence of sulfur (as SO3) solubility in Na2O–B2O3–SiO2 glasses over a broad composition space exhibiting a rich variety of structural associations. The focus is on probing the impact of the (1) structural role of Na+, (2) degree of polymerization, and (3) network former connectivity (formation of Si–O–B and B–O–B linkages) on sulfur solubility in borosilicate glasses. By employing a suite of state-of-the-art characterization techniques, including inductively coupled plasma-optical emission spectroscopy (ICP-OES), magic-angle spinning (MAS) NMR spectroscopy, and Raman spectroscopy, an inverse correlation has been established between the sulfur solubility and the degree of network polymerization in the glasses across the investigated composition space. While the modification of SO3 leading to the formation of SO42– can successfully compete with the network depolymerization mechanisms (i.e., creation of nonbridging oxygens) and induce repolymerization in the glass network, the BO3 → BO4 conversion facilitated by the charge compensation by alkali cations takes precedence. The results from this study, when extended to more complex borosilicate-based glass compositions, will not only add to our understanding of the fundamental science controlling the sulfur solubility in borosilicate-based real-world nuclear waste glasses but will also form a basis for the development of nonempirical quantitative structure–property relationship (QSPR)-based predictive models.

Published
2022

30. BepiColombo - Mission Overview and Science Goals

Author

Benkhoff, Johannes, Murakami, Go, Baumjohann, W., Besse, S., Bunce, E.J., Casale, Mauro, Cremonese, G., Glassmeier, K. H., Hayakawa, H., Heyner, Daniel, Hiesinger, H., Huovelin, Juhani, Hussmann, H., Iafolla, V., Iess, Luciano, Kasaba, Yasumasa, Kobayashi, Masanori, Milillo, Anna, Mitrofanov, Igor G., Montagnon, Elsa, Novara, M., Orsini, Stefano, Quemerais, Eric, Reininghaus, U., Saito, Yoshifumi, Santoli, Francesco, Stramaccioni, D., Sutherland, O., Thomas, N., Yoshikawa, I., Zender, Joe, Department of Physics, European Space Research and Technology Centre (ESTEC), European Space Agency (ESA), Japan Aerospace Exploration Agency [Sagamihara] (JAXA), Space Research Institute of Austrian Academy of Sciences (IWF), Austrian Academy of Sciences (OeAW), European Space Astronomy Centre (ESAC), School of Physics and Astronomy [Leicester], University of Leicester, INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), Institut für Geophysik und Extraterrestrische Physik [Braunschweig] (IGEP), Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], Institute of Space and Astronautical Science (ISAS), Institut für Planetologie [Münster], Westfälische Wilhelms-Universität Münster (WWU), Department of Physics [Helsinki], Falculty of Science [Helsinki], University of Helsinki-University of Helsinki, DLR Institut für Planetenforschung, Deutsches Zentrum für Luft- und Raumfahrt [Berlin] (DLR), Istituto di Astrofisica e Planetologia Spaziali - INAF (IAPS), Dipartimento di Ingegneria Meccanica e Aerospaziale [Roma La Sapienza] (DIMA), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Planetary Plasma and Atmospheric Research Center [Sendai] (PPARC), Tohoku University [Sendai], Planetary Exploration Research Center [Chiba] (PERC), Chiba Institute of Technology (CIT), Space Research Institute of the Russian Academy of Sciences (IKI), Russian Academy of Sciences [Moscow] (RAS), European Space Operations Center (ESOC), HELIOS - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Physikalisches Institut [Bern], Universität Bern [Bern], Department of Complexity Science and Engineering [Tokyo], and The University of Tokyo (UTokyo)

Subjects
SURFACE, 010504 meteorology & atmospheric sciences, BepiColombo, Scientific Space Mission, Missions, 114 Physical sciences, 01 natural sciences, MAGNETOSPHERE, Planetary and Magnetospheric Science, 0103 physical sciences, MESSENGER OBSERVATIONS, SPECTROMETER, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, MERCURY ORBITER MISSION, Mercury exploration, 520 Astronomy, Science Goals, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy and Astrophysics, Mercury, 620 Engineering, CORNERSTONE MISSION, Surface and Interior, GAMMA-RAY, [SDU]Sciences of the Universe [physics], POLAR DEPOSITS, Space and Planetary Science, Fundamental Physics, Physics::Space Physics, Astrophysics::Earth and Planetary Astrophysics, VENUS, GENERATION
Abstract

BepiColombo is a joint mission between the European Space Agency, ESA, and the Japanese Aerospace Exploration Agency, JAXA, to perform a comprehensive exploration of Mercury. Launched on $20^{\mathrm{th}}$ 20 th October 2018 from the European spaceport in Kourou, French Guiana, the spacecraft is now en route to Mercury.Two orbiters have been sent to Mercury and will be put into dedicated, polar orbits around the planet to study the planet and its environment. One orbiter, Mio, is provided by JAXA, and one orbiter, MPO, is provided by ESA. The scientific payload of both spacecraft will provide detailed information necessary to understand the origin and evolution of the planet itself and its surrounding environment. Mercury is the planet closest to the Sun, the only terrestrial planet besides Earth with a self-sustained magnetic field, and the smallest planet in our Solar System. It is a key planet for understanding the evolutionary history of our Solar System and therefore also for the question of how the Earth and our Planetary System were formed.The scientific objectives focus on a global characterization of Mercury through the investigation of its interior, surface, exosphere, and magnetosphere. In addition, instrumentation onboard BepiColombo will be used to test Einstein’s theory of general relativity. Major effort was put into optimizing the scientific return of the mission by defining a payload such that individual measurements can be interrelated and complement each other.

Published
2021

31. Face Processing in Developmental Prosopagnosia: Altered Neural Representations in the Fusiform Face Area

Author

Alexa Haeger, Christophe Pouzat, Volker Luecken, Karim N’Diaye, Christian Elger, Ingo Kennerknecht, Nikolai Axmacher, Vera Dinkelacker, JARA-BRAIN [Aix-la-Chapelle, Allemagne], Jülich Aachen Research Alliance (JARA), Forschungszentrum Jülich GmbH | Centre de recherche de Juliers, Helmholtz-Gemeinschaft = Helmholtz Association, RWTH Aachen University, Mathématiques Appliquées Paris 5 (MAP5 - UMR 8145), Institut National des Sciences Mathématiques et de leurs Interactions (INSMI)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Recherche Mathématique Avancée (IRMA), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), BetaKlinik, Westfälische Wilhelms-Universität Münster (WWU), Ruhr-Universität Bochum [Bochum], Hôpital de Hautepierre [Strasbourg], Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
Brain activity and meditation, Cognitive Neuroscience, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Population, Neurosciences. Biological psychiatry. Neuropsychiatry, perception, 050105 experimental psychology, working memory, fusiform face area (FFA), Correlation, 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, Encoding (memory), 0501 psychology and cognitive sciences, education, Original Research, education.field_of_study, [STAT.AP]Statistics [stat]/Applications [stat.AP], Working memory, Donsker’s random walk analysis, 05 social sciences, representational similarity analysis (RSA), Fusiform face area, prosopagnosia, Neuropsychology and Physiological Psychology, Neural coding, Psychology, 030217 neurology & neurosurgery, Cognitive psychology, Mental image, RC321-571, Neuroscience, face recognition
Abstract

Frontiers in behavioral neuroscience 15, 744466 (2021). doi:10.3389/fnbeh.2021.744466 special issue: "Individual and Social Behaviors / Edited by: Walter Adriani, Speciality Chief Editor; Nathaniel E. Anderson, Associate Editor; Ricardo Maria Arida, Associate Editor; Valerie J. Bolivar, Associate Editor", Published by Frontiers Research Foundation, Lausanne

Published
2021

32. Understanding Micropolar Theory in the Earth Sciences II: The Seismic Moment Tensor

Author

Abreu, Rafael, Durand, Stephanie, Institut für Geophysik, Westfälische Wilhelms-Universität Münster, Münster, Germany, Univ Lyon, UCBL, ENSL, UJM, CNRS, LGL-TPE, Villeurbanne, France, Westfälische Wilhelms-Universität Münster (WWU), Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement [Lyon] (LGL-TPE), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon), Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement (LGL-TPE), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Work (thermodynamics), 010504 meteorology & atmospheric sciences, Field (physics), Seismic moment tensor, Mathematical analysis, Moment tensor, Vertical axis, ddc:551.22, 010502 geochemistry & geophysics, 01 natural sciences, Physics::Geophysics, asymmetric moment tensor, Moment (mathematics), Geophysics, Geochemistry and Petrology, [SDU]Sciences of the Universe [physics], Kaikōura earthquake, micropolar theory, Seismogram, Geology, Seismology, 0105 earth and related environmental sciences, Block (data storage)
Abstract

Seismic events produced by block rotations about vertical axis occur in many geodynamic contexts. In this study, we show that these rotations can be accounted for using the proper theory, namely micropolar theory, and a new asymmetric moment tensor can be derived. We then apply this new theory to the Kaikōura earthquake (2016/11/14), Mw 7.8, one of the most complex earthquakes ever recorded with modern instrumental techniques. Using advanced numerical techniques, we compute synthetic seismograms including a full asymmetric moment tensor and we show that it induces measurable differences in the waveforms proving that seismic data can record the effects of the block rotations observed in the field. Therefore, the theory developed in this work provides a full framework for future dynamic source inversions of asymmetric moment tensors., Westfälische Wilhelms-Universität Münster (1056)

Published
2021

33. Destructive photon echo formation in six-wave mixing signals of a MoSe$_2$ monolayer

Author

Takashi Taniguchi, Tilmann Kuhn, Kenji Watanabe, Miroslav Bartos, Diana Vaclavkova, Paweł Machnikowski, Karol Nogajewski, Thilo Hahn, Marek Potemski, Jacek Kasprzak, Daniel Wigger, Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Laboratoire national des champs magnétiques intenses - Grenoble (LNCMI-G ), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), University of Warsaw (UW), National Institute for Materials Science (NIMS), Politechnika Wroclawska [Wrocław], Nanophysique et Semiconducteurs (NPSC), Institut Néel (NEEL), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), University of Münster, Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Westfälische Wilhelms-Universität Münster (WWU), Centre National de la Recherche Scientifique (CNRS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), and Université Grenoble Alpes (UGA)-Université Grenoble Alpes (UGA)

Subjects
Materials science, Photon, Science, General Chemical Engineering, Exciton, FOS: Physical sciences, General Physics and Astronomy, Medicine (miscellaneous), Physics::Optics, 02 engineering and technology, 01 natural sciences, Biochemistry, Genetics and Molecular Biology (miscellaneous), Molecular physics, law.invention, law, Mesoscale and Nanoscale Physics (cond-mat.mes-hall), 0103 physical sciences, Monolayer, General Materials Science, 010306 general physics, Spectroscopy, Local field, Mixing (physics), Condensed Matter - Mesoscale and Nanoscale Physics, transition metal dichalcogenides, General Engineering, photon echo, 021001 nanoscience & nanotechnology, Laser, nonlinear spectroscopy, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], 0210 nano-technology, Ultrashort pulse, Optics (physics.optics), Physics - Optics
Abstract

Monolayers of transition metal dichalcogenides display a strong excitonic optical response. Additionally encapsulating the monolayer with hexagonal boron nitride allows to reach the limit of a purely homogeneously broadened exciton system. On such a MoSe2‐based system, ultrafast six‐wave mixing spectroscopy is performed and a novel destructive photon echo effect is found. This process manifests as a characteristic depression of the nonlinear signal dynamics when scanning the delay between the applied laser pulses. By theoretically describing the process within a local field model, an excellent agreement with the experiment is reached. An effective Bloch vector representation is developed and thereby it is demonstrated that the destructive photon echo stems from a destructive interference of successive repetitions of the heterodyning experiment.

Published
2021

34. Brain inflammation triggers macrophage invasion across the blood-brain barrier in Drosophila during pupal stages

Author

Billel Benmimoun, Dominik Funke, Simone Rey, Bente Winkler, Christian Klämbt, Mary A. Logan, Pauline Spéder, Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Plasticité cérébrale en Réponse à l'Environnement / Brain Plasticity In Response To The Environment, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Oregon Health and Science University [Portland] (OHSU), This work was supported by an H. Hertz fellowship to B.W., the German research foundation (DFG SFB 1009) to C.K., and a starting package from Institut Pasteur/LabEx Revive to P.S., We are indebted to D. Siekhaus, K. Brückner, B. Lemaitre, S. Schirmeier, and N. Pogodalla for sharing many fly strains. We are thankful to D. Briand for help during GBS infection and to L. Krift for help during the transplantation experiments. We are thankful to T. Zobel for help with macrophage counting and J. Stewen for help with the qPCR. We thank S. Rumpf and members of the Klämbt lab for critical reading of the manuscript and help throughout the project., ANR-17-CE13-0018,NeuraSteNic,Interactions entre les cellules souches neurales et leur niche lors de la neurogenèse chez la drosophile(2017), Westfälische Wilhelms-Universität Münster (WWU), and Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)

Subjects
Nervous system, [SDV]Life Sciences [q-bio], media_common.quotation_subject, Phagocytosis, Central nervous system, Immunology, Inflammation, Biology, Blood–brain barrier, 03 medical and health sciences, 0302 clinical medicine, Immune system, medicine, Pathogen, 030304 developmental biology, media_common, 0303 health sciences, Multidisciplinary, fungi, Longevity, SciAdv r-articles, 3. Good health, Cell biology, medicine.anatomical_structure, Cellular Neuroscience, Biomedicine and Life Sciences, medicine.symptom, 030217 neurology & neurosurgery, Research Article
Abstract

Description, Macrophages can invade the fly brain triggered by inflammation and show phagocytotic responses reducing longevity., The nervous system is shielded from circulating immune cells by the blood-brain barrier (BBB). During infections and autoimmune diseases, macrophages can enter the brain where they participate in pathogen elimination but can also cause tissue damage. Here, we establish a Drosophila model to study macrophage invasion into the inflamed brain. We show that the immune deficiency (Imd) pathway, but not the Toll pathway, is responsible for attraction and invasion of hemolymph-borne macrophages across the BBB during pupal stages. Macrophage recruitment is mediated by glial, but not neuronal, induction of the Imd pathway through expression of Pvf2. Within the brain, macrophages can phagocytose synaptic material and reduce locomotor abilities and longevity. Similarly, we show that central nervous system infection by group B Streptococcus elicits macrophage recruitment in an Imd-dependent manner. This suggests that evolutionarily conserved inflammatory responses require a delicate balance between beneficial and detrimental activities.

Published
2021

35. Experimental investigation of Ru isotope fractionation between metal, silicate and sulfide melts

Author

Tobias Grützner, Timo Hopp, Jasper Berndt, Arno Rohrbach, Stephan Klemme, Institut de minéralogie, de physique des matériaux et de cosmochimie (IMPMC), Muséum national d'Histoire naturelle (MNHN)-Institut de recherche pour le développement [IRD] : UR206-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Westfälische Wilhelms-Universität Münster = University of Münster (WWU), University of Chicago, and Westfälische Wilhelms-Universität Münster (WWU)

Subjects
010504 meteorology & atmospheric sciences, Sulfide, Analytical chemistry, chemistry.chemical_element, Fractionation, 010502 geochemistry & geophysics, 7. Clean energy, 01 natural sciences, Ruthenium, Metal, chemistry.chemical_compound, Isotope fractionation, Geochemistry and Petrology, [SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistry, High pressure-high temperature experiments, 0105 earth and related environmental sciences, chemistry.chemical_classification, Isotope, Geology, Sulfur, Silicate, chemistry, 13. Climate action, visual_art, Core formation, visual_art.visual_art_medium, Stable isotope fractionation, Highly siderophile elements, Tin
Abstract

International audience; To improve the understanding of large-scale planetary processes, i.e. differentiation and core formation, of Earth and other planetary bodies, we performed experiments at 1 GPa in a range of 2 temperatures to investigate mass-dependent isotope fractionation of ruthenium (Ru) between metal, silicate, and sulfide melts. Metal silicate fractionation is Ru/ 99 Rusilicate-102 Ru/ 99 Rumetal = 0.02 ± 0.02 ‰ (95% confidence interval) at °C and therefore negligible for Earth's core formation. However, there is resolvable Ru isotope fractionation between liquid metal and liquid sulfide: The 102 Ru/ 99 Ru ratio of liquid sulfide is 0.11 ± 0.03 ‰ lighter than that of liquid metal at 1400 °C in sulfur (S)-bearing experiments. The unexpected lighter Ru isotope composition of the sulfide can be best explained with different Ru-S bonding environments. Our results show furthermore, that addition of tin (Sn) instead of S to experimental charges affects Ru isotope fractionation significantly. The 102 Ru/ 99 Ru ratios in the Sn-bearing phase are 0.18 ‰ ± 0.01 ‰ heavier than metal; hence, the presence of Sn not only changes the magnitude of the Ru isotope fractionation but also its direction. The observed Ru isotope fractionations are too small to preserve a resolvable isotope fractionation signature during core formation or the Hadean matte scenario at very high temperatures.

Published
2021

36. The Often-Overlooked Power of Summary Statistics in Exploratory Data Analysis: Comparison of Pattern Recognition Entropy (PRE) to Other Summary Statistics and Introduction of Divided Spectrum-PRE (DS-PRE)

Author

Tahereh G. Avval, Vincent Fernandez, Emily F. Smith, Matthew R. Linford, Neal B. Gallagher, Bonnie J. Tyler, Behnam Moeini, Victoria Carver, Neal Fairley, Jonas Baltrusaitis, Brigham Young University (BYU), Casa Software Ltd, University of Nottingham, UK (UON), Lehigh University [Bethlehem], Institut des Matériaux Jean Rouxel (IMN), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Ecole Polytechnique de l'Université de Nantes (EPUN), Université de Nantes (UN)-Université de Nantes (UN), Westfälische Wilhelms-Universität Münster (WWU), and Eigenvector Res Inc

Subjects
Computer science, General Chemical Engineering, Entropy, 02 engineering and technology, Library and Information Sciences, 01 natural sciences, Cluster Analysis, Entropy (energy dispersal), Least-Squares Analysis, Cluster analysis, ComputingMilieux_MISCELLANEOUS, Principal Component Analysis, business.industry, 010401 analytical chemistry, Explained sum of squares, Pattern recognition, General Chemistry, 021001 nanoscience & nanotechnology, Summary statistics, 0104 chemical sciences, Computer Science Applications, Data set, Exploratory data analysis, Pattern recognition (psychology), Principal component analysis, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], Artificial intelligence, 0210 nano-technology, business, Algorithms
Abstract

Unsupervised exploratory data analysis (EDA) is often the first step in understanding complex data sets. While summary statistics are among the most efficient and convenient tools for exploring and describing sets of data, they are often overlooked in EDA. In this paper, we show multiple case studies that compare the performance, including clustering, of a series of summary statistics in EDA. The summary statistics considered here are pattern recognition entropy (PRE), the mean, standard deviation (STD), 1-norm, range, sum of squares (SSQ), and X4, which are compared with principal component analysis (PCA), multivariate curve resolution (MCR), and/or cluster analysis. PRE and the other summary statistics are direct methods for analyzing data-they are not factor-based approaches. To quantify the performance of summary statistics, we use the concept of the "critical pair," which is employed in chromatography. The data analyzed here come from different analytical methods. Hyperspectral images, including one of a biological material, are also analyzed. In general, PRE outperforms the other summary statistics, especially in image analysis, although a suite of summary statistics is useful in exploring complex data sets. While PRE results were generally comparable to those from PCA and MCR, PRE is easier to apply. For example, there is no need to determine the number of factors that describe a data set. Finally, we introduce the concept of divided spectrum-PRE (DS-PRE) as a new EDA method. DS-PRE increases the discrimination power of PRE. We also show that DS-PRE can be used to provide the inputs for the k-nearest neighbor (kNN) algorithm. We recommend PRE and DS-PRE as rapid new tools for unsupervised EDA.

Published
2021

37. CRYSTALLINITY OF THE HOMOGENIZED ENERGY DENSITY OF PERIODIC LATTICE SYSTEMS

Author

Antonin Chambolle, Leonard Kreutz, CEntre de REcherches en MAthématiques de la DEcision (CEREMADE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Fachbereich Mathematik und Informatik [Münster] = Fachbereich Mathematik und Informatik [Münster] (FB 10), and Westfälische Wilhelms-Universität Münster (WWU)

Subjects
Statistical Mechanics (cond-mat.stat-mech), Ecological Modeling, MSC 2010: 35B27, 49J45, 82B20, 82D40, FOS: Physical sciences, General Physics and Astronomy, Wulff Shape, Mathematical Physics (math-ph), General Chemistry, Computer Science Applications, Γ-convergence, Modeling and Simulation, Ising system, Crystallinity, Mathematical Physics, Condensed Matter - Statistical Mechanics, [MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA]
Abstract

We study the homogenized energy densities of periodic ferromagnetic Ising systems. We prove that, for finite range interactions, the homogenized energy density, identifying the effective limit, is crystalline, i.e. its Wulff crystal is a polytope, for which we can (exponentially) bound the number of vertices. This is achieved by deriving a dual representation of the energy density through a finite cell formula. This formula also allows easy numerical computations: we show a few experiments where we compute periodic patterns which minimize the anisotropy of the surface tension.

Published
2021

38. Deep carbon cycle constrained by carbonate solubility

Author

Mohamed Mezouar, Stefan Farsang, Remo N. Widmer, Simon A. T. Redfern, Angelika Dorothea Rosa, Xiaolei Feng, Chaoshuai Zhao, Jin Liu, Marion Louvel, Farsang, Stefan [0000-0002-4918-5566], Mezouar, Mohamed [0000-0001-5336-544X], Rosa, Angelika D [0000-0002-2304-1943], Widmer, Remo N [0000-0001-7664-4791], Feng, Xiaolei [0000-0003-4410-4576], Liu, Jin [0000-0002-1670-8199], Redfern, Simon AT [0000-0001-9513-0147], Apollo - University of Cambridge Repository, Redfern, Simon A T [0000-0001-9513-0147], Department of Earth Sciences, University of Cambridge, University of Cambridge [UK] (CAM), Institut für Mineralogie-Münster, Westfälische Wilhelms-Universität Münster (WWU), Center for High Pressure Science & Technology Advanced Research (HPSTAR), European Synchrotron Radiation Facility (ESRF), Swiss Federal Laboratories for Materials Science and Technology (EMPA), Asian School of the Environment (ASE), Nanyang Technological University [Singapour], Rosa, Angelika D. [0000-0002-2304-1943], Widmer, Remo N. [0000-0001-7664-4791], and Redfern, Simon A. T. [0000-0001-9513-0147]

Subjects
Rhodochrosite, 010504 meteorology & atmospheric sciences, Science, General Physics and Astronomy, Mineralogy, chemistry.chemical_element, 010502 geochemistry & geophysics, 01 natural sciences, General Biochemistry, Genetics and Molecular Biology, Article, Carbon cycle, chemistry.chemical_compound, [SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistry, Solubility, Dissolution, 0105 earth and related environmental sciences, 13 Climate Action, Multidisciplinary, General Chemistry, 704/2151/330, Geochemistry, chemistry, 13. Climate action, Slab, Carbonate, 704/2151/209, Carbon, Magnesite
Abstract

Earth’s deep carbon cycle affects atmospheric CO2, climate, and habitability. Owing to the extreme solubility of CaCO3, aqueous fluids released from the subducting slab could extract all carbon from the slab. However, recycling efficiency is estimated at only around 40%. Data from carbonate inclusions, petrology, and Mg isotope systematics indicate Ca2+ in carbonates is replaced by Mg2+ and other cations during subduction. Here we determined the solubility of dolomite [CaMg(CO3)2] and rhodochrosite (MnCO3), and put an upper limit on that of magnesite (MgCO3) under subduction zone conditions. Solubility decreases at least two orders of magnitude as carbonates become Mg-rich. This decreased solubility, coupled with heterogeneity of carbon and water subduction, may explain discrepancies in carbon recycling estimates. Over a range of slab settings, we find aqueous dissolution responsible for mobilizing 10 to 92% of slab carbon. Globally, aqueous fluids mobilise \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${35}_{-17}^{+20}$$\end{document}35−17+20% (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${27}_{-13}^{+16}$$\end{document}27−13+16 Mt/yr) of subducted carbon from subducting slabs., Carbonate mineral aqueous solubility decreases as carbonates become more Mg-rich during subduction. Coupled with regional variations in amounts of carbon and water subducted, this explains discrepancies in estimates of carbon recycling, suggesting that only around a third returns to the surface.

Published
2021

39. Intense biogeochemical iron cycling revealed in Neoarchean micropyrites from stromatolites

Author

Johanna Marin-Carbonne, Christophe Thomazo, Nicolas Olivier, Marie-Noëlle Decraene, Pascal Philippot, Etienne Deloule, Harald Strauss, Institut des sciences de la terre [Lausanne] (ISTE), Université de Lausanne (UNIL), Centre de Recherches Pétrographiques et Géochimiques (CRPG), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Biogéosciences [UMR 6282] [Dijon] (BGS), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Laboratoire Magmas et Volcans (LMV), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement et la société-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Géosciences Montpellier, Institut national des sciences de l'Univers (INSU - CNRS)-Université de Montpellier (UM)-Université des Antilles (UA)-Centre National de la Recherche Scientifique (CNRS), University of São Paulo (USP), Westfälische Wilhelms-Universität Münster (WWU), Université de Lausanne = University of Lausanne (UNIL), Biogéosciences [UMR 6282] (BGS), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Universidade de São Paulo = University of São Paulo (USP), and Westfälische Wilhelms-Universität Münster = University of Münster (WWU)

Subjects
Biogeochemical cycle, 010504 meteorology & atmospheric sciences, Archean, Geochemistry, engineering.material, Iron respiration, 010502 geochemistry & geophysics, 01 natural sciences, Early life, Sedimentary depositional environment, δ34S, Stromatolites, [SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistry, Geochemistry and Petrology, 14. Life underwater, Microbial mat, 0105 earth and related environmental sciences, Chemistry, Iron isotopes, Ion microprobe, Diagenesis, Tumbiana Formation, 13. Climate action, engineering, Sedimentary rock, Pyrite
Abstract

International audience; Iron isotope compositions of sedimentary pyrites (FeS2) are used to constrain the redox evolution of the Precambrian ocean and early Fe-based metabolisms such as Dissimilatory Iron Reduction (DIR). Sedimentary pyrites can record biotic and abiotic iron reduction, which have similar ranges of Fe isotopic fractionation, as well as post-depositional histories and metamorphic overprints that can modify Fe isotope compositions. However, some exceptionally well-preserved sedimentary records, such as the stromatolite-bearing Tumbiana Formation (ca. 2.7 Ga, Western Australia) have been proven to retain primary information on Early Neoarchean microbial ecosystems and associated metabolic pathways. Here, we present in situ Fe isotope measurements of micropyrites included in four stromatolites from the Tumbiana Formation in order to assess iron respiration metabolism using Fe isotope signatures. A set of 142 micropyrites has been analyzed in three lamina types, i.e. micritic, organic-rich and fenestral laminae, by Secondary Ion Mass Spectrometry (SIMS), using a Hyperion radio-frequency plasma source. The diversity of laminae is attributed to specific depositional environments, leading to the formation of Type 1 (micritic laminae) and Type 2 (organic-rich laminae) and early diagenetic effects (Type 3, fenestral laminae). Type 1 and 2 laminae preserved comparable δ56Fe ranges, respectively from −1.76‰ to +4.15‰ and from −1.54‰ to +4.44‰. Type 3 laminae recorded a similar range, although slightly more negative δ56Fe values between −2.20‰ and +2.65‰. Globally, our data show a large range of δ56Fe values, from −2.20‰ to +4.44‰, with a unimodal distribution that differs from the bimodal distribution previously reported in the Tumbiana stromatolites. Such a large range and unimodal distribution cannot be explained by a unique process (e.g., biotic/abiotic Fe reduction or pyrite formation only controlled by the precipitation rate). It rather could reflect a two-step iron cycling process in the sediment pore water including i) partial Fe oxidation forming Fe(OH)3 with positive δ56Fe values followed by ii) partial, possibly microbially induced, Fe reduction leading to Fe2+ availability for pyrite formation by sulfate reducers carrying both negative δ56Fe and δ34S signatures. In this model, the buildup and subsequent reduction through time of a residual Fe(OH)3 reservoir arising from the activity of methanotrophs, can explain the strongly positive δ56FeFe(OH)3 values up to 4‰. These results indicate that Archean microbial mats have been the site of the interaction of several closely linked biogeochemical cycles involving Fe, S and C.

Published
2021

40. Silicate melt inclusions in the new millennium: A review of recommended practices for preparation, analysis, and data presentation

Author

M. E. Newcombe, D. J. Rasmussen, Alexander R. L. Nichols, Matthew Jones, Oded Navon, Graham D. Layne, M. Myers, Horst R. Marschall, C. M. Allison, A. Lorenzo-Merino, K. Shimizu, Federica Schiavi, Mark D. Kurz, A. Daly, Ping-Ping Liu, A. Barth, Margaret E. Hartley, Nivea Magalhães, Yuxu Zhang, Roger L. Nielsen, Terry Plank, Janne M. Koornneef, Alexander A. Iveson, K.-Y. Lin, M. Laubier, T. Zhou, Charlotte L. DeVitre, Jordan Tucker, Glenn A. Gaetani, Yves Moussallam, M. Gaborieau, Masataka Kawaguchi, N. Luciani, Nobumichi Shimizu, Ayla S. Pamukcu, T. Kagoshima, Elizabeth Cottrell, A. Castillejo, J. Andrys, Robert J. Bodnar, Ery C. Hughes, B. Chilson-Parks, D. Butters, J. Roberge, M. Cole, Anne-Sophie Bouvier, M. Muth, Yaron Katzir, Emma Gatti, B.R. Choudhary, Felix S. Genske, Diego Narváez, A. H. Lerner, Mélissa J. Drignon, Jay B. Thomas, C. Waelkens, L. Moore, G. T. Thompson, Gokce Ustunisik, Tatsuhiko Kawamoto, B. D. Monteleone, E Johnson, A.J.J. Bracco Gartner, Katherine A. Kelley, Michael O. Garcia, D. M. Schwartz, Nicolas Cluzel, Paul J. Wallace, C.A. Angeles de la Torre, Leonid V. Danyushevsky, Estelle Rose-Koga, Peter J. Michael, Laboratoire Magmas et Volcans (LMV), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement et la société-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut des sciences de la terre [Lausanne] (ISTE), Université de Lausanne (UNIL), Woods Hole Oceanographic Institution (WHOI), Department of Earth Sciences [Eugene OR], University of Oregon [Eugene], Cornell University [New York], Graduate School of Oceanography [Narragansett], University of Rhode Island (URI), Instituto Politecnico Nacional [Mexico] (IPN), Lamont-Doherty Earth Observatory (LDEO), Columbia University [New York], Department of Geosciences [Blacksburg], Virginia Tech [Blacksburg], Vrije Universiteit Amsterdam [Amsterdam] (VU), School of Earth Sciences [Bristol], University of Bristol [Bristol], Brown University, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, University of Connecticut (UCONN), New Mexico State University, Smithsonian Institution, School of Earth Sciences [Hobart], University of Tasmania [Hobart, Australia] (UTAS), College of Earth, Ocean and Atmospheric Sciences [Corvallis] (CEOAS), Oregon State University (OSU), Centre de Recherches Pétrographiques et Géochimiques (CRPG), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Department of Geology and Geophysics [Mānoa], University of Hawai‘i [Mānoa] (UHM), California Institute of Technology (CALTECH), Westfälische Wilhelms-Universität Münster (WWU), University of Manchester [Manchester], Department of Earth Sciences [Durham], Durham University, The University of Tokyo (UTokyo), Ben-Gurion University of the Negev (BGU), Kumamoto University, University of Shizuoka, Memorial University of Newfoundland [St. John's], University of Delaware [Newark], School of Earth and Space Sciences [Beijing], Peking University [Beijing], Instituto de Geofisica [Mexico], Universidad Nacional Autónoma de México (UNAM), University of Maryland [College Park], University of Maryland System, University of Toronto, Goethe-Universität Frankfurt am Main, University of Tulsa, Department of Earth Sciences [MSU Bozeman], Montana State University (MSU), Departamento de Geologia [Quito], Escuela Politécnica Nacional (EPN), The Hebrew University of Jerusalem (HUJ), University of Canterbury [Christchurch], South Dakota School of Mines and Technology (SDSM&T), American Museum of Natural History (AMNH), Boise State University, Carnegie Institution for Science [Washington], Kochi Institute for Core Sample Research, Japan Agency for Marine-Earth Science and Technology (JAMSTEC), Syracuse University, McGill University = Université McGill [Montréal, Canada], CAS Institute of Oceanology (IOCAS), Chinese Academy of Sciences [Beijing] (CAS), China University of Petroleum, ANR-10-LABX-0006,CLERVOLC,Clermont-Ferrand centre for research on volcanism(2010), ANR-16-IDEX-0001,CAP 20-25,CAP 20-25(2016), Université de Lausanne = University of Lausanne (UNIL), Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Memorial University of Newfoundland = Université Memorial de Terre-Neuve [St. John's, Canada] (MUN), Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), Carnegie Institution for Science, and Geology and Geochemistry

Subjects
010504 meteorology & atmospheric sciences, [SDU.STU.PE]Sciences of the Universe [physics]/Earth Sciences/Petrography, Library science, Geology, SDG 10 - Reduced Inequalities, 010502 geochemistry & geophysics, 01 natural sciences, Geochemistry and Petrology, [SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistry, In situ analysis, Data presentation, Inclusion (mineral), 0105 earth and related environmental sciences, Melt inclusions
Abstract

Mineral-hosted melt inclusions have become an important source of information on magmatic processes. As the number of melt inclusion studies increases, so does the need to establish recommended practice guidelines for collecting and reporting melt inclusion data. These guidelines are intended to ensure certain quality criteria are met and to achieve consistency among published melt inclusion data in order to maximize their utility in the future. Indeed, with the improvement of analytical techniques, new processes affecting melt inclusions are identified. It is thus critical to be able to reprocess any previously published data, such that reporting the raw data is one of the first “recommended practices” for authors and a publication-criteria that reviewers should be sensitive to. Our guidelines start with melt inclusion selection, which is a critical first step, and then continue on to melt inclusion preparation and analysis, covering the entire field of methods applicable to melt inclusions. Dedication In March of 2000, a melt inclusion workshop was held at the Chateau de Sassenage in Grenoble and a companion issue of Chemical Geology entitled “Melt Inclusions at the Millennium” was published. Erik Hauri was heavily involved with the meeting and contributed two landmark papers to the topical issue of Chemical Geology on the use of secondary ion mass spectrometry to analyze volatiles in melt inclusions. When the melt inclusion community re-convened at Woods Hole Oceanographic Institution (WHOI) in August of 2018, we were saddened that Erik was unable to join us due to his failing health. Less than a month later came the devastating news of his passing at only 52 years of age. In recognition of his incredible contributions to science in general and to the in situ analysis of melt inclusions in particular, the participants and organizers of the WHOI melt inclusion workshop dedicate this collegial paper to Erik Hauri, our colleague, mentor and friend. Thank you Erik.

Published
2021

41. Cultural metaphors and KMS appropriation: drawing on Astérix to understand non-use in a large French company

Author

Ewan Oiry, Aurélie Dudézert, Nathalie Mitev, Laboratoire en Innovation, Technologies, Economie et Management (EA 7363) (LITEM), Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Institut Mines-Télécom Business School (IMT-BS), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Département Technologies, Information & Management (TIM), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom Business School (IMT-BS), Institut Mines-Télécom [Paris] (IMT), Dauphine Recherches en Management (DRM), Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), European Research Center for Information Systems [Münster] (ERCIS), Westfälische Wilhelms-Universität Münster (WWU), Département de management et de technologie (ESG UQAM), Université du Québec à Montréal = University of Québec in Montréal (UQAM), CEntre de REcherche en GEstion - EA 1722 (CEREGE), Institut d'Administration des Entreprises (IAE) - Poitiers (IAE Poitiers), Université de Poitiers-Université de Poitiers-Université de Poitiers-Université de La Rochelle (ULR), LITEM-NPR, Département Technologies, Information & Management (IMT-BS - TIM), Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Université de Poitiers-Université de Poitiers-Université de Poitiers-La Rochelle Université (ULR), and Université de Poitiers-Université de Poitiers-Université de La Rochelle (ULR)-Université de Poitiers

Subjects
Organizational Behavior and Human Resource Management, Appropriation of knowledge, Astérix, Metaphor, media_common.quotation_subject, Knowledge management systems, 02 engineering and technology, Library and Information Sciences, Management Information Systems, Appropriation, 020204 information systems, Management of Technology and Innovation, Chief knowledge officers, 0502 economics and business, 0202 electrical engineering, electronic engineering, information engineering, Information system, Sociology, Action research, media_common, 05 social sciences, French organizations, Sensemaking, Epistemology, Action (philosophy), Information systems appropriation, Cultural metaphor, Management system, [SHS.GESTION]Humanities and Social Sciences/Business administration, 050203 business & management, Information Systems
Abstract

CNRS 2, FNEGE 2, HCERES A; International audience; Management research is increasingly using fiction as an insightful way to analyze complex organizational dynamics. Focusing on user appropriation of Knowledge Management Systems, we describe how we used the popular Astérix, a well-known French cartoon to better understand KMS appropriation. We came to use this approach in an action research project in a large French construction firm initially designed to help Chief Knowledge Officers address KMS non-use. After our first findings showed paradoxical cultural issues, and based on the idea that culture is central to sensemaking and appropriation, we used the notion of the cultural metaphor to help better understand the cultural aspects associated with KMS appropriation. These results contribute knowledge in three different areas. First, we underline the role of cultural metaphors in information systems appropriation. Second, we enrich the literature on the role of fiction in management by illustrating the role of cultural metaphors. Third, we report on how this can be used in an action research project to help better understand KMS appropriation issues, which has the potential of leading to practical managerial action.

Published
2021

42. Study of the structural transition and hydrogenation of CeTiGe

Author

Bernard Chevalier, Etienne Gaudin, Rainer Pöttgen, Tadhg Mahon, Sophie Tencé, Institut de Chimie de la Matière Condensée de Bordeaux (ICMCB), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut für Anorganische und Analytische Chemie, and Westfälische Wilhelms-Universität Münster (WWU)

Subjects
Neutron powder diffraction, hydrogen insertion, Materials science, Hydrogen, Intermetallic, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Materials Chemistry, Structural transition, intermetallics, Magnetic order, Hydride, Mechanical Engineering, Metals and Alloys, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, 3. Good health, Crystallography, chemistry, Mechanics of Materials, structural transition, magnetism, 0210 nano-technology
Abstract

There remains some disagreement in the literature on CeTiGe over the presence of a structural transition from the low temperature CeFeSi-type form to the high temperature CeScSi-type structure. We present a detailed study of the effect of temperature on this structural transition. Furthermore, the same hydride is obtained after hydrogenation of both forms. Using neutron powder diffraction we find that the structure of CeTiGeH 1.5 corresponds to a stuffed variant of the CeScSi-type structure with space group I 4 /mmm , a = 4.0785(1) A and c = 17.1060(8) A. The H atoms occupy both the Ce 4 tetrahedral sites and the Ti 4 Ce square based pyramidal sites for a total hydrogen occupancy of 1.5 H f.u. −1 . Preliminary examinations of the magnetic properties after hydrogenation reveal the onset of low temperature magnetic order around 3.5 K, suggesting for the first time a hydrogen induced magnetic order for an intermetallic with CeScSi-type structure.

Published
2019

43. Best practices for the use of meteorite names in publications

Author

Heck, Philipp R., Herd, Christopher, Grossman, Jeffrey N., Badjukov, Dmitry, Bouvier, Audrey, Bullock, Emma, Chennaoui-Aoudjehane, Hasnaa, Debaille, Vinciane, Dunn, Tasha L., Ebel, Denton S., Ferriere, Ludovic, Garvie, Laurence, Gattacceca, Jerome, Gounelle, Matthieu, Herd, Richard, Ireland, Trevor, Jacquet, Emmanuel, Macke, Robert J., McCoy, Tim, McCubbin, Francis M., Mikouchi, Takashi, Metzler, Knut, Roskosz, Mathieu, Smith, Caroline, Wadhwa, Meenakshi, Welzenbach-Fries, Linda, Yamaguchi, Akira, Zeigler, Ryan A., Zolensky, Michael, Yada, Toru, NASA Headquarters, Laboratoire de Sciences de la Terre (LST), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon), American Museum of Natural History, American Museum of Natural History (AMNH), Natural History Museum [Vienna] (NHM), Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Collège de France (CdF (institution))-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), Institut de minéralogie, de physique des matériaux et de cosmochimie (IMPMC), Muséum national d'Histoire naturelle (MNHN)-Institut de recherche pour le développement [IRD] : UR206-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Australian National University (ANU), Department of Earth and Planetary Science [Tokyo], Graduate School of Science [Tokyo], The University of Tokyo (UTokyo)-The University of Tokyo (UTokyo), Institut für Planetologie [Münster], Westfälische Wilhelms-Universität Münster (WWU), Centre de Recherches Pétrographiques et Géochimiques (CRPG), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Center for Meteorite Studies [Tempe], Arizona State University [Tempe] (ASU), National Institute of Polar Research [Tokyo] (NiPR), Astromaterials Research and Exploration Science (ARES), NASA Johnson Space Center (JSC), NASA-NASA, Field Museum of Natural History [Chicago, USA], University of Chicago, Department of Earth and Atmospheric Sciences [Edmonton], University of Alberta, Vernadsky Institute of Geochemistry and Analytical Chemistry (GEOKHI), Russian Academy of Sciences [Moscow] (RAS), Bavarian Research Institute of Experimental Geochemistry and Geophysics (Bayerisches Geoinstitut), Universität Bayreuth, Carnegie Institution for Science, Department of Earth Sciences [Casablanca], Faculté des Sciences Aïn Chock [Casablanca] (FSAC), Université Hassan II [Casablanca] (UH2MC)-Université Hassan II [Casablanca] (UH2MC), Laboratoire Géochimie, Traçage Isotopique, Minéral et élémentaire - G-Time (Bruxelles, Belgium), Colby College, Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Retired, Research School of Earth Sciences [Canberra] (RSES), Specola Vaticana/Vatican Observatory, Department of Mineral Sciences [Washington], Smithsonian Institution, Westfälische Wilhelms-Universität Münster = University of Münster (WWU), The Natural History Museum [London] (NHM), School of Geographical and Earth Sciences [Univ Glasgow], University of Glasgow, Planetary Science Institute [Tucson] (PSI), Institute of Space and Astronautical Science (ISAS), Japan Aerospace Exploration Agency [Sagamihara] (JAXA), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), The University of Tokyo (UTokyo), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Collège de France (CdF)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Laboratoire de minéralogie du Muséum National d'Histoire Naturelle (LMMNHN), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), The University of Tokyo, and Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)

Subjects
History, 010504 meteorology & atmospheric sciences, Best practice, [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], Library science, Généralités, 010502 geochemistry & geophysics, 01 natural sciences, Sciences de la terre et du cosmos, Geophysics, Meteorite, Space and Planetary Science, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences
Abstract

This document contains suggestions for best practices by authors who refer to meteorites in publications. It can also be taken as a guide for publishers in establishing guidelines for authors. The following best practices are recommended in addition to acknowledging the loaning institution or loaning individual (unless required otherwise). The main motivations are to: help ensure that research on meteorites is reproducible, prevent confusion in the literature, and enhance tracking of specimens and related data., SCOPUS: le.j, info:eu-repo/semantics/published

Published
2019

44. Concentration-dependent atomic mobilities in FCC CoCrFeMnNi high-entropy alloys

Author

Esin, Vladimir A., Gaertner, Daniel, Abrahams, Katrin, Kottke, Josua, Esin, Vladimir, Steinbach, Ingo, Wilde, Gerhard, Divinski, Sergiy, Centre des Matériaux (MAT), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), UMR 212 EME 'écosystèmes marins exploités' (EME), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Montpellier (UM), Interdisciplinary Centre for Advanced Materials Simulation (ICAMS), Ruhr-Universität Bochum [Bochum], Institute of Materials Physics, and Westfälische Wilhelms-Universität Münster (WWU)

Subjects
Materials science, Polymers and Plastics, Alloy, Continuum (design consultancy), Atomic mobility, FOS: Physical sciences, Thermodynamics, 02 engineering and technology, engineering.material, Kinetic energy, 01 natural sciences, TRACER, 0103 physical sciences, Diffusion (business), ComputingMilieux_MISCELLANEOUS, 010302 applied physics, Condensed Matter - Materials Science, High entropy alloys, Metals and Alloys, Materials Science (cond-mat.mtrl-sci), 021001 nanoscience & nanotechnology, Electronic, Optical and Magnetic Materials, Concentration dependent, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], Ceramics and Composites, engineering, 0210 nano-technology
Abstract

The diffusion kinetics in a CoCrFeMnNi high entropy alloy is investigated by a combined radiotracer--interdiffusion experiment applied to a pseudo-binary Co$_{15}$Cr$_{20}$Fe$_{20}$Mn$_{20}$Ni$_{25}$ / Co$_{25}$Cr$_{20}$Fe$_{20}$Mn$_{20}$Ni$_{15}$ couple. As a result, the composition-dependent tracer diffusion coefficients of Co, Cr, Fe and Mn are determined. The elements are characterized by significantly different diffusion rates, with Mn being the fastest element and Co being the slowest one. The elements having originally equiatomic concentration through the diffusion couple are found to reveal up-hill diffusion, especially Cr and Mn. The atomic mobility of Co seems to follow an S-shaped concentration dependence along the diffusion path. The experimentally measured kinetic data are checked against the existing CALPHAD-type databases. In order to ensure a consistent treatment of tracer and chemical diffusion a generalized symmetrized continuum approach for multi-component interdiffusion is proposed. Both, tracer and chemical diffusion concentration profiles are simulated and compared to the measurements. By using the measured tracer diffusion coefficients the chemical profiles can be described, almost perfectly, including up-hill diffusion., 15 pages, 7 figures

Published
2019

45. Effects of Mn2+, Ni2+, and Cu2+ on the Formation and Transformation of Hydrosulfate Green Rust: Reaction Processes and Underlying Mechanisms

Author

Bruno Lanson, Xionghan Feng, Xinran Liang, Lanxin Wang, Xiaoliang Liang, Jing Peng, Wenfeng Tan, Fan Liu, Mengqiang Zhu, Xiaoming Wang, Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), Laboratoire d'Automatique, Génie Informatique et Signal (LAGIS), Université de Lille, Sciences et Technologies-Centrale Lille-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences de la Terre (ISTerre), Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de recherche pour le développement [IRD] : UR219-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Research Institute of Xishuangbanna National Nature Reserve, Organisch-Chemisches Institut der Westfälischen Wilhelms-Universität Münster, and Westfälische Wilhelms-Universität Münster (WWU)

Subjects
inorganic chemicals, Atmospheric Science, Goethite, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, 010501 environmental sciences, engineering.material, 010502 geochemistry & geophysics, 01 natural sciences, law.invention, Metal, Geochemistry and Petrology, law, parasitic diseases, Green rust, Crystallization, Lepidocrocite, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, Chemistry, fungi, food and beverages, Transformation (genetics), Chemical engineering, Space and Planetary Science, visual_art, Soil water, visual_art.visual_art_medium, engineering
Abstract

Green rusts (GRs), which are important intermediate phases during Fe2+ oxidation, are commonly associated with various metal cations during their crystallization in soils and sediments, but the eff...

Published
2019

46. Grain boundary diffusion of 59Fe in high-purity copper

Author

Sergiy V. Divinski, Jens Ribbe, Vladimir A. Esin, Centre des Matériaux (MAT), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Institute of Materials Physics, and Westfälische Wilhelms-Universität Münster (WWU)

Subjects
Materials science, Polymers and Plastics, Iron, Enthalpy, Thermodynamics, chemistry.chemical_element, 02 engineering and technology, Kinetic energy, 01 natural sciences, Molecular dynamics, Grain boundary segregation, Grain boundary diffusion, Molecular dynamics simulation, 0103 physical sciences, Grain boundary diffusion coefficient, 010302 applied physics, Metals and Alloys, Penetration (firestop), 021001 nanoscience & nanotechnology, Copper, Electronic, Optical and Magnetic Materials, Grain boundary motion, chemistry, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], Ceramics and Composites, Grain boundary, Crystallite, 0210 nano-technology
Abstract

Grain boundary diffusion of iron in high purity polycrystalline copper is measured using the radiotracer technique and applying the 59Fe isotope. At lower temperatures, T 949 K, the measurements are performed under Harrison's C-type kinetic regime and the grain boundary diffusion coefficient of Fe in Cu, D gb , is determined, D gb = 5.6 ⋅ 10 − 6 × exp ( − 121 kJmol − 1 / R T ) m2/s. Unconventional penetration profiles are measured for Fe grain boundary diffusion in Cu at higher temperatures ( ≥ 949 K) under the intended B-type kinetic regime, in fact formal C-type profiles are systematically observed instead. Molecular dynamics simulation with the literature Finnis-Sinclair type interatomic potentials [Ackland et al., Phil. Mag. A, 1997] discovered an unexpected response of Cu grain boundaries on a partial Fe coverage at temperatures above 900 K. A model of Fe penetration in polycrystalline Cu in such conditions is proposed, which explains the untypical shape of the penetration profiles. The combination of the B- and C-type grain boundary diffusion measurements predict a strong segregation of Fe in Cu with a low segregation enthalpy.

Published
2019

47. Tracer diffusion in the Ni–CoCrFeMn system: Transition from a dilute solid solution to a high entropy alloy

Author

Loïc Perrière, Łukasz Rogal, Gerhard Wilde, Sergiy V. Divinski, Mathilde Laurent-Brocq, Adnan Fareed, Daniel Gaertner, Josua Kottke, Institut de Chimie et des Matériaux Paris-Est (ICMPE), Institut de Chimie du CNRS (INC)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Westfälische Wilhelms-Universität Münster (WWU), Institute of Materials Physics, Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), and Westfälische Wilhelms-Universität Münster = University of Münster (WWU)

Subjects
010302 applied physics, Materials science, Mechanical Engineering, Alloy, Metals and Alloys, Analytical chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, 02 engineering and technology, engineering.material, Blanket, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, Mechanics of Materials, TRACER, 0103 physical sciences, engineering, General Materials Science, 0210 nano-technology, ComputingMilieux_MISCELLANEOUS, Homologous temperature, Solid solution
Abstract

Tracer diffusion of Co, Cr, Fe and Ni is measured at 1373 K in Co20Cr20Fe20Mn20Ni20, Co10Cr10Fe10Mn10Ni60 and Co2Cr2Fe2Mn2Ni92 alloys. Diffusion retardation in the high-entropy Co20Cr20Fe20Mn20Ni20 alloy is most prominent in comparison to the Co2Cr2Fe2Mn2Ni92 solid solution, however the concept of ‘sluggish’ diffusion cannot be used as a blanket statement. The tracer diffusion coefficient drops either slightly (by a factor of three, Fe) or marginally (by a factor of 1.2, Ni) if compared at 1373 K. Alternatively, if compared on a homologous temperature scale, the diffusion retardation can be as large as a factor of 30 (Fe) or 10 (Ni).

Published
2019

48. USING VIRTUAL AND AUGMENTED REALITY FOR PLANETARY SURFACES INVESTIGATIONS -A CASE STUDY ON MARS AND THE MOON

Author

Stéphane Le Mouélic, Gwénaël CARAVACA, Nicolas Mangold, Jack Wright, Cristian Carli, Francesca Altieri, Francesca Zambon, Bogert, C. H., Riccardo Pozzobon, Massironi, M., Barbara de Toffoli, Angelo Pio Rossi, Laboratoire de Planétologie et Géodynamique [UMR 6112] (LPG), Université d'Angers (UA)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), School of Physical Sciences [Milton Keynes], Faculty of Science, Technology, Engineering and Mathematics [Milton Keynes], The Open University [Milton Keynes] (OU)-The Open University [Milton Keynes] (OU), Istituto di Astrofisica e Planetologia Spaziali - INAF (IAPS), Istituto Nazionale di Astrofisica (INAF), Institut für Planetologie [Münster], Westfälische Wilhelms-Universität Münster (WWU), Dipartimento di Geoscienze [Padova], Universita degli Studi di Padova, Deutsches Zentrum für Luft- und Raumfahrt [Berlin] (DLR), Jacobs University [Bremen], Lunar and Planetary Institute, European Project: 776276,PLANMAP, Westfälische Wilhelms-Universität Münster = University of Münster (WWU), and Università degli Studi di Padova = University of Padua (Unipd)

Subjects
Augmented Reality, [SDU.STU.PL]Sciences of the Universe [physics]/Earth Sciences/Planetology, planetary geology, [SDU]Sciences of the Universe [physics], [SDU.STU.ST]Sciences of the Universe [physics]/Earth Sciences/Stratigraphy, Virtual Reality, Mars, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, Moon, planetary surfaces
Abstract

International audience; Virtual Reality (VR) and Augmented Reality (AR) coupled with 3D terrain reconstructions are increasingly used for science, education and out-reach applications. These techniques are becom-ing more widespread thanks to the release since 2016 of reliable, versatile and cost-effective hardware solutions accessible to the general public. In the field of planetol-ogy, VR and AR theoretically allow the possibility to simulate field trips to remote places that are otherwise inaccessible to humans. Using high-resolution imaging, coupled with spectral or morphological data gathered by robotic explorers (orbiters, landers, rovers), we can cre-ate integrated virtual environments that accurately rep-resent the surface of planetary bodies and allow visual-ization and characterization of different datasets. These virtual environments provide the possibility to navigate on a global scale using orbital data, and move down to the surface when in situ data are available to explore and analyze local outcrops. This is particularly useful in the cases of the Moon and Mars, where both extensive or-bital and in situ data are available.

Published
2021

49. Search for inelastic scattering of WIMP dark matter in XENON1T

Author

A. Manfredini, L. Scotto Lavina, Hardy Simgen, A. D. Ferella, R. Budnik, Yuehuan Wei, L. Grandi, G. Koltman, C. Weinheimer, K. Martens, F. Arneodo, M. Messina, Lorne Levinson, F. Joerg, Kaixuan Ni, D. Cichon, N. Kato, C. Macolino, L. Hoetzsch, A. Elykov, T. Wolf, Elena Aprile, João Cardoso, M. Pierre, D. Ramírez García, F. Gao, Keita Mizukoshi, P. Shagin, J. A. M. Lopes, Y. Mosbacher, Y. Ma, Masaki Yamashita, P. Di Gangi, S. Moriyama, T. Zhu, F. D. Amaro, Guillaume Plante, Fabrizio Marignetti, M. Vargas, H. Landsman, M. P. Decowski, April S. Brown, Boris Bauermeister, Jochen Schreiner, D. Masson, T. Marrodán Undagoitia, L. Bellagamba, A. Rocchetti, S. Liang, Manfred Lindner, L. Althueser, K. Odgers, J. Howlett, Katsuki Hiraide, F. Lombardi, M. Alfonsi, S. Andaloro, J.M.F. dos Santos, F. Agostini, R. Di Stefano, V. Pizzella, Giacomo Bruno, J. Naganoma, N. Šarčević, J. Qin, Sebastian Lindemann, G. Sartorelli, J. Pienaar, C. Capelli, N. Rupp, Gian Carlo Trinchero, K. Morå, Michelle Galloway, H. Schulze Eißing, E. Angelino, S. Bruenner, A. Molinario, S. Mastroianni, Jean-Pierre Cussonneau, M. Iacovacci, A. Di Giovanni, Bart Pelssers, C. Tunnell, C. Wittweg, J. P. Zopounidis, D. Coderre, Manuel Gameiro da Silva, M. Scheibelhut, Jelle Aalbers, A. Depoian, M. Selvi, D. Schulte, Kathrin Valerius, A. Kopec, S. Reichard, Qing Lin, J. Qi, J. Palacio, J. Ye, B. Cimmino, M. Clark, Atsushi Takeda, Shingo Kazama, G. Volta, Uwe Oberlack, V. C. Antochi, Ethan Brown, Kentaro Miuchi, C. Therreau, J. Cuenca, Y. Zhang, Julien Masbou, Z. Xu, M. Murra, W. Fulgione, Laura Manenti, C. Hils, Sara Diglio, J. Mahlstedt, G. Zavattini, Laura Baudis, P. Gaemers, F. Toschi, M. L. Benabderrahmane, J. Long, J. R. Angevaare, E. Shockley, Jan Conrad, Masanori Kobayashi, R. Gaior, Yoshitaka Itow, M. Weiss, D. Thers, Marc Schumann, F. Semeria, R. F. Lang, A. P. Colijn, D. Wenz, R. Peres, A. Mancuso, Aprile, E., Aalbers, J., Agostini, F., Alfonsi, M., Althueser, L., Amaro, F. D., Andaloro, S., Angelino, E., Angevaare, J. R., Antochi, V. C., Arneodo, F., Baudis, L., Bauermeister, B., Bellagamba, L., Benabderrahmane, M. L., Brown, A., Brown, E., Bruenner, S., Bruno, G., Budnik, R., Capelli, C., Cardoso, J. M. R., Cichon, D., Cimmino, B., Clark, M., Coderre, D., Colijn, A. P., Conrad, J., Cuenca, J., Cussonneau, J. P., Decowski, M. P., Depoian, A., Di Gangi, P., Di Giovanni, A., Di Stefano, R., Diglio, S., Elykov, A., Ferella, A. D., Fulgione, W., Gaemers, P., Gaior, R., Galloway, M., Gao, F., Grandi, L., Hils, C., Hiraide, K., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Joerg, F., Kato, N., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Landsman, H., Lang, R. F., Levinson, L., Liang, S., Lin, Q., Lindemann, S., Lindner, M., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Manfredini, A., Marignetti, F., Marrodan Undagoitia, T., Martens, K., Masbou, J., Masson, D., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Mora, K., Moriyama, S., Mosbacher, Y., Murra, M., Naganoma, J., Ni, K., Oberlack, U., Odgers, K., Palacio, J., Pelssers, B., Peres, R., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., Ramirez Garcia, D., Reichard, S., Rocchetti, A., Rupp, N., Dos Santos, J. M. F., Sartorelli, G., Sarcevic, N., Scheibelhut, M., Schreiner, J., Schulte, D., Schulze Eissing, H., Schumann, M., Scotto Lavina, L., Selvi, M., Semeria, F., Shagin, P., Shockley, E., Silva, M., Simgen, H., Takeda, A., Therreau, C., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Valerius, K., Vargas, M., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, Z., Yamashita, M., Ye, J., Zavattini, G., Zhang, Y., Zhu, T., Zopounidis, J. P., XENON Collaboration, Columbia University [New York], Oskar Klein Centre [Stockholm], Stockholm University, University of Bologna, Johannes Gutenberg - Universität Mainz (JGU), Westfälische Wilhelms-Universität Münster (WWU), University of Coimbra [Portugal] (UC), Università degli studi di Torino (UNITO), University of Amsterdam [Amsterdam] (UvA), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), XENON, IoP (FNWI), and XENON (IHEF, IoP, FNWI)

Subjects
xenon: target, Photon, Physics::Instrumentation and Detectors, Parameter space, 01 natural sciences, WIMP: dark matter, High Energy Physics - Experiment, astro-ph.CO, High Energy Physics - Experiment (hep-ex), XENON, Recoil, WIMP, WIMP nucleus: cross section, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Dark Matter, parameter space, Nuclear Experiment, ComputingMilieux_MISCELLANEOUS, nucleus: recoil, Physics, Dark Matter, Inelastic scattering, XENON, Direct Dark Matter, photon, Astrophysics::Instrumentation and Methods for Astrophysics, Direct Dark Matter, Weakly interacting massive particles, signature, Astrophysics - Cosmology and Nongalactic Astrophysics, Particle physics, Inelastic scattering, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Dark matter, FOS: Physical sciences, WIMP: mass, Astrophysics::Cosmology and Extragalactic Astrophysics, NO, PE2_2, PE2_1, 0103 physical sciences, ddc:530, 010306 general physics, 010308 nuclear & particles physics, Scattering, WIMP nucleus: interaction, Dark, matter, WIMP: interaction, High Energy Physics::Experiment, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics and astroparticle physics, experimental results
Abstract

We report the results of a search for the inelastic scattering of weakly interacting massive particles (WIMPs) in the XENON1T dark matter experiment. Scattering off $^{129}$Xe is the most sensitive probe of inelastic WIMP interactions, with a signature of a 39.6 keV de-excitation photon detected simultaneously with the nuclear recoil. Using an exposure of 0.89 tonne-years, we find no evidence of inelastic WIMP scattering with a significance of more than 2$\sigma$. A profile-likelihood ratio analysis is used to set upper limits on the cross-section of WIMP-nucleus interactions. We exclude new parameter space for WIMPs heavier than 100 GeV/c${}^2$, with the strongest upper limit of $3.3 \times 10^{-39}$ cm${}^2$ for 130 GeV/c${}^2$ WIMPs at 90\% confidence level., Comment: 9 pages, 4 figures

Published
2021

50. Local field effects in ultrafast light-matter interaction measured by pump-probe spectroscopy of monolayer MoSe$_{\boldsymbol 2}$

Author

Daniel Wigger, Tilmann Kuhn, Piotr Kossacki, Marek Potemski, Karol Nogajewski, Aleksander Rodek, Tomasz Kazimierczuk, Thilo Hahn, Paweł Machnikowski, Jacek Kasprzak, Takashi Taniguchi, Kenji Watanabe, Karolina Połczyńska, University of Warsaw (UW), Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Nanophysique et Semiconducteurs (NPSC), Institut Néel (NEEL), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), National Institute for Materials Science (NIMS), Physikalisches Institut [Münster], Politechnika Wroclawska [Wrocław], Laboratoire national des champs magnétiques intenses - Grenoble (LNCMI-G ), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), University of Münster, Centre National de la Recherche Scientifique (CNRS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Université Grenoble Alpes (UGA), Westfälische Wilhelms-Universität Münster (WWU), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées

Subjects
QC1-999, Dephasing, FOS: Physical sciences, 02 engineering and technology, 01 natural sciences, Molecular physics, Spectral line, Mesoscale and Nanoscale Physics (cond-mat.mes-hall), 0103 physical sciences, Electrical and Electronic Engineering, 010306 general physics, Spectroscopy, Local field, Physics, Condensed Matter - Mesoscale and Nanoscale Physics, Scattering, local field effect, 021001 nanoscience & nanotechnology, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, nonlinear spectroscopy, Free induction decay, Excited state, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], transition metal dichalcogenide monolayer, 0210 nano-technology, Excitation, Biotechnology
Abstract

Using ultrafast resonant pump-probe spectroscopy in an unconventional experimental setup we investigate the spectral shape and dynamics of absorption features related to the A exciton in an hexagonal boron nitride (hBN)/MoSe2/hBN van der Waals heterostructure. While in a pure two-level system a pump-probe experiment measures the occupation or the polarization dynamics, depending on the time ordering of the pulse pair, in the transition metal dichalcogenide (TMD) system both quantities get thoroughly mixed by strong exciton–exciton interaction. We find that for short positive delays the spectral lines experience pronounced changes in their shape and energy and they relax to the original situation on a picosecond time scale. For negative delays, distinctive spectral oscillations appear indicating the first-time observation of perturbed free induction decay for a TMD system. The comparison between co-circular and cross-circular excitation schemes further allows us to investigate the rapid inter-valley scattering. By considering a three-level system as a minimal model including the local field effect, excitation-induced dephasing (EID), and scattering between the excited states we explain all phenomena observed in the experiment with excellent consistency. Our handy model can be even further reduced to two levels in the case of a co-circular excitation, for which we derive analytic expressions to describe the detected signals. This allows us to trace back the spectral shapes and shifts to the impact of local field effect and EID thus fully reproducing the complex behavior of the observed effects.

Published
2021

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