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1. Compiling with Arrays

Author

Richter, David, Böhler, Timon, Weisenburger, Pascal, and Mezini, Mira

Subjects
Computer Science - Programming Languages
Abstract

Linear algebra computations are foundational for neural networks and machine learning, often handled through arrays. While many functional programming languages feature lists and recursion, arrays in linear algebra demand constant-time access and bulk operations. To bridge this gap, some languages represent arrays as (eager) functions instead of lists. In this paper, we connect this idea to a formal logical foundation by interpreting functions as the usual negative types from polarized type theory, and arrays as the corresponding dual positive version of the function type. Positive types are defined to have a single elimination form whose computational interpretation is pattern matching. Just like (positive) product types bind two variables during pattern matching, (positive) array types bind variables with multiplicity during pattern matching. We follow a similar approach for Booleans by introducing conditionally-defined variables. The positive formulation for the array type enables us to combine typed partial evaluation and common subexpression elimination into an elegant algorithm whose result enjoys a property we call maximal fission, which we argue can be beneficial for further optimizations. For this purpose, we present the novel intermediate representation indexed administrative normal form (AiNF), which relies on the formal logical foundation of the positive formulation for the array type to facilitate maximal loop fission and subsequent optimizations. AiNF is normal with regard to commuting conversion for both let-bindings and for-loops, leading to flat and maximally fissioned terms. We mechanize the translation and normalization from a simple surface language to AiNF, establishing that the process terminates, preserves types, and produces maximally fissioned terms., Comment: to appear at ECOOP'24

Published
2024

4. A Direct-Style Effect Notation for Sequential and Parallel Programs

Author

Richter, David, Böhler, Timon, Weisenburger, Pascal, and Mezini, Mira

Subjects
Computer Science - Programming Languages
Abstract

Modeling sequential and parallel composition of effectful computations has been investigated in a variety of languages for a long time. In particular, the popular do-notation provides a lightweight effect embedding for any instance of a monad. Idiom bracket notation, on the other hand, provides an embedding for applicatives. First, while monads force effects to be executed sequentially, ignoring potential for parallelism, applicatives do not support sequential effects. Composing sequential with parallel effects remains an open problem. This is even more of an issue as real programs consist of a combination of both sequential and parallel segments. Second, common notations do not support invoking effects in direct-style, instead forcing a rigid structure upon the code. In this paper, we propose a mixed applicative/monadic notation that retains parallelism where possible, but allows sequentiality where necessary. We leverage a direct-style notation where sequentiality or parallelism is derived from the structure of the code. We provide a mechanisation of our effectful language in Coq and prove that our compilation approach retains the parallelism of the source program., Comment: to be published in ECOOP23

Published
2023
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5. Time to treatment with bridging intravenous alteplase before endovascular treatment:subanalysis of the randomized controlled SWIFT-DIRECT trial.

Author

Meinel, Thomas, Kaesmacher, Johannes, Buetikofer, Lukas, Strbian, Daniel, Eker, Omer, Cognard, Christophe, Mordasini, Pasquale, Deppeler, Sandro, Mendes Pereira, Vitor, Albucher, Jean, Darcourt, Jean, Bourcier, Romain, Guillon, Benoit, Papagiannaki, Chrysanthi, Costentin, Guillaume, Sibolt, Gerli, Räty, Silja, Gory, Benjamin, Richard, Sébastien, Liman, Jan, Ernst, Marielle, Boulanger, Marion, Barbier, Charlotte, Mechtouff, Laura, Zhang, Liqun, Marnat, Gaultier, Sibon, Igor, Nikoubashman, Omid, Reich, Arno, Consoli, Arturo, Weisenburger, David, Requena, Manuel, Garcia-Tornel, Alvaro, Saleme, Suzana, Moulin, Solène, Pagano, Paolo, Saliou, Guillaume, Carrera, Emmanuel, Janot, Kevin, Boix, Marti, Pop, Raoul, Della Schiava, Lucie, Luft, Andreas, Piotin, Michel, Gentric, Jean, Pikula, Aleksandra, Pfeilschifter, Waltraud, Arnold, Marcel, Siddiqui, Adnan, Froehler, Michael, Furlan, Anthony, Chapot, René, Wiesmann, Martin, Machi, Paolo, Diener, Hans-Christoph, Kulcsar, Zsolt, Bonati, Leo, Bassetti, Claudio, Escalard, Simon, Liebeskind, David, Saver, Jeffrey, Fischer, Urs, and Gralla, Jan

Subjects
Thrombectomy, Thrombolysis, Humans, Female, Aged, Male, Tissue Plasminogen Activator, Stroke, Time-to-Treatment, Thrombolytic Therapy, Thrombectomy, Brain Ischemia, Treatment Outcome, Fibrinolytic Agents
Abstract

BACKGROUND: We hypothesized that treatment delays might be an effect modifier regarding risks and benefits of intravenous thrombolysis (IVT) before mechanical thrombectomy (MT). METHODS: We used the dataset of the SWIFT-DIRECT trial, which randomized 408 patients to IVT+MT or MT alone. Potential interactions between assignment to IVT+MT and expected time from onset-to-needle (OTN) as well as expected time from door-to-needle (DTN) were included in regression models. The primary outcome was functional independence (modified Rankin Scale (mRS) 0-2) at 3 months. Secondary outcomes included mRS shift, mortality, recanalization rates, and (symptomatic) intracranial hemorrhage at 24 hours. RESULTS: We included 408 patients (IVT+MT 207, MT 201, median age 72 years (IQR 64-81), 209 (51.2%) female). The expected median OTN and DTN were 142 min and 54 min in the IVT+MT group and 129 min and 51 min in the MT alone group. Overall, there was no significant interaction between OTN and bridging IVT assignment regarding either the functional (adjusted OR (aOR) 0.76, 95% CI 0.45 to 1.30) and safety outcomes or the recanalization rates. Analysis of in-hospital delays showed no significant interaction between DTN and bridging IVT assignment regarding the dichotomized functional outcome (aOR 0.48, 95% CI 0.14 to 1.62), but the shift and mortality analyses suggested a greater benefit of IVT when in-hospital delays were short. CONCLUSIONS: We found no evidence that the effect of bridging IVT on functional independence is modified by overall or in-hospital treatment delays. Considering its low power, this subgroup analysis could have missed a clinically important effect, and exploratory analysis of secondary clinical outcomes indicated a potentially favorable effect of IVT with shorter in-hospital delays. Heterogeneity of the IVT effect size before MT should be further analyzed in individual patient meta-analysis of comparable trials. TRIAL REGISTRATION NUMBER: URL: https://www. CLINICALTRIALS: gov ; Unique identifier: NCT03192332.

Published
2023

7. Bridging Between Active Objects: Multitier Programming for Distributed, Concurrent Systems

Author

Salvaneschi, Guido, Weisenburger, Pascal, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, de Boer, Frank, editor, Damiani, Ferruccio, editor, Hähnle, Reiner, editor, Broch Johnsen, Einar, editor, and Kamburjan, Eduard, editor

Published
2024
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10. Prisma: A Tierless Language for Enforcing Contract-Client Protocols in Decentralized Applications (Extended Version)

Author

Richter, David, Kretzler, David, Weisenburger, Pascal, Salvaneschi, Guido, Faust, Sebastian, and Mezini, Mira

Subjects
Computer Science - Programming Languages
Abstract

Decentralized applications (dApps) consist of smart contracts that run on blockchains and clients that model collaborating parties. dApps are used to model financial and legal business functionality. Today, contracts and clients are written as separate programs -- in different programming languages -- communicating via send and receive operations. This makes distributed program flow awkward to express and reason about, increasing the potential for mismatches in the client-contract interface, which can be exploited by malicious clients, potentially leading to huge financial losses. In this paper, we present Prisma, a language for tierless decentralized applications, where the contract and its clients are defined in one unit and pairs of send and receive actions that "belong together" are encapsulated into a single direct-style operation, which is executed differently by sending and receiving parties. This enables expressing distributed program flow via standard control flow and renders mismatching communication impossible. We prove formally that our compiler preserves program behavior in presence of an attacker controlling the client code. We systematically compare Prisma with mainstream and advanced programming models for dApps and provide empirical evidence for its expressiveness and performance., Comment: This is the extended version including appendices of the paper to be published in TOPLAS; an extended abstract was published in ECOOP 2022

Published
2022

12. Refining Diagnostic Subtypes of Peripheral T-Cell Lymphoma Using a Multiparameter Approach

Author

Amador, Catalina, Weisenburger, Dennis D., Gomez, Ana, Bouska, Alyssa, Alshomrani, Ahmad, Sharma, Sunandini, Shah, Ab Rauf, Greiner, Timothy C., Vega, Francisco, Rosenwald, Andreas, Ott, German, Feldman, Andrew L., Jaffe, Elaine S., Ozkaya, Neval, Ondrejka, Sarah L., Cook, James R., Raess, Philipp W., Savage, Kerry J., Slack, Graham W., Song, Joo Y., Scott, David W., Campo, Elias, Rimsza, Lisa M., Khoury, Joseph D., Staudt, Louis M., Chan, Wing C., and Iqbal, Javeed

Published
2025
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15. Motive and opportunity: MYC rearrangements in high-grade B-cell lymphoma with MYC and BCL2 rearrangements (an LLMPP study)

Author

Hilton, Laura K., Collinge, Brett, Ben-Neriah, Susana, Alduaij, Waleed, Shaalan, Haya, Weng, Andrew P., Cruz, Manuela, Slack, Graham W., Farinha, Pedro, Miyata-Takata, Tomoko, Boyle, Merrill, Meissner, Barbara, Cook, James R., Ondrejka, Sarah L., Ott, German, Rosenwald, Andreas, Campo, Elias, Amador, Catalina, Greiner, Timothy C., Raess, Philipp W., Song, Joo Y., Inghirami, Giorgio, Jaffe, Elaine S., Weisenburger, Dennis D., Chan, Wing C., Beiske, Klaus, Fu, Kai, Delabie, Jan, Pittaluga, Stefania, Iqbal, Javeed, Wright, George, Sehn, Laurie H., Savage, Kerry J., Mungall, Andrew J., Feldman, Andrew L., Staudt, Louis M., Steidl, Christian, Rimsza, Lisa M., Morin, Ryan D., and Scott, David W.

Published
2024
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16. Integrative analysis of clinicopathological features defines novel prognostic models for mantle cell lymphoma in the immunochemotherapy era: a report from The North American Mantle Cell Lymphoma Consortium

Author

Julie M. Vose, Kai Fu, Lu Wang, Adnan Mansoor, Douglas Stewart, Hongxia Cheng, Lynette Smith, Ji Yuan, Hina Naushad Qureishi, Brian K. Link, Melissa H. Cessna, Paul M. Barr, Brad S. Kahl, Matthew S. Mckinney, Nadia Khan, Ranjana H. Advani, Peter Martin, Andre H. Goy, Tycel J. Phillips, Amitkumar Mehta, Manali Kamdar, Michael Crump, Barbara Pro, Christopher R. Flowers, Caron A. Jacobson, Sonali M. Smith, Deborah M. Stephens, Veronika Bachanova, Zhaohui Jin, Shishou Wu, Francisco Hernandez-Ilizaliturri, Pallawi Torka, Andrea Anampa-Guzmán, Farshid Kashef, Xing Li, Sunandini Sharma, Timothy C. Greiner, James O. Armitage, Matthew Lunning, Dennis D. Weisenburger, Robert G. Bociek, Javeed Iqbal, Guohua Yu, Chengfeng Bi, and the North American Mantle Cell Lymphoma Consortium

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Patients with mantle cell lymphoma (MCL) exhibit a wide variation in clinical presentation and outcome. However, the commonly used prognostic models are outdated and inadequate to address the needs of the current multidisciplinary management of this disease. This study aims to investigate the clinical and pathological features of MCL in the immunochemotherapy era and improve the prognostic models for a more accurate prediction of patient outcomes. Methods The North American Mantle Cell Lymphoma Project is a multi-institutional collaboration of 23 institutions across North America to evaluate and refine prognosticators for front-line therapy. A total of 586 MCL cases diagnosed between 2000 and 2012 are included in this study. A comprehensive retrospective analysis was performed on the clinicopathological features, treatment approaches, and outcomes of these cases. The establishment of novel prognostic models was based on in-depth examination of baseline parameters, and subsequent validation in an independent cohort of MCL cases. Results In front-line strategies, the use of hematopoietic stem cell transplantation was the most significant parameter affecting outcomes, for both overall survival (OS, p

Published
2023
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20. TCEP: Transitions in Operator Placement to Adapt to Dynamic Network Environments

Author

Luthra, Manisha, Koldehofe, Boris, Danger, Niels, Weisenburger, Pascal, Salvaneschi, Guido, and Stavrakakis, Ioannis

Subjects
Computer Science - Distributed, Parallel, and Cluster Computing, Computer Science - Databases
Abstract

Distributed Complex Event Processing (DCEP) is a commonly used paradigm to detect and act on situational changes of many applications, including the Internet of Things (IoT). DCEP achieves this using a simple specification of analytical tasks on data streams called operators and their distributed execution on a set of infrastructure. The adaptivity of DCEP to the dynamics of IoT applications is essential and very challenging in the face of changing demands concerning Quality of Service. In our previous work, we addressed this issue by enabling transitions, which allow for the adaptive use of multiple operator placement mechanisms. In this article, we extend the transition methodology by optimizing the costs of transition and analyzing the behaviour using multiple operator placement mechanisms. Furthermore, we provide an extensive evaluation on the costs of transition imposed by operator migrations and learning, as it can inflict overhead on the performance if operated uncoordinatedly., Comment: Accepted for publication in Journal of Computer and System Sciences, Special Issue on Algorithmic Theory of Dynamic Networks and its Application

Published
2021
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24. MYC overexpression in natural killer cell lymphoma: prognostic and therapeutic implications

Author

Chengfeng Bi, Yuhua Huang, Roshia Ali, Fang Wang, Xia Yang, Alyssa Bouska, Lu Xu, Xinbao Hao, Matthew A. Lunning, Wing C. Chan, Javeed Iqbal, Dennis D. Weisenburger, Julie M. Vose, and Kai Fu

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

The current clinical management of Extranodal NK/T-cell lymphoma (ENKTL) primarily depends on conventional chemotherapy and radiotherapy, underscoring the need for innovative therapeutic strategies. This study explores the clinical significance and therapeutic implication of c-MYC (MYC) in ENKTL. Initially, we identified MYC protein overexpression in approximately 75% of cases within a large cohort of 111 patients. MYC overexpression was strongly correlated with lymphoma cell proliferation and poor clinical outcomes. Intriguingly, integrating MYC expression into the PINK-E prognostic model significantly enhanced its predictive power. Subsequently, we implemented MYC knockdown (KD) in NK malignancy cell lines with MYC overexpression, resulting in significant viability reduction. RNA-sequencing (RNA-seq) used to determine MYC function revealed a high overlap with canonical MYC-regulated genes and enrichment in metabolism and cell cycle regulation. Integrative analysis of the RNA-seq data upon MYC KD with gene expression profiles of primary ENKTL cases identified a subset of genes closely associated with MYC overexpression. Among these, CDK4 emerged as a potential therapeutic target, and its inhibition not only abrogated MYC function but also decreased MYC expression in NK malignancy cells. Furthermore, the clinical-grade CDK4/6 inhibitor palbociclib exhibited a potent anti-tumor effect in xenograft mouse models, especially when combined with gemcitabine. In summary, our study firmly establishes MYC as an oncogene with prognostic significance in ENKTL and highlights CDK4 inhibition as a promising therapeutic strategy for treating ENKTL with MYC overexpression.

Published
2024
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25. Effects of a proprietary mixture of extracts from Sabal serrulata fruits and Urtica dioica roots (WS® 1541) on prostate hyperplasia and inflammation in rats and human cells

Author

Carla Sens-Albert, Sabrina Weisenburger, Beatrix C. König, Silas F. Melcher, Ulrike A. M. Scheyhing, Karin Rollet, Philippe Lluel, Egon Koch, Martin D. Lehner, and Martin C. Michel

Subjects
Sabal serrulata, Urtica dioica, WS® 1541, PRO 160/120, benign prostate hyperplasia, BPH-1 cells, Therapeutics. Pharmacology, RM1-950
Abstract

Introduction: Phytotherapeutics, particularly extracts from Sabal serrulata (saw palmetto) fruit or Urtica dioica (stinging nettle) root, are popular for the treatment of male lower urinary symptoms in many countries, but their mechanism of action is poorly understood. We performed in vivo and in vitro studies to obtain deeper insight into the mechanism of action of WS® 1541, a proprietary combination of a Sabal serrulata fruit and an Urtica dioica root extract (WS® 1473 and WS® 1031, respectively) and its components.Methods: We used the sulpiride model of benign prostatic hyperplasia in rats and tested three doses of WS® 1541 in comparison to finasteride, evaluating weight of prostate and its individual lobes as well as aspects of inflammation, oxidative stress, growth and hyperplasia. In human BPH-1 cells, we studied the effect of WS® 1473, WS® 1031, WS® 1541 and finasteride on apoptosis, cell cycle progression and migrative capacity of the cells.Results: WS® 1541 did not reduce prostate size in sulpiride treated rats but attenuated the sulpiride-induced changes in expression of most analyzed genes and of oxidized proteins and abrogated the epithelial thickening. In vitro, WS® 1473 and WS® 1031 showed distinct profiles of favorable effects in BPH-1 cells including anti-oxidative, anti-proliferative and pro-apoptotic effects, as well as inhibiting epithelial-mesenchymal-transition.Conclusion: This data supports a beneficial effect of the clinically used WS® 1541 for the treatment of lower urinary tract symptoms associated with mild to moderate benign prostate syndrome and provides a scientific rationale for the combination of its components WS® 1473 and WS® 1031.

Published
2024
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26. Protocol for venoarterial ExtraCorporeal Membrane Oxygenation to reduce morbidity and mortality following bilateral lung TransPlantation: the ECMOToP randomised controlled trial

Author

Richard Galliot, Jonathan Messika, Jérôme Devaquet, Jérome Ridolfo, Hervé Mal, Séverine Feuillet, François Tronc, Pascal-Alexandre Thomas, Edouard Sage, Philippe Montravers, Jacques Jougon, Elodie Blanchard, Enora Atchade, Philippine Eloy, Bruno Pastene, Nassima Si Mohammed, Pierre Gazengel, Charles Cerf, David Boulate, Justin Issard, Elie Fadel, Olaf Mercier, Brice Lortat-Jacob, Sylvain Jean-Baptiste, Aurelie Snauwaert, Yves Castier, Elie Kantor, Sandrine Boudinet, Pierre Mordant, Antoine Girault, Arnaud Roussel, Aude Charvet, Julien Fessler, Philippe Lacoste, Philippe Portran, Hadrien Roze, Jacques Thes, Mickael Vourc'h, Pierre Cerceau, Vincent Bunel, Isabelle Pavlakovic, Delphine Chesnel, Léa Didier, Matthias Jacquet Lagreze, Eva Chatron, Claire Merveilleux Du Vignaux, Gabrielle Drevet, Jean Michel Maury, Valentin Soldea, Xavier Demant, Julie Macey, Christelle Pellerin, Clément Boisselier, Claire Bon, Benjamin Chevalier, Eloïse Gallo, Benjamin Repusseau, Arnaud Rodriguez, Regisse Seramondi, Matthieu Thumerel, Gaelle Dauriat, Amélie Delaporte, Samuel Dolidon, Jerome Estephan, Sylvain Diop, Dominique Fabre, Avit Guirimand, Iolanda Ion, Christian Ionescu, Jérome Le Pavec, Chahine Medraoui, Jean-Baptiste Menager, Delphine Mitilian, Andy Musat, Marwan Nader, Geoffrey Brioude, Xavier Djourno, Ambroise Labarriere, Pierre Mora, Adrien Rivory, Julien Cadiet, Nicolas Groleau, Thierry Lepoivre, Antoine Roux, Sandra de Miranda, Clément Picard, Laurence Beaumont, Olivier Brugière, Sylvie Colin de Verdière, Abdul-Momen Hamid, François Parquin, Amer Hamdan, Benjamin Zuber, Guillaume Tachon, Nicolas Mayenco-Cardenal, Mathilde Phillips-Houlbracq, David Cortier, Johanna Cohen, Alexis Paternot, Ciprian Pricopi, Francesco Cassiano, Matthieu Glorion, Julien De Wolf, Chloé Mimbimi, Morgan Le Guen, Virginie Dumans, Sébastien Jacqmin, Michael Finet, Sindia Goncalves, Louis Grosz, Charles Hickel, Julien Josserand, Julien Richard, and Gaëlle Weisenburger

Subjects
Medicine
Abstract

Introduction Lung transplantation (LTx) aims at improving survival and quality of life for patients with end-stage lung diseases. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is used as intraoperative support for LTx, despite no precise guidelines for its initiation. We aim to evaluate two strategies of VA-ECMO initiation in the perioperative period in patients with obstructive or restrictive lung disease requiring bilateral LTx. In the control ‘on-demand’ arm, high haemodynamic and respiratory needs will dictate VA-ECMO initiation; in the experimental ‘systematic’ arm, VA-ECMO will be pre-emptively initiated. We hypothesise a ‘systematic’ strategy will increase the number of ventilatory-free days at day 28.Methods and analysis We designed a multicentre randomised controlled trial in parallel groups. Adult patients with obstructive or restrictive lung disease requiring bilateral LTx, without a formal indication for pre-emptive VA-ECMO before LTx, will be included. Patients with preoperative pulmonary hypertension with haemodynamic collapse, ECMO as a bridge to transplantation, severe hypoxaemia or hypercarbia will be secondarily excluded. In the systematic group, VA-ECMO will be systematically implanted before the first pulmonary artery cross-clamp. In the on-demand group, VA-ECMO will be implanted intraoperatively if haemodynamic or respiratory indices meet preplanned criteria. Non-inclusion, secondary exclusion and VA-ECMO initiation criteria were validated by a Delphi process among investigators. Postoperative weaning of ECMO and mechanical ventilation will be managed according to best practice guidelines. The number of ventilator-free days at 28 days (primary endpoint) will be compared between the two groups in the intention-to-treat population. Secondary endpoints encompass organ failure occurrence, day 28, day 90 and year 1 vital status, and adverse events.Ethics and dissemination The sponsor is the Assistance Publique–Hôpitaux de Paris. The ECMOToP protocol version 2.1 was approved by Comité de Protection des Personnes Ile de France VIII. Results will be published in international peer-reviewed medical journals.Trial registration number NCT05664204.

Published
2024
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27. Mononeuritis multiplex following immune checkpoint inhibitors in malignant pleural mesothelioma

Author

Antonio Farina, Manon Escalere, Matthias Dion, Martin Moussy, Antoine Pegat, Macarena Villagrán-García, Perrine Devic, Anaïde Lamiral, Antoine Seyve, Karine Aure, Adrien Wang, Lucas Gorza, Nathalie Streichenberger, Thierry Maisonobe, Jerome Honnorat, Cristina Birzu, Dimitri Psimaras, David Weisenburger-Lile, and Bastien Joubert

Subjects
vasculitic neuropathy, nerve vasculitis, mononeuritis multiplex, immune checkpoint inhibitor, neurological toxicity, neurological immune-related adverse events, Neurology. Diseases of the nervous system, RC346-429
Abstract

IntroductionMononeuritis multiplex is frequently related to vasculitic neuropathy and has been reported only sporadically as an adverse event of immune checkpoint inhibitors.MethodsCase series of three patients with mononeuritis multiplex—all with mesothelioma—identified in the databases of two French clinical networks (French Reference Center for Paraneoplastic Neurological Syndromes, Lyon; OncoNeuroTox, Paris; January 2015–October 2022) set up to collect and investigate n-irAEs on a nationwide level.ResultsThree patients (male; median age 86 years; range 72–88 years) had pleural mesothelioma and received 10, 4, and 6 cycles, respectively, of first-line nivolumab plus ipilimumab combined therapy. In patient 1, the neurological symptoms involved the median nerves, and in the other two patients, there was a more diffuse distribution; the symptoms were severe (common terminology criteria for adverse events, CTCAE grade 3) in all patients. Nerve conduction studies indicated mononeuritis multiplex in all patients. Peripheral nerve biopsy demonstrated necrotizing vasculitis in patients 1 and 3 and marked IgA deposition without inflammatory lesions in patient 2. Immune checkpoint inhibitors were permanently withdrawn, and corticosteroids were administered to all patients, leading to complete symptom regression (CTCAE grade 0, patient 2) or partial improvement (CTCAE grade 2, patients 1 and 3). During steroid tapering, patient 1 experienced symptom recurrence and spreading to other nerve territories (CTCAE grade 3); he improved 3 months after rituximab and cyclophosphamide administration.DiscussionWe report the occurrence of mononeuritis multiplex, a very rare adverse event of immune checkpoint inhibitors, in the three patients with mesothelioma. Clinicians must be aware of this severe, yet treatable adverse event.

Published
2024
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28. Implementing a Language for Distributed Systems: Choices and Experiences with Type Level and Macro Programming in Scala

Author

Weisenburger, Pascal and Salvaneschi, Guido

Subjects
Computer Science - Programming Languages
Abstract

Multitier programming languages reduce the complexity of developing distributed systems by developing the distributed system in a single coherent code base. The compiler or the runtime separate the code for the components of the distributed system, enabling abstraction over low level implementation details such as data representation, serialization and network protocols. Our ScalaLoci language allows developers to declare the different components and their architectural relation at the type level, allowing static reasoning about about distribution and remote communication and guaranteeing static type safety across components. The compiler splits the multitier program into the component-specific code and automatically generates the communication boilerplate. Communication between components can be modeled by declaratively specifying data flows between components using reactive programming. In this paper, we report on the implementation of our design and our experience with embedding our language features into Scala as a host language. We show how a combination of Scala's advanced type level programming and its macro system can be used to enrich the language with new abstractions. We comment on the challenges we encountered and the solutions we developed for our current implementation and outline suggestions for an improved macro system to support the such use cases of embedding of domain-specific abstractions.

Published
2020
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29. Integrative analysis of clinicopathological features defines novel prognostic models for mantle cell lymphoma in the immunochemotherapy era: a report from The North American Mantle Cell Lymphoma Consortium

Author

Vose, Julie M., Fu, Kai, Wang, Lu, Mansoor, Adnan, Stewart, Douglas, Cheng, Hongxia, Smith, Lynette, Yuan, Ji, Qureishi, Hina Naushad, Link, Brian K., Cessna, Melissa H., Barr, Paul M., Kahl, Brad S., Mckinney, Matthew S., Khan, Nadia, Advani, Ranjana H., Martin, Peter, Goy, Andre H., Phillips, Tycel J., Mehta, Amitkumar, Kamdar, Manali, Crump, Michael, Pro, Barbara, Flowers, Christopher R., Jacobson, Caron A., Smith, Sonali M., Stephens, Deborah M., Bachanova, Veronika, Jin, Zhaohui, Wu, Shishou, Hernandez-Ilizaliturri, Francisco, Torka, Pallawi, Anampa-Guzmán, Andrea, Kashef, Farshid, Li, Xing, Sharma, Sunandini, Greiner, Timothy C., Armitage, James O., Lunning, Matthew, Weisenburger, Dennis D., Bociek, Robert G., Iqbal, Javeed, Yu, Guohua, and Bi, Chengfeng

Published
2023
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30. Successful Thrombectomy Improves Functional Outcome in Tandem Occlusions with a Large Ischemic Core

Author

Lapergue, Bertrand, Wang, Adrien, Consoli, Arturo, Coskun, Oguzhan, Maria, Federico Di, Pizzuto, Silvia, Sgreccia, Alessandro, Benoit, Charline, Gorza, Lucas, Weisenburger-Lile, David, Jabeur, Waliyde, Maia, Tchikviladze, Evrard, Serge, Rodesch, Georges, Blanc, Raphaël, Obadia, Michael, Desilles, Jean-Philippe, Piotin, Michel, Seners, Pierre, Smajda, Stanislas, Escalard, Simon, Maier, Benjamin, Sabben, Candice, Redjem, Hocine, Mikaelmazhigi, Adwan, Grace, Delvoye, François, Raaisi, Amira Al, Boisseau, William, Eker, Omer, Cho, Tae-Hee, Derex, Laurent, Fontaine, Julia, Mechtouff, Laura, Nighoghossian, Norbert, Ong, Elodie, Rascle, Lucie, Riva, Roberto, Turjman, Françis, Laubacher, Morgane, Beyragued, Mehdi, Berthezene, Yves, Hermier, Marc, Roxanna, Ameli, Bani-Sadr, Alexandre, Filip, Andrea, Cappucci, Matteo, Bourcier, Romain, Duport, Benjamin Daumas, Alexandre, Pierre Louis, Lenoble, Cédric, Hubertdesal, Gaalon, Solène De, Guillon, Benoît, Preterre, Cécile, Tessier, Guillaume, Lionnet, Arthur, Gory, Benjamin, Humbertjean-Selton, Lisa, Anxionnat, René, Derelle, Anne-Laure, Liao, Liang, Schmitt, Emmanuelle, Planel, Sophie, Richard, Sébastien, Mione, Gioia, Lacour, Jean-Christophe, Douarinou, Marian, Micard, Emilien, Chen, Bailiang, Audibert, Gérard, Masson, Agnès, Alb, Lionel, Beaumont, Marine, Tabarna, Adriana, Voicu, Marcela, Barthel, Grégoire, Podar, Iona, Brezeanu, Madalina, Reitter, Marie, Zhu, François, Marnat, Gaultier, Liegey, Jean-Sébastien, Briau, Pierre, Papillon, Lisa, Sibon, Igor, Barreau, Xavier, Papaxanthos, Jean, Berge, Jérome, Debruxelles, Sabrina, Olindo, Stephane, Poli, Mathilde, Renou, Pauline, Sagnier, Sharmila, Tourdias, Thomas, Courret, Thomas, Lucas, Ludovic, Milnerowicz, Malgorzata, Dargazanli, Cyril, Costalat, Vincent, Mourand, Isabelle, Arquizan, Caroline, Corti, Lucas, Adrien, Schiphorst, Ter, Federico, Cagnazzo, Derraz, Imad, Mahmoudi, Mehdi, Lefevre, Pierre-Henri, Gascou, Grégory, Spelle, Laurent, Caroff, Jildaz, Denier, Christian, Chalumeau, Vanessa, Mihalea, Cristian, Nicolaslegris, Ozanne, Augustin, Ikka, Leon, Chassin, Olivier, Gallas, Sophie, Venditti, Laura, Marianasarov, Cortese, Jonathan, Ferre, Jean-Christophe, Vannier, Stephane, Ronziere, Thomas, Veronica Lassalle, Maria, Gauvrit, Jean-Yves, Tracol, Clément, Boustia, Abdelghani Fakhreddine, Malrain, Cécile, Beaufreton, Edouard, Lapotre, Thibault, Alias, Quentin, Hissier, Julien, Guillen, Maud, Eugene, François, Chivot, Cyril, Courselle, Audrey, Ouin, Elisa, Lamy, Chantal, Delaforge, Kevin, Fernandez, Manuel, Vial, Jérémie, Laferte, Quentin, Desdoit, Xavier, Timsit, Serge, Jourdain, Aurore, Gentric, Jean-Christophe, Ognard, Julien, Viakhireva, Irina, Coris, Jordan, Prud'hon, Sabine, Merrien, François-Mathias, Marechal, Denis, Bruguet, Marie, Rousseau, Pierre Yves, Goas, Philippe, Boulanger, Marion, Touze, Emmanuel, Vivien, Denis, Barbier, Charlotte, Schneckenburger, Romain, Salaris, Fabrizio, Cogez, Julien, Guettier, Sophie, Porte, Estelle La, Bouchart, Jean, Mounayer, Charbel, Rouchaud, Aymeric, Saleme, Suzana, Forestier, Géraud, Clarencon, Frédéric, Rosso, Charlotte, Leder, Sara, Baronnet, Flore, Crozier, Sophie, Leger, Anne, Premat, Kevin, Eimad, Shotar, Lenck, Stéphanie, Sourour, Nader, Bottin, Laure, Ghazanfari, Sam, Yger, Marion, Alamowitch, Sonia, Delorme, Stephen, Wittwer, Aymeric, Vassilev, Christine, Naggara, Olivier, Turc, Guillaume, Hassen, Wagih Ben, Kerleroux, Basile, Trystram, Denis, Rodriguez-Regent, Christine, Ozkul-Wermester, Ozlem, Papagiannaki, Chrysanthi, Massardier, Evelyne, Triquenot, Aude, Lefebvre, Margaux, Burel, Julien, Viguier, Alain, Cognard, Christophe, Januel, Anne Christine, Albucher, Jean-François, Calviere, Lionel, Olivot, Jean-Marc, Darcourt, Jean, Raposo, Nicolas, Bonneville, Fabrice, Bellanger, Guillaume, Fontaine, Louis, Tall, Philippe, Thalamas, Claire, Geerearts, Thomas, Grepon, Antoine Faurie, Bourdain, Frédéric, Bernady, Patricia, Ballan, Guillaume, Bannier, Stéphanie, Ellie, Emmanuel, Flabeau, Olivier, Potenza, Julia, Soulages, Antoine, Lagoarde-Segot, Laurent, Cailliez, Hélène, Veunac, Louis, Higue, David, Lebras, Anthony, Adam, Sarah, Pegat, Benoit, Guen, Arnaud Le, Chedeville, François, Jouan, Jérémy, Demasles, Stéphanie, Richter, Johann Sebastian, Thierry Barroso, Bruno, Dahan, Camille, Gonnet, Alexis, Hubrecht, Régis, Lepine, Zoé, Castagnet, Hélène, Marasescu, Raluca, Heck, Olivier, Cuisenier, Pauline, Detante, Olivier, Wiki, Isabelle Favre, Bonaz, Clémentine, Garambois, Katia, Legris, Loic, Kastler, Adrian, Boubagra, Kamel, Berthet, Corentin, Charara, Stéphane, Wolff, Valérie, Pop, Raoul, Quenardelle, Véronique, Lauer, Valérie, Pierre-Paul, Irène, Roxanagheoca, Trzeciak, Malwina, Moulin, Solène, Tuan, Hua Vi, Pagano, Paolo, Doucet, Alexandre, Gelmini, Christophe, Manceau, Pierrefrançois, Paiusan, Laurentiu, Serre, Isabelle, Soize, Sébastien, Phuong Nguyen, Thi Ngoc, Sahnoun, Maher, Caucheteux, Nathalie, Ferrier, Anna, Zerroug, Abderrahim, Moreno, Ricardo, Chabert, Emmanuel, Lteif, Elie, Paulineparis, Bourgois, Nathalie, Raquin, Marie, Pasco-Papon, Anne, Girot, Jean Baptiste, Lecluse, Alderic, Godard, Sophie, L'allinec, Vincent, Janot, Kevin, Bibi, Richard, Gaudron, Marie, Bretonniere, Arnaud, Annan, Mariam, Ifergan, Héloïse, Boulouis, Grégoire, Pasi, Marco, Debiais, Séverine, Molinier, Elisabeth, Wietrich, Anthony, Ruche, Valérie, Lavandier, Karine, Bejot, Yannick, Lemogne, Brivale, Ricolfi, Fédéric, Baptiste, Laura, Thouant, Pierre, Duloquin, Gaulthier, Olivier Comby, Pierre, Charbonnier, Guillaume, Bonnet, Louise, Raybaud, Nicolas, Bouamra, Benjamin, Moulin, Thierry, Biondi, Alessandra, Finitsis, Stephanos, and Mazighi, Mikael

Published
2023
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35. Exploring Decision-Making Competence in Sugar-Substitute Choices: A Cross-Disciplinary Investigation among Chemistry and Sports and Health Students

Author

Carlo Dindorf, Fabienne Weisenburger, Eva Bartaguiz, Jonas Dully, Luisa Klappenberger, Vanessa Lang, Lisa Zimmermann, Michael Fröhlich, and Johann-Nikolaus Seibert

Subjects
interdisciplinary education, evaluation-competence, cross-curricular competencies, sugar-substitutes, ChatGPT interaction, sports, Education
Abstract

Interdisciplinary teaching approaches have gained significant importance in today’s educational landscape. Among these approaches, decision-making competence plays a pivotal role by nurturing critical thinking and problem-solving skills. Focusing on the decision-making process regarding the sensibility of using sugar-substitutes, this study addresses three key questions. (1) Do chemistry and sports and health students differ in evaluation-competence? (2) What criteria do they use in evaluating the decision-making problem? (3) How do they use ChatGPT (OpenAI, San Francisco, CA, USA), an AI tool, in decision-making? Through surveys, the study revealed two evaluation-competence factors, identified decision-making criteria, and analyzed querying behavior using ChatGPT. The results revealed nuanced differences between the two student groups in the factors of evaluation-competence. While both groups showed improvements in recognizing moral dimensions and considering alternatives, chemistry students displayed enhanced abilities in establishing evaluation criteria and empathetic thinking. Furthermore, differences emerged in the criteria selected for decision-making and querying behavior, indicating varying engagement with ChatGPT. This study offers insights into enhancing interdisciplinary education and underscores the need for tailored interventions to address diverse student needs.

Published
2024
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36. Smart Street Lights and Mobile Citizen Apps for Resilient Communication in a Digital City

Author

Baumgärtner, Lars, Höchst, Jonas, Lampe, Patrick, Mogk, Ragnar, Sterz, Artur, Weisenburger, Pascal, Mezini, Mira, and Freisleben, Bernd

Subjects
Computer Science - Human-Computer Interaction, Computer Science - Computers and Society
Abstract

Currently, nearly four billion people live in urban areas. Since this trend is increasing, natural disasters or terrorist attacks in such areas affect an increasing number of people. While information and communication technology is crucial for the operation of urban infrastructures and the well-being of its inhabitants, current technology is quite vulnerable to disruptions of various kinds. In future smart cities, a more resilient urban infrastructure is imperative to handle the increasing number of hazardous situations. We present a novel resilient communication approach based on smart street lights as part of the public infrastructure. It supports people in their everyday life and adapts its functionality to the challenges of emergency situations. Our approach relies on various environmental sensors and in-situ processing for automatic situation assessment, and a range of communication mechanisms (e.g., public WiFi hotspot functionality and mesh networking) for maintaining a communication network. Furthermore, resilience is not only achieved based on infrastructure deployed by a digital city's municipality, but also based on integrating citizens through software that runs on their mobile devices (e.g., smartphones and tablets). Web-based zero-installation and platform-agnostic apps can switch to device-to-device communication to continue benefiting people even during a disaster situation. Our approach, featuring a covert channel for professional responders and the zero-installation app, is evaluated through a prototype implementation based on a commercially available street light., Comment: 2019 IEEE Global Humanitarian Technology Conference (GHTC)

Published
2019
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42. Successful thrombectomy is beneficial in patients with pre-stroke disability: Results from an international multicenter cohort study

Author

Piotin, Michel, Blanc, Raphael, Escalard, Hocine Redjem Simon, Desilles, Jean-Philippe, Delvoye, François, Smajda, Stanislas, Maier, Benjamin, Hebert, Solène, Mazighi, Mikael, Obadia, Mikael, Sabben, Candice, Seners, Pierre, Raynouard, Igor, Corabianu, Ovide, de Broucker, Thomas, Manchon, Eric, Taylor, Guillaume, Ben Maacha, Malek, Thion, Laurie-Anne, Lecler, Augustin, Savatovsky, Julien, Wang, Adrien, Evrard, Serge, Tchikviladze, Maya, Ajili, Nadia, Lapergue, Bertrand, Weisenburger-Lile, David, Gorza, Lucas, Buard, Géraldine, Coskun, Oguzhan, Consoli, Arturo, Di Maria, Federico, Rodesh, Georges, Zimatore, Sergio, Leguen, Morgan, Gratieux, Julie, Pico, Fernando, Rakotoharinandrasana, Haja, Tassan, Philippe, Poll, Roxanna, Marinier, Sylvie, Nighoghossian, Norbert, Riva, Roberto, Eker, Omer, Turjman, Francis, Derex, Laurent, Cho, Tae-Hee, Mechtouff, Laura, Lukaszewicz, Anne Claire, Philippeau, Frédéric, Cakmak, Serkan, Blanc-Lasserre, Karine, Vallet, Anne-Evelyne, Marnat, Gaultier, Gariel, Florent, Barreau, Xavier, Berge, Jérôme, Menegon, Patrice, Sibon, Igor, Lucas, Ludovic, Olindo, Stéphane, Renou, Pauline, Sagnier, Sharmila, Poli, Mathilde, Debruxelles, Sabrina, Rouanet, François, Tourdias, Thomas, Liegey, Jean-Sebastien, Briau, Pierre, Pangon, Nicolas, Bourcier, Romain, Detraz, Lili, Daumas-Duport, Benjamin, Alexandre, Pierre-Louis, Roy, Monica, Lenoble, Cédric, Desal, Hubert, Guillon, Benoît, de Gaalon, Solène, Preterre, Cécile, Gory, Benjamin, Bracard, Serge, Anxionnat, René, Braun, Marc, Derelle, Anne-Laure, Tonnelet, Romain, Liao, Liang, Zhu, François, Schmitt, Emmanuelle, Planel, Sophie, Richard, Sébastien, Humbertjean, Lisa, Mione, Gioia, Lacour, Jean-Christophe, Riou-Comte, Nolwenn, Audibert, Gérard, Voicu, Marcela, Alb, Ionel, Reitter, Marie, Brezeanu, Madalina, Masson, Agnès, Tabarna, Adriana, Podar, Iona, Macian-montoro, Francisco, Saleme, Suzanna, Mounayer, Charbel, Rouchaud, Aymeric, Costalat, Vincent, Arquizan, Caroline, Dargazanli, Cyril, Gascou, Grégory, Lefèvre, Pierre-Henri, Derraz, Imad, Riquelme, Carlos, Gaillard, Nicolas, Mourand, Isabelle, Corti, Lucas, Cagnazzo, Federico, ter Schiphorst, Adrien, Francois, Eugene, Vannier, Stéphane, Ferre, Jean-christophe, Raoult, Helene, Ronziere, Thomas, Lassale, Maria, Paya, Christophe, Gauvrit, Jean-Yves, Tracol, Clément, Langnier-Lemercier, Sophie, Samson, Yves, Rosso, Charlotte, Leger, Anne, Deltour, Sandrine, Clarencon, Frederic, Shotar, Eimad, Spelle, Laurent, Denier, Christian, Chassin, Olivier, Chalumeau, Vanessa, Caroff, Jildaz, Venditti, Laura, Naggara, Olivier, Hassen, Wagih Ben, Boulouis, Grégoire, Rodriguez-Régent, Christine, Trystram, Denis, Kerleroux, Basile, Turc, Guillaume, Domigo, Valérie, Lamy, Catherine, Birchenall, Julia, Isabel, Clothilde, Lun, François, Viguier, Alain, Cognard, Christophe, Januel, Anne Christine, Olivot, Jean-Marc, Raposo, Nicolas, Bonneville, Fabrice, Albucher, Jean François, Calviere, Lionel, Darcourt, Jean, Tall, Philippe, Bellanger, Guillaume, Fontaine, Louis, Touze, Emmanuel, Barbier, Charlotte, Schneckenburger, Romain, Boulanger, Marion, Cogez, Julien, Guettier, Sophie, Timsit, Serge, Gentric, Jean-christophe, Ognard, Julien, Merrien, Francois Mathias, Wermester, Ozlem Ozkul, Massardier, Evelyne, Papagiannaki, Chrysanthi, Bourdain, Frédéric, Bernady, Patricia, Lagoarde-Segot, Laurent, Cailliez, Hélène, Veunac, Louis, Higue, David, Wolff, Valérie, Pop, Raoul, Beaujeux, Rémi, Dan-Sorin, Mihoc, Manisor, Monica, Le Bras, Anthony, Evain, Sarah, Le Guen, Arnaud, Richter, Sebastian, Hubrecht, Regis, Demasles, Stéphanie, Barroso, Bruno, Sablot, Denis, Farouil, Geoffroy, Tardieu, Maxime, Smadja, Philippe, Aptel, Sabine, Seiler, Ian, Ducroux, Célina, Nourredine, Mikaïl, Haesebaert, Julie, Buisson, Marielle, Alesefir, Walid, Boisseau, William, Daneault, Nicole, Deschaintre, Yan, Diestro, Jose Danilo B., Eneling, Johanna, Gioia, Laura C., Iancu, Daniella, Jacquin, Grégory, Odier, Céline, Stapf, Christian, Raymond, Jean, Roy, Daniel, Weill, Alain, and Poppe, Alexandre Y.

Published
2023
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43. ECMO support as a bridge to lung transplantation is an independent risk factor for bronchial anastomotic dehiscence

Author

Enora Atchade, Mélissa Ren, Sylvain Jean-Baptiste, Alexy Tran Dinh, Sébastien Tanaka, Parvine Tashk, Brice Lortat-Jacob, Maksud Assadi, Gaelle Weisenburger, Hervé Mal, Jean Nicolas Sénémaud, Yves Castier, Christian de Tymowski, and Philippe Montravers

Subjects
Lung transplantation, Bronchial anastomotic dehiscence, Airway complications, Extra corporeal membrane oxygenation, Diseases of the respiratory system, RC705-779
Abstract

Abstract Background Airway complications are frequent after lung transplantation (LT), as they affect up to 23% of recipients. The implication of perioperative extracorporeal membrane oxygenation (ECMO) support and haemodynamic instability has never been specifically assessed. The first aim of this study was to explore the impact of perioperative ECMO support on bronchial anastomotic dehiscence (BAD) at Day 90 after LT. Methods This prospective observational monocentric study analysed BAD in all consecutive patients who underwent LT in the Bichat Claude Bernard Hospital, Paris, France, between January 2016 and May 2019. BAD visible on bronchial endoscopy and/or tomodensitometry was recorded. A univariate analysis was performed (Fisher’s exacts and Mann–Whitney tests), followed by a multivariate analysis to assess independent risk factors for BAD during the first 90 days after LT (p

Published
2022
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45. Thrombectomy for Basilar Artery Occlusion with Mild Symptoms

Author

Piotin, Michel, Blanc, Raphael, Redjem, Hocine, Escalard, Simon, Desilles, Jean-Philippe, Ciccio, Gabriele, Smajda, Stanislas, Maier, Benjamin, Hebert, Solene, Delvoye, François, Mazighi, Mikael, Obadia, Mikael, Sabben, Candice, Peres, Roxanne, Corabianu, Ovide, de Broucker, Thomas, Smadja, Didier, Alamowitch, Sonia, Ille, Olivier, Manchon, Eric, Garcia, Pierre-Yves, Taylor, Guillaume, Ben Maacha, Malek, Wang, Adrien, Evrard, Serge, Tchikviladze, Maya, Ajili, Nadia, Lapergue, Bertrand, Weisenburger, David, Gorza, Lucas, Buard, Géraldine, Coskun, Oguzhan, Consoli, Arturo, Di Maria, Federico, Rodesh, Georges, Zimatore, Sergio, Leguen, Morgan, Gratieux, Julie, Pico, Fernando, Rakotoharinandrasana, Haja, Tassan, Philippe, Poll, Roxanna, Marinier, Sylvie, Marnat, Gaultier, Gariel, Florent, Barreau, Xavier, Berge, Jérôme, Veunac, Louis, Menegon, Patrice, Sibon, Igor, Lucas, Ludovic, Olindo, Stéphane, Renou, Pauline, Sagnier, Sharmila, Poli, Mathilde, Debruxelles, Sabrina, Bourcier, Romain, Detraz, Lili, Daumas-Duport, Benjamin, Alexandre, Pierre-Louis, Roy, Monica, Lenoble, Cédric, L'allinec, Vincent, Girot, Jean-Baptiste, Desal, Hubert, Gory, Benjamin, Bracard, Serge, Anxionnat, René, Braun, Marc, Derelle, Anne-Laure, Tonnelet, Romain, Liao, Liang, Zhu, François, Schmitt, Emmanuelle, Planel, Sophie, Richard, Sébastien, Humbertjean, Lisa, Mione, Gioia, Lacour, Jean-Christophe, Bonnerot, Mathieu, Riou-Comte, Nolwenn, Costalat, Vincent, Arquizan, Caroline, Dargazanli, Cyril, Gascou, Grégory, Lefèvre, Pierre-Henri, Derraz, Imad, Riquelme, Carlos, Gaillard, Nicolas, Mourand, Isabelle, Corti, Lucas, François, Eugene, Vannier, Stéphane, Ferre, Jean-Christophe, Raoult, Helene, Ronziere, Thomas, Lassale, Maria, Paya, Christophe, Gauvrit, Jean-Yves, Tracol, Clément, Langnier-Lemercier, Sophie, Guenego, Adrien, Weisenburger-Lile, David, Ducroux, Célina, Labreuche, Julien, Aubertin, Mathilde, Benali, Amel, Guillen, Maud, Eugene, François, Walker, Gregory, Lun, Ronda, and Fahed, Robert

Published
2021
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46. Influence of composition and heating schedules on compatibility of FeCrAl alloys with high-temperature steam

Author

Tang, Chongchong, Jianu, Adrian, Steinbrueck, Martin, Grosse, Mirco, Weisenburger, Alfons, and Seifert, Hans Juergen

Subjects
Condensed Matter - Materials Science
Abstract

FeCrAl alloys are proposed and being intensively investigated as alternative accident tolerant fuel (ATF) cladding for nuclear fission application. Herein, the influence of major alloy elements (Cr and Al), reactive element effect and heating schedules on the oxidation behavior of FeCrAl alloys in steam up to 1500{\deg}C was examined. In case of transient ramp tests, catastrophic oxidation, i.e. rapid and complete consumption of the alloy, occurred during temperature ramp up to above 1200{\deg}C for specific alloys. The maximum compatible temperature of FeCrAl alloys in steam increases with raising Cr and Al content, decreasing heating rates during ramp period and doping of yttrium. Isothermal oxidation resulted in catastrophic oxidation at 1400{\deg}C for all examined alloys. However, formation of a protective alumina scale at 1500{\deg}C was ascertained despite partial melting. The occurrence of catastrophic oxidation seems to be controlled by dynamic competitive mechanisms between mass transfer of Al from the substrate and transport of oxidizing gas through the scale both toward the metal/oxide scale interface., Comment: Submitted to Journal of nuclear materials, accepted recently

Published
2018
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47. A guide to emerging technologies for large-scale and whole brain optical imaging of neuronal activity

Author

Weisenburger, Siegfried and Vaziri, Alipasha

Subjects
Physics - Biological Physics, Physics - Optics
Abstract

The mammalian brain is a densely interconnected network that consists of millions to billions of neurons. Decoding how information is represented and processed by this neural circuitry requires the ability to capture and manipulate the dynamics of large populations at high speed and resolution over a large area of the brain. While there has been a rapid increase in use of optical approaches in the neuroscience community over the last two decades, most microscopy approaches lack the ability to record the activity of all neurons comprising a functional network across the mammalian brain at relevant temporal and spatial resolution. In this review, we survey the recent development in the optical calcium imaging technologies in this regard and provide an overview of the strengths and limitations of each modality and their potential for scalability. We provide a guidance from a biological user perspective that is driven by the typical biological applications and sample conditions. We also discuss the potential for future advances and synergies that could be obtained through hybrid approaches or other modalities., Comment: 21 pages, 5 figures

Published
2018
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50. DNMT3A mutations define a unique biological and prognostic subgroup associated with cytotoxic T cells in PTCL-NOS

Author

Herek, Tyler A., Bouska, Alyssa, Lone, Waseem, Sharma, Sunandini, Amador, Catalina, Heavican, Tayla B., Li, Yuping, Wei, Qi, Jochum, Dylan, Greiner, Timothy C., Smith, Lynette, Pileri, Stefano, Feldman, Andrew L., Rosenwald, Andreas, Ott, German, Lim, Soon Thye, Ong, Choon Kiat, Song, Joo, Jaffe, Elaine S., Wang, Gang Greg, Staudt, Louis, Rimsza, Lisa M., Vose, Julie, d'Amore, Francesco, Weisenburger, Dennis D., Chan, Wing C., and Iqbal, Javeed

Published
2022
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