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228 results on '"Welle, S"'

1. AB0752 HOW DOES TIME TO DIAGNOSIS AND GENDER AFFECT TREATMENT OUTCOMES IN PATIENTS WITH ANKYLOSING SPONDYLITIS OR PSORIATIC ARTHRITIS? – REAL WORLD DATA FROM THE GERMAN AQUILA STUDY WITH SECUKINUMAB

Author

Benesova, K., primary, Hansen, O., additional, Kiltz, U., additional, Brandt-Juergens, J., additional, Kästner, P., additional, Riechers, E., additional, Peterlik, D., additional, Budden, C., additional, Boas, A., additional, Welle, S., additional, and Tony, H. P., additional

Published
2022
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5. Steady-state and non-steady-state measurements of plasma glutamine turnover in humans

Author

Kreider, M.E., Stumvoll, M., Meyer, C., Overkamp, D., Welle, S., and Gerich, J.

Subjects
Glutamine -- Physiological aspects, Biological transport, Active -- Analysis, Glutamine metabolism -- Measurement, Biological sciences
Abstract

Nitrogen-, carbon- and hydrogen-labeled glutamine tracers were utilized to determine the differences in plasma glutamine turnover under steady-state and non-steady-state conditions in humans. Different steady-state glutamine fluxes were detected with the different glutamine tracers due to the recycling of carbon and nitrogen labels. On the other hand, accurate measurements of glutamine turnover were obtained under non-steady-state conditions by utilizing standard monocompartmental non-steady-state equations.

Published
1997

6. Regulation of gluconeogenesis by glutamine in normal postabsortive humans

Author

Perriello, G., Nurjhan, N., Stumvoll, M., Bucci, A., Welle, S., Dailey, G., Bier, D.M., Toft, I., Jenssen, T.G., and Gerich, J.E.

Subjects
Glutamine metabolism -- Physiological aspects, Gluconeogenesis -- Physiological aspects, Fatty acid metabolism -- Physiological aspects, Biological sciences
Abstract

The role of glutamine in gluconeogenesis was analyzed during glutamine infusions in normal human subjects. Infusion of postabsorptive volunteers with glutamine at a rate expected to approximate changes in glutamine turnover after a protein meal indicated the role of glutamine as a substrate and physiological regulator of gluconeogenesis. Furthermore, physiological increase in glutamine availability decreases its de novo synthesis and disproportionately increases its own incorporation into the plasma glucose.

Published
1997

20. Glutamine and alanine metabolism in NIDDM

Author

Stumvoll, M., primary, Perriello, G., additional, Nurjhan, N., additional, Bucci, A., additional, Welle, S., additional, Jansson, P. A., additional, Dailey, G., additional, Bier, D., additional, Jenssen, T., additional, and Gerich, J., additional

Published
1996
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38. Banisteriopsis elegans

Author

J. van Rooden, B. J. H. ter Welle, S. M. C. Topper, J. van Rooden, B. J. H. ter Welle, S. M. C. Topper, J. van Rooden, B. J. H. ter Welle, S. M. C. Topper, and J. van Rooden, B. J. H. ter Welle, S. M. C. Topper

Abstract

Angiosperms, http://name.umdl.umich.edu/IC-HERB00IC-X-1527282%5DMICH-V-1527282, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/1527282/MICH-V-1527282/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Published
1979

39. Heteropterys leona

Author

J. van Rooden, B. J. H. ter Welle & S. M. C. Topper, J. van Rooden, B. J. H. ter Welle & S. M. C. Topper, J. van Rooden, B. J. H. ter Welle & S. M. C. Topper, and J. van Rooden, B. J. H. ter Welle & S. M. C. Topper

Abstract

Angiosperms, http://name.umdl.umich.edu/IC-HERB00IC-X-1530307%5DMICH-V-1530307, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/1530307/MICH-V-1530307/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Published
1979

40. Expression of elongation factor-1 alpha and S1 in young and old human skeletal muscle.

Author

Welle, S, Thornton, C, Bhatt, K, and Krym, M

Subjects
*RNA analysis, *AGE distribution, *COMPARATIVE studies, *DOCUMENTATION, *RESEARCH methodology, *MEDICAL cooperation, *NUCLEOTIDES, *PROTEINS, *RESEARCH, *EVALUATION research, *SKELETAL muscle
Abstract

Previous research has indicated that reduced expression of elongation factor-1 alpha (EF-1 alpha) may be an important determinant of the reduced rate of protein synthesis in senescent animals and cultured cells. The present study examined whether expression of EF-1 alpha or S1, a homologous protein found exclusively in postmitotic tissues, is reduced in senescent human skeletal muscle. Muscle biopsies were obtained from the vastus lateralis muscles of healthy young (22-31 yr old) and old (61-74 yr old) subjects. As reported previously, myofibrillar protein synthesis was approximately 40% slower in the older muscle (p < .001) as determined by incorporation of a stable isotope. Immunoblotting revealed no difference in the concentration of EF-1 alpha + S1 between younger and older muscle. RT-PCR assays indicated that S1 mRNA was much more abundant than EF-1 alpha mRNA in muscles of both age groups, with no reduction in either EF-1 alpha or S1 mRNA abundance in older muscles. We conclude that expression of EF-1 alpha and S1 is not diminished in older muscles and does not explain the age-related slowing of protein synthesis in human skeletal muscle. However, we cannot exclude the possibility that the activity of these proteins declines during senescence due to post-translational modifications. [ABSTRACT FROM AUTHOR]

Published
1997
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46. Expression profile of FSHD supports a link between retinal vasculopathy and muscular dystrophy

Author

Osborne, R J., Welle, S, Venance, S L., Thornton, C A., and Tawil, R

Abstract

Facioscapulohumeral muscular dystrophy (FSHD) is caused by deletions within a tandem array of D4Z4 repeats on chromosome 4q35. In addition to muscle degeneration, most patients with FSHD develop abnormalities of the retinal vasculature. Previous work has suggested that muscle degeneration in FSHD results from increased expression of genes proximal to the deletion, including FRG1.

Published
2007
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47. Inventory of high-abundance mRNAs in skeletal muscle of normal men.

Author

Welle, S, Bhatt, K, and Thornton, C A

Abstract

G42875rial analysis of gene expression (SAGE) method was used to generate a catalog of 53,875 short (14 base) expressed sequence tags from polyadenylated RNA obtained from vastus lateralis muscle of healthy young men. Over 12,000 unique tags were detected. The frequency of occurrence of each tag reflects the relative abundance of the corresponding mRNA. The mRNA species that were detected 10 or more times, each comprising >/=0.02% of the mRNA population, accounted for 64% of the mRNA mass but <10% of the total number of mRNA species detected. Almost all of the abundant tags matched mRNA or EST sequences cataloged in GenBank. Mitochondrial transcripts accounted for approximately 20% of the polyadenylated RNA. Transcripts encoding proteins of the myofibrils were the most abundant nuclear-encoded mRNAs. Transcripts encoding ribosomal proteins, and those encoding proteins involved in energy metabolism, also were very abundant. The database can be used as a reference for investigations of alterations in gene expression associated with conditions that influence muscle function, such as muscular dystrophies, aging, and exercise.

Published
1999

49. Human IgG production in vivo: Determination of synthetic rate by nonradioactive tracer incorporation

Author

Thornton, C. A., Welle, S., Robert Griggs, and Abraham, G. N.

Subjects
Immunology, Immunology and Allergy
Abstract

Exposure of Ab-secreting cells to selected hormones, cytokines, and drugs alters the rate of Ig production in vitro. Whether these effects are important clinically is unknown because there are no safe, reproducible, and appropriate techniques for measuring Ig synthesis in vivo. We developed a stable isotope tracer method to measure IgG secretion into plasma. L-[1-13C]Leucine was given as a priming dose followed by a constant i.v. infusion over 8 h. Tracer accrual in IgG, determined by mass spectrometry, was linear from 2 to 8 h of the infusion. The normal rate of IgG synthesis into plasma assessed in 21 healthy subjects was 860 +/- 310 mg/day (mean +/- SD). The synthetic rate measurements were remarkably reproducible (coefficient of variation = 10.5 %). Simultaneous analysis of leucine kinetics allows, for the first time, Ig secretion to be studied in the context of whole body protein economy. IgG secretion into plasma accounts for 0.3% of whole body protein synthesis. Experimental support for a key metabolic assumption, that tracer enrichment in plasma and that at the site of IgG synthesis were similar, came from a comparison of synthetic rates derived from low dose and high dose tracer infusions. Measurement of Ig secretion by tracer incorporation is rapid and reproducible. In contrast to older methods that rely on radioisotope disappearance, the tracer incorporation method is safe for serial measurements in an individual and will be useful for quantitative studies of treatment effects and immune regulation in vivo.

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