1. Maximal regularity and optimal control for a non-local Cahn-Hilliard tumour growth model.
- Author
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Fornoni, Matteo
- Subjects
- *
CELLULAR evolution , *CELL proliferation , *CHEMOTAXIS , *REACTION-diffusion equations , *TUMORS , *EQUATIONS - Abstract
We consider a non-local tumour growth model of phase-field type, describing the evolution of tumour cells through proliferation in presence of a nutrient. The model consists of a coupled system, incorporating a non-local Cahn-Hilliard equation for the tumour phase variable and a reaction-diffusion equation for the nutrient. First, we establish novel regularity results for such a model, by applying maximal regularity theory in weighted L p spaces. This technique enables us to prove the local existence and uniqueness of a regular solution, including also chemotaxis effects. By leveraging time-regularisation properties and global boundedness estimates, we further extend the solution to a global one. These results provide the foundation for addressing an optimal control problem, aimed at identifying a suitable therapy, guiding the tumour towards a predefined target. Specifically, we prove the existence of an optimal therapy and, by studying the Fréchet-differentiability of the control-to-state operator and introducing the adjoint system, we derive first-order necessary optimality conditions. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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