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The quality safety risks and quality management issues of traditional fermented meat products were analyzed. This paper put forward suggestions on increasing research and development efforts, accelerating the knowledge benefit transformation process, standardizing the standard system, refining supervision standards, standardizing workshop production, optimizing product markets, strengthening the awareness of social participation, and promoting social co-governance, in order to improve the overall quality and safety level of the traditional fermented meat products industry.

After phosphate treatment, the surface of mechanical parts has color differences of film, roughness and no film, and the properties of phosphating film could not meet the process requirements. Through comparison and analysis of literature, it was found that the physical or chemical changes took place on the surface of parts while forming parts by various processing methods, which meant the surface structure, surface composition, surface stress and other states of the parts were changed; the differences of surface state had different effects on phosphating reaction rate. Therefore, different pretreatment methods should be adopted for various surface states during phosphate treatment of mechanical parts to improve the phosphating film formation condition. In this way, uniform phosphating film could be formed on the surface of parts.

Abstract Background RNA‐binding motif protein 24 (RBM24) functions as a splicing regulator, which is critical for organ development and is dysregulated in human cancers. Here, we aim to uncover the biological function of RBM24 in colorectal tumourigenesis. Methods Xenograft tumour model, Rbm24 knockout and Apcmin/+ mouse models were utilised. Colorectal cancer cells overexpressing or silencing RBM24 were established. RNA immunoprecipitation (RIP) assay was conducted to detect protein‐RNA associations. Gene expression was measured by immunohistochemistry, western blotting, or quantitative PCR (qPCR). Results Rbm24‐knockout mice developed spontaneous colorectal adenomas with lower expression of phosphatase and tensin homolog (PTEN). Immunohistochemical staining for the proliferation markers Ki‐67 and pHH3 and BrdU assay showed intestinal hyperplasia in Rbm24‐knockout mice compared to wild‐type mice. RBM24 expression in colorectal adenoma tissues of Apcmin/+ mouse was downregulated compared with adjacent normal samples and was positively correlated with PTEN expression. In vitro, RBM24 overexpression suppressed cell proliferation, migration, invasion and increased sensitivity to 5‐FU or cisplatin in CRC cells. Mechanistically, RBM24 maintained PTEN mRNA stability by directly binding to the GT‐rich region at positions 8101–8251 in the 3′‐UTR of PTEN mRNA, prolonging the half‐life of PTEN mRNA, thereby increasing PTEN expression. Hence, low expression of RBM24 downregulated PTEN mRNA, causing the activation of PI3K‐Akt signalling in CRC cells. Furthermore, RBM24 expression in CRC tissues was lower than adjacent normal samples. RBM24 expression was positively correlated with PTEN expression and negatively correlated with Ki‐67 level. CRC patients with high RBM24 expression had a favourable outcome. Conclusions Taken together, RBM24 expression is markedly lower in colorectal tumours than in para‐carcinoma tissues. Rbm24‐knockout mice develop spontaneous colorectal adenomas. RBM24 directly binds and stabilises PTEN mRNA, which could cause the suppression of CRC cell proliferation, migration and invasion, thereby repressing colorectal tumourigenesis. These findings support the tumour‐suppressive role of RBM24. Targeting RBM24 holds strong promise for the diagnosis and treatment of CRC.

The compressive stress relaxation behaviors in three directions of beech (Fagus orientalis) were studied by experiments, and predicted by mechanical model and finite element method. Firstly, short-term (3 hours) compressive stress relaxation experiments were carried out in longitudinal (L), radical (R) and tangential (T) directions of beech, and then the experimental data was fitted by mechanical model with two single Maxwell bodies in parallel connection. Secondly, the method of predicting the long-term (12 hours) stress relaxation behaviors of beech based on the finite element method was studied using the experimental data of short-term stress relaxation. Finally, the long-term stress relaxation behaviors in three directions of beech were investigated by experiments, mechanical model and finite element method respectively, and the results of them were compared. The results showed that stress relaxation behaviors of beech were different in three directions, and the short-term stress relaxation in L was much smaller than those in R and T directions under the same load. Besides, the mechanical model with two single Maxwell bodies in parallel connection was able to be predict the short-term relaxation behaviors of beech in three directions with correlation coefficients beyond 0.99, but it did not work in long-term relaxation. In addition, the errors of FEM were smaller than those of the mechanical model compared with the results of experiments in the long-term stress relaxation, and the errors of the FEM were approximately 8% in L and 20% in R and T directions, which were all accepted in the field of wood engineer. This study will contributes to predict the long-term relaxation behaviors of wood products and wooden structures based on the FEM.