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BACKGROUND: Uniportal video-assisted thoracoscopic surgery (VATS) segmentectomy is widely used in the field of thoracic surgery. However, anatomical variations in the bronchi and lung vessels may be critical obstacles during precise pulmonary segmentectomy. Thus, it is necessary to optimize uniportal VATS segmentectomy and to accurately identify the plane between lung segments by precisely transecting the bronchi and blood vessels of the lung segments. The indocyanine green fluorescence (ICGF)-based method has the potential to be a feasible and effective technique to facilitate the uniportal VATS segmentectomy. The present study aims at comparing the short-term outcomes of ICGF versus the traditional inflation-deflation method for uniportal VATS segmentectomy. METHODS: The perioperative clinical data in 200 consecutive patients undergoing uniportal VATS segmentectomy from December 2018 to August 2020 at Shanghai Chest Hospital were analyzed retrospectively. The targeted segment structures were identified and dissected precisely by using ICGF-based (N=100) or the traditional inflation-deflation (N=100) methods. The parameters of intraoperative blood loss and operation time, postoperative drainage volume, air leakage time, drainage tube retention time, length of hospital stay, and complications in the ICGF group were collected. Further, the operation time between the ICGF and the inflation-deflation groups was compared. The data summary and statistical analysis were performed by SPSS 19.0. P value

Selective semi-hydrogenation of phenylacetylene to styrene is a crucial step in the polystyrene industry. Although Pd-based catalysts are widely used in this reaction due to their excellent hydrogenation activity, the selectivity for styrene remains a great challenge. Herein, we designed a mesoporous silica stabilized Pd-Ru@ZIF-8 (MS Pd-Ru@ZIF-8) nanoreactor with novel Pd and Ru single site synergistic catalytical system for semi-hydrogenation of phenylacetylene. The nanoreactor exhibited a superior performance, achieving 98% conversion of phenylacetylene and 96% selectivity to styrene. Turnover frequency (TOF) of nanoreactor was up to as high as 2,188 h⁻¹, which was 25 times and 5 times more than the single metal species catalysts, mesoporous silica stabilized Pd@ZIF-8 nanoreactor (MS Pd@ZIF-8), and mesoporous silica stabilized Ru@ZIF-8 nanoreactor (MS Ru@ZIF-8). This catalytic activity was attributed to the synergistic effect of Pd and Ru single site anchored strongly into the framework of ZIF-8, which reduced the desorption energy of styrene and increased the hydrogenation energy barrier of styrene. Importantly, since the ordered mesoporous silica was introduced into the nanoreactor shell to stabilize ZIF-8, MS Pd-Ru@ZIF-8 showed excellent reusability and stability. After the five cycles, the catalytical activity and selectivity still remained. This work provides insights for a synergistic catalytic system based on single-site active sites for selective hydrogenation reactions.

The accurate and efficient calculation of the rate coefficients of chemical reactions is a key issue in the research of chemical dynamics. In this work, by applying the dimension-free ultrastable Cayley propagator, the thermal rate coefficients of a prototypic high dimensional chemical reaction OH + CH

Molecular ferroelectrics have captured immense attention due to their superiority over inorganic oxide ferroelectrics, such as environmentally friendly, low-cost, flexible, foldable. However, the mechanisms of ferroelectric switching and phase transition for the molecular ferroelectrics are still missing, leaving the development of novel molecular ferroelectrics less efficient. In this work, we have provided a methodology combining molecular dynamics (MD) simulation on a polarized force field named polarized crystal charge (PCC) and enhanced sampling technique, replica-exchange molecular dynamics (REMD) to simulate such mechanisms. With this procedure, we have investigated a promising molecular ferroelectric material, (R)/(S)-3-quinuclidinol crystal. We have simulated the ferroelectric hysteresis loops of both enantiomers and obtained spontaneous polarization of 7/8 \mu C cm-2 and a corresponding coercive electric field of 15 kV cm-1. We also find the Curie temperature as 380/385 K for ferro-/para-electric phase transition of both enantiomers. All of the simulated results are highly compatible with experimental values. Besides of that, we predict a novel Curie temperature of about 600 K. This finding is further validated by principal component analysis (PCA). Our work would significantly promote the future exploration of multifunctional molecular ferroelectrics for the next generation of intelligent devices.

Automation and intelligent health monitoring technologies will be one of the most important development directions for rail transit operation and maintenance considering the continuous expansion of...

OBJECTIVE: To compare the effectiveness of locking plate and intramedullary nail in treatment of Neer two- and three-part fractures of the proximal humerus in the elderly. METHODS: A retrospective analysis was conducted on 86 elderly patients with Neer two- and three-part fractures of the proximal humerus met the selection criteria between January 2015 and December 2018. Forty-six patients were treated with locking plate fixation (locking plate group), and 40 patients with intramedullary nail fixation (intramedullary nail group). There was no significant difference in gender, age, cause of injury, fracture side and type, time from injury to operation, and comorbidities between the two groups (P>0.05). Visual analogue scale (VAS) score, American Shoulder and Elbow Surgery (ASES) score, Constant-Murley score, and shoulder range of motion (forward flexion, abduction, and external rotation) were compared between the two groups. X-ray films were taken to assess the fracture healing, and the neck-shaft angle was measured at 2 days after operation and at last follow-up, and the difference between the two time points was calculated. RESULTS: Patients in both groups were followed up 18-40 months, with an average of 30.4 months. There was no significant difference in follow-up time between the two groups (t=−0.986,P=0.327). X-ray films reexamination showed that the fractures of two groups healed, and the healing time was (11.3±2.1) weeks in locking plate group and (10.3±2.0) weeks in intramedullary nail group, which had significant difference between the two groups (t=2.250, P=0.027). The difference of neck-shaft angle was (7.63±7.01)° in locking plate group and (2.85±2.82)° in intramedullary nail group, which had significant difference between the two groups (t=4.032, P0.05). Complications occurred in 13 cases (28.3%) of locking plate group and in 4 cases (10.0%) of intramedullary nail group, and the difference between the two groups was significant (χ(2)=4.498, P=0.034). CONCLUSION: Both locking plates and intramedullary nails can be used for the treatment of Neer two- and three-part fractures of the proximal humerus in the elderly. The intramedullary nail fixation surgery is more minimally invasive, which has fewer postoperative complications and faster fracture healing.

Review question / Objective: Is acupuncture a safe and effective therapy for constipation associated with Parkinson’s disease? Our aim is to assess the effectiveness and safety of acupuncture for constipation associated with PD and give guidance to future research direction. Condition being studied: Parkinson’s disease (PD) is a prevalent degenerative disease of nervous system characterized mainly by static tremor, bradykinesia, myotonia, postural gait disorders and other non-motor symptoms. According to variations on race, ethnicity, age and sex, the incidence of PD ranges from 8 to 20.5 per 100, 000 individuals annually. One global research shows that there were 6.1 million individuals suffer from PD in 2016 and will be 12 million patients around the world. According to several outcomes of case-control studies, the prevalence of constipation in PD varies from 28% to 61%. Constipation, as a common gastrointestinal disease which refers to the clinical presentation of reduced spontaneous complete bowel movement, dyschezia, feeling of incomplete defecation and outlet obstruction, is demonstrated to antedate the motor symptom and it's severity is related to the progression of PD. Acupuncture has been proved to act on the pathogenesis of constipation associated with PD. The proposed systematic review we're about to present is the first advanced evidence-based medical evidence in this area.

The accurate and efficient calculation of the rate coefficients of chemical reactions is a key issue in the research of chemical dynamics. In this work, by applying the dimension-free ultra-stable Cayley propagator, the thermal rate coefficients of a prototypic high dimensional chemical reaction OH + CH4 -> H2O + CH3 in the temperature range of 200 K to 1500 K are investigated with ring polymer molecular dynamics (RPMD), on a highly accurate full-dimensional potential energy surface. Kinetic isotope effects (KIEs) for three isotopologues of the title reaction are also studied. The results demonstrate excellent agreement with experimental data, even in the deep tunneling region. Especially, the Cayley propagator shows high calculation efficiency with little loss of accuracy. The present results confirmed the applicability of the RPMD method, particularly the speed-up by Cayley propagator, in theoretical calculations of bimolecular reaction rates., 35 pages, 7 figures (include one TOC)

This study was to design and synthesize a novel bifunctional chelator, named Dar, primarily validated by conjugating to tumor targeting motifs, labeled with radiometals, and performed preclinical evaluation of tumor imaging and cancer therapy in murine tumor models.The designed Dar was synthesized and characterized by X-ray crystallography,The Dar, as a novel bifunctional chelator for medicating the labeling of radiometals onto tumor targeting carriers, was successfully synthesized and chemically characterized. Test radiolabeling, on PSMA-617 and a nanobody as tool targeting molecule carriers, demonstrated the Dar has potential as a universal bifunctional chelator for radiolabeling various radiometals (at least

With the advent of the next generation display technology, high-speed and high-precision mass transfer has become a core technology to solve high-density Micro-LED transfer packaging. Aiming at the problem of feedforward parameter tuning of XY platform composite controller in Micro-LED mass transfer equipment, the intelligent tuning methods of feedforward parameters were researched, and an intelligent tuning algorithm of feedforward parameters based on fuzzy thought was proposed. The system response of XY motion platform with different speed feedforward and acceleration feedforward parameters was explored through experiments, and the influence law of the two feedforward controllers on the system response indexes was determined. Then, based on the thought of fuzzy control and the dynamic characteristics of the system, the fuzzy intelligent tuning algorithm for feedforward parameters was designed theoretically. Finally, based on the traditional three-loop PID control, the optimal speed feedforward parameters and acceleration feedforward parameters were set by fuzzy tuning algorithm. The feedforward parameters were applied to the X-axis servo control of XY motion platform to verify the effectiveness of the algorithm. The experimental results show that the optimal speed feedforward parameter 24.27 and acceleration feedforward parameter 52.68 can be automatically set in 34s under given conditions. The feedforward parameters obtained by the adjustment act on the X-axis of XY motion platform, which makes the system's adjustment time decrease from 30ms to less than 5ms. All these results show that the proposed algorithm can significantly improve the speed of controller parameter tuning, and the optimization efficiency is much higher than the manual trial and error method.

A reliable copper-mediated nucleophilic radiosynthesis of the PET imaging probe [

Using a Cu 2+ -dependent DNA ligation DNAzyme, a portable and sensitive biosensor for Cu 2+ detection based on personal glucose meters (PGMs) has been developed. In the presence of Cu 2+ , the DNAzyme catalyzed the ligation of nucleophilic attack of the phosphorus center of DNA1 by the hydroxyl group on DNA2 and forming a phosphodiseter bond. By introducing DNA-invertase conjugates and capture-DNA modified magnetic beads (MBs), the ligation product can hybridize with them and form invertase-functionalized MBs, which can be separated easily. The presence of invertase can convert sucrose to glucose and can be read out by the PGMs. With this method, a detection limit of 1 nM could be achieved. Moreover, the method exhibited excellent metal ion selectivity and there was almost no effect of biological complex to the detection performance, which suggested our method can be successfully applied to in biological process researches, drug discovery, and clinic diagnostics.

The β-barrel structure of green fluorescent protein (GFP) provides a confined environment to enhance its fluorescence efficiency. Inspired by the unique structure of GFP, we reported a self-restricted GFP chromophore analogue which was rationally grafted onto the middle or the terminal of poly(ethylene glycol)-block-poly(N-isopropyl acrylamide) (PEG-b-PNIPAM) via click chemistry to obtain PEG-GA-PNIPAM and PEG-PNIPAM-GA (GA: MeOBDPI). These structures were characterized through NMR, GPC, and FT-IR. By varying the length of PNIPAM and the location of the GFP chromophore, self-assembly behaviour and fluorescence intensity were correspondingly changed. PEG-GA-PNIPAM and PEG-PNIPAM-GA were assembled into nano-sized spherical micelles above the low critical solution temperature (LCST). The size of the micelles increased with the length of the PNIPAM block. These optical properties were carefully evaluated by UV-Vis and fluorescence spectroscopy. The results indicated that increasing the length of the PNIPAM block enhanced the fluorescence in water, and PEG-PNIPAM74-GA has more remarkable fluorescence intensity than PEG-GA-PNIPAM106 in living cells such as MCF-7 cells. Furthermore, the fluorescence behaviour of PEG-PNIPAM74-GA was studied in MCF-7 cells and L929 cells. The result showed that PEG-PNIPAM74-GA was mostly located in the cytoplasm. Compared with the CellTracker™ Red CMTPX dye, it could enter into MCF-7 cells and L929 cells more easily in DMEM with 10% FBS. Therefore, PEG-PNIPAM74-GA has potential application prospects for living cell imaging.

Polypyrrole (PPy)-modified CuO nanocomposites (NCs) with various shell structures have been synthesized by controlling the polymerization time of pyrrole in the presence of leaf-like CuO nanobelts (NBs) as wire templates. The synthesized CuO/PPy NCs and CuO NBs are characterized by XRD, FT–IR, TGA, SEM, TEM, STEM, and EDX line analysis/elemental mapping. The formation mechanism of CuO/PPy core–shell NCs is also illustrated. Electrochemical lithium-storage properties of all the products are evaluated by using them as anode materials for Li-ion batteries (LIBs). It is found that the polymerization time of pyrrole plays a significant role in affecting the shell structures and subsequent lithium-storage properties of the hybrid CuO/PPy NCs. With the extension of polymerization time, CuO/PPy NCs gradually form typical core–shell structures, where the doped PPy with increasing content is steadily and uniformly coated on the CuO surface. Correspondingly, the discharge/charge capacity and cyclic durability of CuO...

Structural and electrical remodeling within the atrium mediate the pathogenesis of atrial fibrillation (AF). Two key genes that sever a role in this remodeling are connexin 40 (Cx40) and potassium voltage-gated channel subfamily A member 5 (KCNA5), respectively. Electrical remodeling is considered to induce structural remodeling during AF. In the present study, the left atrial appendage section and atrial myocytes of patients with AF were evaluated. It was observed that Cx40 and KCNA5 mRNA (P

CMP is becoming an enabling technology to meet the demands of precise machining of wafer surface in various applications. In this paper, dishing and uniformity performance of an 28nm STI-CMP process was studied with the influence of machine, slurry, polish pad, polish time, zone pressure and retaining ring force are analyzed, which affects the surface geometric parameter of silicon wafer. The results of experiment indicate that STI dishing, uniformity and wafer loading of silicon wafer are improved, by using new slurry with low SiN removal rate, controlling zone pressure, adjusting retaining ring force.

We report on the synthesis and characterization of a series of donor–acceptor copolymers (PF1, PF2, PF3 or PF4) based on a dinaphtho-s-indacene (DNI) donor unit and four different acceptor units. The molecular weights of the copolymers were determined by using gel permeation chromatography, and their electrochemical properties were investigated by cyclic voltammetry. All four copolymers showed deep-lying highest occupied molecular orbital energy levels. Inverted bulk heterojunction solar cells were fabricated by using the synthesized copolymers as the electron donor material and 6,6-phenyl-C71-butyric acid methyl ester (PC71BM) as the electron acceptor material. Inverted solar cells based on PF1:PC71BM (1:4, w/w) exhibited a power conversion efficiency (PCE) of 3.07%, a high open-circuit voltage (Voc) of 0.99 V, a short-circuit current density (Jsc) of 7.85 mA/cm2, and a fill factor of 39.5% under the AM1.5G illumination. With the same fabrication method, the inverted devices based on PF2, PF3 and PF4 showed PCEs of 2.62, 1.18 and 1.32%, and Voc values of 0.97, 0.91 and 0.80 V, respectively.

PurposeChina has long been dedicated to introducing the Western management ideas to the local enterprise practice. But the situation has changed since the financial crisis, and the China model has become a hot word with its fast recovery from crisis. Moreover, Chinese traditional culture has become increasingly popular. Yin and yang are the most familiar Chinese philosophical terms to Western minds, and also the core concept of Chinese Taoist philosophy. The purpose of this paper is to analyze how the yin yang or lao‐tzu influences a firm's core competence and performance, and to demonstrate that the Taoist‐oriented Chinese culture remains meaningful and in many situations powerful in enterprise practice.Design/methodology/approachA case study is carried out from Town Star Ltd, established in 2001, and located in Linfen city, Shanxi province, China, a city which topped the list of the world's most polluted cities. It is an integrated joint‐stock company, specializing in coal coking chemical industry, gardening, logistics and technology development. Based on the humanized management doctrine, the company has formed the 5S management model which boosts its rapid and sustainable development. It coped well in major junctures such as industry restructuring and transferring, financial crisis, etc. Five key dimensions of the yin and yang, which were applied to the leader's daily behaviors and management style, are: Wu‐wei (inaction), Wu (emptiness), hardness with softness, moderation and He‐xie (harmony). First, this paper built a dynamic company growth model based on this philosophy which enhanced the core competitiveness effectively by emotional management innovation and personalized HRM, among which its pivotal regulator of variables is just yin yang conversion degree. Then an approach is provided to validate the model with empirical data collected from the years 2001‐2010 (2001‐2005, 2006‐2008, 2009‐2010) of Town Star Ltd.FindingsIt is demonstrated that yin yang ideology embedded in the company growth model organically is an important means to increase marginal benefit. In practice, the firm with yin yang philosophical ideology would shape a management paradigm which combined rules and human nature appropriately to a family‐oriented business atmosphere. Based on the above philosophical wisdom, Town Star Ltd has harvested good economic and social benefits, strong core competence through the elaborately constructed unique management model and harmonious humanity environment.Originality/valueThis paper opens an avenue for indigenous firms, as a framework for guiding management research and practice in coping with the post‐crisis era. In addition, it is expected to attract more attention from scholars, entrepreneurs both in China and in the rest of the world, to contribute to knowledge creation in Chinese management studies.

Chemical Mechanical Polishing (CMP) is considered the only processing technique that can achieve high level of local and global planarity of wafer surface and therefore widely used on IC manufacture industry [1]. However, It becomes more difficult but important to monitor CMP process performance well. In this paper, Metapulse (provided by Rudolph) and Aleris8350 (provided by Kla-Tencor) were used to monitor Cu-CMP process. The theory and characteristic of these two measurement tools were studied by using two typical monitor structures (OCD pad and Bond pad) to monitor Cu-CMP process. Performance evaluation is based on mean, range, and uniformity. Our results show that Aleris8350 is suitable for dielectric measurement to reflect topography performance of the whole wafer and Metapulse has advantage in thickness measurement for both OCD pad and Bond pad.

Combined with atomic force microscope (AFM), micro-Raman spectroscope, cross-section transmission electron microscope (TEM) and high resolution electron microscope (HREM) analyses, the surface morphology and structures of a-Si:H/a-SiN x :H multilayers (MLs), irradiated by excimer laser through the phase shifting mask grating, are investigated. It is found that Si nanocrystallites (nc-Si) are formed within the initial a-Si:H sublayers, and the size of the grains can be controlled due to the constrained crystallization effect. And it is possible to use this laser interference crystallization (LIC) method to get the periodic distribution of nc-Si in both transverse and longitudinal direction.

Tetracyclines have been widely used in bone histomorphometry to label new bone formation and apposition rate. However, most studies of tetracyclines have also shown their strong inhibitory action on osteoclasts and their effects on osteoblast activities as well. To even obtain the in-depth understanding on this issue, we have reviewed related studies in "Pubmed" by searching the keywords "tetracyclines and osteoclast", "tetracyclines and osteoblast", which retrieved 118 and 162 related documents, respectively. Among these papers, some described the application of tetracyclines as fluorescent marker in bone histomorphometry, while others discussed their role in protection of bone metabolism partly through inhibiting osteoclastogenesis or bone resorption and through enhancing osteogenesis. Based on the above mentioned, it seems that tetracyclines used as bone labeling markers may affect the results of bone histomorphometry to some extent. To even confirm the effect of tetracyclines on bones cells (osteoblast, osteoclast) and in vivo bone remodeling, related research work has been performed in our research team which indicated quite different results in vivo and in vitro. Therefore, the influence of tetracyclines on bones may differ in terms of different conditions which need to be further elucidated.

OBJECTIVE To assess the efficacy and safety of compound matrine injection combined with cisplatin chemotherapy for advanced gastric cancer. METHOD It was searched relevant randomized Controlled trials (RCTs) from Cochrane Library, PubMed, EMBASE, CBM, and CNKI etc. The search was finished in February 11, 2010. And it was traced the related references and experts in this field, besides it was also communicated with other authors in order to obtain some certain information that had not been found. RCTs of compound matrine injection combined with cisplatin chemotherapy versus cisplatin chemotherapy for advanced gastric cancer were included. It was evaluated the quality of these included studies and analyzed data by Cochrane Collaboration's RevMan 5.0 software. RESULT Ten RCTs were included meta analysis results suggested that compared with chemotherapy alone, the combination had a statistically significant benefit in healing efficacy (OR = 1.99, 95% CI: 1.26-3.13, P < 0.05) and improving quality of life (OR = 3.83, 95% CI: 2.38-6.15, P < 0.001). Besides, the combination also had a statistically significant benefit in myelosuppression, white blood cell (OR = 0.44, 95% CI: 0.32-0.62, P < 0.001), hematoblast (OR = 0.40, 95% CI: 0.26-0.60, P < 0.001), liver function (OR = 0.33, 95% CI: 0.15-0.75, P < 0.05) and in reducing the gastroenteric reaction (OR = 0.32, 95% CI: 0.16-0.63, P = 0.001), decreasing the of CD3 ( MD = 2.96, 95% CI: 1.724. 20, P < 0.001), CD4 (MD = 9.04, 95% CI: 7.87-10.20, P < 0.001), CD4/CD8 (MD = 0.47, 95% CI: 0.41-0.54, P < 0.001) and NK cells (MD = 5.90, 95% CI: 4.53-7.26, P < 0.001). CONCLUSION Compared with cisplatin chemotherapy, compound matrine injection combined with cisplatin chemotherapy can significantly improve the efficiency, QOL and myelosuppression, and reduce adverse events.