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1. Perinatal outcomes between immediate vs deferred selective termination in dichorionic twin pregnancies with fetal congenital anomalies: a French multicenter study

Author

Soussan, Stanley, Egloff, Charles, Peyronnet, Violaine, Winer, Norbert, Weingertner, Anne-Sophie, Rault, Emmanuel, Fuchs, Florent, Quibel, Thibault, Bourgon, Nicolas, Vivanti, Alexandre J., Rosenblatt, Jonathan, Ponzio-Klijanienko, Alice, Dap, Matthieu, Mandelbrot, Laurent, and Picone, Olivier

Published
2024
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3. Amniotic fluid peptides predict postnatal kidney survival in developmental kidney disease

Author

Allegaert, Karel, Aubard, Yves, Basmaison, Odile, Benevent, Jean-Baptiste, Biquard, Florence, Champion, Gérard, Delbosc, Jean-Marie, Eckart, Philippe, Froute, Marie-Françoise, Gaucherand, Pascal, Groussolles, Marion, Guigonis, Vincent, Hougas, Blandine, Le Bouar, Gwenaelle, Martin, Alain, Martin, Sophie, Maupin-Hyvonnet, Mariannick, Merveille, Marina, Mousty, Eve, Nobili, François, Ryckewaert, Amelie, Sartor, Agnes, Taque, Sophie, Winer, Norbert, Klein, Julie, Buffin-Meyer, Bénédicte, Boizard, Franck, Moussaoui, Nabila, Lescat, Ophélie, Breuil, Benjamin, Fedou, Camille, Feuillet, Guylène, Casemayou, Audrey, Neau, Eric, Hindryckx, An, Decatte, Luc, Levtchenko, Elena, Raaijmakers, Anke, Vayssière, Christophe, Goua, Valérie, Lucas, Charlotte, Perrotin, Franck, Cloarec, Sylvie, Benachi, Alexandra, Manca-Pellissier, Marie-Christine, Delmas, Hélène Laurichesse, Bessenay, Lucie, Le Vaillant, Claudine, Allain-Launay, Emma, Gondry, Jean, Boudailliez, Bernard, Simon, Elisabeth, Prieur, Fabienne, Lavocat, Marie-Pierre, Saliou, Anne-Hélène, De Parscau, Loic, Bidat, Laurent, Noel, Catherine, Floch, Corinne, Bourdat-Michel, Guylène, Favre, Romain, Weingertner, Anne-Sophie, Oury, Jean-François, Baudouin, Véronique, Bory, Jean-Paul, Pietrement, Christine, Fiorenza, Maryse, Massardier, Jérôme, Kessler, Sylvie, Lounis, Nadia, Auriol, Françoise Conte, Marcorelles, Pascale, Collardeau-Frachon, Sophie, Zürbig, Petra, Mischak, Harald, Magalhães, Pedro, Batut, Julie, Blader, Patrick, Saulnier Blache, Jean-Sebastien, Bascands, Jean-Loup, Schaefer, Franz, Decramer, Stéphane, and Schanstra, Joost P.

Published
2021
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4. Trisomy 22: First and Second Trimester Cytogenetic Analysis and Phenotypic Presentation in a Series of Seven Cases.

Author

Minella, Chris, Jeandidier, Eric, Koch, Antoine, Antal, Maria Cristina, Favre, Romain, Sananes, Nicolas, and Weingertner, Anne-Sophie

Subjects
TRISOMY, PHENOTYPES, NEWBORN infants, PLACENTA
Abstract

Introduction: Trisomy 22 is a chromosomal disorder rarely encountered prenatally. Even fewer live births are observed and generally correspond to confined placental mosaic trisomy 22, or even more uncommonly, to true fetal mosaic trisomy 22. Case Presentation: We examine and describe a series of seven cases of trisomy 22 encountered prenatally in terms of their cytogenetic and phenotypic presentations and discuss their interrelationships along with case management and outcomes. We aimed to identify aspects of prenatal data suggestive of fetal trisomy 22 and to determine whether a prognosis can be established from these factors. Conclusion: Our conclusion is that prenatal data elements can provide key elements of information to guide multidisciplinary care and support for the couple and the neonate. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Microcephaly caused by lymphocytic choriomeningitis virus

Author

Delaine, Maia, Weingertner, Anne-Sophie, Nougairede, Antoine, Lepiller, Quentin, Fafi-Kremer, Samira, Favre, Romain, and Charrel, Remi

Subjects
Viral meningitis -- Health aspects, Disease transmission -- Health aspects, Infection -- Health aspects, Pregnancy -- Health aspects, Pregnant women -- Health aspects, Health
Abstract

Lymphocytic choriomeningitis viras (LCMV) is an arenavirus, discovered by Armstrong and Lillie in 1933 (1) that chronically infects small rodents. Humans can be infected by direct contact with rodents or [...]

Published
2017
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13. Post-laser twin anemia polycythemia sequence: diagnosis, management, and outcome in an international cohort of 164 cases

Author

Tollenaar, Lisanne L.S.A., Lopriore, Enrico, Faiola, Stefano, Lanna, Mariano, Stirnemann, Julien, Ville, Yves, Lewi, Liesbeth, Devlieger, Roland, Weingertner, Anne Sophie, Favre, Romain, Hobson, Sebastian Rupert, Ryan, Greg, Rodó, Carlota, Arévalo, Silvia, Klaritsch, Philipp, Greimel, Patrick, Hecher, Kurt, de Sousa, Manuela Tavares, Khalil, Asma, Thilaganathan, Basky, Bergh, Eric E.P., Papanna, Ramesha, Gardener, Glenn G.J., Carlin, Andrew, Bevilacqua, Elisa, Sakalo, Victoria Aleksey, Kostyukov, Kirill K.V., Bahtiyar, Mert Ozan, Wilpers, Abigail, Kilby, Mark M.D., Tiblad, Eleonor, Oepkes, Dick, Middeldorp, Johanna J.M., Haak, Monique Cecile, Klumper, Frans F.J.C.M., Akkermans, Joost, Slaghekke, Femke, Tollenaar, Lisanne L.S.A., Lopriore, Enrico, Faiola, Stefano, Lanna, Mariano, Stirnemann, Julien, Ville, Yves, Lewi, Liesbeth, Devlieger, Roland, Weingertner, Anne Sophie, Favre, Romain, Hobson, Sebastian Rupert, Ryan, Greg, Rodó, Carlota, Arévalo, Silvia, Klaritsch, Philipp, Greimel, Patrick, Hecher, Kurt, de Sousa, Manuela Tavares, Khalil, Asma, Thilaganathan, Basky, Bergh, Eric E.P., Papanna, Ramesha, Gardener, Glenn G.J., Carlin, Andrew, Bevilacqua, Elisa, Sakalo, Victoria Aleksey, Kostyukov, Kirill K.V., Bahtiyar, Mert Ozan, Wilpers, Abigail, Kilby, Mark M.D., Tiblad, Eleonor, Oepkes, Dick, Middeldorp, Johanna J.M., Haak, Monique Cecile, Klumper, Frans F.J.C.M., Akkermans, Joost, and Slaghekke, Femke

Abstract

The aim of this study was to investigate the management and outcome in the post-laser twin anemia polycythemia sequence (TAPS). Data of the international TAPS Registry, collected between 2014 and 2019, were used for this study. The primary outcomes were perinatal mortality and severe neonatal morbidity. Secondary outcomes included a risk factor analysis for perinatal mortality and severe neonatal morbidity. A total of 164 post-laser TAPS pregnancies were included, of which 92% (151/164) were diagnosed antenatally and 8% (13/164) postnatally. The median number of days between laser for TTTS and detection of TAPS was 14 (IQR: 7–28, range: 1–119). Antenatal management included expectant management in 43% (62/151), intrauterine transfusion with or without partial exchange transfusion in 29% (44/151), repeated laser surgery in 15% (24/151), selective feticide in 7% (11/151), delivery in 6% (9/151), and termination of pregnancy in 1% (1/151). The median gestational age (GA) at birth was 31.7 weeks (IQR: 28.6–33.7; range: 19.0–41.3). The perinatal mortality rate was 25% (83/327) for the total group, 37% (61/164) for donors, and 14% (22/163) for recipients (p < 0.001). Severe neonatal morbidity was detected in 40% (105/263) of the cohort and was similar for donors (43%; 51/118) and recipients (37%; 54/145), p = 0.568. Independent risk factors for spontaneous perinatal mortality were antenatal TAPS Stage 4 (OR = 3.4, 95%CI 1.4-26.0, p = 0.015), TAPS donor status (OR = 4.2, 95%CI 2.1–8.3, p < 0.001), and GA at birth (OR = 0.8, 95%CI 0.7–0.9, p = 0.001). Severe neonatal morbidity was significantly associated with GA at birth (OR = 1.5, 95%CI 1.3–1.7, p < 0.001). In conclusion, post-laser TAPS most often occurs within one month after laser for TTTS, but may develop up to 17 weeks after initial surgery. Management is mostly expectant, but varies greatly, highlighting the lack of consensus on the optimal treatment and heterogeneity of the condition. Perinatal outcome is poor, par, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2020

14. Spontaneous twin anemia polycythemia sequence: diagnosis, management, and outcome in an international cohort of 249 cases

Author

Tollenaar, Lisanne L.S.A., Slaghekke, Femke, Lewi, Liesbeth, Colmant, Claire, Lanna, Mariano, Weingertner, Anne Sophie, Ryan, Greg, Arévalo, Silvia, Klaritsch, Philipp, Tavares de Sousa, Manuela, Khalil, Asma, Papanna, Ramesha, Gardener, Glenn G.J., Bevilacqua, Elisa, Kostyukov, Kirill K.V., Bahtiyar, Mert Ozan, Kilby, Mark M.D., Tiblad, Eleonor, Oepkes, Dick, Lopriore, Enrico, Tollenaar, Lisanne L.S.A., Slaghekke, Femke, Lewi, Liesbeth, Colmant, Claire, Lanna, Mariano, Weingertner, Anne Sophie, Ryan, Greg, Arévalo, Silvia, Klaritsch, Philipp, Tavares de Sousa, Manuela, Khalil, Asma, Papanna, Ramesha, Gardener, Glenn G.J., Bevilacqua, Elisa, Kostyukov, Kirill K.V., Bahtiyar, Mert Ozan, Kilby, Mark M.D., Tiblad, Eleonor, Oepkes, Dick, and Lopriore, Enrico

Abstract

Background: Twin anemia polycythemia sequence is a chronic form of unbalanced fetofetal transfusion through minuscule placental anastomoses in monochorionic twins, leading to anemia in the donor and polycythemia in the recipient. Owing to the low incidence of twin anemia polycythemia sequence, data on diagnosis, management, and outcome are limited. Objective: This study aimed to investigate the diagnosis, management, and outcome in a large international cohort of spontaneous twin anemia polycythemia sequence. Study Design: Data from the international twin anemia polycythemia sequence registry, retrospectively collected between 2014 and 2019, were used for this study. A total of 17 fetal therapy centers contributed to the data collection. The primary outcomes were perinatal mortality and severe neonatal morbidity. Secondary outcomes included a risk factor analysis for perinatal mortality and severe neonatal morbidity. Results: A total of 249 cases of spontaneous twin anemia polycythemia sequence were included in this study, 219 (88%) of which were diagnosed antenatally and 30 (12%) postnatally. Twin anemia polycythemia sequence was diagnosed antenatally at a median gestational age of 23.7 weeks (interquartile range, 9.7–28.8; range, 15.1–35.3). Antenatal management included laser surgery in 39% (86 of 219), expectant management in 23% (51 of 219), delivery in 16% (34 of 219), intrauterine transfusion (with partial exchange transfusion) in 12% (26 of 219), selective feticide in 8% (18 of 219), and termination of pregnancy in 1% (3 of 219) of cases. Perinatal mortality rate was 15% (72 of 493) for the total group, 22% (54 of 243) for donors, and 7% (18 of 242) for recipients (P<.001). Severe neonatal morbidity occurred in 33% (141 of 432) of twins with twin anemia polycythemia sequence and was similar for donors (32%; 63 of 196) and recipients (33%; 75 of 228) (P=.628). Independent risk factors for spontaneous perinatal mortality were donor status (odds ratio, 3.8; 95%, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2020

15. Amniotic fluid peptides predict postnatal kidney survival in developmental kidney disease

Author

Klein, Julie, primary, Buffin-Meyer, Bénédicte, additional, Boizard, Franck, additional, Moussaoui, Nabila, additional, Lescat, Ophélie, additional, Breuil, Benjamin, additional, Fedou, Camille, additional, Feuillet, Guylène, additional, Casemayou, Audrey, additional, Neau, Eric, additional, Hindryckx, An, additional, Decatte, Luc, additional, Levtchenko, Elena, additional, Raaijmakers, Anke, additional, Vayssière, Christophe, additional, Goua, Valérie, additional, Lucas, Charlotte, additional, Perrotin, Franck, additional, Cloarec, Sylvie, additional, Benachi, Alexandra, additional, Manca-Pellissier, Marie-Christine, additional, Delmas, Hélène Laurichesse, additional, Bessenay, Lucie, additional, Le Vaillant, Claudine, additional, Allain-Launay, Emma, additional, Gondry, Jean, additional, Boudailliez, Bernard, additional, Simon, Elisabeth, additional, Prieur, Fabienne, additional, Lavocat, Marie-Pierre, additional, Saliou, Anne-Hélène, additional, De Parscau, Loic, additional, Bidat, Laurent, additional, Noel, Catherine, additional, Floch, Corinne, additional, Bourdat-Michel, Guylène, additional, Favre, Romain, additional, Weingertner, Anne-Sophie, additional, Oury, Jean-François, additional, Baudouin, Véronique, additional, Bory, Jean-Paul, additional, Pietrement, Christine, additional, Fiorenza, Maryse, additional, Massardier, Jérôme, additional, Kessler, Sylvie, additional, Lounis, Nadia, additional, Auriol, Françoise Conte, additional, Marcorelles, Pascale, additional, Collardeau-Frachon, Sophie, additional, Zürbig, Petra, additional, Mischak, Harald, additional, Magalhães, Pedro, additional, Batut, Julie, additional, Blader, Patrick, additional, Saulnier Blache, Jean-Sebastien, additional, Bascands, Jean-Loup, additional, Schaefer, Franz, additional, Decramer, Stéphane, additional, Schanstra, Joost P., additional, Allegaert, Karel, additional, Aubard, Yves, additional, Basmaison, Odile, additional, Benevent, Jean-Baptiste, additional, Biquard, Florence, additional, Champion, Gérard, additional, Delbosc, Jean-Marie, additional, Eckart, Philippe, additional, Froute, Marie-Françoise, additional, Gaucherand, Pascal, additional, Groussolles, Marion, additional, Guigonis, Vincent, additional, Hougas, Blandine, additional, Le Bouar, Gwenaelle, additional, Martin, Alain, additional, Martin, Sophie, additional, Maupin-Hyvonnet, Mariannick, additional, Merveille, Marina, additional, Mousty, Eve, additional, Nobili, François, additional, Ryckewaert, Amelie, additional, Sartor, Agnes, additional, Taque, Sophie, additional, and Winer, Norbert, additional

Published
2021
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16. Spontaneous twin anemia polycythemia sequence: diagnosis, management, and outcome in an international cohort of 249 cases

Author

Tollenaar, Lisanne S.A., primary, Slaghekke, Femke, additional, Lewi, Liesbeth, additional, Colmant, Claire, additional, Lanna, Mariano, additional, Weingertner, Anne Sophie, additional, Ryan, Greg, additional, Arévalo, Silvia, additional, Klaritsch, Philipp, additional, Tavares de Sousa, Manuela, additional, Khalil, Asma, additional, Papanna, Ramesha, additional, Gardener, Glenn J., additional, Bevilacqua, Elisa, additional, Kostyukov, Kirill V., additional, Bahtiyar, Mert O., additional, Kilby, Mark D., additional, Tiblad, Eleonor, additional, Oepkes, Dick, additional, and Lopriore, Enrico, additional

Published
2021
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19. Fetoscopic Release of Amniotic Band Syndrome

Author

Minella, Chris, primary, Costantino, Benedicte, additional, Ruano, Rodrigo, additional, Koch, Antoine, additional, Weingertner, Anne‐Sophie, additional, Favre, Romain, additional, and Sananes, Nicolas, additional

Published
2020
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20. Ultrasound features of fetal toxoplasmosis: A contemporary multicenter survey in 88 fetuses

Author

Codaccioni, Camille, primary, Picone, Olivier, additional, Lambert, Véronique, additional, Maurice, Paul, additional, Pomar, Léo, additional, Winer, Norbert, additional, Guibaud, Laurent, additional, Lavergne, Rose‐Anne, additional, Saliou, Anne‐Hélène, additional, Quinio, Dorothée, additional, Benachi, Alexandra, additional, Noel, Catherine, additional, Ville, Yves, additional, Cuillier, Fabrice, additional, Pomares, Christelle, additional, Ferret, Nicole, additional, Filisetti, Denis, additional, Weingertner, Anne‐Sophie, additional, Vequeau‐Goua, Valérie, additional, Cateau, Estelle, additional, Benoist, Guillaume, additional, Wallon, Martine, additional, Dommergues, Marc, additional, Villena, Isabelle, additional, and Mandelbrot, Laurent, additional

Published
2020
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21. Post-Laser Twin Anemia Polycythemia Sequence: Diagnosis, Management, and Outcome in an International Cohort of 164 Cases

Author

Tollenaar, Lisanne S.A., primary, Lopriore, Enrico, additional, Faiola, Stefano, additional, Lanna, Mariano, additional, Stirnemann, Julien, additional, Ville, Yves, additional, Lewi, Liesbeth, additional, Devlieger, Roland, additional, Weingertner, Anne Sophie, additional, Favre, Romain, additional, Hobson, Sebastian R., additional, Ryan, Greg, additional, Rodo, Carlota, additional, Arévalo, Silvia, additional, Klaritsch, Philipp, additional, Greimel, Patrick, additional, Hecher, Kurt, additional, de Sousa, Manuela Tavares, additional, Khalil, Asma, additional, Thilaganathan, Basky, additional, Bergh, Eric P., additional, Papanna, Ramesha, additional, Gardener, Glenn J., additional, Carlin, Andrew, additional, Bevilacqua, Elisa, additional, Sakalo, Victorya A., additional, Kostyukov, Kirill V., additional, Bahtiyar, Mert O., additional, Wilpers, Abigail, additional, Kilby, Mark D., additional, Tiblad, Eleonor, additional, Oepkes, Dick, additional, Middeldorp, Johanna M., additional, Haak, Monique C., additional, Klumper, Frans J.C.M., additional, Akkermans, Joost, additional, and Slaghekke, Femke, additional

Published
2020
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22. Blockade of the kallikrein-kinin system reduces endothelial complement activation in vascular inflammation

Author

Davalieva, Katarina, Makridakis, Manousos, Vlahou, Antonia, Frantzi, Maria, Boizard, Franck, Moussaoui, Nabila, Lescat, Ophélie, Fedou, Camille, Feuillet, Guylène, Casemayou, Audrey, Neau, Eric, Decatte, Luc, Raaijmakers, Anke, Vayssière, Christophe, Goua, Valérie, Lucas, Charlotte, Benachi, Alexandra, Delmas, Hélène Laurichesse, Allain-Launay, Emma, Boudailliez, Bernard, Simon, Elisabeth, Noel, Catherine, Floch, Corinne, Bourdat-Michel, Guylène, Weingertner, Anne-Sophie, Oury, Jean-François, Baudouin, Véronique, Bory, Jean-Paul, Pietrement, Christine, Fiorenza, Maryse, Kessler, Sylvie, Auriol, Françoise Conte, Marcorelles, Pascale, Collardeau-Frachon, Sophie, Magalhães, Pedro, Batut, Julie, Blader, Patrick, Saulnier Blache, Jean-Sebastien, Allegaert, Karel, Aubard, Yves, Basmaison, Odile, Benevent, Jean-Baptiste, Biquard, Florence, Champion, Gérard, Delbosc, Jean-Marie, Eckart, Philippe, Gaucherand, Pascal, Guigonis, Vincent, Hougas, Blandine, Martin, Alain, Martin, Sophie, Maupin-Hyvonnet, Mariannick, Merveille, Marina, Mousty, Eve, Nobili, François, Taque, Sophie, Latosinska, Agnieszka, Faguer, Stanislas, Beige, Joachim, van der Zanden, Loes, Levtchenko, Elena, Moulos, Panogiotis, Lounis, Nadia, Conte-Auriol, Françoise, Olsen, Henning, Hindryckx, An, De Catte, Luc, Vayssieres, Christophe, Sartor, Agnes, Groussolles, Marion, Plard, Christelle, Guerby, Paul, Connan, Laure, Morin, Mathieu, Simon, Elizabeth, Breaud, Jean, Saliou, Anne-Hélène, De Parscau, Loic, Jay, Nadine, Germouty, Isabelle, Le Bouar, Gwenaelle, Ryckewaert, Amelie, Manca-Pellissier, Marie-Christine, Merrot, Thierry, Laurichesse, Helene, Gallot, Denis, Bessenay, Lucie, Bidat, Laurent, Boize, Philippe, Winer, Norbert, Allain-Launey, Emma, Le Vaillant, Claudine, Prieur, Fabienne, Lavocat, Marie-Pierre, Coatleven, Frederic, Debromez, Eric, Harembat, Jérôme, Llanas, Brigitte, Favre, Romain, Moog, Raphael, Zaloszyc, Ariane, Massardier, Jérôme, DEMEDE, Delphine, Perrotin, Franck, Cloarec, Sylvie, Vequeau-Goua, Valérie, Descombes, Emmanuelle, Boulot, Pierre, Morin, Denis, Fuchs, Florent, Tenenbaum, Julie, Ville, Yves, Blanc, Thomas, Heidet, Laurence, Paris, Anne, Dobremez, Eric, Froute, Marie-Françoise, Gondry, Jean, Muszynski, Charles, Haraux, Elodie, Lobelle, Fabienne, Chevreau, Julien, Rosenblatt, Jonathan, Baudoin, Véronique, Deschenes, Georges, Guigue, Virginie, Amblard, Florence, Bourdat-Michel, Guylhène, Wühl, Elke, Schaefer, Franz, Elsässer, Michael, Persico, Nicola, Rossi, Federica, Manzoni, Gianantonio, De Marco, Erika, Montini, Giovanni, Capone, Valentina, Caforio, Leonardo, Zaccara, Antonio, Innocenzi, Michele, Bagolan, Pietro, Capozza, Nicola, Castagnetti, Marco, Mancini, Mariangela, Oepkes, Dick, van Scheltema, Phebe Adama, Feitz, Wout, Kortmann, Barbara, Schreuder, Michiel, Pawłowska, Barbara, Fortecka-Piestrzeniewicz, Katarzyna, Olejniczak, Dariusz, Ariceta, Gema, Arevalo, Silvia, RODO, Carlota, Fossum, Magdalena, Lindgren, Peter, Parvex, Paloma, Chehade, Hassib, He, Tianlin, Metzger, Jochen, Mullen, William, Mischak, Harald, Zürbig, Petra, Jankowski, Vera, Buffin-Meyer, Bénédicte, Tkaczyk, Marcin, Stańczyk, Małgorzata, Breuil, Benjamin, Siwy, Justyna, Szaflik, Krzysztof, Talar, Tomasz, Wojtera, Justyna, Krzeszowski, Waldemar, Decramer, Stéphane, Lopatko Fagerström, Ingrid, Ståhl, Anne-lie, Mossberg, Maria, Tati, Ramesh, Kristoffersson, Ann-Charlotte, Kahn, Robin, Bascands, Jean-Loup, Klein, Julie, Schanstra, Joost, Segelmark, Mårten, Karpman, Diana, Department of Pediatrics [Lund, Sweden] (Clinical Sciences), Lund University [Lund], Wallenberg Center for Molecular Medicine [Lund, Sweden], Diabète athérothrombose et thérapies Réunion Océan Indien (DéTROI), Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Nephrology [Lund, Sweden] (Clinical Sciences Lund), Department of Medical and Health Sciences [Lund, Sweden], Linköping University (LIU), The study was supported by The Swedish Research Council (K2015-99X-22877-01-6 and 2017-01920), The Knut and Alice Wallenberg Foundation (Wallenberg Clinical Scholar 2015.0320), The Torsten Söderberg Foundation, Skåne Centre of Excellence in Health, IngaBritt och Arne Lundberg's Research Foundation, Crown Princess Lovisa's Society for Child Care, Region Skåne and The Konung Gustaf V:s 80-årsfond (all to DK). Alfred Österlund Foundation (to LMFLL and RK). TheWallenberg Center forMolecular Medicine, The Swedish RheumatismAssociation, The Anna-Greta Crafoord Foundation, Greta and Johan Kock's Foundation, the Samariten Foundation, Fanny Ekdahl foundation, the Jerring foundation and the Thelma Zoegas Foundation (to RK). JPS and JK were partially funded by a grant from the 'Fondation pour la Recherche Médicale' (grant number DEQ20170336759). MS was funded by The Swedish Rheumatism Association and the Ingrid Asp Foundation., Schanstra, Joost, Macedonian Academy of Sciences and Arts [Skopje, North Macedonia] (MASA), Biomedical Research Foundation of the Academy of Athens (BRFAA), Mosaiques Diagnostics & Therapeutics (MOSAIQUES DIAGNOSTICS & THERAPEUTICS), Mosaiques Diagnostics & Therapeutics AG, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Institut de médecine moléculaire de Rangueil (I2MR), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IFR150-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Toulouse [Toulouse], KfH-Nierenzentrum und Klinikum St. Georg, Nephrologie, Leipzig, Radboud University Medical Center [Nijmegen], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), HybridStat Predictive Analytics [Athens, Greece], Centre d'investigation clinique de Toulouse (CIC 1436), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), University Hospitals Leuven [Leuven], Heidelberg University Hospital [Heidelberg], University of Milan, Mosaiques Diagnostics GmbH [Hanovre, Allemagne], Institute of Cardiovascular and Medical Sciences [Glasgow], University of Glasgow, Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany] (UKA), RWTH Aachen University, Polish Mother’s Memorial Hospital Research Institute [Lodz] (ICZMP), Mosaiques Diagnostics GmbH [Hannover, Germany], Mosaiques Diagnostics and Therapeutics AG [Hannover, Germany], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de La Réunion (UR), and Université Fédérale Toulouse Midi-Pyrénées

Subjects
0301 basic medicine, Male, Research paper, Mouse, Kallikrein-Kinin System, [SDV]Life Sciences [q-bio], Pharmacology, Kidney, Mice, 0302 clinical medicine, Glomerular C3 deposition, Cell-Derived Microparticles, Complement Activation, Cells, Cultured, Chemistry, General Medicine, Kinin, Middle Aged, Receptor antagonist, 3. Good health, [SDV] Life Sciences [q-bio], medicine.anatomical_structure, 030220 oncology & carcinogenesis, Female, medicine.symptom, Endothelial microvesicles, Complement C1 Inhibitor Protein, Protein Binding, Vasculitis, Complement, Radiology, Nuclear Medicine and Medical Imaging, Adult, Endothelium, medicine.drug_class, Inflammation, Bradykinin, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Classical complement pathway, medicine, Animals, Humans, Aged, Endothelial Cells, Biological Transport, Complement System Proteins, Microvesicles, Complement system, Disease Models, Animal, 030104 developmental biology, Immunoglobulin G, Endothelium, Vascular, Radiologi och bildbehandling
Abstract

Background: The complement and kallikrein-kinin systems (KKS) are activated during vascular inflammation. The aim of this study was to investigate if blockade of the KKS can affect complement activation on the endothelium during inflammation. Methods: Complement deposition on endothelial microvesicles was assayed in vasculitis patient plasma samples and controls. Plasma was perfused over glomerular endothelial cells and complement deposition assayed by flow cytometry. The effect of the kinin system was assessed using kinin receptor antagonists and C1-inhibitor. The in vivo effect was assessed in kidney sections from mice with nephrotoxic serum-induced glomerulonephritis treated with a kinin receptor antagonist. Findings: Vasculitis patient plasma had significantly more C3- and C9-positive endothelial microvesicles than controls. Perfusion of patient acute-phase plasma samples over glomerular endothelial cells induced the release of significantly more complement-positive microvesicles, in comparison to remission or control plasma. Complement activation on endothelial microvesicles was reduced by kinin B1- and B2-receptor antagonists or by C1-inhibitor (the main inhibitor of the classical pathway and the KKS). Likewise, perfusion of glomerular endothelial cells with C1-inhibitor-depleted plasma induced the release of complement-positive microvesicles, which was significantly reduced by kinin-receptor antagonists or C1-inhibitor. Mice with nephrotoxic serum-induced glomerulonephritis exhibited significantly reduced glomerular C3 deposition when treated with a B1-receptor antagonist. Interpretation: Excessive complement deposition on the endothelium will promote endothelial injury and the release of endothelial microvesicles. This study demonstrates that blockade of the KKS can reduce complement activation and thereby the inflammatory response on the endothelium. (C) 2019 The Authors. Published by Elsevier B.V. Funding Agencies|Swedish Research CouncilSwedish Research Council [K2015-99X-22877-01-6, 2017-01920]; Knut and Alice Wallenberg FoundationKnut & Alice Wallenberg Foundation [2015.0320]; Torsten Soderberg Foundation; Skane Centre of Excellence in Health; Crown Princess Lovisas Society for Child Care; Konung Gustaf V:s 80-arsfond; Alfred Osterlund Foundation; Wallenberg Center for Molecular Medicine; Swedish Rheumatism Association; Anna-Greta Crafoord Foundation; Greta and Johan Kocks Foundation; Samariten Foundation; Fanny Ekdahl foundation; Jerring foundation; Fondation pour la Recherche MedicaleFondation pour la Recherche Medicale [DEQ20170336759]; Ingrid Asp Foundation; IngaBritt och Arne Lundbergs Research Foundation; Region Skane; Thelma Zoegas Foundation

Published
2019
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23. Fetoscopic Release of Amniotic Band Syndrome: An Update.

Author

Minella, Chris, Costantino, Benedicte, Ruano, Rodrigo, Koch, Antoine, Weingertner, Anne‐Sophie, Favre, Romain, and Sananes, Nicolas

Subjects
SYNDROMES, AMPUTATION
Abstract

Amniotic band syndrome is a rare condition. There have been few cases reported of fetoscopic band dissection. The aim of this case series is to report 3 cases of fetoscopic treatment for amniotic band syndrome, including indication for surgery, technical aspects, complications and outcomes. Fetoscopic treatment was performed respectively at 23 5/7, 26 5/7 and 18 3/7 weeks' gestation. Two procedures were performed with a laser fiber through a single trocar whereas one surgery was performed with scissors. In conclusion, fetoscopic release of the amniotic bands in case of amniotic band syndrome is feasible with encouraging results in order to prevent amputation and dysfunction of the extremities. [ABSTRACT FROM AUTHOR]

Published
2021
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24. Evaluation of long-term neurodevelopment in twin-twin transfusion syndrome after laser therapy

Author

Sananès, Nicolas, Gabriele, Victor, Weingertner, Anne Sophie, Ruano, Rodrigo, Sanz-Cortes, Magdalena, Gaudineau, Adrien, Langer, Bruno, Nisand, Israël, Akladios, Cherif, Favre, Romain, Biomatériaux et Bioingénierie (BB), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Immuno-Rhumatologie Moléculaire, and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Strasbourg (UNISTRA)

Subjects
[SDV.BIO]Life Sciences [q-bio]/Biotechnology
Abstract

Objective: The primary objective of our study was to evaluate the long-term neurodevelopment outcome after laser surgery for twin-twin transfusion syndrome (TTTS). The secondary objective was to identify perinatal prognostic factors associated with neurodevelopmental impairment. Method: This was a single-center cohort prospective study carried out in pregnancies complicated by TTTS and treated by laser. Neurodevleopmental assesment included the administration of Ages and Stages Questionnaires® (ASQ), for the infants between 2 and 5 years of age. Results: A total of 187 patients underwent a laser for TTTS between 2004 and 2013. Significant brain lesions were detected in eight (2.9%) cases by ultrasound and/or magnetic resonance imaging including intraventricular hemorrhage, periventricular leukomalacia, and porencephaly. Questionnaires were administered to 126 children (50.4%) at 24 months or older at the moment of testing. There were 13.5% of those infants who had an abnormal ASQ (established as one area or more scoring < 2 SD) at 3.6 years ±1.3 follow-up. There was a higher rate of abnormal ASQ among the infants with a birth weight below the fifth percentile (p = 0.036). Conclusion: Twin-twin transfusion syndrome is associated with a risk of abnormal neurological development, even in case of laser surgery. Further studies are necessary to identify the risk factors for neurological impairment.

Published
2016
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27. Mutations in theERCC2(XPD) gene associated with severe fetal ichthyosis and dysmorphic features

Author

Miguet, Marguerite, primary, Thevenon, Julien, additional, Laugel, Vincent, additional, Lefebvre, Mathilde, additional, Bourchany, Aurélie, additional, Rivière, Jean-Baptiste, additional, Duffourd, Yannis, additional, Schaefer, Elise, additional, Antal, Maria Cristina, additional, Abida, Rosalie, additional, Weingertner, Anne-Sophie, additional, Kremer, Valérie, additional, Vabres, Pierre, additional, Morice-Picard, Fanny, additional, Gonzales, Marie, additional, Lipsker, Dan, additional, Fraitag, Sylvie, additional, Mandel, Jean-Louis, additional, Chelly, Jamel, additional, Dollfus, Hélène, additional, Faivre, Laurence, additional, Thauvin-Robinet, Christel, additional, Calmels, Nadège, additional, and El Chehadeh, Salima, additional

Published
2016
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29. Experimental fetal endoscopic tracheal occlusion in rhesus and cynomolgus monkeys: nonhuman primate models

Author

Sananès, Nicolas, primary, Ruano, Rodrigo, additional, Weingertner, Anne-Sophie, additional, Regnard, Pierrick, additional, Salmon, Yves, additional, Kohler, Anne, additional, Miry, Claire, additional, Mager, Cécile, additional, Guerra, Fernando, additional, Schneider, Anne, additional, Becmeur, François, additional, Leroy, Joël, additional, Dimarcq, Jean-Luc, additional, Debry, Christian, additional, and Favre, Romain, additional

Published
2014
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30. Fetoscopic Laser Coagulation of the Vascular Equator Versus Selective Coagulation for Twin-to-Twin Transfusion Syndrome

Author

Slaghekke, Femke, primary, Lopriore, Enrico, additional, Lewi, Liesbeth, additional, Middeldorp, Johanna M., additional, van Zwet, Erik W., additional, Weingertner, Anne-Sophie, additional, Klumper, Frans J., additional, DeKoninck, Philip, additional, Devlieger, Roland, additional, Kilby, Mark D., additional, Rustico, Maria Angela, additional, Deprest, Jan, additional, Favre, Romain, additional, and Oepkes, Dick, additional

Published
2014
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31. 173: Residual anastomoses after fetoscopic laser coagulation of the vascular equator versus selective coagulation for twin-to-twin transfusion syndrome

Author

Slaghekke, Femke, primary, Lewi, Liesbeth, additional, Middeldorp, Johanna, additional, Weingertner, Anne-Sophie, additional, Klumper, Frans, additional, DeKoninck, Philip, additional, Devlieger, Roland, additional, Kilby, Mark, additional, Rustico, MariaAngela, additional, Deprest, Jan, additional, Favre, Romain, additional, Oepkes, Dick, additional, and Lopriore, Enrico, additional

Published
2014
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32. Mutations in the ERCC2 (XPD) gene associated with severe fetal ichthyosis and dysmorphic features.

Author

Miguet, Marguerite, Thevenon, Julien, Laugel, Vincent, Lefebvre, Mathilde, Bourchany, Aurélie, Rivière, Jean‐Baptiste, Duffourd, Yannis, Schaefer, Elise, Antal, Maria Cristina, Abida, Rosalie, Weingertner, Anne‐Sophie, Kremer, Valérie, Vabres, Pierre, Morice‐Picard, Fanny, Gonzales, Marie, Lipsker, Dan, Fraitag, Sylvie, Mandel, Jean‐Louis, Chelly, Jamel, and Dollfus, Hélène

Abstract

What's Already Known About This Topic? Congenital ichthyosis is a condition that includes several distinct subtypes with significant genetic heterogeneity.Defects in the ERCC2 [xeroderma pigmentosum (XP) complementation group D] gene lead to one of several clinical diseases, including XP, trichothiodystrophy, cerebrooculofacioskeletal syndrome, XP/Cockayne syndrome, and XP/trichothiodystrophy.What Does This Study Add? This observation enlarges the phenotypic spectrum of ERCC2 (XP complementation group D) mutations to severe fetal cases and expands the molecular basis of congenital ichthyosis by reporting the prenatal expression of a very rare nucleotide excision repair‐related condition. [ABSTRACT FROM AUTHOR]

Published
2016
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35. Experimental fetal endoscopic tracheal occlusion in rhesus and cynomolgus monkeys: nonhuman primate models.

Author

Sananès, Nicolas, Ruano, Rodrigo, Weingertner, Anne-Sophie, Regnard, Pierrick, Salmon, Yves, Kohler, Anne, Miry, Claire, Mager, Cécile, Guerra, Fernando, Schneider, Anne, Becmeur, François, Leroy, Joël, Dimarcq, Jean-Luc, Debry, Christian, and Favre, Romain

Subjects
ENDOSCOPIC surgery, FETAL surgery, ARTERIAL occlusions, THIRD trimester of pregnancy, LABORATORY monkeys
Abstract

Objective: The monkey model is the best model to investigate some physiological response to the fetal transitory tracheal occlusion but it has never been described inMacacamonkeys. The aim of this study was to evaluate the feasibility of fetal endoscopic tracheal occlusion (FETO) in a non-human primate model. Methods: Pregnant rhesus monkeys and cynomolgus were tested as a potential experimental model for FETO in the third trimester of pregnancy, by performing fetal tracheoscopies with and without tracheal occlusion. Results: A total of 22 pregnancies were followed in 16 monkeys and underwent fetal surgery. Percutaneous endoscopic access to the uterine cavity was possible in 20 cases (91%). Of these 20 pregnant monkeys, fetal tracheoscopy could be achieved in 15 cases (75%). In rhesus monkeys, the time between the onset of endoscopy and tracheal penetration decreases as operator experience increases. Neither maternal morbidity nor mortality was related to surgery. Two fetal losses were possibly due to the procedure. Conclusion: FETO is feasible in the non-human primate, which closely reflects procedures in humans. The non-human primate model for FETO, specially the rhesus monkeys, may be useful for future studies concerning the mechanisms related to the lung growth after transitory fetal tracheal occlusion. [ABSTRACT FROM AUTHOR]

Published
2015
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36. Role of Intraoperative Neuromonitoring of the Recurrent Laryngeal Nerve in High-Risk Thyroid Surgery.

Author

Atallah, Ihab, Dupret, Agnès, Carpentier, Anne-Sophie, Weingertner, Anne Sophie, Volkmar, Pierre-Philippe, and Rodier, Jean-François

Subjects
THYROID gland surgery, LARYNX injuries, LARYNGEAL nerves, SURGICAL complications, OTOLARYNGOLOGY, SURGERY
Abstract

Copyright of Journal of Otolaryngology -- Head & Neck Surgery is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2009
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37. [Embryo reduction in twin pregnancy on maternal request: A French practice study].

Author

Pasteau C, Bettahar K, Weingertner AS, Bouhanna P, and Sananès N

Abstract

Introduction: In France, embryo reduction is controversial in twin pregnancy, especially when there is no underlying pathology. The objective of this study was to establish the status of this practice in France and to depict the ethical issues around this problematic., Study Design: A questionnaire drafted by Maternal and Fetal Medicine physicians and family planning teams of the University Hospital from Strasbourg was distributed to the 48 French Multidisciplinary Prenatal Diagnosis Centers, among which 28 answered (58,3%)., Results: Embryo reduction in twin pregnancy on maternal request has already challenged 71% of the centers; 29% have performed such a reduction. The overall position of the centers to these requests is negative (3.1/10), with very mixed levels of in-team agreement. The main arguments against this practice are that twin pregnancy is not a pathology, that embryo reduction exposes to the risk of loosing the entire pregnancy, the feeling of being held hostage with the alternative of abortion of the whole pregnancy, and the lack of legal framing. On the contrary, the arguments in favor of the reduction are: that the reduction can avoid an abortion, that this type of reduction can be related to a partial abortion, that it responds to women's rights and that mental health is an integral part of women's health., Conclusion: There is no consensus about how to respond to patients requesting for embryo reduction in twin pregnancy. However, the majority of Centers have been confronted with it and it would be necessary to open the debate on this problem and the ethical questions it raises., (Copyright © 2024 Elsevier Masson SAS. All rights reserved.)

Published
2024
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38. Evaluation of long-term neurodevelopment in twin-twin transfusion syndrome after laser therapy.

Author

Sananès N, Gabriele V, Weingertner AS, Ruano R, Sanz-Cortes M, Gaudineau A, Langer B, Nisand I, Akladios CY, and Favre R

Subjects
Adult, Cerebral Hemorrhage epidemiology, Cerebral Ventricles diagnostic imaging, Child, Preschool, Cohort Studies, Echoencephalography, Female, Humans, Leukomalacia, Periventricular epidemiology, Magnetic Resonance Imaging, Neurodevelopmental Disorders epidemiology, Porencephaly epidemiology, Pregnancy, Prospective Studies, Surveys and Questionnaires, Twins, Monozygotic, Young Adult, Brain diagnostic imaging, Cerebral Hemorrhage diagnostic imaging, Fetal Therapies methods, Fetofetal Transfusion surgery, Laser Therapy methods, Leukomalacia, Periventricular diagnostic imaging, Neurodevelopmental Disorders physiopathology, Porencephaly diagnostic imaging
Abstract

Objective: The primary objective of our study was to evaluate the long-term neurodevelopment outcome after laser surgery for twin-twin transfusion syndrome (TTTS). The secondary objective was to identify perinatal prognostic factors associated with neurodevelopmental impairment., Method: This was a single-center cohort prospective study carried out in pregnancies complicated by TTTS and treated by laser. Neurodevleopmental assesment included the administration of Ages and Stages Questionnaires® (ASQ), for the infants between 2 and 5 years of age., Results: A total of 187 patients underwent a laser for TTTS between 2004 and 2013. Significant brain lesions were detected in eight (2.9%) cases by ultrasound and/or magnetic resonance imaging including intraventricular hemorrhage, periventricular leukomalacia, and porencephaly. Questionnaires were administered to 126 children (50.4%) at 24 months or older at the moment of testing. There were 13.5% of those infants who had an abnormal ASQ (established as one area or more scoring < 2 SD) at 3.6 years ±1.3 follow-up. There was a higher rate of abnormal ASQ among the infants with a birth weight below the fifth percentile (p = 0.036)., Conclusion: Twin-twin transfusion syndrome is associated with a risk of abnormal neurological development, even in case of laser surgery. Further studies are necessary to identify the risk factors for neurological impairment. © 2016 John Wiley & Sons, Ltd., (© 2016 John Wiley & Sons, Ltd.)

Published
2016
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