1. Indole alkaloids from Ophiorrhiza cantoniensis with immunosuppressive activity
- Author
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Wen-Zhe Xie, Tao Feng, Hui-Xiang Yang, Zheng-Hui Li, and Ji-Kai Liu
- Subjects
China ,Circular dichroism ,Stereochemistry ,T-Lymphocytes ,T cell ,Phytochemicals ,Rubiaceae ,01 natural sciences ,B-cell proliferation ,Indole Alkaloids ,Drug Discovery ,medicine ,Animals ,IC50 ,Cells, Cultured ,Cell Proliferation ,Pharmacology ,Indole test ,B-Lymphocytes ,Mice, Inbred BALB C ,Molecular Structure ,biology ,010405 organic chemistry ,Chemistry ,General Medicine ,biology.organism_classification ,Ophiorrhiza ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,medicine.anatomical_structure ,Female ,Immunosuppressive Agents ,Spleen - Abstract
Three new indole alkaloids, ophiorrhines C–D (1–3), together with one known analogue, have been isolated from the plant of Ophiorrhiza cantoniensis Hace. The structures of the new alkaloids with the absolute configurations were elucidated by means of spectroscopic methods, electronic circular dichroism (ECD) and calculated nuclear magnetic resonance (NMR) with DP4+ analysis. Compounds 1 and 2 exhibited certain activity to Con-A induced T cell proliferation, and 1 exhibited good inhibition on LPS-induced B cell proliferation with an IC50 value of 8.7 μM.
- Published
- 2021
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