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In the work, TiAlN for physical vapor deposition (PVD), multilayer TiN‐Al2O3‐TiCN‐TiN for chemical vapor deposition (CVD), and diamond‐like carbon (DLC) for plasma‐enhanced chemical vapor deposition (PECVD) were deposited on the cermet inserts. Characteristics and wear behaviors of the three coated cermets during dry cutting of 7075 aluminum alloys were observed. The results show that TiN‐Al2O3‐TiCN‐TiN coatings have highest adhesion strength and hardness. At the cutting speed of 1100 r/min, the depth of 0.2 mm, and the feed rate of 0.1 mm/r, the three coated inserts show the best wear‐resistant properties. In this case, TiN/Al2O3/TiCN/TiN shows the worst wear‐resistant properties (value of the flank wear [VBB] = 0.062 mm), while DLC coatings show the most excellent wear‐resistant properties (VBB = 0.046 mm). During the cutting of aluminum alloys, which have high plasticity and low melting point, adhesive wear dominate on the flank of the inserts. The thickest coating of TiN/Al2O3/TiCN/TiN results in the bluntest cutting edge, which form the most serious adhesive worn zone. For the TiAlN and DLC coatings, due to a smaller cutting force, the two coatings have much better wear resistance. Further, the self‐lubricating properties of DLC show excellent effect on protecting the inserts. Thus, the DLC‐coated cermets have the best wear‐resistant properties. Further, the TiAlN‐coated cermets have the widest wear‐affected zone while the DLC coating has the narrowest. [ABSTRACT FROM AUTHOR]

Introduction: Circular RNAs (circRNAs) are important biological molecules associated with the pathogenesis of multiple cancers., Objective: This work aimed to investigate the function and molecular mechanism of circ_0070203 in high-grade serous ovarian cystadenocarcinoma (HGSOC)., Methods: circRNA microarray was conducted to detect the circ_0070203 expression in HGSOC tissues. Bioinformatics analysis was used to find the binding sites between circ_0070203, miR- 370-3p and TGFβR2. Real-time quantitative reverse transcription PCR (RT-qPCR) was executed to detect the expressions of circ_0070203, miR-370-3p and TGFβR2 in HGSOC tissues and SKOV3 cells. Dual-luciferase reporter gene assay was used to validate the relationships between miR-370-3p and circ_0070203 or TGFβR2. Besides, transwell assays were conducted to assess the migrative, invasive abilities of ovarian cancer (OC) cells. Western blotting was adopted to detect the expression of epithelial-mesenchymal transition (EMT)-related proteins. The related patents were also studied during the research., Results: Circ_0070203 and TGFβR2 were upregulated, while miR-370-3p was downregulated in FIGO stage III-IV HGSOC tissues and SKOV-3 cell lines. circ_0070203 overexpression changed the expression of other EMT-related proteins and enhanced the migrative, invasive abilities of OC cells, while silencing circ_0070203 worked oppositely. Mechanistically, circ_0070203 could upregulate TGFβR2 expression in OC cells via sponging miR-370-3p., Conclusion: Circ_0070203 could promote the epithelial-mesenchymal transition, invasion, and metastasis of HGSOC via regulating the miR-370-3p/TGFβR2 axis. Our findings provided a potential biomarker for HGSOC therapy., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)