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790 results on '"Wennberg, Richard A."'

1. 18F-Flortaucipir (AV1451) imaging identifies grey matter atrophy in retired athletes

Author

Vasilevskaya, Anna, Anastassiadis, Chloe, Thapa, Simrika, Taghdiri, Foad, Khodadadi, Mozhgan, Multani, Namita, Rusjan, Pablo, Ozzoude, Miracle, Tarazi, Apameh, Mushtaque, Asma, Wennberg, Richard, Houle, Sylvain, Green, Robin, Colella, Brenda, Vasdev, Neil, Blennow, Kaj, Zetterberg, Henrik, Karikari, Thomas, Sato, Christine, Moreno, Danielle, Rogaeva, Ekaterina, Mikulis, David, Davis, Karen Deborah, Tator, Charles, and Tartaglia, Maria Carmela

Published
2024
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2. Functional connectivity changes in neurodegenerative biomarker-positive athletes with repeated concussions

Author

Garcia-Cordero, Indira, Vasilevskaya, Anna, Taghdiri, Foad, Khodadadi, Mozhgan, Mikulis, David, Tarazi, Apameh, Mushtaque, Asma, Anssari, Neda, Colella, Brenda, Green, Robin, Rogaeva, Ekaterina, Sato, Christine, Grinberg, Mark, Moreno, Danielle, Hussain, Mohammed W., Blennow, Kaj, Zetterberg, Henrik, Davis, Karen D., Wennberg, Richard, Tator, Charles, and Tartaglia, Maria C.

Published
2024
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7. Investigating the use of plasma pTau181 in retired contact sports athletes

Author

Vasilevskaya, Anna, Taghdiri, Foad, Multani, Namita, Ozzoude, Miracle, Tarazi, Apameh, Khodadadi, Mozhgan, Wennberg, Richard, Rusjan, Pablo, Houle, Sylvain, Green, Robin, Colella, Brenda, Blennow, Kaj, Zetterberg, Henrik, Karikari, Thomas, Mikulis, David, Hazrati, Lili-Naz, Kovacs, Gabor G., Davis, Karen Deborah, Tator, Charles, and Tartaglia, Maria Carmela

Published
2022
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11. Wavelet phase coherence of ictal scalp EEG-extracted muscle activity (SMA) as a biomarker for sudden unexpected death in epilepsy (SUDEP).

Author

Gravitis, Adam C., Sivendiran, Krishram, Tufa, Uilki, Zukotynski, Katherine, Chinvarun, Yotin, Devinsky, Orrin, Wennberg, Richard, Carlen, Peter L., and Bardakjian, Berj L.

Subjects
PEOPLE with epilepsy, SUDDEN death, EPILEPSY, BIOMARKERS, SEIZURES (Medicine)
Abstract

Objective: Approximately 50 million people worldwide have epilepsy and 8–17% of the deaths in patients with epilepsy are attributed to sudden unexpected death in epilepsy (SUDEP). The goal of the present work was to establish a biomarker for SUDEP so that preventive treatment can be instituted. Approach: Seizure activity in patients with SUDEP and non-SUDEP was analyzed, specifically, the scalp EEG extracted muscle activity (SMA) and the average wavelet phase coherence (WPC) during seizures was computed for two frequency ranges (1–12 Hz, 13–30 Hz) to identify differences between the two groups. Main results: Ictal SMA in SUDEP patients showed a statistically higher average WPC value when compared to non-SUDEP patients for both frequency ranges. Area under curve for a cross-validated logistic classifier was 81%. Significance: Average WPC of ictal SMA is a candidate biomarker for early detection of SUDEP. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Unifying biophysical consciousness theories with MaxCon: maximizing configurations of brain connectivity.

Author

Perez Velazquez, Jose Luis, Martin Mateos, Diego, Guevara, Ramon, and Wennberg, Richard

Subjects
NERVOUS system, SYSTEM dynamics, CONSCIOUSNESS, NEUROANATOMY, COGNITION
Abstract

There is such a vast proliferation of scientific theories of consciousness that it is worrying some scholars. There are even competitions to test different theories, and the results are inconclusive. Consciousness research, far from converging toward a unifying framework, is becoming more discordant than ever, especially with respect to theoretical elements that do not have a clear neurobiological basis. Rather than dueling theories, an integration across theories is needed to facilitate a comprehensive view on consciousness and on how normal nervous system dynamics can develop into pathological states. In dealing with what is considered an extremely complex matter, we try to adopt a perspective from which the subject appears in relative simplicity. Grounded in experimental and theoretical observations, we advance an encompassing biophysical theory, MaxCon, which incorporates aspects of several of the main existing neuroscientific consciousness theories, finding convergence points in an attempt to simplify and to understand how cellular collective activity is organized to fulfill the dynamic requirements of the diverse theories our proposal comprises. Moreover, a computable index indicating consciousness level is presented. Derived from the level of description of the interactions among cell networks, our proposal highlights the association of consciousness with maximization of the number of configurations of neural network connections --constrained by neuroanatomy, biophysics and the environment-- that is common to all consciousness theories. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Unusual combinations of neurodegenerative pathologies with chronic traumatic encephalopathy (CTE) complicates clinical prediction of CTE.

Author

Taghdiri, Foad, Khodadadi, Mozhgan, Sadia, Nusrat, Mushtaque, Asma, Scott, Olivia F. T., Hirsch‐Reinhagen, Veronica, Tator, Charles, Wennberg, Richard, Kovacs, Gabor G., and Tartaglia, M. Carmela

Subjects
CHRONIC traumatic encephalopathy, HEAD injuries, BRAIN concussion, CONTACT sports, PATHOLOGY, OLDER patients
Abstract

Background and purpose: Chronic traumatic encephalopathy (CTE) has gained widespread attention due to its association with multiple concussions and contact sports. However, CTE remains a postmortem diagnosis, and the link between clinical symptoms and CTE pathology is poorly understood. This study aimed to investigate the presence of copathologies and their impact on symptoms in former contact sports athletes. Methods: This was a retrospective case series design of 12 consecutive cases of former contact sports athletes referred for autopsy. Analyses are descriptive and include clinical history as well as the pathological findings of the autopsied brains. Results: All participants had a history of multiple concussions, and all but one had documented progressive cognitive, psychiatric, and/or motor symptoms. The results showed that 11 of the 12 participants had evidence of CTE in the brain, but also other copathologies, including different combinations of tauopathies, and other rare entities. Conclusions: The heterogeneity of symptoms after repetitive head injuries and the diverse pathological combinations accompanying CTE complicate the prediction of CTE in clinical practice. It is prudent to consider the possibility of multiple copathologies when clinically assessing patients with repetitive head injuries, especially as they age, and attributing neurological or cognitive symptoms solely to presumptive CTE in elderly patients should be discouraged. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Maternal Instruction About Jaundice and the Incidence of Acute Bilirubin Encephalopathy in Nigeria

Author

Wennberg, Richard P., Oguche, Stephen, Imam, Zainab, Farouk, Zubaida L., Abdulkadir, Isa, Sampson, Paul D., Slusher, Tina M., Bode-Thomas, Fidelia, Toma, Bose O., Yilgwan, Christopher S., Shwe, David, Ofakunrin, Akinyemi O., Diala, Udochukwu M., Isichei, Chris, Pam, Victor, Hassan, Zuwaira, Abdullahi, Shehu U., Usman, Fatima, Jibir, Binta W., Mohammed, Idris Y., Usman, Hadiza A., Abdusalam, Muhammed, Kuliya-Gwarzo, Aisha, Tsiga-Ahmad, Fatima I., Umar, Laila, Ogala, William N., Abdullahi, Fatimatu, Hassan, Laila, Purdue, Saratu, Lund, Troy, and Coda-Zabetta, Carlos D.

Published
2020
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21. Neurocognitive and Seizure Outcomes of Selective Amygdalohippocampectomy versus Anterior Temporal Lobectomy for Mesial Temporal Lobe Epilepsy

Author

Mansouri, Alireza, Fallah, Aria, McAndrews, Mary Pat, Cohn, Melanie, Mayor, Diana, Andrade, Danielle, Carlen, Peter, del Campo, Jose M, Tai, Peter, Wennberg, Richard A, and Valiante, Taufik A

Subjects
Clinical and Health Psychology, Psychology, Epilepsy, Neurodegenerative, Clinical Research, Mental Health, Neurosciences, Brain Disorders, 2.1 Biological and endogenous factors, Aetiology, Neurological
Abstract

Objective. To report our institutional seizure and neuropsychological outcomes for a series of patients with mesial temporal lobe epilepsy (mTLE) undergoing anterior temporal lobectomy (ATL) or selective amygdalohippocampectomy (SelAH) between 2004 and 2011. Methods. A retrospective study of patients with mTLE was conducted. Seizure outcome was reported using time-to-event analysis. Cognitive outcome was reported using the change principal in component factor scores, one each, for intellectual abilities, visuospatial memory, and verbal memory. The Boston Naming Test was used for naming assessment. Language dominant and nondominant resections were compared separately. Student's t-test was used to assess statistical significance. Results. Ninety-six patients (75 ATL, 21 SelAH) were included; fifty-four had complete neuropsychological follow-up. Median follow-up was 40.5 months. There was no statistically significant difference in seizure freedom or any of the neuropsychological outcomes, although there was a trend toward greater postoperative decline in naming in the dominant hemisphere group following ATL. Conclusion. Seizure and neuropsychological outcomes did not differ for the two surgical approaches which is similar to most prior studies. Given the theoretical possibility of SelAH sparing language function in patients with epilepsy secondary to mesial temporal sclerosis and the limited high-quality evidence creating equipoise, a multicenter randomized clinical trial is warranted.

Published
2014

23. Misfolded α‐Synuclein in Cerebrospinal Fluid of Contact Sport Athletes

Author

Vasilevskaya, Anna, primary, Martinez‐Valbuena, Ivan, additional, Anastassiadis, Chloe, additional, Taghdiri, Foad, additional, Khodadadi, Mozhgan, additional, Tarazi, Apameh, additional, Green, Robin, additional, Colella, Brenda, additional, Wennberg, Richard, additional, Mikulis, David, additional, Davis, Karen Deborah, additional, Kovacs, Gabor G., additional, Tator, Charles, additional, and Tartaglia, Maria Carmela, additional

Published
2023
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26. Standardized computer-based organized reporting of EEG: SCORE – Second version

Author

Beniczky, Sándor, Aurlien, Harald, Brøgger, Jan C., Hirsch, Lawrence J., Schomer, Donald L., Trinka, Eugen, Pressler, Ronit M., Wennberg, Richard, Visser, Gerhard H., Eisermann, Monika, Diehl, Beate, Lesser, Ronald P., Kaplan, Peter W., Nguyen The Tich, Sylvie, Lee, Jong Woo, Martins-da-Silva, Antonio, Stefan, Hermann, Neufeld, Miri, Rubboli, Guido, Fabricius, Martin, Gardella, Elena, Terney, Daniella, Meritam, Pirgit, Eichele, Tom, Asano, Eishi, Cox, Fieke, van Emde Boas, Walter, Mameniskiene, Ruta, Marusic, Petr, Zárubová, Jana, Schmitt, Friedhelm C., Rosén, Ingmar, Fuglsang-Frederiksen, Anders, Ikeda, Akio, MacDonald, David B., Terada, Kiyohito, Ugawa, Yoshikazu, Zhou, Dong, and Herman, Susan T.

Published
2017
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27. Investigation of neurophysiologic and functional connectivity changes following glioma resection using magnetoencephalography

Author

Samuel, Nardin, primary, Harmsen, Irene E, additional, Ding, Mandy Yi Rong, additional, Sarica, Can, additional, Vetkas, Artur, additional, Wong, Christine, additional, Lawton, Vanessa, additional, Yang, Andrew, additional, Rowland, Nathan C, additional, Kalia, Suneil K, additional, Valiante, Taufik, additional, Wennberg, Richard, additional, Zadeh, Gelareh, additional, Kongkham, Paul, additional, Kalyvas, Aristotelis, additional, and Lozano, Andres M, additional

Published
2023
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28. Automated Interpretation of Clinical Electroencephalograms Using Artificial Intelligence

Author

Tveit, Jesper, primary, Aurlien, Harald, additional, Plis, Sergey, additional, Calhoun, Vince D., additional, Tatum, William O., additional, Schomer, Donald L., additional, Arntsen, Vibeke, additional, Cox, Fieke, additional, Fahoum, Firas, additional, Gallentine, William B., additional, Gardella, Elena, additional, Hahn, Cecil D., additional, Husain, Aatif M., additional, Kessler, Sudha, additional, Kural, Mustafa Aykut, additional, Nascimento, Fábio A., additional, Tankisi, Hatice, additional, Ulvin, Line B., additional, Wennberg, Richard, additional, and Beniczky, Sándor, additional

Published
2023
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33. Ictal ECG-based assessment of sudden unexpected death in epilepsy

Author

Gravitis, Adam C., primary, Tufa, Uilki, additional, Zukotynski, Katherine, additional, Streiner, David L., additional, Friedman, Daniel, additional, Laze, Juliana, additional, Chinvarun, Yotin, additional, Devinsky, Orrin, additional, Wennberg, Richard, additional, Carlen, Peter L., additional, and Bardakjian, Berj L., additional

Published
2023
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37. Pain in Bone Metastases: Types and Mechanisms

Author

Wallace, Elaine, Slaven, Marissa, Wennberg, Richard, Zimmermann, Camilla, Ablin, Richard J., Series editor, Jiang, Wen G., Series editor, Vassiliou, Vassilios, editor, Chow, Edward, editor, and Kardamakis, Dimitrios, editor

Published
2014
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43. Multi-modal investigation of transcranial ultrasound-induced neuroplasticity of the human motor cortex

Author

Samuel, Nardin, primary, Zeng, Ke, additional, Harmsen, Irene E., additional, Ding, Mandy Yi Rong, additional, Darmani, Ghazaleh, additional, Sarica, Can, additional, Santyr, Brendan, additional, Vetkas, Artur, additional, Pancholi, Aditya, additional, Fomenko, Anton, additional, Milano, Vanessa, additional, Yamamoto, Kazuaki, additional, Saha, Utpal, additional, Wennberg, Richard, additional, Rowland, Nathan C., additional, Chen, Robert, additional, and Lozano, Andres M., additional

Published
2022
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49. A Peri-Ictal EEG-Based Biomarker for Sudden Unexpected Death in Epilepsy (SUDEP) Derived From Brain Network Analysis

Author

Tufa, Uilki, Gravitis, Adam, Zukotynski, Katherine, Chinvarun, Yotin, Devinsky, Orrin, Wennberg, Richard, Carlen, Peter L., and Bardakjian, Berj L.

Abstract

Sudden unexpected death in epilepsy (SUDEP) is the leading seizure-related cause of death in epilepsy patients. There are no validated biomarkers of SUDEP risk. Here, we explored peri-ictal differences in topological brain network properties from scalp EEG recordings of SUDEP victims. Functional connectivity networks were constructed and examined as directed graphs derived from undirected delta and high frequency oscillation (HFO) EEG coherence networks in eight SUDEP and 14 non-SUDEP epileptic patients. These networks were proxies for information flow at different spatiotemporal scales, where low frequency oscillations coordinate large-scale activity driving local HFOs. The clustering coefficient and global efficiency of the network were higher in the SUDEP group pre-ictally, ictally and post-ictally (p < 0.0001 to p < 0.001), with features characteristic of small-world networks. These results suggest that cross-frequency functional connectivity network topology may be a non-invasive biomarker of SUDEP risk.

Published
2022

50. Imaging in medically refractory epilepsy at 3 Tesla: a 13-year tertiary adult epilepsy center experience

Author

Hainc, Nicolin; https://orcid.org/0000-0003-0916-7387, McAndrews, Mary Pat, Valiante, Taufik, Andrade, Danielle M, Wennberg, Richard, Krings, Timo, Hainc, Nicolin; https://orcid.org/0000-0003-0916-7387, McAndrews, Mary Pat, Valiante, Taufik, Andrade, Danielle M, Wennberg, Richard, and Krings, Timo

Abstract

Objectives: MRI negative epilepsy has evolved through increased usage of 3 T and insights from surgically correlated studies. The goal of this study is to describe dedicated 3 T epilepsy MRI findings in medically refractory epilepsy (MRE) patients at a tertiary epilepsy center to familiarize radiologists with an updated spectrum and frequency of potential imaging findings in the adult MRE population. Methods: Included were all patients with MRE admitted to the epilepsy monitoring unit who were discussed at weekly interdisciplinary imaging conferences at Toronto Western Hospital with MRI studies (3 T with dedicated epilepsy protocol) performed between January 2008 and January 2021. Lesion characterization was performed by two readers based on most likely imaging diagnosis in consensus. Lobes involved per case were recorded. Results: A total of 738 patients (386 female; mean age 35 years, range 15–77) were included. A total of 262 patients (35.5%) were MRI negative. The most common imaging finding was mesial temporal sclerosis, seen in 132 patients (17.9%), followed by encephalomalacia and gliosis, either posttraumatic, postoperative, postischemic, or postinfectious in nature, in 79 patients (10.7%). The most common lobar involvement (either partially or uniquely) was temporal (341 cases, 58.6%). MRE patients not candidates for surgical resection were included in the study, as were newly described pathologies from surgically correlated studies revealing findings seen retrospectively on reported MRI negative exams (isolated enlargement of the amygdala, temporal pole white matter abnormality, temporal encephalocele). Conclusion: This study provides an updated description of the spectrum of 3 T MRI findings in adult MRE patients from a tertiary epilepsy center.

Published
2022

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