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PurposeThis study explores the impact mechanism of corporate digital transformation (CDT) on the quality of accounting information.Design/methodology/approachSamples of A-share listed companies on the Shanghai and Shenzhen stock exchanges from 2007 to 2020 are used as a research sample. The empirical analysis is based on the ordinary least squares regression model, and mediation and moderation effect models were used in further analysis.FindingsThis study finds that CDT enhances accounting information quality by alleviating the agency problem. This positive effect is more significant among firms that exhibit less media coverage, have low industry competition and are not subject to cyber-attack.Originality/valueThis study extends the economic consequences of CDT and enriches the literature on the factors that affect accounting information quality. Further, this study's findings guide the government to actively promote CDT, facilitate the digital upgrading of industries and improve accounting information quality and efficiency in capital markets.

OBJECTIVE: To evaluate the efficacy of 3D printed nasal vestibular support on the recovery of nasal ventilation function and nostril shape after nostril stenosis treatment. METHODS: Thirty-eight patients with unilateral traumatic nasal vestibular stenosis were selected and treated with 3D printed nasal vestibular support after operation. Subjective evaluation indicators, objective nostril local morphological and structural parameters, and nasal airflow dynamics parameters by numerical simulation were used. To evaluate the nostril morphological and nasal functional recovery after treatment. RESULTS: The subjective nasal congestion and nostril symmetry satisfaction VAS scores of the patients after nasal vestibular support treatment were improved to varying degrees compared with those before surgery; The nostril morphological parameters showed that the Δ(long-axis ratio) and Δ (short-axis ratio) were significantly decreased after nasal vestibular support therapy (0.09±0.09 and 0.16±0.13) compared with those before surgery(0.21±0.20 and 0.28±0.21) respectively(P < 0.01). And the cross-sectional area of the nasal valve on the stenotic side nasal cavity increased from(0.40±0.27) cm(2) before operation to (0.71±0.26) cm(2) after treatment(P < 0.01); The nasal resistance on the stenosis side nasal cavity also decreased from (0.036±0.024) Pa·s/mL before operation to (0.022±0.008) Pa. s/mL after treatment(P < 0.01), and the total nasal resistance was decreased from (0.033±0.02) Pas/mL before operation to (0.021±0.007)Pa. s/mL after treatment(P < 0.01); It also showed that NWE(nasal warming efficiency) and NHE(nasal humidification efficiency) on the stenotic side nasal cavity were significantly decreased after nasal vestibular support therapy([95.92±2.8]% and [94.55±4.17]%) compared with those before surgery ([97.94±1.97]% and [96.19±2.94]%) respectively(P < 0.01). CONCLUSION: The 3D printed nasal vestibular support for postoperative support treatment on patients with anterior nostril stenosis can reflect the advantages of personalized treatment and allow patients to obtain satisfactory results, and the use of individually designed 3D printed nasal vestibular support can make the shape of anterior nostrils and nasal cavity normal ventilation function recover well, its clinical application prospect is worth looking forward to.

Allergic rhinitis (AR) is a common chronic disease characterized by inflammation of the nasal mucosa. Long non-coding RNA (LncRNA) has been reported to be involved in the pathogenesis of various diseases. However, the biological roles of lncRNA Nuclear Paraspeckle Assembly Transcript 1 (NEAT1) in AR are still unclear. The mRNA levels of NEAT1, miR-511, and Nuclear Receptor Subfamily 4 Group A Member 2 (NR4A2) were detected by RT-qPCR. The protein levels of exosomal markers were examined by western blot. ELISA was used to assess the levels of GM-CSF, eotaxin-1, and MUC5AC. The cell viability and apoptosis were evaluated by CCK-8 and TUNEL assays. In this study, we found that the NEAT1 level was highly expressed in AR and IL-13-treated HNECs. NEAT1 interference significantly suppressed levels of GM-CSF, eotaxin-1, and MUC5AC and apoptosis rate, but promoted the viability of IL-13-treated human nasal epithelial cells (HNECs). Moreover, exosomes containing NEAT1 induced inflammatory cytokine production and apoptosis, while NEAT1 depletion abrogated these effects. In addition, NEAT1 directly interacted with miR-511, and the inhibition of miR-511 partially restored the inhibitory effects of NEAT1 silencing on inflammatory cytokine, mucus production, and apoptosis in IL-13-stimulated HNECs. Furthermore, miR-511 could bind to the 3ʹUTR of NR4A2, and the inhibition of miR-511 increased levels of inflammatory factors and apoptosis rate, which was counteracted by depleting NR4A2. In conclusion, our data revealed that exosomal NEAT1 contributed to the pathogenesis of AR through the miR-511/NR4A2 axis. These findings might offer novel strategies for the prevention and treatment of AR.

Objective Setup computational fluid dynamics (CFD) model of the nasal cavity in patients with Crouzon syndrome analyze inspiratory airflow hydrokinetics of its nasal cavity. After changing the morphosis structure of the nasal cavity by operation, compare the preoperative and postoperative alteration of the airflow field of the nasal cavity and evaluate the effect of operation on the physiological function of nasal ventilation. Methods Eleven patients with Crouzon syndrome were underwent spiral computed tomographic laminar scanning to obtain DICOM data and establish the CFD model. The field features of the nasal cavity with inspiratory static state phase were simulated and analyzed by the Fluent software. The changed data on preoperative and postoperative flow field in the nasal cavity in 5 of 11 patients were compared and analyzed. Results The nasal cavity of a patient with Crouzon syndrome reflected the structural features of relatively short and high-vaulted anteroposterior diameter. The nasal valve was the narrowest region in the nasal cavity and was the key region of producing obvious pressure drop. The inspiratory static state phase reflected comparatively high local airflow rate (approximately 2.469 m/s) and sheer force of the nasal wall. With the distance increasing from the anterior naris, the pressure inside the nasal cavity was decreased gradually. The pressure drop in the nasal cavity before the front end of the concha nasalis inferior (approximately 2 cm from anterior naris) accounted for most of the pressure of the whole nasal cavity (69%-88% of the overall pressure in nasal cavity and 79.24% on average). Osteotomy advancement and distraction osteogenesis increased the anteroposterior diameter of the nasal cavity and the changed nasal resistance. Conclusions By analyzing the structure of the nasal cavity of patients with Crouzon syndrome and the CFD numerical simulation of patients after the procedure, airflow distribution in patients' nasal cavity and the effect of the surgery on the structure of the nasal cavity and airflow field were realized. Nasal valve played a pivotal role in the airflow field distribution of the nasal cavity. Operation changed the nasal resistance, improved the ventilation of nasal cavity, but did not affect the airflow field distribution of nasal cavity.