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176 results on '"Welty S"'

1. Initial results of recent HIV infection surveillance in Cambodia, 2020

Author

Ly, P.S., Soch, K., Ouk, V., Ngauv, B., Chea, C., Mom, C., Bora, C., Eng, B., Ly, V., Albalak, R., Yang, C., Ebrahim, S., Dobbs, T., Ernst, A., Welty, S., Stephens, S., Buback, L., Kiernan, B., and Suthar, A.

Subjects
Disease transmission -- Statistics -- Risk factors, HIV infection -- Statistics -- Risk factors, Health
Abstract

Background: Recent HIV infection surveillance can help to identify populations and geographies with active transmission. We compared risk factors among recent and long-term infections from the initial ten months of [...]

Published
2021
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9. Fetal lower urinary tract obstruction: proposal for standardized multidisciplinary prenatal management based on disease severity

Author

Ruano, R., Sananès, Nicolas, Wilson, C., Au, J., Koh, C. J., Gargollo, P., Shamshirsaz, A. A., Espinoza, J., Safdar, A., Moaddab, A., Meyer, N., Cass, D. L., Olutoye, O. O., Welty, S., Roth, D. R., Braun, M. C., Belfort, M. A., Biomatériaux et Bioingénierie (BB), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), and Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Objective: To present a single center experience of a standardized prenatal multidisciplinary management protocol for fetal lower urinary tract obstruction (LUTO) and to propose a classification of fetal LUTO based on disease severity. Methods: This was a retrospective cohort study of 25 consecutive fetal patients with prenatal diagnosis of primary LUTO. Fetal intervention was offered after evaluation by a multidisciplinary team. Analyses were conducted using Bayesian methodology to determine predictors of survival at 6 months postpartum. Odds ratios (ORs) with 95% credibility intervals are reported. Results: Fifteen (60.0%) of the 25 patients referred for assessment survived to postnatal evaluation. Fetal vesicoamniotic shunt was placed in 14 (56.0%) patients with 12 survivors. Multivariable analysis suggested that fetal intervention (OR, 6.97 (0.88-70.16), Pr(OR > 1) = 96.7%), anhydramnios (OR, 0.12 (0.04-0.35), Pr(OR < 1) = 99.9%), favorable fetal urine analysis (OR, 3.98 (0.63-25.15), Pr(OR > 1) = 92.7%) and absence of renal cortical cysts (OR, 3.9 (0.66-24.2), Pr(OR > 1) = 93.3%) were predictors of survival. Conclusions: Fetal intervention and fetal renal function were independently associated with postnatal survival of fetuses with LUTO. A classification based on the severity of disease is proposed. Copyright © 2015 ISUOG. Published by John Wiley & Sons Ltd. Keywords: cystoscopy; fetal lower urinary tract obstruction; fetal surgery; laser; posterior urethral valves; prenatal diagnosis; ultrasonography; vesicoamniotic shunt.

Published
2016

10. OP21.08: Longitudinal ultrasound assessment of lung vasculature in fetuses with congenital diaphragmatic hernia treated by endoscopic tracheal occlusion and controls

Author

Britto, I.S., primary, Sananes, N., additional, Olutoye, O.O., additional, Cass, D., additional, Sangi‐Haghpeykar, H., additional, Cassady, C., additional, Mehollin‐Ray, A., additional, Welty, S., additional, Belfort, M., additional, Lee, W., additional, and Ruano, R., additional

Published
2016
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12. Maternal Morbidity in Patients With Morbidly Adherent Placenta Treated With and Without a Standardized Multidisciplinary Approach

Author

Shamshirsaz, A.A., primary, Fox, K.A., additional, Salmanian, B., additional, Diaz-Arrastia, C.R., additional, Lee, W., additional, Baker, B.W., additional, Ballas, J., additional, Chen, Q., additional, Van Veen, T.R., additional, Javadian, P., additional, Sangi-Haghpeykar, H., additional, Zacharias, N., additional, Welty, S., additional, Cassady, C.I., additional, Moaddab, A., additional, Popek, E.J., additional, Rocky Hui, S.-K., additional, Teruya, J., additional, Bandi, V., additional, Coburn, M., additional, Cunningham, T., additional, Martin, S.R., additional, and Belfort, M.A., additional

Published
2016
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13. OP17.02: Predicting outcome in fetuses with isolated left‐sided CDH using multiple ultrasound parameters: a single centre study

Author

Sananes, N., primary, Akinkuotu, A., additional, Olutoye, O.O., additional, Cass, D., additional, Sangi‐Haghpeykar, H., additional, Lee, T., additional, Cassady, C., additional, Mehollin‐Ray, A., additional, Welty, S., additional, Fernandes, C., additional, Belfort, M.A., additional, Lee, W., additional, and Ruano, R., additional

Published
2015
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14. OC14.04: Quantification of liver herniation in fetuses with isolated congenital diaphragmatic hernia using two-dimensional ultrasonography

Author

Britto, I.S., primary, Sananes, N., additional, Cass, D.L., additional, Zamora, I., additional, Lee, T.C., additional, Olutoye, O., additional, Mehollin-Ray, A., additional, Welty, S., additional, Fernandes, C., additional, Belfort, M.A., additional, Lee, W., additional, Cassady, C., additional, and Ruano, R., additional

Published
2015
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16. OC07.04: Postnatal outcome in newborns with congenital diaphragmatic hernia associated with cardiac defects: a single center experience

Author

Javadian, P., primary, Ruano, R., additional, Shamshirsaz, A.A., additional, Cass, D., additional, Zamora, I., additional, Lee, T., additional, Cassady, C., additional, Mehollin‐Ray, A., additional, Welty, S., additional, Fernandes, C., additional, Ayres, N. A., additional, Maskati, S. A., additional, Kalin, J. A., additional, Belfort, M., additional, and Olutoye, O., additional

Published
2013
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17. OC18.04: Prenatal ultrasound and magnetic resonance imaging findings in fetuses with heart defect associated with congenital diaphragmatic hernia

Author

Javadian, P., primary, Shamshirsaz, A.A., additional, Cass, D., additional, Zamora, I., additional, Lee, T., additional, Cassady, C., additional, Ayres, N. A., additional, Mehollin‐Ray, A., additional, Fernandes, C., additional, Welty, S., additional, Kalin, J. A., additional, Maskati, S. A., additional, Olutoye, O., additional, Belfort, M., additional, and Ruano, R., additional

Published
2013
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22. La Revue de Médecine Interne

Author

Thévenot, T., primary, Nguyen-Khac, E., additional, Tilmant, L., additional, Tiry, C., additional, Welty, S., additional, Toutouch, M., additional, Merzoug, N., additional, Janicki, E., additional, and Cadranel, J.F., additional

Published
2003
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25. Maladie de Parkinson et achalasie

Author

Thévenot, T., primary, Cattan, S., additional, Nguyen-Khac, E., additional, Quinton, J.F., additional, Tiry, C., additional, Welty, S., additional, and Leroy, M.H., additional

Published
2002
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29. Outcomes of extremely premature infants admitted to a children's hospital depends on referring hospital.

Author

Shepherd, E. G., Calvert, T. J., Martin, E. M., Hitchner, J. C., Welty, S. E., and Nelin, L. D.

Subjects
PREMATURE infants, NEWBORN infants, NEONATAL intensive care, NEONATOLOGY
Abstract

Objective: The outcome of premature infants is negatively impacted by transport, and in Central Ohio every effort is made to transport the mother prior to preterm delivery. Our neonatal intensive care unit is an all referral unit, thus all babies are transported and the referral hospitals include those without neonatology coverage, and those with neonatology coverage. We tested the hypothesis that the outcomes of extremely premature infants (<27 weeks gestational age) admitted to our NICU would be better when the infant was referred from a hospital with neonatology coverage. Patients and methods: We collected data from 227 patients admitted from December, 2004 to August, 2008; 192 patients were from hospitals with neonatology coverage. Results: The survival rate was greater for those babies referred from hospitals with neonatology coverage than in those referred from hospitals without neonatology coverage (82% vs. 60%, p = 0.007), as was the combined outcome of survival without Grade 3/4 IVH (68% vs. 43%, p < 0.01). When limited to only those patients admitted at <3 days of life, survival was better for infants referred from hospitals with neonatology coverage than those referred from hospitals without it (77% vs. 63%; p < 0.05). Conclusion: These results suggest that for infants born at <27 weeks admitted to an all referral unit delivery in a hospital with neonatology coverage leads to better survival. [ABSTRACT FROM AUTHOR]

Published
2011
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32. Is there a role for antioxidant therapy in bronchopulmonary dysplasia?

Author

Welty, S E

Subjects
*THERAPEUTIC use of antioxidants, *BRONCHOPULMONARY dysplasia prevention, *PROTEIN metabolism, *BRONCHOPULMONARY dysplasia, *GENETIC disorders, *PREMATURE infants, *LIPID metabolism disorders, *OXIDATION-reduction reaction, *OXYGEN therapy, *OXIDATIVE stress, *THERAPEUTICS
Abstract

Bronchopulmonary dysplasia (BPD) is a chronic lung disease first described in 1967 as a complication of therapy for premature infants with hyaline membrane disease, and treatment with high concentrations of oxygen was thought to be a major contributor to its development. Thus, interventions to enhance lung antioxidants to prevent the development of BPD were considered appropriate therapeutic strategies. In the last decades, advances in the acute care of premature infants has reduced the reliance on therapy with high concentrations of supplemental oxygen. However, the incidence of BPD has not changed significantly. The changing clinical context in which BPD develops begs the question of whether oxidation is important in the development of BPD and, therefore, whether designing interventions enhancing lung antioxidants is still warranted. This review presents evidence that premature infants that will develop BPD have qualitative and quantitative differences in oxidation of lipids and proteins when compared to infants that do not develop BPD. Such differences in oxidation patterns are the most obvious in the first few days of life. The emerging evidence thus supports the concept that the lung injury process leading to the development of BPD occurs within hours to days of delivery and that oxidation is a major contributor to this pathological process. Unfortunately, early attempts at delivery of antioxidants to the lung have not been successful, perhaps because of an inability to deliver antioxidants in a timely manner to the areas in the lung in which deleterious oxidations are occurring. Further research is necessary to determine both the nature and the location of the oxidative events that lead to the development of early lung injury, so that more appropriate and specific antioxidant interventions can be designed. [ABSTRACT FROM AUTHOR]

Published
2001
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34. Potentiation of oxygen-induced lung injury in rats by the mechanism-based cytochrome P-450 inhibitor, 1-aminobenzotriazole.

Author

B, Moorthy, M, Parker K, V, Smith C, R, Bend J, and E, Welty S

Abstract

In this investigation, we tested the hypothesis that the cytochrome P-450 (CYP) inhibitor 1-aminobenzotriazole (ABT) alters the susceptibility of rats to hyperoxic lung injury. Male Sprague-Dawley rats were treated i.p. with ABT (66 mg/kg), i.v. with N-benzyl-1-aminobenzotriazole (1 micromol/kg), or the respective vehicles, followed by exposure to >95% oxygen for 24, 48, or 60 h. Pleural effusion volumes were measured as estimates of hyperoxic lung injury, and lung microsomal ethoxyresorufin O-deethylation (EROD) (CYP1A1) activities and CYP1A1 apoprotein levels were determined by Western blotting. ABT-pretreated animals exposed to hyperoxia died between 48 and 60 h, whereas no deaths were observed with up to 60 h of hyperoxia in vehicle-treated animals. In addition, three of four ABT-treated rats exposed to hyperoxia for 48 h showed marked pleural effusions. Exposure of vehicle-treated rats to hyperoxia led to 6.3-fold greater lung EROD activities and greater CYP1A1 apoprotein levels than in air-breathing controls after 48 h, but both declined to control levels by 60 h. Liver CYP1A1/1A2 enzymes displayed responses to hyperoxia and ABT similar to the effects on lung CYP1A1. N-Benzyl-1-aminobenzotriazole markedly inhibited lung microsomal pentoxyresorufin O-depentylation (principally CYP2B1) activities in air-breathing and hyperoxic animals but did not affect lung EROD or liver CYP activities. In conclusion, the results suggest that induction of CYP1A enzymes may serve as an adaptive response to hyperoxia, and that CYP2B1, the major pulmonary CYP isoform, does not contribute significantly to hyperoxic lung injury.

Published
2000

35. Selective modification of apoB-100 in the oxidation of low density lipoproteins by myeloperoxidase in vitro.

Author

Yang, C Y, Gu, Z W, Yang, M, Lin, S N, Garcia-Prats, A J, Rogers, L K, Welty, S E, and Smith, C V

Abstract

Oxidative modification of LDL may be important in the initiation and/or progression of atherosclerosis, but the precise mechanisms through which low density lipoprotein (LDL) is oxidized are unknown. Recently, evidence for the existence of HOCl-oxidized LDL in human atherosclerotic lesions has been reported, and myeloperoxidase (MPO), which is thought to act through production of HOCl, has been identified in human atherosclerotic lesions. In the present report we describe the formation of 2,4-dinitrophenylhydrazine (DNPH)-reactive modifications in the apolipoprotein (apo) by exposure of LDL to myeloperoxidase in vitro. In contrast with the complex mixture of peptides from oxidation of LDL with reagent HOCl, oxidation with MPO in vitro produced a major tryptic peptide showing absorbance at 365 nm. This peptide was isolated and characterized as VELEVPQL(*C)SFILK..., corresponding to amino acid residues 53-66...on apoB-100. Mass spectrometric analyses of two tryptic peptides from oxidation of LDL by HOCl indicated formation of the corresponding methionine sulfoxide (M=O), cysteinyl azo (*C), RS -N= N-DNP, derivatives of EEL(*C)T(M=O)FIR and LNDLNS VLV(M=O)PTFHVPFTDLQVPS(*C)K, which suggest oxidation to the corresponding sulfinic acids (RSO2H) by HOCl.The present results demonstrate that DNPH-reactive modifications other than aldehydes and ketones can be formed in the oxidation of proteins and illustrate how characterization of specific products of protein oxidation can be useful in assessing the relative contributions of different and unexpected mechanisms to the oxidation of LDL and other target substrates. The data also suggest a direct interaction of the LDL particle with the active site on myeloperoxidase and indicate that effects of the protein microenvironment can greatly influence product formation and stability.

Published
1999

36. Multiple mechanisms for oxygen-induced regulation of the Clara cell secretory protein gene.

Author

Ramsay, P. L., Luo, Z., Major, A., Park, M. S., Finegold, M., Welty, S. E., Kwak, I., Darlington, G., and Demayo, F. J.

Subjects
TRANSCRIPTION factors, PROTEINS, CELL physiology, DNA-protein interactions, GENE expression, GENETIC regulation
Abstract

The goal of the present study was to investigate the mechanisms of hyperoxia-induced repression of the mouse Clara cell secretory protein (CCSP) promoter. The first specific aim was to determine whether hyperoxia-induced repression of the CCSP gene is mediated at least in part at the level of transcription. The second specific aim was to identify the DNA-protein interactions that govern the transcriptional regulation of the CCSP gene during hyperoxia. [ABSTRACT FROM AUTHOR]

Published
2003
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47. Abstracts of the 26th World Congress on Ultrasound in Obstetrics and Gynecology, Rome, Italy, 24-28 September 2016.

Author

Britto, I.S., Sananes, N., Olutoye, O.O., Cass, D., Sangi-Haghpeykar, H., Cassady, C., Mehollin-Ray, A., Welty, S., Belfort, M., Lee, W., and Ruano, R.

Subjects
BLOOD vessels, DIAPHRAGMATIC hernia, TRACHEAL diseases
Abstract

An abstract of the article "Longitudinal ultrasound assessment of lung vasculature in fetuses with congenital diaphragmatic hernia treated by endoscopic tracheal occlusion and controls," by I. S. Britto and colleagues is presented.

Published
2016
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