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A new microporous Zn(ii)-based MOF 1 has been successfully synthesized by utilizing both amino- and nitro-functionalized ligands. Gas sorption explorations reveal that the activated sample exhibits significant C2H2 uptakes and selective capture from CO2.

A copper-catalyzed radical difluoroalkylation of arylacetylenes with bromodifluoroamides has been developed. The reaction exhibits good functional group tolerance and allows access to a variety of substituted α-alkynyl-α,α-difluoroacetamides in moderate to good yields. The potential for scale-up reaction and products derivatization also makes this method attractive for practical applications. Preliminary mechanistic studies suggest that a radical reaction pathway might be involved in the catalytic system.

Primary lymphoma involving the breast accounts for only 0.04–0.5% of malignant breast tumors, constituting 1–2 % of all non-Hodgkin lymphomas (NHL). Here, we report a case of breast ALK-positive ALCL arising in a 21-year-old woman in pregnancy with single abscess as the first clinical manifestation.

The SARS-CoV-2 pandemic has become a severe global public health event, and the development of protective and therapeutic strategies is urgently needed. Downregulation of angiotensin converting enzyme 2 (ACE2; one of the important SARS-CoV-2 entry receptors) and aberrant inflammatory responses (cytokine storm) are the main targets to inhibit and control COVID-19 invasion. Silver nanomaterials have well-known pharmaceutical properties, including antiviral, antibacterial, and anticancer properties. Here, based on a self-established metal evaporation-condensation-size graded collection system, smaller silver particles reaching the Ångstrom scale (AgÅPs) were fabricated and coated with fructose to obtain a stabilized AgÅP solution (F-AgÅPs). F-AgÅPs potently inactivated SARS-CoV-2 and prevented viral infection. Considering the application of anti-SARS-CoV-2, a sterilized F-AgÅP solution was produced

Using a rigid 3,5-di(2′,5′-dicarboxylphenyl)benzoic acid, two porous 3D MOFs have been synthesized and characterized, and the luminescent properties have been studied.

Two novel Ni/Co-MOFs electrocatalysts were synthesized. Ni-MOF demonstrated a good activity in electrocatalytic OER performances and short-term electrochemical durability.

Acute respiratory distress syndrome (ARDS) is a life-threatening condition characterized by increased permeability of the alveolar-capillary barrier and impaired alveolar fluid clearance. Resolvin E1 (RvE1) is a specialized pro-resolving mediator derived endogenously from omega-3-polyunsaturated fatty acids. RvE1 (10 μg/kg i.v.) was injected to rats 6 h post-lipopolysaccharide (LPS) (14 mg/kg) induction. After another 3 h, alveolar fluid clearance was measured in live rats (n = 8-9). The primary Type II alveolar epithelial cell was isolated and treated by LPS (1 μg/mL) with or without RvE1 (250 nM). The expression of epithelial sodium channel (ENaC), Na+/K+-ATPase (NKA), AKT, serum- and glucocorticoid-induced kinase 1 (SGK1), and Nedd4-2 were detected. RvE1 improved survival rate (30% vs. 70%, P = 0.048), increased the clearance of alveolar fluid (13.34% vs. 18.73%, P 0.001), reduced lung wet-dry weight ratio (5.01 vs. 4.63, P 0.001), mitigated lung injury scores (13.38 vs. 7.0, P 0.05) and inflammation in LPS-induced ARDS in rats. RvE1 upregulated alveolar ENaC and NKA expression in vivo and in vitro. In addition, RvE1 significantly increased the expression of phosphorylated AKT, SGK1, and phosphorylated Nedd4-2 in LPS-stimulated primary alveolar type II cells. The effects of RvE1 were abrogated by blocking phosphatidylinositide3'-kinase (PI3K) and SGK1 with LY294002 and GSK650394, respectively. In summary, RvE1 upregulated ENaC and NKA expression by activating PI3K/AKT/SGK1 pathway to promote alveolar fluid clearance, suggesting that RvE1 may be a potentially effective drug for ARDS treatment.

Postoperative pain has adverse effects on children with urological problems, including sleep disturbances, incision dehiscence, bleeding and delayed recovery. Accurate parental assessment of children's behaviours and responses could help to manage postoperative pain. We aimed to implement evidence-based practice for parental involvement in a urology ward, to increase parents' participation in children's postoperative pain management.The project was conducted in a paediatric urology ward using the framework and methods of the Fudan University Evidence-Based Nursing Center's Evidence-based Continuous Quality Improvement Model.Fifteen audit criteria were used to represent best practice recommendations for parental involvement in postoperative pain management. A pre-implementation audit was conducted with 211 randomly sampled children and parents. Obstacles, promoting factors and key strategies were analysed, and evidence-based interventions implemented to improve compliance. A follow-up audit using the same audit criteria was conducted with 202 children and parents to assess the effect of targeted strategies on compliance with best practice. The SQUIRE guidelines were followed.At the baseline audit, compliance with the evidence-based criteria was 0%-71.5%; only five audit criteria achieved a compliance rate 60%. After best practice implementation, the follow-up audit showed compliance improvements for all criteria; compliance for three criteria improved to 100%.This best practice implementation project improved parents' participation in children's postoperative pain management. The findings demonstrate how audits can promote best practice in postoperative pain management for children. Additional studies will be conducted to address children's postoperative life quality based on best practice.

Polycyclic aromatic hydrocarbons (PAHs) are widely present in the environment as toxic pollutants. In this study, quantum chemistry methods are used to study reactions of PAHs in both particle and gas phases. Seven theoretical methods are exploited to predict the reactive sites of 15 PAHs in the particle phase. Among these methods, the performance of the condensed Fukui function (CFF) is optimum. The gas-phase reactions of eight PAHs are also investigated. Except for fluorene, CFF predicts correctly the gas-phase mono-nitro products for seven systems. The products of fluorene predicted by CFF are 1-nitrofluorene and 3-nitrofluorene, which is however inconsistent with the experimental results. Transition state theory is then used to investigate the reaction mechanism of fluorene. Calculated rate constants for 3-nitrofluorene and 2-nitrofluorene formation are much bigger than that for 1-nitrofluorene formation, which is in agreement with the experimental results.

On the basis of an undeveloped asymmetrical pyridylcarboxylate ligand, 2-(2-carboxypyridin-4-yl)terephthalic acid (H3CPTA), an indium pyridylcarboxylate framework, [(Me)2NH2]1.5[In1.5(CPTA)2]·5.5NMF·6H2O (1), is synthesized under solvent thermal conditions. 1 displays a 3D anionic framework with a large void space, which contains open square channels with a cross section of 14.6 A and a pore surface decorated with carboxylic oxygen atoms. Depending on the anionic skeleton and high water stability, 1 exhibits high adsorption selectivity and capacity for cationic dyes in aqueous solution. Furthermore, the luminescence performance illustrates that 1 has selectivity and sensitivity to nitenpyram with good recyclability.

A bifunctional ligand strategy for modification of the functional pores is of great significance in the structural design of metal-organic frameworks (MOFs). Herein, a new 2-fold interpenetrated "pillared-layer" 3D Co-MOF, {[Co(HL)(4,4'-bipy)]·DMF·2H2O}n (1), was successfully synthesized by using two kinds of ligands, imidazolecarboxylic acid and pyridine. The metal-carboxylic layers are pillared by the 4,4'-bipy ligand, displaying a 3D framework with rectangular 3D channels (high BET surface of 190.9 m2 g-1 and maximum aperture of 3.9 A) that are decorated with abundant uncoordinated N and O atoms. 1 shows good water stability and thermal stability (320 °C). The proper pores and active sites endowed 1 with a selective adsorption of Congo red in aqueous solution. In addition, a high CO2 adsorption capacity and an excellent CO2 chemical conversion were observed.

A new 3D luminescent Ba-organic framework {[Ba3L2(NMP)2(H2O)2]·2NMP·H2O}n (1) was first synthesized based on Ba(II) and a triangular-shaped bridging rigid ligand, namely 1,3,5-tris(4-carboxyphenly)benzene (H3L), via solvothermal reaction (NMP = N-methyl pyrrolidone), thereby forming a stabilized network including a one-dimensional (1D) infinite rod-like helical metal chain. 1 may be explored as a recyclable heterogeneous catalyst for the efficient fixation of CO2 to form serviceable cyclic carbonate since 1D channels remain decorated with abundant open metal sites (OMSs), and the catalytic efficiency of 1 was up to 98% for 1-bromo-2,3-propylene oxide. Simultaneously, the luminescence sensing shows that 1 has excellent response and sensitivity towards pollutants such as Fe3+, Cr2O72−, CrO42−, and [Fe(CN)6]3− ions. Moreover, 1 exhibits the particularly selective sorption towards the Congo red (CR) dye. Consequently, this study may provide a facile synthetic route for the construction of multi-functional Ba-MOF materials.

Two new three-dimensional (3D) metal–organic frameworks (MOFs), namely {[Cu2(L)(4,4′-bipy)(OH)]·H2O}n (1) and {[Mn3(L)2(4,4′-bipy)(DMA)2]·H2O}n (2), were constructed by a newly synthesized thioether carboxylic acid ligand 5-((formic acid-3-sulfur)methyl)isophthalic acid (H3L) and 4,4′-bipyridine (4,4′-bipy). Thioether bonds in H3L can rotate freely in space, which are conducive in constructing MOFs with rich and stable structures. Simultaneously, the uncoordinated sulfur atoms affect the polarity of the framework and play an important role in adsorption. Gas adsorption results indicated that 1 can selectively adsorb CO2 from the mixture of CH4/CO2. Moreover, due to the high catalytic activity of [Cu4(COO)6N4O2] clusters, 1 is also an excellent recyclable catalyst that can chemically fix CO2 into cyclic carbonate under mild solvent-free conditions. Therefore, 1 may be explored as a dual-functional material for industrial adsorption and catalysis.

A new multi-functional metal–organic framework, {[Cu2(HL)(H2O)2]·NMP·2H2O}n (1), was assembled by employing an asymmetrical V-shaped rigid multicarboxylic acid ligand H5L (H5L = 2,4-di(2′,5′-dicarboxylphenyl)benzoic acid) with Cu(II) ions. 1 possesses a 3D pore formed by two types of intersecting 1D cuboid channels. Moreover, owing to the abundant uncoordinated carboxylate O atoms decorated in the channels and open metal centers generated by the removal of coordinated water molecules, 1 exhibits a high CO2 adsorption capacity and significantly selective capture for CO2 over CH4. Hence, further research on the chemical fixation of CO2 is implemented, which reveals excellent heterogeneous catalytic activity. In addition, 1 displays particularly selective sorption towards the rhodamine B (RB) dye. Consequently, this study may provide a facile synthetic route for the construction of multi-functional materials.

As a functional bowel disorder, irritable bowel syndrome (IBS), especially IBS-diarrhea (IBS-D), affects approximately 9-20% of the population worldwide. Classical treatments for IBS usually result in some side effects and intestinal microbial disorders, which inhibit the clinical effects. Natural edible medicines with beneficial effects and few side effects have received more attention in recent years. Puerarin is the main active ingredient in pueraria and has been used in China to treat splenasthenic diarrhea and as a natural food in folk medicine for hundreds of years. However, there have been no reports of using puerarin in the treatment of IBS-D, and the underlying mechanism is also still unclear. In this study, a comprehensive model that could reflect the symptoms of IBS-D was established by combining neonatal maternal separation (NMS) and adult colonic acetic acid stimulation (ACAAS) in rats. The results showed that puerarin could reverse the abdominal pain and diarrhea in IBS-D rats. The therapeutic effect was realized by regulating the richness of the gut microbiota to maintain the stabilization of the intestinal micro-ecology. Furthermore, the possible mechanism might be related to the activity of the hypothalamic-pituitary-adrenal (HPA) axis by the suppressed expression of corticotropin-releasing hormone receptor (CRF) 1. At the same time, intestinal function was improved by enhancing the proliferation of colonic epithelial cells by upregulating the expression of p-ERK/ERK and by repairing the colonic mucus barrier by upregulating occludin expression. All these results suggest that puerarin could exert excellent therapeutic effects on IBS-D.

A novel two-dimensional coordination polymer with a negatively charged framework named {[(CH3)2NH2][Zn2(L)2]·DMF}n (1) was solvothermally synthesized via the assembly of Zn(II) ions with the organic ligand H3L (2-(3,5-dicarboxylphenyl)-6-carboxyl-benzimidazole). 1 was characterized by IR spectroscopy, thermogravimetry, single-crystal, and powder X-ray diffraction methods. 1 possesses a 1D rectangle channel decorated by abundant uncoordinated imidazole N atoms and carboxylate O atoms, and is a better CO2 adsorbent and promising CO2/CH4 selective material, suggesting potential application in gas separation. Moreover, 1 can also serve as a multi-responsive sensing material for detecting nitrobenzene (NB) and Cr2O72−via a luminescence quenching effect with a low detection limit, and the mechanisms of the quenching effect and sensing properties of 1 are discussed in detail.

Precartilaginous stem cells (PCSCs) are able to initiate chondrocyte and bone development. The present study aimed to investigate the role of miR-143 and the underlying mechanisms involved in PCSC proliferation. In a rat growth plate injury model, tissue from the injury site was collected and the expression of miR-143 and its potential targets was determined. PCSCs were isolated from the rabbits' distal epiphyseal growth plate. Cell viability, DNA synthesis, and apoptosis were determined with MTT, BrdU, and flow cytometric analysis, respectively. Real time PCR and western blot were performed to detect the mRNA and protein expression of the indicated genes. Indian hedgehog (IHH) was identified as a target gene for miR-143 with luciferase reporter assay. Decreased expression of miR-143 and increased expression of IHH gene were observed in the growth plate after injury. miR-143 mimics decreased cell viability and DNA synthesis and promoted apoptosis of PCSCs. Conversely, siRNA-mediated inhibition of miR-143 led to increased growth and suppressed apoptosis of PCSCs. Transfection of miR-143 decreased luciferase activity of wild-type IHH but had no effect when the 3'-UTR of IHH was mutated. Furthermore, the effect of miR-143 overexpression was neutralized by overexpression of IHH. Our study showed that miR-143 is involved in growth plate behavior and regulates PCSC growth by targeting IHH, suggesting that miR-143 may serve as a novel target for PCSC-related diseases.

Two new metal–organic frameworks (MOFs), formulated as [Cd3(L)2(H2O)2]·2H2O (1) and [Zn2(L)(OH)(H2O)]·2DMA (2, DMA = N,N-dimethylacetamide), were first constructed via an unsymmetrical N-heterocyclic 5-((4-carboxypyridin-2-yl)oxy)isophthalic acid (H3L) ligand. Then, a proportion of the Zn(II) ions of 2 were substituted by fine-tuning the contents of Co(II) ions to obtain two new isomers, Co1-MOF 2 and Co2-MOF 2, the successful doping of which can be proved by PXRD, IR spectra, ICP, XPS, and SEM. The luminescent experiments suggested that complex 1 should be a good detector for detecting Fe3+ and Cr2O72− ions. More remarkably, the Co-rich MOF materials have increased gas capture for CO2 and CH4 compared to that of the Co-free isomer 2, and the absorption amount of CO2 and CH4 may rise with the increasing content of Co(II) ions in the system at higher pressure and lower temperature.

Toonayunnanaes A-E (1-5), five B-seco limonoids, along with five known compounds (6-10) were isolated from the bark of Toona ciliata. Compound 1 is a limonoid with a e-7(8)-lactone in the B ring, and compound 2 possesses a 1,14-oxygen bridge and a 15-OH. Their structures were elucidated by extensive spectroscopic analysis including 1D and 2D NMR, and HRESIMS. Compound 1 exhibited significant inhibition effect of NO production in LPS-stimulated RAW264.7 macrophages with an IC50 value of 10.94 ± 0.08 μM.

Sepsis is life-threatening organ dysfunction caused by an imbalance in the body's response to infection and acute lung injury (ALI) related to sepsis is a common complication. The rapid morbidity and high mortality associated with sepsis is a significant clinical problem facing critical care medicine. Inflammation plays a vital role in the occurrence of sepsis. Notably, the body produces different immune cells and pro-inflammatory factors to clear pathogens. However, excessive inflammation can damage multiple tissues and organs when it fails to resolve in time. Additionally, lymphatic vessels could effectively transfer inflammatory cells and factors away from tissues and into blood circulation, thereby reducing damage, and promoting the resolution of inflammation. Therefore, any dysfunction and/or destruction of the lymphatic system may result in lymphedema followed by inflammatory storms and eventual sepsis. Consequently, the present study aimed to review and highlight the role of lymphatic vessels in related body tissues and organs during sepsis and other associated diseases.

To observe the effects and safety of Tongyan Spray (通咽喷雾剂) on the range and time of hyoid motion in patients with ischemic post-stroke dysphagia. Seventy-two patients with ischemic post-stroke dysphagia were selected and randomly assigned to a treatment group (36 cases) and a control group (36 cases) by a random number table from January 2013 to October 2014. All patients swallowed 4 kinds of barium meals with different traits respectively, and each patient underwent video fluoroscopy (VF) examination twice. In the treatment group, Tongyan Spray was sprayed to the pharynx on both sides and the middle part once respectively. The spray was applied 30 min before the second examination. Purified water at room temperature was used as placebo in the control group. The changes in the range and time of hyoid motion in both groups were observed before and after treatment. Six patients dropped out in each group, and 60 patients completed the study and were included in the final analysis. Significant improvement was observed in the range of superior hyoid excursion distance and the time of hyoid motion in the treatment group compared with the control group (P

A new andirobin-type limonoid with modified furan ring, khaysenelide K (1), together with a known analogue (2), was isolated from the stem barks of Khaya senegalensis. The structure and absolute configuration of 1 were elucidated by a combination of 1D and 2D NMR, HRESIMS, and single-crystal X-ray diffraction using mirror Cu-Kα radiation. Compound 1 showed moderate NO inhibitory activity in LPS-activated RAW 264.7 macrophages with IC50 value of 27.74 ± 0.68 μM.[Formula: see text].

Metal-organic frameworks (MOFs) with zeolitic structure process fantastic structural metrics and display excellent applications in many aspects; however, they are difficult to assemble. Herein, on the basis of a tetrahedral Zn

Hypertension is a public health problem globally. Understanding the perceived challenges of low-income older people populations with chronic disease is an obstacle the world is facing today.To explore perceived challenges of self-management in low-income older people with hypertension.Data were collected in three communities from September 2019 to October 2019 by semi-structured interviews. Interviews were audio-taped by digital voice recorder and analysed according to Colaizzi's seven steps.Participants demonstrated perceived challenges concerning hypertension self-management. Six themes were identified: hypertension belief bias, family dysfunction, deep-rooted habit, elder self-neglect, medical informatization and supportive health policy. Each theme was identified with several subthemes.Findings implied that most of the low-income older people lacked self-management behaviours. Future research is needed to address perceived challenges related to self-management behaviour for patients with hypertension worldwide.

P53 prognostic cut-off values differ between studies of mantle cell lymphoma (MCL), and its immunohistochemistry (IHC) interpretation is still based on semiquantitative estimation, which might be inaccurate. This study aimed to investigate the optimal cut-off value for p53 in predicting prognosis of patients with MCL and the possible use of computer image analysis to identify the positive rate of p53. We calculated p53 positive rate using QuPath software and compared it with the data obtained by manual counting and semiquantitative estimation. Survival curves were generated by using the Youden index and the Kaplan-Meier method. The chi-squared (χ2) test was used to compare MIPI, Ann Arbor stage, and cell morphology with p53. Spearman rank correlation test and Bland-Altman analysis were used to compare manual counting, computer image analysis and semiquantitative estimation, as well as the consistency between different observers. The optimal cut-off value of p53 for predicting prognosis was 20% in MCL patients. Patients with p53 ≥ 20% had a significantly worse overall survival (OS) than those with p53 20% (P 0.0001). MCL patients with MIPI intermediate to high risk, Ann Arbor stage III-IV, and blastoid/pleomorphic variant cell morphology had more p53 ≥ 20%. There was a strong correlation between computer image analysis and manual counting of p53 from the same areas in MCL tissues (Spearman's rho = 0.966, P 0.0001). The results of computer analysis are completely consistent between observers, and computer image analysis of Ki-67 can predict the prognosis of MCL patients. MCL patients with p53 ≥ 20% had a shorter OS and a tendency for MIPI intermediate to high risk, Ann Arbor stage III-IV, and blastoid/pleomorphic variant. Computer image analysis could determine the actual positive rate of p53 and Ki-67 and is a more attractive alternative than semiquantitative estimation in MCL.