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1. Ordre public exceptions for algorithmic surveillance patents

Author

Wernick, Alina

Subjects
Computer Science - Computers and Society, Computer Science - Artificial Intelligence
Abstract

This chapter explores the role of patent protection in algorithmic surveillance and whether ordre public exceptions from patentability should apply to such patents, due to their potential to enable human rights violations. It concludes that in most cases, it is undesirable to exclude algorithmic surveillance patents from patentability, as the patent system is ill-equipped to evaluate the impacts of the exploitation of such technologies. Furthermore, the disclosure of such patents has positive externalities from the societal perspective by opening the black box of surveillance for public scrutiny., Comment: 14 pages

Published
2024
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8. Post-acute COVID-19 outcomes including participant-reported long COVID: amubarvimab/romlusevimab versus placebo in the ACTIV-2 trialResearch in context

Author

Teresa H. Evering, Carlee Moser, Nikolaus Jilg, Justin Ritz, David A. Wohl, Jonathan Z. Li, David Margolis, Arzhang Cyrus Javan, Joseph J. Eron, Judith S. Currier, Eric S. Daar, Davey M. Smith, Michael D. Hughes, Kara W. Chew, Kara Chew, David (Davey) Smith, Eric Daar, David Wohl, Judith Currier, Joseph Eron, Michael Hughes, Mark Giganti, Lara Hosey, Jhoanna Roa, Nilam Patel, Kelly Colsh, Irene Rwakazina, Justine Beck, Scott Sieg, Jonathan Li, Courtney Fletcher, William Fischer, Rachel Bender Ignacio, Sandra Cardoso, Katya Corado, Prasanna Jagannathan, Alan Perelson, Sandy Pillay, Cynthia Riviere, Upinder Singh, Babafemi Taiwo, Joan Gottesman, Matthew Newell, Susan Pedersen, Joan Dragavon, Cheryl Jennings, Brian Greenfelder, William Murtaugh, Jan Kosmyna, Morgan Gapara, Akbar Shahkolahi, Verónica Lacal, Diego Salusso, Sebastian Nuñez, Marcelo Rodrigo Rodriguez, Luciana Laborde, Marcelo Papasidero, Luis Wehbe, Mariana Gonzalez, Felicitas Fernandez Voena, Tomas Alvarez, Amaru Lopez, Virginia Huhn, Ulises D'Andrea Nores, Pablo Dieser, Fernando Bordese, Marisa Mussi, Rodrigo de Carvalho Santana, Adriana Aparecida Tiraboschi Bárbaro, Breno Santos, Rita de Cássia Alves Lira, Andre Luiz Machado da Silva, Sandra Wagner Cardoso, Maria Pia Diniz Ribeiro, Nathália Soliva, Eduardo Vasconcellos, Jorge Eurico Ribeiro, Miriam Amaral Enéas, Jorge Pinto, Julia Fonseca de Morais Caporali, Flávia Gomes Faleiro Ferreira, Norma Erendira Rivera Martinez, Victor Casildo Bohorquez Lopez, Melchor Victor Frias, Krystle Fetalvero, Alyxzza Maranan, Jennifer Rosa, Thomas Coetzer, Maureen Mohata, Sr., Umesh Lalloo, Penelope Madlala, Larisha Pillay-Ramaya, Jaclyn Ann Bennet, Noluthando Mwelase, Nokuphiwa Mbhele, Frederick Petrick, Leonard Joubert, Rose Mbali, Sr., Natasha Joseph, Mmatsie Manentsa, Eugene van der Walt, Mduduzi Sandile Lawrance Masilela, Zinhle Zwane, Tendai Chiperera, Lerato Mohapi, Suri Moonsamy, Usha Singh, Kirsten McHarry, Elizma Snyman, Pieter Lennox, James Craig Innes, Oteng Letlape, Olebogeng Jonkane, William Brumskine, Tania Adonis, Ni Ni Sein, Modulakgotla Sebe, Yacoob Vahed, Nazreen Jeewa Hussen, Ismail Mitha, Vasundhara Cheekati, Purna Cheekati, Christie Lummus, Samuel Idarraga, Andrew Kim, David N. Pham, Wei-Hsin Kao, Michael M. Pfeffer, Miriam Batule Dominguez, Anju Malik, Anna Bryan, Melanie Arnold, Idania Fernandez, Cinzia Karpf, Aniuska Ruiz, David Taylor, Eric Folkens, Jennifer Manne, Sigal Yawetz, Cheryl Keenan, Emeka Eziri, Carl Fichtenbaum, Jenifer Baer, Sarah Trentman, Robert Call, Leroy Vaughan, Aaron Milstone, Jamie Alex Slandzicki, Jessica Wallan, Clinton Guillory, Nancy Andrews, Leslie Hughes, Jonathan Berardi, Celine Arar, Randall Quinn, Jorge P. Amaya, Marissa Gomez-Martinez, Luis Cantu, Monica Betancourt-Garcia, Nwora Lance Okeke, Charles M. Burns, Fadi Haddad, Victoria Haddad, Augusto Focil, Griselda Rosas, Susana Moyano, Yaneicy Gonzalez Rojas, Ahmad Aswad, Yevgeniy Bukhman, Manish Jain, Eugene Bukhman, Humam Farah, Rebekah McClain, Sadia Shaik, Timothy Hatlen, Deepa Gotur, Joseph Surber, Jeffrey Kingsley, April Pixler, Alex Zopo, Jack Herman, Craig Herman, Ramon Leon, Boris Nikolov, Fernando Gonzalez Vergara, Ana I. Gonzalez, Noemi Gonzalez, Michael Gelman, Olga Andriunas, Zarema Jagizarov, Jan Westerman, David Davis, Donna Sherer, Kelly Dooley, Becky Becker, Adaliah Wilkins, Jose Pérez, Eloy Roman, Heriberto Fernández, Bharat Mocherla, Kelly Beck, Valarie Maldonado, Jennifer Veltman, Rajesh Gandhi, Katrina Shea, Matthew Planchon, Laura Bogan Herpel, Kaushlendra K. Tripathi, Donald C. Day, John Pullman, Sr., Erin Williams-Leber, Misty Johnson, Michelle Hecker, Ann Avery, Keila Hoover, George W. Monlux, Elizabeth Juneja, Jr., Arthur Wernick, Karelia Ruiz, Maureen Hernández, Yadilys Pérez, Babafemi O. Taiwo, Claudia Hawkins, Baiba Berzins, Carlos Malvestutto, Heather Harber, Robyn Cicarella, Edwin DeJesus, Charlotte-Paige Rolle, Almena L. Free, Sallie D. Pulliam, Debra Weinstein, Rosa M. Suarez, Ezequiel Socorro, Estefania Socorro, Gene Neytman, Raymond Easley, Mariam Aziz, Joan Swiatek, Avish Nagpal, Breanna Kompelien, Kathryn McEvoy, Susan E. Hoover, Allison Lutz, Jessica Just, Manuel Hernandez, Yanly B. Victoria, Gabriel Rodriguez, Divya Pathak, Joshua J. Ordway, Megan Heffner, Patrick Weston, Khalilah Weston, Madhu Choudhary, Jennifer Sullivano, Olayemi Osiyemi, Myriam Izquierdo, Odelsey Torna, Brian Clemency, Renoj Varughese, Joshua Lynch, Aleen Khodabakhshian, Samantha Fortier, Christopher Coyne, Alexandrea Cronin, Constance Benson, Steven Hendrickx, Rosemarie Ramirez, Anne Luetkemeyer, Suzanne Hendler, Dennis Dentoni-Lasofsky, Mobeen Rathore, Saniyyah Mahmoudi, Amna Riaz, Mario Castro, Leslie Spikes, Chase Hall, Jonathan Oakes, Amy James Loftis, Pablo Tebas, William Short, Michael P. Dube, Saahir Khan, Luis M. Mendez, Sarah McGuffin, Chris Jonsson, Mamta K. Jain, Smruthi Senthil, Kimberly Turner-Gray, Sanjay Mehta, Mary Lewinski, Masoud Azizad, Christopher Chow, Lisa Nakatani, Derrick Williamson, Hisham Atriss, Matthew Caloura, Midhun Malla, Hannah Hazard-Jenkins, Aimee Wilkin, Jamraus Fayssoux, Hannah Seagle, Rachel Presti, and Alem Haile

Subjects
COVID-19, Monoclonal antibodies, Outpatient treatment, Clinical trial, Post COVID conditions, Long COVID, Medicine (General), R5-920
Abstract

Summary: Background: It is unknown if early COVID-19 monoclonal antibody (mAb) therapy can reduce risk of Long COVID. The mAbs amubarvimab/romlusevimab were previously demonstrated to reduce risk of hospitalization/death by 79%. This study assessed the impact of amubarvimab/romlusevimab on late outcomes, including Long COVID. Methods: Non-hospitalized high-risk adults within 10 days of COVID-19 symptom onset enrolled in a randomized, double-blind, placebo-controlled phase 2/3 trial of amubarvimab/romlusevimab for COVID-19 treatment. Late symptoms, assessed using a participant-completed symptom diary, were a pre-specified exploratory endpoint. The primary outcome for this analysis was the composite of Long COVID by participant self-report (presence of COVID-19 symptoms as recorded in the diary at week 36) or hospitalization or death by week 36. Inverse probability weighting (IPW) was used to address incomplete outcome ascertainment, giving weighted risk ratios (wRR) comparing amubarvimab/romlusevimab to placebo. Findings: Participants received amubarvimab/romlusevimab (n = 390) or placebo (n = 390) between January and July 2021. Median age was 49 years, 52% were female, 18% Black/African American, 49% Hispanic/Latino, and 9% COVID-19-vaccinated at entry. At week 36, 103 (13%) had incomplete outcome ascertainment, and 66 (17%) on amubarvimab/romlusevimab and 92 (24%) on placebo met the primary outcome (wRR = 0.70, 95% confidence interval (CI) 0.53–0.93). The difference was driven by fewer hospitalizations/deaths with amubarvimab/romlusevimab (4%) than placebo (13%). Among 652 participants with available diary responses, 53 (16%) on amubarvimab/romlusevimab and 44 (14%) on placebo reported presence of Long COVID. Interpretation: Amubarvimab/romlusevimab treatment, while highly effective in preventing hospitalizations/deaths, did not reduce risk of Long COVID. Additional interventions are needed to prevent Long COVID. Funding: National Institute of Allergy and Infectious Diseases of the National Institutes of Health. Amubarvimab and romlusevimab supplied by Brii Biosciences.

Published
2024
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9. Observer studies of image quality of denoising reduced-count cardiac single photon emission computed tomography myocardial perfusion imaging by three-dimensional Gaussian post-reconstruction filtering and deep learning

Author

Pretorius, P. Hendrik, Liu, Junchi, Kalluri, Kesava S., Jiang, Yulei, Leppo, Jeffery A., Dahlberg, Seth T., Kikut, Janusz, Parker, Matthew W., Keating, Friederike K., Licho, Robert, Auer, Benjamin, Lindsay, Clifford, Konik, Arda, Yang, Yongyi, Wernick, Miles N., and King, Michael A.

Published
2023
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11. Surviving the Strain of Youth Organizing: Youth and Organizational Responses

Author

DeBower, Jenny, Ortega-Williams, Anna, Wernick, Laura J., Brathwaite, Brittany, and Rodriguez, Miguel

Abstract

Youth of Color in the United States are often leaders in movements for social justice. Evidence suggests that organizing has a positive macro-therapeutic effect on the mental health of young organizers; however, they can also experience strain and become targets of the very systems they are trying to change. In a community-based participatory action research study, three organizations that train youth of Color in organizing in Brooklyn, New York City held focus groups with youth and adult staff. The focus groups examined the strains experienced by youth organizers and the strategies adult partners use to prepare organizers to maintain hope and well-being. Findings suggest four key emergent strategies: (a) provide an emotional homespace to process the rub between worlds, (b) actively shape the long view on systems change, (c) increase self-care skills and emotional preparation for organizing, and (d) promote healing by building leader(full) communities.

Published
2023
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14. Post-acute COVID-19 outcomes including participant-reported long COVID: amubarvimab/romlusevimab versus placebo in the ACTIV-2 trial

Author

Chew, Kara, Smith, David (Davey), Daar, Eric, Wohl, David, Currier, Judith, Eron, Joseph, Javan, Arzhang Cyrus, Hughes, Michael, Moser, Carlee, Giganti, Mark, Ritz, Justin, Hosey, Lara, Roa, Jhoanna, Patel, Nilam, Colsh, Kelly, Rwakazina, Irene, Beck, Justine, Sieg, Scott, Li, Jonathan, Fletcher, Courtney, Fischer, William, Evering, Teresa H., Ignacio, Rachel Bender, Cardoso, Sandra, Corado, Katya, Jagannathan, Prasanna, Jilg, Nikolaus, Perelson, Alan, Pillay, Sandy, Riviere, Cynthia, Singh, Upinder, Taiwo, Babafemi, Gottesman, Joan, Newell, Matthew, Pedersen, Susan, Dragavon, Joan, Jennings, Cheryl, Greenfelder, Brian, Murtaugh, William, Kosmyna, Jan, Gapara, Morgan, Shahkolahi, Akbar, Margolis, David, Lacal, Verónica, Salusso, Diego, Nuñez, Sebastian, Rodriguez, Marcelo Rodrigo, Laborde, Luciana, Papasidero, Marcelo, Wehbe, Luis, Gonzalez, Mariana, Voena, Felicitas Fernandez, Alvarez, Tomas, Lopez, Amaru, Huhn, Virginia, D'Andrea Nores, Ulises, Dieser, Pablo, Bordese, Fernando, Mussi, Marisa, de Carvalho Santana, Rodrigo, Tiraboschi Bárbaro, Adriana Aparecida, Santos, Breno, de Cássia Alves Lira, Rita, Machado da Silva, Andre Luiz, Cardoso, Sandra Wagner, Diniz Ribeiro, Maria Pia, Soliva, Nathália, Vasconcellos, Eduardo, Ribeiro, Jorge Eurico, Enéas, Miriam Amaral, Pinto, Jorge, Fonseca de Morais Caporali, Julia, Faleiro Ferreira, Flávia Gomes, Rivera Martinez, Norma Erendira, Bohorquez Lopez, Victor Casildo, Frias, Melchor Victor, Fetalvero, Krystle, Maranan, Alyxzza, Rosa, Jennifer, Coetzer, Thomas, Mohata, Maureen, Sr., Lalloo, Umesh, Madlala, Penelope, Pillay-Ramaya, Larisha, Bennet, Jaclyn Ann, Mwelase, Noluthando, Mbhele, Nokuphiwa, Petrick, Frederick, Joubert, Leonard, Mbali, Rose, Sr., Joseph, Natasha, Manentsa, Mmatsie, van der Walt, Eugene, Lawrance Masilela, Mduduzi Sandile, Zwane, Zinhle, Chiperera, Tendai, Mohapi, Lerato, Moonsamy, Suri, Singh, Usha, McHarry, Kirsten, Snyman, Elizma, Lennox, Pieter, Innes, James Craig, Letlape, Oteng, Jonkane, Olebogeng, Brumskine, William, Adonis, Tania, Sein, Ni Ni, Sebe, Modulakgotla, Vahed, Yacoob, Hussen, Nazreen Jeewa, Mitha, Ismail, Cheekati, Vasundhara, Cheekati, Purna, Lummus, Christie, Idarraga, Samuel, Kim, Andrew, Pham, David N., Kao, Wei-Hsin, Pfeffer, Michael M., Dominguez, Miriam Batule, Malik, Anju, Bryan, Anna, Arnold, Melanie, Fernandez, Idania, Karpf, Cinzia, Ruiz, Aniuska, Taylor, David, Folkens, Eric, Manne, Jennifer, Yawetz, Sigal, Keenan, Cheryl, Eziri, Emeka, Fichtenbaum, Carl, Baer, Jenifer, Trentman, Sarah, Call, Robert, Vaughan, Leroy, Milstone, Aaron, Slandzicki, Jamie Alex, Wallan, Jessica, Guillory, Clinton, Andrews, Nancy, Hughes, Leslie, Berardi, Jonathan, Arar, Celine, Quinn, Randall, Amaya, Jorge P., Gomez-Martinez, Marissa, Cantu, Luis, Betancourt-Garcia, Monica, Okeke, Nwora Lance, Burns, Charles M., Haddad, Fadi, Haddad, Victoria, Focil, Augusto, Rosas, Griselda, Moyano, Susana, Rojas, Yaneicy Gonzalez, Aswad, Ahmad, Bukhman, Yevgeniy, Jain, Manish, Bukhman, Eugene, Farah, Humam, McClain, Rebekah, Shaik, Sadia, Hatlen, Timothy, Gotur, Deepa, Surber, Joseph, Kingsley, Jeffrey, Pixler, April, Zopo, Alex, Herman, Jack, Herman, Craig, Leon, Ramon, Nikolov, Boris, Vergara, Fernando Gonzalez, Gonzalez, Ana I., Gonzalez, Noemi, Gelman, Michael, Andriunas, Olga, Jagizarov, Zarema, Westerman, Jan, Davis, David, Sherer, Donna, Dooley, Kelly, Becker, Becky, Wilkins, Adaliah, Pérez, Jose, Roman, Eloy, Fernández, Heriberto, Mocherla, Bharat, Beck, Kelly, Maldonado, Valarie, Veltman, Jennifer, Gandhi, Rajesh, Shea, Katrina, Planchon, Matthew, Herpel, Laura Bogan, Tripathi, Kaushlendra K., Day, Donald C., Pullman, John, Sr., Williams-Leber, Erin, Johnson, Misty, Hecker, Michelle, Avery, Ann, Hoover, Keila, Monlux, George W., Juneja, Elizabeth, Jr., Wernick, Arthur, Ruiz, Karelia, Hernández, Maureen, Pérez, Yadilys, Taiwo, Babafemi O., Hawkins, Claudia, Berzins, Baiba, Malvestutto, Carlos, Harber, Heather, Cicarella, Robyn, DeJesus, Edwin, Rolle, Charlotte-Paige, Free, Almena L., Pulliam, Sallie D., Weinstein, Debra, Suarez, Rosa M., Socorro, Ezequiel, Socorro, Estefania, Neytman, Gene, Easley, Raymond, Aziz, Mariam, Swiatek, Joan, Nagpal, Avish, Kompelien, Breanna, McEvoy, Kathryn, Hoover, Susan E., Lutz, Allison, Just, Jessica, Hernandez, Manuel, Victoria, Yanly B., Rodriguez, Gabriel, Pathak, Divya, Ordway, Joshua J., Heffner, Megan, Weston, Patrick, Weston, Khalilah, Choudhary, Madhu, Sullivano, Jennifer, Osiyemi, Olayemi, Izquierdo, Myriam, Torna, Odelsey, Clemency, Brian, Varughese, Renoj, Lynch, Joshua, Khodabakhshian, Aleen, Fortier, Samantha, Coyne, Christopher, Cronin, Alexandrea, Benson, Constance, Hendrickx, Steven, Ramirez, Rosemarie, Luetkemeyer, Anne, Hendler, Suzanne, Dentoni-Lasofsky, Dennis, Rathore, Mobeen, Mahmoudi, Saniyyah, Riaz, Amna, Castro, Mario, Spikes, Leslie, Hall, Chase, Oakes, Jonathan, Loftis, Amy James, Tebas, Pablo, Short, William, Dube, Michael P., Khan, Saahir, Mendez, Luis M., McGuffin, Sarah, Jonsson, Chris, Jain, Mamta K., Senthil, Smruthi, Turner-Gray, Kimberly, Mehta, Sanjay, Lewinski, Mary, Azizad, Masoud, Chow, Christopher, Nakatani, Lisa, Williamson, Derrick, Atriss, Hisham, Caloura, Matthew, Malla, Midhun, Hazard-Jenkins, Hannah, Wilkin, Aimee, Fayssoux, Jamraus, Seagle, Hannah, Presti, Rachel, Haile, Alem, Wohl, David A., Li, Jonathan Z., Eron, Joseph J., Currier, Judith S., Daar, Eric S., Smith, Davey M., Hughes, Michael D., and Chew, Kara W.

Published
2024
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15. Attending to Process in Teacher Education: Small but Impactful Changes to the Teacher Supervision System

Author

Wilhelm, Anne Garrison, Wernick, Ann Marie, and Young, Murphy K.

Abstract

This narrative case study describes the use of improvement science methods to strengthen the effectiveness of field experiences for teacher candidates. As part of a networked improvement community, we sought to reduce variation in the quality of field experience by providing a cohesive network of high-quality coaching supports. Using design-based methods grounded in the principles of improvement, we analyzed seven learning, design, and testing rounds to reduce variation in teacher candidates' experiences as student teachers or interns. Results from early learning rounds suggested considerable structural variability in how supervisors conducted their POP cycles. The structural variability from these rounds led to two key change ideas to address variation in teacher candidates field experiences: a common POP cycle protocol and the use of a POP-cycle-aligned reflection form. The principles and tools of improvement highlighted small but significant changes to how supervisors support teachers within their field experiences.

Published
2023
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17. Stability of vitamin A at critical points in pet-feed manufacturing and during premix storage

Author

Gabriela Miotto Galli, Ines Andretta, Nicolas Martinez, Bruno Wernick, Yauheni Shastak, Alvaro Gordillo, and Jaqueline Gobi

Subjects
dog, feed, processing, stability, vitamin, Veterinary medicine, SF600-1100
Abstract

The objective of this research was to assess and quantify the potential vitamin A losses that occur during the manufacturing of pet feed and premix, as well as during their extended storage periods. This trial was conducted at a commercial feeder mill that utilized a standard commercial dog feed along with a corresponding vitamin-mineral premix. The calculated amount of vitamin A supplemented in the feed, in addition to the endogenous vitamins present in the ingredients, was adjusted to 18,000 IU/kg of feed. Five 500 g feed samples were collected at each of the predefined critical points throughout the manufacturing process (after mixing, milling, preconditioner, and extrusion/drying processes) to verify the stability of vitamin A during feed production. Additionally, various samples were collected at regular intervals of 30, 60, 90, 120, and 180 days during the storage of the premix to assess the stability of vitamin A. Vitamin A analyses in the samples were performed using high-performance liquid chromatography. The variables were assessed for normality using the Shapiro–Wilk test, followed by analysis of variance (ANOVA) and Tukey’s test to compare the differences between the manufacturing process and premix shelf life. The statistical significance was set at 95%. The vitamin losses during the pre-conditioning process were 26%, and during the extrusion-drying processes, the losses were 34% when compared to the initial analyzed value. However, no differences were observed in other processes. There were no significant differences observed in recovered vitamin levels in the premix during its shelf-life (p = 0.484). The study indicated that the primary vitamin A losses in pet feed manufacturing processes occur during the pre-conditioning and drying/extrusion steps. However, it is worth noting that no significant losses of vitamin A were found during the premix storage phase.

Published
2024
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19. Effects of Replacing Inorganic with Organic Glycinates Trace Minerals on Growth Performance, Gut Function, and Minerals Loss of Juvenile Nile Tilapia

Author

Allan Vinnicius Urbich, Thais Pereira da Cruz, Bruno Wernick, Ibrahim Adeshina, Aline Victoria Sampaio, Giovani Sampaio Gonçalves, Adriana Yuriko Koga Kozu, Leandro Cavalcante Lipinski, Valéria Rossetto Barriviera Furuya, and Wilson Massamitu Furuya

Subjects
Aquaculture. Fisheries. Angling, SH1-691
Abstract

This study aimed to investigate the effects of replacing inorganic trace minerals (ITM) with organic trace minerals (OTM) on growth performance, body composition, gut histomorphometry, digestive enzyme activity, apparent digestibility coefficients (ADC), and mineral balance in juvenile Nile tilapia, Oreochromis niloticus. Fish (n = 432; 2.5 ± 0.5 g) were randomly distributed into four groups with four replicates each (27 fish per replicate). A control diet (gross 15.2 MJ gross energy kg−1; 367.3 g crude protein kg−1) was elaborated to meet the dietary requirements of zinc (Zn), manganese (Mn), and copper (Cu) using ITM in the sulfate form (ITM100). From the control diet, three diets were elaborated using OTM to supply 100% (OTM100), 75% (OTM75), and 50% (OTM50) of Zn, Mn, and Cu ITM of the control diet, respectively, supplied in the glycinate form. Fish were hand-fed six times daily for 8 weeks. Growth performance was not changed by dietary treatments. Fish fed on the diet OTM50 showed higher whole-body and vertebrae ash contents and higher whole-body calcium (Ca), Zn, and iron (Fe) retention than those fed on the control diet. The activity of digestive enzymes and the ADC of energy and nutrients, including Zn, Mn, and Cu, were similar in fish fed on diets OTM50 and ITM100. A reduction in Zn (−39.8%), Mn (−11.1%), and Cu (−14.0%) loss was observed in fish fed on the diet OTM50 than in fish fed diet ITM100. The dietary treatments did not affect the gut histomorphometry. In conclusion, the inclusion of OTM in Nile tilapia’s diets represents a promising strategy to reduce 50% of ITM sources by utilizing Zn, Mn, and Cu OTM as glycinates without detrimental effects on growth performance, nutrient utilization, and gut function. These results additionally reinforce the environmental benefits of using OTM for precise mineral nutrition in aquaculture.

Published
2024
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21. Tail-Cone Thruster Fan Rotor Flutter Analysis

Author

Akiva R Wernick and Milind A Bakhle

Subjects
Aircraft Propulsion and Power
Abstract

The aeroelastic stability of a tail cone thruster fan was analyzed for three structural modes and various nodal diameter patterns. Computational fluid dynamics modeling with blade vibrations was used in the analyses performed at design (peak-efficiency) and two near-stall conditions at the design rotational speed. Aerodynamic damping was used to assess flutter since this integrally bladed rotor design will have minimal structural damping. Aerodynamic damping was found to be low at the design condition. For the first mode, aerodynamic damping was seen to decrease towards stall, vanishing for a zero nodal diameter pattern. Further decrease in mass flow led to negative aerodynamic damping (flutter) for the first and second nodal diameters in the near stall condition. The flowfield at this lowest mass flow rate exhibited some additional unsteadiness at higher frequency. The sensitivity of results to time step and amplitudes of vibration was examined and found to be very satisfactory. The largest uncertainty in the results comes from the observed sensitivity of the aerodynamic damping to details of the variation of grid deformations in the blade passage mesh from the blade passage to the boundaries. For the parametric variations analyzed, the calculated aerodynamic damping is lower if the grid deformations near the blade surface are higher. Further work is needed to understand the cause of this sensitivity and find possible solutions to reduce the effects on flutter predictions.

Published
2024

22. Pivoting, Partnering, and Sensemaking: How Teachers Navigate the Transition to Remote Teaching Together

Author

Conry, Jillian M., Wernick, Ann M., and Ware, Paige

Abstract

Across the globe, the emergence of COVID-19 led to widespread, sudden suspension of in-person instruction, displacing more than 1.5 billion learners (Capilla et al., 2020). Addressing the gap in research on emergency remote teaching (ERT), this empirical study draws on insights from semi-structured interviews with 10 in-service and five pre-service teachers, who navigated the transition both as K-12 teachers and graduate students, participating in weekly mentoring for English language learners, online curricular modules, face-to-face discussions (until the transition to ERT), mixed-reality simulation teaching with coaching, and written reflections. Using a sensemaking theoretical framework, our study examines the following questions: (1) What were the main challenges and opportunities of ERT as experienced by this cohort of language teachers? (2) How did the dual role of being a K-12 teacher and graduate student provide a unique lens for navigating these challenges and opportunities? (3) What tools or supports helped these language teachers through the transition to ERT? Thematic analysis revealed three themes (emotion, shared meaning, and technology) and illuminated connection as an overarching theme. Findings suggest that the experience of navigating the transition from both positions led to greater empathy, increased facility using technology, and a growing support network of fellow teacher-learners.

Published
2022
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23. A REIMAGINED CAMPUS: BRISTOL AGGIE INVESTS IN THE FUTURE

Author

Wernick, Laura

Subjects
High schools -- Forecasts and trends, Technical education -- Forecasts and trends, Career education -- Forecasts and trends, Agricultural education -- Forecasts and trends, Market trend/market analysis, Education
Abstract

Aproject team of education stakeholders in Massachusetts gained tremendous knowledge about inclusion and student engagement as they worked to complete a 196,000-square-foot construction project. Bristol County Agricultural High School (Bristol [...]

Published
2023

24. Modelling the Political Context in Requirements Engineering. The System is made for Man, not Man for the System

Author

Siadati, Rana, Wernick, Paul, and Veneziano, Vito

Subjects
Computer Science - Software Engineering
Abstract

This paper describes the authors point of view on reaching a stage at which it is necessary to understand customer organizations better to identify their problems and how to address them. To resolve this issue we need a mechanism to capture and model how that organization actually operates by mapping organizations against the system to be developed, by including power and politics in their "too human" and even emotional dimension. We then describe here a notation by which to recognize and document power, politics and the emotional aspects of software requirements-related decision-making in customer organizations. We conclude by outlining that our suggested graphical notation would maybe not solve the problem: but even if it just raises awareness, this would make us closer to solving the problem. Given the sensibility of the political issue, it is assumed that the generated diagram using the above mentioned notations is only for the requirements engineer and his/her team, thus remaining strictly private., Comment: 7 pages, includes figures, contact details, references

Published
2019

26. Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity

Author

Choi, Minee L., Chappard, Alexandre, Singh, Bhanu P., Maclachlan, Catherine, Rodrigues, Margarida, Fedotova, Evgeniya I., Berezhnov, Alexey V., De, Suman, Peddie, Christopher J., Athauda, Dilan, Virdi, Gurvir S., Zhang, Weijia, Evans, James R., Wernick, Anna I., Zanjani, Zeinab Shadman, Angelova, Plamena R., Esteras, Noemi, Vinokurov, Andrey Y., Morris, Katie, Jeacock, Kiani, Tosatto, Laura, Little, Daniel, Gissen, Paul, Clarke, David J., Kunath, Tilo, Collinson, Lucy, Klenerman, David, Abramov, Andrey Y., Horrocks, Mathew H., and Gandhi, Sonia

Published
2022
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30. Effect of xylanase and β-glucanase on growth performance, activity of digestive enzymes, digestibility, and microbiome diversity of juvenile Nile tilapia fed soybean meal and/or sorghum distillers dried grains with solubles-based diets

Author

de Macêdo, Élison Silva, Urbich, Allan Vinnicius, Nakamura, Jessica Sayuri Ticse, da Cruz, Thais Pereira, Panaczevicz, Paola Aparecida Paulovski, Wernick, Bruno, Furuya, Valéria Rossetto Barriviera, Pezzato, Luiz Edivado, Gatlin, Delbert Monroe, III, and Furuya, Wilson Massamitu

Published
2023
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31. Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons

Author

Gurvir S. Virdi, Minee L. Choi, James R. Evans, Zhi Yao, Dilan Athauda, Stephanie Strohbuecker, Raja S. Nirujogi, Anna I. Wernick, Noelia Pelegrina-Hidalgo, Craig Leighton, Rebecca S. Saleeb, Olga Kopach, Haya Alrashidi, Daniela Melandri, Jimena Perez-Lloret, Plamena R. Angelova, Sergiy Sylantyev, Simon Eaton, Simon Heales, Dmitri A. Rusakov, Dario R. Alessi, Tilo Kunath, Mathew H. Horrocks, Andrey Y. Abramov, Rickie Patani, and Sonia Gandhi

Subjects
Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Mutations in the SNCA gene cause autosomal dominant Parkinson’s disease (PD), with loss of dopaminergic neurons in the substantia nigra, and aggregation of α-synuclein. The sequence of molecular events that proceed from an SNCA mutation during development, to end-stage pathology is unknown. Utilising human-induced pluripotent stem cells (hiPSCs), we resolved the temporal sequence of SNCA-induced pathophysiological events in order to discover early, and likely causative, events. Our small molecule-based protocol generates highly enriched midbrain dopaminergic (mDA) neurons: molecular identity was confirmed using single-cell RNA sequencing and proteomics, and functional identity was established through dopamine synthesis, and measures of electrophysiological activity. At the earliest stage of differentiation, prior to maturation to mDA neurons, we demonstrate the formation of small β-sheet-rich oligomeric aggregates, in SNCA-mutant cultures. Aggregation persists and progresses, ultimately resulting in the accumulation of phosphorylated α-synuclein aggregates. Impaired intracellular calcium signalling, increased basal calcium, and impairments in mitochondrial calcium handling occurred early at day 34–41 post differentiation. Once midbrain identity fully developed, at day 48–62 post differentiation, SNCA-mutant neurons exhibited mitochondrial dysfunction, oxidative stress, lysosomal swelling and increased autophagy. Ultimately these multiple cellular stresses lead to abnormal excitability, altered neuronal activity, and cell death. Our differentiation paradigm generates an efficient model for studying disease mechanisms in PD and highlights that protein misfolding to generate intraneuronal oligomers is one of the earliest critical events driving disease in human neurons, rather than a late-stage hallmark of the disease.

Published
2022
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36. Theory

Author

Wernick, Alina, Drexl, Josef, Series Editor, Hilty, Reto M., Series Editor, and Wernick, Alina

Published
2021
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40. Conclusions

Author

Wernick, Alina, Drexl, Josef, Series Editor, Hilty, Reto M., Series Editor, and Wernick, Alina

Published
2021
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41. Introduction

Author

Wernick, Alina, Drexl, Josef, Series Editor, Hilty, Reto M., Series Editor, and Wernick, Alina

Published
2021
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42. Concerto for cello and ten players ; Piano trio no. 1 ; Sextet

Author

Wernick, Richard, 1934- composer., Container of (work): Wernick, Richard, 1934- Sextet, piano, violins (2), viola, cello, double bass., Container of (work): Wernick, Richard, 1934- Concertos, cello, instrumental ensemble., and Container of (work): Wernick, Richard, 1934- Trios, piano, violin, cello, no. 1.

Published
2016

46. Future-proofing the city: A human rights-based approach to governing algorithmic, biometric and smart city technologies

Author

Alina Wernick and Anna Artyushina

Subjects
Smart cities, Governance, Biometric, Algorithmic governance, Human rights, Cybernetics, Q300-390, Information theory, Q350-390
Abstract

While the GDPR and other EU laws seek to mitigate a range of potential harms associated with smart cities, the compliance with and enforceability of these regulations remain an issue. In addition, these proposed regulations do not sufficiently address the collective harms associated with the deployment of biometric technologies and artificial intelligence. Another relevant question is whether the initiatives put forward to secure fundamental human rights in the digital realm account for the issues brought on by the deployment of technologies in city spaces. In this special issue, we employ the smart city notion as a point of connection for interdisciplinary research on the human rights implications of the algorithmic, biometric and smart city technologies and the policy responses to them. The articles included in the special issue analyse the latest European regulations as well as soft law, and the policy frameworks that are currently at work in the regions where the GDPR does not apply.

Published
2023
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47. Do European smart city developers dream of GDPR-free countries? The pull of global megaprojects in the face of EU smart city compliance and localisation costs

Author

Alina Wernick, Emeline Banzuzi, and Alexander Mörelius-Wulff

Subjects
Smart cities, Human rights, Data protection by design, GDPR, Technology export, Cybernetics, Q300-390, Information theory, Q350-390
Abstract

Smart city technologies can have detrimental effects on human rights, making it crucial to mitigate them in the R&D phase. This qualitative socio-legal study of the Helsinki metropolitan area (HMA) explores how public funding for smart city research and development (R&D), and the data protection by design principle (DPbD) of the General Data Protection Regulation (GDPR), facilitate the development of human rights compliant technology. Our study shows that the tension between the neoliberal logic of smart cities and that human rights compliance extends from the local to the global level. High compliance and localisation costs, one-sided inputs and a push for scalability in smart city technology development in Finland and other EU states may attract companies to overlook human rights risks and pursue markets outside the EU with lower standards of respect for human rights and the rule of law. We propose policy measures to facilitate human rights compliant smart city R&D, localisation and procurement, and discuss human rights due diligence and export control measures as means to mitigate the potential adverse effects of smart city technology exported from the EU. The study contributes to research on human rights-based approaches to smart city technology development and European innovation and export policy, with attention given to the role of public R&D funding agencies.

Published
2023
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48. Proximalization through one incision of a wrist arteriovenous fistula and distal revascularization with interval ligation

Author

Andre Rafizadeh, MD, Thomas Lee, MD, Kevin James, MD, and Brian Wernick, MD

Subjects
DRIL, Ischemic steal, Proximalization, Radiocephalic fistula, Ulcer, Surgery, RD1-811, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

In the setting of ischemic steal syndrome with tissue loss, patients with radiocephalic fistulas have limited options to preserve their conduit and treat their ischemic symptoms. To address this, we have proposed the technique of proximalization through one incision of a wrist arteriovenous fistula (POWR) with distal revascularization with interval ligation (DRIL) procedure. In the present retrospective, single-center, case series, we evaluated the outcomes of three patients with radiocephalic fistulas who had undergone POWR DRIL from 2017 to 2021. Their ischemic symptoms were monitored for regression. All three patients showed signs of regressing ischemia. The POWR DRIL represents an efficient procedure to address tissue loss and preserve the autogenous conduit.

Published
2023
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49. Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons

Author

Virdi, Gurvir S., Choi, Minee L., Evans, James R., Yao, Zhi, Athauda, Dilan, Strohbuecker, Stephanie, Nirujogi, Raja S., Wernick, Anna I., Pelegrina-Hidalgo, Noelia, Leighton, Craig, Saleeb, Rebecca S., Kopach, Olga, Alrashidi, Haya, Melandri, Daniela, Perez-Lloret, Jimena, Angelova, Plamena R., Sylantyev, Sergiy, Eaton, Simon, Heales, Simon, Rusakov, Dmitri A., Alessi, Dario R., Kunath, Tilo, Horrocks, Mathew H., Abramov, Andrey Y., Patani, Rickie, and Gandhi, Sonia

Published
2022
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50. Modelling politics in requirements engineering: adding emoji to existing notations

Author

Siadati, Rana, Wernick, Paul, and Veneziano, Vito

Subjects
Computer Science - Software Engineering, D.2.1, K.4.3, K.7
Abstract

Notwithstanding several authors have recognised the conceptual key of "politics" as an important component in any Require-ments Engineering (RE) process, practitioners still lack a prag-matic answer on how to deal with the political dimension: such an ability has become a mostly desirable but totally undetailed part of what we usually and vaguely refer to as "professional experience". Nor were practitioners given any suitable tool or method to easily detect, represent, control and if possible leverage politics. Authors argue that this issue could be successfully ad-dressed and resolved if, when we map organisations against the system to be developed, we include power and politics in their "too human" and even emotional dimension. A simple way to do so is to use emoji pictograms: most of them are part of a universal language, which requirements engineers could easily adopt and exploit to assess and produce models that include an extra layer of "political" information, without the need to actually introduce any new notation. A few examples of emoji-aware UML and organisational charts are hereby proposed, more as a platform to support communication and share reflections on how to deal with politics than as an actual technology to be adopted.

Published
2017

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