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11. MIDAS: Modulares Interaktives Datenbanksystem

Author

Wesch, H., Winkler, W., Leisner, T., Koller, S., editor, Reichertz, P. L., editor, Überla, K., editor, Anderson, J., editor, Goos, G., editor, Gremy, F., editor, Jesdinsky, H.-J., editor, Lange, H.-J., editor, Schneider, B., editor, Segmüller, G., editor, Wagner, G., editor, and Weidtman, V., editor

Published
1980
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12. Radiation-Induced Primary Liver Tumors in 'Thorotrast Patients'

Author

van Kaick, G., Wesch, H., Lührs, H., Liebermann, D., Herfarth, Ch., editor, Senn, H. J., editor, Baum, M., editor, Diehl, V., editor, von Essen, C., editor, Grundmann, E., editor, Hitzig, W., editor, Rajewsky, M. F., editor, Herfarth, Christian, editor, Schlag, Peter, editor, and Hohenberger, Peter, editor

Published
1986
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21. Apparative überwachung

Author

Leveno, K. J., Santos-Ramos, R., Duenhoelter, J. H., Whalley, P. J., Semm, K., Arabin, B., Hoffbauer, H., Terinde, R., Distler, W., Freundl, G., Herberger, J., Duenhoelter, J. H., Kelly, M., Santos-Ramos, R., Schmidt, W., Gabelmann, J., Paulski, H., Wesch, H., Huber, H., Kubli, F., Duenhoelter, J. H., Santos-Ramos, R., Reisch, J. S., Schlensker, K. -H., Bolte, A., Breuker, K. -H., Hickl, E. -J., Bandilla, P., Busche, D., Rüttgers, H., Muliawan, D., Grothe, W., Kubli, F., Fendel, H., Cooreman, G., Jung, H., Renoldi, A., Brandt, H., Seisler, M., Kamps, H. U., Fischer, W. M., Becker, V., Richter, R., Hohl, M., Lüscher, K., Stucki, D., Stude, I., Ekert, W. D., Fischer, W. M., Garoff, L., Schmidt, W., Kubli, F., Schlotter, C. M., Jäger, E., Bögelspacher, H. R., Stein, W. W., Wentz, M., Rücker, K., Herbertz, D., Steinhart, R., Garoff, L., Schmidt, W., Kubli, F., Schuhmann, R., Halberstadt, E., Fortmeyer, H. P., Schuhmann, R., Sauer, H., Halberstadt, E., Granitzka, S., Berger, C., Ramzin, M., Baumann, U., Richter, R., Roemer, V. M., Heinzl, S., Peters, F. D., Klöck, F. -K., Kiefer-Kwadynski, M., Lamberti, G., Junge, H. D., v. Hagens, C., Rüttgers, H., Boos, R., Muliawan, D., Kubli, F., Dorsch, J., Stude, I., Fischer, W. M., Muliawan, D., Rüttgers, H., Boos, R., Kubli, F., Schlotter, C. M., Bögelspacher, H. R., Hammacher, K., Müller, R., Sipos, S., Benthin, D., and Höpken, W.

Published
1979
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38. Cancer 1

Author

McElvenny, D., primary, Armstrong, B. G., additional, Kirkham, T. L., additional, Demers, P. A., additional, McLeod, C., additional, Tamburic, L., additional, Koehoorn, M., additional, Ahn, Y. S., additional, Jung, S. Y., additional, Bochmann, F., additional, Taeger, D., additional, Krahn, U., additional, Wiethege, T., additional, Ickstadt, K., additional, Johnen, G., additional, Eisenmenger, A., additional, Wesch, H., additional, Bruening, T., additional, Pesch, B., additional, Tse, L. A., additional, Yu, I. T. S., additional, Sapkota, A., additional, Hashibe, M., additional, Gajalakshmi, V., additional, Jetly, D., additional, Roychowdhury, S., additional, Dikshit, R., additional, Brennan, P., additional, Boffetta, P., additional, Robinson, C. F., additional, Sullivan, P. A., additional, and Walker, J. T., additional

Published
2007
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50. Antitumoral activity of a sulphur-containing platinum complex with an acidic pH optimum.

Author

Amtmann, Eberhard, Zöller, Margot, Wesch, Horst, Schilling, Gerhard, Amtmann, E, Zöller, M, Wesch, H, and Schilling, G

Subjects
ANTINEOPLASTIC agents, CANCER treatment, DRUG side effects, CANCER cells, SMALL cell lung cancer, DNA, PLASMIDS, CANCER chemotherapy, LEUKEMIA, DNA metabolism, ANIMALS, BONE marrow, CELLS, CHEMICAL reagents, CISPLATIN, COLON tumors, CLINICAL drug trials, HYDROGEN-ion concentration, LUNG tumors, MICE, RECTUM tumors, ORGANOPLATINUM compounds, SARCOMA, SULFUR compounds, XENOGRAFTS, SMALL cell carcinoma, THERAPEUTICS
Abstract

Unlabelled: Platinum complexes are essential tools for cancer treatment despite their toxic side effects. Here we describe a new platinum complex with sulphurs as complexing atoms (thioplatin).Purpose: To demonstrate that the antitumoral activity of a new sulphur-containing platinum compound (thioplatin) depends on a slightly acidic pH.Methods: Platinum uptake by tumour cells and interaction with DNA was determined at slightly acidic or alkaline pH. To demonstrate low in vivo toxicity the effects of thioplatin on body weight, blood urea nitrogen, white blood cell count and the histopathological appearance of small intestines and kidneys were evaluated at doses that displayed antitumoral effects against human small-cell lung cancer and human colorectal cancer xenotransplants in nude mice.Results: The slightly acidic pH optimum of thioplatin was proven by the altered electrophoretic mobility of plasmid DNA, quantitation of the platinum content in the DNA of tumour cells and cytotoxicity studies. Thioplatin displayed antitumoral activity without severe side effects such as weight loss, renal ischaemia, destruction of villi in the small intestine or leukopenia as observed at comparable doses of cisplatin. Furthermore, probably due to its lipophilic nature, thioplatin was taken up readily even by cisplatin-resistant cells. In vivo studies with human tumour xenografts in nude mice showed a therapeutic index of thioplatin five to ten times higher than that of cisplatin. [ABSTRACT FROM AUTHOR]

Published
2001
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