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22 results on '"Welter, Nils"'

1. Diagnostic magnetic resonance imaging characteristics of congenital mesoblastic nephroma: a retrospective multi-center International Society of Pediatric Oncology-Renal Tumor Study Group (SIOP-RTSG) radiology panel study

Author

van der Beek, Justine N., Schenk, Jens-Peter, Morosi, Carlo, Watson, Tom A., Coma, Ana, Graf, Norbert, Chowdhury, Tanzina, Ramírez-Villar, Gema L., Spreafico, Filippo, Welter, Nils, Dzhuma, Kristina, van Tinteren, Harm, de Krijger, Ronald R., van den Heuvel-Eibrink, Marry M., and Littooij, Annemieke S.

Published
2024
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5. The impact of the route to diagnosis in nephroblastoma

Author

Mergen, Marvin, primary, Welter, Nils, additional, Furtwängler, Rhoikos, additional, Melchior, Patrick, additional, Vokuhl, Christian, additional, Gessler, Manfred, additional, Meier, Clemens‐Magnus, additional, Kager, Leo, additional, Schenk, Jens‐Peter, additional, and Graf, Norbert, additional

Published
2024
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6. How to improve initial diagnostic accuracy of kidney tumours in childhood?—A non‐invasive approach

Author

Welter, Nils, primary, Metternich, Gregor, additional, Furtwängler, Rhoikos, additional, Bayoumi, Ahmed, additional, Mergen, Marvin, additional, Kager, Leo, additional, Vokuhl, Christian, additional, Warmann, Steven W., additional, Fuchs, Jörg, additional, Meier, Clemens‐Magnus, additional, Melchior, Patrick, additional, Gessler, Manfred, additional, Wagenpfeil, Stefan, additional, Schenk, Jens‐Peter, additional, and Graf, Norbert, additional

Published
2024
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7. Diagnostic magnetic resonance imaging characteristics of congenital mesoblastic nephroma: a retrospective multi-center International Society of Pediatric Oncology-Renal Tumor Study Group (SIOP-RTSG) radiology panel study

Author

Cancer, Pathologie Pathologen staf, Zorg en O&O, Child Health, MS Radiologie, van der Beek, Justine N, Schenk, Jens-Peter, Morosi, Carlo, Watson, Tom A, Coma, Ana, Graf, Norbert, Chowdhury, Tanzina, Ramírez-Villar, Gema L, Spreafico, Filippo, Welter, Nils, Dzhuma, Kristina, van Tinteren, Harm, de Krijger, Ronald R, van den Heuvel-Eibrink, Marry M, Littooij, Annemieke S, Cancer, Pathologie Pathologen staf, Zorg en O&O, Child Health, MS Radiologie, van der Beek, Justine N, Schenk, Jens-Peter, Morosi, Carlo, Watson, Tom A, Coma, Ana, Graf, Norbert, Chowdhury, Tanzina, Ramírez-Villar, Gema L, Spreafico, Filippo, Welter, Nils, Dzhuma, Kristina, van Tinteren, Harm, de Krijger, Ronald R, van den Heuvel-Eibrink, Marry M, and Littooij, Annemieke S

Published
2024

9. The pathophysiology of bilateral and multifocal Wilms tumors: What we can learn from the study of predisposition syndromes

Author

Child Health, Cancer, Genetica Klinische Genetica, Welter, Nils, Brzezinski, Jack, Treece, Amy, Chintagumpala, Murali, Young, Matthew D, Perotti, Daniela, Kieran, Kathleen, Jongmans, Marjolijn C J, Murphy, Andrew J, Child Health, Cancer, Genetica Klinische Genetica, Welter, Nils, Brzezinski, Jack, Treece, Amy, Chintagumpala, Murali, Young, Matthew D, Perotti, Daniela, Kieran, Kathleen, Jongmans, Marjolijn C J, and Murphy, Andrew J

Published
2023

10. Impact of Time to Surgery on Outcome in Wilms Tumor Treated with Preoperative Chemotherapy

Author

Meier, Clemens-Magnus; https://orcid.org/0000-0001-5553-6302, Furtwängler, Rhoikos; https://orcid.org/0000-0002-1967-8343, Mergen, Marvin; https://orcid.org/0000-0002-3891-580X, Welter, Nils; https://orcid.org/0000-0001-9874-4726, Melchior, Patrick, Schenk, Jens-Peter, Vokuhl, Christian; https://orcid.org/0000-0002-4138-4536, Kager, Leo; https://orcid.org/0000-0003-4954-6488, Kroiss-Benninger, Sabine, Wagenpfeil, Stefan, Graf, Norbert; https://orcid.org/0000-0002-2248-323X, Meier, Clemens-Magnus; https://orcid.org/0000-0001-5553-6302, Furtwängler, Rhoikos; https://orcid.org/0000-0002-1967-8343, Mergen, Marvin; https://orcid.org/0000-0002-3891-580X, Welter, Nils; https://orcid.org/0000-0001-9874-4726, Melchior, Patrick, Schenk, Jens-Peter, Vokuhl, Christian; https://orcid.org/0000-0002-4138-4536, Kager, Leo; https://orcid.org/0000-0003-4954-6488, Kroiss-Benninger, Sabine, Wagenpfeil, Stefan, and Graf, Norbert; https://orcid.org/0000-0002-2248-323X

Abstract

(1) Background: Wilms tumor (WT) treated preoperatively is cured in over 90% of cases. However, how long preoperative chemotherapy can be given is unknown. (2) Methods: 2561/3030 patients with WT (age < 18 years) treated between 1989 and 2022 according to SIOP-9/GPOH, SIOP-93-01/GPOH, and SIOP-2001/GPOH are retrospectively analyzed to assess the risk of time to surgery (TTS) for relapse-free survival (RFS) and overall survival (OS). (3) Results: TTS was calculated for all surgeries, with the mean being 39 days (38.5 ± 12.5) for unilateral tumors (UWT) and 70 days (69.9 ± 32.7) for bilateral disease (BWT). Relapse occurred in 347 patients, of which 63 (2.5%) were local, 199 (7.8%) were metastatic, and 85 (3.3%) were combined. Moreover, 184 patients (7.2%) died, 152 (5.9%) due to tumor progression. In UWT, recurrences and mortality are independent of TTS. For BWT without metastases at diagnosis, the incidence of recurrence is less than 18% up to 120 days and increases to 29% after 120 days, and to 60% after 150 days. The risk of relapse (Hazard Ratio) adjusted for age, local stage, and histological risk group increases to 2.87 after 120 days (CI 1.19-7.95, p = 0.022) and to 4.62 after 150 days (CI 1.17-18.26, p = 0.029). In metastatic BWT, no influence of TTS is detected. (4) Conclusions: The length of preoperative chemotherapy has no negative impact on RFS or OS in UWT. In BWT without metastatic disease, surgery should be performed before day 120, as the risk of recurrence increases significantly thereafter.

Published
2023

13. Surgical Factors Influencing Local Relapse and Outcome in the Treatment of Unilateral Nephroblastoma

Author

Meier, Clemens Magnus, primary, Fuchs, Jörg, additional, von Schweinitz, Dietrich, additional, Stein, Raimund, additional, Wagenpfeil, Stefan, additional, Kager, Leo, additional, Schenk, Jens-Peter, additional, Vokuhl, Christian, additional, Melchior, Patrick, additional, Welter, Nils, additional, Furtwängler, Rhoikos, additional, and Graf, Norbert, additional

Published
2022
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14. Vena Cava Thrombus in Patients with Wilms Tumor

Author

Meier, Clemens-Magnus, primary, Furtwängler, Rhoikos, additional, von Schweinitz, Dietrich, additional, Stein, Raimund, additional, Welter, Nils, additional, Wagenpfeil, Stefan, additional, Kager, Leo, additional, Schenk, Jens-Peter, additional, Vokuhl, Christian, additional, Melchior, Patrick, additional, Fuchs, Jörg, additional, and Graf, Norbert, additional

Published
2022
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16. The variable clinical spectrum of nephroblastomatosis – results from the German Society of Pediatric Oncology and Hematology (GPOH) childhood kidney tumor group.

Author

Furtwängler, Rhoikos, primary, Schenk, Jens-Peter, additional, Friesenbichler, Waltraud, additional, Gessler, Manfred, additional, Wagenpfeil, Stefan, additional, Kager, Leo, additional, Müller, Marina, additional, Welter, Nils, additional, Fuchs, Jürgen, additional, Warmann, Steven, additional, Meier, Clemens M, additional, Hubertus, Jochen, additional, Rübe, Christian, additional, Vokuhl, Christian, additional, Melchior, Patrick, additional, and Graf, Norbert, additional

Published
2022
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18. Characteristics of Nephroblastoma/Nephroblastomatosis in Children with a Clinically Reported Underlying Malformation or Cancer Predisposition Syndrome

Author

Welter, Nils, primary, Wagner, Angelo, additional, Furtwängler, Rhoikos, additional, Melchior, Patrick, additional, Kager, Leo, additional, Vokuhl, Christian, additional, Schenk, Jens-Peter, additional, Meier, Clemens Magnus, additional, Siemer, Stefan, additional, Gessler, Manfred, additional, and Graf, Norbert, additional

Published
2021
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19. Characteristics of Nephroblastoma / Nephroblastomatosis in Children With a Clinically Reported Underlying Malformation or Cancer Predisposition Syndrome

Author

Welter, Nils, primary, Wagner, Angelo, additional, Furtwängler, Rhoikos, additional, Melchior, Patrick, additional, Kager, Leo, additional, Vokuhl, Christian, additional, Schenk, Jens-Peter, additional, Meier, Clemens Magnus, additional, Siemer, Stefan, additional, Gessler, Manfred, additional, and Graf, Norbert, additional

Published
2021
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20. Characteristics of nephroblastoma/nephroblastomatosis in children with a clinically reported underlying malformation or cancer predisposition syndrome

Author

Welter, Nils, Wagner, Angelo, Furtwängler, Rhoikos, Melchior, Patrick, Kager, Leo, Vokuhl, Christian, Schenk, Jens-Peter, Meier, Clemens Magnus, Siemer, Stefan, Gessler, Manfred, and Graf, Norbert

Subjects
nephroblastoma, cancer predisposition syndromes, outcome, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Correction, clinical malformations, ddc:610, Article, tumor surveillance, RC254-282
Abstract

Simple Summary It is well known that different cancer predisposition syndromes are associated with characteristic WT-features. The following findings from our retrospective analysis of patients with nephroblastoma treated according to the SIOP/GPOH trials between 1989 and 2017 are relevant: (1) The outcome of patients with a cancer predisposition syndrome is not always favorable despite early diagnosis, small tumors and less metastatic disease. This finding is partly depending on complications related to the underlying syndrome. (2) Predisposition syndromes seem to be underdiagnosed as several clinical and pathological features of Wilms tumor being clearly linked to a cancer predisposition syndrome did not lead to genetic counseling before and after WT diagnosis. As a conclusion, in children with a nephroblastoma and specific clinical and pathological features that are in line with a nephroblastoma cancer predisposition syndrome such a syndrome should always be considered and ruled out if unknown at the time of tumor diagnosis. Abstract (1) Background: about 10% of Wilms Tumor (WT) patients have a malformation or cancer predisposition syndrome (CPS) with causative germline genetic or epigenetic variants. Knowledge on CPS is essential for genetic counselling. (2) Methods: this retrospective analysis focused on 2927 consecutive patients with WTs registered between 1989 and 2017 in the SIOP/GPOH studies. (3) Results: Genitourinary malformations (GU, N = 66, 2.3%), Beckwith-Wiedemann spectrum (BWS, N = 32, 1.1%), isolated hemihypertrophy (IHH, N = 29, 1.0%), Denys-Drash syndrome (DDS, N = 24, 0.8%) and WAGR syndrome (N = 20, 0.7%) were reported most frequently. Compared to others, these patients were younger at WT diagnosis (median age 24.5 months vs. 39.0 months), had smaller tumors (349.4 mL vs. 487.5 mL), less often metastasis (8.2% vs. 18%), but more often nephroblastomatosis (12.9% vs. 1.9%). WT with IHH was associated with blastemal WT and DDS with stromal subtype. Bilateral WTs were common in WAGR (30%), DDS (29%) and BWS (31%). Chemotherapy induced reduction in tumor volume was poor in DDS (0.4% increase) and favorable in BWS (86.9% reduction). The event-free survival (EFS) of patients with BWS was significantly (p = 0.002) worse than in others. (4) Conclusions: CPS should be considered in WTs with specific clinical features resulting in referral to a geneticist. Their outcome was not always favorable.

Published
2021

21. Correction: Welter et al. Characteristics of Nephroblastoma/Nephroblastomatosis in Children with a Clinically Reported Underlying Malformation or Cancer Predisposition Syndrome. Cancers 2021, 13 , 5016.

Author

Welter, Nils, Wagner, Angelo, Furtwängler, Rhoikos, Melchior, Patrick, Kager, Leo, Vokuhl, Christian, Schenk, Jens-Peter, Meier, Clemens Magnus, Siemer, Stefan, Gessler, Manfred, and Graf, Norbert

Subjects
*NEPHROBLASTOMA, *DISEASE susceptibility, *SYMPTOMS, *CHILDREN
Published
2021
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22. Neue Freiheiten.

Author

Sander, Christoph, Schneider, Andre, and Welter, Nils

Abstract

Copyright of Fernseh und Kino-Technik is the property of Fachverlag Schiele und Schoen GmbH and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2014

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