249 results on '"Weingart, Jon D."'
Search Results
2. Craniotomy versus craniectomy for traumatic acute subdural hematoma—coarsened exact matched analysis of outcomes
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Ran, Kathleen R., Vattipally, Vikas N., Giwa, Ganiat A., Myneni, Saket, Raj, Divyaansh, Dardick, Joseph M., Rincon-Torroella, Jordina, Ye, Xiaobu, Byrne, James P., Suarez, Jose I., Lin, Shih-Chun, Jackson, Christopher M., Mukherjee, Debraj, Gallia, Gary L., Huang, Judy, Weingart, Jon D., Azad, Tej D., and Bettegowda, Chetan
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- 2024
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3. 124 Craniotomy Versus Craniectomy for Traumatic Acute Subdural Hematoma Coarsened Exact Matched Analysis of Outcomes
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Azad, Tej D., primary, Ran, Kathleen Renee, additional, Vattipally, Vikas, additional, Giwa, Ganiat, additional, Myneni, Saket, additional, Raj, Divyaansh, additional, Dardick, Joseph, additional, Rincon Torroella, Jordina N., additional, Ye, Xiaobu, additional, Byrne, James, additional, Suarez, Jose, additional, Lin, Shih-Chun, additional, Jackson, Christopher Mitchell, additional, Mukherjee, Debraj Raj, additional, Gallia, Gary L., additional, Huang, Judy, additional, Weingart, Jon D., additional, and Bettegowda, Chetan, additional
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- 2024
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4. Impact of COVID-19 on an Academic Neurosurgery Department: The Johns Hopkins Experience
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Khalafallah, Adham M., Jimenez, Adrian E., Lee, Ryan P., Weingart, Jon D., Theodore, Nicholas, Cohen, Alan R., Tamargo, Rafael J., Huang, Judy, Brem, Henry, and Mukherjee, Debraj
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- 2020
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5. Impact of antithrombotic medications and reversal strategies on the surgical management and outcomes of traumatic acute subdural hematoma
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Vattipally, Vikas N., primary, Ran, Kathleen R., additional, Giwa, Ganiat A., additional, Myneni, Saket, additional, Dardick, Joseph M., additional, Rincon-Torroella, Jordina, additional, Ye, Xiaobu, additional, Byrne, James P., additional, Suarez, Jose I., additional, Lin, Shih-Chun, additional, Jackson, Christopher M., additional, Mukherjee, Debraj, additional, Gallia, Gary L., additional, Huang, Judy, additional, Weingart, Jon D., additional, Azad, Tej D., additional, and Bettegowda, Chetan, additional
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- 2023
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6. Risk of Subdural Hematoma Expansion in Patients With End-Stage Renal Disease: Continuous Venovenous Hemodialysis Versus Intermittent Hemodialysis.
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Ran, Kathleen R., Ejimogu, Nna-Emeka, Yang, Wuyang, Kilgore, Collin B., Nair, Sumil K., Monroy Trujillo, Jose M., Jackson, Christopher M., Mukherjee, Debraj, Anderson, William S., Gallia, Gary L., Weingart, Jon D., Robinson, Shenandoah, Cohen, Alan R., Bettegowda, Chetan, Huang, Judy, Tamargo, Rafael J., and Xu, Risheng
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- 2024
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7. Podocalyxin-like protein is expressed in glioblastoma multiforme stem-like cells and is associated with poor outcome.
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Binder, Zev A, Siu, I-Mei, Eberhart, Charles G, Ap Rhys, Colette, Bai, Ren-Yuan, Staedtke, Verena, Zhang, Hao, Smoll, Nicolas R, Piantadosi, Steven, Piccirillo, Sara G, Dimeco, Francesco, Weingart, Jon D, Vescovi, Angelo, Olivi, Alessandro, Riggins, Gregory J, and Gallia, Gary L
- Subjects
Cell Line ,Tumor ,Spheroids ,Cellular ,Humans ,Glioblastoma ,Brain Neoplasms ,Sialoglycoproteins ,RNA-Binding Proteins ,Nerve Tissue Proteins ,Prognosis ,Flow Cytometry ,Survival Analysis ,Cell Differentiation ,Cell Proliferation ,Gene Expression Regulation ,Neoplastic ,Adult ,Neoplastic Stem Cells ,SOXB1 Transcription Factors ,Gene Knockdown Techniques ,Neoplasm Grading ,Polycomb Repressive Complex 1 ,Biomarkers ,Tumor ,General Science & Technology - Abstract
Glioblastoma multiforme (GBM) is the most common primary malignant adult brain tumor and is associated with poor survival. Recently, stem-like cell populations have been identified in numerous malignancies including GBM. To identify genes whose expression is changed with differentiation, we compared transcript profiles from a GBM oncosphere line before and after differentiation. Bioinformatic analysis of the gene expression profiles identified podocalyxin-like protein (PODXL), a protein highly expressed in human embryonic stem cells, as a potential marker of undifferentiated GBM stem-like cells. The loss of PODXL expression upon differentiation of GBM stem-like cell lines was confirmed by quantitative real-time PCR and flow cytometry. Analytical flow cytometry of numerous GBM oncosphere lines demonstrated PODXL expression in all lines examined. Knockdown studies and flow cytometric cell sorting experiments demonstrated that PODXL is involved in GBM stem-like cell proliferation and oncosphere formation. Compared to PODXL-negative cells, PODXL-positive cells had increased expression of the progenitor/stem cell markers Musashi1, SOX2, and BMI1. Finally, PODXL expression directly correlated with increasing glioma grade and was a marker for poor outcome in patients with GBM. In summary, we have demonstrated that PODXL is expressed in GBM stem-like cells and is involved in cell proliferation and oncosphere formation. Moreover, high PODXL expression correlates with increasing glioma grade and decreased overall survival in patients with GBM.
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- 2013
8. Amide proton transfer-weighted magnetic resonance image-guided stereotactic biopsy in patients with newly diagnosed gliomas
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Jiang, Shanshan, Eberhart, Charles G., Zhang, Yi, Heo, Hye-Young, Wen, Zhibo, Blair, Lindsay, Qin, Huamin, Lim, Michael, Quinones-Hinojosa, Alfredo, Weingart, Jon D., Barker, Peter B., Pomper, Martin G., Laterra, John, van Zijl, Peter C.M., Blakeley, Jaishri O., and Zhou, Jinyuan
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- 2017
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9. Risk Factors for Preoperative Seizures and Loss of Seizure Control in Patients Undergoing Surgery for Metastatic Brain Tumors
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Wu, Adela, Weingart, Jon D., Gallia, Gary L., Lim, Michael, Brem, Henry, Bettegowda, Chetan, and Chaichana, Kaisorn L.
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- 2017
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10. Progressive Low-Grade Glioma: Assessment of Prognostic Importance of Histologic Reassessment and MRI Findings
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Narang, Amol K., Chaichana, Kaisorn L., Weingart, Jon D., Redmond, Kristin J., Lim, Michael, Olivi, Alessandro, Quinones-Hinojosa, Alfred, and Kleinberg, Lawrence R.
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- 2017
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11. Table S1, Figs. S1-3 from Identifying Recurrent Malignant Glioma after Treatment Using Amide Proton Transfer-Weighted MR Imaging: A Validation Study with Image-Guided Stereotactic Biopsy
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Jiang, Shanshan, primary, Eberhart, Charles G., primary, Lim, Michael, primary, Heo, Hye-Young, primary, Zhang, Yi, primary, Blair, Lindsay, primary, Wen, Zhibo, primary, Holdhoff, Matthias, primary, Lin, Doris, primary, Huang, Peng, primary, Qin, Huamin, primary, Quinones-Hinojosa, Alfredo, primary, Weingart, Jon D., primary, Barker, Peter B., primary, Pomper, Martin G., primary, Laterra, John, primary, van Zijl, Peter C.M., primary, Blakeley, Jaishri O., primary, and Zhou, Jinyuan, primary
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- 2023
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12. Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord
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Wang, Yuxuan, Springer, Simeon, Zhang, Ming, McMahon, K. Wyatt, Kinde, Isaac, Dobbyn, Lisa, Ptak, Janine, Brem, Henry, Chaichana, Kaisorn, Gallia, Gary L., Gokaslan, Ziya L., Groves, Mari L., Jallo, George I., Lim, Michael, Olivi, Alessandro, Quinones-Hinojosa, Alfredo, Rigamonti, Daniele, Riggins, Greg J., Sciubba, Daniel M., Weingart, Jon D., Wolinsky, Jean-Paul, Ye, Xiaobu, Oba-Shinjo, Sueli Mieko, Marie, Suely K. N., Holdhoff, Matthias, Agrawal, Nishant, Diaz, Luis A., Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, and Bettegowda, Chetan
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- 2015
13. High-Grade Astrocytoma/Glioblastoma
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Weingart, Jon D., McGirt, Matthew J., Brem, Henry, Tonn, Jörg-Christian, editor, Westphal, Manfred, editor, and Rutka, James T., editor
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- 2010
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14. High-Grade Astrocytoma/Glioblastoma
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Weingart, Jon D., McGirt, Matthew J., Brem, Henry, Tonn, Jörg-Christian, editor, Grossman, Stuart A., editor, Rutka, James T., editor, and Westphal, Manfred, editor
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- 2006
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15. Gliadel® : A New Method for the Treatment of Malignant Brain Tumors
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DiMeco, Francesco, Brem, Henry, Weingart, Jon D., Olivi, Alessandro, Teicher, Beverly A., editor, and Brown, Dennis M., editor
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- 2004
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16. Seizure Control for Patients Undergoing Meningioma Surgery
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Chaichana, Kaisorn L., Pendleton, Courtney, Zaidi, Hasan, Olivi, Alessandro, Weingart, Jon D., Gallia, Gary L., Lim, Michael, Brem, Henry, and Quiñones-Hinojosa, Alfredo
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- 2013
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17. Skull Base Leiomyomas and Angioleiomyomas: A Systematic Literature Review and an Uncommon Case Report
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Rincon-Torroella, Jordina, primary, Snyder, M. Harrison, additional, Galaiya, Deepa J., additional, Morris, Meaghan, additional, Weingart, Jon D., additional, and Stewart, C. Matthew, additional
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- 2021
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18. A Crowdsourced Consensus on Supratotal Resection Versus Gross Total Resection for Anatomically Distinct Primary Glioblastoma
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Khalafallah, Adham M, primary, Rakovec, Maureen, additional, Bettegowda, Chetan, additional, Jackson, Christopher M, additional, Gallia, Gary L, additional, Weingart, Jon D, additional, Lim, Michael, additional, Esquenazi, Yoshua, additional, Zacharia, Brad E, additional, Goldschmidt, Ezequiel, additional, Ziu, Mateo, additional, Ivan, Michael E, additional, Venteicher, Andrew S, additional, Nduom, Edjah K, additional, Mamelak, Adam N, additional, Chu, Ray M, additional, Yu, John S, additional, Sheehan, Jason P, additional, Nahed, Brian V, additional, Carter, Bob S, additional, Berger, Mitchel S, additional, Sawaya, Raymond, additional, and Mukherjee, Debraj, additional
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- 2021
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19. Association of preoperative depression and survival after resection of malignant brain astrocytoma
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Gathinji, Muraya, McGirt, Matthew J., Attenello, Frank J., Chaichana, Kaisorn L., Than, Khoi, Olivi, Alessandro, Weingart, Jon D., Brem, Henry, and Quinones-Hinojosa, Alfredo
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- 2009
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20. Histopathological correlates with survival in reoperated glioblastomas
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Woodworth, Graeme F., Garzon-Muvdi, Tomas, Ye, Xiaobu, Blakeley, Jaishri O., Weingart, Jon D., and Burger, Peter C.
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- 2013
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21. Supratentorial Glioblastoma Multiforme: The Role of Surgical Resection Versus Biopsy Among Older Patients
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Chaichana, Kaisorn L., Garzon-Muvdi, Tomas, Parker, Scott, Weingart, Jon D., Olivi, Alessandro, Bennett, Richard, Brem, Henry, and Quiñones-Hinojosa, Alfredo
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- 2011
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22. Incidence of symptomatic retethering after surgical management of pediatric tethered cord syndrome with or without duraplasty
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Samuels, Roger, McGirt, Matthew J., Attenello, Frank J., Garcés Ambrossi, Giannina L., Singh, Neil, Solakoglu, Can, Weingart, Jon D., Carson, Benjamin S., and Jallo, George I.
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- 2009
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23. Symptom recurrence after suboccipital decompression for pediatric Chiari I malformation: analysis of 256 consecutive cases
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McGirt, Matthew J., Attenello, Frank J., Atiba, April, Garces-Ambrossi, Giannina, Datoo, Ghazala, Weingart, Jon D., Carson, Benjamin, and Jallo, George I.
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- 2008
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24. Use of Gliadel (BCNU) Wafer in the Surgical Treatment of Malignant Glioma: A 10-Year Institutional Experience
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Attenello, Frank J., Mukherjee, Debraj, Datoo, Ghazala, McGirt, Matthew J., Bohan, Eileen, Weingart, Jon D., Olivi, Alessandro, Quinones-Hinojosa, Alfredo, and Brem, Henry
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- 2008
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25. The Strata programmable valve for shunt-dependent hydrocephalus: the pediatric experience at a single institution
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Ahn, Edward S., Bookland, Markus, Carson, Benjamin S., Weingart, Jon D., and Jallo, George I.
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- 2007
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26. Systemic BCNU enhances the efficacy of local delivery of a topoisomerase I inhibitor against malignant glioma
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Storm, Phillip B., Renard, Violette M., Moriarity, John L., Tyler, Betty, Wilentz, Robb E., Brem, Henry, and Weingart, Jon D.
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- 2004
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27. Recent Advances in Brain Tumor Therapy: Local Intracerebral Drug Delivery by Polymers
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Guerin, Christopher, Olivi, Alessandro, Weingart, Jon D., Lawson, H. Christopher, and Brem, Henry
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- 2004
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28. Local Delivery of Minocycline and Systemic BCNU have Synergistic Activity in the Treatment of Intracranial Glioma
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Frazier, James L., Wang, Paul P., Case, Daniel, Tyler, Betty M., Pradilla, Gustavo, Weingart, Jon D., and Brem, Henry
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- 2003
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29. Contributors
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Aarabi, Bizhan, primary, Abbott, Rick, additional, Abdulrauf, Saleem I., additional, Acosta, Frank L., additional, Adler, John R., additional, Agazaryan, Nzhde, additional, Aghi, Manish, additional, Ahn, Edward S., additional, Alaraj, Ali, additional, Albert, Gregory W., additional, Albright, Leland, additional, Albuquerque, Felipe C., additional, Alden, Tord D., additional, Alexander, Michael J., additional, Alexandrov, Andrei V., additional, Al-Mefty, Ossama, additional, Alterman, Ron L., additional, Álvarez, Lázaro, additional, Amankulor, Nduka M., additional, Amenta, Peter S., additional, Ames, Christopher P., additional, Amin-Hanjani, Sepideh, additional, Ammirati, Mario, additional, Anderson, Carryn, additional, Anderson, Richard C.E., additional, Anderson, William S., additional, Angevine, Peter D., additional, Arif, Hiba, additional, Arle, Jeffrey E., additional, Armonda, Rocco, additional, Arnold, Paul M., additional, Asadi-Moghaddam, Kaveh, additional, Asghar, Ferhan A., additional, Ashley, William W., additional, Aydin, Sabri, additional, Aygun, Nafi, additional, Baehring, Joachim M., additional, Bagley, Jacob H., additional, Bahgat, Diaa, additional, Bailes, Julian E., additional, Ball, Jonathon R., additional, Baltuch, Gordon H., additional, Bambakidis, Nicholas C., additional, Baraban, Scott C., additional, Barani, Igor J., additional, Barbaro, Nicholas M., additional, Barker, Frederick G., additional, Barnett, Gene H., additional, Barnwell, Stanley L., additional, Barone, Constance M., additional, Barrow, Daniel L., additional, Bartolomei, Fabrice, additional, Bartolomei, Juan, additional, Batchelor, Tracy T., additional, Batjer, H. Hunt, additional, Bauer, Andrew M., additional, Bauman, Joel A., additional, Baumann, Thomas K., additional, Baumgartner, James E., additional, Bayouth, John, additional, Beaumont, Andrew, additional, Bederson, Joshua B., additional, Beisse, Rudolf, additional, Bell, Randy S., additional, Belzberg, Allan, additional, Benabid, Alim Louis, additional, Benarroch, Eduardo E., additional, Benazzouz, Abdelhamid, additional, Bendok, Bernard R., additional, Benzel, Edward C., additional, Berenstein, Alejandro, additional, Berger, Mitchel S., additional, Bergsneider, Marvin, additional, Bertalanffy, Helmut, additional, Bhalla, Tarun, additional, Bidros, Dani S., additional, Biller, José, additional, Bilsky, Mark H., additional, Binder, Devin K., additional, Bingaman, William, additional, Birch, Rolfe, additional, Bishop, Allen T., additional, Black, Peter M., additional, Blount, Jeffrey P., additional, Blumbergs, Peter C., additional, Bohman, Leif-Erik, additional, Boomsaad, Zackary E., additional, Boop, Frederick A., additional, Bou-Haidar, Pascal, additional, Boué, Daniel R., additional, Bourgeois, Blaise F.D., additional, Bowman, Robin M., additional, Bozinov, Oliver, additional, Bramlett, Helen M., additional, Brem, Henry, additional, Brem, Steven, additional, Britz, Gavin W., additional, Brockmeyer, Douglas L., additional, Brooks, David J., additional, Browd, Samuel R., additional, Brown, Paul D., additional, Brown, Robert D., additional, Bruce, Jeffrey N., additional, Brunstrom-Hernandez, Janice E., additional, Buatti, John, additional, Bullock, M. Ross, additional, Burchiel, Kim J., additional, Burger, Peter C., additional, Bussière, Marc R., additional, Bydon, Mohamad, additional, Byrne, Richard W., additional, Calcagnotto, Maria Elisa, additional, Campbell, Victoria A., additional, Campbell, William, additional, Cannon, George M., additional, Caragine, Louis P., additional, Carson, Benjamin S., additional, Cascino, Gregory D., additional, Cascio, Ethan, additional, Castinetti, Frédéric, additional, Cawley, C. Michael, additional, Cetas, Justin S., additional, Chabardès, Stéphan, additional, Chang, Edward F., additional, Chang, Eric C., additional, Chang, Eric L., additional, Chang, Steven D., additional, Chang, Steven W., additional, Chang, Susan M., additional, Chao, Kevin, additional, Chapman, Paul H., additional, Charbel, Fady T., additional, Chauvel, Patrick, additional, Chen, Grace, additional, Cheng, Boyle C., additional, Cheng, Joseph S., additional, Chern, Joshua J., additional, Chiocca, E. Antonio, additional, Choutka, Ondrej, additional, Chowdhry, Shakeel A., additional, Christian, Cindy W., additional, Chuang, Kathy, additional, Claassen, Jan, additional, Clatterbuck, Richard E., additional, Claus, Elizabeth B., additional, Cleary, Daniel R., additional, Coffey, Robert J., additional, Cohen, Alan R., additional, Cole, Andrew J., additional, Connolly, E. Sander, additional, Connolly, Patrick J., additional, Copay, Anne G., additional, Coppens, Jeroen R., additional, Corbett, James J., additional, Corcos, Daniel M., additional, Coric, Domagoj, additional, Cosgrove, Garth Rees, additional, Couldwell, William T., additional, Craig, Stirling, additional, Crawford, Neil R., additional, Crino, Peter B., additional, Crowley, R. Webster, additional, Curt, Bradford A., additional, Czosnyka, Marek, additional, Czosnyka, Zofia, additional, Dadashev, Vladimir Y., additional, Dailey, Andrew T., additional, Danan, Deepa, additional, Danish, Shabbar F., additional, Dashti, Shervin R., additional, David, Carlos A., additional, David, David J., additional, Day, Arthur L., additional, De Salles, Antonio A.F., additional, Dehdashti, Amir R., additional, Del Brutto, Oscar H., additional, Delashaw, Johnny B., additional, Delman, Bradley, additional, DeLong, Mahlon R., additional, DeMonte, Franco, additional, Dhall, Sanjay S., additional, Dias, Mark S., additional, Dickman, Curtis A., additional, Dietrich, W. Dalton, additional, DiLuna, Michael L., additional, Di Meco, Francesco, additional, Dirks, Peter, additional, Dixon, C. Edward, additional, Donoghue, Jacob A., additional, Dorward, Ian G., additional, Doshi, Amish H., additional, Drake, James, additional, Drzymalski, Dan, additional, Du, Rose, additional, Ducruet, Andrew, additional, Duhaime, Ann-Christine, additional, Dumont, Aaron S., additional, Duntsch, Christopher D., additional, Dusick, Joshua R., additional, Dyve, Suzan, additional, Eberwine, James, additional, Eboli, Paula, additional, Ecker, Robert D., additional, Edwards, Richard J., additional, Eichler, Marc E., additional, Engel, Doortje C., additional, Epstein, Nancy E., additional, Ewend, Matthew G., additional, Farhat, Hamad, additional, Farrell, Christopher J., additional, Fehlings, Michael G., additional, Feiz-Erfan, Iman, additional, Feldstein, Neil A., additional, Fessler, Richard G., additional, Figueroa, Juan J., additional, Filler, Aaron G., additional, Findlay, J. Max, additional, Finn, Michael A., additional, Fiorella, David J., additional, Fisher, James L., additional, Fisher, Robert S., additional, Flamm, Eugene S., additional, Fleck, James D., additional, Flemming, Kelly D., additional, Flickinger, John C., additional, Flores-Sarnat, Laura, additional, Follett, Kenneth A., additional, Foote, Kelly D., additional, Fourney, Daryl R., additional, Fraix, Valerie, additional, Frazier, James L., additional, Fried, Itzhak, additional, Friedman, Allan H., additional, Friedman, William A., additional, Friehs, Gerhard M., additional, Fry, Donald E., additional, Fuller, Gregory N., additional, Garcia, Hector H., additional, Gardner, Paul A., additional, Garrett, Mark, additional, Garton, Hugh, additional, Gavin, Cormac G., additional, Gean, Alisa D., additional, Gennarelli, Thomas A., additional, Gerganov, Venelin, additional, Germanwala, Anand V., additional, Gerosa, Massimo, additional, Gerstner, Elizabeth R., additional, Gerszten, Peter C., additional, Ghatan, Saadi, additional, Ghostine, Samer, additional, Giannotta, Steven, additional, Gigante, Paul R., additional, Gilliam, Frank, additional, Gilmer-Hill, Holly, additional, Gjedde, Albert, additional, Glick, Roberta P., additional, Gokaslan, Ziya L., additional, Gologorsky, Yakov, additional, Golshani, Kiarash, additional, Gonzalez, Nestor R., additional, Goodrich, James Tait, additional, Gordon, Tessa, additional, Gorgulho, Alessandra A., additional, Goumnerova, Liliana C., additional, Grady, M. Sean, additional, Grafman, Jordan, additional, Grand, Sylvie, additional, Grant, Gerald A., additional, Graziano, Gregory P., additional, Greenberg, Benjamin, additional, Guest, James, additional, Guha, Abhijit, additional, Günel, Murat, additional, Gupta, Gaurav, additional, Gupta, Nalin, additional, Guridi, Jorge, additional, Guthrie, Barton L., additional, Haddad, Georges F., additional, Haglund, Michael M., additional, Haid, Regis W., additional, Haines, Stephen J., additional, Hamani, Clement, additional, Hamilton, Bronwyn E., additional, Hamilton, D. Kojo, additional, Hankinson, Todd C., additional, Happel, Leo T., additional, Haq, Ihtsham Ul, additional, Haque, Raqeeb, additional, Harbaugh, Robert E., additional, Harraher, Ciara D., additional, Harris, Leo, additional, Harrop, James S., additional, Hassaneen, Wael, additional, Hawkins, Cynthia, additional, Hawryluk, Gregory W.J., additional, Haynes, Neal G., additional, Heary, Robert F., additional, Heimberger, Amy B., additional, Heinricher, Mary M., additional, Hemmen, Thomas M., additional, Henderson, Jaimie M., additional, Heros, Roberto C., additional, Herrup, Karl, additional, Hervey-Jumper, Shawn L., additional, Heuer, Gregory G., additional, Hirsch, Lawrence J., additional, Hirschl, Robert, additional, Hoh, Brian L., additional, Hoh, Daniel J., additional, Holland, Eric C., additional, Holtzheimer, Paul E., additional, Hopkins, L. Nelson, additional, Horner, Philip J., additional, Hovda, David A., additional, Howard, Matthew A., additional, Hsieh, Patrick, additional, Hu, Yin C., additional, Hua, Sherwin E., additional, Huang, Jason H., additional, Huang, Judy, additional, Hughes, Samuel A., additional, Huisman, Thierry A.G.M., additional, Hunt, Matthew A., additional, Hurlbert, R. John, additional, Hurst, Robert W., additional, Huttner, Anita, additional, Hwang, Steven W., additional, Isaias, Ioannis U., additional, Iskandar, Bermans J., additional, Jacob, Arun, additional, Jaeckle, Kurt A., additional, Jagannathan, Jay, additional, Jakacki, Regina I., additional, Jallo, George I., additional, Jane, John A., additional, Janicki, Ryan, additional, Janigro, Damir, additional, Jeelani, N u Owase, additional, Jellinger, Kurt A., additional, Jenkins, Arthur L., additional, Jernigan, Sarah, additional, Jimenez, David F., additional, Johanson, Conrad E., additional, Johnson, J. Patrick, additional, Johnson, Matthew D., additional, Jones, G. Alexander, additional, Jutla, Rajni K., additional, Kainth, Koijan Singh, additional, Kaiser, Michael G., additional, Kakarla, U. Kumar, additional, Kalfas, Iain H., additional, Kalnins, Aleksandrs Uldis, additional, Kano, Hideyuki, additional, Kanpolat, Yucel, additional, Kanter, Adam S., additional, Karimi, Reza J., additional, Kassam, Amin B., additional, Kaufman, Bruce A., additional, Kaufman, Christian B., additional, Kawasaki, Hiroto, additional, Kelley, Brian C., additional, Kellner, Christopher P., additional, Keong, Nicole C., additional, Kestle, John R.W., additional, Khalessi, Alexander A., additional, Khan, Nadia, additional, Khurana, Vini G., additional, Kim, Daniel H., additional, Kim, Dong Gyu, additional, Kim, Dong H., additional, Kim, Jong Hyun, additional, Kim, Louis J., additional, Kim, Paul K., additional, Kim, Thomas Aquinas, additional, Kim, Won, additional, King, James A.J., additional, Kitagawa, Ryan S., additional, Kitchen, Neil D., additional, Klimo, Paul, additional, Kline, David G., additional, Kobayashi, Kazutaka, additional, Kochanek, Patrick M., additional, Kondziolka, Douglas, additional, Kongkham, Paul N., additional, Koski, Tyler R., additional, Kosztowski, Thomas, additional, Krack, Paul, additional, Krauss, Joachim K., additional, Kraut, Michael A., additional, Krayenbühl, Niklaus, additional, Kretschmer, Thomas, additional, Krishnaney, Ajit, additional, Kuntz, Charles, additional, Kuo, Jeffrey V., additional, Kwon, Brian K., additional, Laack, Nadia N. Issa, additional, Lad, Shivanand P., additional, Ladha, Alim M., additional, Ladouceur, Amos K., additional, Lam, Arthur M., additional, Lang, Frederick F., additional, Lanzino, Giuseppe, additional, Lavine, Sean D., additional, Laws, Edward R., additional, Lawton, Michael T., additional, Laxton, Adrian W., additional, Le, Tuong H., additional, LeBas, Jean François, additional, Lebed, Brett D., additional, Lebow, Richard L., additional, Lee, Amy, additional, Lee, Ian, additional, Lee, Seon-Kyu, additional, Lehmann, Emily, additional, Leiphart, James W., additional, Lekovic, Gregory P., additional, Lenz, Frederick A., additional, Leonard, Jeffrey R., additional, LeRoux, Peter D., additional, Lévêque, Marc, additional, Levi, Allan D., additional, Levy, Elad I., additional, Liau, Linda M., additional, Liauw, Jason, additional, Lichtenbaum, Roger, additional, Lichtor, Terry, additional, Limbrick, David D., additional, Lingsma, Hester, additional, Link, Michael J., additional, Linskey, Mark E., additional, Litt, Brian, additional, Litvack, Zachary N., additional, Liu, James K.C., additional, Liu, Kenneth C., additional, Loeffler, Jay S., additional, Loftus, Christopher M., additional, Lonser, Russell R., additional, Louvi, Angeliki, additional, Lozano, Andres M., additional, Lu, Daniel C., additional, Lukas, Rimas V., additional, Lunsford, L. Dade, additional, Luther, Neal, additional, Lylyk, Pedro, additional, Maas, Andrew I.R., additional, Macdonald, R. Loch, additional, Machado, Andre, additional, Macias, Raul, additional, Maciunas, Robert J., additional, Maddux, Brian N., additional, Magistretti, Pierre, additional, Malessy, Martijn J.A., additional, Malhotra, Neil R., additional, Malone, Donald A., additional, Mamelak, Adam N., additional, Mandigo, Christopher E., additional, Mangano, Francesco T., additional, Maniker, Allen H., additional, Manley, Geoffrey T., additional, Marchac, Daniel, additional, Marmarou, Anthony, additional, Maroon, Joseph C., additional, Marshall, Lawrence F., additional, Martin, Neil A., additional, Martin, Timothy J., additional, Mason, Alexander M., additional, Mathews, Marlon S., additional, Mayberg, Helen S., additional, McAllister, James P., additional, McComb, J. Gordon, additional, McCormick, Paul C., additional, McCutcheon, Ian E., additional, McDermott, Michael W., additional, McDougall, Cameron G., additional, McGehee, Matthew, additional, McIntyre, Cameron C., additional, McKhann, Guy M., additional, McKisic, M. Sean, additional, Meaney, David F., additional, Mehta, Minesh P., additional, Mehta, Vivek, additional, Melega, William P., additional, Menezes, Arnold H., additional, Mertens, Patrick, additional, Meyer, Fredric B., additional, Meyer, Scott A., additional, Meyers, Philip M., additional, Michaelides, Costas, additional, Michaud, Karine, additional, Midha, Rajiv, additional, Miele, Vincent J., additional, Miller, Jonathan, additional, Miller, Matthew L., additional, Miller, Neil R., additional, Mitrofanis, John, additional, Miyashiro, Kevin Y., additional, Mocco, J., additional, Modic, Michael T., additional, Moftakhar, Parham, additional, Mohan, Avinash, additional, Monteith, Stephen J., additional, Morcos, Jacques J., additional, Morgan, Michael, additional, Morris, David E., additional, Moss, S. David, additional, Muizelaar, J. Paul, additional, Mukhida, Karim, additional, Mummaneni, Praveen V., additional, Murad, Gregory J.A., additional, Muraszko, Karin, additional, Mussi, Antônio C.M., additional, Najm, Imad, additional, Nakaji, Peter, additional, Narayanan, Sandra, additional, Newell, David W., additional, Nicholas, M. Kelly, additional, Niimi, Yasunari, additional, Nimjee, Shahid M., additional, Niranjan, Ajay, additional, North, Richard B., additional, Novotny, Josef, additional, Nurmikko, Turo, additional, Nutt, Samuel E., additional, Oakes, W. Jerry, additional, Obeso, José A., additional, Ogden, Alfred T., additional, Ogieglo, Lissa, additional, Ogilvy, Christopher S., additional, Okonkwo, David O., additional, Okun, Michael S., additional, Oldfield, Edward H., additional, Olivi, Alessandro, additional, Olvey, Stephen E., additional, Omahen, David, additional, O'Neill, Brent, additional, Oskouian, Rod J., additional, Owen, Robert, additional, Özduman, Koray, additional, Ozturk, Ali Kemal, additional, Pamir, M. Necmettin, additional, Pang, Dachling, additional, Pardini, Jamie, additional, Parent, Andrew D., additional, Park, T.S., additional, Partington, Michael D., additional, Patel, Aman B., additional, Patil, Parag G., additional, Pavese, Nicola, additional, Penn, Richard D., additional, Perin, Noel I., additional, Persing, John A., additional, Petersen, Erika A., additional, Petraglia, Anthony L., additional, Piallat, Brigitte, additional, Piatt, Joseph H., additional, Pickard, John D., additional, Piepmeier, Joseph M., additional, Pilcher, Webster H., additional, Pineda, José, additional, Pinter, Joseph D., additional, Pisculli, Mary L., additional, Pittman, Thomas, additional, Pollack, Ian F., additional, Pollak, Pierre, additional, Pollock, Bruce E., additional, Ponce, Francisco A., additional, Porter, Alyx B., additional, Porter, Randall W., additional, Post, Kalmon D., additional, Powers, Alexander K., additional, Proctor, Mark R., additional, Prost, Robert W., additional, Pugh, Jeffrey, additional, Quiñones-Hinojosa, Alfredo, additional, Raffel, Corey, additional, Rajpal, Sharad, additional, Rangel-Castilla, Leonardo, additional, Rao, Ganesh, additional, Raslan, Ahmed, additional, Rasmussen, Peter A., additional, Ray, Dibyendu K., additional, Raza, Shaan M., additional, Reames, Davis L., additional, Reddy, Chandan G., additional, Redmond, Andy J., additional, Régis, Jean, additional, Reilly, Peter L., additional, Renier, Dominique, additional, Resnick, Daniel K., additional, Reynolds, Renee, additional, Rezai, Ali R., additional, Rhines, Laurence D., additional, Rhoton, Albert L., additional, Ribalta, Teresa, additional, Richardson, R. Mark, additional, Rigamonti, Daniele, additional, Riggins, Gregory J., additional, Riva-Cambrin, Jay, additional, Rizzo, Paolo, additional, Roberts, David W., additional, Robertson, Claudia, additional, Robinson, Lawrence, additional, Robinson, Shenandoah, additional, Roche, Pierre-Hugues, additional, Rockoff, Mark A., additional, Rodts, Gerald E., additional, Romanelli, Pantaleo, additional, Rosenblum, Mark L., additional, Rosenow, Joshua M., additional, Rosner, Michael K., additional, Rovner, Eric S., additional, Runge-Samuelson, Christina L., additional, Russell, Stephen M., additional, Rutka, James T., additional, Sagher, Oren, additional, St. Clair, Eric G., additional, Samii, Madjid, additional, Sampath, Prakash, additional, Samudrala, Srinath, additional, Sanai, Nader, additional, Sanford, Robert A., additional, Santiago, Paul, additional, Santiago-Sim, Teresa, additional, Sarnat, Harvey B., additional, Sawaya, Raymond, additional, Scheld, W. Michael, additional, Shirzadi, Wouter I., additional, Schiff, Nicholas D., additional, Schirmer, Clemens M., additional, Schlesinger, David, additional, Schmidt, Meic H., additional, Schouten, Joost W., additional, Schramm, Johannes, additional, Schuler, Thomas C., additional, Schuster, James M., additional, Schwartz, Theodore H., additional, Schwartzbaum, Judith A., additional, Schweder, Patrick M., additional, Scott, R. Michael, additional, Seigneuret, Eric, additional, Selden, Nathan R., additional, Selman, Warren R., additional, Shaffrey, Christopher I., additional, Shah, Manish N., additional, Shahlaie, Kiarash, additional, Shapiro, William R., additional, Sharma, Deepak, additional, Sheehan, Jason P., additional, Sheehan, Jonas M., additional, Sherma, Arun K., additional, Shiflett, James M., additional, Shih, Helen A., additional, Shils, Jay L., additional, Shin, Alexander Y., additional, Shirzadi, Ali, additional, Siddiqui, Adnan H., additional, Sindou, Marc, additional, Slavin, Konstantin V., additional, Smith, Edward R., additional, Smith, Justin S., additional, Smith, Yoland, additional, Smyth, Matthew D., additional, Sneed, Penny K., additional, Snyder, Brian J., additional, Snyder, Kenneth V., additional, Solomon, Robert A., additional, Sonntag, Volker K.H., additional, Sørensen, Leif, additional, Soriano, Sulpicio G., additional, Souweidane, Mark M., additional, Spears, Julian, additional, Spencer, David, additional, Spencer, Dennis D., additional, Spetzler, Robert F., additional, Spinner, Robert J., additional, Stacey, Brett R., additional, Stacey, William C., additional, Starke, Robert M., additional, Starr, Philip A., additional, Steinberg, Gary K., additional, Stephens, Frederick L., additional, Stern, Barney J., additional, Stevenson, Charles B., additional, Stiner, Eric, additional, Stone, Scellig, additional, Stroud, Nicole L., additional, Stuart, Robert Morgan, additional, Subach, Brian R., additional, Sugrue, Patrick A., additional, Suki, Dima, additional, Sulaiman, Wale A.R., additional, Surdell, Daniel L., additional, Sutherling, William W., additional, Sutton, Leslie N., additional, Syed, Omar N., additional, Tagliati, Michele, additional, Takagi, Yasushi, additional, Tamargo, Rafael J., additional, Tan, Caroline C., additional, Tandon, Nitin, additional, Tatagiba, Marcos, additional, Taylor, Michael D., additional, Telian, Steven A., additional, Teo, Charles, additional, Tessier, Jeffrey M., additional, Than, Khoi D., additional, Thapar, Kamal, additional, Theodore, Nicholas, additional, Thompson, B. Gregory, additional, Tiel,, Robert, additional, Tihan, Tarik, additional, Tilton, Ann, additional, Timmons, Shelly D., additional, Toledo, Maria, additional, Tomita, Tadanori, additional, Tomycz, Nestor D., additional, Torres, Napoleon, additional, Toussaint, Charles P., additional, Trapp, Bruce D., additional, Traynelis, Vincent C., additional, Tubbs, R. Shane, additional, Tumialán, Luis M., additional, Tunkel, Allan R., additional, Umemura, Atsushi, additional, Vaccaro, Alexander R., additional, van Besien, Koen, additional, Vitek, Jerrold L., additional, Vives, Kenneth P., additional, Vogel, Timothy W., additional, Vogelbaum, Michael A., additional, Vollmer, Dennis G., additional, Von Allmen, Gretchen K., additional, von Eckardstein, Kajetan L., additional, Wackym, P. Ashley, additional, Wainwright, Mark, additional, Waldau, Ben, additional, Walker, Marion L., additional, Wallace, M. Christopher, additional, Walsh, Brian, additional, Wang, Huan, additional, Wang, Michael Y., additional, Wang, Vincent Y., additional, Warnick, Ronald E., additional, Webb, Sharon, additional, Weigel, Ralf, additional, Weil, Robert J., additional, Weingart, Jon D., additional, Weir, Bryce, additional, Weiss, Martin, additional, Weiss, Nirit, additional, Welch, William C., additional, Wellons, John C., additional, Wen, Hung Tzu, additional, Wess, Christian, additional, West, G. Alexander, additional, Wetjen, Nicholas M., additional, Whitmore, Robert G., additional, Whitworth, Louis A., additional, Wichmann, Thomas, additional, Wiemels, Joseph L., additional, Wijdicks, Eelco F.M., additional, Wilberger, Adam C., additional, Wilberger, Jack, additional, Wildrick, David M., additional, Wilson, Jason, additional, Winfree, Christopher J., additional, Winn, H. Richard, additional, Wolfla, Christopher, additional, Wong, Eric T., additional, Wormald, Peter J., additional, Wrensch, Margaret, additional, Wright, Neill M., additional, Wright, Zachary, additional, Yam, David, additional, Yamada, Shinya, additional, Yamada, Yoshiya, additional, Yang, Isaac, additional, Yang, Victor X.D., additional, Yao, Tom, additional, Yen, Chun-Po, additional, Yeoh, H. Kwang, additional, Yonekawa, Yasuhiro, additional, Yoo, Alice, additional, Yousem, David M., additional, Yuen, Eric C., additional, Zabramski, Joseph M., additional, Zacest, Andrew C., additional, Zacko, J. Christopher, additional, Zada, Gabriel, additional, Zafonte, Ross, additional, Zager, Eric L., additional, Zaidi, Hasan A., additional, Zarzour, Hekmat, additional, Zerris, Vasilios A., additional, Zivin, Justin A., additional, Zovickian, John G., additional, Zubkov, Alexander Y., additional, and Zwienenberg-Lee, Marike, additional
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- 2011
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30. Basic Principles of Cranial Surgery for Brain Tumors
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Weingart, Jon D., primary and Brem, Henry, additional
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- 2011
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31. Frame and Frameless Stereotactic Brain Biopsy
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Olivi, Alessandro, primary, Weingart, Jon D., additional, Liauw, Jason, additional, and Raza, Shaan M., additional
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- 2011
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32. TSC2 alterations in anaplastic ependymoma progression to ependymosarcoma
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Pujadas, Elisabet, primary, Chen, Liam, additional, Weingart, Jon D., additional, Orr, Brent, additional, Ozer, Bryam H., additional, Holdhoff, Matthias, additional, and Rodriguez, Fausto J., additional
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- 2020
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33. Abstract A32: Characterizing patterns of cytokine coexpression with immune checkpoint markers in CD4 and CD8 tumor-infiltrating lymphocytes
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Jackson, Christopher M., primary, Dinalankara, Wikum, additional, Choi, John, additional, Nirschl, Thomas R., additional, Kochel, Christina M., additional, Pant, Ayush, additional, Routkevitch, Denis, additional, Saleh, Laura, additional, Jackson, Christina, additional, Skaist, Alyza M., additional, Gupta, Anuj, additional, Snyder, Linda A., additional, Schaeffer, Edward M., additional, Ross, Ashley E., additional, Carter, Ballentine, additional, Allaf, Mohamad E., additional, Bivalacqua, Trinity J., additional, DeMarzo, Angelo M., additional, Weingart, Jon D., additional, Bettegowda, Chetan, additional, Brem, Henry, additional, Pardoll, Drew M., additional, Marchionni, Luigi, additional, Drake, Charles G., additional, and Lim, Michael, additional
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- 2020
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34. Treatment of recurrent glioblastoma multiforme with GliaSite brachytherapy
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Chan, Timothy A., Weingart, Jon D., Parisi, Michele, Hughes, Michael A., Olivi, Alessandro, Borzillary, Scott, Alahakone, Dineli, Detorie, Nicholas A., Wharam, Moody D., and Kleinberg, Lawrence
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- 2005
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35. Outcome Analysis of Childhood Low-Grade Astrocytomas
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Fisher, Paul G., Tihan, Tarik, Goldthwaite, Patricia T., Wharam, Moody D., Carson, Benjamin S., Weingart, Jon D., Repka, Michael X., Cohen, Kenneth J., and Burger, Peter C.
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- 2008
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36. Carmustine Implants: Potential in the Treatment of Brain Tumours
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Weingart, Jon D. and Brem, Henry
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- 1996
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37. Identification of der(1;19)(q10;p10) in Five Oligodendrogliomas Suggests Mechanism of Concurrent 1p and 19q Loss
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Griffin, Constance A., Burger, Peter, Morsberger, Laura, Yonescu, Raluca, Swierczynski, Sharon, Weingart, Jon D., and Murphy, Kathleen M.
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- 2006
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38. A clinicopathologic reappraisal of brain stem tumor classification: identification of pilocytic astrocytoma and fibrillary astrocytoma as distinct entities
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Fisher, Paul G., Breiter, Steven N., Carson, Benjamin S., Wharam, Moody D., Williams, Jeffery A., Weingart, Jon D., Foer, Dana R., Goldthwaite, Patricia T., Tihan, Tarik, and Burger, Peter C.
- Subjects
Brain tumors -- Research ,Tumors -- Identification and classification ,Health - Published
- 2000
39. Surgical Resection for Primary Central Nervous System Lymphoma: A Systematic Review
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Labak, Collin M., primary, Holdhoff, Matthias, additional, Bettegowda, Chetan, additional, Gallia, Gary L., additional, Lim, Michael, additional, Weingart, Jon D., additional, and Mukherjee, Debraj, additional
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- 2019
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40. Identifying Recurrent Malignant Glioma after Treatment Using Amide Proton Transfer-Weighted MR Imaging: A Validation Study with Image-Guided Stereotactic Biopsy
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Jiang, Shanshan, primary, Eberhart, Charles G., additional, Lim, Michael, additional, Heo, Hye-Young, additional, Zhang, Yi, additional, Blair, Lindsay, additional, Wen, Zhibo, additional, Holdhoff, Matthias, additional, Lin, Doris, additional, Huang, Peng, additional, Qin, Huamin, additional, Quinones-Hinojosa, Alfredo, additional, Weingart, Jon D., additional, Barker, Peter B., additional, Pomper, Martin G., additional, Laterra, John, additional, van Zijl, Peter C.M., additional, Blakeley, Jaishri O., additional, and Zhou, Jinyuan, additional
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- 2019
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41. 128 - Frame and Frameless Stereotactic Brain Biopsy
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Olivi, Alessandro, Weingart, Jon D., Liauw, Jason, and Raza, Shaan M.
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- 2017
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42. 129 - Basic Principles of Cranial Surgery for Brain Tumors
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Weingart, Jon D. and Brem, Henry
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- 2017
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43. Modifications to the Transverse Caspar Cervical Retractor Blades Optimized for a Single-Level Anterior Cervical Discectomy
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Geisler, Fred H., Tamargo, Rafael J., and Weingart, Jon D.
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- 1993
44. LAPAROSCOPIC SURGERY IN PATIENTS WITH VENTRICULOPERITONEAL SHUNTS: SAFETY AND MONITORING
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JACKMAN, STEPHEN V., WEINGART, JON D., KINSMAN, STEPHEN L., and DOCIMO, STEVEN G.
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- 2000
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45. Establishment and Biological Characterization of a Panel of Glioblastoma Multiforme (GBM) and GBM Variant Oncosphere Cell Lines
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Binder, Zev A., primary, Wilson, Kelli M., additional, Salmasi, Vafi, additional, Orr, Brent A., additional, Eberhart, Charles G., additional, Siu, I-Mei, additional, Lim, Michael, additional, Weingart, Jon D., additional, Quinones-Hinojosa, Alfredo, additional, Bettegowda, Chetan, additional, Kassam, Amin B., additional, Olivi, Alessandro, additional, Brem, Henry, additional, Riggins, Gregory J., additional, and Gallia, Gary L., additional
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- 2016
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46. Improvement of syrinx resolution after tonsillar cautery in pediatric patients with Chiari Type I malformation
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Stanko, Kevin M., primary, Lee, Young M., additional, Rios, Jennifer, additional, Wu, Adela, additional, Sobrinho, Giovanna W., additional, Weingart, Jon D., additional, Jackson, Eric M., additional, Ahn, Edward S., additional, Chaichana, Kaisorn L., additional, and Jallo, George I., additional
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- 2016
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47. Risk of surgical site infection in 401 consecutive patients with glioblastoma with and without carmustine wafer implantation
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Chaichana, Kaisorn L., primary, Kone, Lyonell, additional, Bettegowda, Chetan, additional, Weingart, Jon D., additional, Olivi, Alessandro, additional, Lim, Michael, additional, Quinones-Hinojosa, Alfredo, additional, Gallia, Gary L., additional, and Brem, Henry, additional
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- 2015
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48. Detection of circulating tumor DNA in early- and late-stage human malignancies
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Bettegowda, Chetan, Sausen, Mark, Leary, Rebecca J, Kinde, Isaac, Wang, Yuxuan, Agrawal, Nishant, Bartlett, Bjarne R, Wang, Hao, Luber, Brandon, Alani, Rhoda M, Antonarakis, Emmanuel S, Azad, Nilofer S, Bardelli, Alberto, Brem, Henry, Cameron, John L, Lee, Clarence C, Fecher, Leslie A, Gallia, Gary L, Gibbs, Peter, Le, Dung, Giuntoli, Robert L, Goggins, Michael, Hogarty, Michael D, Holdhoff, Matthias, Hong, Seung-Mo, Jiao, Yuchen, Juhl, Hartmut H, Kim, Jenny J, Siravegna, Giulia, Laheru, Daniel A, Lauricella, Calogero, Lim, Michael, Lipson, Evan J, Marie, Suely Kazue Nagahashi, Netto, George J, Oliner, Kelly S, Olivi, Alessandro, Olsson, Louise, Riggins, Gregory J, Sartore-Bianchi, Andrea, Schmidt, Kerstin, Shih, le-Ming, Oba-Shinjo, Sueli Mieko, Siena, Salvatore, Theodorescu, Dan, Tie, Jeanne, Harkins, Timothy T, Veronese, Silvio, Wang, Tian-Li, Weingart, Jon D, Wolfgang, Christopher L, Wood, Laura D, Xing, Dongmei, Hruban, Ralph H, Wu, Jian, Allen, Peter J, Schmidt, C Max, Choti, Michael A, Velculescu, Victor E, Kinzler, Kenneth W, Vogelstein, Bert, Papadopoulos, Nickolas, Diaz, Luis A, Bettegowda, Chetan, Sausen, Mark, Leary, Rebecca J, Kinde, Isaac, Wang, Yuxuan, Agrawal, Nishant, Bartlett, Bjarne R, Wang, Hao, Luber, Brandon, Alani, Rhoda M, Antonarakis, Emmanuel S, Azad, Nilofer S, Bardelli, Alberto, Brem, Henry, Cameron, John L, Lee, Clarence C, Fecher, Leslie A, Gallia, Gary L, Gibbs, Peter, Le, Dung, Giuntoli, Robert L, Goggins, Michael, Hogarty, Michael D, Holdhoff, Matthias, Hong, Seung-Mo, Jiao, Yuchen, Juhl, Hartmut H, Kim, Jenny J, Siravegna, Giulia, Laheru, Daniel A, Lauricella, Calogero, Lim, Michael, Lipson, Evan J, Marie, Suely Kazue Nagahashi, Netto, George J, Oliner, Kelly S, Olivi, Alessandro, Olsson, Louise, Riggins, Gregory J, Sartore-Bianchi, Andrea, Schmidt, Kerstin, Shih, le-Ming, Oba-Shinjo, Sueli Mieko, Siena, Salvatore, Theodorescu, Dan, Tie, Jeanne, Harkins, Timothy T, Veronese, Silvio, Wang, Tian-Li, Weingart, Jon D, Wolfgang, Christopher L, Wood, Laura D, Xing, Dongmei, Hruban, Ralph H, Wu, Jian, Allen, Peter J, Schmidt, C Max, Choti, Michael A, Velculescu, Victor E, Kinzler, Kenneth W, Vogelstein, Bert, Papadopoulos, Nickolas, and Diaz, Luis A
- Abstract
The development of noninvasive methods to detect and monitor tumors continues to be a major challenge in oncology. We used digital polymerase chain reaction-based technologies to evaluate the ability of circulating tumor DNA (ctDNA) to detect tumors in 640 patients with various cancer types. We found that ctDNA was detectable in >75% of patients with advanced pancreatic, ovarian, colorectal, bladder, gastroesophageal, breast, melanoma, hepatocellular, and head and neck cancers, but in less than 50% of primary brain, renal, prostate, or thyroid cancers. In patients with localized tumors, ctDNA was detected in 73, 57, 48, and 50% of patients with colorectal cancer, gastroesophageal cancer, pancreatic cancer, and breast adenocarcinoma, respectively. ctDNA was often present in patients without detectable circulating tumor cells, suggesting that these two biomarkers are distinct entities. In a separate panel of 206 patients with metastatic colorectal cancers, we showed that the sensitivity of ctDNA for detection of clinically relevant KRAS gene mutations was 87.2% and its specificity was 99.2%. Finally, we assessed whether ctDNA could provide clues into the mechanisms underlying resistance to epidermal growth factor receptor blockade in 24 patients who objectively responded to therapy but subsequently relapsed. Twenty-three (96%) of these patients developed one or more mutations in genes involved in the mitogen-activated protein kinase pathway. Together, these data suggest that ctDNA is a broadly applicable, sensitive, and specific biomarker that can be used for a variety of clinical and research purposes in patients with multiple different types of cancer.
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- 2014
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49. Contributors
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Aarabi, Bizhan, Abbott, Rick, Abd-El-Barr, Muhammad M., Abel, Taylor J., Abruzzo, Todd A., Acar, Feridun, Achey, Rebecca L., Ackerman, Paul D., Adams, Hadie, Adappa, Nithin D., Adelson, P. David, Aguirre-Padilla, David H., Ahmed, Raheel, Ahn, Edward S., Ailon, Tamir T., Ain, Michael C., Aisiku, Imoigele P., Alaraj, Ali, AlBakry, Amr, Albuquerque, Felipe C., Alexander, Brian M., Alexander, Michael J., Alexandrov, Andrei V., Ali, Zarina S., Al-Khalili, Kenan, Al-Mefty, Ossama, Almefty, Kaith K., Almefty, Rami, Alterman, Ron L., Amenta, Peter S., Ames, Christopher P., Amin-Hanjani, Sepideh, Ammirati, Mario, Andaluz, Norberto, Anderson, Richard C.E., Andrade, Pablo, Angevine, Peter D., Ansari, Shaheryar F., Ares, William J., Arle, Jeffrey E., Armonda, Rocco A., Arnaout, Omar, Arnaud, Eric, Arnold, Paul M., Assina, Rachid, Aszmann, Oskar C., Attenello, Frank J., III, Badhiwala, Jetan H., Baehring, Joachim M., Baggott, Christopher D., Bagić, Anto, Bahgat, Diaa, Bailes, Julian E., Bain, Mark, Ball, Perry A., Baltuch, Gordon H., Baraban, Scott C., Barak, Tanyeri, Barani, Igor J., Barbagallo, Giuseppe M.V., Barbaro, Nicholas M., Barker, Frederick G., II, Barnett, Gene H., Barone, Constance M., Barrow, Daniel Louis, Bassani, Luigi, Batchelor, Tracy T., Batista, Nuno, Batjer, H. Hunt, Baum, Griffin R., Beattie, Michael S., Beaumont, Andrew, Becker, Danielle A., Beckman, Joshua M., Becske, Tibor, Bederson, Joshua B., Beisse, Rudolf W., Bekelis, Kimon, Bell, Randy S., Belzberg, Allan J., Benarroch, Eduardo E., Bendok, Bernard R., Benet, Arnau, Berenstein, Alejandro, Berger, Mitchel S., Bergsneider, Marvin, Bertalanffy, Helmut, Bhatnagar, Saurabha, Bi, Wenya Linda, Birk, Harjus Singh, Bishop, Allen T., Blakeley, Jaishri O., Blomstedt, Patric, Bolinger, Bryan D., Bonney, Phillip A., Boomsaad, Zackary E., Boop, Frederick A., Borg, Nicholas, Boszczyk, Bronek M., Botelho, Ricardo Vieira, Bou-Haidar, Pascal, Bowyer, Susan M., Bragg, Taryn McFadden, Brem, Henry, Brem, Steven, Bresnahan, Jacqueline C., Brinkmann, Benjamin H., Brînzeu, Andrei, Britz, Gavin W., Brockmeyer, Douglas L., Browd, Samuel R., Brown, Desmond A., Brown, Martin, Brown, Matthew T., Brown, Robert D., Jr., Bruce, Jeffrey N., Brunstrom-Hernandez, Janice E., Brunswick, Andrew, Buell, Thomas J., Bullock, M. 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Alan, Holland, Eric, Holland, Ryan, Hongo, Kazuhiro, Horisawa, Shiro, Horner, Philip J., Houseman, Clifford M., Howard, Matthew A., III, Hsueh, Brian, Huang, Judy, Huang, Michael C., Huang, Raymond Y., Hudgins, Eric, Hunt, Matthew A., Hurlbert, R. John, Hutchinson, Peter J., Huttner, Anita, Hwang, Steven W., Iliff, Jeffrey J., Ingram, Susan L., Isaias, Ioannis U., Iskandar, Bermans J., Iyer, Aditya K., Jacob, R. Patrick, Jada, Ajit, Jadhav, Ashutosh P., Jaffer, Hayder, Jakacki, Regina I., Jallo, George I., Jallo, Jack I., Jamil, Osama, Jane, John A., Jr., Jane, John A., Sr., Janigro, Damir, Jankowitz, Brian T., Jea, Andrew H., Jeelani, Owase, Jehi, Lara, Jellinger, Kurt A., Jho, Diana, Jimenez, David F., Jo, Jasmin T., Johanson, Conrad E., Johnson, Luke A., Jones, Adrian C., Jones, Kristen E., Joseph, Jacob R., Jovin, Tudor G., Kalani, M. Yashar S., Kalanithi, Paul S.A., Kalfas, Iain H., Kalnins, Aleksandrs Uldis, Kalra, Ricky Raj Singh, Kamath, Ashwin A., Kang, Daniel G., Kang, James D., Kanter, Adam S., Kaplitt, Michael G., Karimi, Reza J., Kasliwal, Manish K., Kawasaki, Hiroto, Kelleher, John Paul, Kellner, Christopher P., Kemeny, Andras A., Kennedy, Benjamin C., Kestle, John R.W., Khan, Imad Saeed, Khan, Nadia, Khurana, Vini G., Kim, Dong Gyu, Kim, Dong H., Kim, Irene, Kim, Jin Wook, Kim, Louis J., Kim, Paul K., Kim, Thomas Aquinas, Kirsch, Wolff, Kitchen, Neil D., Klaas, James P., Klein, Joshua P., Kliot, Michel, Knightly, John J., Knopman, Jared, Ko, Andrew L., Koerner, John D., Kokoszka, Malgosia A., Kolias, Angelos G., Korja, Miikka, Kosztowski, Thomas, Krauss, Joachim K., Krishna, Chandan, Krishna, Vibhor, Krishnaney, Ajit A., Kubben, Pieter L., Kuhn, Jens, Kulkarni, Abhaya V., Kumar, Gomatam R. Vijay, Kuntz, Charles, IV, Kuo, Jeffrey V., Kwan, Kenny, La Marca, Frank, Laack, Nadia N. 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Loch, Mack, Stephen C., MacLachlan, Lara S., Macyszyn, Luke, Magarik, Jordan A., Maggio, Dominic, Magistretti, Pierre J., Mahaney, Kelly B., Maher, Cormac O., Mahmoodi, Ramin, Mahmoudi, Babak, Malessy, Martijn J.A., Mallucci, Conor, Mangano, Francesco T., Maniker, Allen H., Manley, Geoffrey T., Manolidis, Spiros, Marchac, Daniel, Marchione, Joseph, Marcus, Joshua, Maroon, Joseph C., Martin, Alastair, Martin, Neil A., Mascitelli, Justin R., Mathur, Amit, Maulucci, Christopher M., Mazur, Marcus D., Mazwi, Nicole, McAllister, James P., II, McClain, Craig D., McCutcheon, Ian E., McDougall, Cameron G., McEvoy, Andrew W., McGoldrick, Patricia E., McGovern, Robert A., III, McKhann, Guy M., II, Meaney, David F., Medel, Ricky, Mehta, Minesh P., Melega, William P., Menezes, Arnold H., Mertens, Patrick, Meyer, Fredric B., Meyer, R. 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Andrew, Winer, Jesse L., Winfree, Christopher J., Winkler, Ethan A., Winn, H. Richard, Wisoff, Jeffrey H., Witsch, Jens, Wolf, Steven M., Wolfla, Christopher E., Wolinsky, Jean-Paul, Wong, Cyrus C., Wong, Eric T., Wrensch, Margaret R., Wu, Jau-Ching, Xu, Linda Wei, Xu, Zhiyuan, Yan, Carol H., Yap, Edward, Yarbrough, Chester K., Yasuno, Katsuhito, Yavin, Daniel, Yener, Ulaş, Yonekawa, Yasuhiro, Young, Timothy P., Youngblood, Mark W., Youngerman, Brett E., Yu, Jennifer S., Yue, John K., Yuh, Esther L., Zabramski, Joseph M., Zacest, Andrew C., Zacko, J. Christopher, Zada, Gabriel, Zadicario, Eyal, Zadnik, Patricia Leigh, Zafonte, Ross D., Zager, Eric L., Zanotti, Bruno, Zellner, Elizabeth G., Zhan, Shikun, Zhang, Chencheng, Zhang, Xiaoxiao, Zhang, Y. Jonathan, Zisakis, Athanasios K., Zuckerman, Scott L., Zumofen, Daniel W., and Zwienenberg-Lee, Marike
- Published
- 2017
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50. Rapid malignant transformation of low-grade astrocytomas: report of 2 cases and review of the literature
- Author
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Frazier, James L., Johnson, Michael W., Burger, Peter C., Weingart, Jon D., and Quinones-Hinojosa, Alfredo
- Published
- 2010
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