1. Pediatric pineoblastoma: A pooled outcome study of North American and Australian therapeutic data
- Author
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Hansford, Jordan R, Huang, Jie, Endersby, Raelene, Dodgshun, Andrew J, Li, Bryan K, Hwang, Eugene, Leary, Sarah, Gajjar, Amar, Von Hoff, Katja, Wells, Olivia, Wray, Alison, Kotecha, Rishi S, Raleigh, David R, Stoller, Schuyler, Mueller, Sabine, Schild, Steven E, Bandopadhayay, Pratiti, Fouladi, Maryam, Bouffet, Eric, Huang, Annie, Onar-Thomas, Arzu, and Gottardo, Nicholas G
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Cancer ,Clinical Research ,Pediatric ,Clinical Trials and Supportive Activities ,Good Health and Well Being ,pediatrics ,pineoblastoma ,retrospective study - Abstract
BackgroundPineoblastoma is a rare brain tumor usually diagnosed in children. Given its rarity, no pineoblastoma-specific trials have been conducted. Studies have included pineoblastoma accruing for other embryonal tumors over the past 30 years. These included only occasional children with pineoblastoma, making clinical features difficult to interpret and determinants of outcome difficult to ascertain.Patients and methodsCentrally or independently reviewed series with treatment and survival data from North American and Australian cases were pooled. To investigate associations between variables, Fisher's exact tests, Wilcoxon-Mann-Whitney tests, and Spearman correlations were used. Kaplan-Meier plots, log-rank tests, and Cox proportional hazards models were used in survival analyses.ResultsWe describe a pooled cohort of 178 pineoblastoma cases from Children's Oncology Group (n = 82) and institutional series (n = 96) over 30 years. Children
- Published
- 2022