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Attention is influenced by information about relationships between ourselves and the objects around us. Self-related objects can either facilitate or disrupt task performance, creating a challenge for identifying the precise nature of the influence of self-relatedness on attention. To address this challenge, we measured different components of attention (alertness and orienting) in the presence of self-related objects using a revised attention network task (ANT). In a self-association task, participants first learned colour-person associations and then carried out a colour-person matching task. This was followed by the ANT, in which these coloured boxes associated with self or friend were displayed as peripheral cues; participants had to judge the direction of an arrow flanked by congruent (low-conflict) or incongruent (high-conflict) distractors presented within one coloured box. The results showed faster and more accurate responses to targets appearing within the self-colour than friend-colour cues in the association task. In the ANT, the analysis of alertness revealed that self-related cues facilitated task performance compared with friend-related cues. The analysis of orienting demonstrated that relative to friend cues, self-cues hampered task performance in invalid trials. Critically, the effects of self-cues on both orienting and alertness were observed only in high conflict situations. These results indicated that self-related objects are powerful cues that enhance attention intensity, which either facilitates task performance when the upcoming target falls within their location or disrupts performance when the target falls outside their location. The data suggest that attentional functions can be tuned by self-saliency in high-demand contexts.

Internet addiction (IA) is a common public health problem among college students, but little is known about the psychological mechanism of its relation to sense of coherence. This study extends previous literature by examining the associations between sense of coherence, psychological distress, escape motivation, and IA. Cluster random sampling is used to obtain a sample of Chinese college students (N = 4171, Mean age = 19.26, SD = 1.18) through an online survey. Data are analyzed by using structural equation modeling. Results indicate that sense of coherence not only directly predicts IA, but also indirectly affects IA through the mediators of psychological distress and escape motivation of Internet use. In particular, sense of coherence decreases the level of psychological distress (β = −0.639, p

Based on the social and psychological capital framework, this study aimed to investigate the direct effect of bullying on adolescents’ subjective well-being and to reveal the potential psychosocial mechanisms in this relationship. Through the multi-stage cluster random sampling procedure, a cross-sectional survey was conducted among 728 adolescents from Hebei Province in China. Structural equation modeling was adopted for data analysis. After controlling for sociodemographic variables, the results indicated that only relational bullying had a significant negative effect on adolescents’ subjective well-being. Moreover, social capital and psychological capital mediated the relationship between relational bullying and adolescents’ subjective well-being. This study expands our understanding of the influencing mechanisms from bullying victimization to subjective well-being and also provides practical implications for future social policy development and relevant interventions.

Objective. Knowledge, belief, and behavior model (knowledge-attitude-practice (KAP)) is known as a cognitive model. Health education is important to the prognosis of patients, including chronic obstructive pulmonary disease (COPD) patients. However, the investigation regarding health education based on the KAP model is few. Thus, this work is aimed at analyzing the influence of nurse-led health education on self-management ability, satisfaction, and compliance of elderly patients with COPD based on knowledge, belief, and practice model. Methods. 60 elderly patients with COPD cured in our hospital from January 2019 to April 2021 were enrolled for the study. The patients were randomly assigned to control group ( n = 30 ) and study group ( n = 30 ). The former group received routine nursing, and the latter group accepted health education based on “knowledge, belief, and practice” model. Finally, the scores of nursing satisfaction, KAP score, compliance rate, self-management level, pulmonary function, and life quality were compared in the two groups. Results. The nursing satisfaction of the study group (100.00%) was higher than that (83.33%) of the control group ( P < 0.05 ). The scores of knowledge, attitude, and behavior were remarkably higher in the study group than in the control group after nursing ( P < 0.05 ). Moreover, KAP scores also significantly increased in the study group after nursing. The compliance rate of the study group (93.33%) was higher than that of the control group (66.67%) ( P < 0.05 ). After nursing, the scores of symptom management, daily life management, emotion management, information management, and management efficiency were higher in the study group than in the control group ( P < 0.05 ). In addition, pulmonary functions were improved in the two groups following nursing. Compared with the control groups, the 6 min walking distance, FEV1%, and FEV1/FVC% were higher in the study group ( P < 0.05 ). After nursing, the scores of life quality were reduced in the two groups. The scores of physiological function, psychological function, social function, and health self-cognition were lower in the study group than in the control group ( P < 0.05 ). Conclusion. Based on the model of knowledge, belief, and practice, nurse-led health education can successfully enhance the self-management ability, satisfaction, and compliance of elderly COPD patients.

The object of this study is to examine the effects of a short-term intensive-type Cognitive Behavioral Therapy (CBT) intervention to prevent internet addiction among Chinese college students. We conducted a randomized controlled trial applying a group counseling intervention program based on CBT. Data included 21 participants in the intervention group and 22 participants in the control group. The results showed that the intervention program reduced college students’ internet addiction symptoms and procrastination and improved their sense of coherence. Regarding the sustained effect, internet addiction symptoms decreased and perceived social support from significant others improved in college students. However, the intervention program did not significantly reduce their average daily internet use time and psychological stress. Overall, this study developed a short-term intensive-type intervention program based on CBT theory, which is complementary for Chinese college students with internet addiction.

Micropapillary features are seen in pure mucinous carcinoma of breast (PMC), which is termed mucinous carcinoma with micropapillary features (MPMC). However, whether MPMC can be identified as a morphologically, clinically or genetically distinct entity from PMC remains controversial. In this study, a retrospective review of 161 cases of breast mucinous carcinoma was conducted to assess the clinicopathologic features, prognostic implications, and genomic alterations of MPMC and PMC. MPMCs were identified in 32% of mucinous carcinomas showing an excellent interobserver agreement (ICC = 0.922). MPMCs occurred at a younger age and exhibited higher nuclear grade, more frequent lymph nodal metastasis, lymphovascular invasion, and HER2 amplification compared with PMCs. Survival analyses revealed that MPMCs show decreased progression-free survival compared with PMCs in both unmatched and matched cohorts. A similar outcome of distant disease-free survival was observed only in the unmatched cohort. However, no statistical difference in recurrence score was observed between MPMC and PMC using a 21-gene assay. Notably, both MPMCs and PMCs displayed low mutation burden, common mutations affecting TTN, GATA3, SF3B1, TP53, recurrent 6q14.1-q27 losses, and 8p11.21-q24.3 gains. GATA3, TP53, and SF3B1 were recurrently mutated in MPMCs, while PIK3CA mutations were exclusively detected in PMCs. Moreover, MPMCs harbored 17q and 20q gains as well as 17p losses, while PMCs displayed gains at 6p. PI3K-Akt, mTOR, ErbB, and focal adhesion pathways were more frequently deregulated in MPMCs than in PMCs, which may responsible for the aggressive tumor behavior of MPMCs. Our findings suggest that MPMC is morphologically, clinically, and genetically distinct from PMC.

Compared to adult-onset schizophrenia, relatively few neuroimaging studies have examined functional connectivity (FC) abnormalities in adolescent-onset schizophrenia (AOS). The present study was designed to investigate resting-state interhemispheric connectivity patterns among drug-naive first-episode AOS patients and potential changes following short-term antipsychotic drug treatment.This study included 107 drug-naïve, first-episode AOS patients (age: 15.33 ± 1.62, 45 males) and 67 matched healthy controls (age: 15.43 ± 1.86, 30 males). All participants underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans, and 34 AOS patients (age: 15.12 ± 1.68, 12 males) also underwent a follow-up scan after 8 weeks of antipsychotic drug treatment. Interhemispheric functional connectivity was measured by voxel-mirrored homotopic connectivity (VMHC).Compared to healthy controls, AOS patients showed increased VMHC values in putamen and caudate. No significant differences were observed between the patients at baseline and after 8 weeks of treatment.First-episode, drug-naive AOS patients demonstrate abnormalities in interhemispheric FC, and these are not mitigated by short-term antipsychotic treatment.

Vibrio parahaemolyticus, is one of the most frequently reported pathogenic microorganisms that causes foodborne illnesses worldwide. The aims of the current study were to determine the prevalence, virulence genes, antimicrobial resistance, biofilm formation ability (BFA) and genetic characterization of V. parahaemolyticus recovered from retail aquatic products in Nanjing, China. There were 131 samples (71.6%) that tested positive for V. parahaemolyticus. The thermostable direct hemolysin-related hemolysin (trh) gene was found in two isolates (1.5%). Antimicrobial susceptibility tests showed that 46.6% of isolates were multidrug resistant. High resistance was observed to ampicillin (100%), cephalosporin (99.2%), trimethoprim/sulfamethoxazole (38.2%) and tetracycline (16.0%). Ten resistance patterns were found. The crystal violet staining assay showed that 35.1% had strong BFA, and 52.7% had intermediate BFA; notably, five (3.8%) extremely strong BFA strains were obtained from wet markets. According to whole genome sequencing analysis of 59 randomly selected isolates, 46 sequence types (STs) were identified, including 22 novel STs, and ST1042 was the dominant sequence type. It is clear that the V. parahaemolyticus population exhibits a high level of genetic variation. Our findings provide comprehensive insight into the prevalence and phylogenetic relationship of V. parahaemolyticus in aquatic products, suggesting potential hazards to consumers in Nanjing.

A novel cobweb-like disk resonator gyroscope (CDRG) with a very small frequency split between two degenerate modes has been designed and implemented. In comparison with the ring-like DRG (RDRG), the CDRG has fewer fabrication imperfections owing to its all-linear structure. In addition, the CDRG displays a superior nonlinear effect compared with the RDRG, and internal differential electrode excitation and detection were used to further reduce the nonlinear effect. The CDRGs and RDRGs were placed side by side on the same wafer, and the characteristics of these as-fabricated resonators were then tested. The results showed that the resonant frequencies and Q-factors of the CDRGs and RDRGs were approximately 18 kHz and nearly 100k, respectively. The smallest as-fabricated relative frequency split (29.9 ppm) of the CDRGs was about 10.8 times smaller than that (322.5 ppm) of an RDRG built side by side on the same wafer, which had the lowest relative frequency split among all current disk resonator gyros. Finally, the preliminary results for the performance of the CDRG and RDRG in the force-to-rebalance mode and mode matching are given. Under the same conditions, the maximum vibration displacement, scale factor, angular random walk, and bias instability of the CDRG were improved by 62.8%, 112%, 700%, and 314%, respectively, compared with the RDRG.

Frequency symmetry of a cobweb-like disk resonator gyroscope (CDRG) has been compared with a conventional ring-like disk resonant gyroscope (RDRG) in this letter to corroborate that linear beam structures have a better process tolerance than curved beam structures for micro-fabrication processes. The CDRG comprises multiple concentric cobweb-like rings and each is formed by 16 identical straight beams joined end-to-end. It exhibits as-fabricated symmetric vibration behavior superior to RDRGs. To compare as-fabricated structural symmetry, CDRG and RDRG are placed side-by-side on the same wafer and simulated using COMSOL. A tested frequency split as low as 0.56 Hz is achieved for CDRG, and the average relative frequency split is 79.7 ppm, which is approximately seven times smaller than that of RDRG. Additionally, a temperature characteristics test demonstrates that the as-fabricated CDRG has excellent temperature stability, and the relative frequency split varied by 2.83 ppm in the temperature ranging from −20 °C to +80 °C. The proposed concept is verified by the simulation and experimental results.

Nondestructive tomographic identification of underlying moldy lesions of apple is demonstrated experimentally, for the first time, by using frequency domain diffuse optical tomography (FD-DOT). The custom applicator-probe had 18 optodes distributed on a spheroid apple-size imaging domain. The 12 source channels were time-multiplexed to a laser source modulated at 110 MHz, and the 6 detector channels were individually conditioned for parallel heterodyning at 10 kHz. The iterative image reconstruction was performed without priors in an open-source finite-element-method (FEM) package with custom meshing of the imaging domain. Cylindrical moldy lesions in apple at controlled center depths ranging from 10 mm to 35 mm were established using 10 mm diameter cylinder inclusions harvested from mildew flesh, and freeform lesions in apple were developed by injecting colonies of Alternaria alternate. The moldy lesions not deeper than 20 mm from the peel were resolvable on the absorption images. The moldy lesions were unremarkable on the reduced scattering images. Contrast-detail-analysis is also performed in simulation to assess the condition of identifying a moldy-core lesion by FD-DOT.

Overexpression of reactive oxygen species in the substantia nigra pars compacta destroys dopaminergic neurons and accelerates the pathological process of Parkinson's disease (PD). In this study, a new hydrophilic nano-bioconjugate, lactoferrin (Lf)-modified Au-Bi

Multiplexing the ion packet injection with advanced signal processing is an effective method to improve both the ion throughput and signal-to-noise ratio for ion mobility spectrometry. Generally used multiplexing methods include Hadamard transform ion mobility spectrometry (HT-IMS), Fourier transform ion mobility spectrometry (FT-IMS), and correlation ion mobility spectrometry (C-IMS). However, HT-IMS sometimes suffer from false peaks and further processing is needed, FT-IMS generally requires longer spectra acquisition time than the traditional signal averaging method, and C-IMS also demonstrated drawbacks such as spectra baseline distortions when using traditional on-off binary gating switches. To improve the performance of multiplexing ion mobility spectrometry, this study investigates the Fourier deconvolution to increase the resolving power and signal-to-noise ratio at the same time. This approach modulates the ion gate with a linear square wave chirp sequence and synchronizes the data acquisition and ion gate modulation and then reconstructs the ion mobility spectra based on convolution theorems. The equivalent ion injection period is decreased to microseconds scale with the signal-to-noise ratio improved by up to 13 times on average, and the resolving power is improved by up to 50% compared with traditional signal averaging methods without hardware modifications.

Variability in spatial accessibility of emergency medical services has become a major concern in evaluating the quality of emergency medical services in China. Unlike some other public services, response time is critical in the provision of emergency medical services. Traffic congestion may significantly affect response time, especially in large cities. This study uses a transportation simulation model to estimate the travel time under free-flow and congested road conditions and measure the corresponding spatial accessibility of emergency medical services for various hours of a day in inner-city Shanghai. When traffic congestion is considered, the overall spatial accessibility is significantly reduced, and the effect is further magnified in certain congested areas. The results help policy makers in planning the emergency medical services resource that is sensitive to the spatiotemporal variation of its accessibility.

Overexpression of reactive oxygen species in the substantia nigra pars compacta destroys dopaminergic neurons and accelerates the pathological process of Parkinson's disease (PD). In this study, a new hydrophilic nano-bioconjugate, lactoferrin (Lf)-modified Au-Bi2 Se3 nanodot (ND) for efficient PD therapy is developed. In particular, the Lf-Au-Bi2 Se3 NDs exhibit strong blood-brain barrier (BBB) permeation. The Lf-Au-Bi2 Se3 NDs can also serve as multiple enzymes such as superoxide dismutase, catalase, glutathione peroxidase, and peroxide. These NDs are located close to the mitochondria and thus maintain the mitochondrial membrane potential as well as control the cellular ROS level. In vivo results further demonstrate that the NDs can improve the memory and mobility of PD mice; permeation of the BBB, protection of mitochondria, and suppression of dopaminergic neuron loss in the substantia nigra pars compacta are also observed. It is anticipated that these new Lf-Au-Bi2 Se3 NDs with excellent biocompatibility, multienzyme functionality, and BBB permeability will open new opportunities for PD therapy.