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163 results on '"Weng, Wen-Hui"'

8. Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2

Author

Ler, Lian Dee, Ghosh, Sujoy, Chai, Xiaoran, Thike, Aye Aye, Heng, Hong Lee, Siew, Ee Yan, Dey, Sucharita, Koh, Liang Kai, Lim, Jing Quan, Lim, Weng Khong, Myint, Swe Swe, Loh, Jia Liang, Ong, Pauline, Sam, Xin Xiu, Huang, Dachuan, Lim, Tony, Tan, Puay Hoon, Nagarajan, Sanjanaa, Cheng, Christopher Wai Sam, Ho, Henry, Ng, Lay Guat, Yuen, John, Lin, Po-Hung, Chuang, Cheng-Keng, Chang, Ying-Hsu, Weng, Wen-Hui, Rozen, Steven G., Tan, Patrick, Creasy, Caretha L., Pang, See-Tong, McCabe, Michael T., Poon, Song Ling, and Teh, Bin Tean

Published
2017
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17. Gain of TPPP as a predictor of progression in patients with bladder cancer

Author

Chang, Ying-Hsu, primary, Lin, Po-Hung, additional, Chen, Chin-Chang, additional, Weng, Wen-Hui, additional, Yu, Kai-Jie, additional, Liu, Chung-Yi, additional, Hsieh, Chin-Hsuan, additional, Chang, Tzu-Hsuan, additional, Shao, I-Hung, additional, Kan, Hung-Cheng, additional, Chuang, Cheng-Keng, additional, and Pang, See-Tong, additional

Published
2021
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24. Expression of ezrin is associated with invasion and dedifferentiation of hepatitis B related hepatocellular carcinoma

Author

Weng Wen-Hui, Wu Ren-Ching, Chen Tsung-Wen, Pang See-Tong, Yeh Chun-Nan, and Chen Miin-Fu

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Hepatocellular carcinoma (HCC) is the fifth most common malignancy in the world and constitutes the leading cause of cancer-related death among men, and second among women in Taiwan. Liver cirrhosis and HCC are relatively prevalent, and 80% to 85% of the patients with these conditions have positive results for hepatitis B surface antigen in Taiwan. Only 5% of the general population is seronegative for all hepatititis B virus (HBV) markers. This is the first study to determine the role of ezrin upon HBV HCC cell and patients with HBV HCC undergoing hepatectomy Methods Immunohistochemical study with ezrin in 104 human HBV-HCC cases were carried out to investigate its association with the clinicopathological features and the outcomes of 104 HBV-HCC patients undergoing hepatetomy. In addition, DNA constructs including the wild type ezrin (wt-ezrin) and mutant ezrin Tyr353 (Y353) were transfected into Hep3B cell to study its role in tumor invasion and differentiation. Results HBV HCC patients with ezrin over-expression independently have smaller tumor size, cirrhotic liver background, poor tumor differentiation, and more vascular invasion. Ezrin expression status has no impact on survival for HBV-HCC patients undergoing hepatectomy. The in vitro assay showed that wt-ezrin Hep3B cells have a significant higher level of AFP secretion and higher invasion ability as compared with the control and Y353- ezrin Hep3B cells. Conclusion Ezrin over-expression contributed to de-differentiation and invasion of HBV-HCC cell. HBV-HCC patients with ezrin over-expression were independently associated with tumor with smaller size, cirrhotic liver background, poor differentiation, and vascular invasion.

Published
2009
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26. Cabozantinib-induced osteoblast secretome promotes survival and migration of metastatic prostate cancer cells in bone

Author

Yu, Kai-Jie, primary, Li, Jeffrey K., additional, Lee, Yu-Chen, additional, Yu, Guoyu, additional, Lin, Song-Chang, additional, Pan, Tianhong, additional, Satcher, Robert L., additional, Titus, Mark A., additional, Yu-Lee, Li-Yuan, additional, Weng, Wen Hui, additional, Gallick, Gary E., additional, and Lin, Sue-Hwa, additional

Published
2017
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38. Mutation signatures implicate aristolochic acid in bladder cancer development

Author

Poon, Song Ling, primary, Huang, Mi Ni, additional, Choo, Yang, additional, McPherson, John R, additional, Yu, Willie, additional, Heng, Hong Lee, additional, Gan, Anna, additional, Myint, Swe Swe, additional, Siew, Ee Yan, additional, Ler, Lian Dee, additional, Ng, Lay Guat, additional, Weng, Wen-Hui, additional, Chuang, Cheng-Keng, additional, Yuen, John SP, additional, Pang, See-Tong, additional, Tan, Patrick, additional, Teh, Bin Tean, additional, and Rozen, Steven G, additional

Published
2015
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41. Abstract 4907: The Emerging technology of Yb2Ti2O7 electrolyte-insulator-semiconductor biosensors for rapid screening of targeted mutation

Author

Kao Shin Hsun, Pang Sow Neng, Jhou Cheng Han, Weng Wen Hui, and Pan Tung Ming

Subjects
Genetics, Cancer Research, Chemistry, Wild type, Electrolyte, Buffer solution, Insulator (genetics), medicine.disease_cause, Molecular biology, chemistry.chemical_compound, Oncology, Targeted Mutation, Cancer cell, medicine, KRAS, Biosensor
Abstract

Genetic mutations play an important role in the development of most cancers; thus, they have become key targets of investigation in the discovery of new biomarkers to help with cancer diagnostic and prognostic prediction, as well as monitor the development of drug resistance in cancer cells. We have now developed a technique by designing several probes that contain with different types of mutations, including substitution, insertion and deletion mutations for 6 or 12 bps (Table 1). Following this, we then mapped a colorectal cancer wild type KRAS cell line Caco2. To screen for different types of gene alterations,an electrolyte-insulator-semiconductor (EIS) device, incorporating a high-κ Yb2Ti2O7 sensing membrane deposited on Si substrates through co-sputtering to screen the genetic mutations, was made. X-ray diffraction and X-ray photoelectron spectroscopy were used to explore the structural features of these films annealed at various temperatures. The Yb2Ti2O7 EIS device, which annealed at 900 °C, exhibited a higher sensitivity of 59.4 mV/pH (in the solutions from pH = 2 to pH = 12), a lower hysteresis voltage of 1.6 mV (in the pH = 7→4→7→10→7), and a smaller drift rate of 0.16 mV/h (in the pH = 7 buffer solution) than those of the other annealing temperatures. We successfully demonstrated that high-κYb2Ti2O7 EIS devices with DNA-immobilized alginate films were able to screen all the designed mutation probes in Caco2 cells, and there was clear distinction from wild type based lines. In addition, even the substitution mutations were presented high resolution. Current measurement system provides a simple and inexpensive method for rapid and accurate detection of genetic changes in target genes; therefore it provided the high potential to serve as a diagnosis tool in clinical practice in the future. Table 1.Design oligonucleotide probes.Oligonucleotide probessequencesTest 1wild type 24 bp5′-taggcaagagtgccttgacgatac-3′deletion 12 bp5′-taggca…………cgatac-3′deletion 6 bp5′-taggcaaga……tgacgatac-3′Test 2wild type 24 bp5′-ataggtgattttggtctagctaca-3′substitution 1 bp5′-ataggtgatttAggtctagctaca-3′insertion 6 bp5′-ataggtgattttGGGAACggtctagctaca-3′ Citation Format: Jhou Cheng Han, Kao Shin Hsun, Pang Sow Neng, Pan Tung Ming, Weng Wen Hui. The Emerging technology of Yb2Ti2O7 electrolyte-insulator-semiconductor biosensors for rapid screening of targeted mutation. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4907. doi:10.1158/1538-7445.AM2015-4907

Published
2015

45. Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool

Author

Poon, Song Ling, primary, Pang, See-Tong, additional, McPherson, John R., additional, Yu, Willie, additional, Huang, Kie Kyon, additional, Guan, Peiyong, additional, Weng, Wen-Hui, additional, Siew, Ee Yan, additional, Liu, Yujing, additional, Heng, Hong Lee, additional, Chong, Soo Ching, additional, Gan, Anna, additional, Tay, Su Ting, additional, Lim, Weng Khong, additional, Cutcutache, Ioana, additional, Huang, Dachuan, additional, Ler, Lian Dee, additional, Nairismägi, Maarja-Liisa, additional, Lee, Ming Hui, additional, Chang, Ying-Hsu, additional, Yu, Kai-Jie, additional, Chan-on, Waraporn, additional, Li, Bin-Kui, additional, Yuan, Yun-Fei, additional, Qian, Chao-Nan, additional, Ng, Kwai-Fong, additional, Wu, Ching-Fang, additional, Hsu, Cheng-Lung, additional, Bunte, Ralph M., additional, Stratton, Michael R., additional, Futreal, P. Andrew, additional, Sung, Wing-Kin, additional, Chuang, Cheng-Keng, additional, Ong, Choon Kiat, additional, Rozen, Steven G., additional, Tan, Patrick, additional, and Teh, Bin Tean, additional

Published
2013
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