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1. Single-cell and spatial transcriptome analyses reveal tertiary lymphoid structures linked to tumour progression and immunotherapy response in nasopharyngeal carcinoma

Author

Liu, Yang, Ye, Shuang-Yan, He, Shuai, Chi, Dong-Mei, Wang, Xiu-Zhi, Wen, Yue-Feng, Ma, Dong, Nie, Run-Cong, Xiang, Pu, Zhou, You, Ruan, Zhao-Hui, Peng, Rou-Jun, Luo, Chun-Ling, Wei, Pan-Pan, Lin, Guo-Wang, Zheng, Jian, Cui, Qian, Cai, Mu-Yan, Yun, Jing-Ping, Dong, Junchao, Mai, Hai-Qiang, Xia, Xiaojun, and Bei, Jin-Xin

Published
2024
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4. Low value of whole-body dual-modality [18f]fluorodeoxyglucose positron emission tomography/computed tomography in primary staging of stage I–II nasopharyngeal carcinoma: a nest case-control study

Author

Xiao, Bei-Bei, Chen, Qiu-Yan, Sun, Xue-Song, Li, Ji-Bin, Luo, Dong-hua, Sun, Rui, Lin, Da-Feng, Zhang, Xu, Fan, Wei, Lv, Xiao-Fei, Han, Lu-Jun, Wen, Yue-Feng, Yuan, Li, Guo, Shan-Shan, Liu, Li-Ting, Liu, Sai-Lan, Tang, Qing-Nan, Liang, Yu-Jing, Li, Xiao-Yun, Lin, Chao, Guo, Ling, Mai, Hai-Qiang, and Tang, Lin-Quan

Published
2021
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5. The Association Between the Development of Radiation Therapy, Image Technology, and Chemotherapy, and the Survival of Patients With Nasopharyngeal Carcinoma: A Cohort Study From 1990 to 2012

Author

Sun, Xue-Song, Liu, Sai-Lan, Luo, Mei-Juan, Li, Xiao-Yun, Chen, Qiu-Yan, Guo, Shan-Shan, Wen, Yue-Feng, Liu, Li-Ting, Xie, Hao-Jun, Tang, Qing-Nan, Liang, Yu-Jing, Yan, Jin-Jie, Lin, Da-Feng, Bi, Ming-min, Liu, Ying, Liang, Yu-fan, Ma, Jun, Tang, Lin-Quan, and Mai, Hai-Qiang

Published
2019
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8. Identifying optimal candidates for local treatment of the primary tumor among patients with de novo metastatic nasopharyngeal carcinoma: a retrospective cohort study based on Epstein–Barr virus DNA level and tumor response to palliative chemotherapy

Author

Sun, Xue-Song, Liu, Li-Ting, Liu, Sai-Lan, Guo, Shan-Shan, Wen, Yue-Feng, Xie, Hao-Jun, Tang, Qing-Nan, Liang, Yu-Jing, Li, Xiao-Yun, Yan, Jin-Jie, Ma, Jun, Chen, Qiu-Yan, Tang, Lin-Quan, and Mai, Hai-Qiang

Published
2019
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9. Retraction notice to “Endogenous production of C–C motif chemokine ligand 2 by nasopharyngeal carcinoma cells drives radioresistance-associated metastasis” [Canc. Lett. 468 (2020) 27–40]

Author

Guo, Shan-Shan, primary, Liu, Rui, additional, Wen, Yue-Feng, additional, Liu, Li-Ting, additional, Yuan, Li, additional, Li, Yan-Xian, additional, Lie, Yang, additional, Hao, Wen-Wen, additional, Peng, Jing-Yun, additional, Chen, Dan-Ni, additional, Tang, Qing-Nan, additional, Sun, Xue-Song, additional, Guo, Ling, additional, Mo, Hao-Yuan, additional, Qian, Chao-Nan, additional, Zeng, Mu-Sheng, additional, Bei, Jin-Xin, additional, Sun, Shu-Yang, additional, Chen, Qiu-Yan, additional, Tang, Lin-Quan, additional, and Mai, Hai-Qiang, additional

Published
2023
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12. Rab1A promotes cancer metastasis and radioresistance through activating GSK-3β/Wnt/β-catenin signaling in nasopharyngeal carcinoma

Author

Yang, Xian-Zi, Chen, Xi-Min, Zeng, Li-Si, Deng, Jin, Ma, Lei, Jin, Chuan, Wang, Ren, Wang, Meng-He, Wen, Yue-Feng, Wu, Xiao-Liang, Wang, Hui-Yun, and Cui, Shu-Zhong

Subjects
Adult, Male, Epithelial-Mesenchymal Transition, Glycogen Synthase Kinase 3 beta, Nasopharyngeal Carcinoma, Rab1A, Nasopharyngeal Neoplasms, Middle Aged, Radiation Tolerance, radioresistance, Gene Expression Regulation, Neoplastic, rab1 GTP-Binding Proteins, Cell Movement, GSK-3β/Wnt/β-catenin signaling, Cell Line, Tumor, metastasis, Humans, Female, Neoplasm Invasiveness, Phosphorylation, Wnt Signaling Pathway, beta Catenin, Research Paper
Abstract

Many articles have reported that Rab1A was overexpressed in a variety of human cancers and involved in tumor progression and metastasis. However, the biological function and molecular mechanism of Rab1A in nasopharyngeal carcinoma (NPC) remained unknown until now. Here we found that Rab1A overexpression is a common event and was positively associated with distant metastasis and poor prognosis of NPC patients. Functionally, Rab1A depletion inhibited the migration and EMT phenotype of NPC cells, whereas Rab1A overexpression led to the opposite effect. Furthermore, we reveal an important role for Rab1A protein in the induction of radioresistance via regulating homologous recombination (HR) signaling pathway. Mechanistically, Rab1A activated Wnt/β-catenin signaling by inhibiting the activity of GSK-3β via phosphorylation at Ser9. Then Wnt/β-catenin signaling induced NPC cells radioresistance and metastasis through nuclear translocation of β-catenin and transcription upregulation of HR pathway-related and EMT-related genes expression. In general, this study shows that Rab1A may serve as a potential biomarker for predicting prognosis in NPC patients. Targeting Rab1A and Wnt/β-catenin signaling may hold promise to overcome NPC radioresistance.

Published
2020

15. Geriatric nutritional risk index as an independent prognostic factor in locally advanced nasopharyngeal carcinoma treated using radical concurrent chemoradiotherapy: a retrospective cohort study

Author

Tang, Qing-Nan, primary, Qiu, Hui-Zhi, additional, Sun, Xiao-Qing, additional, Guo, Shan-Shan, additional, Liu, Li-Ting, additional, Wen, Yue-Feng, additional, Liu, Sai-Lan, additional, Xie, Hao-Jun, additional, Liang, Yu-Jing, additional, Sun, Xue-Song, additional, Li, Xiao-Yun, additional, Yan, Jin-Jie, additional, Yang, Jin-Hao, additional, Wen, Dong-Xiang, additional, Guo, Ling, additional, Tang, Lin-Quan, additional, Chen, Qiu-Yan, additional, and Mai, Hai-Qiang, additional

Published
2021
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16. [Rules of acupoint selection and drug use in clinical treatment of hypertension with acupoint application therapy]

Author

Ya-Qi, He, Bing-Xue, Liang, Wen-Yue, Feng, and Shao-Xiang, Xian

Subjects
Hypertension, Acupuncture Therapy, Humans, Meridians, Acupuncture Points
Abstract

To explore the rules of acupoint selection and drug use in treatment of hypertension with acupoint application therapy.The articles of the clinical research of hypertension treated with acupoint application therapy were retrieved from Chinese journal full-text database (CNKI), VIP database (VIP) and Wanfang databases from the time of establishment to January 20, 2019. The database was set up with Microsoft Excel 2010. Using the cloud platform of the ancient and modern medicine record, the frequency statistical and clustering analyses were conducted.A total of 117 articles were collected, including 191 prescriptions, 60 aucpoints and 236 kinds of herbal drugs. It was found in the frequency statistical analysis that the top 6 acupoints in use frequency were Yongquan (KI 1), Quchi (LI 11), Taichong (LR 3), Shenque (CV 8), Sanyinjiao (SP 6) and Neiguan (PC 6). According to the correlation analysis, corresponding to these top 6 acupoints, the pairs of acupoints were Sanyinjiao (SP 6) and Yongquan (KI 1), Shenque (CV 8) and Yongquan (KI 1), Neiguan (PC 6) and Yongquan (KI 1), Zusanli (ST 36) and Sanyinjiao (SP 6), Sanyinjiao (SP 6) and Neiguan (PC 6) with Yongquan (KI 1), as well as Yongquan (KI 1) and Neiguan (PC 6) with Sanyinjiao (SP 6). The dominant meridians were the kidney meridian, the conception vessel and the bladder meridian. The special acupoints referred toIn treatment of hypertension with acupoint application therapy, the commonly used single acupoint is Yongquan (KI 1), which is generally combined with Sanyinjiao (SP 6), Shenque (CV 8), Neiguan (PC 6) and Zusanli (ST 36). The correlation is emphasized on the application of special acupoints, meridian points and

Published
2020

17. Appendix_table_1 – Supplemental material for Induction chemotherapy followed by radiotherapy versus concurrent chemoradiotherapy in the treatment of different risk locoregionally advanced nasopharyngeal carcinoma

Author

Liu, Li-Ting, Liang, Yu-Jing, Guo, Shan-Shan, Mo, Hao-Yuan, Guo, Ling, Wen, Yue-Feng, Xie, Hao-Jun, Qing-Nan Tang, Sun, Xue-Song, Sai-Lan Liu, Li, Xiao-Yun, Jin-Hao Yang, Zhen-Chong Yang, Lin-Quan Tang, Chen, Qiu-Yan, and Mai, Hai-Qiang

Subjects
110203 Respiratory Diseases, FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, Appendix_table_1 for Induction chemotherapy followed by radiotherapy versus concurrent chemoradiotherapy in the treatment of different risk locoregionally advanced nasopharyngeal carcinoma by Li-Ting Liu, Yu-Jing Liang, Shan-Shan Guo, Hao-Yuan Mo, Ling Guo, Yue-Feng Wen, Hao-Jun Xie, Qing-Nan Tang, Xue-Song Sun, Sai-Lan Liu, Xiao-Yun Li, Jin-Hao Yang, Zhen-Chong Yang, Lin-Quan Tang, Qiu-Yan Chen and Hai-Qiang Mai in Therapeutic Advances in Medical Oncology

Published
2020
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18. Efficacy of Transnasal Endoscopic Fine‐Needle Aspiration Biopsy in Diagnosing Submucosal Nasopharyngeal Carcinoma

Author

Tang, Qing‐Nan, primary, Tang, Lin‐Quan, additional, Liu, Li‐Ting, additional, Wen, Dong‐Xiang, additional, Lu, Zi‐Jian, additional, Ou, Guo‐Ping, additional, Yan, Jin‐Jie, additional, Yang, Jin‐Hao, additional, Li, Ji‐Bin, additional, Wen, Yue‐Feng, additional, Guo, Shan‐Shan, additional, Liu, Sai‐Lan, additional, Xie, Hao‐Jun, additional, Sun, Xue‐Song, additional, Li, Xiao‐Yun, additional, Chen, Qiu‐Yan, additional, and Mai, Hai‐Qiang, additional

Published
2021
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19. Nomogram for the prediction of primary distant metastasis of nasopharyngeal carcinoma to guide individualized application of FDG PET/CT

Author

Xiao, Bei-Bei, primary, Lin, Da-Feng, additional, Sun, Xue-Song, additional, Zhang, Xu, additional, Guo, Shan-Shan, additional, Liu, Li-Ting, additional, Luo, Dong-hua, additional, Sun, Rui, additional, Wen, Yue-Feng, additional, Li, Ji-Bin, additional, Lv, Xiao-Fei, additional, Han, Lu-Jun, additional, Yuan, Li, additional, Liu, Sai-Lan, additional, Tang, Qing-Nan, additional, Liang, Yu-Jing, additional, Li, Xiao-Yun, additional, Guo, Ling, additional, Chen, Qiu-Yan, additional, Fan, Wei, additional, Mai, Hai-Qiang, additional, and Tang, Lin-Quan, additional

Published
2021
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21. Induction chemotherapy followed by radiotherapy versus concurrent chemoradiotherapy in the treatment of different risk locoregionally advanced nasopharyngeal carcinoma

Author

Liu, Li-Ting, primary, Liang, Yu-Jing, additional, Guo, Shan-Shan, additional, Mo, Hao-Yuan, additional, Guo, Ling, additional, Wen, Yue-Feng, additional, Xie, Hao-Jun, additional, Tang, Qing-Nan, additional, Sun, Xue-Song, additional, Liu, Sai-Lan, additional, Li, Xiao-Yun, additional, Yang, Jin-Hao, additional, Yang, Zhen-Chong, additional, Tang, Lin-Quan, additional, Chen, Qiu-Yan, additional, and Mai, Hai-Qiang, additional

Published
2020
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22. RETRACTED: Endogenous production of C–C motif chemokine ligand 2 by nasopharyngeal carcinoma cells drives radioresistance-associated metastasis

Author

Guo, Shan-Shan, primary, Liu, Rui, additional, Wen, Yue-Feng, additional, Liu, Li-Ting, additional, Yuan, Li, additional, Li, Yan-Xian, additional, Li, Yang, additional, Hao, Wen-Wen, additional, Peng, Jing-Yun, additional, Chen, Dan-Ni, additional, Tang, Qing-Nan, additional, Sun, Xue-Song, additional, Guo, Ling, additional, Mo, Hao-Yuan, additional, Qian, Chao-Nan, additional, Zeng, Mu-Sheng, additional, Bei, Jin-Xin, additional, Sun, Shu-Yang, additional, Chen, Qiu-Yan, additional, Tang, Lin-Quan, additional, and Mai, Hai-Qiang, additional

Published
2020
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23. Additional file 1: of Maximal standard uptake values of 18F-fluoro-2-deoxy-D-glucose positron emission tomography compared with Epstein-Barr virus DNA as prognostic indicators in de novo metastatic nasopharyngeal carcinoma patients

Author

Sun, Xue-Song, Liang, Yu-Jing, Sai-Lan Liu, Chen, Qiu-Yan, Guo, Shan-Shan, Wen, Yue-Feng, Liu, Li-Ting, Xie, Hao-Jun, Qing-Nan Tang, Li, Xiao-Yun, Yan, Jin-Jie, Lin-Quan Tang, and Mai, Hai-Qiang

Abstract

Table S1. Follow-up durations of different subgroups (DOCX 51 kb)

Published
2019
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24. Additional file 1: of Identifying optimal candidates for local treatment of the primary tumor among patients with de novo metastatic nasopharyngeal carcinoma: a retrospective cohort study based on Epsteinâ Barr virus DNA level and tumor response to palliative chemotherapy

Author

Sun, Xue-Song, Liu, Li-Ting, Sai-Lan Liu, Guo, Shan-Shan, Wen, Yue-Feng, Xie, Hao-Jun, Qing-Nan Tang, Liang, Yu-Jing, Li, Xiao-Yun, Yan, Jin-Jie, Ma, Jun, Chen, Qiu-Yan, Lin-Quan Tang, and Mai, Hai-Qiang

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, parasitic diseases, bacterial infections and mycoses, hormones, hormone substitutes, and hormone antagonists
Abstract

Table S1. Relationship between EBV DNA levels after PCT and tumor response to PCT. (DOCX 49 kb)

Published
2019
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25. Subdivision of Nasopharyngeal Carcinoma Patients with Bone-Only Metastasis at Diagnosis for Prediction of Survival and Treatment Guidance

Author

Sun, Xue-Song, primary, Liang, Yu-Jing, additional, Liu, Sai-Lan, additional, Chen, Qiu-Yan, additional, Guo, Shan-Shan, additional, Wen, Yue-Feng, additional, Liu, Li-Ting, additional, Xie, Hao-Jun, additional, Tang, Qing-Nan, additional, Li, Xiao-Yun, additional, Yan, Jin-Jie, additional, Tang, Lin-Quan, additional, and Mai, Hai-Qiang, additional

Published
2019
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26. Patterns of Failure and Survival Trends in 3,808 Patients with Stage II Nasopharyngeal Carcinoma Diagnosed from 1990 to 2012: A Large-Scale Retrospective Cohort Study

Author

Sun, Xue-Song, primary, Liu, Di-Han, additional, Liu, Sai-Lan, additional, Chen, Qiu-Yan, additional, Guo, Shan-Shan, additional, Wen, Yue-Feng, additional, Liu, Li-Ting, additional, Xie, Hao-Jun, additional, Tang, Qing-Nan, additional, Liang, Yu-Jing, additional, Li, Xiao-Yun, additional, Yan, Jin-Jie, additional, Hong, Ming-Huang, additional, Ma, Jun, additional, Tang, Lin-Quan, additional, and Mai, Hai-Qiang, additional

Published
2019
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27. Individualized concurrent chemotherapy by pretreatment plasma Epstein‐Barr viral DNA in II‐III stage nasopharyngeal carcinoma: A propensity score matching analysis using a large cohort

Author

Sun, Xue‐Song, primary, Chen, Wen‐Hui, additional, Liu, Sai‐Lan, additional, Liang, Yu‐Jing, additional, Chen, Qiu‐Yan, additional, Guo, Shan‐Shan, additional, Wen, Yue‐Feng, additional, Liu, Li‐Ting, additional, Xie, Hao‐Jun, additional, Tang, Qing‐Nan, additional, Li, Xiao‐Yun, additional, Yan, Jin‐Jie, additional, Mai, Hai‐Qiang, additional, and Tang, Lin‐Quan, additional

Published
2019
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29. Ten-year outcomes of survival and toxicity for a phase III randomised trial of concurrent chemoradiotherapy versus radiotherapy alone in stage II nasopharyngeal carcinoma

Author

Li, Xiao-Yun, primary, Chen, Qiu-Yan, additional, Sun, Xue-Song, additional, Liu, Sai-Lan, additional, Yan, Jin-Jie, additional, Guo, Shan-Shan, additional, Liu, Li-Ting, additional, Xie, Hao-Jun, additional, Tang, Qing-Nan, additional, Liang, Yu-Jing, additional, Wen, Yue-Feng, additional, Guo, Ling, additional, Mo, Hao-Yuan, additional, Chen, Ming-Yuan, additional, Sun, Ying, additional, Ma, Jun, additional, Tang, Lin-Quan, additional, and Mai, Hai-Qiang, additional

Published
2019
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30. The impact of Adult Comorbidity Evaluation-27 on the clinical outcome of elderly nasopharyngeal carcinoma patients treated with chemoradiotherapy or radiotherapy: a matched cohort analysis

Author

Wen, Yue-Feng, primary, Sun, Xue-Song, additional, Yuan, Li, additional, Zeng, Li-Si, additional, Guo, Shan-Shan, additional, Liu, Li-Ting, additional, Lin, Chao, additional, Xie, Hao-Jun, additional, Liu, Sai-Lan, additional, Li, Xiao-Yun, additional, Zhang, Yi-Bin, additional, Huang, Wen-Jin, additional, Peng, Hai-Hua, additional, Liao, Zhi-Wei, additional, Song, Xian-Lu, additional, Tang, Qing-Nan, additional, Liang, Yu-Jing, additional, Yan, Jin-Jie, additional, Yang, Jin-Hao, additional, Yang, Zhen-Chong, additional, Chen, Qiu-Yan, additional, Lin, Xiao-Dan, additional, Tang, Lin-Quan, additional, and Mai, Hai-Qiang, additional

Published
2019
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34. [Evaluation of a pilot study on needle and syringe exchange program among injecting drug users in a community in Guangdong, China]

Author

Peng, Lin, Zi-Fan, Fan, Fang, Yang, Zun-You, Wu, Ye, Wang, Yong-Ying, Liu, Zhong-Qiang, Ming, Wen-Jie, Li, Wei, Luo, Xiao-Bing, Fu, Xin-Rong, Mai, Rui-Heng, Xu, Wen-Yue, Feng, and Qun, He

Subjects
Adult, Male, Needle-Exchange Programs, China, Humans, Female, HIV Infections, Needle Sharing, Pilot Projects, Substance Abuse, Intravenous, Health Education, Program Evaluation
Abstract

To evaluate the feasibility and effectiveness of needle and syringe exchange program among a community of injecting drug users (IDUs) on AIDS prevention.A quasi-experiment design was used in a controlled community intervention study. Needle and syringe exchange program was implemented for 10 months in IDUs of an intervention community, including peer education and health education, provision of free needles and syringes, and collecting back of used needles and syringes by trained peer educators and local health workers, whereas no intervention measure in a control community was instituted. Interviews with IDUs were conducted before and after intervention with a snowballing strategy to evaluate its effectiveness.A total of 428 and 429 IDUs were interviewed with structured questionnaire before and after intervention in intervention and control communities, respectively. Results revealed that awareness of HIV-related knowledge increased from 29.4% to 58.7% in the intervention community. Multivariate logistic regression analysis showed that awareness of HIV-related knowledge was higher in those who had read health education materials (OR = 2.93, 95% CI 2.12 - 4.04). As compared with the baseline data, frequency of sharing needles and syringes in past 30 days in the intervention community decreased from 48.9% to 20.4% in before intervention community (chi(2) = 41.02, P = 0.001), whereas there was no significant change in the control community. The causes of sharing needles and syringes in the intervention community included 'disable to get needle and syringe during the night', 'lack of needle and syringe when injecting at friend's home', 'not daring to buy needle and syringe for fear of being arrested' and 'no money to buy needle and syringe', declined markedly.Needle and syringe exchange program was feasible and effective in reducing their risky drug injecting behavior among IDUs in communities. Such strategy should be adopted in the country to reduce rapid spread of HIV.

Published
2004

36. Polymorphisms in the Endothelin-1 and Endothelin A Receptor Genes and Survival in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma

Author

Wen, Yue-Feng, primary, Qi, Bin, additional, Liu, Huai, additional, Mo, Hao-Yuan, additional, Chen, Qiu-Yan, additional, Li, Juan, additional, Huang, Pei-Yu, additional, Ye, Yan-Fang, additional, Zhang, Ying, additional, Deng, Man-Quan, additional, Guo, Xiang, additional, Hong, Ming-Huang, additional, Cao, Ka-Jia, additional, and Mai, Hai-Qiang, additional

Published
2011
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37. Maximal standard uptake values of 18F-fluoro-2-deoxy-D-glucose positron emission tomography compared with Epstein-Barr virus DNA as prognostic indicators in de novo metastatic nasopharyngeal carcinoma patients.

Author

Sun, Xue-Song, Liang, Yu-Jing, Liu, Sai-Lan, Chen, Qiu-Yan, Guo, Shan-Shan, Wen, Yue-Feng, Liu, Li-Ting, Xie, Hao-Jun, Tang, Qing-Nan, Li, Xiao-Yun, Yan, Jin-Jie, Tang, Lin-Quan, and Mai, Hai-Qiang

Subjects
POSITRON emission tomography, EPSTEIN-Barr virus, DNA viruses, MONEY, NASOPHARYNX tumors, RECEIVER operating characteristic curves
Abstract

Background: This study aimed to evaluate the prognostic value of maximal standard uptake values (SUVmax) of 18F-fluoro-2-deoxy-D-glucose positron emission tomography (PET) comparing with Epstein-Barr virus (EBV) DNA levels in de novo metastatic nasopharyngeal carcinoma (NPC) patients.Methods: From December 2006 to December 2016, 253 de novo metastatic NPC patients assessed by PET/ computed tomography were involved in current study. SUVmax-T, SUVmax-N, and SUVmax-M referred to the SUVmax at the primary tumor, cervical lymph nodes, and metastatic lesions respectively. Overall survival (OS) was the primary endpoint.Result: Patients who died during the follow-up had significantly higher SUVmax-N, SUVmax-M, and EBV DNA level than those in the patients who were alive. SUVmax-N and SUVmax-M were positively correlated with EBV DNA level. The cut-off values of SUVmax-T, SUVmax-N, SUVmax-M, and EBV DNA were 17.0, 12.7, and 6.9, and 13,800 copies/mL respectively, which were determined by receiver operating characteristic (ROC) curve analysis. Patients with elevated SUVmax-N, SUVmax-M, and EBV DNA levels had a lower 3-year OS rate. In multivariate analysis, the independent prognostic factors of OS included EBV DNA, metastatic site, and locoregional radiotherapy application, while SUVmax was not an independent prognostic factor.Conclusion: In de novo metastatic NPC patients, higher SUVmax-N and SUVmax-M were associated with worse prognosis. However, the predictive ability of SUVmax-N and SUVmax-M was poorer than that of EBV DNA. [ABSTRACT FROM AUTHOR]

Published
2019
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38. Endogenous production of C-C motif chemokine ligand 2 by nasopharyngeal carcinoma cells drives radioresistance-associated metastasis.

Author

Guo, Shan-Shan, Liu, Rui, Wen, Yue-Feng, Liu, Li-Ting, Yuan, Li, Li, Yan-Xian, Li, Yang, Hao, Wen-Wen, Peng, Jing-Yun, Chen, Dan-Ni, Tang, Qing-Nan, Sun, Xue-Song, Guo, Ling, Mo, Hao-Yuan, Qian, Chao-Nan, Zeng, Mu-Sheng, Bei, Jin-Xin, Sun, Shu-Yang, Chen, Qiu-Yan, and Tang, Lin-Quan

Subjects
*PROGRESSION-free survival, *METASTASIS, *AUTOCRINE mechanisms, *CARCINOMA, *CELLS
Abstract

Patients with recurrent nasopharyngeal carcinoma (NPC) have more co-existing distant metastasis than those of no-recurrence and are more likely to suffer distant metastasis after re-irradiation than patients with newly diagnosed NPC. However, the relationship between radioresistance and distant metastasis and the mechanisms involved in radioresistance-associated metastasis are still unclear. In this study, we proved that C-C motif chemokine ligand 2 (CCL2) expression was significantly elevated in HONE1-IR cells and recurrent NPC tumour. Inhibition of CCL2 enhanced sensitivity to radiotherapy in NPC cells. Moreover, autocrine CCL2 promoted NPC cell adaptive radioresistance, metastasis and epithelial-mesenchymal transition. Additionally, p53 activated CCL2 transcription. High CCL2 expression was highly associated with poorer locoregional recurrence free survival, progression free survival and overall survival in patients with newly diagnosed NPC. Notably, high CCL2 expression was an independent prognostic factor for distant metastasis free survival in recurrent NPC patients. Our results provide insights into the autocrine signalling mechanisms of CCL2 and suggest that inhibition of autocrine CCL2 may be a candidate treatment strategy for management of radioresistant NPC. [ABSTRACT FROM AUTHOR]

Published
2020
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39. High miR-3650 expression in nasopharyngeal carcinoma and its clinical prognostic values.

Author

Ruan Q, Yang XZ, Zhu L, He QJ, Zhu SY, Wen YF, and Ma L

Subjects
Adult, Female, Humans, Male, MicroRNAs genetics, Middle Aged, Nasopharyngeal Carcinoma genetics, Nasopharyngeal Carcinoma mortality, Nasopharyngeal Carcinoma pathology, Nasopharyngeal Neoplasms genetics, Nasopharyngeal Neoplasms mortality, Nasopharyngeal Neoplasms pathology, Prognosis, Survival Rate, Up-Regulation, Gene Expression Regulation, Neoplastic, MicroRNAs metabolism, Nasopharyngeal Carcinoma metabolism, Nasopharyngeal Neoplasms metabolism
Abstract

Background: A recent study has reported that miR-3650 expression was significant reduced in hepatocellular carcinoma and predicted poor prognosis. However, the role of miR-3650 in nasopharyngeal carcinoma (NPC) remains indefinite., Methods: Total 140 cases of NPCs were included in this study. The expression of miR-3650 was determined in NPC tissues and adjacent nontumor tissues using qRT-PCR. Then the relationship between miR-3650 expression and clinicopathological features as well as survival were analyzed., Results: The expression of miR-3650 was significant higher in NPC tissues than that in adjacent nontumor tissues (P <  0.001). High expression of miR-3650 was significant correlated with tumor progression and distant metastasis of NPC patients. And patients with high miR-3650 expression have much worse 5-year overall survival (OS) and 5-year progression-free survival (PFS) than those with low expression (all P <  0.0001). Furthermore, Cox regression analysis showed that miR-3650 was an independent risk predictor for OS and PFS in NPC patients (all P =  0.000)., Conclusion: Our results demonstrated for the first time that miR-3650 was markedly upregulated in NPC tissues and positively associated with tumor progression and poor survival, suggesting that miR-3650 may be a potential novel prognostic biomarker and therapeutic target for NPC patients., (Copyright © 2021 Elsevier GmbH. All rights reserved.)

Published
2021
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