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ZusammenfassungDieser Übersichtsartikel befasst sich mit biomechanischen Testungen zur Verankerung von Pedikelschrauben an der thorakolumbalen Wirbelsäule. Es werden verschiedene Verfahren zu Testungen von Gesamtkonstruktionen sowie einzelner Pedikelschrauben erörtert. Im Weiteren werden Ergebnisse bereits durchgeführter Testungen zur Verankerung von Pedikelschrauben diskutiert, in welchen gezeigt werden konnte, dass Adaptionen von Augmentationstechniken und Verbesserungen des Pedikelschraubendesign einen vorteilhaften Einfluss auf die Schraubenverankerung haben. Biomechanische Studien stellen somit ein wichtiges Bindeglied zwischen Entwicklung und Klinik dar.

ZusammenfassungDie lumbale Spinalkanalstenose (LSS) ist eine häufige Wirbelsäulenerkrankung des älteren Patienten mit steigender sozioökonomischer Bedeutung. Derzeit gelten die uni- oder bilaterale Dekompression und die unilaterale Dekompression mit Unterschneidung (auch „undercutting“ oder „over the top“ Dekompression) von der ipsilateralen Zugangsseite zur kontralateralen Seite in Europa als Goldstandard zur Behandlung der lumbalen Spinalkanalstenose. Eine ausgedehnte Dekompression nervaler Strukturen birgt jedoch einige bekannte Nachteile, wie z.B. das Risiko einer sekundären lumbalen Instabilität. In den hier präsentierten Untersuchungen war es das Ziel, die Zunahme des segmentalen Bewegungsumfangs in Abhängigkeit vom Ausmaß einer Dekompression zu untersuchen. An 10 humanen „fresh-frozen“ Lendenwirbelsäulen wurden 4 sequenzielle, und in ihrem Umfang zunehmende Dekompressionen durchgeführt. Nach jeder erfolgten Dekompression wurden die Präparate in einem Wirbelsäulensimulator in Flexion-Extension, lateraler Beugung und axialer Rotation untersucht. Zusammengefasst konnte gezeigt werden, dass die unilaterale Dekompression, als auch die unilaterale Dekompression mit kontralateraler Unterschneidung zu keiner wesentlichen Zunahme des Bewegungsumfangs führte, wohingegen die Laminektomie einen deutlichen Anstieg des Bewegungsumfanges, insbesondere bei axialer Rotation, aufwies. Dies wiederum stellt ein erhöhtes Risiko für die Entstehung einer sekundären lumbalen Instabilität dar. Das aktuelle Fehlen klarer evidenzbasierter Leitlinien für die optimale chirurgische Therapie der lumbalen Spinalkanalstenose, ob mit oder ohne lumbaler Fusion, kann zur Über- oder Unterbehandlung bestimmter Patient:innen führen. Ob die statistisch signifikante Zunahme des Bewegungsumfangs auch einen Einfluss auf das klinische Ergebnis hat, und wie gefährdete Patient:innen identifiziert werden können sollte in weiteren Studien untersucht werden.

Purpose Stabilization of C1-2 using a Harms–Goel construct with 3.5 mm titanium (Ti) rods has been established as a standard of reference (SOR). A reduction in craniocervical deformities can indicate increased construct stiffness at C1-2. A reduction in C1-2 can result in C1-2 joint gapping. Therefore, the authors sought to study the biomechanical consequences of C1-2 gapping on construct stiffness using different instrumentations, including a novel 6-screw/3-rod (6S3R) construct, to compare the results to the SOR. We hypothesized that different instrument pattern will reveal significant differences in reduction in ROM among constructs tested. Methods The range of motion (ROM) of instrumented C1-2 polyamide models was analyzed in a six-degree-of-freedom spine tester. The models were loaded with pure moments (2.0 Nm) in axial rotation (AR), flexion extension (FE), and lateral bending (LB). Comparisons of C1-2 construct stiffness among the constructs included variations in rod diameter (3.5 mm vs. 4.0 mm), rod material (Ti. vs. CoCr) and a cross-link (CLX). Construct stiffness was tested with C1-2 facets in contact (Contact Group) and in a 2 mm distracted position (Gapping Group). The ROM (°) was recorded and reported as a percentage of ROM (%ROM) normalized to the SOR. A difference > 30% between the SOR and the %ROM among the constructs was defined as significant. Results Among all constructs, an increase in construct stiffness up to 50% was achieved with the addition of CLX, particularly with a 6S3R construct. These differences showed the greatest effect for the CLX in AR testing and for the 6S3R construct in FE and AR testing. Among all constructs, C1-2 gapping resulted in a significant loss of construct stiffness. A protective effect was shown for the CLX, particularly using a 6S3R construct in AR and FE testing. The selection of rod diameter (3.5 mm vs. 4.0 mm) and rod material (Ti vs. CoCr) did show a constant trend but did not yield significance. Conclusion This study is the first to show the loss of construct stiffness at C1-2 with gapping and increased restoration of stability using CLX and 6S3R constructs. In the correction of a craniocervical deformity, nuances in the surgical technique and advanced instrumentation may positively impact construct stability.

Many axial and appendicular skeleton bones are subjected to repetitive loading during daily activities. Until recently, the structural analysis of fractures has been limited to 2D sections, and the dynamic assessment of fracture progression has not been possible. The structural failure was analyzed using step-wise micro-compression combined with time-lapsed micro-computed tomographic imaging. The structural failure was investigated in four different sample materials (two different bone surrogates, lumbar vertebral bodies from bovine and red deer). The samples were loaded in different force steps based on uniaxial compression tests. The micro-tomography images were used to create three-dimensional models from which various parameters were calculated that provide information about the structure and density of the samples. By superimposing two 3D images and calculating the different surfaces, it was possible to precisely analyze which trabeculae failed in which area and under which load. According to the current state of the art, bone mineral density is usually used as a value for bone quality, but the question can be raised as to whether other values such as trabecular structure, damage accumulation, and bone mineralization can predict structural competence better than bone mineral density alone.

Background The aim of the current biomechanical study was to investigate a newly developed surgical technique for mallet fingers. The new method is based on the Ishiguro method which requires a K-wire through the distal interphalangeal joint for temporary fixation. The new technique avoids the joint trans fixation using a specially designed finger nail holder. This method was compared to the established Ishiguro's technique. Methods For biomechanical testing, 32 paired, fresh-frozen human fingers (Digit II–V) of 4 donors (ages 60 to 71 years) were used. The paired fingers were assigned to either the new method or Ishiguro's technique. The biomechanical testing consisted of a cyclic cantilever bending (2000 cycles, 1–7N) followed by a load to failure test. The groups were evaluated for plastic deformation, stiffness, change in stiffness during cyclic loading, subluxation and failure load by analysing force-deflect data and fluoroscopic images. Findings The nail fixation group showed significantly higher failure loads and stiffness than the trans fixation group. The values of plastic deformation were significantly lower in the nail fixation group. No differences were found in the change of stiffness. No subluxation was found in both groups. Interpretation In the current biomechanical study, nail fixation performed at least as good as Ishiguro's trans fixation technique. The results and ease of implementation indicate that the newly developed nail fixation technique might be a useful treatment method in daily clinical practice without the need of temporary joint trans-fixation avoiding possible associated problems. To establish this method, clinical trials will be necessary.

In the healthcare environment, bandage systems are versatile medical devices to position and fix patients’ torsos or extremities. In this study, the mechanical and morphological properties of an innovative patient position system, iFix, were assessed and compared to two commercially available bandages. Morphological properties were investigated using a scanning electron microscope (SEM). The iFix bandage showed anisotropic mechanical properties, with a more rigid behavior in the longitudinal direction and a more elastic behavior in the transverse direction. This behavior results from the organization of the fibers visible in the SEM images. All three materials investigated in this study were able to support similar maximum loads. In cases where a rigid fixation of patient limbs or torso is necessary, the authors recommend the usage of iFix. In vivo studies should be carried out to prove safety in a surgical environment before its clinical usage.

Spinal deformity is an abnormality in the spinal curves and can seriously affect the activities of daily life. The conventional way to treat spinal deformities, such as scoliosis, kyphosis, and spondylolisthesis, is to use spinal orthoses (braces). Braces have been used for centuries to apply corrective forces to the spine to treat spinal deformities or to stabilize the spine during postoperative rehabilitation. Braces have not modernized with advancements in technology, and very few braces are equipped with smart sensory design and active actuation. There is a need to enable the orthotists, ergonomics practitioners, and developers to incorporate new technologies into the passive field of bracing. This article presents a review of the conventional passive braces and highlights the advancements in spinal orthoses in terms of improved sensory designs, active actuation mechanisms, and new construction methods (CAD/CAM, three-dimensional (3D) printing). This review includes 26 spinal orthoses, comprised of passive rigid/soft braces, active dynamics braces, and torso training devices for the rehabilitation of the spine.

Introduction The fixation of the coracoid process onto the glenoid is an important step of the Latarjet procedure, and implant-associated complications are a relevant and severe problem. This study compares the fixation strength and failure mode of two biodegradable materials with stainless-steel screws. Methods 24 Fresh-frozen cadaveric scapulae were divided into three groups of equal size and received a coracoid transfer. Cadavers were matched according to their bone mineral density (BMD). In group 1, small-fragment screws made of stainless steel were used. In the second group, magnesium screws were used, and in the third group, screws consisted of polylactic acid (PLLA). A continuously increasing sinusoidal cyclic compression force was applied until failure occurred, which was defined as graft displacement relative to its initial position of more than 5 mm. Results At 5-mm displacement, the axial force values showed a mean of 374 ± 92 N (range 219–479 N) in group 1 (steel). The force values in group 2 (magnesium) had a mean of 299 ± 57 N (range 190–357 N). In group 3 (PLLA), failure occurred at 231 ± 83 N (range 109–355 N). The difference between group 1 (steel) and group 2 (magnesium) was not statistically significant (P = 0.212), while the difference between group 1 (steel) and group 3 (PLLA) was significant (P = 0.005). Conclusion Stainless-Steel screws showed the highest stability. However, all three screw types showed axial force values of more than 200 N. Stainless steel screws and PLLA screws showed screw cut-out as the most common failure mode, while magnesium screws showed screw breakage in the majority of cases. Evidence Controlled laboratory study.

In recent years, an increase in periprosthetic femur fractures has become apparent due to the increased number of hip replacements. In the case of Vancouver type B1 fractures, locking plate systems offer safe procedures. This study compared the distal lateral femur plate (LOQTEQ®, aap Implantate AG) with a standard L.I.S.S. LCP® (DePuy Synthes) regarding their biomechanical properties in fixation of periprosthetic femur fractures after hip arthroplasty. We hypothesized that the new LOQTEQ system has superior stability and durability in comparison. Eighteen artificial left femurs were randomized in two groups (Group A: LOQTEQ®; Group B: L.I.S.S. LCP®) and tested until failure. Failure was defined as 10° varus deformity and catastrophic implant failure (loosening, breakage, progressive bending). Axial stiffness, loads of failure, cycles of failure, modes of failure were recorded. The axial stiffness in Group A with 73.4 N/mm (SD +/− 3.0) was significantly higher (p = 0.001) than in Group B (40.7 N/mm (SD +/− 2.8)). Group A resists more cycles than Group B until 10° varus deformity. Catastrophic failure mode was plate breakage in Group A and bending in Group B. In conclusion, LOQTEQ® provides higher primary stability and tends to have higher durability.

Biomechanical investigation. Cervical two-level corpectomies with anterior-only instrumentation are associated with a high rate of implant-related complications. These procedures, therefore, often require an additional dorsal instrumentation to prevent screw loosening. Cement augmentation of the anterior screws in two-level corpectomies might stabilize the construct, so that a second dorsal procedure could be avoided. To evaluate the screw anchorage in cervical anterior-only procedures, an ex vivo evaluation of the range of motion (ROM) in two-level corpectomies (C4 and C5), with and without cement augmentation of the anterior screws, was carried out in this study. Twelve human cervical cadaveric spines (C2–T1) were divided into two groups of six specimens each. Corpectomies were performed in C4 and C5, with grafting and anterior instrumentation with and without cement augmentation of the anterior screw-and-plate system (0.3–0.5 mL cement/screw). Flexibility tests with pure moments (1.5 Nm) were carried out before and after three cyclic loading periods of 5000 cycles with increasing eccentric forces (100, 200, and 300 N). After corpectomy and instrumentation, the control group and the augmented group showed a significant reduction in ROM in comparison with the native states with average ROMs of 49% (±17%) and 24% (±10%), respectively (P = 0.006). The ROM in the control group increased significantly in all motion directions in the course of cyclic loading and approached native values after the third cyclic loading period, with an overall ROM of 78% (±22%). In contrast, the augmented group maintained a significantly decreased ROM in all motion directions during cyclic loading, with a final ROM of 32% (±14%) after the third period of cyclic testing. Inter-group comparison demonstrated a significant difference between the two groups in the course of cyclic loading. The cement-augmented group outperformed the control group in all motion directions, with a significantly lower ROM after all three cyclic loading periods. A two-level corpectomy with cement-augmentation results in a significantly reduced ROM. In comparison with the conventional anterior screw-and-plate fixation, it represents a significantly stabilized two-level anterior construct. This might be a treatment option for patients with a two-level corpectomy associated with reduced bone mineral density, to avoid an additional dorsal instrumentation.

To investigate if the stability of minimally invasive screw osteosynthesis of displaced intra-articular calcaneal fractures (DIACF) can be effectively increased by an innovative approach to screw tip augmentation. In eight-paired human cadaver hindfoot specimens, DIACF of Sanders type IIB were treated with either standard screw osteosynthesis or with bone cement augmentation of the screw tips in the main fragments. The instrumented specimens were subjected to a cyclic loading protocol (9000 cycles, with stepwise increasing loads, 100–1000 N). The interfragment motions were quantified as tuber fragment tilt (TFT) and posterior facet inclination angle (PFIA) using a 3-D motion analysis system. Bohler’s angle (BA) was evaluated from X-rays. A load-to-failure test was performed after the cyclic loading protocol. All but one specimen of the augmented group withstood more cycles than the respective specimens of the non-augmented group. Mean cycles to failure for the failure criterion of 5° TFT were 7299 ± 1876 vs. 3864 ± 1810, corresponding to loads of 811 N ± 195 vs. 481 N ± 180, (P = 0.043). There were no significant differences observed in the PFIAs. The failure criterion of 5° BA was reached after a mean of 7929 cycles ± 2004 in the augmented group and 4129 cycles ± 2178 in the non-augmented group, corresponding to loads of 893 N ± 200 vs. 513 N ± 218, (P = 0,090). The mean load-to-failure of the four specimens in the augmented group that completed the cyclic loading was 1969 N over a 1742–2483 N range. Screw tip augmentation significantly improved the mechanical stability of the calcanei after osteosynthesis in terms of decreased tuber fragment tilts and less changes in Bohler’s angle.

Biomechanical investigation. This study describes ex vivo evaluation of the range of motion (ROM) to characterize the stability and need for additional dorsal fixation after cervical single-level, two-level or multilevel corpectomy (CE) to elucidate biomechanical differences between anterior-only and supplemental dorsal instrumentation. Twelve human cervical cadaveric spines were loaded in a spine tester with pure moments of 1.5 Nm in lateral bending (LB), flexion/extension (FE), and axial rotation (AR), followed by two cyclic loading periods for three-level corpectomies. After each cyclic loading session, flexibility tests were performed for anterior-only instrumentation (group_1, six specimens) and circumferential instrumentation (group_2, six specimens). The flexibility tests for all circumferential instrumentations showed a significant decrease in ROM in comparison with the intact state and anterior-only instrumentations. In comparison with the intact state, supplemental dorsal instrumentation after three-level CE reduced the ROM to 12 % (±10 %), 9 % (±12 %), and 22 % (±18 %) in LB, FE, and AR, respectively. The anterior-only construct outperformed the intact state only in FE, with a significant ROM reduction to 57 % (±35 %), 60 % (±27 %), and 62 % (±35 %) for one-, two- and three-level CE, respectively. The supplemental dorsal instrumentation provided significantly more stability than the anterior-only instrumentation regardless of the number of levels resected and the direction of motion. After cyclic loading, the absolute differences in stability between the two instrumentations remained significant while both instrumentations showed a comparable increase of ROM after cyclic loading. The large difference in the absolute ROM of anterior-only compared to circumferential instrumentations supports a dorsal support in case of three-level approaches.

Biomedical Engineering / Biomedizinische Technik, 58 (Supplement 1), ISSN:0013-5585, ISSN:1862-278X

The Humerusblock NG represents a new semi-rigid angular stable fixation device for minimally invasive stabilization of proximal humeral fractures. This study evaluates the function and stability of the Humerusblock NG and its biomechanical properties on the basis of two different fracture models under cyclic loading. Six fresh frozen human humeri were tested in a dynamic shoulder joint abduction motion test bench, simulating abduction between 15° and 45°. A stable wedge fracture with intact medial hinge and an unstable fracture with 5-mm gap were loaded for 500 cycles. Radiological measurement of implant migration was performed. The stable fracture model showed a slow constant fracture settling. The unstable fracture model showed initial fracture settling with closure of the medial fracture gap during the first 20 cycles. Thereafter, a slow constant settling of the fracture was measured comparable to the stable fracture model. Maximum varus tilt was 3.17° for the stable and 3.68° for the unstable fracture pattern. Radiological analysis showed no change in the tip apex distance and a significant settling of the implants fixation pins in the unstable fracture model. None of the specimen failed during the testing. The Humerusblock NG allows for angular stable dynamic fixation of two-part proximal humeral fractures. It enables closure of the fracture gap and maintains fracture compression during loading, a concept already established in the stabilization of femoral neck fractures (dynamic hip screw). Clinical trials will be necessary to evaluate the value of this device in daily practice. Basic science study.

Most studies investigating cardiopulmonary resuscitation (CPR) interventions or functionality of mechanical CPR devices have been performed using porcine models. The purpose of this study was to identify differences between mechanical characteristics of the human and porcine chest during CPR.CPR data of 90 cardiac arrest patients was compared to data of 14 porcine from two animal studies. Chest stiffness k and viscosity mu were calculated from acceleration and pressure data recorded using a Laerdal Heartstart 4000SP defibrillator during CPR. K and mu were calculated at chest compression depths of 15, 30 and 50mm for three different time periods.At a depth of 15mm porcine chest stiffness was comparable to human chest stiffness at the beginning of resuscitation (4.8 vs. 4.5N/mm) and clearly lower after 200 chest compressions (2.9 vs. 4.5N/mm) (p0.05). At 30 and 50mm porcine chest stiffness was higher at the beginning and comparable to human chest stiffness after 200 chest compressions. After 200 chest compressions porcine chest viscosity was similar to human chest viscosity at 15mm (108 vs. 110Ns/m), higher for 30mm (240 vs. 188Ns/m) and clearly higher for 50mm chest compression depth (672 vs. 339Ns/m) (p0.05).In conclusion, human and porcine chest behave relatively similarly during CPR with respect to chest stiffness, but differences in chest viscosity at medium and deep chest compression depth should at least be kept in mind when extrapolating porcine results to humans.

The purpose of this study was to compare the stability of two established screw configurations (SC) for subtalar arthrodesis using a cyclic loading model. Eight paired human cadaver hindfoot specimens underwent subtalar arthrodesis with either parallel or angulated SC. The instrumented specimens were subjected to a cyclic loading protocol (1000 cycles: ±5 Nm rotation moment, 50 N axial force). The joint range of motion (ROM) was quantified before and after cyclic loading, in the three principal motion planes of the subtalar joint using pure bending moments of ±3 Nm. After instrumentation, the angulated SC showed significantly less mean ROM compared to the parallel SC in internal/external rotation (1.4° ± 2.2° vs. 3.3° ± 2.8°, P = 0.006) and in inversion/eversion (0.9° ± 1.4° vs. 1.5° ± 1.1°, P = 0.049). After cyclic loading, the angulated SC resulted in significantly less mean ROM compared to the parallel SC in internal/external rotation (3.3° ± 4.6° vs. 8.8° ± 8.0°, P = 0.006) and in inversion/eversion (1.9° ± 2.3° vs. 3.9° ± 3.9°, P = 0.017). No significant differences in the mean ROM were found between the angulated and parallel SC in dorsal extension/plantar flexion. The angulated SC resulted in decreased ROM in the subtalar arthrodesis construct after instrumentation and after cyclic loading compared to the parallel SC. The data from our study suggest that the clinical use of the angulated SC for subtalar arthrodesis might be superior to the parallel SC.

Background The aim of the current biomechanical cadaver study was to quantify the influence of an additional lag screw on construct stiffness in simple fracture models at the distal femur stabilised with a locking plate. Methods For biomechanical testing paired fresh frozen human femora of 5 donors (mean age: 71 (SD 9) years) were chosen. Different locking plate configurations either with or without interfragmentary lag screw were tested under torsional load (2/4 Nm/deg) or axial compression forces (500/1000 N). Findings Data show that plate constructs with interfragmentary lag screw reveal similar axial and torsional stiffness values compared to intact bone as opposed to bridging plate constructs that showed significantly lower stiffness for both loading conditions. Interpretation The current biomechanical testing unveils that the insertion of a lag screw combined with a locking plate dominates over a bridging plate construct at the distal femur in terms of axial and torsional stiffness.

STUDY DESIGN In vitro study to characterize the flexibility of a new total posterior-element system when instrumented to L4-L5 segments. OBJECTIVE The goal of this in vitro study was to investigate whether an optimized version of the TOPS implant (Impliant Ltd., Ramat Poleg, Israel) is capable to restore the physiologic motion characteristic of a spinal segment after facetectomy. SUMMARY OF BACKGROUND DATA The TOPS implant is designed to replace the posterior elements of a functional spinal unit, to provide flexible restabilization and spinal alignment, while maintaining the intervertebral disc. The implant is composed of bilateral pedicle screws, connected with 2 crossbars in the transversal plane. The crossbars are joined together by an elastic element capable of transmitting tensile and compressive loads, as well as shear forces. METHODS Six human cadaver specimens (L3-S1) (median age 61 years: minimum 47 and maximum 74 years) were used for this in vitro experiment. The specimens were loaded with pure moments of +/-7.5 Nm in flexion/extension, lateral bending, and axial rotation. The following states were investigated: (1) intact; (2) after bilateral laminectomy, including facetectomy of the lower facet joints, of the upper vertebra L4; and (3) after device implantation. The range of motion (ROM), neutral zone, and intradiscal pressure were determined from a third cycle. In a second step, the ROM in axial rotation was determined as a function of different flexion/extension postures. RESULTS In the neutral position, the laminectomy and facetectomy increased the median values of the ROM in flexion plus extension, lateral bending right plus left, and significantly in axial rotation left plus right from: 8.2 degrees, 7.6 degrees, 3.6 degrees to 12.1 degrees, 8.5 degrees, and 8.5 degrees (Wilcoxon signed rank test; P < 0.05). After fixation of the implant, the ROM was again reduced to 6.8 degrees, 7.8 degrees, and 3.8 degrees. In a flexed posture, the ROM in axial rotation was slightly increased compared to the neutral position. With increasing extension, the axial rotation decreased linearly from 3.7 degrees in neutral position to 2.3 degrees in 4 degrees extension in the segment L4-L5. The characteristic of the intradiscal pressure versus load with the implant was similar to that of the intact specimen. CONCLUSION The TOPS implant almost ideally restored the ROM in lateral bending and axial rotation compared to that of the intact specimen. In the sagittal plane, 85% of the intact ROM could be obtained. The ROM in axial rotation as a function of flexion and extension angle also mimics the biomechanical behavior of the posterior complex of a lumbar spine. This relationship between ROM and posture emphasizes the importance of a proper implantation.

The local interpretation of microfinite element (μFE) simulations plays a pivotal role for studying bone structure–function relationships such as failure processes and bone remodeling. In the past μFE simulations have been successfully validated on the apparent level, however, at the tissue level validations are sparse and less promising. Furthermore, intratrabecular heterogeneity of the material properties has been shown by experimental studies. We proposed an inverse μFE algorithm that iteratively changes the tissue level Young’s moduli such that the μFE simulation matches the experimental strain measurements. The algorithm is setup as a feedback loop where the modulus is iteratively adapted until the simulated strain matches the experimental strain. The experimental strain of human trabecular bone specimens was calculated from time-lapsed images that were gained by combining mechanical testing and synchrotron radiation microcomputed tomography (SRμCT). The inverse μFE algorithm was able to iterate the heterogeneous distribution of moduli such that the resulting μFE simulations matched artificially generated and experimentally measured strains.

Introduction Proximal humerus fracture fixation can be difficult because of osteoporosis making it difficult to achieve stable implant anchorage in the weak bone stock even when using locking plates. This may cause implant failure requiring revision surgery. Cement augmentation has, in principle, been shown to improve stability. The aim of this study was to investigate whether augmentation of particular screws of a locking plate aimed at a region of low bone quality is effective in improving stability in a proximal humerus fracture model. Materials and methods Twelve paired human humerus specimens were included. Quantitative computed tomography was performed to determine bone mineral density (BMD). Local bone quality in the direction of the six proximal screws of a standard locking plate (PHILOS, Synthes) was assessed using mechanical means (DensiProbe™). A three-part fracture model with a metaphyseal defect was simulated and fixed with the plate. Within each pair of humeri the two screws aimed at the region of the lowest bone quality according to the DensiProbe™ were augmented in a randomised manner. For augmentation, 0.5 ml of bone cement was injected in a screw with multiple outlets at its tip under fluoroscopic control. A cyclic varus-bending test with increasing upper load magnitude was performed until failure of the screw–bone fixation. Results The augmented group withstood significantly more load cycles. The correlation of BMD with load cycles until failure and BMD with paired difference in load cycles to failure showed that augmentation could compensate for a low BMD. Discussion and conclusion The results demonstrate that augmentation of screws in locked plating in a proximal humerus fracture model is effective in improving primary stability in a cyclic varus-bending test. The augmentation of two particular screws aimed at a region of low bone quality within the humeral head was almost as effective as four screws with twice the amount of bone cement. Screw augmentation combined with a knowledge of the local bone quality could be more effective in enhancing the primary stability of a proximal humerus locking plate because the effect of augmentation can be exploited more effectively limiting it to the degree required.

INTRODUCTION Previous data have shown that due to the technical ease, low-morbidity, and lower complication rates, the in situ single-implant fixation is the current standard for stabilization of slipped capital femoral epiphysis (SCFE) fixation. Multiple-implant fixation is thought to be combined with a higher incidence of serious complications. The purpose of the current study was to evaluate single- vs. multiple-implant fixation regarding strength and stiffness. Furthermore, different screw designs, including telescopic screw, were evaluated regarding the stiffness, strength, and especially fixation failure. METHODS Forty porcine proximal femurs were sectioned through the physeal line using a gigli saw and stabilized with a 7.3-mm stainless steel AO screw, a dynamic telescopic screw, three 1.6-mm Kirschner wires (K-wires), and three 2.0-mm K-wires. The femurs were biomechanically tested to determine failure load (N) and stiffness (N/mm). RESULTS No significant differences were found regarding failure load and stiffness between the two screw groups. The 2.0-mm K-wire construct was significantly the strongest and stiffest fixation. The 1.6-mm K-wire fixation had the lowest values, but not statistically significant. Regarding the fixation failure, no femoral shaft fracture occurred. CONCLUSION SCFE stabilization with three 2.0-mm K-wires leads to increased stability over single-screw fixation and 1.6-mm K-wire fixation. However, none of the two screws seemed to be superior in fixation stability and fixation failure.

This contribution deals with the simulation based investigation of processes related to the surgical treatment of vertebroplasty. In this regard, a simulation framework has been developed, which includes the generation of microstructural computer models of cancellous bone structures, the simulation of bone cement injection by computational fluid dynamics (CFD) methods and finite element (FE) simulations of bone cement curing processes. The modelling and computation strategy is illustrated and different material modelling approaches for the representation of acrylic bone cements as a non-linear fluid and a non-linear viscoelastic solid with curing dependent properties are outlined. (© 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim)