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31 results on '"Wells, F. R."'

13. The Site of Vascular Response to the α-Toxin of Clostridium Perfringens Type A in Skeletal Muscle

Author

Wells, F. R.

Subjects
Male, Time Factors, Clostridium perfringens, Muscles, Articles, Carbon, Capillaries, Rats, Veins, Capillary Permeability, Microscopy, Electron, Animals, Coloring Agents, Toxins, Biological
Abstract

The vascular response to the α-toxin of Clostridium perfringens type A, was observed topographically in the cremaster muscle of the rat, in terms of exudation, labelling of damaged vessels by circulating carbon, and in addition histologically for patency of the vascular plexus.

Published
1972

14. Site of Vascular Response to Thermal Injury in Skeletal Muscle

Author

Wells, F. R.

Subjects
Male, Cell Membrane Permeability, Hot Temperature, Time Factors, Muscles, Sodium Salicylate, Articles, Blood Proteins, Exudates and Transudates, Anesthesia, General, Carbon, Capillaries, Rats, Veins, Capillary Permeability, Microscopy, Electron, Scrotum, Animals, Blood Vessels, Burns, Skin
Abstract

The vascular response to mild thermal injury—54° for 20 and 40 sec.—was observed topographically in the cremaster muscle of the rat, in terms of exudation, labelling of damaged vessels by carbon particles in the circulation, and patency of the vascular plexus.

Published
1971

15. A Comparison of the Cellular and Vascular Responses in Delayed Hypersensitivity to Tuberculin, of Rat and Guinea-Pig Dorsal Skin

Author

Wells, F. R.

Subjects
Male, Carbon Isotopes, Time Factors, Staining and Labeling, Guinea Pigs, Proteins, Articles, Exudates and Transudates, Tuberculin, Capillaries, Rats, Capillary Permeability, Cell Movement, Leukocytes, Animals, Blood Vessels, Female, Hypersensitivity, Delayed, Skin
Abstract

The vascular response in tuberculin hypersensitized rats and guinea-pigs, each bearing lesions of one age only, was measured in the rats in terms of migration of leucocytes and in both species, in terms of exudation of protein and labelling of the affected vessels by circulating carbon.

Published
1972

20. Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: an HPLC and ESR study.

Author

Dexter DT, Holley AE, Flitter WD, Slater TF, Wells FR, Daniel SE, Lees AJ, Jenner P, and Marsden CD

Subjects
Chromatography, High Pressure Liquid, Electron Spin Resonance Spectroscopy, Female, Free Radicals, Humans, Male, Nerve Degeneration physiology, Lipid Peroxidation physiology, Lipid Peroxides analysis, Parkinson Disease pathology, Substantia Nigra pathology
Abstract

Previous studies examining the involvement of oxidative stress in the substantia nigra in Parkinson's disease have measured terminal products of lipid peroxidation or the function of antioxidant defense systems. We report a more specific early marker of lipid peroxidation, lipid hydroperoxides, in a high-performance liquid chromatography (HPLC) and electron spin resonance (ESR) investigation. HPLC-chemiluminescent detection revealed two classes of lipid hydroperoxides in brain tissue extracts--free fatty acid hydroperoxides and cholesterol lipid hydroperoxides. Only cholesterol lipid hydroperoxides were consistently detected in all tissue extracts. Cholesterol lipid hydroperoxides had a 10-fold increase in the Parkinson's disease substantia nigra compared to control subjects. ESR detection of radical degradation products, including those of lipid hydroperoxides, in nigral homogenates incubated with the spin trap N-t-butyl-alpha-phenyl nitrone (PBN) showed a marked variation in ESR signal between tissues. Despite the increased levels of lipid hydroperoxides in parkinsonian substantia nigra, there was no overall difference in ESR signal intensity between nigral tissues from controls and from patients with Parkinson's disease. The increased levels of an early component of the peroxidation chain in substantia nigra in Parkinson's disease support the hypothesis of a continuous toxic process involving oxygen radical activity. However, using previously frozen tissue, ESR evidence for increased radical formation could not be demonstrated.

Published
1994
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21. Alpha-tocopherol levels in brain are not altered in Parkinson's disease.

Author

Dexter DT, Ward RJ, Wells FR, Daniel SE, Lees AJ, Peters TJ, Jenner P, and Marsden CD

Subjects
Aged, Cerebellum chemistry, Female, Humans, Lipids analysis, Male, Reference Values, Brain Chemistry, Parkinson Disease metabolism, Vitamin E analysis
Abstract

alpha-Tocopherol (vitamin E) levels in normal brain were lower in the cerebellum than in the cerebral cortex or basal ganglia. There was no difference in alpha-tocopherol levels in the cerebellum, basal ganglia, or cerebral cortex between control subjects and patients with Parkinson's disease.

Published
1992
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22. Pathology of MPTP in the marmoset.

Author

Gibb WR, Lees AJ, Wells FR, Barnard RO, Jenner P, and Marsden CD

Subjects
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Callitrichinae, Catecholamines metabolism, Dose-Response Relationship, Drug, Female, Male, Neurons drug effects, Substantia Nigra drug effects, Brain drug effects, Parkinson Disease, Secondary chemically induced, Pyridines toxicity
Published
1987

28. Carbon labeling of injured microvessels--relation to vascular permeability and microvascular patency.

Author

Wells FR

Subjects
Animals, Basement Membrane pathology, Bradykinin pharmacology, Carbon metabolism, Endothelium drug effects, Endothelium pathology, Histamine pharmacology, Microcirculation drug effects, Microscopy, Electron, Muscles blood supply, Phospholipases pharmacology, Rats, Serotonin pharmacology, Veins drug effects, Veins pathology, Capillary Permeability drug effects, Microcirculation pathology
Published
1973

30. The site of vascular response to thermal injury in skeletal muscle.

Author

Wells FR

Subjects
Anesthesia, General, Animals, Blood Proteins, Blood Vessels injuries, Burns drug therapy, Capillaries physiopathology, Capillary Permeability, Carbon administration & dosage, Cell Membrane Permeability, Exudates and Transudates, Male, Microscopy, Electron, Rats, Scrotum, Sodium Salicylate therapeutic use, Time Factors, Veins physiopathology, Burns physiopathology, Hot Temperature, Muscles blood supply, Muscles injuries, Skin blood supply
Published
1971

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