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4,932 results on '"Wesley, D"'

2. Implantable silicon neural probes with nanophotonic phased arrays for single-lobe beam steering

Author

Chen, Fu-Der, Sharma, Ankita, Xue, Tianyuan, Jung, Youngho, Govdeli, Alperen, Mak, Jason C. C., Chameh, Homeira Moradi, Movahed, Mandana, Brunk, Michael G. K., Luo, Xianshu, Chua, Hongyao, Lo, Patrick Guo-Qiang, Valiante, Taufik A, Sacher, Wesley D., and Poon, Joyce K. S.

Subjects
Physics - Optics, Physics - Biological Physics
Abstract

In brain activity mapping experiments using optogenetics, patterned illumination is crucial for deterministic and localized stimulation of neurons. However, due to optical scattering in brain tissue, light-emitting implantable devices are needed to bring precise patterned illumination to deep brain regions. A promising solution is silicon neural probes with integrated nanophotonic circuits that form tailored beam emission patterns without lenses. Here, we demonstrate neural probes with grating-based light emitters that generate a single steerable light beam across $> 60\%$ of the steering range with $\ge 4$ dB of background suppression for optogenetic photostimulation. The light emitters, optimized for blue or amber light, combine end-fire optical phased arrays with slab gratings to suppress higher-order sidelobes., Comment: 32 pages, 7 figures

Published
2024

3. Implantable Photonic Neural Probes with Out-of-Plane Focusing Grating Emitters

Author

Xue, Tianyuan, Stalmashonak, Andrei, Chen, Fu-Der, Ding, Peisheng, Luo, Xianshu, Chua, Hongyao, Lo, Guo-Qiang, Sacher, Wesley D., and Poon, Joyce K. S.

Subjects
Physics - Optics
Abstract

We have designed, fabricated, and characterized implantable silicon neural probes with nanophotonic grating emitters that focus the emitted light at a specified distance above the surface of the probe for spatially precise optogenetic targeting of neurons. Using the holographic principle, we designed gratings for wavelengths of 488 and 594 nm, targeting the excitation spectra of the optogenetic actuators Channelrhodopsin-2 and Chrimson, respectively. The measured optical emission pattern of these emitters in non-scattering medium and tissue matched well with simulations. To our knowledge, this is the first report of focused spots with the size scale of a neuron soma in brain tissue formed from implantable neural probes., Comment: 11 pages, 6 figures

Published
2024

4. Room-temperature waveguide-coupled silicon single-photon avalanche diodes

Author

Govdeli, Alperen, Straguzzi, John N., Yong, Zheng, Lin, Yiding, Luo, Xianshu, Chua, Hongyao, Lo, Guo-Qiang, Sacher, Wesley D., and Poon, Joyce K. S.

Subjects
Physics - Optics, Physics - Applied Physics
Abstract

Single photon detection is important for a wide range of low-light applications, including quantum information processing, spectroscopy, and light detection and ranging (LiDAR). A key challenge in these applications has been to integrate single-photon detection capability into photonic circuits for the realization of complex photonic microsystems. Short-wavelength ($\lambda$ < 1.1 $\mu$m) integrated photonics platforms that use silicon (Si) as photodetectors offer the opportunity to achieve single-photon avalanche diodes (SPADs) that operate at or near room temperature. Here, we report the first waveguide-coupled Si SPAD. The device is monolithically integrated in a Si photonic platform and operates in the visible spectrum. The device exhibited a single photon detection efficiency of > 6% for wavelengths of 488 nm and 532 nm with an excess voltage less than 20% of the breakdown voltage. The dark count rate was below 100 kHz at room temperature, with the possibility of improving by approximately 35% by reducing the temperature to -5$^{\circ}$C.

Published
2023

8. Dalbavancin Sequential Therapy for Gram-Positive Bloodstream Infection: A Multicenter Observational Study

Author

Rebold, Nicholas, Alosaimy, Sara, Pearson, Jeffrey C., Dionne, Brandon, Taqi, Ahmad, Lagnf, Abdalhamid, Lucas, Kristen, Biagi, Mark, Lombardo, Nicholas, Eudy, Joshua, Anderson, Daniel T., Mahoney, Monica V., Kufel, Wesley D., D’Antonio, Joseph A., Jones, Bruce M., Frens, Jeremy J., Baumeister, Tyler, Geriak, Matthew, Sakoulas, George, Farmakiotis, Dimitrios, Delaportas, Dino, Larew, Jeremy, Veve, Michael P., and Rybak, Michael J.

Published
2024
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9. Implantable Photonic Neural Probes with 3D-Printed Microfluidics and Applications to Uncaging

Author

Mu, Xin, Chen, Fu-Der, Dang, Ka My, Brunk, Michael G. K., Li, Jianfeng, Wahn, Hannes, Stalmashonak, Andrei, Ding, Peisheng, Luo, Xianshu, Chua, Hongyao, Lo, Guo-Qiang, Poon, Joyce K. S., and Sacher, Wesley D.

Subjects
Physics - Optics, Physics - Applied Physics
Abstract

Advances in chip-scale photonic-electronic integration are enabling a new generation of foundry-manufacturable implantable silicon neural probes incorporating nanophotonic waveguides and microelectrodes for optogenetic stimulation and electrophysiological recording in neuroscience research. Further extending neural probe functionalities with integrated microfluidics is a direct approach to achieve neurochemical injection and sampling capabilities. In this work, we use two-photon polymerization 3D printing to integrate microfluidic channels onto photonic neural probes, which include silicon nitride nanophotonic waveguides and grating emitters. The customizability of 3D printing enables a unique geometry of microfluidics that conforms to the shape of each neural probe, enabling integration of microfluidics with a variety of existing neural probes while avoiding the complexities of monolithic microfluidics integration. We demonstrate the photonic and fluidic functionalities of the neural probes via fluorescein injection in agarose gel and photoloysis of caged fluorescein in solution and in flxed brain tissue.

Published
2023
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10. Implantable photonic neural probes with out-of-plane focusing grating emitters

Author

Tianyuan Xue, Andrei Stalmashonak, Fu-Der Chen, Peisheng Ding, Xianshu Luo, Hongyao Chua, Guo-Qiang Lo, Wesley D. Sacher, and Joyce K. S. Poon

Subjects
Medicine, Science
Abstract

Abstract We have designed, fabricated, and characterized implantable silicon neural probes with nanophotonic grating emitters that focus the emitted light at a specified distance above the surface of the probe for spatially precise optogenetic targeting of neurons. Using the holographic principle, we designed gratings for wavelengths of 488 and 594 nm, targeting the excitation spectra of the optogenetic actuators Channelrhodopsin-2 and Chrimson, respectively. The measured optical emission pattern of these emitters in non-scattering medium and tissue matched well with simulations. To our knowledge, this is the first report of focused spots with the size scale of a neuron soma in brain tissue formed from implantable neural probes.

Published
2024
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11. Characterization of Fast Ion Transport via Position-Dependent Optical Deshelving

Author

Clark, Craig R., Herold, Creston D., Merrill, J. True, Tinkey, Holly N., Rellergert, Wade, Clark, Robert, Brown, Roger, Robertson, Wesley D., Volin, Curtis, Maller, Kara, Shappert, Chris, McMahon, Brian J., Sawyer, Brian C., and Brown, Kenton R.

Subjects
Quantum Physics, Physics - Atomic Physics
Abstract

Ion transport is an essential operation in some models of quantum information processing, where fast ion shuttling with minimal motional excitation is necessary for efficient, high-fidelity quantum logic. While fast and cold ion shuttling has been demonstrated, the dynamics and specific trajectory of an ion during diabatic transport have not been studied in detail. Here we describe a position-dependent optical deshelving technique useful for sampling an ion's position throughout its trajectory, and we demonstrate the technique on fast linear transport of a $^{40}\text{Ca}^+$ ion in a surface-electrode ion trap. At high speed, the trap's electrode filters strongly distort the transport potential waveform. With this technique, we observe deviations from the intended constant-velocity (100 m/s) transport: we measure an average speed of 83(2) m/s and a peak speed of 251(6) m/s over a distance of 120 $\mu$m

Published
2023
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12. Revision of the strongly flattened Megaprosternum Azevedo (Hymenoptera, Bethylidae)

Author

Wesley D. Colombo and Celso O. Azevedo

Subjects
Australia, Madagascar, Oceanian, Chrysidoidea, Scleroderminae, Zoology, QL1-991, Botany, QK1-989
Abstract

The flat wasp genus Megaprosternum (Scleroderminae) is studied and revised. Fifteen species are recognized, including five previously described ones: M. cleonarovorum, M. longiceps, M. neolongiceps, M. norfolcensis, and M. pentagonal. Additionally, 10 new species are described and illustrated: M. aka sp. nov. and M. bayaka sp. nov. (both from the Central African Rep.), M. chamorro sp. nov., M. hmong sp. nov., M. kariri sp. nov., M. kayin sp. nov., M. navatu sp. nov., M. nuaulu sp. nov., M. samburu sp. nov., and M. wakawaka sp. nov. An emended diagnosis and a detailed discussion regarding the morphological diagnostic characters of this genus and its species, along with comments about the distribution pattern of Megaprosternum, are also presented. Additionally, a taxonomic key for males and females of all species is provided.

Published
2024
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15. Monolithically Integrated Visible-Light MEMS Switch

Author

Govdeli, Alperen, Chen, Hong, Azadeh, Saeed S., Straguzzi, John N., Chua, Hongyao, Lo, Guo-Qiang, Poon, Joyce K. S., Sacher, Wesley D., Witzens, Jeremy, editor, Poon, Joyce, editor, Zimmermann, Lars, editor, and Freude, Wolfgang, editor

Published
2024
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21. 3D printed titanium carbide MXene-coated polycaprolactone scaffolds for guided neuronal growth and photothermal stimulation

Author

Jianfeng Li, Payam Hashemi, Tianyi Liu, Ka My Dang, Michael G. K. Brunk, Xin Mu, Ali Shaygan Nia, Wesley D. Sacher, Xinliang Feng, and Joyce K. S. Poon

Subjects
Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract

Abstract The exploration of neural circuitry is paramount for comprehending the computational mechanisms and physiology of the brain. Despite significant advances in materials and fabrication techniques, controlling neuronal connectivity and response in 3D remains a formidable challenge. Here, we introduce a method for engineering the growth of 3D neural circuits with the capability for optical stimulation. We fabricate bioactive interfaces by melt electrospinning writing (MEW) 3D polycaprolactone (PCL) scaffolds followed by coating with titanium carbide (Ti3C2Tx MXene). Beyond enhancing hydrophilicity, cell adhesion, and electrical conductivity, the Ti3C2Tx MXene coating enables optocapacitance-based neuronal stimulation, induced by localized temperature increases upon illumination. This approach offers a pathway for additive manufacturing of neural tissues endowed with optical control, facilitating functional tissue engineering and neural circuit computation.

Published
2024
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22. Optimization of a programmable λ/2-pitch optical phased array

Author

Sharma Ankita, Straguzzi John N., Xue Tianyuan, Govdeli Alperen, Chen Fu Der, Stalmashonak Andrei, Sacher Wesley D., and Poon Joyce K. S.

Subjects
silicon photonics, optical phased array, programmable photonics, optimization, crosstalk, Physics, QC1-999
Abstract

A challenge in optical phased arrays (OPAs) is to achieve single-lobe emission using densely spaced emitters without incurring inter-waveguide optical crosstalk. Here, we propose to heuristically optimize the amplitude and phase of each grating antenna in an OPA to correct for optical non-idealities, including fabrication variations and inter-waveguide crosstalk. This method was applied to a silicon photonic integrated circuit with 1 mm-long gratings at 775 nm spacing for operation in a wavelength range of 1450–1650 nm. We achieved a wide two-dimensional beam-steering range of 110° × 28°, evaluated over a 127° × 47° field-of-view (FOV). Within this FOV, we measured an average sidelobe suppression of 8.2 dB and focused on average, 34.5 % of the emitted power into the main lobe. We achieved a peak sidelobe suppression of 14.5 dB and 50 % of the power concentrated in the main lobe. The approach is suitable for applications that require alias-free out-of-plane emission.

Published
2024
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23. Dalbavancin Sequential Therapy for Gram-Positive Bloodstream Infection: A Multicenter Observational Study

Author

Nicholas Rebold, Sara Alosaimy, Jeffrey C. Pearson, Brandon Dionne, Ahmad Taqi, Abdalhamid Lagnf, Kristen Lucas, Mark Biagi, Nicholas Lombardo, Joshua Eudy, Daniel T. Anderson, Monica V. Mahoney, Wesley D. Kufel, Joseph A. D’Antonio, Bruce M. Jones, Jeremy J. Frens, Tyler Baumeister, Matthew Geriak, George Sakoulas, Dimitrios Farmakiotis, Dino Delaportas, Jeremy Larew, Michael P. Veve, and Michael J. Rybak

Subjects
Bacteremia, Bloodstream infection, Dalbavancin, Injection drug use, Glycopeptides, Staphylococcus, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Introduction Long-acting lipoglycopeptides such as dalbavancin may have utility in patients with Gram-positive bloodstream infections (BSI), particularly in those with barriers to discharge or who require prolonged parenteral antibiotic courses. A retrospective cohort study was performed to provide further multicenter real-world evidence on dalbavancin use as a sequential therapy for Gram-positive BSI. Methods One hundred fifteen patients received dalbavancin with Gram-positive BSI, defined as any positive blood culture or diagnosed with infective endocarditis, from 13 centers geographically spread across the United States between July 2015 and July 2021. Results Patients had a mean (SD) age of 48.5 (17.5) years, the majority were male (54%), with many who injected drugs (40%). The most common infection sources (non-exclusive) were primary BSI (89%), skin and soft tissue infection (SSTI) (25%), infective endocarditis (19%), and bone and joint infection (17%). Staphylococcus aureus accounted for 72% of index cultures, coagulase-negative Staphylococcus accounted for 18%, and Streptococcus species in 16%. Dalbavancin started a median (Q1–Q3) of 10 (6–19) days after index culture collection. The most common regimen administered was dalbavancin 1500 mg as one dose for 50% of cases. The primary outcome of composite clinical failure occurred at 12.2%, with 90-day mortality at 7.0% and 90-day BSI recurrence at 3.5%. Conclusions Dalbavancin may serve as a useful tool in facilitating hospital discharge in patients with Gram-positive BSI. Randomized controlled trials are anticipated to validate dalbavancin as a surrogate to current treatment standards.

Published
2024
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24. Microcantilever-integrated photonic circuits for broadband laser beam scanning

Author

Azadeh, Saeed Sharif, Mak, Jason C. C., Chen, Hong, Luo, Xianshu, Chen, Fu-Der, Chua, Hongyao, Weiss, Frank, Alexiev, Christopher, Stalmashonak, Andrei, Jung, Youngho, Straguzzi, John N., Lo, Guo-Qiang, Sacher, Wesley D., and Poon, Joyce K. S.

Subjects
Physics - Optics, Physics - Applied Physics
Abstract

Laser beam scanning is central to many applications, including displays, microscopy, three-dimensional mapping, and quantum information. Reducing the scanners to microchip form factors has spurred the development of very-large-scale photonic integrated circuits of optical phased arrays and focal plane switched arrays. An outstanding challenge remains to simultaneously achieve a compact footprint, broad wavelength operation, and low power consumption. Here, we introduce a laser beam scanner that meets these requirements. Using microcantilevers embedded with silicon nitride nanophotonic circuitry, we demonstrate broadband, one- and two-dimensional steering of light with wavelengths from 410 nm to 700 nm. The microcantilevers have ultracompact ~0.1 mm$^2$ areas, consume ~31 to 46 mW of power, are simple to control, and emit a single light beam. The microcantilevers are monolithically integrated in an active photonic platform on 200-mm silicon wafers. The microcantilever-integrated photonic circuits miniaturize and simplify light projectors to enable versatile, power-efficient, and broadband laser scanner microchips.

Published
2022
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27. Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil

Author

Walter A. Boeger, Michel P. Valim, Hussam Zaher, José A. Rafael, Rafaela C. Forzza, Alexandre R. Percequillo, Cristiana S. Serejo, André R.S. Garraffoni, Adalberto J. Santos, Adam Slipinski, Adelita M. Linzmeier, Adolfo R. Calor, Adrian A. Garda, Adriano B. Kury, Agatha C.S. Fernandes, Aisur I. Agudo-Padrón, Alberto Akama, Alberto M. da Silva Neto, Alejandro L. Burbano, Aleksandra Menezes, Alessandre Pereira-Colavite, Alexander Anichtchenko, Alexander C. Lees, Alexandra M.R. Bezerra, Alexandre C. Domahovski, Alexandre D. Pimenta, Alexandre L.P. Aleixo, Alexandre P. Marceniuk, Alexandre S. de Paula, Alexandre Somavilla, Alexandre Specht, Alexssandro Camargo, Alfred F. Newton, Aline A.S. da Silva, Aline B. dos Santos, Aline D. Tassi, Allan C. Aragão, Allan P.M. Santos, Alvaro E. Migotto, Amanda C. Mendes, Amanda Cunha, Amazonas Chagas Júnior, Ana A.T. de Sousa, Ana C. Pavan, Ana C.S. Almeida, Ana L.B.G. Peronti, Ana L. Henriques-Oliveira, Ana L. Prudente, Ana L. Tourinho, Ana M.O. Pes, Ana P. Carmignotto, Ana P.G. da Silva Wengrat, Ana P.S. Dornellas, Anamaria Dal Molin, Anderson Puker, André C. Morandini, André da S. Ferreira, André L. Martins, André M. Esteves, André S. Fernandes, André S. Roza, Andreas Köhler, Andressa Paladini, Andrey J. de Andrade, Ângelo P. Pinto, Anna C. de A. Salles, Anne I. Gondim, Antonia C.Z. Amaral, Antonio A.A. Rondón, Antonio Brescovit, Antônio C. Lofego, Antonio C. Marques, Antonio Macedo, Artur Andriolo, Augusto L. Henriques, Augusto L. Ferreira Júnior, Aurino F. de Lima, Ávyla R. de A. Barros, Ayrton do R. Brito, Bárbara L.V. Romera, Beatriz M.C. de Vasconcelos, Benjamin W. Frable, Bernardo F. Santos, Bernardo R. Ferraz, Brunno B. Rosa, Brunno H.L. Sampaio, Bruno C. Bellini, Bruno Clarkson, Bruno G. de Oliveira, Caio C.D. Corrêa, Caleb C. Martins, Camila F. de Castro-Guedes, Camilla Souto, Carla de L. Bicho, Carlo M. Cunha, Carlos A. de M. Barboza, Carlos A.S. de Lucena, Carlos Barreto, Carlos D.C.M. de Santana, Carlos E.Q. Agne, Carlos G.C. Mielke, Carlos H.S. Caetano, Carlos H.W. Flechtmann, Carlos J.E. Lamas, Carlos Rocha, Carolina S. Mascarenhas, Cecilia B. Margaría, Cecilia Waichert, Celina Digiani, Célio F.B. Haddad, Celso O. Azevedo, Cesar J. Benetti, Charles M.D. dos Santos, Charles R. Bartlett, Cibele Bonvicino, Cibele S. Ribeiro-Costa, Cinthya S.G. Santos, Cíntia E.L. Justino, Clarissa Canedo, Claudia C. Bonecker, Cláudia P. Santos, Claudio J.B. de Carvalho, Clayton C. Gonçalves, Cleber Galvão, Cleide Costa, Cléo D.C. de Oliveira, Cristiano F. Schwertner, Cristiano L. Andrade, Cristiano M. Pereira, Cristiano Sampaio, Cristina de O. Dias, Daercio A. de A. Lucena, Daiara Manfio, Dalton de S. Amorim, Dalva L. de Queiroz, Daniara Colpani, Daniel Abbate, Daniel A. Aquino, Daniel Burckhardt, Daniel C. Cavallari, Daniel de C. Schelesky Prado, Daniel L. Praciano, Daniel S. Basílio, Daniela de C. Bená, Daniela G.P. de Toledo, Daniela M. Takiya, Daniell R.R. Fernandes, Danilo C. Ament, Danilo P. Cordeiro, Darliane E. Silva, Darren A. Pollock, David B. Muniz, David I. Gibson, David S. Nogueira, Dayse W.A. Marques, Débora Lucatelli, Deivys M.A. Garcia, Délio Baêta, Denise N.M. Ferreira, Diana Rueda-Ramírez, Diego A. Fachin, Diego de S. Souza, Diego F. Rodrigues, Diego G. de Pádua, Diego N. Barbosa, Diego R. Dolibaina, Diogo C. Amaral, Donald S. Chandler, Douglas H.B. Maccagnan, Edilson Caron, Edrielly Carvalho, Edson A. Adriano, Edson F. de Abreu Júnior, Edson H.L. Pereira, Eduarda F.G. Viegas, Eduardo Carneiro, Eduardo Colley, Eduardo Eizirik, Eduardo F. dos Santos, Eduardo M. Shimbori, Eduardo Suárez-Morales, Eliane P. de Arruda, Elisandra A. Chiquito, Élison F.B. Lima, Elizeu B. de Castro, Elton Orlandin, Elynton A. do Nascimento, Emanuel Razzolini, Emanuel R.R. Gama, Enilma M. de Araujo, Eric Y. Nishiyama, Erich L. Spiessberger, Érika C.L. dos Santos, Eugenia F. Contreras, Eunice A.B. Galati, Evaldo C. de Oliveira Junior, Fabiana Gallardo, Fabio A. Hernandes, Fábio A. Lansac-Tôha, Fabio B. Pitombo, Fabio Di Dario, Fábio L. dos Santos, Fabio Mauro, Fabio O. do Nascimento, Fabio Olmos, Fabio R. Amaral, Fabio Schunck, Fábio S. P. de Godoi, Fabrizio M. Machado, Fausto E. Barbo, Federico A. Agrain, Felipe B. Ribeiro, Felipe F.F. Moreira, Felipe F. Barbosa, Fenanda S. Silva, Fernanda F. Cavalcanti, Fernando C. Straube, Fernando Carbayo, Fernando Carvalho Filho, Fernando C.V. Zanella, Fernando de C. Jacinavicius, Fernando H.A. Farache, Fernando Leivas, Fernando M.S. Dias, Fernando Mantellato, Fernando Z. Vaz-de-Mello, Filipe M. Gudin, Flávio Albuquerque, Flavio B. Molina, Flávio D. Passos, Floyd W. Shockley, Francielly F. Pinheiro, Francisco de A.G. de Mello, Francisco E. de L. Nascimento, Francisco L. Franco, Francisco L. de Oliveira, Francisco T. de V. Melo, Freddy R.B. Quijano, Frederico F. Salles, Gabriel Biffi, Gabriel C. Queiroz, Gabriel L. Bizarro, Gabriela Hrycyna, Gabriela Leviski, Gareth S. Powell, Geane B. dos Santos, Geoffrey E. Morse, George Brown, George M.T. Mattox, Geraldo Zimbrão, Gervásio S. Carvalho, Gil F.G. Miranda, Gilberto J. de Moraes, Gilcélia M. Lourido, Gilmar P. Neves, Gilson R.P. Moreira, Giovanna G. Montingelli, Giovanni N. Maurício, Gláucia Marconato, Guilherme E.L. Lopez, Guilherme L. da Silva, Guilherme Muricy, Guilherme R.R. Brito, Guilherme S.T. Garbino, Gustavo E. Flores, Gustavo Graciolli, Gustavo S. Libardi, Heather C. Proctor, Helcio R. Gil-Santana, Henrique R. Varella, Hermes E. Escalona, Hermes J. Schmitz, Higor D.D. Rodrigues, Hilton de C. Galvão Filho, Hingrid Y.S. Quintino, Hudson A. Pinto, Hugo L. Rainho, Igor C. Miyahira, Igor de S. Gonçalves, Inês X. Martins, Irene A. Cardoso, Ismael B. de Oliveira, Ismael Franz, Itanna O. Fernandes, Ivan F. Golfetti, Ivanklin S. Campos-Filho, Ivo de S. Oliveira, Jacques H.C. Delabie, Jader de Oliveira, Jadila S. Prando, James L. Patton, Jamille de A. Bitencourt, Janaina M. Silva, Jandir C. Santos, Janine O. Arruda, Jefferson S. Valderrama, Jeronymo Dalapicolla, Jéssica P. Oliveira, Jiri Hájek, João P. Morselli, João P. Narita, João P.I. Martin, Jocélia Grazia, Joe McHugh, Jorge J. Cherem, José A.S. Farias Júnior, Jose A.M. Fernandes, José F. Pacheco, José L.O. Birindelli, José M. Rezende, Jose M. Avendaño, José M. Barbanti Duarte, José R. Inácio Ribeiro, José R.M. Mermudes, José R. Pujol-Luz, Josenilson R. dos Santos, Josenir T. Câmara, Joyce A. Teixeira, Joyce R. do Prado, Juan P. Botero, Julia C. Almeida, Julia Kohler, Julia P. Gonçalves, Julia S. Beneti, Julian P. Donahue, Juliana Alvim, Juliana C. Almeida, Juliana L. Segadilha, Juliana M. Wingert, Julianna F. Barbosa, Juliano Ferrer, Juliano F. dos Santos, Kamila M.D. Kuabara, Karine B. Nascimento, Karine Schoeninger, Karla M. Campião, Karla Soares, Kássia Zilch, Kim R. Barão, Larissa Teixeira, Laura D. do N.M. de Sousa, Leandro L. Dumas, Leandro M. Vieira, Leonardo H.G. Azevedo, Leonardo S. Carvalho, Leonardo S. de Souza, Leonardo S.G. Rocha, Leopoldo F.O. Bernardi, Letícia M. Vieira, Liana Johann, Lidianne Salvatierra, Livia de M. Oliveira, Lourdes M.A. El-moor Loureiro, Luana B. Barreto, Luana M. Barros, Lucas Lecci, Lucas M. de Camargos, Lucas R.C. Lima, Lucia M. Almeida, Luciana R. Martins, Luciane Marinoni, Luciano de A. Moura, Luciano Lima, Luciano N. Naka, Lucília S. Miranda, Lucy M. Salik, Luis E.A. Bezerra, Luis F. Silveira, Luiz A. Campos, Luiz A.S. de Castro, Luiz C. Pinho, Luiz F.L. Silveira, Luiz F.M. Iniesta, Luiz F.C. Tencatt, Luiz R.L. Simone, Luiz R. Malabarba, Luiza S. da Cruz, Lukas Sekerka, Lurdiana D. Barros, Luziany Q. Santos, Maciej Skoracki, Maira A. Correia, Manoel A. Uchoa, Manuella F.G. Andrade, Marcel G. Hermes, Marcel S. Miranda, Marcel S. de Araújo, Marcela L. Monné, Marcelo B. Labruna, Marcelo D. de Santis, Marcelo Duarte, Marcelo Knoff, Marcelo Nogueira, Marcelo R. de Britto, Marcelo R.S. de Melo, Marcelo R. de Carvalho, Marcelo T. Tavares, Marcelo V. Kitahara, Marcia C.N. Justo, Marcia J.C. Botelho, Márcia S. Couri, Márcio Borges-Martins, Márcio Felix, Marcio L. de Oliveira, Marco A. Bologna, Marco S. Gottschalk, Marcos D.S. Tavares, Marcos G. Lhano, Marcus Bevilaqua, Marcus T.T. Santos, Marcus V. Domingues, Maria A.M. Sallum, María C. Digiani, Maria C.A. Santarém, Maria C. do Nascimento, María de los A.M. Becerril, Maria E.A. dos Santos, Maria I. da S. dos Passos, Maria L. Felippe-Bauer, Mariana A. Cherman, Mariana Terossi, Marie L.C. Bartz, Marina F. de C. Barbosa, Marina V. Loeb, Mario Cohn-Haft, Mario Cupello, Marlúcia B. Martins, Martin L. Christofersen, Matheus Bento, Matheus dos S. Rocha, Maurício L. Martins, Melissa O. Segura, Melissa Q. Cardenas, Mércia E. Duarte, Michael A. Ivie, Michael M. Mincarone, Michela Borges, Miguel A. Monné, Mirna M. Casagrande, Monica A. Fernandez, Mônica Piovesan, Naércio A. Menezes, Natalia P. Benaim, Natália S. Reategui, Natan C. Pedro, Nathalia H. Pecly, Nelson Ferreira Júnior, Nelson J. da Silva Júnior, Nelson W. Perioto, Neusa Hamada, Nicolas Degallier, Ning L. Chao, Noeli J. Ferla, Olaf H.H. Mielke, Olivia Evangelista, Oscar A. Shibatta, Otto M.P. Oliveira, Pablo C.L. Albornoz, Pablo M. Dellapé, Pablo R. Gonçalves, Paloma H.F. Shimabukuro, Paschoal Grossi, Patrícia E. da S. Rodrigues, Patricia O.V. Lima, Paul Velazco, Paula B. dos Santos, Paula B. Araújo, Paula K.R. Silva, Paula R. Riccardi, Paulo C. de A. Garcia, Paulo G.H. Passos, Paulo H.C. Corgosinho, Paulo Lucinda, Paulo M.S. Costa, Paulo P. Alves, Paulo R. de O. Roth, Paulo R.S. Coelho, Paulo R.M. Duarte, Pedro F. de Carvalho, Pedro Gnaspini, Pedro G.B. Souza-Dias, Pedro M. Linardi, Pedro R. Bartholomay, Peterson R. Demite, Petr Bulirsch, Piter K. Boll, Rachel M.M. Pereira, Rafael A.P.F. Silva, Rafael B. de Moura, Rafael Boldrini, Rafaela A. da Silva, Rafaela L. Falaschi, Ralf T.S. Cordeiro, Ramon J.C.L. Mello, Randal A. Singer, Ranyse B. Querino, Raphael A. Heleodoro, Raphael de C. Castilho, Reginaldo Constantino, Reinaldo C. Guedes, Renan Carrenho, Renata S. Gomes, Renato Gregorin, Renato J.P. Machado, Renato S. Bérnils, Renato S. Capellari, Ricardo B. Silva, Ricardo Kawada, Ricardo M. Dias, Ricardo Siewert, Ricaro Brugnera, Richard A.B. Leschen, Robert Constantin, Robert Robbins, Roberta R. Pinto, Roberto E. dos Reis, Robson T. da C. Ramos, Rodney R. Cavichioli, Rodolfo C. de Barros, Rodrigo A. Caires, Rodrigo B. Salvador, Rodrigo C. Marques, Rodrigo C. Araújo, Rodrigo de O. Araujo, Rodrigo de V.P. Dios, Rodrigo Johnsson, Rodrigo M. Feitosa, Roger W. Hutchings, Rogéria I.R. Lara, Rogério V. Rossi, Roland Gerstmeier, Ronald Ochoa, Rosa S.G. Hutchings, Rosaly Ale-Rocha, Rosana M. da Rocha, Rosana Tidon, Rosangela Brito, Roseli Pellens, Sabrina R. dos Santos, Sandra D. dos Santos, Sandra V. Paiva, Sandro Santos, Sarah S. de Oliveira, Sávio C. Costa, Scott L. Gardner, Sebastián A. Muñoz Leal, Sergio Aloquio, Sergio L.C. Bonecker, Sergio L. de S. Bueno, Sérgio M. de Almeida, Sérgio N. Stampar, Sérgio R. Andena, Sergio R. Posso, Sheila P. Lima, Sian de S. Gadelha, Silvana C. Thiengo, Simone C. Cohen, Simone N. Brandão, Simone P. Rosa, Síria L.B. Ribeiro, Sócrates D. Letana, Sonia B. dos Santos, Sonia C.S. Andrade, Stephane Dávila, Stéphanie Vaz, Stewart B. Peck, Susete W. Christo, Suzan B.Z. Cunha, Suzete R. Gomes, Tácio Duarte, Taís Madeira-Ott, Taísa Marques, Talita Roell, Tarcilla C. de Lima, Tatiana A. Sepulveda, Tatiana F. Maria, Tatiana P. Ruschel, Thaiana Rodrigues, Thais A. Marinho, Thaís M. de Almeida, Thaís P. Miranda, Thales R.O. Freitas, Thalles P.L. Pereira, Thamara Zacca, Thaynara L. Pacheco, Thiago F. Martins, Thiago M. Alvarenga, Thiago R. de Carvalho, Thiago T.S. Polizei, Thomas C. McElrath, Thomas Henry, Tiago G. Pikart, Tiago J. Porto, Tiago K. Krolow, Tiago P. Carvalho, Tito M. da C. Lotufo, Ulisses Caramaschi, Ulisses dos S. Pinheiro, Ulyses F.J. Pardiñas, Valéria C. Maia, Valeria Tavares, Valmir A. Costa, Vanessa S. do Amaral, Vera C. Silva, Vera R. dos S. Wolff, Verônica Slobodian, Vinícius B. da Silva, Vinicius C. Espíndola, Vinicius da Costa-Silva, Vinicius de A. Bertaco, Vinícius Padula, Vinicius S. Ferreira, Vitor C.P. da Silva, Vítor de Q. Piacentini, Vivian E. Sandoval-Gómez, Vivian Trevine, Viviane R. Sousa, Vivianne B. de Sant’Anna, Wayne N. Mathis, Wesley de O. Souza, Wesley D. Colombo, Wioletta Tomaszewska, Wolmar B. Wosiacki, Ximena M.C. Ovando, and Yuri L.R. Leite

Subjects
Biodiversity, knowledge management, taxonomy, web services, zoology, Zoology, QL1-991
Abstract

ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others.

Published
2024
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28. Divergent folding-mediated epistasis among unstable membrane protein variants

Author

Laura M Chamness, Charles P Kuntz, Andrew G McKee, Wesley D Penn, Christopher M Hemmerich, Douglas B Rusch, Hope Woods, Dyotima, Jens Meiler, and Jonathan P Schlebach

Subjects
epistasis, membrane protein folding, protein misfolding, protein evolution, translocon, Medicine, Science, Biology (General), QH301-705.5
Abstract

Many membrane proteins are prone to misfolding, which compromises their functional expression at the plasma membrane. This is particularly true for the mammalian gonadotropin-releasing hormone receptor GPCRs (GnRHR). We recently demonstrated that evolutionary GnRHR modifications appear to have coincided with adaptive changes in cotranslational folding efficiency. Though protein stability is known to shape evolution, it is unclear how cotranslational folding constraints modulate the synergistic, epistatic interactions between mutations. We therefore compared the pairwise interactions formed by mutations that disrupt the membrane topology (V276T) or tertiary structure (W107A) of GnRHR. Using deep mutational scanning, we evaluated how the plasma membrane expression of these variants is modified by hundreds of secondary mutations. An analysis of 251 mutants in three genetic backgrounds reveals that V276T and W107A form distinct epistatic interactions that depend on both the severity and the mechanism of destabilization. V276T forms predominantly negative epistatic interactions with destabilizing mutations in soluble loops. In contrast, W107A forms positive interactions with mutations in both loops and transmembrane domains that reflect the diminishing impacts of the destabilizing mutations in variants that are already unstable. These findings reveal how epistasis is remodeled by conformational defects in membrane proteins and in unstable proteins more generally.

Published
2024
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29. Monolithically integrated, broadband, high-efficiency silicon nitride-on-silicon waveguide photodetectors in a visible-light integrated photonics platform

Author

Lin, Yiding, Yong, Zheng, Luo, Xianshu, Azadeh, Saeed Sharif, Mikkelsen, Jared, Sharma, Ankita, Chen, Hong, Mak, Jason C. C., Lo, Patrick G. -Q., Sacher, Wesley D., and Poon, Joyce K. S.

Subjects
Physics - Optics, Physics - Applied Physics
Abstract

Visible and near-infrared spectrum photonic integrated circuits are quickly becoming a key technology to address the scaling challenges in quantum information and biosensing. Thus far, integrated photonic platforms in this spectral range have lacked integrated photodetectors. Here, we report the first silicon nitride-on-silicon waveguide photodetectors that are monolithically integrated in a visible light photonic platform on silicon. Owing to a leaky-wave silicon nitride-on-silicon design, the devices achieved a high external quantum efficiency of > 60% across a record wavelength span from $\lambda$ ~400 nm to ~640 nm, an opto-electronic bandwidth up to 9 GHz, and an avalanche gain-bandwidth product up to 173 $\pm$ 30 GHz. As an example, a photodetector was integrated with a wavelength-tunable microring in a single chip for on-chip power monitoring., Comment: 20 pages, 21 figures

Published
2022
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31. Power-Efficient Silicon Nitride Thermo-Optic Phase Shifters for Visible Light

Author

Yong, Zheng, Chen, Hong, Luo, Xianshu, Govdeli, Alperen, Chua, Hongyao, Azadeh, Saeed S., Stalmashonak, Andrei, Lo, Guo-Qiang, Poon, Joyce K. S., and Sacher, Wesley D.

Subjects
Physics - Optics, Physics - Applied Physics
Abstract

We demonstrate power-efficient, thermo-optic, silicon nitride waveguide phase shifters for blue, green, and yellow wavelengths. The phase shifters operated with low power consumption due to a suspended structure and multi-pass waveguide design. The devices were fabricated on 200-mm silicon wafers using deep ultraviolet lithography as part of an active visible-light integrated photonics platform. The measured power consumption to achieve a $\pi$ phase shift (averaged over multiple devices) was 0.78, 0.93, 1.09, and 1.20 mW at wavelengths of 445, 488, 532, and 561 nm, respectively. The phase shifters were integrated into Mach-Zehnder interferometer switches, and $10- 90$\% rise(fall) times of about 570(590) $\mu$s were measured., Comment: Zheng Yong and Hong Chen contributed equally to this work

Published
2021
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33. Optical phased array neural probes for beam-steering in brain tissue

Author

Sacher, Wesley D., Chen, Fu-Der, Moradi-Chameh, Homeira, Liu, Xinyu, Almog, Ilan Felts, Lordello, Thomas, Chang, Michael, Naderian, Azadeh, Fowler, Trevor M., Segev, Eran, Xue, Tianyuan, Mahallati, Sara, Valiante, Taufik A., Moreaux, Laurent C., Poon, Joyce K. S., and Roukes, Michael L.

Subjects
Physics - Optics
Abstract

Implantable silicon neural probes with integrated nanophotonic waveguides can deliver patterned dynamic illumination into brain tissue at depth. Here, we introduce neural probes with integrated optical phased arrays and demonstrate optical beam steering in vitro. Beam formation in brain tissue was simulated and characterized. The probes were used for optogenetic stimulation and calcium imaging.

Published
2021
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34. Preparation and Characterization of Thin Arsenic Targets for Stacked-Target Experiments

Author

Voyles, Andrew S., Fox, Morgan B., Morrell, Jonathan T., Zach, Michael P., Still, Evan K., Bernstein, Lee A., Frey, Wesley D., and Mehciz, Burton J.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

Thin, uniform arsenic targets suitable for high-fidelity cross section measurements in stacked-target experiments were prepared by electrodeposition of arsenic on titanium backings from aqueous solutions. Electrolytic cells were constructed and capable of arsenic deposits ranging in mass from approximately 1$\unicode{x2013}$29 mg (0.32$\unicode{x2013}$7.2 mg/cm$^2$, 0.57$\unicode{x2013}$13 $\mu$m). Examination of electrodeposit surface morphology by scanning electron microscopy and microanalysis was performed to investigate the uniformity of produced targets. Brief studies of plating growth dynamics and structural properties through cyclic voltammetry were also undertaken. Alternative target fabrication approaches by vapor deposition and electrodeposition from a deep eutectic solvent were additionally conducted. We further introduce a non-destructive characterization method for thin targets by neutron activation, which is independent of neutron flux shape, environmental factors, and source geometry, while correcting for any potential scatter or absorption effects., Comment: 15 pages (+4 for references/acknowledgments), 11 figures, preprint prepared for NIM-B

Published
2021

36. Leveraging University Partnerships to Build Capacity in Rural Schools: A Case Study

Author

Hickey, Wesley D., Sherman, Ross, Mize, Cody, and Donley, Michael

Abstract

There are 339 schools in Texas that are struggling, defined as "improvement required" by the Texas Education Agency (TEA) (txschools.gov, 2018) and received a "F" rating due to low academic performance. This designation is earned through a formula that measures general student achievement, school progress based on a comparison of previous year's standardized test scores, and the ability to close the academic achievement gaps among student groups (TEA, 2018a). Of these "improvement required" schools, 201 are elementary, 71 are middle, and 56 are high school (TEA, 2018b). This data suggests there is significant need for strategies that turn around the academic performance of schools, and rural schools have fewer resources to utilize. Leveraging university partnerships is one way for a campus to get support for turnaround initiatives. This case study will look at a rural elementary campus that took the steps to become a school turnaround campus through a partnership with a local university.

Published
2019

45. Microcantilever-integrated photonic circuits for broadband laser beam scanning

Author

Saeed Sharif Azadeh, Jason C. C. Mak, Hong Chen, Xianshu Luo, Fu-Der Chen, Hongyao Chua, Frank Weiss, Christopher Alexiev, Andrei Stalmashonak, Youngho Jung, John N. Straguzzi, Guo-Qiang Lo, Wesley D. Sacher, and Joyce K. S. Poon

Subjects
Science
Abstract

Abstract Laser beam scanning is central to many applications, including displays, microscopy, three-dimensional mapping, and quantum information. Reducing the scanners to microchip form factors has spurred the development of very-large-scale photonic integrated circuits of optical phased arrays and focal plane switched arrays. An outstanding challenge remains to simultaneously achieve a compact footprint, broad wavelength operation, and low power consumption. Here, we introduce a laser beam scanner that meets these requirements. Using microcantilevers embedded with silicon nitride nanophotonic circuitry, we demonstrate broadband, one- and two-dimensional steering of light with wavelengths from 410 nm to 700 nm. The microcantilevers have ultracompact ~0.1 mm2 areas, consume ~31 to 46 mW of power, are simple to control, and emit a single light beam. The microcantilevers are monolithically integrated in an active photonic platform on 200-mm silicon wafers. The microcantilever-integrated photonic circuits miniaturize and simplify light projectors to enable versatile, power-efficient, and broadband laser scanner microchips.

Published
2023
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48. The Tenure Process: A Descriptive Study of Selected Texas Universities

Author

Miller, Gary and Hickey, Wesley D.

Abstract

Few things in the professional life of university faculty are more important than the tenure process. Achieving tenure provides the faculty member with the confidence that his or her position with the university will be secure for life. Politicians often criticize the tenure of teachers at all educational levels (Flaherty, 2017; Money, 2015). There is the shared belief among these groups that tenure provides a level of security that should not exist. The argument is that high achievement should be the final arbiter in determining whether a teacher, or professor, keeps his or her job, and termination of the educator ensues if productivity declines (Kahlenberg, 2016). This assertion resonates with many, but there are various reasons that tenure exists within higher education. Tenure is an important step in academia that allows for protection in researching and disseminating data on politically unpopular subjects. When academicians are able to expand conventional knowledge, even if it is uncomfortable to the public at-large, all benefit because the knowledge-base is expanded without concern for political and cultural pressures. The purpose of this study was to determine current tenure guidelines, as well as thoughts on what should be included, among deans, department chairs, and faculty in universities who have member participants in the Texas Council of Professors of Educational Administration organization. This descriptive analysis looked at the perception of each group on the role of teaching, scholarship, and service, and clarified differences in expectations based upon university position.

Published
2018

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