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10 results on '"Wel, Twan"'

5. Frequent atrial extrasystolic beats predict atrial fibrillation in patients with congenital heart defects

Author

Teuwen, Christophe P., Korevaar, Tim I.M., Coolen, Rosa L., Wel, Twan van der, Houck, Charlotte A., Evertz, R., Yaksh, A., Bogers, Ad J.J.C., Groot, Natasja M.S. de, Teuwen, Christophe P., Korevaar, Tim I.M., Coolen, Rosa L., Wel, Twan van der, Houck, Charlotte A., Evertz, R., Yaksh, A., Bogers, Ad J.J.C., and Groot, Natasja M.S. de

Abstract

Item does not contain fulltext

Published
2018

6. Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474

Author

van Esbroeck, ACM, Janssen, APA, Cognetta, AB, Ogasawara, D, Shpak, Guy, Kroeg, Mark, Kantae, V, Baggelaar, MP, de Vrij, Femke, Deng, H, Allara, M, Fezza, F, Lin, Zhanmin, Wel, Twan, Soethoudt, M, Mock, ED, den Dulk, H, Baak, IL, Florea, BI, Hendriks, G, de Petrocellis, L, Overkleeft, HS, Hankemeier, T, de Zeeuw, Chris, Di Marzo, V, Maccarrone, M, Cravatt, BF, Kushner, Steven, van der Stelt, M, van Esbroeck, ACM, Janssen, APA, Cognetta, AB, Ogasawara, D, Shpak, Guy, Kroeg, Mark, Kantae, V, Baggelaar, MP, de Vrij, Femke, Deng, H, Allara, M, Fezza, F, Lin, Zhanmin, Wel, Twan, Soethoudt, M, Mock, ED, den Dulk, H, Baak, IL, Florea, BI, Hendriks, G, de Petrocellis, L, Overkleeft, HS, Hankemeier, T, de Zeeuw, Chris, Di Marzo, V, Maccarrone, M, Cravatt, BF, Kushner, Steven, and van der Stelt, M

Published
2017

9. [A man with abdominal bloating].

Author

van der Wel T, van Dijk LJD, and de Vries AC

Subjects
Aged, Humans, Male, Tomography, X-Ray Computed, Aortic Aneurysm, Abdominal complications, Duodenal Obstruction diagnostic imaging, Duodenal Obstruction etiology
Abstract

A 73-year-old man with an aneurysm of the abdominal aorta (AAA) presented with abdominal bloating. CT-angiography showed compression of the duodenum between the AAA and the pancreas and superior mesenteric artery with dilatation of the descending duodenum, leading to the diagnosis of mechanical duodenal obstruction due to compression by an AAA.

Published
2018

10. Frequent atrial extrasystolic beats predict atrial fibrillation in patients with congenital heart defects.

Author

Teuwen CP, Korevaar TIM, Coolen RL, van der Wel T, Houck CA, Evertz R, Yaksh A, Roos-Hesselink JW, Bogers AJJC, and de Groot NMS

Subjects
Action Potentials, Adult, Atrial Fibrillation diagnosis, Atrial Fibrillation physiopathology, Atrial Premature Complexes diagnosis, Atrial Premature Complexes physiopathology, Electrocardiography, Ambulatory, Female, Heart Defects, Congenital diagnosis, Heart Defects, Congenital physiopathology, Humans, Incidence, Male, Middle Aged, Netherlands epidemiology, Predictive Value of Tests, Retrospective Studies, Risk Assessment, Risk Factors, Young Adult, Atrial Fibrillation epidemiology, Atrial Premature Complexes epidemiology, Heart Conduction System physiopathology, Heart Defects, Congenital epidemiology, Heart Rate
Abstract

Aims: Atrial fibrillation (AF) is increasingly observed in patients with congenital heart defects (CHDs) who survive nowadays into adulthood. Yet, predictors of AF are scarce in this high-risk population. This study therefore examined the predictive ability of atrial extrasystole (AES) for development of AF in CHD patients., Methods and Results: Adult CHD patients who had a 24 h Holter registration were followed to determine who developed AF. A total of 573 patients (49% male, mean age 35 ± 12 years) were included; they had a simple/complete repaired CHD (n = 279), complex repaired CHD (n = 251), or univentricular heart (UVH, n = 43). Ageing (P < 0.0001), female gender (P = 0.028), UVH (P = 0.0010), and left atrial dilatation (P = 0.0025) were associated with the number of AES. During a median follow-up of 51.6 months (interquartile range 22.8-85.7), 29 patients (5%) developed de novo AF. An one-point increase in the number of logtotal-AES was associated with a two-fold higher risk of AF development (hazard ratio 1.95; 95% confidence interval 1.21-3.13; P = 0.016). C-statistic for left atrial dilatation, complexity, and age had a good discriminative ability for the incidence of AF with a C-statistic of 84.5%. The addition of the total number of AES/24 h to this model increased C-statistic to 88.4%., Conclusion: Atrial extrasystole occur relatively frequent in adult CHD patients compared with patients with other cardiac diseases. This is the first study that showed an association between an increased AES frequency and a higher risk of AF development in CHD patients., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For permissions please email: journals.permissions@oup.com.)

Published
2018
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