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437 results on '"Weisberg E"'

1. Contraception and endometriosis: challenges, efficacy, and therapeutic importance

Author

Weisberg E and Fraser IS

Subjects
Gynecology and obstetrics, RG1-991
Abstract

Edith Weisberg,1 Ian S Fraser2 1Family Planning NSW, 2School of Women's and Children's Health, University of New South Wales, Sydney, NSW, Australia Abstract: Endometriosis is a benign gynecological condition that is estimated to affect 10% of women in the general population and appears to be increasing in incidence. It is an estrogen-dependent inflammatory disease, and is primarily characterized by dysmenorrhea, deep dyspareunia, chronic pelvic pain, and variable effects on fertility. The symptoms may greatly affect quality of life, and symptom control may be the primary aim of initial management, while contraceptive effect is often secondary. It is estimated that 30%–50% of women with endometriosis have an infertility problem, so a considerable number of endometriosis sufferers will require effective, planned contraception to maximize “protection of fertility” and prevent progression of the endometriotic condition. Ideally, this contraception should also provide symptom relief and improvement of physical, mental, and social well-being. At the present time, long-term progestogens appear to be the most effective choice for meeting all of these requirements, but other options need to be considered. It is becoming increasingly recognized that hormonal contraceptive systems are necessary for prevention of disease recurrence following surgical treatment of endometriosis. The personal preferences of the woman are an integral part of the final contraceptive choice. This article discusses the advantages and disadvantages of the contraceptive options available to women with endometriosis. Keywords: pelvic pain, disease recurrence, progestogens, delivery systems, long-acting

Published
2015

2. A chewable low-dose oral contraceptive: a new birth control option?

Author

Weisberg E

Subjects
Medicine (General), R5-920
Abstract

Edith Weisberg1,21Sydney Centre for Reproductive Health Research, Research Division of Family Planning NSW, 2Department of Obstetrics and Gynaecology, Queen Elizabeth II Research Institute for Mothers and Infants, University of Sydney, Sydney, AustraliaAbstract: A new chewable combined oral contraceptive pill containing ethinyl estradiol (EE) 0.025 mg and norethindrone (NE) 0.8 mg in a 24/4 regimen was approved for marketing in December 2010. Each of the four inactive tablets contains 75 mg ferrous fumarate, which has no therapeutic benefit. The tablet can be taken with food but not water as this affects the absorption of EE. The Pearl index based on intention to treat women aged 18–35 years has been reported at 2.01 (confidence interval [CI] 1.21, 3.14) and for the whole population 1.65 (CI 1.01, 2.55). The effect of a body mass index of >35 was not studied. Regular withdrawal bleeding occurred for 78.6% of women in Cycle 1, but by Cycle 13 almost half the women failed to have a withdrawal bleed. This new formulation provides an intermediate dose of an EE/NE combination that will be useful for women experiencing breakthrough bleeding on the lower-dose EE/NE pill. The convenience of a low-dose pill, which can be chewed without the need for water, will be useful to enable women who have forgotten a pill to take one whenever they remember, provided they carry it with them. The advantage of a 24/4 regimen is better suppression of follicular development in the pill-free interval and may be beneficial for women who experience menstrual cycle-related problems, such as heavy bleeding or dysmenorrhea.Keywords: combined oral contraceptive, low dose, ethinyl estradiol, norethindrone

Published
2012

7. Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemia

Author

Wu, H, Hu, C, Wang, A, Weisberg, E L, Chen, Y, Yun, C-H, Wang, W, Liu, Y, Liu, X, Tian, B, Wang, J, Zhao, Z, Liang, Y, Li, B, Wang, L, Wang, B, Chen, C, Buhrlage, S J, Qi, Z, Zou, F, Nonami, A, Li, Y, Fernandes, S M, Adamia, S, Stone, R M, Galinsky, I A, Wang, X, Yang, G, Griffin, J D, Brown, J R, Eck, M J, Liu, J, Gray, N S, and Liu, Q

Published
2016
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18. Australian medicine 1996/1997

Author

Johnston, CI, Eadie, MJ, Cooper, DA, Carroll, G, Dwyer, DE, Katelaris, P, De Launey, J, Cousins, M, Selby, W, Simons, L, Mitchell, P, Donovan, B, Quirk, CJ, and Weisberg, E

Published
1996

27. Spotlight on midostaurin in the treatment of FLT3-mutated acute myeloid leukemia and systemic mastocytosis: design, development, and potential place in therapy

Author

Weisberg E, Sattler M, Manley PW, and Griffin JD

Subjects
midostaurin, AML, hemic and lymphatic diseases, embryonic structures, hemic and immune systems, acute myeloid leukemia, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, PKC412, lcsh:RC254-282
Abstract

Ellen Weisberg,1,2 Martin Sattler,1,2 Paul W Manley,3 James D Griffin1,2 1Department of Medical Oncology, Dana-Farber Cancer Institute, 2Department of Medicine, Harvard Medical School, Boston, MA, USA; 3Department of Oncology, Novartis Institutes of Biomedical Research, Basel, Switzerland Abstract: The Fms-like tyrosine kinase-3 (FLT3; fetal liver kinase-2; human stem cell tyrosine kinase-1; CD135) is a class III receptor tyrosine kinase that is normally involved in regulating the proliferation, differentiation, and survival of both hematopoietic cells and dendritic cells. Mutations leading it to be constitutively activated make it an oncogenic driver in ~30% of acute myeloid leukemia (AML) patients where it is associated with poor prognosis. The prevalence of oncogenic FLT3 and the dependency on its constitutively activated kinase activity for leukemia growth make this protein an attractive target for therapeutic intervention. Of the numerous small molecule inhibitors under clinical investigation for the treatment of oncogenic FLT3-positive AML, the N-benzoyl-staurosporine, midostaurin (CGP41251; PKC412; Rydapt®; Novartis Pharma AG, Basel, Switzerland), is the first to be approved by the US Food and Drug Administration for the treatment, in combination with standard chemotherapy, of newly diagnosed adult AML patients who harbor mutations in FLT3. Here, we describe the early design of midostaurin, the preclinical discovery of its activity against oncogenic FLT3, and its subsequent clinical development as a therapeutic agent for FLT3 mutant-positive AML. Keywords: AML, acute myeloid leukemia, PKC412, midostaurin, FLT3-ITD, oncogenic FLT3, targeted therapy

Published
2017

36. Consideration Sets and Their Role in Modelling Doctor Recommendations About Contraceptives

Author

Fiebig, DG, Viney, R, Knox, S, Haas, M, Street, DJ, Hole, AR, Weisberg, E, and Bateson, D

Subjects
Adult, Contraception, Reproductive Health, Contraceptive Agents, Adolescent, Physicians, education, Health Policy & Services, Humans, Female, Choice Behavior, Referral and Consultation
Abstract

Copyright © 2015 John Wiley & Sons, Ltd. Decisions about prescribed contraception are typically the result of a consultation between a woman and her doctor. In order to better understand contraceptive choice within this environment, stated preference methods are utilized to ask doctors about what contraceptive options they would discuss with different types of women. The role of doctors is to confine their discussion to a subset of products that best match their patient. This subset of options forms the consideration set from which the ultimate recommendation is made. Given the existence of consideration sets we address the issue of how to model appropriately the ultimate recommendations. The estimated models enable us to characterize doctor recommendations and how they vary with patient attributes and to highlight where recommendations are clear and when they are uncertain. The results also indicate systematic variation in recommendations across different types of doctors, and in particular we observe that some doctors are reluctant to embrace new products and instead recommend those that are more familiar. Such effects are one possible explanation for the relatively low uptake of more cost effective longer acting reversible contraceptives and indicate that further education and training of doctors may be warranted. Copyright © 2015 John Wiley & Sons, Ltd.

Published
2017

40. A Review of the Literature of: 1960, on Wastewater and Water Pollution Control

Author

Heukelekian, H., Manganelli, R. M., Alspaugh, T. A., Berg, E. J., Clark, H. F., Connell, C. H., Dobbins, W. E., Edwards, G. P., Ettinger, M. B., Foulke, D. G., Furman, T. deS., Gaffney, P. E., Gellman, I., Harding, H. G., Helwig, J. D., Hoak, R. D., Ingols, R. S., Ingram, W. M., Kabler, P. W., Katz, M., Kittrell, F. W., Lardieri, N. J., Luley, H. G., McGauhey, P. H., Porges, R., Steffen, A. J., Straub, C., Tarzwell, C. M., Teletzke, G. H., Towne, W. W., Trebler, H. A., Tsivoglou, E. C., Weisberg, E., and Woodward, R. L.

Published
1961

41. Analytical Methods

Author

Heukelekian, H., Manganelli, R. M., Berg, E. J., Clark, H. F., Connell, C. H., Dobbins, W. E., Edwards, G. P., Ettinger, M. B., Foulke, D. G., Furman, T. deS., Gellman, I., Harding, H., Henderson, C., Hoak, R. D., Gaffney, P. E., Ingram, W. M., Kabler, P. W., Katz, M., Kittrell, F. W., Lardieri, N. J., Luley, H. G., McGauhey, P. H., Moore, W. A., Nemerow, N. L., Porges, R., Roth, E. R., Steffen, A. J., Straub, C., Tarzwell, C. M., Towne, W. W., Trebler, H. A., Tsivoglou, E. C., Weisberg, E., and Woodward, R. L.

Published
1960

43. Sewage

Author

Heukelekian, H., Manganelli, R. M., Berg, E. J., Clark, H. F., Connell, C. H., Dobbins, W. E., Edwards, G. P., Ettinger, M. B., Foulke, D. G., Furman, T. deS., Gellman, I., Harding, H., Henderson, C., Hoak, R. D., Gaffney, P. E., Ingram, W. M., Kabler, P. W., Katz, M., Kittrell, F. W., Lardieri, N. J., Luley, H. G., McGauhey, P. H., Moore, W. A., Nemerow, N. L., Porges, R., Roth, E. R., Steffen, A. J., Straub, C., Tarzwell, C. M., Towne, W. W., Trebler, H. A., Tsivoglou, E. C., Weisberg, E., and Woodward, R. L.

Published
1960

44. Industrial Wastes-Radioactive

Author

Heukelekian, H., Manganelli, R. M., Berg, E. J., Clark, H. F., Connell, C. H., Dobbins, W. E., Edwards, G. P., Ettinger, M. B., Foulke, D. G., Furman, T. deS., Gellman, I., Harding, H., Henderson, C., Hoak, R. D., Gaffney, P. E., Ingram, W. M., Kabler, P. W., Katz, M., Kittrell, F. W., Lardieri, N. J., Luley, H. G., McGauhey, P. H., Moore, W. A., Nemerow, N. L., Porges, R., Roth, E. R., Steffen, A. J., Straub, C., Tarzwell, C. M., Towne, W. W., Trebler, H. A., Tsivoglou, E. C., Weisberg, E., and Woodward, R. L.

Published
1960

45. Water Pollution

Author

Heukelekian, H., Manganelli, R. M., Berg, E. J., Clark, H. F., Connell, C. H., Dobbins, W. E., Edwards, G. P., Ettinger, M. B., Foulke, D. G., Furman, T. deS., Gellman, I., Harding, H., Henderson, C., Hoak, R. D., Gaffney, P. E., Ingram, W. M., Kabler, P. W., Katz, M., Kittrell, F. W., Lardieri, N. J., Luley, H. G., McGauhey, P. H., Moore, W. A., Nemerow, N. L., Porges, R., Roth, E. R., Steffen, A. J., Straub, C., Tarzwell, C. M., Towne, W. W., Trebler, H. A., Tsivoglou, E. C., Weisberg, E., and Woodward, R. L.

Published
1960

46. Industrial Wastes

Author

Heukelekian, H., Manganelli, R. M., Berg, E. J., Clark, H. F., Connell, C. H., Dobbins, W. E., Edwards, G. P., Ettinger, M. B., Foulke, D. G., Furman, T. deS., Gellman, I., Harding, H., Henderson, C., Hoak, R. D., Gaffney, P. E., Ingram, W. M., Kabler, P. W., Katz, M., Kittrell, F. W., Lardieri, N. J., Luley, H. G., McGauhey, P. H., Moore, W. A., Nemerow, N. L., Porges, R., Roth, E. R., Steffen, A. J., Straub, C., Tarzwell, C. M., Towne, W. W., Trebler, H. A., Tsivoglou, E. C., Weisberg, E., and Woodward, R. L.

Published
1960

47. A Review of the Literature of: 1961, on Wastewater and Water Pollution Control

Author

Okun, D. A., Weiss, C. M., Alspaugh, T. A., Berg, E. J., Berger, B. B., Clark, H. F., Connell, C. H., De Martini, F. E., Dobbins, W. E., Edwards, G. P., Engelbrecht, R. S., Ettinger, M. B., Foulke, D. G., Furman, T. deS., Gaffney, P. E., Gellman, I., Gloyna, E. F., Harding, H. G., Helwig, J. D., Hoak, R. D., Ingols, R. S., Ingram, W. M., Kabler, P. W., Katz, M., Kittrell, F. W., Lardieri, N. J., Luley, H. G., Lynn, W. R., McGauhey, P. H., Olds, J., Porges, R., Shuval, H., Steffen, A. J., Straub, C., Surber, E., Tarzwell, C. M., Teletzke, G. H., Towne, W. W., Trebler, H. A., Tsivoglou, E. C., Weisberg, E., and Woodward, R. L.

Published
1962

48. Industrial Wastes

Author

Heukelekian, H., Manganelli, R., Amberg, H., Berg, E. J., Clark, H. F., Connell, C. H., Dobbins, W. E., Edwards, G. P., Ettinger, M. B., Foulke, D. G., Furman, T. deS., Gellman, I., Harding, H. G., Hoak, R. D., Ingols, R. S., Ingram, W. M., Kabler, P. W., Katz, M., Kittrell, F. W., Luley, H. G., McGauhey, P. H., Moore, W. A., Porges, R., Roth, E. R., Steffen, A. J., Straub, C., Tarzwell, C. M., Teletzke, G. H., Towne, W. W., Trebler, H. A., Tsivoglou, E. C., Weisberg, E., and Woodward, R. L.

Published
1959

49. Industrial Wastes: Radioactive

Author

Heukelekian, H., Manganelli, R., Amberg, H., Berg, E. J., Clark, H. F., Connell, C. H., Dobbins, W. E., Edwards, G. P., Ettinger, M. B., Foulke, D. G., Furman, T. deS., Gellman, I., Harding, H. G., Hoak, R. D., Ingols, R. S., Ingram, W. M., Kabler, P. W., Katz, M., Kittrell, F. W., Luley, H. G., McGauhey, P. H., Moore, W. A., Porges, R., Roth, E. R., Steffen, A. J., Straub, C., Tarzwell, C. M., Teletzke, G. H., Towne, W. W., Trebler, H. A., Tsivoglou, E. C., Weisberg, E., and Woodward, R. L.

Published
1959

50. Water Pollution

Author

Heukelekian, H., Manganelli, R., Amberg, H., Berg, E. J., Clark, H. F., Connell, C. H., Dobbins, W. E., Edwards, G. P., Ettinger, M. B., Foulke, D. G., Furman, T. deS., Gellman, I., Harding, H. G., Hoak, R. D., Ingols, R. S., Ingram, W. M., Kabler, P. W., Katz, M., Kittrell, F. W., Luley, H. G., McGauhey, P. H., Moore, W. A., Porges, R., Roth, E. R., Steffen, A. J., Straub, C., Tarzwell, C. M., Teletzke, G. H., Towne, W. W., Trebler, H. A., Tsivoglou, E. C., Weisberg, E., and Woodward, R. L.

Published
1959

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