99 results on '"Weissler AM"'
Search Results
2. Traditional risk factors for coronary heart disease.
- Author
-
Rockhill B, Root M, Cobb F, Weissler AM, Khot UN, Khot MB, Topol EJ, Greenland P, and Weissler, Arnold M
- Published
- 2004
- Full Text
- View/download PDF
3. Effect of digitalis on systolic time intervals in heart failure
- Author
-
Weissler Am and Schoenfeld Cd
- Subjects
Male ,medicine.medical_specialty ,Hemodynamics ,Digitalis ,Blood Pressure ,Heart Rate ,Internal medicine ,Medicine ,Humans ,In patient ,Cardiac Output ,Lanatosides ,Heart Failure ,Ejection fraction ,biology ,business.industry ,Digitalis Glycosides ,General Medicine ,Arteries ,biology.organism_classification ,medicine.disease ,Systolic time intervals ,Heart failure ,Cardiology ,Female ,Vascular Resistance ,business ,Heart Auscultation - Abstract
It is generally recognized that conventional hemodynamic measures are not consistently altered by digitalis in patients with congestive heart failure. In normal subjects. digitalis has been found to abbreviate the systolic time intervals at a time when other hemodynamic changes are minimal.
- Published
- 1970
4. Studies on fat mobilization during acute states of arousal
- Author
-
Bogdonoff, Estes Eh, and Weissler Am
- Subjects
medicine.medical_specialty ,Mobilization ,business.industry ,Mental Disorders ,General Medicine ,Arousal ,Fats ,Endocrinology ,Stress, Physiological ,Internal medicine ,medicine ,Humans ,business ,Physical Therapy Modalities - Published
- 1960
5. Measurements of regional and global left ventricular function have independent prognostic value in patients with prior myocardial infarction
- Author
-
Miller, TD, Weissler, AM, Christian, TF, Bailey, KR, and Gibbons, RJ
- Published
- 1995
- Full Text
- View/download PDF
6. A critique on contemporary reporting of likelihood ratios in test power analysis.
- Author
-
Weissler AM and Bailey KR
- Subjects
- False Negative Reactions, False Positive Reactions, Humans, Predictive Value of Tests, Reproducibility of Results, Likelihood Functions, Sensitivity and Specificity
- Published
- 2004
- Full Text
- View/download PDF
7. Traditional risk factors for coronary heart disease.
- Author
-
Weissler AM
- Subjects
- Humans, Risk Factors, Coronary Disease epidemiology
- Published
- 2004
- Full Text
- View/download PDF
8. Pathophysiologic determinants of third heart sounds: a prospective clinical and Doppler echocardiographic study.
- Author
-
Tribouilloy CM, Enriquez-Sarano M, Mohty D, Horn RA, Bailey KR, Seward JB, Weissler AM, and Tajik AJ
- Subjects
- Aged, Aortic Valve Insufficiency diagnostic imaging, Blood Flow Velocity, Blood Pressure, Diagnosis, Differential, Diastole, Female, Heart Murmurs diagnostic imaging, Heart Rate, Humans, Male, Middle Aged, Mitral Valve Insufficiency diagnostic imaging, Observer Variation, Predictive Value of Tests, Prospective Studies, Pulmonary Wedge Pressure, Stroke Volume, Systole, Ventricular Dysfunction, Left diagnostic imaging, Aortic Valve Insufficiency physiopathology, Echocardiography, Doppler, Heart Murmurs physiopathology, Mitral Valve Insufficiency physiopathology, Ventricular Dysfunction, Left physiopathology
- Abstract
Purpose: We sought to determine the importance of a third heart sound (S(3)) and its relation to hemodynamic and valvular dysfunction., Subjects and Methods: We prospectively enrolled 580 patients who had isolated valvular regurgitation (mitral, n = 299; aortic, n = 121) or primary left ventricular dysfunction with or without functional mitral regurgitation (n = 160). We analyzed the associations between the clinical finding of an audible S(3) (as noted in routine clinical practice by internal medicine physicians) and hemodynamic alterations measured by comprehensive quantitative Doppler echocardiography., Results: S(3) was more prevalent in patients with primary left ventricular dysfunction (46%, n = 73) than in organic mitral (16%, n = 47) or aortic (12%, n = 14) regurgitation (P <0.001). Patients with an S(3) were more likely to have class III-IV symptoms (55% [74 of 137] vs. 18% [80 of 443] of those without an S(3), P <0.001) and had a higher mean [+/- SD] pulmonary pressure (55 +/- 15 vs. 41 +/- 11 mm Hg, P <0.001). An S(3) was also related to a higher early filling velocity due to a greater filling volume, restrictive filling, or both. An S(3) was a marker of severe regurgitation (regurgitant fraction > or =40%) in patients with primary left ventricular dysfunction (odds ratio [OR] = 2.4; 95% confidence interval [CI]: 1.1 to 5.5), mitral regurgitation (OR = 17; 95% CI: 5.8 to 52), and aortic regurgitation (OR = 7.1; 95% CI: 1.8-28). An S(3) was also associated with restrictive filling in primary left ventricular dysfunction (OR = 3.0; 95% CI, 1.6 to 5.9), marked dilatation in mitral regurgitation (OR = 20; 95% CI: 6.8 to 58), and an ejection fraction (<50%) in aortic regurgitation (OR = 19; 95% CI: 6.0 to 62)., Conclusion: An audible S(3) is an important clinical finding, indicating severe hemodynamic alterations, and should lead to a comprehensive assessment and consideration of vigorous medical or surgical treatment.
- Published
- 2001
- Full Text
- View/download PDF
9. Diagnostic marker cooperative study for the diagnosis of myocardial infarction.
- Author
-
Weissler AM
- Subjects
- Biomarkers blood, Clinical Trials as Topic, Creatine Kinase blood, Humans, Isoenzymes, Multicenter Studies as Topic, Myocardial Infarction blood, Myoglobin blood, Sensitivity and Specificity, Troponin I blood, Troponin T blood, Myocardial Infarction diagnosis
- Published
- 2000
- Full Text
- View/download PDF
10. A perspective on standardizing the predictive power of noninvasive cardiovascular tests by likelihood ratio computation: 2. Clinical applications.
- Author
-
Weissler AM
- Subjects
- Adrenergic beta-Agonists, Bias, Cardiotonic Agents, Confounding Factors, Epidemiologic, Coronary Angiography, Coronary Disease diagnostic imaging, Coronary Disease physiopathology, Diagnosis, Differential, Dobutamine, Echocardiography, Electrocardiography, Exercise Test, False Positive Reactions, Female, Humans, Male, Mathematics, Middle Aged, ROC Curve, Radionuclide Imaging, Risk Factors, Coronary Disease diagnosis, Odds Ratio, Predictive Value of Tests, Risk
- Abstract
Likelihood ratio measures may be used as a standard for expressing the predictive power of noninvasive cardiovascular tests, calculated from sensitivity and specificity measures or as ratios of the predictive value odds to pretest odds for positive and negative test results. The positive likelihood ratio, (+)LR, expresses the power of a positive test result to augment an estimate of disease probability independent of the pretest prevalence of disease in a given population; the negative likelihood ratio, (-)LR, expresses the power of a negative test result to augment an estimate of the probability of no disease independent of the pretest prevalence of no disease in the same population. The likelihood ratio principle is applicable to the evaluation of the predictive power of single or combined test results reported for either dichotomous or continuous end points. This part of the perspective exemplifies application of the likelihood ratio principle in a wide variety of testing conditions for coronary artery disease followed by a discussion of the limitations of likelihood ratio computation in test power evaluation. Likelihood ratios provide a more concise and unambiguous standard for calibrating the predictive power of single and combined noninvasive cardiovascular test results than are provided by measures of sensitivity, specificity, and predictive value.
- Published
- 1999
- Full Text
- View/download PDF
11. A perspective on standardizing the predictive power of noninvasive cardiovascular tests by likelihood ratio computation: 1. Mathematical principles.
- Author
-
Weissler AM
- Subjects
- Confidence Intervals, Confounding Factors, Epidemiologic, Coronary Disease epidemiology, Electrocardiography, Exercise Test, Humans, Prevalence, Sensitivity and Specificity, Coronary Disease diagnosis, Mathematics, Odds Ratio, Predictive Value of Tests
- Abstract
The current practice of reporting positive and negative predictive value (PV), sensitivity (Se), and specificity (Sp) as measures of the power of noninvasive cardiovascular tests has significant limitations. A test result's PV and its comparison with other test results are highly dependent on the pretest disease prevalence at which it is determined; the citation of sensitivity and specificity provides no succinct or explicit quantitation of the rule-in and rule-out power of a test. This article presents a rationale for the use of an alternative standard for expressing predictive power in the form of positive and negative likelihood ratios, (+)LR and (-)LR. The likelihood ratios are composite expressions of test power, which incorporate the Se and Sp and their respective complements [(1 - Se) and (1 - Sp)], thus yielding single unambiguous measures of positive and negative predictive power. The likelihood ratios are calculated as follows: (+)LR = Se/(1 - Sp) and (-)LR = Sp/(1 - Se). On analysis of the predictive value equations, the likelihood ratios equal the quotients of the posttest predictive value odds to the pretest prevalence odds for disease and no disease, respectively, as follows: (+)LR = (+)PVOd/POD and (-)LR = (-)PVOn/PON, where (+)PVOd is positive predictive value odds for disease, POD is prevalence odds for disease, (-)PVOn is negative predictive value odds for no disease, and PON is prevalence odds for no disease. Thus, the likelihood ratios are measures of the odds advantage in posttest probability of disease or no disease relative to pretest probability, independent of disease prevalence in the tested population. The quotients of the (+)LR or the (-)LR among test results studied in a common population are direct expressions of their relative predictive power in that population. The likelihood ratio principle is applicable to the evaluation of the predictive power of multiple tests performed in a common population and to estimating predictive power at multiple test thresholds.
- Published
- 1999
- Full Text
- View/download PDF
12. Hypertrophic cardiomyopathy with obstruction: important diagnostic clue provided by the direction of the mitral regurgitation jet.
- Author
-
Yeo TC, Miller FA Jr, Oh JK, Schaff HV, Weissler AM, and Seward JB
- Subjects
- Echocardiography, Doppler, Color, Echocardiography, Transesophageal, Female, Humans, Middle Aged, Mitral Valve diagnostic imaging, Mitral Valve Insufficiency complications, Mitral Valve Insufficiency surgery, Cardiomyopathy, Hypertrophic complications, Mitral Valve Insufficiency diagnostic imaging
- Abstract
We present an unusual case of hypertrophic cardiomyopathy complicated by mitral regurgitation resulting from chordal rupture with flail posterior mitral leaflet. The diagnosis was suggested by the presence of an anteriorly directed mitral regurgitation jet on transthoracic color flow imaging, in addition to the typical posterolateral-lateral jet caused by systolic anterior mitral motion. The flail posterior leaflet was confirmed by transesophageal echocardiography, and the patient underwent mitral valve repair in addition to myectomy. This combination of hypertrophic cardiomyopathy and flail mitral leaflet usually requires surgical intervention, and prompt diagnosis is important. The presence of an anteriorly directed mitral regurgitant jet should always raise suspicion of posterior mitral leaflet abnormality.
- Published
- 1998
- Full Text
- View/download PDF
13. Quantitative measures of regional asynergy add independent prognostic information to left ventricular ejection fraction in patients with prior myocardial infarction.
- Author
-
Miller TD, Weissler AM, Christian TF, Bailey KR, and Gibbons RJ
- Subjects
- Analysis of Variance, Cardiac Output, Low diagnostic imaging, Cardiac Output, Low physiopathology, Coronary Disease diagnostic imaging, Coronary Disease physiopathology, Electrocardiography, Female, Follow-Up Studies, Gated Blood-Pool Imaging, Humans, Male, Middle Aged, Myocardial Contraction, Myocardial Infarction diagnostic imaging, Prognosis, Proportional Hazards Models, Regression Analysis, Retrospective Studies, Single-Blind Method, Survival Rate, Ventricular Dysfunction, Left diagnostic imaging, Myocardial Infarction physiopathology, Stroke Volume, Ventricular Dysfunction, Left physiopathology, Ventricular Function, Left
- Abstract
The purpose of this study was to determine if quantitative measurements of regional asynergy add independent prognostic information to global ejection fraction in patients with chronic coronary artery disease. Four hundred eighty-six patients with a history of Q-wave myocardial infarction who underwent gated-equilibrium radionuclide angiography at least 3 months after infarction were monitored for a median duration of 4.7 years. During follow-up there were 95 deaths. Four of five regional asynergy indexes analyzed were associated with overall mortality. The strength of the association between overall mortality and the index that proved to be optimal (univariate chi2 = 26.4, p < 0.001) was stronger than for global ejection fraction (univariate chi2 = 21.5, p < 0.001). For patients with global ejection fraction <40%, 4-year survival was 87% for those with a low asynergy index versus 65% for those with a high asynergy index (p = 0.016). In conclusion, indexes of regional asynergy add independent prognostic information to global left ventricular ejection fraction.
- Published
- 1997
- Full Text
- View/download PDF
14. The Hippocratic ethic in a contemporary era of clinical uncertainty.
- Author
-
Weissler AM
- Subjects
- Greece, Ancient, History, Ancient, Hippocratic Oath, Uncertainty
- Published
- 1991
- Full Text
- View/download PDF
15. Estimation of the risk of death after acute myocardial infarction from systolic time intervals.
- Author
-
Weissler AM
- Subjects
- Humans, Middle Aged, Risk Factors, Systole physiology, Time Factors, Myocardial Infarction mortality
- Published
- 1990
- Full Text
- View/download PDF
16. Augmentation of mortality risk discriminating power of left ventricular ejection fraction by measures of nonuniformity in systolic emptying on radionuclide ventriculography.
- Author
-
Weissler AM, Miller BI, Granger CB, Henry TD, Sheikh KH, Kirch DL, Guess WB, and Krumbach BJ
- Subjects
- Aged, Electrocardiography, Female, Humans, Male, Middle Aged, Models, Cardiovascular, Myocardial Infarction diagnostic imaging, Myocardial Infarction physiopathology, Reproducibility of Results, Risk, Survival Analysis, Myocardial Infarction mortality, Radionuclide Ventriculography, Stroke Volume
- Abstract
Employing equilibrium-gated radionuclide ventriculography in the left anterior oblique view, six geometric models and five mathematic coefficients of nonuniformity in regional left ventricular emptying were tested for their relative mortality risk-stratifying power and capacity to augment the risk-discriminating potency of the continuous and dichotomized global ejection fraction. Radionuclide ventriculography was performed an average of 7.6 days after acute myocardial infarction. All geometric models significantly separated 20 normal subjects from 137 patients with recent infarction (p less than 0.001). Cumulative mortality data demonstrated that significant independent univariate dichotomizing potency and augmentation of the mortality risk-discriminating power of the global ejection fraction were provided by models of regional emptying that 1) conformed to coronary artery perfusion areas, 2) encompassed total ventricular counts, 3) expressed variability in regional relative to global ejection fraction, and 4) simulated a pattern of emptying directed toward the center of geometry of the left ventricle. The combination of a four quadrant geometric model with axes drawn 45 degrees above the horizontal and a coefficient of variation calculated as square root of sigma(GEF - REF)2/4 x 100/GEF (where GEF = global ejection fraction and REF = regional ejection fraction) proved to be optimal. This coefficient averaged 12.2% in normal subjects and 32.2% in patients with recent acute myocardial infarction (p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1990
- Full Text
- View/download PDF
17. Natural history of electrical interventricular septal force in the course of left ventricular hypertrophy in man.
- Author
-
Das G, Collins J, and Weissler AM
- Subjects
- Adult, Aged, Aortic Valve, Cardiomyopathies physiopathology, Coronary Disease physiopathology, Female, Heart Failure physiopathology, Heart Valve Diseases physiopathology, Humans, Male, Middle Aged, Cardiomegaly physiopathology, Electrocardiography, Heart Septum physiopathology, Myocardial Contraction
- Abstract
Initial electrical forces emanating from interventricular septal depolarization, being directed to the right and anteriorly, normally produce an initial negative deflection or Q wave in leads I, aVL and V6 and an initial positive deflection or R wave in leads V1 and V2. The observations of hypertrophied interventricular septum, an integral part of the left ventricle, in patients with left ventricular hypertrophy would predict an increase in these septal electrical forces similar to the total left ventricular (QRS) forces in these subjects. Contrary to this expectation, several studies document an actual decrease or absence of the normally oriented initial forces in ECGs of patients with the criteria of left ventricular hypertrophy. In order to clarify the nature of this paradox, this study was initiated. Our observations suggest that the normal initial septal forces indeed increase as expected, during the initial four to six years, and subsequently show a progressive decline in patients with left ventricular hypertrophy. Although the precise mechanism for the bimodal change in the septal forces during the period of the constancy of the total QRS forces is not clear, a hypothesis based on the current knowledge is advanced to explain these observations.
- Published
- 1981
- Full Text
- View/download PDF
18. Identification of patients with improved survival following coronary bypass surgery.
- Author
-
Boudoulas H, Sohn YH, O'Neill W, Brown R, and Weissler AM
- Subjects
- Actuarial Analysis, Adult, Coronary Disease physiopathology, Coronary Disease surgery, Female, Follow-Up Studies, Humans, Male, Middle Aged, Myocardial Infarction physiopathology, Risk, Stroke Volume, United States, Coronary Artery Bypass, Heart physiopathology, Myocardial Infarction mortality
- Abstract
This study was designed to determine whether left ventricular performance measured noninvasively from the systolic time intervals could identify patients in whom coronary bypass surgery may improve survival. 71 patients with two- or three-vessel disease undergoing coronary bypass surgery were compared with 78 matched medically treated patients. All patients had recuperated from myocardial infarction by a mean of 17.6 months when systolic time intervals were performed. Surgical and medical patients were classified preoperatively into those with normal and those with abnormal left ventricular performance by preejection period/left ventricular ejection time (PEP/LVET less than or equal to 0.42 and greater than 0.42, respectively). Survival was analyzed by life table and log-rank test. Cumulative 5-year survival in patients with normal left ventricular performance was not statistically different in surgical and medical groups (96 vs. 93%, respectively). In contrast, cumulative survival in patients with abnormal left ventricular performance was significantly greater in the surgical group when compared to the medical group (84 vs. 62, p less than 0.01). Among the patients with abnormal left ventricular function, the mean PEP/LVET and the average vessel disease were not different in the medical and surgical groups. Multivariate analysis of 17 other clinical and laboratory risk variables were not different between these two groups. It is concluded that coronary bypass surgery my improve survival in patients with two- or three-vessel disease and left ventricular dysfunction.
- Published
- 1984
- Full Text
- View/download PDF
19. Accuracy of systolic time intervals in detecting abnormal left ventricular performance in coronary artery disease.
- Author
-
Stack RS, Sohn YH, and Weissler AM
- Subjects
- Coronary Disease complications, Humans, Myocardial Infarction complications, Regression Analysis, Time Factors, Coronary Disease physiopathology, Heart Ventricles physiopathology, Myocardial Contraction, Systole
- Published
- 1981
- Full Text
- View/download PDF
20. Value of positive myocardial technetium-99m-pyrophosphate scintigraphy in the noninvasive diagnosis of cardiac amyloidosis.
- Author
-
Wizenberg TA, Muz J, Sohn YH, Samlowski W, and Weissler AM
- Subjects
- Aged, Amyloidosis diagnosis, Amyloidosis physiopathology, Cardiomyopathies diagnosis, Cardiomyopathies physiopathology, Echocardiography, Female, Heart physiopathology, Humans, Male, Middle Aged, Radionuclide Imaging, Systole, Technetium Tc 99m Pyrophosphate, Amyloidosis diagnostic imaging, Cardiomyopathies diagnostic imaging, Diphosphates, Heart diagnostic imaging, Technetium
- Abstract
Ten consecutive patients with tissue-proven amyloidosis, seven of whom presented with congestive heart failure, were found to exhibit intense diffuse uptake of technetium-99m-pyrophosphate (Tc-99m-PYP) on cardiac radionuclide imaging. The patients exhibited echocardiographic and systolic time interval abnormalities suggesting combined restrictive and congestive cardiomyopathic changes. On M-mode echocardiograms, there was symmetrically increased thickness of the interventricular septum and left ventricular (LV) posterior wall in diastole (10 of 10), decreased fractional shortening of the LV minor axis diameter in systole (eight of nine), and decreased percent thickening of the LV minor axis diameter in systole (eight of nine) and LV posterior wall (10 of 10) in systole. Three patients demonstrated enlarged LV end-diastolic diameter. All 10 patients had abnormal PEP/LVET and eight had shortened LVETI. When combined with noninvasive tests of LV performance, positive myocardial pyrophosphate (PYP) scanning provides a new and useful adjunct in the diagnosis of amyloid heart disease.
- Published
- 1982
- Full Text
- View/download PDF
21. Sudden death: detecting the vulnerable ventricle by noninvasive methods.
- Author
-
Weissler AM and Boudoulas H
- Subjects
- Arrhythmias, Cardiac prevention & control, Arterial Occlusive Diseases complications, Community Health Services, Coronary Disease complications, Electrophysiology, Heart Ventricles pathology, Heart Ventricles physiopathology, Humans, Methods, Monitoring, Physiologic, Resuscitation, Ventricular Fibrillation complications, Death, Sudden etiology, Heart Diseases diagnosis
- Published
- 1981
22. Prognosis in coronary artery disease: a noninvasive approach.
- Author
-
Weissler AM
- Subjects
- Humans, Myocardial Infarction mortality, Prognosis, Cardiac Output, Coronary Disease mortality, Stroke Volume
- Published
- 1983
23. Presidential addresses. Academic medical center decompensation: a cardiologist's viewpoint.
- Author
-
Weissler AM
- Subjects
- Angina Pectoris diagnosis, Echocardiography, Economics, Medical, Education, Medical organization & administration, Electrocardiography, Faculty, Health Education, Humans, Patient Care Planning, Research, Syndrome, Heart Failure diagnosis, Wit and Humor as Topic
- Published
- 1983
24. Prognosis in coronary artery disease: a noninvasive approach.
- Author
-
Weissler AM and Boudoulas H
- Subjects
- Coronary Disease diagnosis, Electrocardiography, Humans, Prognosis, Stroke Volume, Systole, Time Factors, Coronary Disease mortality
- Published
- 1984
25. New observations on the effects of atropine on the sinoatrial and atrioventricular nodes in man.
- Author
-
Das G, Talmers FN, and Weissler AM
- Subjects
- Adult, Atropine administration & dosage, Atropine adverse effects, Clinical Trials as Topic, Drug Evaluation, Electrocardiography, Heart Rate drug effects, Humans, Placebos, Arrhythmias, Cardiac chemically induced, Atrioventricular Node drug effects, Atropine pharmacology, Heart Conduction System drug effects, Sinoatrial Node drug effects
- Abstract
Previous observations of slowing of the heart rate after administration of atropine in doses smaller than 0.4 mg and recent reports of development of rhythm disorders in patients with acute myocardial infarction given atropine prompted us to evaluate systematically the effects of various doses of atropine (0.1 to 0.8 mg) on the response of the sinoatrial (S-A) and atrioventricular (A-V) nodes in healthy volunteers. The response of the S-A node to atropine was characteristically bimodal, slowing at smaller doses and accelerating at larger doses. In contrast, the A-V node showed acceleration of conduction in response to all doses of atropine used. A hypothesis based on current understanding of the electrophysiologic parameters governing impulse formation and impulse conduction is advanced to explain the apparent paradox in the S-A and A-V nodal responses to small doses of atropine. The results suggest the need for caution and continuous rhythm monitoring when giving atropine to patients with acute myocardial infarction.
- Published
- 1975
- Full Text
- View/download PDF
26. Common cardiac arrhythmias: recognition and treatment.
- Author
-
Talmers FN, Kinhal V, Sabharwal S, and Weissler AM
- Subjects
- Arrhythmias, Cardiac drug therapy, Arrhythmias, Cardiac etiology, Humans, Arrhythmias, Cardiac diagnosis, Electrocardiography
- Abstract
Cardiac arrhythmias are commonly seen in the everyday practice of medicine by the physician. Although certain arrhythmias may be suspected clinically, precise diagnosis is made by electrocardiographic recording of the abnormal rhythm. Once the arrhythmia has been recorded, the next steps are proper electrocardiographic diagnosis and selection of proper treatment. The specific mode of therapy and the speed with which it is delivered will depend not only on the type of arrhythmia, but also on the hemodynamic consequences of the rhythm abnormality on the patient's cardiovascular system. The purpose of this paper is to discuss the electrocardiographic criteria of common cardiac arrhythmias as well as current concepts regarding therapy.
- Published
- 1981
27. Noninvasive methods for assessing left ventricular performance in man.
- Author
-
Weissler AM
- Subjects
- Ballistocardiography, Echocardiography, Heart Diseases diagnosis, Heart Diseases physiopathology, Heart Ventricles pathology, Hemodynamics, Humans, Kinetocardiography, Kymography, Methods, Plethysmography, Impedance, Radionuclide Imaging, Time Factors, Heart Function Tests, Heart Ventricles physiopathology
- Published
- 1974
- Full Text
- View/download PDF
28. Left ventricular performance in coronary artery disease evaluated with systolic time intervals and echocardiography.
- Author
-
Stack RS, Lee CC, Reddy BP, Taylor ML, and Weissler AM
- Subjects
- Adult, Aged, Coronary Angiography, Female, Humans, Middle Aged, Myocardial Infarction diagnosis, Myocardial Infarction diagnostic imaging, Ventricular Function, Echocardiography, Heart Ventricles physiopathology, Myocardial Infarction physiopathology, Phonocardiography
- Abstract
Simultaneous determinations of systolic time intervals (preejection period index [PEPI], left ventricular ejection time index [LVETI] and ratio of preejection period to left ventricular ejection time [PEP/LVET]) and echographic measures of left ventricular performance (percent change in minor axis diameter [%delta D], circumferential shortening rate [Vcf] and end-diastolic diameter [Dd]) were obtained in 25 normal subjects and 37 patients with previously documented transmural myocardial infarction. The group with previous infarction demonstrated significant (P less than 0.001) differences from the normal group in each of the noninvasive measures. PEP/LVET and %deltaD were the most sensitive measures of left ventricular dysfunction. Deviation from the normal range in these measures occurred, respectively, in 70 and 65 percent of patients without dyspnea or fatigability (20 patients) and 85 percent of those without angina pectoris (13 patients). Abnormalities in systolic time interval and echocardiographic measures were related to the severity of dyspnea and fatigability but not to that of angina. Neither the presence of phonocardiographically documented third or fourth sound gallops nor an abnormal cardiothoracic ratio by chest roentgenogram reliably detected patients with abnormal left ventricular performance. The range of abnormality in left ventricular performance did not differ between patients with prior anterior or diaphragmatic myocardial infarction. The frequency of abnormal performance was greatest among patients with combined sites of prior infarction. Among 26 patients studied by coronary arteriography, abnormal left ventricular performance as determined by values for PEP/LVET and %deltaD occurred in fewer than 30 percent of those with 70 percent or greater obstruction of one coronary artery and in more than 80 percent of those with two or three vessel involvement. There was a high correlation between systolic time intervals, %delta D and Vcf, the closest correlation occurring between PEP/LVET and %deltaD (r = -0.93). These data document the sensitivity of the noninvasive systolic time intervals and echographic measures and their superiority over current clinical bedside methods in evaluating left ventricular performance in patients with prior myocardial infarction.
- Published
- 1976
- Full Text
- View/download PDF
29. Prognostic significance of systolic time intervals after recovery from myocardial infarction.
- Author
-
Weissler AM, O'Neill WW, Sohn YH, Stack RS, Chew PC, and Reed AH
- Subjects
- Angina Pectoris diagnosis, Coronary Disease mortality, Dyspnea diagnosis, Female, Humans, Male, Middle Aged, Myocardial Infarction diagnosis, Myocardial Infarction mortality, Prognosis, Risk, Stroke Volume, Time Factors, Myocardial Contraction, Myocardial Infarction physiopathology, Systole
- Published
- 1981
- Full Text
- View/download PDF
30. Left ventricular mass and systolic performance in chronic systemic hypertension.
- Author
-
Boudoulas H, Mantzouratos D, Sohn YH, and Weissler AM
- Subjects
- Adult, Aged, Cardiomegaly physiopathology, Echocardiography, Female, Humans, Hypertension complications, Male, Middle Aged, Stroke Volume, Cardiomegaly etiology, Heart physiopathology, Hypertension physiopathology, Myocardial Contraction
- Abstract
This study was undertaken to define the relation between the extent of left ventricular (LV) hypertrophy and ventricular systolic performance in patients with chronic systemic hypertension. Ninety patients with chronic systemic hypertension were compared with 41 normal subjects as determined by angiography. LV mass was estimated from the M-mode echocardiogram. Patients were separated into 3 groups: those with LV mass of less than 2 (group I, n = 58), 2 to 4 (group II, n = 21) and more than 4 (group III, n = 11) standard deviations above mean normal. The ratio of preejection period to LV ejection time (PEP/LVET), percent shortening of the echocardiographic internal diameter (% delta D) and velocity of circumferential shortening (Vcf) were used as indexes of LV systolic performance. The frequency of abnormality, expressed as percent of patients in groups I, II and III, was 33%, 55% and 85% for PEP/LVET, 15%, 35% and 72% for % delta D, and 0%, 15% and 55% for Vcf. For each group PEP/LVET was the most frequently abnormal measure and Vcf was the least frequent abnormality. Calculation of peak and end-systolic wall stress was used as an index of the adequacy of LV hypertrophy. This index was significantly reduced in group I, did not differ from control in group II and was significantly increased in group III, indicating that hypertrophy was appropriate to wall tension in groups I and II. It is concluded that the occurrence of LV dysfunction with increasing LV mass in patients with moderate LV hypertrophy (group I and II) reflects a deficiency in intrinsic contractile performance of the hypertrophied myocardium.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1986
- Full Text
- View/download PDF
31. Comparative pharmacodynamics of betamethyl digoxin and digoxin in man.
- Author
-
Das GP, Talmers RN, and Weissler AM
- Subjects
- Administration, Oral, Adult, Humans, Injections, Intravenous, Stimulation, Chemical, Digoxin analogs & derivatives, Digoxin pharmacology, Glycosides blood, Myocardial Contraction drug effects
- Abstract
The positive inotropic effects and serum glycoside levels following intravenous and oral administration of betamethyl digoxin (BMD) were measured and compared with those of digoxin in normal adults. The cardiac inotropy was assessed noninvasively in the abbreviation of the electromechanical systolic index (QS2I) obtained by serial measurements of systolic time intervals. Following 0.8 mg BMD intravenously, the QS2I abbreviation occurred within 3 min and reached a maximum at 4 hr. The time-course and the magnitude of the response were essentially the same as those obtained with 0.8 mg digoxin given intravenously in the same subjects. The serum glycoside levels were also similar for both drugs. When administered orally the QS2I abbreviation to 0.8 mg BMD appeared at 40 min and reached a maximum at 4 hr. The time-course and the magnitude of the effects were similar to those observed following oral digoxin. The blood digitalis levels following the drug ingestion, however, were significantly higher for BMD than for digoxin which suggests greater gastrointestinal absorption of BMD. Based on our observations, the inotropic effects of BMD are similar to those of digoxin. Our results, however, do not demonstrate greater cardiac activity after oral administration of BMD despite higher blood levels.
- Published
- 1977
- Full Text
- View/download PDF
32. Echocardiographic manifestations of ruptured aortic valvular leaflets in the absence of valvular vegetations.
- Author
-
Das G, Lee CC, and Weissler AM
- Subjects
- Adult, Aged, Aortic Valve Insufficiency surgery, Endocarditis, Bacterial complications, Heart Valve Prosthesis, Humans, Male, Mitral Valve, Rupture, Spontaneous, Aortic Valve Insufficiency diagnosis, Echocardiography
- Abstract
The diagnosis of ruptured (perforated or torn) aortic valvular leaflets due to various causes has been made primarily at surgery or postmortem examination. Although angiocardiographic studies readily reveal aortic regurgitation, they rarely establish the presence of a ruptured aortic cusp as the cause of the aortic leak. Recent echocardiographic experience has brought to our attention seven patients with ruptured aortic valvular leaflets in whom the absenc of valvular vegetations was confirmed at surgery in six and at autopsy in one. The echocardiogram of the aortic root in these subjects revealed little or no increment in the diameter of the aortic root. In systole the usual box-like configuration of the leaflets, similar to that observed in normal subjects, was seen; however, in diastole the normal thin midaortic linear echoes were replaced by a thick band of echoes which often revealed high-frequency oscillations. In addition, high-frequency fibrations of the anterior mitral leaflet in diastole and increased systolic excursion of the interventricular septum and left ventricular posterior wall were observed.
- Published
- 1977
- Full Text
- View/download PDF
33. The clinical diagnosis of syncope.
- Author
-
Boudoulas H, Weissler AM, Lewis RP, and Warren JV
- Subjects
- Adult, Arrhythmias, Cardiac complications, Blood Pressure, Child, Female, Heart Diseases complications, Humans, Male, Stress, Physiological complications, Syncope etiology, Syncope physiopathology, Vascular Diseases complications, Syncope diagnosis
- Published
- 1982
34. Current concepts in cardiology. Systolic-time intervals.
- Author
-
Weissler AM
- Subjects
- Cardiac Catheterization, Cardiac Output, Electrocardiography, Heart Diseases diagnosis, Humans, Kinetocardiography, Methods, Myocardial Infarction diagnosis, Phonocardiography, Time Factors, Myocardial Contraction
- Published
- 1977
- Full Text
- View/download PDF
35. The QT greater than QS2 syndrome: a new mortality risk indicator in coronary artery disease.
- Author
-
Boudoulas H, Sohn YH, O'Neill W, Brown R, and Weissler AM
- Subjects
- Aged, Cineangiography, Coronary Angiography, Coronary Disease mortality, Female, Follow-Up Studies, Heart Rate, Humans, Male, Middle Aged, Myocardial Infarction physiopathology, Prognosis, Risk, Stroke Volume, Coronary Disease physiopathology, Electrocardiography
- Abstract
In the normal population the duration of electrical systole (QT) is shorter (mean -26 +/- 13 ms, 1 standard deviation) than that of electromechanical systole (QS2), which it closely parallels throughout the range of resting heart rate. This close association prompted the hypothesis that the duration of QT may be more closely linked physiologically to QS2 than to the heart rate and hence may provide a more potent prognostic indicator than the relation of QT to heart rate. The present study was designed to test this hypothesis. On hundred stable patients 14 months after myocardial infarction were followed up an average of 43 months. Twenty patients had prolongation of QT relative to QS2 (QT greater than QS2) and 13 patients had long QT corrected for heart rate (QTc). There were 20 deaths (16 sudden). The cumulative 5 year survival rate was 35% in patients with QT greater than QS2 and 91% in patients with QT greater than or equal to QS2 (p less than 0.001). There was no significant difference in survival in patients with long QTc compared with patients with normal QTc (69 versus 82%). Univariate and multivariate analysis for the association of QT greater than QS2 with known risk factors, clinical descriptors, drug therapy, systolic time intervals (preejection period/left ventricular ejection time), and frequency of 1, 2 and 3 vessel coronary occlusive artery disease revealed that only the presence of abnormal preejection period/left ventricular ejection time added significantly to the presence of QT greater than QS2 in stratifying 5-year survival into high and low risk groups. Thus, in patients with coronary artery disease, the presence of QT greater than QS2 provides a new risk indicator that is more potent than QT corrected for heart rate.
- Published
- 1982
- Full Text
- View/download PDF
36. Prognosis in coronary artery disease: a non-invasive perspective.
- Author
-
Weissler AM
- Subjects
- Coronary Disease physiopathology, Heart Ventricles physiopathology, Humans, Prognosis, Coronary Disease mortality
- Published
- 1984
37. Study of the phases of cardiac cycle.
- Author
-
Weissler AM
- Subjects
- Heart Function Tests, Hemodynamics, Humans, Plethysmography, Impedance, Ventricular Function, Heart Diseases physiopathology, Heart Ventricles physiopathology
- Published
- 1977
38. The systolic time intervals and risk stratification after acute myocardial infarction.
- Author
-
Weissler AM
- Subjects
- Humans, Myocardial Infarction drug therapy, Prognosis, Risk, Stroke Volume, Timolol therapeutic use, Myocardial Contraction, Myocardial Infarction mortality
- Published
- 1987
- Full Text
- View/download PDF
39. Changes in diastolic time with various pharmacologic agents: implication for myocardial perfusion.
- Author
-
Boudoulas H, Rittgers SE, Lewis RP, Leier CV, and Weissler AM
- Subjects
- Administration, Oral, Adolescent, Adult, Clinical Trials as Topic, Deslanoside administration & dosage, Deslanoside pharmacology, Dobutamine administration & dosage, Dobutamine pharmacology, Heart Rate drug effects, Humans, Infusions, Parenteral, Injections, Intravenous, Isoproterenol administration & dosage, Isoproterenol pharmacology, Lidocaine administration & dosage, Lidocaine pharmacology, Male, Propranolol administration & dosage, Propranolol pharmacology, Time Factors, Cardiovascular Agents pharmacology, Coronary Circulation, Diastole drug effects, Myocardial Contraction drug effects
- Abstract
Diastolic time (DT) is calculated as the cycle length (RR) minus electromechanical systole (QS2). The ratio of DT (RR-QS2) to RR interval times 100, or the percent diastole (%D), varies nonlinearly with heart rate (HR), increasing rapidly with decreasing HR. The effect of commonly used cardioactive agents on %D was studied in five groups of normal subjects. In group 1 (n = 12), propranolol (160 mg daily) increased %D from 55.9 +/- 1.7 to 64.7 +/- 1.3 (p less than 0.001) by slowing HR. In group 2 (n = 12), dobutamine (2.5 micrograms/kg/min) increased %D from 56.4 +/- 1.4 to 61.8 +/- 1.3 (p less than 0.005) by shortening the QS2. In group 3 (n = 10), Cedilanid-D (1.6 mg i.v.) increased %D from 55.5 +/- 1 to 63.2 +/- 0.7 (p less than 0.001), both by slowing the HR and shortening the QS2. In group 4 (n = 12), isoproterenol (2 micrograms/min) increased HR and shortened the QS2 significantly. The net result was a significant reduction of %D from 56.1 +/- 1.4 to 53.5 +/- 1.1, (p less than 0.05). In group 5 (n = 15), a 100-mg bolus of i.v. lidocaine did not have a significant effect on %D. This study indicates that cardiovascular drugs may have significant effects on the relative duration of diastole either by affecting HR or the duration of systole. This may have clinical implications for patients with coronary artery disease and patients with left ventricular hypertrophy, since in both cases coronary flow in mostly diastolic.
- Published
- 1979
- Full Text
- View/download PDF
40. Left ventricular performance in coronary artery disease by systolic time intervals and echocardiography.
- Author
-
Weissler AM, Stack RS, Lee CC, Reddy BP, and Taylor ML
- Subjects
- Heart Ventricles physiopathology, Humans, Time Factors, Echocardiography, Heart physiopathology, Myocardial Contraction, Myocardial Infarction physiopathology
- Abstract
Determinations of systolic time intervals and echocardiographic measures of left ventricular performance were made in twenty-five normal subjects and 37 patients who had convalesced from a previous transmural myocardial infarction. On group analysis the patients with previous myocardial infarction demonstrated significant differences from the normals in each of the noninvasive measures. Among the noninvasive measures the PEP/LVET and deltaD% proved to be the most sensitive indicators of left ventricular dysfunction. Deviations from the normal range in PEP/LVET and deltaD% occurred in 65% to 70% of patients asymptomatic for dyspnea and fatigability (20 patients) and in 85% of patients asymptomatic for angina pectoris (13 patients). Neither the presence of phonocardiographically documented S3 or S4 or the finding of an abnormal C/T ratio on standard chest x-ray reliably detected patients with abnormal left ventricular performance. Among 26 patients studied by coronary arteriography, abnormal left ventricular performance by PEP/LVET and deltaD% occurred in less than 30% of those with obstruction (70% or greater) of one coronary artery and in over 80% of those with obstruction of two or three major arteries. A close correlation existed between the level of left ventricular performance measured by the PEP/LVET and the deltaD% (r = 0.93). These studies document the high degree of sensitivity of the noninvasive measures and demonstrate their superiority over clinical methods for detecting abnormal left ventricular performance in patients with previous myocardial infarction.
- Published
- 1976
41. Left ventricular performance in mitral regurgitation assessed with systolic time intervals and echocardiography.
- Author
-
Wanderman KL, Goldberg MJ, Stack RS, and Weissler AM
- Subjects
- Adolescent, Adult, Aged, Cardiac Catheterization, Electrocardiography, Female, Heart Ventricles physiopathology, Humans, Male, Middle Aged, Phonocardiography, Echocardiography, Heart physiopathology, Mitral Valve Insufficiency physiopathology, Myocardial Contraction
- Abstract
Among 22 patients with isolated mitral regurgitation of various origins, systolic time intervals (preejection period [PEP] index, left ventricular ejection time [LVET] index and PEP/LVET) and echocardiographic measures of left ventricular performance (end-diastolic diameter [Dd], end-systolic diameter [Ds], and the percent change in minor axis diameter [% delta D]) were calculated. The patients were classified into two groups, those with a normal or supernormal % delta D (group I, 15 patients) and those with a decreased % delta D (group II, 7 patients). On group analysis, prolongation of the preejection period, shortening of the left ventricular ejection time and an increase in PEP/LVET was generally characteristic of patients with mitral regurgitation. These changes were accentuated when mitral regurgitation was complicated by echocardiographic evidence of diminished left ventricular contractile performance (% delta D less than 30 percent). An increase in PEP/LVET to greater than 0.05 was consistently associated with abnormal left ventricular performance, whereas a normal PEP/LVET ratio reflected normal or supernormal left ventricular performance. An inverse linear relation was found between PEP/LVET and % delta D. When compared with previous data on the relation of these variables among patients without valve insufficiency, PEP/LVET proved to be increased for any level of % delta D in mitral regurgitation. The state of digitalization did not appear to influence the relation between PEP/LVET and % delta D. The use of echocardiographic measurements augments the determination of systolic time intervals in the analysis of left ventricular performance in patients with mitral regurgitation.
- Published
- 1976
- Full Text
- View/download PDF
42. The need for clarification of percent risk reduction data in clinical cardiovascular trial reports.
- Author
-
Weissler AM, Miller BI, and Boudoulas H
- Subjects
- Cardiovascular Diseases mortality, Humans, Risk, Cardiovascular Diseases drug therapy, Clinical Trials as Topic methods, Statistics as Topic
- Published
- 1989
- Full Text
- View/download PDF
43. Atrial pacing for cardioversion of atrial flutter in digitalized patients.
- Author
-
Das G, Anand KM, Ankineedu K, Chinnavaso T, Talmers FN, and Weissler AM
- Subjects
- Adult, Aged, Atrial Flutter drug therapy, Digitalis Glycosides administration & dosage, Humans, Male, Middle Aged, Atrial Flutter therapy, Cardiac Pacing, Artificial, Digitalis Glycosides therapeutic use, Electric Countershock
- Abstract
To test the safety and reliability of atrial pacing as a conversion technique in patients with atrial flutter who are receiving digitalis therapy, atrial pacing conversion was attempted for 49 episodes of atrial flutter in 32 consecutive patients. All patients except one were receiving digitalis. To control ventricular rates most patients had received larger than usual therapeutic doses of digitalis glycoside before pacing. Fourteen of the 25 patients whose serum levels were measured had glycoside concentrations greater than 2 ng/ml. Before atrial pacing the mean atrial and ventricular rates were, respectively, 290 +/- 20.6 and 134 +/- 27.9/min (mean +/- standard deviation). Successful rhythm conversion was achieved on 48 occasions (98%) in 31 patients. One patient required transthoracic direct current synchronized countershock cardioversion. With atrial pacing, the atrial flutter rhythm reverted immediately to sinus mechanism in 23 instances, and there were 25 episodes of atrial fibrillation. Among those who experienced atrial fibrillation, the rhythm spontaneously reverted to sinus mechanism within 24 hours on 14 occasions; on 11 occasions; the rhythm reverted to atrial flutter and repeat pacing was required. Sinus mechanism was eventually established in all 31 patients.
- Published
- 1978
- Full Text
- View/download PDF
44. Assessment of ventricular function by combined noninvasive measures: factors accounting for methodologic disparities.
- Author
-
Boudoulas H, Geleris P, Bush CA, Lewis RP, Fulkerson PK, Kolibash AJ, and Weissler AM
- Subjects
- Adult, Aged, Cardiac Catheterization, Cineangiography, Echocardiography, Hemodynamics, Humans, Middle Aged, Stroke Volume, Systole, Ventricular Function, Heart Diseases diagnosis, Heart Function Tests methods, Heart Ventricles physiopathology
- Abstract
We studied the predictive accuracy and disparities among cineventriculographic ejection fraction, pre-ejection period over left ventricular ejection time (PEP/LVET) obtained from the systolic time intervals and the percent shortening of the internal echocardiographic diameter (% delta D) in assessing left ventricular performance in 453 consecutive patients without valvular heart disease. In 308 patients all three tests were normal, and in 78 patients all three tests were abnormal. Overall agreement (predictive accuracy) among ejection fraction (normal greater than or equal to 57), % delta D (normal greater than or equal to 28%) and PEP/LVET (normal less than or equal to 0.42) was 85%. In 67 patients disparities among the tests as measures of global left ventricular performance were found. The major mechanisms accounting for such disparities were: (a) large segmental contraction abnormalities which selectively distort the % delta D and ejection fraction and (b) diminished isovolumic pressure (less than 45 mmHg) which distorts PEP/LVET. When patients with segmental contraction abnormalities and low isovolumic pressure were excluded the agreement between PEP/LVET and ejection fraction was 97%, ejection fraction and % delta D 98% and PEP/LVET and % delta D 97%. The combined uses of systolic time intervals and echocardiogram minimizes error due to segmental contraction abnormalities and isovolumic pressure. If both PEP/LVET and % delta D are concordant the agreement with ejection fraction is 94% for normal and 99% for abnormal left ventricular function.
- Published
- 1983
- Full Text
- View/download PDF
45. [Global left ventricular function in chronic stable angina: the role of myocardial infarction].
- Author
-
Weissler AM, Stack RS, and Sohn YH
- Subjects
- Chronic Disease, Female, Humans, Male, Middle Aged, Angina Pectoris physiopathology, Heart Ventricles physiopathology, Myocardial Infarction physiopathology
- Published
- 1980
46. James V. Warren: a tribute.
- Author
-
Weissler AM
- Subjects
- Cardiology history, History, 20th Century, United States
- Published
- 1988
47. Interpreting systolic time intervals in man.
- Author
-
Weissler AM
- Subjects
- Animals, Biomechanical Phenomena, Electrophysiology, Humans, In Vitro Techniques, Ventricular Function, Myocardial Contraction, Systole
- Published
- 1983
- Full Text
- View/download PDF
48. The onset and magnitude of the contractile response to commonly used digitalis glycosides in normal subjects.
- Author
-
Forester W, Lewis RP, Weissler AM, and Wilke TA
- Subjects
- Adult, Digoxin pharmacology, Dose-Response Relationship, Drug, Heart Failure drug therapy, Humans, Injections, Intravenous, Lanatosides administration & dosage, Male, Ouabain pharmacology, Strophanthins pharmacology, Time Factors, Heart Rate, Lanatosides pharmacology
- Published
- 1974
- Full Text
- View/download PDF
49. Usefulness of the systolic time intervals in cardiovascular clinical cardiology.
- Author
-
Lewis RP, Boudoulas H, Leier CV, Unverferth DV, and Weissler AM
- Subjects
- Digitalis Glycosides pharmacology, Dose-Response Relationship, Drug, Female, Heart Failure physiopathology, Heart Rate drug effects, Humans, Male, Procainamide pharmacology, Propranolol pharmacology, Sex Factors, Anti-Arrhythmia Agents pharmacology, Coronary Disease physiopathology, Myocardial Contraction drug effects, Systole drug effects
- Published
- 1982
50. The therapeutic implications of diastolic time changes in systemic hypertension.
- Author
-
Jawad IA, Kinhal V, Talmers F, Weissler AM, and Boudoulas H
- Subjects
- Adult, Aged, Antihypertensive Agents therapeutic use, Blood Pressure drug effects, Cardiomegaly drug therapy, Coronary Circulation drug effects, Humans, Hypertension drug therapy, Male, Middle Aged, Oxygen Consumption drug effects, Systole drug effects, Time Factors, Diastole drug effects, Hypertension physiopathology, Myocardial Contraction drug effects
- Abstract
Twenty-five patients with chronic systemic hypertension were studied. Systolic time intervals and diastolic time were determined at baseline and after 12 weeks of therapy with nadolol, with or without bendroflumethiazide (treatment phase I), then after 12 weeks of therapy with hydralazine, bendroflumethiazide, or both (treatment phase II). Systolic, diastolic, and mean blood pressures were equally controlled after either treatment regimen. Heart rate was significantly slower after treatment phase I compared to baseline or after treatment phase II (p less than 0.001). Systolic time per minute was significantly shorter and diastolic time per beat and per minute were significantly longer after treatment phase I compared to baseline or after treatment phase II (p less than 0.001). Double and triple products decreased after either mode of therapy; however, these parameters were significantly lower after treatment phase I compared to treatment phase II (p less than 0.01). These changes in systolic and diastolic time and double and triple products may be of clinical significance during therapy of chronic systemic hypertension and may help explain the regression of left ventricular hypertrophy in patients with hypertension treated with sympathetic blocking agents.
- Published
- 1985
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.