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276 results on '"Weltje, Lennart"'

10. A Decision Logic for the Reliability Assessment and Interpretation of Vitellogenin Measurements.

Author

Brown, Rebecca J., Panter, Grace H., Burden, Natalie, Weltje, Lennart, Wheeler, James R., Salinas, Edward R., Wolf, Yvonne, and Lagadic, Laurent

Subjects
LITERATURE reviews, PROTEIN precursors, ENVIRONMENTAL chemistry, PESTICIDE pollution, FATHEAD minnow
Abstract

This article discusses the measurement and interpretation of vitellogenin (VTG) in fish and amphibians as a biomarker for endocrine activity. The reliability and acceptability of VTG results are important for regulatory assessments of chemicals. The article highlights the variability in VTG measurements and the need for improvement in sampling, quantification, and data handling. It proposes a decision logic to assist in the interpretation of VTG measurements and calls for the development of OECD guidance on best practices for VTG assessment. The article emphasizes the importance of considering other factors and endpoints in conjunction with VTG results to determine endocrine activity. [Extracted from the article]

Published
2024
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15. Optimizing the design of a reproduction toxicity test with the pond snail Lymnaea stagnalis

Author

Charles, Sandrine, Ducrot, Virginie, Azam, Didier, Benstead, Rachel, Brettschneider, Denise, De Schamphelaere, Karel, Filipe Goncalves, Sandra, Green, John W., Holbech, Henrik, Hutchinson, Thomas H., Faber, Daniel, Laranjeiro, Filipe, Matthiessen, Peter, Norrgren, Leif, Oehlmann, Jörg, Reategui-Zirena, Evelyn, Seeland-Fremer, Anne, Teigeler, Matthias, Thome, Jean-Pierre, Tobor Kaplon, Marysia, Weltje, Lennart, and Lagadic, Laurent

Published
2016
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19. Validation of the OECD reproduction test guideline with the New Zealand mudsnail Potamopyrgus antipodarum using trenbolone and prochloraz

Author

Geiß, Cornelia, Ruppert, Katharina, Askem, Clare, Barroso, Carlos, Faber, Daniel, Ducrot, Virginie, Holbech, Henrik, Hutchinson, Thomas H., Kajankari, Paula, Kinnberg, Karin Lund, Lagadic, Laurent, Matthiessen, Peter, Morris, Steve, Neiman, Maurine, Penttinen, Olli-Pekka, Sanchez-Marin, Paula, Teigeler, Matthias, Weltje, Lennart, and Oehlmann, Jörg

Published
2017
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20. Development and validation of an OECD reproductive toxicity test guideline with the pond snail Lymnaea stagnalis (Mollusca, Gastropoda)

Author

Ducrot, Virginie, Askem, Clare, Azam, Didier, Brettschneider, Denise, Brown, Rebecca, Charles, Sandrine, Coke, Maïra, Collinet, Marc, Delignette-Muller, Marie-Laure, Forfait-Dubuc, Carole, Holbech, Henrik, Hutchinson, Thomas, Jach, Arne, Kinnberg, Karin L., Lacoste, Cédric, Le Page, Gareth, Matthiessen, Peter, Oehlmann, Jörg, Rice, Lynsey, Roberts, Edward, Ruppert, Katharina, Davis, Jessica Elphinstone, Veauvy, Clemence, Weltje, Lennart, Wortham, Ruth, and Lagadic, Laurent

Published
2014
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27. Investigating endocrine‐disrupting properties of chemicals in fish and amphibians: Opportunities to apply the 3Rs

Author

Burden, Natalie, primary, Embry, Michelle R., additional, Hutchinson, Thomas H., additional, Lynn, Scott G., additional, Maynard, Samuel K., additional, Mitchell, Constance A., additional, Pellizzato, Francesca, additional, Sewell, Fiona, additional, Thorpe, Karen L., additional, Weltje, Lennart, additional, and Wheeler, James R., additional

Published
2021
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28. 16th SETAC GLB (Society of Environmental Toxicology and Chemistry German LanguageBranch) Annual meeting held under the main theme “EcoTOXICOlogy andEnvironmental CHEMISTRY: crossing borders” from 18th to 20th September2011 at Landau

Author

Brühl, Carsten A, Schäfer, Ralf B, Mittmann, Fabienne, Stahlschmidt, Peter, Bruns, Eric, Candolfi, Marco, Egeler, Philipp, Hollert, Henner, Kaiser, Dominic, Mohr, Silvia, Ratte, Toni, Schaumann, Gabriele E, Schlechtriem, Christian, Stock, Frauke, Scheebaum, Marco Vervliet, von der Ohe, Peter C, Weltje, Lennart, and Werner, Inge

Published
2012
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38. Investigating endocrine‐disrupting properties of chemicals in fish and amphibians: Opportunities to apply the 3Rs.

Author

Burden, Natalie, Embry, Michelle R., Hutchinson, Thomas H., Lynn, Scott G., Maynard, Samuel K., Mitchell, Constance A., Pellizzato, Francesca, Sewell, Fiona, Thorpe, Karen L., Weltje, Lennart, and Wheeler, James R.

Subjects
ENDOCRINE disruptors, CHEMICAL properties, ENVIRONMENTAL chemistry, ENVIRONMENTAL toxicology, ENVIRONMENTAL health
Abstract

Many regulations are beginning to explicitly require investigation of a chemical's endocrine‐disrupting properties as a part of the safety assessment process for substances already on or about to be placed on the market. Different jurisdictions are applying distinct approaches. However, all share a common theme requiring testing for endocrine activity and adverse effects, typically involving in vitro and in vivo assays on selected endocrine pathways. For ecotoxicological evaluation, in vivo assays can be performed across various animal species, including mammals, amphibians, and fish. Results indicating activity (i.e., that a test substance may interact with the endocrine system) from in vivo screens usually trigger further higher‐tier in vivo assays. Higher‐tier assays provide data on adverse effects on relevant endpoints over more extensive parts of the organism's life cycle. Both in vivo screening and higher‐tier assays are animal‐ and resource‐intensive and can be technically challenging to conduct. Testing large numbers of chemicals will inevitably result in the use of large numbers of animals, contradicting stipulations set out within many regulatory frameworks that animal studies be conducted as a last resort. Improved strategies are urgently required. In February 2020, the UK's National Centre for the 3Rs and the Health and Environmental Sciences Institute hosted a workshop ("Investigating Endocrine Disrupting Properties in Fish and Amphibians: Opportunities to Apply the 3Rs"). Over 50 delegates attended from North America and Europe, across academia, laboratories, and consultancies, regulatory agencies, and industry. Challenges and opportunities in applying refinement and reduction approaches within the current animal test guidelines were discussed, and utilization of replacement and/or new approach methodologies, including in silico, in vitro, and embryo models, was explored. Efforts and activities needed to enable application of 3Rs approaches in practice were also identified. This article provides an overview of the workshop discussions and sets priority areas for follow‐up. Integr Environ Assess Manag 2022;18:442–458. © 2021 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC). KEY POINTS: In vivo screening and higher‐tier assays to evaluate a chemical's potential endocrine‐disrupting properties and potential impacts on ecosystems are animal‐ and resource‐intensive and can be technically challenging to conduct.There has been much recent work to develop new approach methodologies (NAMs)—in silico and in vitro approaches—that can be applied in this space.An understanding of the opportunities and challenges with the current in vivo approaches, coupled with the ongoing efforts to expand the development, use, and application of NAMs, will help focus short‐ and long‐term goals.International, multisector science‐based activities provide the framework to improve ecological safety as it relates to compounds with endocrine‐disrupting properties. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Water and Sediment EQS Derivation and Application

Author

Matthiessen, Peter, primary, Babut, Marc, additional, Batley, Graeme, additional, Douglas, Mark, additional, Fawell, John, additional, Hommen, Udo, additional, Hutchinson, Thomas, additional, Janssen, Martien, additional, Maycock, Dawn, additional, Reiley, Mary, additional, Schneider, Uwe, additional, and Weltje, Lennart, additional

Published
2009
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46. Risk assessment of chemical mixtures in agricultural landscapes

Author

Holmes, Chris, Brown, Colin David, Hamer, Mick, Jones, Russell, Maltby, Lorraine, Silberhorn, Eric, Teeter, Jerold Scott, Warne, Michael, and Weltje, Lennart

Abstract

Environmental risk assessment of chemical mixtures is challenging because of the multitude of possible combinations that may occur. Aquatic risk from chemical mixtures in an agricultural landscape was evaluated prospectively in 2 exposure scenario case studies: at field scale for a program of 13 plant-protection products applied annually for 20 yr and at a watershed scale for a mixed land-use scenario over 30 yr with 12 plant-protection products and 2 veterinary pharmaceuticals used for beef cattle. Risk quotients were calculated from regulatory exposure models with typical real-world use patterns and regulatory acceptable concentrations for individual chemicals. The results could differentiate situations when there was concern associated with single chemicals from those when concern was associated with a mixture (based on concentration addition) with no single chemical triggering concern. Potential mixture risk was identified on 0.02 to 7.07% of the total days modeled, depending on the scenario, the taxa, and whether considering acute or chronic risk. Taxa at risk were influenced by receiving water body characteristics along with chemical use profiles and associated properties. The present study demonstrates that a scenario-based approach can be used to determine whether mixtures of chemicals pose risks over and above any identified using existing approaches for single chemicals, how often and to what magnitude, and ultimately which mixtures (and dominant chemicals) cause greatest concern.

Published
2018

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