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1. Early Warning Surveillance for SARS-CoV-2 Omicron Variants, United Kingdom, November 2021--September 2022

Author

Foulkes, Sarah, Monk, Edward J.M., Sparkes, Dominic, Hettiarachchi, Nipunadi, Milligan, Iain D., Munro, Katie, Taylor- Kerr, Andrew, Platt, Naomi, Howells, Anna, Kyaw, Jerry Ye Aung, Adaji, Enemona, Gallagher, Eileen, Khawam, Jameel, Wellington, Edgar, Price, Lesley, Crossman, David, Norman, Chris, de Lacy, Elen, Cromey, Lisa, Corrigan, Diane, Lackenby, Angie, Barbero, Paola, Elegunde, Busayo, Zambon, Maria, Chand, Meera A., Brown, Colin S., Islam, Jasmin, Atti, Ana, Hopkins, Susan, Hall, Victoria J., and Cole, Michelle J.

Subjects
Epidemics -- Causes of -- Statistics -- United Kingdom, Sentinel health events -- Methods, Medical personnel -- Statistics -- Health aspects, Health
Abstract

Since June 2020, the SARS-CoV-2 Immunity and Reinfection Evaluation (SIREN) Study has detected and investigated SARS-CoV-2 reinfections in the United Kingdom; after vaccine rollout, SIREN was adapted to monitor vaccine [...]

Published
2023
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2. T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study

Author

Harding, Adam, Watson, Adam, Shields, Adrian, Angyal, Adrienn, Alhussni, Ahmed, Richter, Alex, Nicols, Alexander, Deeks, Alexandra, Webb-Bridges, Alice, Cross, Andrew, Ogbe, Ane, Jämsén, Anni, Brown, Anthony, Chawla, Anu, Dold, Christina, Duncan, Christopher, Conlon, Christopher, Skelly, Donal, O'Donnell, Denise, Barnes, Eleanor, Adland, Emily, Weeks, Esme, Sandhar, Gurjinder, Hornsby, Hailey, Brown, Helen, Mehta, Hema, Abuelgasim, Hibatullah, Xiao, Huiyuan, Austin, James, Spegarova, Jarmila, Holmes, Jennifer, Haworth, Jenny, Tyerman, Jessica, Frater, John, Kilby, Jonathan, Cutteridge, Joseph, Jeffery, Katie, Lillie, Katy, Turtle, Lance, Romaniuk, Leigh, Denly, Lucy, Hering, Luisa, Ansari, M. Azim, Pace, Matthew, Chand, Meera, Carroll, Miles, Ali, Mohammad, Kasanyinga, Mwila, Meardon, Naomi, Gillson, Natalie, Rongkard, Patpong, Klenerman, Paul, Goulder, Philip, Matthews, Philippa, Whitham, Rachel, Brown, Rebecca, Payne, Rebecca, Wilson, Robert, Rowland-Jones, Sarah, Thomas, Sarah, Moore, Shona, Gardiner, Siobhan, Longet, Stephanie, Tucker, Stephanie, Dobson, Sue, Hopkins, Susan, Dunachie, Susanna, Adlou, Syed, de Silva, Thushan, Tipton, Tom, Hall, Victoria, James, William, Lawrie, Allan, Smith, Nikki, Turton, Helena, Zawia, Amira, Bayley, Martin, Fairman, Alex, Harrington, Kate, Kirk, Rosemary, Marsh, Louise, Watson, Lisa, Wood, Steven, Diffey, Benjamin, Jones, Chris, Lett, Lauren, Platt, Gareth, Subramaniam, Krishanthi, Wootton, Daniel, Payne, Brendan, Hambleton, Sophie, Kelly, Sinead, Marston, Judith, Poolan, Sonia, Turner, Dianne, Haniffa, Muzlifah, Stephenson, Emily, Adele, Sandra, Akhter, Hossain Delowar, Chinnakannan, Senthil, de Lara, Catherine, Donnison, Timothy, Hackstein, Carl-Philipp, Lee, Lian, Lim, Nicholas, Malone, Tom, Phillips, Eloise, Ramamurthy, Narayan, Robinson, Nichola, Sampson, Oliver, Eyre, David, Simmons, Beatrice, Stafford, Lizzie, Mentzer, Alexander, Amini, Ali, Arancibia-Cárcamo, Carolina, Provine, Nicholas, Travis, Simon, Dimitriadis, Stavros, Johnson, Sile, Foulkes, Sarah, Khawam, Jameel, Wellington, Edgar, Gilbert-Jaramillo, Javier, Knight, Michael, Dupont, Maeva, Horner, Emily, Thaventhiran, James, Chalk, Jeremy, Moore, Shona C, Payne, Rebecca P, Hering, Luisa M, Dobson, Sue L, Kilby, Jonathan A, Tyerman, Jessica K, Nicols, Alexander R, Spegarova, Jarmila S, Conlon, Christopher P, Ansari, M Azim, Matthews, Philippa C, Rowland-Jones, Sarah L, Duncan, Christopher J A, and de Silva, Thushan I

Published
2022
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3. COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study

Author

Andrews, N, Atti, A, Aziz, H, Brooks, T, Brown, CS, Camero, D, Carr, C, Chand, MA, Charlett, A, Crawford, H, Cole, M, Conneely, J, D'Arcangelo, S, Ellis, J, Evans, S, Foulkes, S, Gillson, N, Gopal, R, Hall, L, Hall, VJ, Harrington, P, Hopkins, S, Hewson, J, Hoschler, K, Ironmonger, D, Islam, J, Kall, M, Karagiannis, I, Kay, O, Khawam, J, King, E, Kirwan, P, Kyffin, R, Lackenby, A, Lattimore, M, Linley, E, Lopez-Bernal, J, Mabey, L, McGregor, R, Miah, S, Monk, EJM, Munro, K, Naheed, Z, Nissr, A, O'Connell, AM, Oguti, B, Okafor, H, Organ, S, Osbourne, J, Otter, A, Patel, M, Platt, S, Pople, D, Potts, K, Ramsay, M, Robotham, J, Rokadiya, S, Rowe, C, Saei, A, Sebbage, G, Semper, A, Shrotri, M, Simmons, R, Soriano, A, Staves, P, Taylor, S, Taylor, A, Tengbe, A, Tonge, S, Vusirikala, A, Wallace, S, Wellington, E, Zambon, M, Corrigan, D, Sartaj, M, Cromey, L, Campbell, S, Braithwaite, K, Price, L, Haahr, L, Stewart, S, Lacey, ED, Partridge, L, Stevens, G, Ellis, Y, Hodgson, H, Norman, C, Larru, B, Mcwilliam, S, Roynon, A, Northfield, J, Winchester, S, Cieciwa, P, Pai, A, Bakker, P, Loughrey, C, Watt, A, Adair, F, Hawkins, A, Grant, A, Temple-Purcell, R, Howard, J, Slawson, N, Subudhi, C, Davies, S, Bexley, A, Penn, R, Wong, N, Boyd, G, Rajgopal, A, Arenas-Pinto, A, Matthews, R, Whileman, A, Laugharne, R, Ledger, J, Barnes, T, Jones, C, Osuji, N, Chitalia, N, Bailey, T, Akhtar, S, Harrison, G, Horne, S, Walker, N, Agwuh, K, Maxwell, V, Graves, J, Williams, S, O'Kelly, A, Ridley, P, Cowley, A, Johnstone, H, Swift, P, Democratis, J, Meda, M, Brake, S, Gunn, J, Selassi, A, Hams, S, Irvine, V, Chandrasekaran, B, Forsyth, C, Radmore, J, Thomas, C, Brown, K, Roberts, S, Burns, P, Gajee, K, Lewis, T, Byrne, TM, Sanderson, F, Knight, S, Macnaughton, E, Burton, BJL, Smith, H, Chaudhuri, R, Aeron-Thomas, J, Hollinshead, K, Shorten, RJ, Swan, A, Favager, C, Murira, J, Baillon, S, Hamer, S, Shah, A, Russell, J, Brennan, D, Dave, A, Chawla, A, Westwell, F, Adeboyeku, D, Papineni, P, Pegg, C, Williams, M, Ahmad, S, Horsley, A, Gabriel, C, Pagget, K, Maloney, G, Ashcroft, J, Del Rosario, I, Crosby-Nwaobi, R, Flanagan, D, Dhasmana, D, Fowler, S, Cameron, E, Prentice, L, Sinclair, C, Bateman, V, McLelland-Brooks, K, Ho, A, Murphy, M, Cochrane, A, Gibson, A, Black, K, Tempeton, K, Donaldson, S, Coke, L, Elumogo, N, Elliott, J, Padgett, D, Cross, A, Mirfenderesky, M, Joyce, S, Sinanovic, I, Howard, M, Cowling, P, Brazil, M, Hanna, E, Abdelrazik, A, Brand, S, Sheridan, EA, Wadams, B, Lloyd, A, Mouland, J, Giles, J, Pottinger, G, Coles, H, Joseph, M, Lee, M, Orr, S, Chenoweth, H, Browne, D, Auckland, C, Lear, R, Mahungu, T, Rodger, A, Warren, S, Brooking, D, Pai, S, Druyeh, R, Smith, E, Stone, S, Meisner, S, Delgado, D, Underhill, E, Keen, L, Aga, M, Domingos, P, Gormley, S, Kerrison, C, Birch, S, DeSilva, T, Allsop, L, Ambalkar, S, Beekes, M, Jose, S, Tomlinson, J, Painter, Sharen, Price, C, Pepperell, J, James, K, Trinick, T, Moore, L, Day, J, Boulos, A, Knox, I, Defever, E, McCracken, D, Gray, K, Houston, A, Planche, T, Pritchard Jones, R, Wycherley, Diane, Bennett, S, Marrs, J, Nimako, K, Stewart, B, Bain, SC, Kalakonda, N, Khanduri, S, Ashby, A, Holden, M, Mahabir, N, Harwood, J, Payne, B, Court, K, White, N, Longfellow, R, Hughes, LE, Green, ME, Halkes, M, Mercer, P, Roebuck, A, Wilson-Davies, E, Gallego, L, Lazarus, R, Aldridge, N, Berry, L, Game, F, Reynolds, T, Holmes, C, Wiselka, M, Higham, A, Booth, M, Duff, C, Alderton, J, Hilton, D, Powell, J, Jackson, A, Plant, AJ, Ahmed, N, Chin, T, Qazzafi, MZ, Moody, AM, Tilley, RE, Donaghy, T, O'Kane, M, Shipman, K, Sierra, R, Parmar, C, Mills, G, Harvey, D, Huang, YWJ, Birch, J, Robinson, L, Board, S, Broadley, A, Laven, C, Todd, N, Eyre, DW, Jeffery, K, Dunachie, S, Duncan, C, Klenerman, P, Turtle, L, Baxendale, H, Heeney, JL, Hall, Victoria Jane, Foulkes, Sarah, Saei, Ayoub, Andrews, Nick, Oguti, Blanche, Charlett, Andre, Wellington, Edgar, Stowe, Julia, Gillson, Natalie, Atti, Ana, Islam, Jasmin, Karagiannis, Ioannis, Munro, Katie, Khawam, Jameel, Chand, Meera A, Brown, Colin S, Ramsay, Mary, Lopez-Bernal, Jamie, and Hopkins, Susan

Published
2021
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4. SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN)

Author

Andrews, N, Atti, A, Aziz, H, Brooks, T, Brown, CS, Camero, D, Carr, C, Chand, MA, Charlett, A, Crawford, H, Cole, M, Conneely, J, D'Arcangelo, S, Ellis, J, Evans, S, Foulkes, S, Gillson, N, Gopal, R, Hall, L, Hall, VJ, Harrington, P, Hopkins, S, Hewson, J, Hoschler, K, Ironmonger, D, Islam, J, Kall, M, Karagiannis, I, Kay, O, Khawam, J, King, E, Kirwan, P, Kyffin, R, Lackenby, A, Lattimore, M, Linley, E, Lopez-Bernal, J, Mabey, L, McGregor, R, Miah, S, Monk, EJM, Munro, K, Naheed, Z, Nissr, A, O'Connell, AM, Oguti, B, Okafor, H, Organ, S, Osbourne, J, Otter, A, Patel, M, Platt, S, Pople, D, Potts, K, Ramsay, M, Robotham, J, Rokadiya, S, Rowe, C, Saei, A, Sebbage, G, Semper, A, Shrotri, M, Simmons, R, Soriano, A, Staves, P, Taylor, S, Taylor, A, Tengbe, A, Tonge, S, Vusirikala, A, Wallace, S, Wellington, E, Zambon, M, Corrigan, D, Sartaj, M, Cromey, L, Campbell, S, Braithwaite, K, Price, L, Haahr, L, Stewart, S, Lacey, ED, Partridge, L, Stevens, G, Ellis, Y, Hodgson, H, Norman, C, Larru, B, Mcwilliam, S, Winchester, S, Cieciwa, P, Pai, A, Loughrey, C, Watt, A, Adair, F, Hawkins, A, Grant, A, Temple-Purcell, R, Howard, J, Slawson, N, Subudhi, C, Davies, S, Bexley, A, Penn, R, Wong, N, Boyd, G, Rajgopal, A, Arenas-Pinto, A, Matthews, R, Whileman, A, Laugharne, R, Ledger, J, Barnes, T, Jones, C, Botes, D, Chitalia, N, Akhtar, S, Harrison, G, Horne, S, Walker, N, Agwuh, K, Maxwell, V, Graves, J, Williams, S, O'Kelly, A, Ridley, P, Cowley, A, Johnstone, H, Swift, P, Democratis, J, Meda, M, Callens, C, Beazer, S, Hams, S, Irvine, V, Chandrasekaran, B, Forsyth, C, Radmore, J, Thomas, C, Brown, K, Roberts, S, Burns, P, Gajee, K, Byrne, TM, Sanderson, F, Knight, S, Macnaughton, E, Burton, BJL, Smith, H, Chaudhuri, R, Hollinshead, K, Shorten, RJ, Swan, A, Favager, C, Murira, J, Baillon, S, Hamer, S, Gantert, K, Russell, J, Brennan, D, Dave, A, Chawla, A, Westell, F, Adeboyeku, D, Papineni, P, Pegg, C, Williams, M, Ahmad, S, Ingram, S, Gabriel, C, Pagget, K, Maloney, G, Ashcroft, J, Del Rosario, I, Crosby-Nwaobi, R, Reeks, C, Fowler, S, Prentice, L, Spears, M, McKerron, G, McLelland-Brooks, K, Anderson, J, Donaldson, S, Templeton, K, Coke, L, Elumogo, N, Elliott, J, Padgett, D, Mirfenderesky, M, Cross, A, Price, J, Joyce, S, Sinanovic, I, Howard, M, Lewis, T, Cowling, P, Potoczna, D, Brand, S, Sheridan, L, Wadams, B, Lloyd, A, Mouland, J, Giles, J, Pottinger, G, Coles, H, Joseph, M, Lee, M, Orr, S, Chenoweth, H, Auckland, C, Lear, R, Mahungu, T, Rodger, A, Penny-Thomas, K, Pai, S, Zamikula, J, Smith, E, Stone, S, Boldock, E, Howcroft, D, Thompson, C, Aga, M, Domingos, P, Gormley, S, Kerrison, C, Marsh, L, Tazzyman, S, Allsop, L, Ambalkar, S, Beekes, M, Jose, S, Tomlinson, J, Jones, A, Price, C, Pepperell, J, Schultz, M, Day, J, Boulos, A, Defever, E, McCracken, D, Gray, K, Houston, A, Planche, T, Pritchard Jones, R, Wycherley, Diane, Bennett, S, Marrs, J, Nimako, K, Stewart, B, Kalakonda, N, Khanduri, S, Ashby, A, Holden, M, Mahabir, N, Harwood, J, Payne, B, Court, K, Staines, N, Longfellow, R, Green, ME, Hughes, LE, Halkes, M, Mercer, P, Roebuck, A, Wilson-Davies, E, Gallego, L, Lazarus, R, Aldridge, N, Berry, L, Game, F, Reynolds, T, Holmes, C, Wiselka, M, Higham, A, Booth, M, Duff, C, Alderton, J, Jory, H, Virgilio, E, Chin, T, Qazzafi, MZ, Moody, AM, Tilley, R, Donaghy, T, Shipman, K, Sierra, R, Jones, N, Mills, G, Harvey, D, Huang, YWJ, Birch, J, Robinson, L, Board, S, Broadley, A, Laven, C, Todd, N, Eyre, DW, Jeffery, K, Dunachie, S, Duncan, C, Klenerman, P, Turtle, L, De Silva, T, Baxendale, H, Heeney, JL, Hall, Victoria Jane, Foulkes, Sarah, Charlett, Andre, Atti, Ana, Monk, Edward J M, Simmons, Ruth, Wellington, Edgar, Cole, Michelle J, Saei, Ayoub, Oguti, Blanche, Munro, Katie, Wallace, Sarah, Kirwan, Peter D, Shrotri, Madhumita, Vusirikala, Amoolya, Rokadiya, Sakib, Kall, Meaghan, Zambon, Maria, Ramsay, Mary, Brooks, Tim, Brown, Colin S, Chand, Meera A, and Hopkins, Susan

Published
2021
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5. Do Antibody Positive Healthcare Workers Have Lower SARS-CoV-2 Infection Rates than Antibody Negative Healthcare Workers? Large Multi-Centre Prospective Cohort Study (The SIREN Study), England: June to November 2020

Author

Hall, Victoria Jane, Foulkes, Sarah, Charlett, Andre, Atti, Ana, Monk, Edward JM, Simmons, Ruth, Wellington, Edgar, Cole, Michelle, Saei, Ayoub, Oguti, Blanche, Munro, Katie, Wallace, S, Kirwan, Peter, Shrotri, Madhumita, Vusirikala, Amoolya, Rokadiya, Sakib, Kall, Meaghan, Zambon, Maria, Ramsay, Mary, Brooks, T, Group, SIREN Study, Brown, Colin, Chand, Meera, Hopkins, Susan, Shrotri, Madhumita [0000-0001-9791-122X], Hopkins, Susan [0000-0001-5179-5702], and Apollo - University of Cambridge Repository

Abstract

Background: There is an urgent need to better understand whether individuals who have recovered from COVID-19 are protected from future SARS-CoV-2 infection.Methods: A large multi-centre prospective cohort was recruited from publicly funded hospital staff in the UK. Participants attended regular SARS-CoV-2 PCR and antibody testing (every 2-4 weeks) and completed fortnightly questionnaires on symptoms and exposures. At enrolment, participants were assigned to either the positive cohort (antibody positive or prior PCR/antibody test positive) or negative cohort (antibody negative, not previously known to be PCR/antibody positive). Potential reinfections were clinically reviewed and classified according to case definitions (confirmed, probable, possible (subdivided by symptom-status)) depending on hierarchy of evidence. Individuals in the primary infection were excluded from this analysis if infection was confirmed by antibody only. Reinfection rates in the positive cohort were compared against new PCR positives in the negative cohort using a mixed effective multivariable logistic regression analysis.Findings: Between 18 June and 09 November 2020, 44 reinfections (2 probable, 42 possible) were detected in the baseline positive cohort of 6,614 participants, collectively contributing 1,339,078 days of follow-up. This compares with 318 new PCR positive infections and 94 antibody seroconversions in the negative cohort of 14,173 participants, contributing 1,868,646 days of follow-up. The incidence density per 100,000 person days between June and November 2020 was 3.2 reinfections in the positive cohort, compared with 22.4 new PCR confirmed infections in the negative cohort. The adjusted odds ratio was 0.17 for all reinfections (95% CI 0.13-0.24) compared to PCR confirmed primary infections. The median interval between primary infection and reinfection was over 160 days.Interpretation: A prior history of SARS-CoV-2 infection was associated with an 83% lower risk of infection, with median protective effect observed five months following primary infection. This is the minimum likely effect as seroconversions were not included.Trial Registration: Trial registered with ISRCTN, Trial ID: ISRCTN11041050. https://www.isrctn.com/ISRCTN11041050.Funding Statement: Department of Health and Social Care and Public Health England, with contributions from the Scottish, Welsh and Northern Irish governments.Declaration of Interests: No conflicts of interest declared.Ethics Approval Statement: IRAS ID 284460, Berkshire Research Ethics Committee, Health Research Authority and Health and Care Research Wales approval granted 22 May 2020.

Published
2022
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6. Burden of SARS-CoV-2 infection in healthcare workers during second wave in England and impact of vaccines : prospective multicentre cohort study (SIREN) and mathematical model

Author

Pople, Diane, Monk, Edward J M, Evans, Stephanie, Foulkes, Sarah, Islam, Jasmin, Wellington, Edgar, Atti, Ana, Hope, Russell, Robotham, Julie, Hopkins, Susan, Brown, Colin S, Hall, Victoria J, SIREN Study Group, Dhasmana, Devesh J, and University of St Andrews. School of Medicine

Subjects
Adult, Models, theoretical, Vaccines, COVID-19 Vaccines, SARS-CoV-2, Health Personnel, COVID-19, COVID-19 vaccines, General Medicine, 3rd-DAS, Models, Theoretical, Health personnel, State Medicine, SDG 3 - Good Health and Well-being, RA0421, RA0421 Public health. Hygiene. Preventive Medicine, Communicable Disease Control, Humans, Prospective Studies, Pandemics/prevention & control, Pandemics, Prospective studies, COVID-19/epidemiology
Abstract

ObjectiveTo describe the incidence of, risk factors for, and impact of vaccines on primary SARS-CoV-2 infection during the second wave of the covid-19 pandemic in susceptible hospital healthcare workers in England.DesignMulticentre prospective cohort study.SettingNational Health Service secondary care health organisations (trusts) in England between 1 September 2020 and 30 April 2021.ParticipantsClinical, support, and administrative staff enrolled in the SARS-CoV-2 Immunity and Reinfection Evaluation (SIREN) study with no evidence of previous infection. Vaccination status was obtained from national covid-19 vaccination registries and self-reported.Main outcome measureSARS-CoV-2 infection confirmed by polymerase chain reaction. Mixed effects logistic regression was conducted to determine demographic and occupational risk factors for infection, and an individual based mathematical model was used to predict how large the burden could have been if vaccines had not been available from 8 December 2020 .ResultsDuring England’s second wave, 12.9% (2353/18 284) of susceptible SIREN participants became infected with SARS-CoV-2. Infections peaked in late December 2020 and decreased from January 2021, concurrent with the cohort’s rapid vaccination coverage and a national lockdown. In multivariable analysis, factors increasing the likelihood of infection in the second wave were being under 25 years old (20.3% (132/651); adjusted odds ratio 1.35, 95% confidence interval 1.07 to 1.69), living in a large household (15.8% (282/1781); 1.54, 1.23 to 1.94, for participants from households of five or more people), having frequent exposure to patients with covid-19 (19.2% (723/3762); 1.79, 1.56 to 2.06, for participants with exposure every shift), working in an emergency department or inpatient ward setting (20.8% (386/1855); 1.76, 1.45 to 2.14), and being a healthcare assistant (18.1% (267/1479); 1.43, 1.16 to 1.77). Time to first vaccination emerged as being strongly associated with infection (PConclusionsThe rapid covid-19 vaccine rollout from December 2020 averted infection in a large proportion of hospital healthcare workers in England: without vaccines, second wave infections could have been 69% higher. With booster vaccinations being needed for adequate protection from the omicron variant, and perhaps the need for further boosters for future variants, ensuring equitable delivery to healthcare workers is essential. The findings also highlight occupational risk factors that persisted in healthcare workers despite vaccine rollout; a greater understanding of the transmission dynamics responsible for these is needed to help to optimise the infection prevention and control policies that protect healthcare workers from infection and therefore to support staffing levels and maintain healthcare provision.Trial registrationISRCTN registryISRCTN11041050.

Published
2022

7. Burden of SARS-CoV-2 infection in healthcare workers during second wave in England and impact of vaccines: prospective multicentre cohort study (SIREN) and mathematical model

Author

Pople, Diane, primary, Monk, Edward J M, additional, Evans, Stephanie, additional, Foulkes, Sarah, additional, Islam, Jasmin, additional, Wellington, Edgar, additional, Atti, Ana, additional, Hope, Russell, additional, Robotham, Julie, additional, Hopkins, Susan, additional, Brown, Colin S, additional, and Hall, Victoria J, additional

Published
2022
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8. The social representations on the healthdisease process in spiritual vision

Author

Joel Lobato da Costa, Sílvio Éder Dias da Silva, Arielle Lima dos Santos, Wellington Edgar de Lacerda HAatherly, Jeferson Santos Araújo, and Layza Gabriella Lopes de Miranda

Subjects
03 medical and health sciences, 030505 public health, 030504 nursing, General Computer Science, 0305 other medical science
Abstract

Objetivo: Identificar as Representações Sociais sobre o processo saúde-doença no Espiritismo.Método: Estudo descritivo com abordagem qualitativa. Utilizados na pesquisa conceitos das Representações Sociais de acordo com Serge Moscovici. A coleta dos dados ocorreu através de entrevista semi-estruturada e aplicação da técnica livre associação de palavras e observação Livre. Resultados: O espiritismo crê que conquistamos a saúde quando estamos harmonizados conosco e com as leis divinas. Qualquer descumprimento dessas leis divinas gera um desequilíbrio no ser humano.Conclusão: A Enfermagem necessita reconhecer essas Representações Sociais, visto que elas irão esclarecer aos profissionais as experiências de pacientes religiosos, o modo como assimilam seu estado patológico e isto é um desafio para articulação de estratégias de aproximação.

Published
2021
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9. Protection against SARS-CoV-2 after Covid-19 Vaccination and Previous Infection

Author

Hall, Victoria, Foulkes, Sarah, Insalata, Ferdinando, Kirwan, Peter, Saei, Ayoub, Atti, Ana, Wellington, Edgar, Khawam, Jameel, Munro, Katie, Cole, Michelle, Tranquillini, Caio, Taylor-Kerr, Andrew, Hettiarachchi, Nipunadi, Calbraith, Davina, Sajedi, Noshin, Milligan, Iain, Themistocleous, Yrene, Corrigan, Diane, Cromey, Lisa, Price, Lesley, Stewart, Sally, De Lacy, Elen, Norman, Chris, Linley, Ezra, Otter, Ashley D, Semper, Amanda, Hewson, Jacqueline, D'Arcangelo, Silvia, Chand, Meera, Brown, Colin S, Brooks, Tim, Islam, Jasmin, Charlett, Andre, Hopkins, Susan, SIREN Study Group, Hall, Victoria [0000-0001-8744-4277], Kirwan, Peter [0000-0001-6904-0500], Atti, Ana [0000-0001-6768-6586], Tranquillini, Caio [0000-0001-9478-2557], Sajedi, Noshin [0000-0001-7550-894X], Brooks, Tim [0000-0002-3783-1284], Apollo - University of Cambridge Repository, University of St Andrews. School of Medicine, and University of St Andrews. Infection and Global Health Division

Subjects
COVID-19 Vaccines, COVID-19/diagnosis, COVID-19 nucleic acid testing, Health Personnel, Vaccine efficacy, Vaccine Efficacy, Adaptive Immunity, SDG 3 - Good Health and Well-being, BNT162 vaccine/therapeutic use, ChAdOx1 nCoV-19, Humans, Vaccination/methods, QR180 Immunology, Prospective Studies, BNT162 Vaccine, ChAdOx1 nCoV-19/therapeutic use, SARS-CoV-2, Vaccination, COVID-19, 3rd-DAS, General Medicine, Health personnel, Asymptomatic diseases, United Kingdom, COVID-19 vaccines/immunology, COVID-19 Nucleic Acid Testing, QR180, Asymptomatic Diseases, Adaptive immunity/immunology, Prospective studies
Abstract

Supported by the U.K. Health Security Agency, the U.K. Department of Health and Social Care (with contributions from the governments in Northern Ireland, Wales, and Scotland), the National Institute for Health Research, and grants from the Medical Research Council. Background: The duration and effectiveness of immunity from infection with and vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are relevant to pandemic policy interventions, including the timing of vaccine boosters. Methods: We investigated the duration and effectiveness of immunity in a prospective cohort of asymptomatic health care workers in the United Kingdom who underwent routine polymerase-chain-reaction (PCR) testing. Vaccine effectiveness (≤10 months after the first dose of vaccine) and infection-acquired immunity were assessed by comparing the time to PCR-confirmed infection in vaccinated persons with that in unvaccinated persons, stratified according to previous infection status. We used a Cox regression model with adjustment for previous SARS-CoV-2 infection status, vaccine type and dosing interval, demographic characteristics, and workplace exposure to SARS-CoV-2. Results: Of 35,768 participants, 27% (9488) had a previous SARS-CoV-2 infection. Vaccine coverage was high: 95% of the participants had received two doses (78% had received BNT162b2 vaccine [Pfizer-BioNTech] with a long interval between doses, 9% BNT162b2 vaccine with a short interval between doses, and 8% ChAdOx1 nCoV-19 vaccine [AstraZeneca]). Between December 7, 2020, and September 21, 2021, a total of 2747 primary infections and 210 reinfections were observed. Among previously uninfected participants who received long-interval BNT162b2 vaccine, adjusted vaccine effectiveness decreased from 85% (95% confidence interval [CI], 72 to 92) 14 to 73 days after the second dose to 51% (95% CI, 22 to 69) at a median of 201 days (interquartile range, 197 to 205) after the second dose; this effectiveness did not differ significantly between the long-interval and short-interval BNT162b2 vaccine recipients. At 14 to 73 days after the second dose, adjusted vaccine effectiveness among ChAdOx1 nCoV-19 vaccine recipients was 58% (95% CI, 23 to 77) - considerably lower than that among BNT162b2 vaccine recipients. Infection-acquired immunity waned after 1 year in unvaccinated participants but remained consistently higher than 90% in those who were subsequently vaccinated, even in persons infected more than 18 months previously. Conclusions: Two doses of BNT162b2 vaccine were associated with high short-term protection against SARS-CoV-2 infection; this protection waned considerably after 6 months. Infection-acquired immunity boosted with vaccination remained high more than 1 year after infection. Publisher PDF

Published
2022

10. Protection against SARS-CoV-2 after Covid-19 Vaccination and Previous Infection

Author

Hall, Victoria, primary, Foulkes, Sarah, additional, Insalata, Ferdinando, additional, Kirwan, Peter, additional, Saei, Ayoub, additional, Atti, Ana, additional, Wellington, Edgar, additional, Khawam, Jameel, additional, Munro, Katie, additional, Cole, Michelle, additional, Tranquillini, Caio, additional, Taylor-Kerr, Andrew, additional, Hettiarachchi, Nipunadi, additional, Calbraith, Davina, additional, Sajedi, Noshin, additional, Milligan, Iain, additional, Themistocleous, Yrene, additional, Corrigan, Diane, additional, Cromey, Lisa, additional, Price, Lesley, additional, Stewart, Sally, additional, de Lacy, Elen, additional, Norman, Chris, additional, Linley, Ezra, additional, Otter, Ashley D., additional, Semper, Amanda, additional, Hewson, Jacqueline, additional, D’Arcangelo, Silvia, additional, Chand, Meera, additional, Brown, Colin S., additional, Brooks, Tim, additional, Islam, Jasmin, additional, Charlett, Andre, additional, and Hopkins, Susan, additional

Published
2022
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11. T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study

Author

Angyal, Adrienn, primary, Longet, Stephanie, additional, Moore, Shona C, additional, Payne, Rebecca P, additional, Harding, Adam, additional, Tipton, Tom, additional, Rongkard, Patpong, additional, Ali, Mohammad, additional, Hering, Luisa M, additional, Meardon, Naomi, additional, Austin, James, additional, Brown, Rebecca, additional, Skelly, Donal, additional, Gillson, Natalie, additional, Dobson, Sue L, additional, Cross, Andrew, additional, Sandhar, Gurjinder, additional, Kilby, Jonathan A, additional, Tyerman, Jessica K, additional, Nicols, Alexander R, additional, Spegarova, Jarmila S, additional, Mehta, Hema, additional, Hornsby, Hailey, additional, Whitham, Rachel, additional, Conlon, Christopher P, additional, Jeffery, Katie, additional, Goulder, Philip, additional, Frater, John, additional, Dold, Christina, additional, Pace, Matthew, additional, Ogbe, Ane, additional, Brown, Helen, additional, Ansari, M Azim, additional, Adland, Emily, additional, Brown, Anthony, additional, Chand, Meera, additional, Shields, Adrian, additional, Matthews, Philippa C, additional, Hopkins, Susan, additional, Hall, Victoria, additional, James, William, additional, Rowland-Jones, Sarah L, additional, Klenerman, Paul, additional, Dunachie, Susanna, additional, Richter, Alex, additional, Duncan, Christopher J A, additional, Barnes, Eleanor, additional, Carroll, Miles, additional, Turtle, Lance, additional, de Silva, Thushan I, additional, Watson, Adam, additional, Angyal, Adrienn, additional, Alhussni, Ahmed, additional, Nicols, Alexander, additional, Deeks, Alexandra, additional, Webb-Bridges, Alice, additional, Jämsén, Anni, additional, Chawla, Anu, additional, Duncan, Christopher, additional, Conlon, Christopher, additional, O'Donnell, Denise, additional, Weeks, Esme, additional, Abuelgasim, Hibatullah, additional, Xiao, Huiyuan, additional, Spegarova, Jarmila, additional, Holmes, Jennifer, additional, Haworth, Jenny, additional, Tyerman, Jessica, additional, Kilby, Jonathan, additional, Cutteridge, Joseph, additional, Lillie, Katy, additional, Romaniuk, Leigh, additional, Denly, Lucy, additional, Hering, Luisa, additional, Ansari, M. Azim, additional, Kasanyinga, Mwila, additional, Matthews, Philippa, additional, Payne, Rebecca, additional, Wilson, Robert, additional, Rowland-Jones, Sarah, additional, Thomas, Sarah, additional, Moore, Shona, additional, Gardiner, Siobhan, additional, Tucker, Stephanie, additional, Dobson, Sue, additional, Adlou, Syed, additional, de Silva, Thushan, additional, Lawrie, Allan, additional, Smith, Nikki, additional, Turton, Helena, additional, Zawia, Amira, additional, Bayley, Martin, additional, Fairman, Alex, additional, Harrington, Kate, additional, Kirk, Rosemary, additional, Marsh, Louise, additional, Watson, Lisa, additional, Wood, Steven, additional, Diffey, Benjamin, additional, Jones, Chris, additional, Lett, Lauren, additional, Platt, Gareth, additional, Subramaniam, Krishanthi, additional, Wootton, Daniel, additional, Payne, Brendan, additional, Hambleton, Sophie, additional, Kelly, Sinead, additional, Marston, Judith, additional, Poolan, Sonia, additional, Turner, Dianne, additional, Haniffa, Muzlifah, additional, Stephenson, Emily, additional, Adele, Sandra, additional, Akhter, Hossain Delowar, additional, Chinnakannan, Senthil, additional, de Lara, Catherine, additional, Donnison, Timothy, additional, Hackstein, Carl-Philipp, additional, Lee, Lian, additional, Lim, Nicholas, additional, Malone, Tom, additional, Phillips, Eloise, additional, Ramamurthy, Narayan, additional, Robinson, Nichola, additional, Sampson, Oliver, additional, Eyre, David, additional, Simmons, Beatrice, additional, Stafford, Lizzie, additional, Mentzer, Alexander, additional, Amini, Ali, additional, Arancibia-Cárcamo, Carolina, additional, Provine, Nicholas, additional, Travis, Simon, additional, Dimitriadis, Stavros, additional, Johnson, Sile, additional, Foulkes, Sarah, additional, Khawam, Jameel, additional, Wellington, Edgar, additional, Gilbert-Jaramillo, Javier, additional, Knight, Michael, additional, Dupont, Maeva, additional, Horner, Emily, additional, Thaventhiran, James, additional, and Chalk, Jeremy, additional

Published
2022
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12. The social representations on the healthdisease process in spiritual vision / As representações sociais sobre o processo saúde-doença na visão espírita

Author

HAatherly, Wellington Edgar de Lacerda, da Silva, Silvio Éder Dias, de Miranda, Layza Gabriella Lopes, dos Santos, Arielle Lima, Araújo, Jeferson Santos, and da Costa, Joel Lobato

Subjects
Liberdade religiosa, Percepção social, Espiritualismo, Enfermagem.Psicologia Social. Saúde publica, Enfermagem, Religião
Abstract

Objetivo: Identificar as Representações Sociais sobre o processo saúde-doença no Espiritismo.Método: Estudo descritivo com abordagem qualitativa. Utilizados na pesquisa conceitos das Representações Sociais de acordo com Serge Moscovici. A coleta dos dados ocorreu através de entrevista semi-estruturada e aplicação da técnica livre associação de palavras e observação Livre. Resultados: O espiritismo crê que conquistamos a saúde quando estamos harmonizados conosco e com as leis divinas. Qualquer descumprimento dessas leis divinas gera um desequilíbrio no ser humano.Conclusão: A Enfermagem necessita reconhecer essas Representações Sociais, visto que elas irão esclarecer aos profissionais as experiências de pacientes religiosos, o modo como assimilam seu estado patológico e isto é um desafio para articulação de estratégias de aproximação.

Published
2021

13. COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study

Author

Hall, Victoria Jane, primary, Foulkes, Sarah, additional, Saei, Ayoub, additional, Andrews, Nick, additional, Oguti, Blanche, additional, Charlett, Andre, additional, Wellington, Edgar, additional, Stowe, Julia, additional, Gillson, Natalie, additional, Atti, Ana, additional, Islam, Jasmin, additional, Karagiannis, Ioannis, additional, Munro, Katie, additional, Khawam, Jameel, additional, Chand, Meera A, additional, Brown, Colin S, additional, Ramsay, Mary, additional, Lopez-Bernal, Jamie, additional, Hopkins, Susan, additional, Andrews, N, additional, Atti, A, additional, Aziz, H, additional, Brooks, T, additional, Brown, CS, additional, Camero, D, additional, Carr, C, additional, Chand, MA, additional, Charlett, A, additional, Crawford, H, additional, Cole, M, additional, Conneely, J, additional, D'Arcangelo, S, additional, Ellis, J, additional, Evans, S, additional, Foulkes, S, additional, Gillson, N, additional, Gopal, R, additional, Hall, L, additional, Hall, VJ, additional, Harrington, P, additional, Hopkins, S, additional, Hewson, J, additional, Hoschler, K, additional, Ironmonger, D, additional, Islam, J, additional, Kall, M, additional, Karagiannis, I, additional, Kay, O, additional, Khawam, J, additional, King, E, additional, Kirwan, P, additional, Kyffin, R, additional, Lackenby, A, additional, Lattimore, M, additional, Linley, E, additional, Lopez-Bernal, J, additional, Mabey, L, additional, McGregor, R, additional, Miah, S, additional, Monk, EJM, additional, Munro, K, additional, Naheed, Z, additional, Nissr, A, additional, O'Connell, AM, additional, Oguti, B, additional, Okafor, H, additional, Organ, S, additional, Osbourne, J, additional, Otter, A, additional, Patel, M, additional, Platt, S, additional, Pople, D, additional, Potts, K, additional, Ramsay, M, additional, Robotham, J, additional, Rokadiya, S, additional, Rowe, C, additional, Saei, A, additional, Sebbage, G, additional, Semper, A, additional, Shrotri, M, additional, Simmons, R, additional, Soriano, A, additional, Staves, P, additional, Taylor, S, additional, Taylor, A, additional, Tengbe, A, additional, Tonge, S, additional, Vusirikala, A, additional, Wallace, S, additional, Wellington, E, additional, Zambon, M, additional, Corrigan, D, additional, Sartaj, M, additional, Cromey, L, additional, Campbell, S, additional, Braithwaite, K, additional, Price, L, additional, Haahr, L, additional, Stewart, S, additional, Lacey, ED, additional, Partridge, L, additional, Stevens, G, additional, Ellis, Y, additional, Hodgson, H, additional, Norman, C, additional, Larru, B, additional, Mcwilliam, S, additional, Roynon, A, additional, Northfield, J, additional, Winchester, S, additional, Cieciwa, P, additional, Pai, A, additional, Bakker, P, additional, Loughrey, C, additional, Watt, A, additional, Adair, F, additional, Hawkins, A, additional, Grant, A, additional, Temple-Purcell, R, additional, Howard, J, additional, Slawson, N, additional, Subudhi, C, additional, Davies, S, additional, Bexley, A, additional, Penn, R, additional, Wong, N, additional, Boyd, G, additional, Rajgopal, A, additional, Arenas-Pinto, A, additional, Matthews, R, additional, Whileman, A, additional, Laugharne, R, additional, Ledger, J, additional, Barnes,, T, additional, Jones, C, additional, Osuji, N, additional, Chitalia, N, additional, Bailey, T, additional, Akhtar, S, additional, Harrison, G, additional, Horne, S, additional, Walker, N, additional, Agwuh, K, additional, Maxwell, V, additional, Graves, J, additional, Williams, S, additional, O'Kelly, A, additional, Ridley, P, additional, Cowley, A, additional, Johnstone, H, additional, Swift, P, additional, Democratis, J, additional, Meda, M, additional, Brake, S, additional, Gunn, J, additional, Selassi, A, additional, Hams, S, additional, Irvine, V, additional, Chandrasekaran, B, additional, Forsyth, C, additional, Radmore, J, additional, Thomas, C, additional, Brown, K, additional, Roberts, S, additional, Burns, P, additional, Gajee, K, additional, Lewis, T, additional, Byrne, TM, additional, Sanderson, F, additional, Knight, S, additional, Macnaughton, E, additional, Burton, BJL, additional, Smith, H, additional, Chaudhuri, R, additional, Aeron-Thomas, J, additional, Hollinshead, K, additional, Shorten, RJ, additional, Swan, A, additional, Favager, C, additional, Murira, J, additional, Baillon, S, additional, Hamer, S, additional, Shah, A, additional, Russell, J, additional, Brennan, D, additional, Dave, A, additional, Chawla, A, additional, Westwell, F, additional, Adeboyeku, D, additional, Papineni, P, additional, Pegg, C, additional, Williams, M, additional, Ahmad, S, additional, Horsley, A, additional, Gabriel, C, additional, Pagget, K, additional, Maloney, G, additional, Ashcroft, J, additional, Del Rosario, I, additional, Crosby-Nwaobi, R, additional, Flanagan, D, additional, Dhasmana, D, additional, Fowler, S, additional, Cameron, E, additional, Prentice, L, additional, Sinclair, C, additional, Bateman, V, additional, McLelland-Brooks, K, additional, Ho, A, additional, Murphy, M, additional, Cochrane, A, additional, Gibson, A, additional, Black, K, additional, Tempeton, K, additional, Donaldson, S, additional, Coke, L, additional, Elumogo, N, additional, Elliott, J, additional, Padgett, D, additional, Cross, A, additional, Mirfenderesky, M, additional, Joyce, S, additional, Sinanovic, I, additional, Howard, M, additional, Cowling, P, additional, Brazil, M, additional, Hanna, E, additional, Abdelrazik, A, additional, Brand, S, additional, Sheridan, EA, additional, Wadams, B, additional, Lloyd, A, additional, Mouland, J, additional, Giles, J, additional, Pottinger, G, additional, Coles, H, additional, Joseph, M, additional, Lee, M, additional, Orr, S, additional, Chenoweth, H, additional, Browne, D, additional, Auckland, C, additional, Lear, R, additional, Mahungu, T, additional, Rodger, A, additional, Warren, S, additional, Brooking, D, additional, Pai, S, additional, Druyeh, R, additional, Smith, E, additional, Stone, S, additional, Meisner, S, additional, Delgado, D, additional, Underhill, E, additional, Keen, L, additional, Aga, M, additional, Domingos, P, additional, Gormley, S, additional, Kerrison, C, additional, Birch, S, additional, DeSilva, T, additional, Allsop, L, additional, Ambalkar, S, additional, Beekes, M, additional, Jose, S, additional, Tomlinson, J, additional, Painter, Sharen, additional, Price, C, additional, Pepperell, J, additional, James, K, additional, Trinick, T, additional, Moore, L, additional, Day, J, additional, Boulos, A, additional, Knox, I, additional, Defever, E, additional, McCracken, D, additional, Gray, K, additional, Houston, A, additional, Planche, T, additional, Pritchard Jones, R, additional, Wycherley, Diane, additional, Bennett, S, additional, Marrs, J, additional, Nimako, K, additional, Stewart, B, additional, Bain, SC, additional, Kalakonda, N, additional, Khanduri, S, additional, Ashby, A, additional, Holden, M, additional, Mahabir, N, additional, Harwood, J, additional, Payne, B, additional, Court, K, additional, White, N, additional, Longfellow, R, additional, Hughes, LE, additional, Green, ME, additional, Halkes, M, additional, Mercer, P, additional, Roebuck, A, additional, Wilson-Davies, E, additional, Gallego, L, additional, Lazarus, R, additional, Aldridge, N, additional, Berry, L, additional, Game, F, additional, Reynolds, T, additional, Holmes, C, additional, Wiselka, M, additional, Higham, A, additional, Booth, M, additional, Duff, C, additional, Alderton, J, additional, Hilton, D, additional, Powell, J, additional, Jackson, A, additional, Plant, AJ, additional, Ahmed, N, additional, Chin, T, additional, Qazzafi, MZ, additional, Moody, AM, additional, Tilley, RE, additional, Donaghy, T, additional, O'Kane, M, additional, Shipman, K, additional, Sierra, R, additional, Parmar, C, additional, Mills, G, additional, Harvey, D, additional, Huang, YWJ, additional, Birch, J, additional, Robinson, L, additional, Board, S, additional, Broadley, A, additional, Laven, C, additional, Todd, N, additional, Eyre, DW, additional, Jeffery, K, additional, Dunachie, S, additional, Duncan, C, additional, Klenerman, P, additional, Turtle, L, additional, Baxendale, H, additional, and Heeney, JL, additional

Published
2021
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14. SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN)

Author

Hall, Victoria Jane, primary, Foulkes, Sarah, additional, Charlett, Andre, additional, Atti, Ana, additional, Monk, Edward J M, additional, Simmons, Ruth, additional, Wellington, Edgar, additional, Cole, Michelle J, additional, Saei, Ayoub, additional, Oguti, Blanche, additional, Munro, Katie, additional, Wallace, Sarah, additional, Kirwan, Peter D, additional, Shrotri, Madhumita, additional, Vusirikala, Amoolya, additional, Rokadiya, Sakib, additional, Kall, Meaghan, additional, Zambon, Maria, additional, Ramsay, Mary, additional, Brooks, Tim, additional, Brown, Colin S, additional, Chand, Meera A, additional, Hopkins, Susan, additional, Andrews, N, additional, Atti, A, additional, Aziz, H, additional, Brooks, T, additional, Brown, CS, additional, Camero, D, additional, Carr, C, additional, Chand, MA, additional, Charlett, A, additional, Crawford, H, additional, Cole, M, additional, Conneely, J, additional, D'Arcangelo, S, additional, Ellis, J, additional, Evans, S, additional, Foulkes, S, additional, Gillson, N, additional, Gopal, R, additional, Hall, L, additional, Hall, VJ, additional, Harrington, P, additional, Hopkins, S, additional, Hewson, J, additional, Hoschler, K, additional, Ironmonger, D, additional, Islam, J, additional, Kall, M, additional, Karagiannis, I, additional, Kay, O, additional, Khawam, J, additional, King, E, additional, Kirwan, P, additional, Kyffin, R, additional, Lackenby, A, additional, Lattimore, M, additional, Linley, E, additional, Lopez-Bernal, J, additional, Mabey, L, additional, McGregor, R, additional, Miah, S, additional, Monk, EJM, additional, Munro, K, additional, Naheed, Z, additional, Nissr, A, additional, O'Connell, AM, additional, Oguti, B, additional, Okafor, H, additional, Organ, S, additional, Osbourne, J, additional, Otter, A, additional, Patel, M, additional, Platt, S, additional, Pople, D, additional, Potts, K, additional, Ramsay, M, additional, Robotham, J, additional, Rokadiya, S, additional, Rowe, C, additional, Saei, A, additional, Sebbage, G, additional, Semper, A, additional, Shrotri, M, additional, Simmons, R, additional, Soriano, A, additional, Staves, P, additional, Taylor, S, additional, Taylor, A, additional, Tengbe, A, additional, Tonge, S, additional, Vusirikala, A, additional, Wallace, S, additional, Wellington, E, additional, Zambon, M, additional, Corrigan, D, additional, Sartaj, M, additional, Cromey, L, additional, Campbell, S, additional, Braithwaite, K, additional, Price, L, additional, Haahr, L, additional, Stewart, S, additional, Lacey, ED, additional, Partridge, L, additional, Stevens, G, additional, Ellis, Y, additional, Hodgson, H, additional, Norman, C, additional, Larru, B, additional, Mcwilliam, S, additional, Winchester, S, additional, Cieciwa, P, additional, Pai, A, additional, Loughrey, C, additional, Watt, A, additional, Adair, F, additional, Hawkins, A, additional, Grant, A, additional, Temple-Purcell, R, additional, Howard, J, additional, Slawson, N, additional, Subudhi, C, additional, Davies, S, additional, Bexley, A, additional, Penn, R, additional, Wong, N, additional, Boyd, G, additional, Rajgopal, A, additional, Arenas-Pinto, A, additional, Matthews, R, additional, Whileman, A, additional, Laugharne, R, additional, Ledger, J, additional, Barnes, T, additional, Jones, C, additional, Botes, D, additional, Chitalia, N, additional, Akhtar, S, additional, Harrison, G, additional, Horne, S, additional, Walker, N, additional, Agwuh, K, additional, Maxwell, V, additional, Graves, J, additional, Williams, S, additional, O'Kelly, A, additional, Ridley, P, additional, Cowley, A, additional, Johnstone, H, additional, Swift, P, additional, Democratis, J, additional, Meda, M, additional, Callens, C, additional, Beazer, S, additional, Hams, S, additional, Irvine, V, additional, Chandrasekaran, B, additional, Forsyth, C, additional, Radmore, J, additional, Thomas, C, additional, Brown, K, additional, Roberts, S, additional, Burns, P, additional, Gajee, K, additional, Byrne, TM, additional, Sanderson, F, additional, Knight, S, additional, Macnaughton, E, additional, Burton, BJL, additional, Smith, H, additional, Chaudhuri, R, additional, Hollinshead, K, additional, Shorten, RJ, additional, Swan, A, additional, Favager, C, additional, Murira, J, additional, Baillon, S, additional, Hamer, S, additional, Gantert, K, additional, Russell, J, additional, Brennan, D, additional, Dave, A, additional, Chawla, A, additional, Westell, F, additional, Adeboyeku, D, additional, Papineni, P, additional, Pegg, C, additional, Williams, M, additional, Ahmad, S, additional, Ingram, S, additional, Gabriel, C, additional, Pagget, K, additional, Maloney, G, additional, Ashcroft, J, additional, Del Rosario, I, additional, Crosby-Nwaobi, R, additional, Reeks, C, additional, Fowler, S, additional, Prentice, L, additional, Spears, M, additional, McKerron, G, additional, McLelland-Brooks, K, additional, Anderson, J, additional, Donaldson, S, additional, Templeton, K, additional, Coke, L, additional, Elumogo, N, additional, Elliott, J, additional, Padgett, D, additional, Mirfenderesky, M, additional, Cross, A, additional, Price, J, additional, Joyce, S, additional, Sinanovic, I, additional, Howard, M, additional, Lewis, T, additional, Cowling, P, additional, Potoczna, D, additional, Brand, S, additional, Sheridan, L, additional, Wadams, B, additional, Lloyd, A, additional, Mouland, J, additional, Giles, J, additional, Pottinger, G, additional, Coles, H, additional, Joseph, M, additional, Lee, M, additional, Orr, S, additional, Chenoweth, H, additional, Auckland, C, additional, Lear, R, additional, Mahungu, T, additional, Rodger, A, additional, Penny-Thomas, K, additional, Pai, S, additional, Zamikula, J, additional, Smith, E, additional, Stone, S, additional, Boldock, E, additional, Howcroft, D, additional, Thompson, C, additional, Aga, M, additional, Domingos, P, additional, Gormley, S, additional, Kerrison, C, additional, Marsh, L, additional, Tazzyman, S, additional, Allsop, L, additional, Ambalkar, S, additional, Beekes, M, additional, Jose, S, additional, Tomlinson, J, additional, Jones, A, additional, Price, C, additional, Pepperell, J, additional, Schultz, M, additional, Day, J, additional, Boulos, A, additional, Defever, E, additional, McCracken, D, additional, Gray, K, additional, Houston, A, additional, Planche, T, additional, Pritchard Jones, R, additional, Wycherley, Diane, additional, Bennett, S, additional, Marrs, J, additional, Nimako, K, additional, Stewart, B, additional, Kalakonda, N, additional, Khanduri, S, additional, Ashby, A, additional, Holden, M, additional, Mahabir, N, additional, Harwood, J, additional, Payne, B, additional, Court, K, additional, Staines, N, additional, Longfellow, R, additional, Green, ME, additional, Hughes, LE, additional, Halkes, M, additional, Mercer, P, additional, Roebuck, A, additional, Wilson-Davies, E, additional, Gallego, L, additional, Lazarus, R, additional, Aldridge, N, additional, Berry, L, additional, Game, F, additional, Reynolds, T, additional, Holmes, C, additional, Wiselka, M, additional, Higham, A, additional, Booth, M, additional, Duff, C, additional, Alderton, J, additional, Jory, H, additional, Virgilio, E, additional, Chin, T, additional, Qazzafi, MZ, additional, Moody, AM, additional, Tilley, R, additional, Donaghy, T, additional, Shipman, K, additional, Sierra, R, additional, Jones, N, additional, Mills, G, additional, Harvey, D, additional, Huang, YWJ, additional, Birch, J, additional, Robinson, L, additional, Board, S, additional, Broadley, A, additional, Laven, C, additional, Todd, N, additional, Eyre, DW, additional, Jeffery, K, additional, Dunachie, S, additional, Duncan, C, additional, Klenerman, P, additional, Turtle, L, additional, De Silva, T, additional, Baxendale, H, additional, and Heeney, JL, additional

Published
2021
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16. Effectiveness of BNT162b2 mRNA Vaccine Against Infection and COVID-19 Vaccine Coverage in Healthcare Workers in England, Multicentre Prospective Cohort Study (the SIREN Study)

Author

Hall, Victoria Jane, primary, Foulkes, Sarah, additional, Saei, Ayoub, additional, Andrews, Nick, additional, Oguti, Blanche, additional, Charlett, Andre, additional, Wellington, Edgar, additional, Stowe, Julia, additional, Gillson, Natalie, additional, Atti, Ana, additional, Islam, Jasmin, additional, Karagiannis, Ioannis, additional, Munro, Katie, additional, Khawam, Jameel, additional, Group, The SIREN Study, additional, Chand, Meera A., additional, Brown, Colin, additional, Ramsay, Mary E., additional, Bernal, Jamie Lopez, additional, and Hopkins, Susan, additional

Published
2021
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17. Do Antibody Positive Healthcare Workers Have Lower SARS-CoV-2 Infection Rates than Antibody Negative Healthcare Workers? Large Multi-Centre Prospective Cohort Study (The SIREN Study), England: June to November 2020

Author

Hall, Victoria Jane, primary, Foulkes, Sarah, additional, Charlett, Andre, additional, Atti, Ana, additional, Monk, Edward JM, additional, Simmons, Ruth, additional, Wellington, Edgar, additional, Cole, Michelle, additional, Saei, Ayoub, additional, Oguti, Blanche, additional, Munro, Katie, additional, Wallace, S., additional, Kirwan, Peter D., additional, Shrotri, Madhumita, additional, Vusirikala, Amoolya, additional, Rokadiya, Sakib, additional, Kall, Meaghan, additional, Zambon, Maria, additional, Ramsay, Mary E., additional, Brooks, T., additional, Group, SIREN Study, additional, Brown, Colin, additional, Chand, Meera A., additional, and Hopkins, Susan, additional

Published
2021
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18. THE SOCIAL REPRESENTATIONS ON THE HEALTH-DISEASE PROCESS IN SPIRITUAL VISION.

Author

Dias da Silva, Silvio Éder, de Lacerda Hatherly, Wellington Edgar, Lopes de Miranda, Layza Gabriella, Lima dos Santos, Arielle, Santos Araújo, Jeferson, and Lobato da Costa, Joel

Abstract

Copyright of Revista de Pesquisa: Cuidado é Fundamental is the property of Revista de Pesquisa: Cuidado e Fundamental Online and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021
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19. Improving feedback of surveillance data on antimicrobial consumption, resistance and stewardship in England: putting the data at your Fingertips

Author

Johnson, Alan P., primary, Muller-Pebody, Berit, additional, Budd, Emma, additional, Ashiru-Oredope, Diane, additional, Ladenheim, David, additional, Hain, Doris, additional, Hope, Russell, additional, Bhattacharya, Alex, additional, Elgohari, Suzanne, additional, Guy, Rebecca, additional, Henderson, Katherine, additional, Puleston, Richard, additional, Rooney, Graeme, additional, Thelwall, Simon, additional, Wellington, Edgar, additional, Lamagni, Theresa, additional, and Hopkins, Susan, additional

Published
2016
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20. Improving feedback of surveillance data on antimicrobial consumption, resistance and stewardship in England: putting the data at your Fingertips.

Author

Johnson, Alan P., Muller-Pebody, Berit, Budd, Emma, Ashiru-Oredope, Diane, Ladenheim, David, Hain, Doris, Hope, Russell, Bhattacharya, Alex, Elgohari, Suzanne, Guy, Rebecca, Henderson, Katherine, Puleston, Richard, Rooney, Graeme, Thelwall, Simon, Wellington, Edgar, Lamagni, Theresa, and Hopkins, Susan

Subjects
ANTI-infective agents, DRUG resistance in bacteria, HEALTH outcome assessment, DRUG prescribing, DATA analysis
Abstract

The provision of better access to and use of surveillance data is a key component of the UK 5 Year Antimicrobial Resistance (AMR) Strategy. Since April 2016, PHE has made data on practice (infection prevention and control; antimicrobial stewardship) and outcome (prevalence of AMR, antibiotic use and healthcare-associated infections) available through Fingertips, a publicly accessible web tool (https://fingertips.phe.org.uk/profile/amr-local-indicators). Fingertips provides access to a wide range of public health data presented as thematic profiles, with the above data being available through the 'AMR local indicators' profile. Local data on a range of indicators can be viewed at the level of National Health Service acute trusts, Clinical Commissioning Groups or general practitioner practices, all of which can be compared with the corresponding aggregate values for England to allow benchmarking. The data can be viewed in a range of formats including an overview showing counts and rates, interactive maps, spine charts and graphs that show temporal trends over a range of time scales or allow correlations between pairs of indicators. The aim of the AMR local indicators profile on Fingertips is to support the development of local action plans to optimize antibiotic prescribing and reduce AMR and healthcare-associated infections. Provision of access to relevant information in an easy to use format will help local stakeholders, including healthcare staff, commissioners, Directors of Public Health, academics and the public, to benchmark relevant local AMR data and to monitor the impact of local initiatives to tackle AMR over time. [ABSTRACT FROM AUTHOR]

Published
2017
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