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2. The optimal healthy ranges of thyroid function defined by the risk of cardiovascular disease and mortality: systematic review and individual participant data meta-analysis

Author

Xu, Yanning, Derakhshan, Arash, Hysaj, Ola, Wildisen, Lea, Ittermann, Till, Pingitore, Alessandro, Abolhassani, Nazanin, Medici, Marco, Kiemeney, Lambertus A L M, Riksen, Niels P, Dullaart, Robin P F, Trompet, Stella, Dörr, Marcus, Brown, Suzanne J, Schmidt, Börge, Führer-Sakel, Dagmar, Vanderpump, Mark P J, Muendlein, Axel, Drexel, Heinz, Fink, Howard A, Ikram, M Kamran, Kavousi, Maryam, Rhee, Connie M, Bensenor, Isabela M, Azizi, Fereidoun, Hankey, Graeme J, Iacoviello, Massimo, Imaizumi, Misa, Ceresini, Graziano, Ferrucci, Luigi, Sgarbi, José A, Bauer, Douglas C, Wareham, Nick, Boelaert, Kristien, Bakker, Stephan J L, Jukema, J Wouter, Vaes, Bert, Iervasi, Giorgio, Yeap, Bu B, Westendorp, Rudi G J, Korevaar, Tim I M, Völzke, Henry, Razvi, Salman, Gussekloo, Jacobijn, Walsh, John P, Cappola, Anne R, Rodondi, Nicolas, Peeters, Robin P, and Chaker, Layal

Published
2023
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7. Incidence and Determinants of Spontaneous Normalization of Subclinical Hypothyroidism in Older Adults

Author

van der Spoel, Evie, primary, van Vliet, Nicolien A, additional, Poortvliet, Rosalinde K E, additional, Du Puy, Robert S, additional, den Elzen, Wendy P J, additional, Quinn, Terence J, additional, Stott, David J, additional, Sattar, Naveed, additional, Kearney, Patricia M, additional, Blum, Manuel R, additional, Alwan, Heba, additional, Rodondi, Nicolas, additional, Collet, Tinh-Hai, additional, Westendorp, Rudi G J, additional, Ballieux, Bart E, additional, Jukema, J Wouter, additional, Dekkers, Olaf M, additional, Gussekloo, Jacobijn, additional, Mooijaart, Simon P, additional, and van Heemst, Diana, additional

Published
2023
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10. Incidence and Determinants of Spontaneous Normalization of Subclinical Hypothyroidism in Older Adults.

Author

van der Spoel, Evie, van Vliet, Nicolien A., Poortvliet, Rosalinde K. E., Du Puy, Robert S., den Elzen, Wendy P. J., Quinn, Terence J., Stott, David J., Sattar, Naveed, Kearney, Patricia M., Blum, Manuel R., Alwan, Heba, Rodondi, Nicolas, Collet, Tinh-Hai, Westendorp, Rudi G. J., Ballieux, Bart E., Jukema, J. Wouter, Dekkers, Olaf M., Gussekloo, Jacobijn, Mooijaart, Simon P., and van Heemst, Diana

Subjects
HYPOTHYROIDISM, DISEASE incidence, HEALTH of older people
Abstract

Context: With age, the prevalence of subclinical hypothyroidism rises. However, incidence and determinants of spontaneous normalization remain largely unknown. Objective: To investigate incidence and determinants of spontaneous normalization of TSH levels in older adults with subclinical hypothyroidism. Design: Pooled data were used from the (1) pretrial population and (2) in-trial placebo group from 2 randomized, double-blind, placebo-controlled trials (Thyroid Hormone Replacement for Untreated Older Adults With Subclinical Hypothyroidism Trial and Institute for Evidence-Based Medicine in Old Age thyroid 80-plus thyroid trial). Setting: Community-dwelling 65+ adults with subclinical hypothyroidism from the Netherlands, Switzerland, Ireland, and the United Kingdom. Participants: The pretrial population (N = 2335) consisted of older adults with biochemical subclinical hypothyroidism, defined as ≥1 elevated TSH measurement (≥4.60 mIU/L) and a free T4 within the laboratory-specific reference range. Individuals with persistent subclinical hypothyroidism, defined as ≥2 elevated TSH measurements ≥3 months apart, were randomized to levothyroxine/placebo, of which the intrial placebo group (N = 361) was included. Main Outcome Measures: Incidence of spontaneous normalization of TSH levels and associations between participant characteristics and normalization. Results: In the pretrial phase, TSH levels normalized in 60.8% of participants in a median follow-up of 1 year. In the in-trial phase, levels normalized in 39.9% of participants after 1 year of follow-up. Younger age, female sex, lower initial TSH level, higher initial free T4 level, absence of thyroid peroxidase antibodies, and a follow-up measurement in summer were independent determinants for normalization. Conclusion: Because TSH levels spontaneously normalized in a large proportion of older adults with subclinical hypothyroidism (also after confirmation by repeat measurement), a third measurement may be recommended before considering treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Cardiovascular disease and the risk of incident falls and mortality among adults aged ≥ 65 years presenting to the emergency department: a cohort study from national registry data in Denmark.

Author

O'Halloran, Aisling M., Cremers, Jolien, Vrangbæk, Karsten, Roe, Lorna, Bourke, Robert, Mortensen, Laust H., Westendorp, Rudi G. J., and Kenny, Rose Anne

Subjects
HIP fractures, CARDIOVASCULAR diseases, COHORT analysis, HOSPITAL emergency services, AGE groups, CARDIOVASCULAR diseases risk factors, OLDER people, EMERGENCY nursing, DISABILITY retirement
Abstract

Background: Falls cause 58% of injury-related Emergency Department (ED) attendances. Previous research has highlighted the potential role of cardiovascular risk factors for falls. This study investigated the impact of cardiovascular disease (CVD) risk on three-year incident falls, with presentation to the ED, and mortality. Methods: A matched cohort study design was employed using national registry data from 82,292 adults (33% male) aged ≥ 65 years living in Denmark who attended the ED in 2013. We compared age and gender matched ED attendees presenting with a fall versus another reason. The cohort was followed for three-year incident falls, with presentation to the ED, and mortality. The impact of falls-related CVDs was also examined. Results: Three-year incident falls was twofold higher among age and gender matched ED attendees aged ≥ 65 years presenting with a fall versus another reason at baseline. A presentation of falls with hip fracture had the highest percentage of incident falls in the 65–74 age group (22%) and the highest percentage mortality in all age groups (27–62%). CVD was not a significant factor in presenting with a fall at the ED, nor did it contribute significantly to the prediction of three-year incident falls. CVD was strongly associated with mortality risk among the ED fall group (RR = 1.81, 95% CI: 1.67–1.97) and showed interactions with both age and fall history. Conclusion: In this large study of adults aged ≥ 65 years attending the ED utilising data from national administrative registers in Denmark, we confirm that older adults attending the ED with a fall, including those with hip fracture, were at greatest risk for future falls. While CVD did not predict incident falls, it increased the risk of mortality in the three-year follow up with advancing age. This may be informative for the provision of care pathways for older adults attending the ED due to a fall. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Reablement in need of theories of ageing: would theories of successful ageing do?

Author

Thuesen, Jette, Feiring, Marte, Doh, Daniel, and Westendorp, Rudi G. J.

Subjects
ACTIVE aging, MEDICAL care for older people, SOCIAL values, ATTITUDES toward aging, INDIVIDUALITY, ACTIVITIES of daily living, ELDER care, OPTIMISM, CULTURAL values
Abstract

The reablement approach is becoming a popular social and health-care model in many Western countries, providing support strategies for older people experiencing impairment. Reablement programmes have been criticised for a lack of theories, explicating the understanding of the problem that it is intended to address, i.e. ageing and impairment in old age. We need to discuss the inherent theories in intervention programmes to question taken-for-granted assumptions about not only what works, but also how these assumptions affect the sociocultural models of ageing. Theories on successful ageing have been suggested as underpinning reablement. This article aims to present and discuss theories of successful ageing compared to key principles, components and outcomes in reablement. A medical and epidemiological, a psychological and a sociocultural theoretical approach to successful ageing are included. Contemporary reablement programmes mirror medical and psychological theories of successful ageing, including models of ageing that are associated with continuity, optimisation, selection, individuality and goal orientation. Most reablement programmes do not address sociocultural perspectives on ageing. As older people experience impairment in a pertinent liminality within and between the sociocultural values of the third and fourth age, it is important for reablement programmes and practice to consider the theoretical assumptions and underpinning theories of ageing and how to help older people balance between optimising capacity and accepting losses in their everyday life. [ABSTRACT FROM AUTHOR]

Published
2023
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17. HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

Author

Swerdlow, Daniel I, Preiss, David, Kuchenbaecker, Karoline B, Holmes, Michael V, Engmann, Jorgen E L, Shah, Tina, Sofat, Reecha, Stender, Stefan, Johnson, Paul C D, Scott, Robert A, Leusink, Maarten, Verweij, Niek, Sharp, Stephen J, Guo, Yiran, Giambartolomei, Claudia, Chung, Christina, Peasey, Anne, Amuzu, Antoinette, Li, KaWah, Palmen, Jutta, Howard, Philip, Cooper, Jackie A, Drenos, Fotios, Li, Yun R, Lowe, Gordon, Gallacher, John, Stewart, Marlene C W, Tzoulaki, Ioanna, Buxbaum, Sarah G, van der A, Daphne L, Forouhi, Nita G, Onland-Moret, N Charlotte, van der Schouw, Yvonne T, Schnabel, Renate B, Hubacek, Jaroslav A, Kubinova, Ruzena, Baceviciene, Migle, Tamosiunas, Abdonas, Pajak, Andrzej, Topor-Madry, Romanvan, Stepaniak, Urszula, Malyutina, Sofia, Baldassarre, Damiano, Sennblad, Bengt, Tremoli, Elena, de Faire, Ulf, Veglia, Fabrizio, Ford, Ian, Jukema, J Wouter, Westendorp, Rudi G J, de Borst, Gert Jan, de Jong, Pim A, Algra, Ale, Spiering, Wilko, der Zee, Anke H Maitland-van, Klungel, Olaf H, de Boer, Anthonius, Doevendans, Pieter A, Eaton, Charles B, Robinson, Jennifer G, Duggan, David, Kjekshus, John, Downs, John R, Gotto, Antonio M, Keech, Anthony C, Marchioli, Roberto, Tognoni, Gianni, Sever, Peter S, Poulter, Neil R, Waters, David D, Pedersen, Terje R, Amarenco, Pierre, Nakamura, Haruo, McMurray, John J V, Lewsey, James D, Chasman, Daniel I, Ridker, Paul M, Maggioni, Aldo P, Tavazzi, Luigi, Ray, Kausik K, Seshasai, Sreenivasa Rao Kondapally, Manson, JoAnn E, Price, Jackie F, Whincup, Peter H, Morris, Richard W, Lawlor, Debbie A, Smith, George Davey, Ben-Shlomo, Yoav, Schreiner, Pamela J, Fornage, Myriam, Siscovick, David S, Cushman, Mary, Kumari, Meena, Wareham, Nick J, Verschuren, W M Monique, Redline, Susan, Patel, Sanjay R, Whittaker, John C, Hamsten, Anders, Delaney, Joseph A, Dale, Caroline, Gaunt, Tom R, Wong, Andrew, Kuh, Diana, Hardy, Rebecca, Kathiresan, Sekar, Castillo, Berta A, van der Harst, Pim, Brunner, Eric J, Tybjaerg-Hansen, Anne, Marmot, Michael G, Krauss, Ronald M, Tsai, Michael, Coresh, Josef, Hoogeveen, Ronald C, Psaty, Bruce M, Lange, Leslie A, Hakonarson, Hakon, Dudbridge, Frank, Humphries, Steve E, Talmud, Philippa J, Kivimäki, Mika, Timpson, Nicholas J, Langenberg, Claudia, Asselbergs, Folkert W, Voevoda, Mikhail, Bobak, Martin, Pikhart, Hynek, Wilson, James G, Reiner, Alex P, Keating, Brendan J, Hingorani, Aroon D, and Sattar, Naveed

Published
2015
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18. Subclinical thyroid dysfunction and incident diabetes: a systematic review and an individual participant data analysis of prospective cohort studies

Author

Alwan, Heba, primary, Villoz, Fanny, additional, Feller, Martin, additional, Dullaart, Robin P F, additional, Bakker, Stephan J L, additional, Peeters, Robin P, additional, Kavousi, Maryam, additional, Bauer, Douglas C, additional, Cappola, Anne R, additional, Yeap, Bu B, additional, Walsh, John P, additional, Brown, Suzanne J, additional, Ceresini, Graziano, additional, Ferrucci, Luigi, additional, Gussekloo, Jacobijn, additional, Trompet, Stella, additional, Iacoviello, Massimo, additional, Moon, Jae Hoon, additional, Razvi, Salman, additional, Bensenor, Isabela M, additional, Azizi, Fereidoun, additional, Amouzegar, Atieh, additional, Valdés, Sergio, additional, Colomo, Natalia, additional, Wareham, Nick J, additional, Jukema, J Wouter, additional, Westendorp, Rudi G J, additional, Kim, Ki Woong, additional, Rodondi, Nicolas, additional, and Del Giovane, Cinzia, additional

Published
2022
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22. Thyroid Function Within the Normal Range, Subclinical Hypothyroidism, and the Risk of Atrial Fibrillation

Author

Baumgartner, Christine, da Costa, Bruno R., Collet, Tinh-Hai, Feller, Martin, Floriani, Carmen, Bauer, Douglas C., Cappola, Anne R., Heckbert, Susan R., Ceresini, Graziano, Gussekloo, Jacobijn, den Elzen, Wendy P.J., Peeters, Robin P., Luben, Robert, Völzke, Henry, Dörr, Marcus, Walsh, John P., Bremner, Alexandra, Iacoviello, Massimo, Macfarlane, Peter, Heeringa, Jan, Stott, David J., Westendorp, Rudi G. J., Khaw, Kay-Tee, Magnani, Jared W., Aujesky, Drahomir, and Rodondi, Nicolas

Published
2017
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24. Additional file 1 of Do changes in frailty, physical functioning, and cognitive functioning predict mortality in old age? Results from the Longitudinal Aging Study Amsterdam

Author

Kusumastuti, Sasmita, Hoogendijk, Emiel O., Gerds, Thomas A., Lund, Rikke, Mortensen, Erik L., Huisman, Martijn, and Westendorp, Rudi G. J.

Abstract

Additional file 1: Supplementary Figure S1. Selection of Study Sample. Supplementary Table S2. Items Included inthe Frailty Index. Supplementary Figure S3. Study Design Scheme. Supplementary Figure S4. Distribution of Current Status and Three-year Change in Health Indicators Stratified for Sex. Supplementary Table S5. Added Value of HealthIndicators to Mortality Prediction Stratified for Sex. Supplementary Table S6. Added Value of Health Indicators to Mortality Prediction Based on Age and Sex Stratified for Number of Chronic Diseases.

Published
2022
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25. No effect of levothyroxine on hemoglobin in older adults with subclinical hypothyroidism: pooled results from two RCTs

Author

Du Puy, Robert S, Poortvliet, Rosalinde K E, Mooijaart, Simon P, Stott, David J, Quinn, Terry, Sattar, Naveed, Westendorp, Rudi G J, Kearney, Patricia M, McCarthy, Vera J C, Byrne, Stephen, Rodondi, Nicolas, Baretella, Oliver, Collet, Tinh-Hai, van Heemst, Diana, Dekkers, Olaf M, Jukema, J Wouter, Smit, Johannes W A, Gussekloo, Jacobijn, and den Elzen, Wendy P J

Subjects
360 Social problems & social services, 610 Medicine & health
Abstract

CONTEXT Subclinical thyroid dysfunction and anemia are common disorders, and both have increasing prevalence numbers with advancing age. OBJECTIVE The aim of this study was to assess whether levothyroxine treatment leads to a rise in hemoglobin levels in older persons with subclinical hypothyroidism. DESIGN A pre-planned combined analysis of two randomized controlled trials. PARTICIPANTS Community-dwelling persons aged 65 years and older with subclinical hypothyroidism. INTERVENTION Participants were randomly assigned to levothyroxine or placebo treatment. The dose of levothyroxine was periodically titrated aiming at thyroid stimulating hormone (TSH) level within the reference range and mock titrations in the placebo group. MAIN OUTCOME MEASURE The main outcome measure was the change in hemoglobin level after 12 months. RESULTS Analyses included 669 participants (placebo n=337, levothyroxine n=332) with a median age of 75 years (range 65 to 97) and mean baseline hemoglobin of 13.8��1.3��g/dL. Although levothyroxine treatment resulted in a reduction in TSH from baseline after 12 months of follow-up compared to placebo, the change in hemoglobin level was not different between the levothyroxine and the placebo groups (-0.03��g/dL [95%CI -0.16 to 0.11]). Similar results were found in stratified analyses including sex, age or TSH levels. No difference in change of hemoglobin levels after 12 months was identified in 69 participants with anemia at baseline (-0.33��g/dL [95% CI -0.87 to 0.21]). CONCLUSIONS In persons aged 65 years and older with subclinical hypothyroidism, treatment with levothyroxine does not lead to a rise in hemoglobin levels, regardless of the presence of anemia.

Published
2022
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26. No effect of levothyroxine on hemoglobin in older adults with subclinical hypothyroidism: pooled results from two Randomized Controlled Trials

Author

Du Puy, Robert S, Poortvliet, Rosalinde K E, Mooijaart, Simon P, Stott, David J, Quinn, Terry, Sattar, Naveed, Westendorp, Rudi G J, Kearney, Patricia M, McCarthy, Vera J C, Byrne, Stephen, Rodondi, Nicolas, Baretella, Oliver, Collet, Tinh-Hai, van Heemst, Diana, Dekkers, Olaf M, Jukema, J Wouter, Smit, Johannes W A, Gussekloo, Jacobijn, and den Elzen, Wendy P J

Subjects
ddc:616, Thyroid, Subclinical hypothyroidism, Older adults, Anemia, RCT
Abstract

Context: Subclinical thyroid dysfunction and anemia are common disorders, and both have increasing prevalence with advancing age.Objective: The aim of this study was to assess whether levothyroxine treatment leads to a rise in hemoglobin levels in older persons with subclinical hypothyroidism.Methods: This preplanned combined analysis of 2 randomized controlled trials included community-dwelling persons aged 65 years and older with subclinical hypothyroidism who were randomly assigned to levothyroxine or placebo treatment. The levothyroxine dose was periodically titrated aiming at thyroid stimulating hormone (TSH) level within the reference range, with mock titrations in the placebo group. The main outcome measure was the change in hemoglobin level after 12 months.Results: Analyses included 669 participants (placebo n = 337, levothyroxine n = 332) with a median age of 75 years (range, 65-97) and mean baseline hemoglobin of 13.8 ± 1.3 g/dL. Although levothyroxine treatment resulted in a reduction in TSH from baseline after 12 months of follow-up compared with placebo, the change in hemoglobin level was not different between the levothyroxine and the placebo groups (-0.03 g/dL [95% CI, -0.16 to 0.11]). Similar results were found in stratified analyses including sex, age, or TSH levels. No difference in change of hemoglobin levels after 12 months was identified in 69 participants with anemia at baseline (-0.33 g/dL [95% CI, -0.87 to 0.21]).Conclusion: In persons aged 65 years and older with subclinical hypothyroidism, treatment with levothyroxine does not lead to a rise in hemoglobin levels, regardless of the presence of anemia.

Published
2022

31. No Effect of Levothyroxine on Hemoglobin in Older Adults With Subclinical Hypothyroidism: Pooled Results From 2 Randomized Controlled Trials

Author

Du Puy, Robert S, primary, Poortvliet, Rosalinde K E, additional, Mooijaart, Simon P, additional, Stott, David J, additional, Quinn, Terry, additional, Sattar, Naveed, additional, Westendorp, Rudi G J, additional, Kearney, Patricia M, additional, McCarthy, Vera J C, additional, Byrne, Stephen, additional, Rodondi, Nicolas, additional, Baretella, Oliver, additional, Collet, Tinh-Hai, additional, van Heemst, Diana, additional, Dekkers, Olaf M, additional, Jukema, J Wouter, additional, Smit, Johannes W A, additional, Gussekloo, Jacobijn, additional, and den Elzen, Wendy P J, additional

Published
2022
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33. Incorporating Baseline Outcome Data in Individual Participant Data Meta-Analysis of Non-randomized Studies

Author

Syrogiannouli, Lamprini, primary, Wildisen, Lea, additional, Meuwese, Christiaan, additional, Bauer, Douglas C., additional, Cappola, Anne R., additional, Gussekloo, Jacobijn, additional, den Elzen, Wendy P. J., additional, Trompet, Stella, additional, Westendorp, Rudi G. J., additional, Jukema, J. Wouter, additional, Ferrucci, Luigi, additional, Ceresini, Graziano, additional, Åsvold, Bjørn O., additional, Chaker, Layal, additional, Peeters, Robin P., additional, Imaizumi, Misa, additional, Ohishi, Waka, additional, Vaes, Bert, additional, Völzke, Henry, additional, Sgarbi, Josè A., additional, Walsh, John P., additional, Dullaart, Robin P. F., additional, Bakker, Stephan J. L., additional, Iacoviello, Massimo, additional, Rodondi, Nicolas, additional, and Del Giovane, Cinzia, additional

Published
2022
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38. Cholesterol and risk of stroke

Author

de Craen, Anton J M, Blauw, Gerard J, Westendorp, Rudi G J, Ovbiagele, Bruce, and Kendrick, Malcolm E

Published
2006

39. Long‐Term Exposure to Air Pollution, Road Traffic Noise, and Heart Failure Incidence: The Danish Nurse Cohort

Author

Lim, Youn‐Hee, primary, Jørgensen, Jeanette T., additional, So, Rina, additional, Cole‐Hunter, Tom, additional, Mehta, Amar J., additional, Amini, Heresh, additional, Bräuner, Elvira V., additional, Westendorp, Rudi G. J., additional, Liu, Shuo, additional, Mortensen, Laust H., additional, Hoffmann, Barbara, additional, Loft, Steffen, additional, Ketzel, Matthias, additional, Hertel, Ole, additional, Brandt, Jørgen, additional, Jensen, Steen Solvang, additional, Backalarz, Claus, additional, Simonsen, Mette K., additional, Tasic, Nebojsa, additional, Maric, Matija, additional, and Andersen, Zorana J., additional

Published
2021
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46. Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials

Author

Sattar, Naveed, Preiss, David, Murray, Heather M, Welsh, Paul, Buckley, Brendan M, de Craen, Anton JM, Seshasai, Sreenivasa Rao Kondapally, McMurray, John J, Freeman, Dilys J, Jukema, J Wouter, Macfarlane, Peter W, Packard, Chris J, Stott, David J, Westendorp, Rudi G, Shepherd, James, Davis, Barry R, Pressel, Sara L, Marchioli, Roberto, Marfisi, Rosa Maria, Maggioni, Aldo P, Tavazzi, Luigi, Tognoni, Gianni, Kjekshus, John, Pedersen, Terje R, Cook, Thomas J, Gotto, Antonio M, Clearfield, Michael B, Downs, John R, Nakamura, Haruo, Ohashi, Yasuo, Mizuno, Kyoichi, Ray, Kausik K, and Ford, Ian

Published
2010
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50. Subclinical Hypothyroidism and the Risk of Stroke Events and Fatal Stroke: An Individual Participant Data Analysis

Author

Chaker, Layal, Baumgartner, Christine, den Elzen, Wendy P. J., Ikram, M. Arfan, Blum, Manuel R., Collet, Tinh-Hai, Bakker, Stephan J. L., Dehghan, Abbas, Drechsler, Christiane, Luben, Robert N., Hofman, Albert, Portegies, Marileen L. P., Medici, Marco, Iervasi, Giorgio, Stott, David J., Ford, Ian, Bremner, Alexandra, Wanner, Christoph, Ferrucci, Luigi, Newman, Anne B., Dullaart, Robin P., Sgarbi, José A., Ceresini, Graziano, Maciel, Rui M. B., Westendorp, Rudi G., Jukema, J. Wouter, Imaizumi, Misa, Franklyn, Jayne A., Bauer, Douglas C., Walsh, John P., Razvi, Salman, Khaw, Kay-Tee, Cappola, Anne R., Völzke, Henry, Franco, Oscar H., Gussekloo, Jacobijn, Rodondi, Nicolas, and Peeters, Robin P.

Published
2015

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