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805 results on '"Wendt, Daniel"'

1. Scalable DAQ system operating the CHIPS-5 neutrino detector

Author

Rancurel, Belén Alonso, Cao, Son, Carroll, Thomas J., Castellan, Rhys, Catano-Mur, Erika, Cesar, John P., Coelho, João A. B., Dills, Patrick, Dodwell, Thomas, Edmondson, Jack, van Eijk, Daan, Fetterly, Quinn, Garbal, Zoé, Germani, Stefano, Gilpin, Thomas, Giraudo, Anthony, Habig, Alec, Hanuska, Daniel, Hausner, Harry, Hernandez, Wilson Y., Holin, Anna, Huang, Junting, Jones, Sebastian B., Karle, Albrecht, Kileff, George, Jenkins, Kai R., Kooijman, Paul, Kreymer, Arthur, LaFond, Gabe M., Lang, Karol, Lazar, Jeffrey P., Li, Rui, Liu, Kexin, Loving, David A., Mánek, Petr, Marshak, Marvin L., Meier, Jerry R., Miller, William, Nelson, Jeffrey K., Ng, Christopher, Nichol, Ryan J., Paolone, Vittorio, Perch, Andrew, Pfützner, Maciej M., Radovic, Alexander, Rawlins, Katherine, Roedl, Patrick, Rogers, Lucas, Safa, Ibrahim, Sousa, Alexandre, Tingey, Josh, Thomas, Jennifer, Trokan-Tenorio, Jozef, Vahle, Patricia, Wade, Richard, Wendt, Christopher, Wendt, Daniel, Whitehead, Leigh H., Wolcott, Samuel, and Yuan, Tianlu

Subjects
Physics - Instrumentation and Detectors
Abstract

The CHIPS R&D project focuses on development of low-cost water Cherenkov neutrino detectors through novel design strategies and resourceful engineering. This work presents an end-to-end DAQ solution intended for a recent 5 kt CHIPS prototype, which is largely based on affordable mass-produced components. Much like the detector itself, the presented instrumentation is composed of modular arrays that can be scaled up and easily serviced. A single such array can carry up to 30 photomultiplier tubes (PMTs) accompanied by electronics that generate high voltage in-situ and deliver time resolution of up to 0.69 ns. In addition, the technology is compatible with the White Rabbit timing system, which can synchronize its elements to within 100 ps. While deployment issues did not permit the presented DAQ system to operate beyond initial evaluation, the presented hardware and software successfully passed numerous commissioning tests that demonstrated their viability for use in a large-scale neutrino detector, instrumented with thousands of PMTs., Comment: 30 pages, 28 figures, submitted to MDPI Applied Sciences, Special Issue: Advanced Neutrino Detector Development and Application

Published
2024

2. Intraoperative haemoadsorption for antithrombotic drug removal during cardiac surgery: initial report of the international safe and timely antithrombotic removal (STAR) registry

Author

Schmoeckel, Michael, Thielmann, Matthias, Hassan, Kambiz, Geidel, Stephan, Schmitto, Jan, Meyer, Anna L., Vitanova, Keti, Liebold, Andreas, Marczin, Nandor, Bernardi, Martin H., Tandler, Rene, Lindstedt, Sandra, Matejic-Spasic, Marijana, Wendt, Daniel, Deliargyris, Efthymios N., and Storey, Robert F.

Published
2024
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3. Techno-Economic Analysis of Synthetic Fuel Production from Existing Nuclear Power Plants across the United States

Author

Garrouste, Marisol, Craig, Michael T., Wendt, Daniel, Diaz, Maria Herrera, Jenson, William, Zhang, Qian, and Kochunas, Brendan

Subjects
Economics - General Economics
Abstract

Low carbon synfuel can displace transport fossil fuels such as diesel and jet fuel and help achieve the decarbonization of the transportation sector at a global scale, but large-scale cost-effective production facilities are needed. Meanwhile, nuclear power plants are closing due to economic difficulties: electricity prices are too low and variable to cover their operational costs. Using existing nuclear power plants to produce synfuels might prevent loss of these low-carbon assets while producing synfuels at scale, but no technoeconomic analysis of this Integrated Energy System exist. We quantify the technoeconomic potential of coupling a synthetic fuel production process with five example nuclear power plants across the U.S. to explore the influence of different electricity markets, access to carbon dioxide sources, and fuel markets. Coupling synfuel production increases nuclear plant profitability by up to 792 million USD(2020) in addition to a 10 percent rate of return on investment over a 20 year period. Our analysis identifies drivers for the economic profitability of the synfuel IES. The hydrogen production tax credit from the 2022 Inflation Reduction Act is essential to its overall profitability representing on average three quarters of its revenues. The carbon feedstock transportation is the highest cost - more than a third on average - closely followed by the synfuel production process capital costs. Those results show the key role of incentive policies for the decarbonization of the transportation sector and the economic importance of the geographic location of Integrated Energy Systems., Comment: 34 pages, 15 figures

Published
2023

7. Stratified estimation of forest inventory variables using spatially summarized stratifications

Author

McRoberts, Ronald, Wendt, Daniel, and Liknes, Greg

Subjects
Forestry, SD1-669.5
Abstract

Large area natural resource inventory programs typically report estimates for selected geographic areas such as states or provinces, counties, and municipalities. To increase the precision of estimates, inventory programs may use stratified estimation, with classified satellite imagery having been found to be an efficient and effective basis for stratification. For the benefit of users who desire additional analyses, the inventory programs often make data and estimation procedures available via the Internet. For their own analyses, users frequently request access to stratifications used by the inventory programs. When data analysis is via the Internet and stratifications are based on classifications of even medium resolution satellite imagery, the memory requirements for storing the stratifications and the online time for processing them may be excessive. One solution is to summarize the stratifications at coarser spatial scales, thus reducing both storage requirements and processing time. If the bias and loss of precision resulting from using summaries of stratifications is acceptably small, then this approach is viable. Methods were investigated for using summaries of stratifications that do not require storing and processing the entire pixel-level stratifications. Methods that summarized satellite image-based 30 m x 30 m pixel stratifications at spatial scales up to 2400 ha produced stratified estimates of the mean that were generally within 5-percent of estimates for the same areas obtained using the pixel stratifications. In addition, stratified estimates of variances using summarized stratifications realized nearly all the gain in precision that was obtained with the underlying pixel stratifications.

Published
2005
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10. Identifying therapeutic drug targets using bidirectional effect genes.

Author

Estrada, Karol, Froelich, Steven, Wuster, Arthur, Bauer, Christopher, Sterling, Teague, Clark, Wyatt, Ru, Yuanbin, Trinidad, Marena, Nguyen, Hong, Luu, Amanda, Wendt, Daniel, Yogalingam, Gouri, Yu, Guoying, LeBowitz, Jonathan, and Cardon, Lon

Subjects
Drug Discovery, Dwarfism, Genes, Genetic Association Studies, Humans, Natriuretic Peptide, C-Type, Pharmaceutical Preparations, Phenotype, Receptor, Fibroblast Growth Factor, Type 3, Receptor, IGF Type 1, Receptors, Atrial Natriuretic Factor, Short Stature Homeobox Protein
Abstract

Prioritizing genes for translation to therapeutics for common diseases has been challenging. Here, we propose an approach to identify drug targets with high probability of success by focusing on genes with both gain of function (GoF) and loss of function (LoF) mutations associated with opposing effects on phenotype (Bidirectional Effect Selected Targets, BEST). We find 98 BEST genes for a variety of indications. Drugs targeting those genes are 3.8-fold more likely to be approved than non-BEST genes. We focus on five genes (IGF1R, NPPC, NPR2, FGFR3, and SHOX) with evidence for bidirectional effects on stature. Rare protein-altering variants in those genes result in significantly increased risk for idiopathic short stature (ISS) (OR = 2.75, p = 3.99 × 10-8). Finally, using functional experiments, we demonstrate that adding an exogenous CNP analog (encoded by NPPC) rescues the phenotype, thus validating its potential as a therapeutic treatment for ISS. Our results show the value of looking for bidirectional effects to identify and validate drug targets.

Published
2021

14. Midterm outcomes with a sutureless aortic bioprosthesis in a prospective multicenter cohort study

Author

Zannis, Kostantinos, Pfeiffer, Steffen, Santarpino, Giuseppe, Shrestha, Malakh, Sarikouch, Samir, Gummert, Jan F., Mohr, Friedrich W., Dohmen, Pascal, Stalder, Mario, Roost, Eva, Filipiak, Krzysztof, Niklewski, Tomasz, Madonna, Francesco, Roques, Xavier, Flameng, Willem J., Laczkovics, Axel M.M., Bechtel, Matthias, Prat, Alain G., Banfi, Carlo, Dapunt, Otto E., Eichstaedt, Harald C., Harringer, Wolfgang, Carstens-Fitz, Ulrike, Spyt, Tom J., Wimmer-Greinecker, Jan Gerhard, Machner, Matthias, Tan, Erwin S.H., Casselman, Filip P.A., Yilmaz, Alaaddin, Sonker, Uday, Bleiziffer, Sabine, Oberwalder, Peter J., Kocher, Alfred A., Seitelberger, Rainald, Treede, Hendrik, Conradi, Leonard, Cocchieri, Riccardo, De Mol, Bas, Roussel, Jean-Christian, Despins, Philippe, Jakob, Heinz G., Wendt, Daniel, Fischlein, Theodor, Meuris, Bart, Folliguet, Thierry, Hakim-Meibodi, Kavous, Misfeld, Martin, Carrel, Thierry, Zembala, Marian, Cerutti, Elisa, Asch, Federico M., and Haverich, Axel

Published
2022
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15. External stenting and disease progression in saphenous vein grafts two years after coronary artery bypass grafting: A multicenter randomized trial

Author

Benedetto, Umberto, Vohra, Hunaid, Bittar, Mohamad Nidal, Bose, Amal, Berman, Marius, Kharbanda, Rajesh, Paraforos, Alexandros, Ladyshenskij, Leonid, Bonaros, Nikolaos, Schachner, Thomas, Sandner, Sigrid, Angleitner, Philipp, Bolotin, Gil, Jacobs, Stephan, Thielmann, Matthias, Wendt, Daniel, Choi, Yeong-Hoon, Liakopoulos, Oliver, Ohri, Sunil, Lipey, Alexander, Taggart, David P., Gavrilov, Yulia, Krasopoulos, George, Rajakaruna, Cha, Zacharias, Joseph, De Silva, Ravi, Channon, Keith M., Gehrig, Thomas, Donovan, Terrence John, and Friedrich, Ivar

Published
2022
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17. Hohes Alter

Author

Wendt, Daniel, Gerstner, Jan, editor, Heller, Jakob C., editor, and Schmitt, Christian, editor

Published
2022
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26. Hybrid coronary revascularization: position paper of the European Society of Cardiology Working Group on Cardiovascular Surgery and European Association of Percutaneous Cardiovascular Interventions.

Author

Thielmann, Matthias, Bonaros, Nikolaos, Barbato, Emanuele, Barili, Fabio, Folliguet, Thierry, Friedrich, Guy, Gottardi, Roman, Legutko, Jacek, Parolari, Alessandro, Punjabi, Prakash, Sandner, Sigrid, Suwalski, Piotr, Shehada, Sharaf-Eldin, Wendt, Daniel, Czerny, Martin, and Muneretto, Claudio

Subjects
CORONARY artery bypass, INTERNAL thoracic artery, MYOCARDIAL revascularization, PERCUTANEOUS coronary intervention, DRUG-eluting stents, CARDIOVASCULAR surgery
Abstract

Myocardial revascularization in coronary artery disease via percutaneous coronary intervention or coronary artery bypass graft (CABG) surgery effectively relieves symptoms, significantly improves prognosis and quality of life when combined with guideline-directed medical therapy. Hybrid coronary revascularization is a promising alternative to percutaneous coronary intervention or CABG in selected patients and is defined as a planned and/or intended combination of consecutive CABG surgery using at least 1 internal mammary artery to the left anterior descending (LAD), and catheter-based coronary intervention to the non-LAD vessels for the treatment of multivessel disease. The main indications for hybrid coronary revascularization are (i) to achieve complete revascularization in patients who cannot undergo conventional CABG, (ii) to treat patients with acute coronary syndromes and multivessel disease with a non-LAD vessel as the culprit lesion that needs revascularization and (iii) in highly select patients with multivessel disease with complex LAD lesions and simple percutaneous coronary intervention targets for all other vessels. Hybrid coronary revascularization patients receive a left internal mammary artery graft to the LAD artery through a minimal incision along with percutaneous coronary intervention to the remaining diseased coronary vessels using latest generation drug-eluting stents. A collaborative environment with a dedicated heart team is the optimal platform to perform such interventions, which aim to improve the quality and outcome of myocardial revascularization. This position paper analyses the rationale of hybrid coronary revascularization and the currently available evidence on the various techniques and delves into the sequence of the interventions and pharmacological management during and after the procedure. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Impact of Bioprosthetic Choice on Mortality After Transfemoral Transcatheter Aortic Valve Implantation in Patients With Reduced Versus Preserved Left-Ventricular Ejection Fraction

Author

El-Chilali, Karim, Al-Rashid, Fadi, Riebisch, Matthias, Kahlert, Heike Annelie, Mincu, Raluca-Ileana, Totzeck, Matthias, Lind, Alexander, Jánosi, Rolf Alexander, Dirkmann, Daniel, Peters, Jürgen, Wendt, Daniel, Thielmann, Matthias, Jakob, Heinz, Ruhparwar, Arjang, Rassaf, Tienush, and Kahlert, Philipp

Published
2020
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31. The role of hemoadsorption in cardiac surgery – a systematic review

Author

Matejic-Spasic, Marijana, primary, Lindstedt, Sandra, additional, Lebreton, Guillaume, additional, Dzemali, Omer, additional, Suwalski, Piotr, additional, Folliguet, Thierry, additional, Geidel, Stephan, additional, Klautz, Robert J.M., additional, Baufreton, Christophe, additional, Livi, Ugolino, additional, Gunaydin, Serdar, additional, Deliargyris, Efthymios N., additional, Wendt, Daniel, additional, and Thielmann, Matthias, additional

Published
2024
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34. Standardized in vitro bleeding tests in a non-coated novel hybrid prosthesis for frozen elephant trunk demonstrates minimal oozing during full heparinization, supported by clinical data

Author

Jakob, Heinz, primary, Leins, Timo, additional, Avci-Adali, Meltem, additional, Schlensak, Christian, additional, Wendt, Daniel, additional, Mehta, Yatin, additional, Thielmann, Matthias, additional, Görlinger, Klaus, additional, Song, Suk-Won, additional, and Tsagakis, Konstantinos, additional

Published
2023
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37. Impact of pre-existing comorbidities on outcomes of patients undergoing surgical aortic valve replacement – rationale and design of the international IMPACT registry

Author

Bakhtiary, Farhad, Ahmad, Ali El-Sayed, Autschbach, Rüdiger, Benedikt, Peter, Bonaros, Nikolaos, Borger, Michael, Dewald, Oliver, Feyrer, Richard, Geißler, Hans-Joachim, Grünenfelder, Jürg, Lam, Ka Yan, Leyh, Rainer, Liebold, Andreas, Czesla, Markus, Mehdiani, Arash, Pollari, Francesco, Salamate, Saad, Strauch, Justus, Vötsch, Andreas, Weber, Alberto, Wendt, Daniel, Botta, Beate, Bramlage, Peter, and Zierer, Andreas

Published
2021
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39. Cytokine Hemoadsorption During Cardiac Surgery Versus Standard Surgical Care for Infective Endocarditis (REMOVE): Results From a Multicenter Randomized Controlled Trial

Author

Diab, Mahmoud, Lehmann, Thomas, Bothe, Wolfgang, Akhyari, Payam, Platzer, Stephanie, Wendt, Daniel, Deppe, Antje-Christin, Strauch, Justus, Hagel, Stefan, Günther, Albrecht, Faerber, Gloria, Sponholz, Christoph, Franz, Marcus, Scherag, André, Velichkov, Ilia, Silaschi, Miriam, Fassl, Jens, Hofmann, Britt, Lehmann, Sven, Schramm, Rene, Fritz, Georg, Szabo, Gabor, Wahlers, Thorsten, Matschke, Klaus, Lichtenberg, Artur, Pletz, Mathias W., Gummert, Jan F., Beyersdorf, Friedhelm, Hagl, Christian, Borger, Michael A., Bauer, Michael, Brunkhorst, Frank M., and Doenst, Torsten

Published
2022
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43. Delivery of an enzyme-IGFII fusion protein to the mouse brain is therapeutic for mucopolysaccharidosis type IIIB

Author

Kan, Shih-Hsin, Aoyagi-Scharber, Mika, Le, Steven Q, Vincelette, Jon, Ohmi, Kazuhiro, Bullens, Sherry, Wendt, Daniel J, Christianson, Terri M, Tiger, Pascale MN, Brown, Jillian R, Lawrence, Roger, Yip, Bryan K, Holtzinger, John, Bagri, Anil, Crippen-Harmon, Danielle, Vondrak, Kristen N, Chen, Zhi, Hague, Chuck M, Woloszynek, Josh C, Cheung, Diana S, Webster, Katherine A, Adintori, Evan G, Lo, Melanie J, Wong, Wesley, Fitzpatrick, Paul A, LeBowitz, Jonathan H, Crawford, Brett E, Bunting, Stuart, Dickson, Patricia I, and Neufeld, Elizabeth F

Subjects
Biochemistry and Cell Biology, Biological Sciences, Alzheimer's Disease, Acquired Cognitive Impairment, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Mucopolysaccharidoses (MPS), Biotechnology, Aging, Orphan Drug, Rare Diseases, Neurosciences, Neurodegenerative, Dementia, Brain Disorders, Neurological, Metabolic and endocrine, Acetylglucosaminidase, Animals, Biomarkers, Brain, CHO Cells, Cells, Cultured, Cricetinae, Cricetulus, Drug Delivery Systems, Endocytosis, Fibroblasts, Heparitin Sulfate, Humans, Injections, Intraventricular, Insulin-Like Growth Factor II, Liver, Lysosome-Associated Membrane Glycoproteins, Mice, Mucopolysaccharidosis III, Neurons, Protein Binding, Recombinant Fusion Proteins, beta-N-Acetylhexosaminidases
Abstract

Mucopolysaccharidosis type IIIB (MPS IIIB, Sanfilippo syndrome type B) is a lysosomal storage disease characterized by profound intellectual disability, dementia, and a lifespan of about two decades. The cause is mutation in the gene encoding α-N-acetylglucosaminidase (NAGLU), deficiency of NAGLU, and accumulation of heparan sulfate. Impediments to enzyme replacement therapy are the absence of mannose 6-phosphate on recombinant human NAGLU and the blood-brain barrier. To overcome the first impediment, a fusion protein of recombinant NAGLU and a fragment of insulin-like growth factor II (IGFII) was prepared for endocytosis by the mannose 6-phosphate/IGFII receptor. To bypass the blood-brain barrier, the fusion protein ("enzyme") in artificial cerebrospinal fluid ("vehicle") was administered intracerebroventricularly to the brain of adult MPS IIIB mice, four times over 2 wk. The brains were analyzed 1-28 d later and compared with brains of MPS IIIB mice that received vehicle alone or control (heterozygous) mice that received vehicle. There was marked uptake of the administered enzyme in many parts of the brain, where it persisted with a half-life of approximately 10 d. Heparan sulfate, and especially disease-specific heparan sulfate, was reduced to control level. A number of secondary accumulations in neurons [β-hexosaminidase, LAMP1(lysosome-associated membrane protein 1), SCMAS (subunit c of mitochondrial ATP synthase), glypican 5, β-amyloid, P-tau] were reduced almost to control level. CD68, a microglial protein, was reduced halfway. A large amount of enzyme also appeared in liver cells, where it reduced heparan sulfate and β-hexosaminidase accumulation to control levels. These results suggest the feasibility of enzyme replacement therapy for MPS IIIB.

Published
2014

45. Techno-Economic Analysis of Product Diversification Options for Sustainability of the Monticello and Prairie Island Nuclear Power Plants

Author

Knighton, Lane, primary, Wendt, Daniel, additional, Richards, James, additional, Rabiti, Cristian, additional, Abou Jaoude, Abdalla, additional, Westover, Tyler, additional, Vedros, Kurt, additional, Bates, Samuel, additional, Elgowainy, Amgad, additional, Bafana, Adarsh, additional, Boardman, Richard, additional, Reddi, Krishna, additional, Zang, Guiyan, additional, Ruth, Mark, additional, Frew, Bethany, additional, Levie, Daniel, additional, Jadun, Paige, additional, Desai, Jal, additional, Bernhoft, Sherry, additional, Westlakd, Brittany, additional, McCollum, David, additional, Ludwig, Daniel, additional, Strasser, Molly, additional, and Ramler, Bryan, additional

Published
2021
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49. Reoperative Surgery

Author

Droc, Ionel, Droc, Gabriela, Buzilă, Cosmin Alexandru, Wendt, Daniel, Ursulescu, Adrian, Ţintoiu, Ion C., editor, Underwood, Malcolm John, editor, Cook, Stephane Pierre, editor, Kitabata, Hironori, editor, and Abbas, Aamer, editor

Published
2016
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