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2. The HEALthy Brain and Child Development Study (HBCD): NIH collaboration to understand the impacts of prenatal and early life experiences on brain development.

Author

Volkow, Nora, Gordon, Joshua, Bianchi, Diana, Chiang, Michael, Clayton, Janine, Klein, William, Koob, George, Koroshetz, Walter, Pérez-Stable, Eliseo, Simoni, Jane, Tromberg, Bruce, Woychik, Richard, Hommer, Rebecca, Spotts, Erica, Xu, Benjamin, Zehr, Julia, Cole, Katherine, Dowling, Gayathri, Freund, Michelle, Howlett, Katia, Jordan, Chloe, Murray, Traci, Pariyadath, Vani, Prabhakar, Janani, Rankin, Michele, Sarampote, Christopher, and Weiss, Susan

Subjects
Brain development, HBCD, Longitudinal, Neuroimaging, Prenatal substance use, Social determinants of health
Abstract

The human brain undergoes rapid development during the first years of life. Beginning in utero, a wide array of biological, social, and environmental factors can have lasting impacts on brain structure and function. To understand how prenatal and early life experiences alter neurodevelopmental trajectories and shape health outcomes, several NIH Institutes, Centers, and Offices collaborated to support and launch the HEALthy Brain and Child Development (HBCD) Study. The HBCD Study is a multi-site prospective longitudinal cohort study, that will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early childhood. Influenced by the success of the ongoing Adolescent Brain Cognitive DevelopmentSM Study (ABCD Study®) and in partnership with the NIH Helping to End Addiction Long-term® Initiative, or NIH HEAL Initiative®, the HBCD Study aims to establish a diverse cohort of over 7000 pregnant participants to understand how early life experiences, including prenatal exposure to addictive substances and adverse social environments as well as their interactions with an individuals genes, can affect neurodevelopmental trajectories and outcomes. Knowledge gained from the HBCD Study will help identify targets for early interventions and inform policies that promote resilience and mitigate the neurodevelopmental effects of adverse childhood experiences and environments.

Published
2024

9. Index

Author

Weiss, Susan M.

Published
2012

11. Contents

Author

Weiss, Susan M.

Published
2012

12. Foreword

Author

Weiss, Susan M.

Published
2012

14. Dedication

Author

Weiss, Susan M.

Published
2012

27. The HEALthy Brain and Child Development Study (HBCD): NIH collaboration to understand the impacts of prenatal and early life experiences on brain development

Author

Volkow, Nora D., Gordon, Joshua A., Bianchi, Diana W., Chiang, Michael F., Clayton, Janine A., Klein, William M., Koob, George F., Koroshetz, Walter J., Pérez-Stable, Eliseo J., Simoni, Jane M., Tromberg, Bruce J., Woychik, Richard P., Hommer, Rebecca, Spotts, Erica L., Xu, Benjamin, Zehr, Julia L., Cole, Katherine M., Dowling, Gayathri J., Freund, Michelle P., Howlett, Katia D., Jordan, Chloe J., Murray, Traci M., Pariyadath, Vani, Prabhakar, Janani, Rankin, Michele L., Sarampote, Christopher S., and Weiss, Susan R.B.

Published
2024
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29. The origins of SARS-CoV-2: A critical review

Author

Holmes, Edward C, Goldstein, Stephen A, Rasmussen, Angela L, Robertson, David L, Crits-Christoph, Alexander, Wertheim, Joel O, Anthony, Simon J, Barclay, Wendy S, Boni, Maciej F, Doherty, Peter C, Farrar, Jeremy, Geoghegan, Jemma L, Jiang, Xiaowei, Leibowitz, Julian L, Neil, Stuart JD, Skern, Tim, Weiss, Susan R, Worobey, Michael, Andersen, Kristian G, Garry, Robert F, and Rambaut, Andrew

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Biomedical and Clinical Sciences, Pneumonia, Emerging Infectious Diseases, Biodefense, Vaccine Related, Infectious Diseases, Prevention, Pneumonia & Influenza, Lung, Good Health and Well Being, Animals, Biological Evolution, COVID-19, Humans, Laboratories, SARS-CoV-2, Zoonoses, evolution, origins, zoonosis, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus in December 2019 in Wuhan, China, there has been intense interest in understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the human population. Recent debate has coalesced around two competing ideas: a "laboratory escape" scenario and zoonotic emergence. Here, we critically review the current scientific evidence that may help clarify the origin of SARS-CoV-2.

Published
2021

30. Correspondence Between Perceived Pubertal Development and Hormone Levels in 9-10 Year-Olds From the Adolescent Brain Cognitive Development Study

Author

Herting, Megan M, Uban, Kristina A, Gonzalez, Marybel Robledo, Baker, Fiona C, Kan, Eric C, Thompson, Wesley K, Granger, Douglas A, Albaugh, Matthew D, Anokhin, Andrey P, Bagot, Kara S, Banich, Marie T, Barch, Deanna M, Baskin-Sommers, Arielle, Breslin, Florence J, Casey, BJ, Chaarani, Bader, Chang, Linda, Clark, Duncan B, Cloak, Christine C, Constable, R Todd, Cottler, Linda B, Dagher, Rada K, Dapretto, Mirella, Dick, Anthony S, Dosenbach, Nico, Dowling, Gayathri J, Dumas, Julie A, Edwards, Sarah, Ernst, Thomas, Fair, Damien A, Feldstein-Ewing, Sarah W, Freedman, Edward G, Fuemmeler, Bernard F, Garavan, Hugh, Gee, Dylan G, Giedd, Jay N, Glaser, Paul EA, Goldstone, Aimee, Gray, Kevin M, Hawes, Samuel W, Heath, Andrew C, Heitzeg, Mary M, Hewitt, John K, Heyser, Charles J, Hoffman, Elizabeth A, Huber, Rebekah S, Huestis, Marilyn A, Hyde, Luke W, Infante, M Alejandra, Ivanova, Masha Y, Jacobus, Joanna, Jernigan, Terry L, Karcher, Nicole R, Laird, Angela R, LeBlanc, Kimberly H, Lisdahl, Krista, Luciana, Monica, Luna, Beatriz, Maes, Hermine H, Marshall, Andrew T, Mason, Michael J, McGlade, Erin C, Morris, Amanda S, Nagel, Bonnie J, Neigh, Gretchen N, Palmer, Clare E, Paulus, Martin P, Potter, Alexandra S, Puttler, Leon I, Rajapakse, Nishadi, Rapuano, Kristina, Reeves, Gloria, Renshaw, Perry F, Schirda, Claudiu, Sher, Kenneth J, Sheth, Chandni, Shilling, Paul D, Squeglia, Lindsay M, Sutherland, Matthew T, Tapert, Susan F, Tomko, Rachel L, Yurgelun-Todd, Deborah, Wade, Natasha E, Weiss, Susan RB, Zucker, Robert A, and Sowell, Elizabeth R

Subjects
Paediatrics, Biomedical and Clinical Sciences, Pediatric, Mental Health, Women's Health, Basic Behavioral and Social Science, Behavioral and Social Science, Clinical Research, Social Determinants of Health, Neurosciences, Metabolic and endocrine, Good Health and Well Being, Adolescent, Adolescent Development, Child, Child Development, Cross-Sectional Studies, Dehydroepiandrosterone, Estradiol, Female, Gonadal Steroid Hormones, Humans, Male, Puberty, Self Report, Sexual Maturation, Socioeconomic Factors, Testosterone, adolescent brain cognitive development, salivary hormones, pubertal development scale, puberty, testosterone, dehydroepiandrosterone, estradiol, Clinical Sciences, Nutrition and Dietetics, Clinical sciences
Abstract

AimTo examine individual variability between perceived physical features and hormones of pubertal maturation in 9-10-year-old children as a function of sociodemographic characteristics.MethodsCross-sectional metrics of puberty were utilized from the baseline assessment of the Adolescent Brain Cognitive Development (ABCD) Study-a multi-site sample of 9-10 year-olds (n = 11,875)-and included perceived physical features via the pubertal development scale (PDS) and child salivary hormone levels (dehydroepiandrosterone and testosterone in all, and estradiol in females). Multi-level models examined the relationships among sociodemographic measures, physical features, and hormone levels. A group factor analysis (GFA) was implemented to extract latent variables of pubertal maturation that integrated both measures of perceived physical features and hormone levels.ResultsPDS summary scores indicated more males (70%) than females (31%) were prepubertal. Perceived physical features and hormone levels were significantly associated with child's weight status and income, such that more mature scores were observed among children that were overweight/obese or from households with low-income. Results from the GFA identified two latent factors that described individual differences in pubertal maturation among both females and males, with factor 1 driven by higher hormone levels, and factor 2 driven by perceived physical maturation. The correspondence between latent factor 1 scores (hormones) and latent factor 2 scores (perceived physical maturation) revealed synchronous and asynchronous relationships between hormones and concomitant physical features in this large young adolescent sample.ConclusionsSociodemographic measures were associated with both objective hormone and self-report physical measures of pubertal maturation in a large, diverse sample of 9-10 year-olds. The latent variables of pubertal maturation described a complex interplay between perceived physical changes and hormone levels that hallmark sexual maturation, which future studies can examine in relation to trajectories of brain maturation, risk/resilience to substance use, and other mental health outcomes.

Published
2021

31. SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry

Author

Kee, John, Thudium, Samuel, Renner, David M., Glastad, Karl, Palozola, Katherine, Zhang, Zhen, Li, Yize, Lan, Yemin, Cesare, Joseph, Poleshko, Andrey, Kiseleva, Anna A., Truitt, Rachel, Cardenas-Diaz, Fabian L., Zhang, Xianwen, Xie, Xuping, Kotton, Darrell N., Alysandratos, Konstantinos D., Epstein, Johnathan A., Shi, Pei-Yong, Yang, Wenli, Morrisey, Edward, Garcia, Benjamin A., Berger, Shelley L., Weiss, Susan R., and Korb, Erica

Published
2022
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32. Correspondence Between Perceived Pubertal Development and Hormone Levels in 9-10 Year-Olds From the Adolescent Brain Cognitive Development Study.

Author

Herting, Megan M, Uban, Kristina A, Gonzalez, Marybel Robledo, Baker, Fiona C, Kan, Eric C, Thompson, Wesley K, Granger, Douglas A, Albaugh, Matthew D, Anokhin, Andrey P, Bagot, Kara S, Banich, Marie T, Barch, Deanna M, Baskin-Sommers, Arielle, Breslin, Florence J, Casey, BJ, Chaarani, Bader, Chang, Linda, Clark, Duncan B, Cloak, Christine C, Constable, R Todd, Cottler, Linda B, Dagher, Rada K, Dapretto, Mirella, Dick, Anthony S, Dosenbach, Nico, Dowling, Gayathri J, Dumas, Julie A, Edwards, Sarah, Ernst, Thomas, Fair, Damien A, Feldstein-Ewing, Sarah W, Freedman, Edward G, Fuemmeler, Bernard F, Garavan, Hugh, Gee, Dylan G, Giedd, Jay N, Glaser, Paul EA, Goldstone, Aimee, Gray, Kevin M, Hawes, Samuel W, Heath, Andrew C, Heitzeg, Mary M, Hewitt, John K, Heyser, Charles J, Hoffman, Elizabeth A, Huber, Rebekah S, Huestis, Marilyn A, Hyde, Luke W, Infante, M Alejandra, Ivanova, Masha Y, Jacobus, Joanna, Jernigan, Terry L, Karcher, Nicole R, Laird, Angela R, LeBlanc, Kimberly H, Lisdahl, Krista, Luciana, Monica, Luna, Beatriz, Maes, Hermine H, Marshall, Andrew T, Mason, Michael J, McGlade, Erin C, Morris, Amanda S, Nagel, Bonnie J, Neigh, Gretchen N, Palmer, Clare E, Paulus, Martin P, Potter, Alexandra S, Puttler, Leon I, Rajapakse, Nishadi, Rapuano, Kristina, Reeves, Gloria, Renshaw, Perry F, Schirda, Claudiu, Sher, Kenneth J, Sheth, Chandni, Shilling, Paul D, Squeglia, Lindsay M, Sutherland, Matthew T, Tapert, Susan F, Tomko, Rachel L, Yurgelun-Todd, Deborah, Wade, Natasha E, Weiss, Susan RB, Zucker, Robert A, and Sowell, Elizabeth R

Subjects
Humans, Dehydroepiandrosterone, Testosterone, Estradiol, Gonadal Steroid Hormones, Cross-Sectional Studies, Adolescent Development, Child Development, Puberty, Sexual Maturation, Socioeconomic Factors, Adolescent, Child, Female, Male, Self Report, adolescent brain cognitive development, dehydroepiandrosterone, estradiol, pubertal development scale, puberty, salivary hormones, testosterone, Pediatric, Behavioral and Social Science, Prevention, Pediatric Research Initiative, Clinical Research, Mental Health, Basic Behavioral and Social Science, Contraception/Reproduction, Mental health, Clinical Sciences, Nutrition and Dietetics
Abstract

AimTo examine individual variability between perceived physical features and hormones of pubertal maturation in 9-10-year-old children as a function of sociodemographic characteristics.MethodsCross-sectional metrics of puberty were utilized from the baseline assessment of the Adolescent Brain Cognitive Development (ABCD) Study-a multi-site sample of 9-10 year-olds (n = 11,875)-and included perceived physical features via the pubertal development scale (PDS) and child salivary hormone levels (dehydroepiandrosterone and testosterone in all, and estradiol in females). Multi-level models examined the relationships among sociodemographic measures, physical features, and hormone levels. A group factor analysis (GFA) was implemented to extract latent variables of pubertal maturation that integrated both measures of perceived physical features and hormone levels.ResultsPDS summary scores indicated more males (70%) than females (31%) were prepubertal. Perceived physical features and hormone levels were significantly associated with child's weight status and income, such that more mature scores were observed among children that were overweight/obese or from households with low-income. Results from the GFA identified two latent factors that described individual differences in pubertal maturation among both females and males, with factor 1 driven by higher hormone levels, and factor 2 driven by perceived physical maturation. The correspondence between latent factor 1 scores (hormones) and latent factor 2 scores (perceived physical maturation) revealed synchronous and asynchronous relationships between hormones and concomitant physical features in this large young adolescent sample.ConclusionsSociodemographic measures were associated with both objective hormone and self-report physical measures of pubertal maturation in a large, diverse sample of 9-10 year-olds. The latent variables of pubertal maturation described a complex interplay between perceived physical changes and hormone levels that hallmark sexual maturation, which future studies can examine in relation to trajectories of brain maturation, risk/resilience to substance use, and other mental health outcomes.

Published
2020

34. Image processing and analysis methods for the Adolescent Brain Cognitive Development Study

Author

Hagler, Donald J, Hatton, SeanN, Cornejo, M Daniela, Makowski, Carolina, Fair, Damien A, Dick, Anthony Steven, Sutherland, Matthew T, Casey, BJ, Barch, Deanna M, Harms, Michael P, Watts, Richard, Bjork, James M, Garavan, Hugh P, Hilmer, Laura, Pung, Christopher J, Sicat, Chelsea S, Kuperman, Joshua, Bartsch, Hauke, Xue, Feng, Heitzeg, Mary M, Laird, Angela R, Trinh, Thanh T, Gonzalez, Raul, Tapert, Susan F, Riedel, Michael C, Squeglia, Lindsay M, Hyde, Luke W, Rosenberg, Monica D, Earl, Eric A, Howlett, Katia D, Baker, Fiona C, Soules, Mary, Diaz, Jazmin, de Leon, Octavio Ruiz, Thompson, Wesley K, Neale, Michael C, Herting, Megan, Sowell, Elizabeth R, Alvarez, Ruben P, Hawes, Samuel W, Sanchez, Mariana, Bodurka, Jerzy, Breslin, Florence J, Morris, Amanda Sheffield, Paulus, Martin P, Simmons, W Kyle, Polimeni, Jonathan R, van der Kouwe, Andre, Nencka, Andrew S, Gray, Kevin M, Pierpaoli, Carlo, Matochik, John A, Noronha, Antonio, Aklin, Will M, Conway, Kevin, Glantz, Meyer, Hoffman, Elizabeth, Little, Roger, Lopez, Marsha, Pariyadath, Vani, Weiss, Susan RB, Wolff-Hughes, Dana L, DelCarmen-Wiggins, Rebecca, Ewing, Sarah W Feldstein, Miranda-Dominguez, Oscar, Nagel, Bonnie J, Perrone, Anders J, Sturgeon, Darrick T, Goldstone, Aimee, Pfefferbaum, Adolf, Pohl, Kilian M, Prouty, Devin, Uban, Kristina, Bookheimer, Susan Y, Dapretto, Mirella, Galvan, Adriana, Bagot, Kara, Giedd, Jay, Infante, M Alejandra, Jacobus, Joanna, Patrick, Kevin, Shilling, Paul D, Desikan, Rahul, Li, Yi, Sugrue, Leo, Banich, Marie T, Friedman, Naomi, Hewitt, John K, Hopfer, Christian, Sakai, Joseph, Tanabe, Jody, Cottler, Linda B, Nixon, Sara Jo, Chang, Linda, Cloak, Christine, Ernst, Thomas, Reeves, Gloria, Kennedy, David N, Heeringa, Steve, and Peltier, Scott

Subjects
Biomedical and Clinical Sciences, Health Sciences, Basic Behavioral and Social Science, Women's Health, Behavioral and Social Science, Brain Disorders, Pediatric, Drug Abuse (NIDA only), Mental Illness, Biomedical Imaging, Clinical Research, Mental Health, Substance Misuse, Neurosciences, Neurological, Mental health, Good Health and Well Being, Adolescent, Adolescent Development, Brain, Brain Mapping, Diffusion Magnetic Resonance Imaging, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Multimodal Imaging, Signal Processing, Computer-Assisted, Magnetic resonance imaging, ABCD, Data sharing, Processing pipeline, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery, Biomedical and clinical sciences, Health sciences
Abstract

The Adolescent Brain Cognitive Development (ABCD) Study is an ongoing, nationwide study of the effects of environmental influences on behavioral and brain development in adolescents. The main objective of the study is to recruit and assess over eleven thousand 9-10-year-olds and follow them over the course of 10 years to characterize normative brain and cognitive development, the many factors that influence brain development, and the effects of those factors on mental health and other outcomes. The study employs state-of-the-art multimodal brain imaging, cognitive and clinical assessments, bioassays, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning. The data is a resource of unprecedented scale and depth for studying typical and atypical development. The aim of this manuscript is to describe the baseline neuroimaging processing and subject-level analysis methods used by ABCD. Processing and analyses include modality-specific corrections for distortions and motion, brain segmentation and cortical surface reconstruction derived from structural magnetic resonance imaging (sMRI), analysis of brain microstructure using diffusion MRI (dMRI), task-related analysis of functional MRI (fMRI), and functional connectivity analysis of resting-state fMRI. This manuscript serves as a methodological reference for users of publicly shared neuroimaging data from the ABCD Study.

Published
2019

35. Activation of Alveolar Epithelial ER Stress by β-Coronavirus Infection Disrupt Surfactant Homeostasis in Mice: Implications for Covid-19 Respiratory Failure

Author

Murthy, Aditi, primary, Rodriguez, Luis R., additional, Dimopoulos, Thalia, additional, Bui, Sarah, additional, Iyer, Swati, additional, Chavez, Katrina, additional, Tomer, Yaniv, additional, Abraham, Valsamma, additional, Cooper, Charlotte, additional, Renner, David M., additional, Katzen, Jeremy B., additional, Bentley, Ian D., additional, Ghadiali, Samir N., additional, Englert, Joshua A., additional, Weiss, Susan R., additional, and Beers, Michael F., additional

Published
2024
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36. Comparison of SARS-CoV-2 variants of concern in primary human nasal cultures demonstrates Delta as most cytopathic and Omicron as fastest replicating

Author

Tanneti, Nikhila S., primary, Patel, Anant K., additional, Tan, Li Hui, additional, Marques, Andrew D., additional, Perera, Ranawaka A. P. M., additional, Sherrill-Mix, Scott, additional, Kelly, Brendan J., additional, Renner, David M., additional, Collman, Ronald G., additional, Rodino, Kyle, additional, Lee, Carole, additional, Bushman, Frederic D., additional, Cohen, Noam A., additional, and Weiss, Susan R., additional

Published
2024
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37. SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling

Author

Otter, Clayton J., primary, Bracci, Nicole, additional, Parenti, Nicholas A., additional, Ye, Chengjin, additional, Asthana, Abhishek, additional, Blomqvist, Ebba K., additional, Tan, Li Hui, additional, Pfannenstiel, Jessica J., additional, Jackson, Nathaniel, additional, Fehr, Anthony R., additional, Silverman, Robert H., additional, Burke, James M., additional, Cohen, Noam A., additional, Martinez-Sobrido, Luis, additional, and Weiss, Susan R., additional

Published
2024
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39. SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes

Author

Li, Yize, Renner, David M., Comar, Courtney E., Whelan, Jillian N., Reyes, Hanako M., Cardenas-Diaz, Fabian Leonardo, Truitt, Rachel, Tan, Li Hui, Dong, Beihua, Alysandratos, Konstantinos Dionysios, Huang, Jessie, Palmer, James N., Adappa, Nithin D., Kohanski, Michael A., Kotton, Darrell N., Silverman, Robert H., Yang, Wenli, Morrisey, Edward E., Cohen, Noam A., and Weiss, Susan R.

Published
2021

45. Correction for Rasmussen et al., “Virology—the path forward”

Author

Rasmussen, Angela L., primary, Gronvall, Gigi K., additional, Lowen, Anice C., additional, Goodrum, Felicia, additional, Alwine, James, additional, Andersen, Kristian G., additional, Anthony, Simon J., additional, Baines, Joel, additional, Banerjee, Arinjay, additional, Broadbent, Andrew J., additional, Brooke, Christopher B., additional, Campos, Samuel K., additional, Caposio, Patrizia, additional, Casadevall, Arturo, additional, Chan, Gary C., additional, Cliffe, Anna R., additional, Collins-McMillen, Donna, additional, Connell, Nancy, additional, Damania, Blossom, additional, Daugherty, Matthew D., additional, Debbink, Kari, additional, Dermody, Terence S., additional, DiMaio, Daniel, additional, Duprex, W. Paul, additional, Emerman, Michael, additional, Galloway, Denise A., additional, Garry, Robert F., additional, Goldstein, Stephen A., additional, Greninger, Alexander L., additional, Hartman, Amy L., additional, Hogue, Brenda G., additional, Horner, Stacy M., additional, Hotez, Peter J., additional, Jung, Jae U., additional, Kamil, Jeremy P., additional, Karst, Stephanie M., additional, Laimins, Lou, additional, Lakdawala, Seema S., additional, Landais, Igor, additional, Letko, Michael, additional, Lindenbach, Brett, additional, Liu, Shan-Lu, additional, Luftig, Micah, additional, McFadden, Grant, additional, Mehle, Andrew, additional, Morrison, Juliet, additional, Moscona, Anne, additional, Mühlberger, Elke, additional, Munger, Joshua, additional, Münger, Karl, additional, Murphy, Eain, additional, Neufeldt, Christopher J., additional, Nikolich, Janko Z., additional, O'Connor, Christine M., additional, Pekosz, Andrew, additional, Permar, Sallie R., additional, Pfeiffer, Julie K., additional, Popescu, Saskia V., additional, Purdy, John G., additional, Racaniello, Vincent R., additional, Rice, Charles M., additional, Runstadler, Jonathan A., additional, Sapp, Martin J., additional, Scott, Rona S., additional, Smith, Gregory A., additional, Sorrell, Erin M., additional, Speranza, Emily, additional, Streblow, Daniel, additional, Tibbetts, Scott A., additional, Toth, Zsolt, additional, Van Doorslaer, Koenraad, additional, Weiss, Susan R., additional, White, Elizabeth A., additional, White, Timothy M., additional, Wobus, Christiane E., additional, Worobey, Michael, additional, Yamaoka, Satoko, additional, and Yurochko, Andrew, additional

Published
2024
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47. Virology—the path forward

Author

Rasmussen, Angela L., primary, Gronvall, Gigi K., additional, Lowen, Anice C., additional, Goodrum, Felicia, additional, Alwine, James, additional, Andersen, Kristian G., additional, Anthony, Simon J., additional, Baines, Joel, additional, Banerjee, Arinjay, additional, Broadbent, Andrew J., additional, Brooke, Christopher B., additional, Campos, Samuel K., additional, Caposio, Patrizia, additional, Casadevall, Arturo, additional, Chan, Gary C., additional, Cliffe, Anna R., additional, Collins-McMillen, Donna, additional, Connell, Nancy, additional, Damania, Blossom, additional, Daugherty, Matthew D., additional, Debbink, Kari, additional, Dermody, Terence S., additional, DiMaio, Daniel, additional, Duprex, W. Paul, additional, Emerman, Michael, additional, Galloway, Denise A., additional, Garry, Robert F., additional, Goldstein, Stephen A., additional, Greninger, Alexander L., additional, Hartman, Amy L., additional, Hogue, Brenda G., additional, Horner, Stacy M., additional, Hotez, Peter J., additional, Jung, Jae U., additional, Kamil, Jeremy P., additional, Karst, Stephanie M., additional, Laimins, Lou, additional, Lakdawala, Seema S., additional, Landais, Igor, additional, Letko, Michael, additional, Lindenbach, Brett, additional, Liu, Shan-Lu, additional, Luftig, Micah, additional, McFadden, Grant, additional, Mehle, Andrew, additional, Morrison, Juliet, additional, Moscona, Anne, additional, Mühlberger, Elke, additional, Munger, Joshua, additional, Münger, Karl, additional, Murphy, Eain, additional, Neufeldt, Christopher J., additional, Nikolich, Janko Z., additional, O'Connor, Christine M., additional, Pekosz, Andrew, additional, Permar, Sallie R., additional, Pfeiffer, Julie K., additional, Popescu, Saskia V., additional, Purdy, John G., additional, Racaniello, Vincent R., additional, Rice, Charles M., additional, Runstadler, Jonathan A., additional, Sapp, Martin J., additional, Scott, Rona S., additional, Smith, Gregory A., additional, Sorrell, Erin M., additional, Speranza, Emily, additional, Streblow, Daniel, additional, Tibbetts, Scott A., additional, Toth, Zsolt, additional, Van Doorslaer, Koenraad, additional, Weiss, Susan R., additional, White, Elizabeth A., additional, White, Timothy M., additional, Wobus, Christiane E., additional, Worobey, Michael, additional, Yamaoka, Satoko, additional, and Yurochko, Andrew, additional

Published
2024
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48. Author Correction: SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry

Author

Kee, John, Thudium, Samuel, Renner, David M., Glastad, Karl, Palozola, Katherine, Zhang, Zhen, Li, Yize, Lan, Yemin, Cesare, Joseph, Poleshko, Andrey, Kiseleva, Anna A., Truitt, Rachel, Cardenas-Diaz, Fabian L., Zhang, Xianwen, Xie, Xuping, Kotton, Darrell N., Alysandratos, Konstantinos D., Epstein, Jonathan A., Shi, Pei-Yong, Yang, Wenli, Morrisey, Edward, Garcia, Benjamin A., Berger, Shelley L., Weiss, Susan R., and Korb, Erica

Published
2023
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49. Publisher Correction: SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry

Author

Kee, John, Thudium, Samuel, Renner, David M., Glastad, Karl, Palozola, Katherine, Zhang, Zhen, Li, Yize, Lan, Yemin, Cesare, Joseph, Poleshko, Andrey, Kiseleva, Anna A., Truitt, Rachel, Cardenas-Diaz, Fabian L., Zhang, Xianwen, Xie, Xuping, Kotton, Darrell N., Alysandratos, Konstantinos D., Epstein, Jonathan A., Shi, Pei-Yong, Yang, Wenli, Morrisey, Edward, Garcia, Benjamin A., Berger, Shelley L., Weiss, Susan R., and Korb, Erica

Published
2023
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50. Interferon signaling in the nasal epithelium distinguishes among lethal and common cold coronaviruses and mediates viral clearance.

Author

Otter, Clayton J., Renner, David M., Fausto, Alejandra, Li Hui Tan, Cohen, Noam A., and Weiss, Susan R.

Subjects
NASAL mucosa, COMMON cold, INTERFERONS, VIRUS diseases, EPITHELIAL cell culture, VACCINE manufacturing
Abstract

All respiratory viruses establish primary infections in the nasal epithelium, where efficient innate immune induction may prevent dissemination to the lower airway and thus minimize pathogenesis. Human coronaviruses (HCoVs) cause a range of pathologies, but the host and viral determinants of disease during common cold versus lethal HCoV infections are poorly understood. We model the initial site of infection using primary nasal epithelial cells cultured at an air-liquid interface (ALI). HCoV-229E, HCoV-NL63, and human rhinovirus-16 are common cold-associated viruses that exhibit unique features in this model: early induction of antiviral interferon (IFN) signaling, IFN-mediated viral clearance, and preferential replication at nasal airway temperature (33 °C) which confers muted host IFN responses. In contrast, lethal SARS-CoV-2 and MERS-CoV encode antagonist proteins that prevent IFN-mediated clearance in nasal cultures. Our study identifies features shared among common cold-associated viruses, highlighting nasal innate immune responses as predictive of infection outcomes and nasally directed IFNs as potential therapeutics. [ABSTRACT FROM AUTHOR]

Published
2024
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