Search

The mechanisms that mediate the spreading of neural and hormonal signals in corporal smooth muscle cells during erectile function were analyzed in experimentally diabetic Fischer 344 (F-344) rats. Analysis of diabetes-induced erectile dysfunction in F-344 rats indicated the presence of reduced penile reflexes and duration of intracavernous pressure (ICP) during variable levels of stimulation. However, reductions in the magnitude of ICP response in F-344 rats were reduced by daily insulin replacement.

Abstract: Herein, functionalized PEDOT films were prepared by incorporation of two electroactive species, ferrocenecarboxylic acid (Fc−) and ferricyanide (Fe(CN)6 4−) as doping anions during the electropolymerization of PEDOT at glassy carbon electrodes (GCEs) from aqueous solution. The electrochemically synthesized electroactive species-doped PEDOT films have been carefully characterized by scanning electron microscopy (SEM), FTIR and UV/Vis spectra and various electrochemical techniques. Such nanostructured films combined the advantages of PEDOT (high conductivity and stability) together with electroactive species (good electrochemical activity) and were applied as electrochemical sensors for simultaneous determination of vitamin B2 (VB2), vitamin B6 (VB6) and vitamin C (VC). The results showed that the oxidation peak currents of vitamins obtained at the GCEs modified with electroactive species-doped PEDOT films were much higher than those at the ClO4 −-doped PEDOT films and bare GCEs. The experiment results also illustrated that the sensors possessed high selectivity with no interference from other potential competing species. Moreover, the proposed sensors were successfully employed for the determination of vitamins in orange juice samples with satisfactory results. [Copyright &y& Elsevier]