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1. Vergleich von Endobiliärer Photodynamischer Therapie und Endobiliärer Radiofrequenzablation bei Patienten mit Extrahepatischem Cholangiokarzinom unter systemischer Chemotherapie

Author

Möhring, C., additional, Khan, O., additional, Zhou, T., additional, Sadeghlar, F., additional, Mahn, R., additional, Kaczmarek, D. J., additional, Dold, L., additional, Toma, M., additional, Marinova, M., additional, Glowka, T., additional, Matthaei, H., additional, Manekeller, S., additional, Kalff, J. C., additional, Strassburg, C. P., additional, Weismüller, T., additional, and Gonzalez-Carmona, M. A., additional

Published
2023
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3. SINGLE-OPERATOR VIDEO PANCREATOSCOPY (SOVP) FOR THE MANAGEMENT OF SYMPTOMATIC PANCREATIC DUCT STONES IN SELECTED CHRONIC PANCREATITIS PATIENTS. A PROSPECTIVE MULTICENTRE COHORT TRIAL

Author

Schmitz, L., additional, Cappello, A., additional, Albers, D., additional, Rousseau, M., additional, Schirra, J., additional, Goni, E., additional, Mayerle, J., additional, Casper, M., additional, Weismüller, T., additional, Dormann, A., additional, Hartmann, D., additional, Hollenbach, M., additional, Hampe, J., additional, Kandulski, A., additional, Hoffman, A., additional, Denzer, U., additional, Dechene, A., additional, Arlt, A., additional, Schlag, C., additional, Dollhopf, M., additional, Schumacher, B., additional, van Geenen, E., additional, Siersema, P., additional, Neuhaus, H., additional, Ellrichmann, M., additional, Beyna, T., additional, and Gerges, C., additional

Published
2022
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4. Follow-up magnetic resonance imaging/3D-magnetic resonance cholangiopancreatography in patients with primary sclerosing cholangitis: challenging for experts to interpret

Author

Zenouzi, R., Liwinski, T., Yamamura, J., Weiler-Normann, C., Sebode, M., Keller, S., Lohse, A. W., Schramm, C., Aabakken, L., Arrivé, L., Bowlus, C. L., Bungay, H., van Buuren, H. R., Cardinale, V., Carey, E. J., Chazouillères, O., Cheung, A., Culver, E. L., Dufour, J. F., Dumonceau, J. M., Eaton, J. E., Eddowes, P. J., Färkkilä, M., Floreani, A., Franceschet, I., Hohenester, S. D., Kemmerich, G., Krawczyk, M., Zimmer, V., Lenzen, H., Levy, C., Marschall, H. U., Marzioni, M., Motta, R., Muratori, L., Pereira, S. P., Poley, J. W., Rimola, J., Ringe, K. I., Rushbrook, S., Simpson, B. W., Schrumpf, E., Spina, J. C., Terziroli Beretta-Piccoli, B., Trauner, M., Tringali, A., Venkatesh, S. K., Vesterhus, M., Villamil, A., Weismüller, T. J., Ytting, H., Zenouzi, R., Liwinski, T., Yamamura, J., Weiler-Normann, C., Sebode, M., Keller, S., Lohse, A.W., Schramm, C., Aabakken, L., Arrivé, L., Bowlus, C.L., Bungay, H., van Buuren, H.R., Cardinale, V., Carey, E.J., Chazouillères, O., Cheung, A., Culver, E.L., Dufour, J.F., Dumonceau, J.M., Eaton, J.E., Eddowes, P.J., Färkkilä, M., Floreani, A., Franceschet, I., Hohenester, S.D., Kemmerich, G., Krawczyk, M., Zimmer, V., Lenzen, H., Levy, C., Marschall, H.U., Marzioni, M., Motta, R., Muratori, L., Pereira, S.P., Poley, J.W., Rimola, J., Ringe, K.I., Rushbrook, S., Simpson, B.W., Schrumpf, E., Spina, J.C., Terziroli Beretta-Piccoli, B., Trauner, M., Tringali, A., Venkatesh, S.K., Vesterhus, M., Villamil, A., Weismüller, T.J., Ytting, H., Culver, E, and Gastroenterology & Hepatology

Subjects
Adult, Liver Cirrhosis, Male, medicine.medical_specialty, Cirrhosis, Cholangiopancreatography, Magnetic Resonance, Cholangitis, Sclerosing, Constriction, Pathologic, Primary sclerosing cholangitis, Cholangiocarcinoma, Diagnosis, Differential, 03 medical and health sciences, Imaging, Three-Dimensional, 0302 clinical medicine, Surveys and Questionnaires, Image Interpretation, Computer-Assisted, medicine, Humans, Pharmacology (medical), In patient, Expert Testimony, Cholangiopancreatography, Endoscopic Retrograde, Magnetic resonance cholangiopancreatography, Endoscopic retrograde cholangiopancreatography, Hepatology, medicine.diagnostic_test, business.industry, Elevated total bilirubin, Gastroenterology, Reproducibility of Results, Magnetic resonance imaging, Middle Aged, medicine.disease, Bile Ducts, Intrahepatic, Bile Duct Neoplasms, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Clinical Competence, Radiology, Bilirubin levels, business, Follow-Up Studies
Abstract

Background: In patients with primary sclerosing cholangitis follow‐up magnetic resonance imaging (MRI) with magnetic resonance cholangiopancreatography (MRCP) is performed by many centres, particularly for the early detection of biliary malignancies and strictures. Clinically meaningful MRI‐based definitions of primary sclerosing cholangitis related complications are, however, lacking.Aim: To investigate how primary sclerosing cholangitis experts interpret follow‐up MRI/MRCP with a focus on conclusions that may impact clinical decision‐making in primary sclerosing cholangitis.Methods: Within the International Primary Sclerosing Cholangitis Study Group, an online survey on 16 real‐life primary sclerosing cholangitis cases including clinical and biochemical information as well as a T2‐weighted liver MRI/3D‐MRCP was conducted. The interpretation of images and subsequent recommendations were assessed using a multiple‐choice questionnaire. An inter‐rater reliability calculation (Fleiss′ kappa) was performed and factors potentially affecting the interpretation of magnetic resonance images were analysed using generalised linear mixed‐effect models.Results: Forty‐four members/associates of the International Primary Sclerosing Cholangitis Study Group (median experience in the care of primary sclerosing cholangitis patients: 14 years) completed the survey. The MRI interpretation significantly varied among the participants. The lowest agreement was found with respect to the indication to perform subsequent endoscopic retrograde cholangiopancreatography (ERCP; Κ = 0.12, 95%CI 0.11‐0.14). Elevated total bilirubin was the variable with the strongest effect on the rate of suspected dominant strictures, cholangiocarcinoma or ERCP recommendations. Liver cirrhosis did not prevent participants from recommending ERCP. Overall, the survey participants′ recommendations contrasted the real‐life management and outcome.Conclusions: In primary sclerosing cholangitis, the interpretation of follow‐up MRI/3D‐MRCP significantly varies even among experts and seems to be primarily affected by bilirubin levels. Generally accepted MRI‐based definitions of primary sclerosing cholangitis‐related complications are urgently needed.

Published
2018
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5. Multiparametrisches MRT basiertes Mapping der Leber zur nicht-invasiven Bestimmung des Fibrosegrades bei Patienten mit primär sklerosierender Cholangitis.

Author

Mesropyan, N, additional, Kupczyk, P, additional, Dold, L, additional, Weismüller, T, additional, Sprinkart, M, additional, Pieper, C, additional, Kütting, D, additional, Strassburg, C, additional, Isaak, A, additional, Endler, C, additional, Faron, A, additional, Attenberger, U, additional, and Luetkens, J, additional

Published
2021
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8. Dye chromoendoscopy leads to a higher adenoma detection in the duodenum and stomach in patients with familial adenomatous polyposis

Author

Strassburg, C. P., primary, Nattermann, J., primary, Hüneburg, R., additional, Heling, D., additional, Kaczmarek, D. J., additional, van Heteren, P., additional, Olthaus, M., additional, Fimmers, R., additional, Berger, M., additional, Coch, C., additional, Lau, J. F., additional, Kristiansen, G., additional, Weismüller, T. J., additional, Spier, I., additional, and Aretz, S., additional

Published
2020
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9. The bacterial bile microbiome and its role in liver diseases

Author

Tyc, O, additional, Jansen, C, additional, Schierwagen, R, additional, Uschner, F, additional, Israelsen, M, additional, Klein, S, additional, Ortiz, C, additional, Strassburg, C, additional, Zeuzem, S, additional, Gu, W, additional, Torres, S, additional, Praktiknjo, M, additional, Kersting, S, additional, Langheinrich, M, additional, Nattermann, J, additional, Servant, F, additional, Arumugam, M, additional, Krag, A, additional, Lelouvier, B, additional, Weismüller, T, additional, and Trebicka, J, additional

Published
2020
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15. Recommendations on the use of magnetic resonance imaging for collaborative multicenter studies in PSC

Author

Ringe, Kristina I, Grigoriadis, Aristeidis, Halibasic, Emina, Wacker, Frank, Manns, Michael P, Schramm, Christoph, Lenzen, Henrike, Collaborators: Alvaro D, MRI working group of the IPSCSG., Arrivé, L, Ba-Ssalamah, A, Bergquist, A, Bungay, H, Cardinale, V, Cazzagon, N, Chengija, V, Eaton, J, Färkkilä, M, Floreani, A, Kemmerich, G, Kukuk, G, Madrazo, B, Pötter-Lang, S, Stadnik, A, Tenca, A, Trauner, M, Venkatesh, S, Weismüller, T, Yamamura, J, and Zenouzi, R.

Published
2018

17. Chromoendoskopie versus konventionelle Endoskopie im oberen Gastrointestinaltrakt bei Patienten mit familiärer adenomatöser Polyposis (ChroPol-I)

Author

Hüneburg, R, additional, Heling, D, additional, Kaczmarek, DJ, additional, van Heteren, P, additional, Fimmers, R, additional, Coch, C, additional, Kristiansen, G, additional, Weismüller, T, additional, Spier, I, additional, Aretz, S, additional, Strassburg, CP, additional, and Nattermann, J, additional

Published
2018
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20. Combined photodynamic therapy with systemic chemotherapy improves survival of patients with irresectable cholangiocarcinoma

Author

Gonzalez-Carmona, M.A., primary, Bolch, M., additional, Jansen, C., additional, Vogt, A., additional, Sampels, M., additional, van Beekum, K., additional, Mahn, R., additional, Praktiknjo, M., additional, Nattermann, J., additional, Trebicka, J., additional, Branchi, V., additional, Matthaei, H., additional, Manekeller, S., additional, Kalff, J., additional, Strassburg, C.P., additional, and Weismüller, T., additional

Published
2018
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21. Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis

Author

Alberts, R, De Vries, E, Goode, E, Jiang, X, Sampaziotis, F, Rombouts, K, Böttcher, K, Folseraas, T, Weismüller, T, Mason, A, Wang, W, Alexander, G, Alvaro, D, Bergquist, A, Björkström, N, Beuers, U, Björnsson, E, Boberg, K, Bowlus, C, Bragazzi, M, Carbone, M, Chazouillères, O, Cheung, A, Dalekos, G, Eaton, J, Eksteen, B, Ellinghaus, D, Färkkilä, M, Festen, E, Floreani, A, Franceschet, I, Gotthardt, D, Hirschfield, G, Hoek, B, Holm, K, Hohenester, S, Hov, J, Imhann, F, Invernizzi, P, Juran, B, Lenzen, H, Lieb, W, Liu, J, Marschall, H, Marzioni, M, Melum, E, Milkiewicz, P, Müller, T, Pares, A, Rupp, C, Rust, C, Sandford, R, Schramm, C, Schreiber, S, Schrumpf, E, Silverberg, M, Srivastava, B, Sterneck, M, Teufel, A, Vallier, L, Verheij, J, Vila, A, Vries, B, Zachou, K, Chapman, R, Manns, M, Pinzani, M, Rushbrook, S, Lazaridis, K, Franke, A, Anderson, C, Karlsen, T, Ponsioen, C, Weersma, R, Alberts, R, De Vries, E, Goode, E, Jiang, X, Sampaziotis, F, Rombouts, K, Böttcher, K, Folseraas, T, Weismüller, T, Mason, A, Wang, W, Alexander, G, Alvaro, D, Bergquist, A, Björkström, N, Beuers, U, Björnsson, E, Boberg, K, Bowlus, C, Bragazzi, M, Carbone, M, Chazouillères, O, Cheung, A, Dalekos, G, Eaton, J, Eksteen, B, Ellinghaus, D, Färkkilä, M, Festen, E, Floreani, A, Franceschet, I, Gotthardt, D, Hirschfield, G, Hoek, B, Holm, K, Hohenester, S, Hov, J, Imhann, F, Invernizzi, P, Juran, B, Lenzen, H, Lieb, W, Liu, J, Marschall, H, Marzioni, M, Melum, E, Milkiewicz, P, Müller, T, Pares, A, Rupp, C, Rust, C, Sandford, R, Schramm, C, Schreiber, S, Schrumpf, E, Silverberg, M, Srivastava, B, Sterneck, M, Teufel, A, Vallier, L, Verheij, J, Vila, A, Vries, B, Zachou, K, Chapman, R, Manns, M, Pinzani, M, Rushbrook, S, Lazaridis, K, Franke, A, Anderson, C, Karlsen, T, Ponsioen, C, and Weersma, R

Abstract

Objective Primary sclerosing cholangitis (PSC) is a genetically complex, inflammatory bile duct disease of largely unknown aetiology often leading to liver transplantation or death. Little is known about the genetic contribution to the severity and progression of PSC. The aim of this study is to identify genetic variants associated with PSC disease progression and development of complications. Design We collected standardised PSC subphenotypes in a large cohort of 3402 patients with PSC. After quality control, we combined 130 422 single nucleotide polymorphisms of all patients - obtained using the Illumina immunochip - with their disease subphenotypes. Using logistic regression and Cox proportional hazards models, we identified genetic variants associated with binary and time-to-event PSC subphenotypes. Results We identified genetic variant rs853974 to be associated with liver transplant-free survival (p=6.07×10 -9). Kaplan-Meier survival analysis showed a 50.9% (95% CI 41.5% to 59.5%) transplant-free survival for homozygous AA allele carriers of rs853974 compared with 72.8% (95% CI 69.6% to 75.7%) for GG carriers at 10 years after PSC diagnosis. For the candidate gene in the region, RSPO3, we demonstrated expression in key liver-resident effector cells, such as human and murine cholangiocytes and human hepatic stellate cells. Conclusion We present a large international PSC cohort, and report genetic loci associated with PSC disease progression. For liver transplant-free survival, we identified a genome-wide significant signal and demonstrated expression of the candidate gene RSPO3 in key liver-resident effector cells. This warrants further assessments of the role of this potential key PSC modifier gene.

Published
2018

23. Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease

Author

Ji, S, Juran, B, Mucha, S, Folseraas, T, Jostins, L, Melum, E, Kumasaka, N, Atkinson, E, Schlicht, E, Liu, J, Shah, T, Gutierrez Achury, J, Boberg, K, Bergquist, A, Vermeire, S, Eksteen, B, Durie, P, Farkkila, M, Müller, T, Schramm, C, Sterneck, M, Weismüller, T, Gotthardt, D, Ellinghaus, D, Braun, F, Teufel, A, Laudes, M, Lieb, W, Jacobs, G, Beuers, U, Weersma, R, Wijmenga, C, Marschall, H, Milkiewicz, P, Pares, A, Kontula, K, Chazouillères, O, Invernizzi, P, Goode, E, Spiess, K, Moore, C, Sambrook, J, Ouwehand, W, Roberts, D, Danesh, J, Floreani, A, Gulamhusein, A, Eaton, J, Schreiber, S, Coltescu, C, Bowlus, C, Luketic, V, Odin, J, Chopra, K, Kowdley, K, Chalasani, N, Manns, M, Srivastava, B, Mells, G, Sandford, R, Alexander, G, Gaffney, D, Chapman, R, Hirschfield, G, de Andrade, M, Rushbrook, S, Franke, A, Karlsen, T, Lazaridis, K, Anderson, C, INVERNIZZI, PIETRO, Anderson, C., Ji, S, Juran, B, Mucha, S, Folseraas, T, Jostins, L, Melum, E, Kumasaka, N, Atkinson, E, Schlicht, E, Liu, J, Shah, T, Gutierrez Achury, J, Boberg, K, Bergquist, A, Vermeire, S, Eksteen, B, Durie, P, Farkkila, M, Müller, T, Schramm, C, Sterneck, M, Weismüller, T, Gotthardt, D, Ellinghaus, D, Braun, F, Teufel, A, Laudes, M, Lieb, W, Jacobs, G, Beuers, U, Weersma, R, Wijmenga, C, Marschall, H, Milkiewicz, P, Pares, A, Kontula, K, Chazouillères, O, Invernizzi, P, Goode, E, Spiess, K, Moore, C, Sambrook, J, Ouwehand, W, Roberts, D, Danesh, J, Floreani, A, Gulamhusein, A, Eaton, J, Schreiber, S, Coltescu, C, Bowlus, C, Luketic, V, Odin, J, Chopra, K, Kowdley, K, Chalasani, N, Manns, M, Srivastava, B, Mells, G, Sandford, R, Alexander, G, Gaffney, D, Chapman, R, Hirschfield, G, de Andrade, M, Rushbrook, S, Franke, A, Karlsen, T, Lazaridis, K, Anderson, C, INVERNIZZI, PIETRO, and Anderson, C.

Abstract

Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction; ∼75% of patients have comorbid inflammatory bowel disease (IBD). We undertook the largest genome-wide association study of PSC (4,796 cases and 19,955 population controls) and identified four new genome-wide significant loci. The most associated SNP at one locus affects splicing and expression of UBASH3A, with the protective allele (C) predicted to cause nonstop-mediated mRNA decay and lower expression of UBASH3A. Further analyses based on common variants suggested that the genome-wide genetic correlation (rG) between PSC and ulcerative colitis (UC) (rG = 0.29) was significantly greater than that between PSC and Crohn's disease (CD) (rG = 0.04) (P = 2.55 × 10-15). UC and CD were genetically more similar to each other (rG = 0.56) than either was to PSC (P < 1.0 × 10-15). Our study represents a substantial advance in understanding of the genetics of PSC

Published
2017

32. Fremdkörperingestion und Bolusobstruktion – retrospektive Analyse einer großen Kohorte aus einer universitären interdisziplinären Notaufnahme

Author

Schlabe, S, primary, Hausen, A, additional, van Heteren, P, additional, Gräff, I, additional, Schild, H, additional, Bootz, F, additional, van Bremen, T, additional, Trebicka, J, additional, Wasmuth, J, additional, Nattermann, J, additional, Strassburg, C, additional, and Weismüller, T, additional

Published
2015
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39. Der Simplified AIH Score – Kriterium zur Einleitung einer Immunsuppression bei Patienten mit Primär Sklerosierender Cholangitis: Ergebnisse einer deutschen Multicenter Studie

Author

Schulze, K, primary, Weismüller, T, additional, Hübener, P, additional, Zenouzi, R, additional, Gotthardt, D, additional, de Leuw, P, additional, Bubenheim, M, additional, Teufel, A, additional, Zimmer, V, additional, Lenzen, H, additional, Reiter, F, additional, Rust, C, additional, Tharun, L, additional, Quaas, A, additional, Lammert, F, additional, Galle, PR, additional, Sarrazin, C, additional, Manns, M, additional, Lohse, AW, additional, and Schramm, C, additional

Published
2014
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41. Primär sklerosierende Cholangitis/autoimmune Hepatitis Überlappungssyndrom: Klinische Charakteristika und Kriterien für die Einleitung einer Immunsuppression

Author

Schulze, K, primary, Weismüller, T, additional, Hübener, P, additional, Zenouzi, R, additional, Gotthardt, D, additional, de Leuw, P, additional, Teufel, A, additional, Zimmer, V, additional, Reiter, FP, additional, Lenzen, H, additional, Rust, C, additional, Tharun, L, additional, Quaas, A, additional, Lammert, F, additional, Galle, PR, additional, Sarrazin, C, additional, Manns, M, additional, Lohse, AW, additional, and Schramm, C, additional

Published
2013
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42. Chromoendoskopie und multiple Biopsien detektieren Magenkarzinome nicht ausreichend bei Anlageträgern für ein familiäres Magenkarzinom

Author

Hüneburg, R, primary, van Heteren, P, additional, Siegmund, S, additional, Trebicka, J, additional, Weismüller, T, additional, Aretz, S, additional, Decker, C, additional, Glowka, T, additional, Standop, J, additional, Knüchel-Clarke, R, additional, Buettner, R, additional, Perez Bouza, A, additional, Kristiansen, G, additional, and Strassburg, CP, additional

Published
2013
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43. 954 PRIMARY SCLEROSING CHOLANGITIS WITH FEATURES OF AUTOIMMUNE HEPATITIS: CHARACTERISTICS AT FIRST PRESENTATION AND LONG TERM OUTCOME IN A LARGE, MULTICENTER COHORT FROM GERMANY

Author

Schulze, K., primary, Weismüller, T., additional, Hübener, P., additional, Zenouzi, R., additional, Gotthardt, D., additional, de Leuw, P., additional, Teufel, A., additional, Zimmer, V., additional, Rust, C., additional, Tharun, L., additional, Quaas, A., additional, Lammert, F., additional, Galle, P., additional, Sarrazin, C., additional, Manns, M., additional, Lohse, A., additional, and Schramm, C., additional

Published
2013
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